Abstract: It is in the scope of the invention to disclose a biocidic textiles and fabrics, comprising at least one insoluble proton sink or source (PSS). The textiles and fabrics is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact; the PSS comprising (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential; wherein the PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

Abstract: The invention relates to an antimicrobial composition comprising a mixture of at least 20 wt. % lactic acid or a derivative thereof and an inorganic acid selected from a nitrogen, sulfur, and phosphorous acid, and mixtures thereof for use in animal nutrition. In one of the embodiments the composition further comprises at least one other acid selected from acetic acid, fumaric acid, gluconic acid, (iso)butyric acid, sorbic acid, (iso)valeric acid, maleic acid, malic acid, capronic acid, benzoic acid, and citric acid. In a special embodiment the composition comprises lactic acid or polylactide, which is attached to a support.

Abstract: The invention features an antimicrobial composition comprising a substance P peptide and methods of inhibiting growth of a microorganism by contacting the microorganism with a substance P peptide. Bacterial and fungal pathogens are inhibited by the substance P compositions.

Abstract: The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein is employed in an immunogenic composition, such as a vaccine. Methods to induce an immune reaction in an individual with compositions of the invention are provided.

Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,

Abstract: The present invention concerns a method of agaricidal and microbicidal treatment of textile materials, a Neem oil microcapsule composition specifically for said treatment and a bioactive textile material obtained. More particularly, the present invention concerns the industrial and commercial areas of the treatment of fabrics and like products and is of particular application to textile materials produced from natural fibers such as cotton, feathers or down, or synthetic fibers such as polyester, nylon, acrylic or the like, or mixed fibers such as polyester-cotton. The present invention concerns a method of agaricidal and microbicidal treatment of a textile material, in which microcapsules containing Neem oil are fixed on said textile material.

Abstract: The invention relates to a pre-packaged, pre-moistened towel, which is customized. The towel is made from a woven cloth material, which can be customized by printing logos, designs or words on the towel. The towel can be either disposable or reusable.

Abstract: A method of treating a substrate having a charge bias with at least one antimicrobial agent to modify the release properties of the antimicrobial agent with respect to the substrate, the method includes eliminating, mitigating, or modifying the charge bias of the substrate by applying at least one first agent to the substrate, and applying the at least one antimicrobial agent to the substrate. Related articles are also described.

Abstract: A composition and method for the prevention and therapeutic treatment of skin conditions and disorders are disclosed. The composition and method of the invention are particularly directed to the treatment and prevention of dermal irritations. These irritations include, for example, psoriasis, eczema, ichthyosis, pruritus, dryness and dermatitis, which may cause skin to crack, chap or chafe. The composition and method are particularly useful in treating and preventing diaper dermatitis. A therapeutic composition according to the invention includes an agent, which is an enzyme constituent, promoting the synthesis of collagen and the reproduction of cells, particularly skin cells. Such therapeutic agents include, for example, zinc oxide. This agent is generally nonprescription and capable of effectively preventing and treating diaper dermatitis through local or topical application.

Abstract: According to the present invention, an isolated and purified DNA sequence which encodes a lantibiotic, mutacin I, is disclosed. The nucleic acid sequence is set forth in SEQ ID No: 1 and the amino acid sequence is set forth in SEQ ID No: 2.

Abstract: Antibiotics used to cure Uterine Tract Infections have resulted in the growth of MRSA. and other antibiotic resistant bacteria. The CDC guidelines state “Disposable diapers cause 95% of all UTI'S”. The procedures used for “prevention” are ineffective because millions of bacteria in incontinence garments continue to double every 20 minutes. Silver ions in bandages are used to cure severly damaged skin, such as in burns. The best two in a large scale test achieved results in just 30 minutes. This Invention uses silver ions in linings next to the skin to stop the growth of over 250 kinds of infectious bacteria on it's surface and the body parts it touches. It achieves results in 30 minutes, equal to the most highly rated bandages . . . for every level of incontinence for both sexes.

Abstract: The present invention provides novel broad spectrum antiseptic compounds that further have properties that allow them to be coated/impregnated into polymer surfaces. Methods for coating these antiseptic compounds onto medical devices especially indwelling medical devices to prevent the growth of pathogens in such devices and hence, to prevent infection to patients via such devices are provided. The invention also provides antiseptics that are useful as general surface disinfectants and sterilizers, fluid disinfectants and biocide preservatives.

Abstract: A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

Abstract: The present invention also provides a method for making the antimicrobial plant fibers. The characteristic of the method is no need of additional reducing agent. The present invention provides plant fibers with antimicrobial effects. The antimicrobial antifungal effect of the fibers is derived from nanosilver particles (diameter between 1 and 100 nm) which are attached to the fibers. The fibers which are made of cotton, linen, blending fibers, or any combination thereof. The fibers can be used to make yarn cloth to be used particularly for treating patients with burns or wound. The cloth made from the antimicrobial fibers can be further used to make clothes such as underwears, socks, shoe cushions, shoe linings, bed sheets, pillow cases, towels, women hygiene products, laboratory coats, and medical robes.

Abstract: The present invention provides a topical composition for application to the perianal and/or labial areas of the skin which helps prevent viscoelastic fluids, such as menses and feces, from attaching to the skin and aids in the reducing the viscoelastic properties of the fluid so that the fluid can flow into absorbent articles. The composition contains at least one viscoelastant material and at least one an anti-adherent material. the composition may be applied with a wipe, including mitts and gloves, a solid stick composition, an aerosol dispenser, a pump spray, a trigger spray, a squeeze bottle, as a foam, as a cream, as an ointment, as a salve, as a gel, as a wash or as a lotion. In addition, absorbent articles, such as pads or pants, diapers and the like may also be used as a means to transfer the composition to the skin.

Abstract: A breast support system, bra and related apparel are disclosed that comprise a support member having an outer surface and an inner surface, wherein the support member comprises at least one antibacterial material, at least one anti-absorbent material, at least one antimicrobial material or a combination thereof.

Abstract: The invention relates to antimicrobial polyester-containing articles utilizing chitosan and chitosan-metal complexes, whose wash durability is improved by covalently bonding the chitosan species to the polyester. The invention also relates to the methods of preparing said articles.

Abstract: The present invention relates to micro-sized particles having anti-biocontaminant properties. Each particle is comprised of a central metal core, or support structure, (for example, alumina oxide) and has on its surface, one or more anti-biocontaminant metals and at least one redox agent.

Abstract: A method for inhibiting growth of a Staphylococcus aureus, Propionibacterium, and Escherichia coli comprises the steps of providing an anti-microbial agent comprising Sasa tannin and contacting the microorganism to the anti-microbial agent.

Abstract: The fabric consists of lycra fibres and microfibres and it has long the fibres a glycoprotein (9) and an exapeptide (10). The woof of this fabric and the active principles given to these two substances (9, 10) prevent and/or give the first cures to the diabetic foot.

Abstract: A garment or footwear based on a synthetic thermoplastic polymer material containing (a) an antibacterial agent selected from phenolic antimicrobial compounds of the formula (I) wherein n is 0 or preferably 1, R1 and R2 are hydrogen or chloro, R3 is hydroxyl or preferably hydrogen, R4, R5 and R6 are hydrogen or chloro, R7 is hydroxyl, and X is a direct bond, —NHCONH—, —CH2— or preferably —O—; and (b) an antifungal agent selected from benzimidazole fungicides, triazoles, 2,4-bis(alkylamino)pyrimidines, isothiazolinon fungicides, 10,10?-oxy-bis-phenoxyarsen, zinc pyrithione has good antimicrobial properties.

Abstract: Abrasive compositions which include bioactive materials, such as bioactive glass and bioactive ceramics, which provide biological properties such as anti-inflammatory, anti-microbial, anti-oxidant effects, improved wound healing, and/or other beneficial effects are provided. Also provided are abrasive compositions comprising relatively non-toxic, bioinert glasses and ceramics which provide good abrasive effects, reduce or eliminate potentially harmful small particles; reduce or eliminate clogging of dermabrasion equipment; possess a relatively large surface area for applying coatings; and may be inexpensive and simple to make. Methods for abrading human or animal tissue, such as human skin, by contacting such tissue with these abrasive compositions is also provided.

Abstract: A disinfectant delivery system and method of providing alcohol-free disinfection to a body to be disinfected, as well as a method of infection reduction by preparation of a patient before an invasive procedure. A blended cloth comprising first fibers and second fibers is provided with the first fibers generally being greater in quantity by weight than the second fibers. A disinfectant solution impregnates the blended cloth, with the disinfectant solution having chlorhexidine gluconate as an active ingredient and having no alcohol. In the method according to the invention, at least one impregnated blended cloth is used to disinfect at least a portion of a body. A plurality of blended cloths can be provided for disinfecting discrete portions of the body.

Abstract: Topically applicable dermatological/cosmetic compositions suited for ungual/peri-ungual administration for the treatment of a variety of pathologies, including fungal pathologies, such as onychomycosis, contain (a) at least one biologically active agent (e.g., antifungal) and (b) at least two of the pro-penetrating agents selected from the group consisting of urea, an organic acid and an ethoxydiglycol, the at least two-pro-penetrating agents respectively being present in effective amounts as to synergistically improve the ungual/peri-ungual bioavailability of the at least one biologically active agent.

Abstract: The invention relates to antifungal compositions and methods for protecting a plant from a fungal pathogen. Compositions including antifungal polypeptides isolated from a fungal fermentation broth are provided.

Abstract: An antibacterial formulation which comprises: (a) at least one water soluble copper compound able to form copper ions upon dissolution in an aqueous medium; (b) at least one water soluble ammonium agent able to form ammonium ions upon dissolution in an aqueous medium; (c) at least one water soluble acid, and (d) an aqueous medium within which components (a), (b) and (c) are dissolved, said formulation having (e) an acidic pH and (f) an electrolytic potential in excess of 50 millivolts.

Abstract: The present invention is directed to attaching drugs and other functional groups to surfaces of nano-sized diamonds (NDs) to enhance the efficacy of drugs and other substances. The method involved enhancing the efficacy of a drug having an active site by acquiring a plurality of nanodiamond (ND) particles having a plurality of carbon chain surface molecules on its surface. Intermediate amine entities are covalently attached to the surface molecules of the ND particles. These are then replaces with said drug molecules such that the active sites of said drug molecules point away from the ND particle exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs are enhanced, however, this may be used with many different types of drugs.

Abstract: The present disclosure relates to an article having a fiber including an antimicrobial agent to inhibit growth of microorganisms. The article inhibits the growths of microorganisms in biological, physiological fluids, and non-biological solutions. The article includes a fibrous structure and silver halide particles applied to the fibers to inhibit the growth of the microorganism.

Abstract: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the fungus Magnaporthe grisea with respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

Abstract: Compositions including an isolated Bacillus species, spores or an extracellular product of B. coagulans, suitable for topical application, for inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus are disclosed. Methods of inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus by topical application of compositions that include an isolated Bacillus species, spores or an extracellular product of a B. coagulans strain are disclosed.

Abstract: Methods of treating acne include the use of formulations including a benzoyl peroxide solution and an antioxidant.

Abstract: Benzoyl peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions. Treatment of truncal acne vulgaris with a combination of actives, namely benzoyl peroxide and salicylic acid, is provided via regimens that include applying such benzoyl peroxide compositions to an area of the body afflicted with acne, after a waiting period rinsing the benzoyl peroxide-treated area (e.g., by showering), drying the rinsed area, and then applying a topical, at least partially neutralized salicylic acid composition to the afflicted area.

Abstract: The subject matter relates to a topical, foamable composition including at least one antifungal agent, said composition characterised in that said at least one antifungal agent is able to penetrate the upper layers of skin and is retained in or on an area to be treated for a prolonged period of time, and in that it has a residual non-volatile component content of less than 25%. The subject matter furthermore relates to a method of treating fungal diseases including jock itch, tinea, dandruff and sebborheic dermatitis by applying to the affected area of a patient requiring such treatment the antifungal composition.

Abstract: A wipe that includes a bacteriostatic agent that contains cations having an affinity for the negatively charged cell walls of bacteria is provided. The affinity of the bacteriostatic agent for the bacteria allows the wipe to capture bacteria, thereby removing them from a surface and also inhibiting their spread to other surfaces that may contact the wipe. Of particular advantage, the bacteriostatic agent may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics. Still further, the wipe of the present invention also contains a solvatochromatic indicator that undergoes a color change in the presence of a broad spectrum of bacteria. Thus, when the wipe captures bacteria, the indicator undergoes a color change that signals to the user that the wipe is functioning properly. The lack of a color change may likewise provide the user with the assurance that the area is generally free of bacteria and clean.

Abstract: The present invention discloses compositions derived from an isolated Bacillus species spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.

Abstract: The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.

Abstract: Microbial growth on the surface of a valve of a voice prosthesis and optionally the cartridge or ring supporting the valve, is inhibited by providing antimicrobial activity at a level sufficient to retard growth of a microbial film by dispersing an inorganic antimicrobial agent such as silver oxide or an organic antimicrobial agent such as triclosan or butyl paraben dispersed in a medical grade silicone elastomer. The valve, ring or cartridge is in contact with body fluids containing microorganisms and nutrients therefor. The antimicrobial surface can interfere with or inhibit the growth of a biofilm, bacterial layer or a yeast layer. The body of the prosthesis may also contain an antimicrobial surface as long as it is non-toxic to the tissue it contacts.

Abstract: A process for decontaminating water, comprising contacting the water with iodine, contacting the solution with a nylon polymer selected from the group consisting of nylon-6, nylon-4,6 and nylon-6,6, and then separating the so-formed iodophor from the solution.

Abstract: The invention discloses an innovative process to produce highly antibacterial nano-composite fabric textile containing silver metal compound. The process mainly uses high-energy D-ray radiation to modify silver type of bactericides and graft or crosslink them onto Nylon or PET fiber surface to produce excellent antibacterial textile products. The mechanism uses silver nano-compound as performance additive and through Co-60 irradiation technique reduces and firmly fastens silver particles onto Nylon or PET (Polyethylene Terephthalate) fiber material. Because the inorganic silver type bactericides actively interact with enzymes in bacteria or destroy cell walls to achieve good bactericidal effect, the radiation process does not need initiators or other additives. So the process is simple and effective. The test results prove excellent bactericidal power and potential value in household or medical textile products.

Abstract: Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.

Abstract: The neck-tie according to the present invention is made with an antibacterial yarn. This yarn presents intrinsic antibacterial properties and performs both a bacteriostatic and a bactericidal function. Said yarn is obtained by means of a procedure that entails adding, before the spinning phase, an antibacterial agent that comprises a dispersion of silver atoms or ions directly to the material that will go to form the yarn.

Abstract: An extruded component formed from an extruded material having antimicrobial components is disclosed. The extruded material may be formed from polymers and formed into a generally elongated shape. The antibacterial components may extend from an outer surface of the extruded material radially outward. A color dye coating may be placed on the outer surface of the extruded material. The antibacterial component may be sized such that the color dye coating may be applied to the outer surface of the extruded material without compromising the effectiveness of the antibacterial component.

Abstract: A wearing article includes an article element and a fastening mechanism. The article element includes at least one pack unit that has a fabric housing and a flexible pad body fitted into the fabric housing and including a thin elastic matrix of an elastic material and a plurality of functional particles dispersed in the matrix and capable of providing at least one of the functions consisting of emitting far-infrared rays, emitting negative ions, and destroying bacteria. The fastening mechanism is secured to the pack unit so as to permit wearing of the pack unit by the human body and abutment of the fabric housing against the human body.

Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from maize. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the embodiments are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant a DNA construct comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the embodiments. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the embodiments in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.

Abstract: A method of inactivating viruses is provided. The method comprises the step of topically applying an antimicrobial composition comprising: an organic acid; and an anionic surfactant mixture having a characteristic selected from the group consisting of: a linear alkyl chain having a chain length of from about C4 to about C12 and a total head group size of at least about 4 Angstroms; a branched alkyl chain having a chain length of from about C4 to about C12; an unsaturated alkyl chain having a chain length of from about C4 to about C12; and combinations thereof to an area in need of treatment.

Abstract: An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0 percent by weight of fluconazole and 1.0-40.0 percent by weight of any one compound selected from a group consisting of fatty acid, fatty alcohol, higher fatty acid ester and lower alcohol based on weight of the base material. The composition according to the present invention has various advantages of a favorable absorption into a system through the skin of a human body and delivery of active material into horny layer of the skin, a reduced skin stimulation and an excellent stability. Therefore, the composition is efficiently useable in a medical treatment application for dermatomycosis-related infectious diseases including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and/or candidiasis and the like.

Abstract: Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.

Abstract: The present invention discloses a pharmaceutical method comprising urea, a hydrophilic film-forming agent, water and/or a water-alcohol mixture that is suitable for the removal of abnormal keratinous material.

Abstract: The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.

Abstract: Composition and method for simultaneously disinfecting and conditioning a wooden cutting surface, such as a cutting board or counter top. According to a preferred embodiment, the composition comprises a mixture of ethanol and food-grade mineral oil where the ethanol is present in an amount sufficient impart antiseptic properties. To the extent desired, other adjuvants, such as flavor enhancers, coloring agents, and the like may be added. The method comprises contacting the wooden cutting surface with such composition for a time sufficient to enable the ethanol to adequately disinfect the cutting surface. Preferably, such method may be performed by merely spraying or wiping the composition directly onto the wooden cutting surface.