Abstract: Provided herein are compositions and formulations comprising an antifungal agent. Pharmaceutical compositions comprising luliconazole in an amount effective for the treatment of onychomycosis are provided. Also provided are methods for treating dermatomycoses and onychomycosis using the compositions and formulations.

Abstract: Tissues useful in providing fibrous tissue products for skin contact, such as facial tissue, bathroom tissue, disposable handkerchiefs which comprise a volatile rhinological effective composition for delivery to human skin.

Abstract: A method for treating periodontal disease, which comprises administering an effective amount of a composition to one in need of treatment of periodontal disease, the composition comprising a Sasa extract and an organic acid.

Abstract: The present invention relates to protecting a human from an infection using a disinfecting agent as described herein and a method for use thereof, more particularly to a rare earth-containing device for protecting a wound and a method for use thereof.

Abstract: The wound treatment therapy deactivates pathogenic microorganisms within the wound environment without disrupting the cell walls. The wound treatment therapy of this invention combines the application of stabilized hypochlorous acid compound with the application of a hydrophobic wound dressing. The application of hypochlorous acid provides the initial anti-microbial agent, which disrupts and eradicates biofilm, as well as, deactivates the harmful pathogenic organisms within the wound environment. The application of the hydrophobic wound dressing, which is designed to bind harmful hydrophobic microorganisms and toxins, provides a mechanical vehicle for physically removing deactivated hydrophobic microorganisms form the wound environment with each dressing change.

Abstract: The present invention relates to antifungal materials, particularly to nanoparticles comprising or consisting of a non-persistent inorganic support material such as Tricalciumphosphate (TCP) and copper as a dopant in the form of Cu+/?0, Cu+1 and or Cu+2; to composite materials or liquid formulations containing such nanoparticles. Further, the invention relates to the manufacture of such nanoparticles, composites, liquid formulations and to the use of such nanoparticles, composites, liquid formulations as an antifungal component.

Abstract: An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.

Abstract: The invention relates to a wound dressing having a backing and an antimicrobial wound contact layer, wherein the wound contact layer has a hydrophobized active ingredient.

Abstract: The invention is directed to an antimicrobial metal composite formed by vaporizing an antimicrobial metal or antimicrobial metal salt such as silver, copper or salts thereof using an plasma system and cooling the formed vapor in the presence of a fluidized gas of filler powder. Alternatively, the filler or a filler precursor is entrained with the antimicrobial metal or antimicrobial metal precursor and vaporized and then upon cooling the antimicrobial metal vapor and filler vapor condense to form the composite. The composite shows high antimicrobial activity and can be incorporated into or onto polymers, coatings, textiles, paper, gels (for example for wound care), lubricants, adhesives and cosmetics or pharmaceutical, especially medical devices.

Abstract: The present invention refers to a treatment for mixed infectious diseases in the human reproductive system, wherein an association of compounds containing fluconazole and either tinidazole or secnidazole is used, the same being associated in doses lower to those commonly used therapeutically. The combination has proven to be highly efficacious and shown a good degree of tolerance.

Abstract: A synergistic system for substantially reducing surface contaminants of a food and inhibiting yeast, mold and bacteria growth in a food, beverage or food grade cosmetic preparation comprising a substantially transparent and odorless solution made from a plurality of substantially organic compounds selected from: citric acid, sodium citrate, vegetable glycerin, sea salt, potassium sorbate, decyl glucoside, calcium ascorbate, grapefruit seed extract, quillaja saponin, calcium carbonate, ascorbic acid, sodium percarbonate and sodium bisulfite, and an applicator for applying the solution to the food substance.

Abstract: It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.

Abstract: Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.

Abstract: In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A topical skin barrier for protecting and promoting healing of skin, and for providing comfort to a patient, comprises a semi-solid hydrocarbon and a water-absorbing compound. The topical skin barrier effectively adheres to skin, affords protection from moisture and waste, and provides transparency in use. Methods of in vitro evaluation are for (i) a composition's protection from moisture and waste, and (ii) a composition's adhesion to skin.

Abstract: A moisture-permeable glove or other garment protects against user contamination and cross-contamination by providing both rapid and persistent sterilization. Exposure to halogen of inherent NH groups and/or attached hydantoin can form a persistent outer halamine sterilization layer. A second inner halamine layer intercepts any pathogens that penetrate the outer surface. The garment can be single layer, or can include a detachable inner liner. Embodiments are compatible with rapid decontamination using an alcohol-based agent. Some embodiments provide a 180 second 3-log kill rate for at least S. aureus ATCC and E. coli. Embodiments include a moistening agent to activate the halamine. An anti-cut/puncture layer and/or a pathogen barrier layer can also be included. The protective layer can include contiguous layers of soft and hard metal flexed to improve flexibility and Moisture Vapor Transport Rate (MVTR). The pathogen barrier can include urethane and/or CNT fibers. The garment MVTR can be greater than 0.

Abstract: An antimicrobial wipe that contains a polymer coating having a synergistic combination of ingredients for providing controlled release of an antimicrobial agent and also good antimicrobial efficacy is provided. One such ingredient is a high molecular weight polyamideamine release agent. Due to the polycationic nature of the release agent, it is able to adhere to the wipe, which is generally formed from fibers having a negative surface charge (e.g., cellulosic fibers). In this manner, the release agent can occupy binding sites on the wipe to inhibit the antimicrobial agent from adhering thereto, thus allowing it to be expressed in the germicidal solution to kill microbes on the desired surface. The adherence of the release agent to the wipe is even further enhanced by crosslinking the polyamideamine to increase its molecular weight, thereby enabling it to form a structural network that physically adheres to the wipe and that blocks the antimicrobial agent from binding thereto.

Abstract: The present invention provides anhydrous compositions for topical delivery of a medicament comprising (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol, or any combination of any of the foregoing; and (C) an anhydrous vehicle. In an alternate embodiment, the present invention provides anhydrous compositions for topical delivery of a medicament which comprise (A) a penetration enhancer/solvent selected from the group consisting of alcohol, propylene glycol, or a combination thereof; (B) a humectant/solvent selected from the group consisting of polyethylene glycol, glycerin, sorbitol, xylitol or any combination of any of the foregoing; (C) an anhydrous vehicle; and (D) a medicament.

Abstract: Gelatinous foam, coated paper, fabric, and polymer materials combined with the Colloidal Silver or Gold additive to formulate products with antimicrobial surfaces. Some embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface and in any shape. The various embodiments include coated polymer sheets, polymer trays, bamboo and/or cotton towels and fabric, polymer foam, or polymer mats containing nano-silver or nano-gold in an scheduled and organized manner (with input/requests from the customer) to create permanent or semi-permanent anti-microbial surfaces.

Abstract: The present invention is directed to an antimicrobial composition, comprising pyrithione or a pyrithione complex; and a zinc or copper or silver source selected from the group consisting of zinc or copper or silver salts, oxides, hydroxides, sulfates, chlorides, metals, and combinations thereof; wherein the weight ratio of the zinc or copper or silver source to the pyrithione or the pyrithione complex is in the range from about 1:300 to about 50:1, and wherein the antimicrobial composition has an enhanced biocidal effect against a variety of free-living microorganisms or biofilms. Also disclosed is a method of inhibiting the growth of free-living microorganisms or biofilm utilizing the above antimicrobial composition, as well as use of such antimicrobial compositions in various products including fuels, fluids, lubricants, coatings, adhesives, sealants, elastomers, soaps, cosmetics, plastic or woven or non-woven fibers, pharmaceuticals, and as preservatives for the above products.

Abstract: A kit for promoting hair growth on areas of the scalp that has been affected by fungal infections. The kit reduces the loss of hair, gradually destroys the cause of the loss of hair, and eventually restores the normal hair growth in the areas of the scalp affected by the fungi. The kit is comprised of a first powdered mixture and three liquid compositions. The elements of the kit are applied to the scalp of an individual experiencing hair loss due to fungi.

Abstract: Disclosed is a composition comprising betamethasone, griseofulvin and tea tree oil, for use in the treatment of ear fungal infections, particularly otomycosis, particularly infections caused by Aspergillus niger or Candida albicans. The composition may be in the form of ointment, cream, gel or liquid, e.g. ear drops.

Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.

Abstract: Provided herein are compositions and formulations comprising an antifungal agent. Pharmaceutical compositions comprising luliconazole in an amount effective for the treatment of onychomycosis are provided. Also provided are methods for treating dermatomycoses and onychomycosis using the compositions and formulations.

Abstract: Provided herein are compositions and formulations comprising an antifungal agent. Pharmaceutical compositions comprising luliconazole in an amount effective for the treatment of onychomycosis are provided. Also provided are methods for treating dermatomycoses and onychomycosis using the compositions and formulations.

Abstract: Provided herein are biocidic compositions including an ion exchange material, wherein when said material is in an environment capable of transporting H+, said ion exchange material is adapted to cause the death of at least one cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the ion exchange material. Also provided herein are methods of making the foregoing biocidic compositions. In addition, provided herein are methods of using the foregoing biocidic compositions to cause the death of at least one cell.

Abstract: This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous compounds, thereby removing these compounds from a medium such as air or water. Metal ions are adsorbed onto the surface of the nanoparticle and bound strongly to the surface. By selection of the metal ion, specific gaseous compounds and/or odorous compounds can be targeted and removed efficiently and effectively from both aqueous phase and from the air. The modified nanoparticles are useful in numerous article of manufacture for industrial and consumer use.

Abstract: The present invention relates to the field of non-woven textile products, and is applied to the manufacture of non-woven fabric products or generally nonwovens for various applications such as household use and personal care. In particular, the present invention relates to a wet nonwoven fabric product impregnated with a substance for personal care, household application or topic medical use, characterised in that the said nonwoven fabric is a bonded web structure with hydrophilic properties or that is made hydrophilic by treatment with wetting additives.

Abstract: The present disclosure encompasses compositions comprising a surfactant, and an acid such as, but not limited to, levulinic acid, that together have a synergistic effect in reducing the viability of a virus population compared to the efficacy of the individual compounds. This synergy allows the formulation of compositions where the active agents (including an acid and a surfactant) are present at concentrations effective to inactivate viruses on surfaces, including human skin. The viricidal compositions disclosed herein are efficacious without damaging the surface to which they may be applied, or even altering the organoleptic properties of a treated food substance. The viricidal compositions and wipes containing such compositions are suitable for sanitizing any surface suspected of having a viral load thereon, or where it is desirable to ensure that a viral load is as low as possible.

Abstract: The use is described of zinc pyrithione for finishing woven and non-woven textiles to render them resistant against colonization by house dust mites. Zinc pyrithione is used alone or in combination with other actives with or without other textile chemicals. The formulations comprising zinc pyrithione are applied to the textiles using the standard processes of textile finishing, such that there is a concentration of preferably 1000 to 6000 ppm of zinc pyrithione on the textile. This gives on uncoated sheetlike textiles a very distinct reduction in the mite population in testing; ideal finishes even eliminate the mite population completely.

Abstract: Materials and methods, for preparation of coatings based on titanium dioxide for osteointegrated biomedical prostheses. The coatings may comprise nanomaterials having antibacterial properties. For example, an endo-osseous implant is provided with a coating comprised of nanocrystalline material comprising nanoparticles of formula (I) (L-Men+)i,??(I) where AOx represents TiO2 or ZrO2; Men+ is a metallic ion having antibacterial activity, with n=1 or 2; L is a bi functional organic molecule which can simultaneously bind to the metal oxide and to the metallic ion Men+, and i is the number of L-Men+ groups bound to one nanoparticle of AOx.

Abstract: Urea compositions useful for treatment of dermatological conditions. The compositions, which are free from perceptible solids, may include at least about 50 wt-% urea, zinc pyrithione, and lactic acid, and may be formulated as a topical gel.

Abstract: The present invention relates to nanomaterials comprised of metal oxides associated with cationic metals having antibacterial activity. In particular, the present invention relates to nanocrystalline compounds of formula (I): AOx-(L-Men+) i, (I) where AOx represents the metal oxide or metalloid oxide, with x=1 or 2; Me11“1” is a metal ion having antibacterial activity, with n=1 or 2; L is a bifunctional molecule, either organic or organometallic, capable of binding simultaneously with the metal oxide or metalloid oxide and the metal ion Men+; and i represents the number of L-Men+groups bound to a AOx nanoparticle.

Abstract: Disclosed is a method for killing spores from a surface or a material, comprising applying an effective amount of a biocidal composition which comprises one or more biguanide polymers, and one or more further active agents on said surface or material, characterised in that the or each further active agent is, when taken alone, sporicidally inactive. Compositions comprising polymeric biguanides and one or more further biocidal agents and, optionally, a polyorganosiloxane, have been found to be effective as a sporicidal agent and are particularly effective against the spores of C. difficile. The compositions may be used in industry, in domestic applications and are particularly suitable for use in hospital due to their low toxicity. Furthermore, the method may comprise impregnating a fabric to thereby provide long lasting sporicidal activity thereto.

Abstract: A long-lasting persistent, uniform film-forming skin protecting germicidal composition provides a long-lasting persistent barrier film when applied to skin. The compositions have particular utility as barrier teat dips for protecting cows against mastitis. A barrier film-forming agent is selected from the modified or hydrolyzed polysaccharides, particularly a hydrolyzed or modified starch, such as dextrin and maltodextrin. The barrier film-forming agent is stably solubilized in a solvent that dries to form the long-lasting persistent uniform film over the animal skin. The compositions also contain antimicrobial agents that fight against microbes that manage to penetrate the protective barrier film. Particularly, advantageous is that all the materials used are safe food additive and cost effective over the traditional barrier film forming agents.

Abstract: The present application defines an antimicrobial composition comprising (a) at least two antimicrobial agents having different antimicrobial mechanisms of action and being present in amounts that together provide a synergistic antimicrobial effect or (b) an antimicrobial agent and a surface modifying agent, an antimicrobial masterbatch comprising antimicrobial composition (a) or (b) and a polymer carrier, an antimicrobial fibre composition comprising the antimicrobial masterbatch and a fibre substrate, an antimicrobial fibre comprising a fibre body or a fibre surface having the antimicrobial fibre composition, and a process for producing antimicrobial fibres.

Abstract: A sheet for pest control, wherein said sheet is of polymeric material and comprises at least two layers; a top layer and a bottom layer, wherein the bottom layer contains a herbicide and one or more pesticides selected from among fungicides and insecticides, and the top layer optionally containing an insecticide and/or fungicide. Other aspects of the invention include a polymeric composition used in the preparation of the sheets and a method for pest control in agriculture, horticulture and gardens.

Abstract: Textiles coated with aqueous compositions of silane quaternary ammonium compounds and alkali metal bicarbonates are provided with deodorization properties and protection from allergens, irritants, molds, dust mites, bacteria, and fungi.

Abstract: Disposable absorbent articles comprising an absorbent material and an antimicrobial composition are disclosed. The antimicrobial composition includes a carrier comprising fatty alcohol and a poly(alkyleneoxy) polymer, and an antimicrobial agent. The antimicrobial composition may be coated on to component substrates such as nonwovens and films, that are incorporated into disposable absorbent articles, such as disposable infant diapers, adult incontinence articles, feminine hygiene articles such as sanitary napkins, wound dressings, bandages, panty liners and tampons, personal care wipes and household wipes to provide odor control, and control of microbial growth.

Abstract: A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).

Abstract: A composition for treating fabric includes about 0.1 to about 10.0% cross linking agent, about 0.1 to about 5.0% of a material selected from a group consisting of oxidized polyolefin, polyolefin and mixtures thereof, about 0.1 to about 0.5% wetting agent, about 1.0 to about 14.0% of a material selected from a group consisting of aminofunctional silicone, ionizing agent and mixtures thereof, about 0.0 to about 2.0% catalyst, about 1.0 to about 3.0% antimicrobial/antibacterial/antifungal agent and any remainder as a carrier. The composition has a pH of between about 2.0 to about 4.0. A performance fabric treated with the composition and a method of treating a performance fabric are also provided.

Abstract: Provided are articles containing a solid surface material with an antimicrobial agent in a thermoset and/or thermoplastic resin matrix, wherein the antimicrobial agent comprises a chitosan-metal complex.

Abstract: The present invention is an auxiliary washing aid comprising a textile substrate coated or otherwise impregnated with a composition comprising elementary silver and/or a silver compound, non-neutralized fatty acid, and hydrogen peroxide.

Abstract: The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.

Abstract: A proteineous component isolated from plant chromatin, after dissociation of the same, as an antimicrobial agent, the proteineous component having an apparent molecular weight between 10 and 20 kD. The proteineous plant component is produced by means of a method comprising the steps of homogenizing a plant material in order to expose its plant chromatin, dissociating the plant chromatin with a dissociating agent under hydrophobic conditions, and separating the dissociated plant chromatin into individual fractions, one comprising the proteineous plant component, by means of a hydrophobic interaction separation procedure.

Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.

Abstract: An absorbent article has a skincare composition applied on at least a portion thereof so as to be transferable to the skin of the wearer. The composition is solid at 21° C. and includes at least three constituents, being chosen according to their melting behavior, and characterized, in particular, by the presence of a crystallization accelerator.

Abstract: A pharmaceutical composition comprising at least 0.1 ?mol of formaurindicarboxylic acid or its derivatives in 1 kg of pharmaceutically acceptable carrier. The pharmaceutical composition of claim 1 wherein the composition is in the form of solution prepared using aqueous alcali or water.

Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.

Abstract: Highly active, leach-resistant, antimicrobial nonwoven textiles are prepared by treating at least one surface of the nonwoven material with an anionic polyelectrolyte, such as carboxymethyl cellulose, alginic acid, poly(acrylic acid) etc and at least one select quaternary ammonium antimicrobial agent. The textiles of the invention, and products produced from them, exhibit a highly effective quick kill rate, for example a log 4 CFU reduction within a 5 minute contact time, against microbes such as fungi and gram (?) and gram (+) bacteria.