Abstract: The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.

Abstract: A method for applying a barrier to structures to prevent the infiltration of pest species (unwanted organisms) uses a (e.g., coating) composition formed from a polyurethane (e.g., film-forming) polymer system and a pellet comprising a pesticide incorporated into a sorbent and dispersed in the polyurethane polymer system. The composition protects the structure by application either to the structure or to a pathway that leads to the structure. Advantageous polymer systems include polyurethanes rich in urea linkages and predominating in aliphatic and alicyclic backbones.

Abstract: A composition including a bait and a borate is used to mitigate a population of target insects and/or mollusca. The composition may include attractive by-products of agriculture and manufacturing with or without semiochemicals or biopesticides prepared as point source units (such as pellets or microcapsules). The by-products attract insects and/or mollusca to a food source for the purpose of mitigating the target organism. The bait is combined with borates and is pelletized and/or encapsulated into micron size particles. The pelletized and/or encapsulated particles are broadcast (spread) over areas infested with the target insect. The insects ingest the composition and regurgitate the composition to the remainder of the insect population. Significant mitigation of the population of the target insects results with little to no effect on the environment. The composition is also passed on to the next generation due to cannibalism of the target insects.

Abstract: There is provided a topical composition that comprises (a) a substantially anhydrous insect repellent selected from the group consisting of ethyl 3-(N-butylacetylamino) propionate or a derivative thereof, p-menthane-3,8-diol, hydroxyethyl isobutyl piperidine carboxylate (1-piperidine carboxylic acid), and mixtures thereof, and (b) a non-volatile solvent. A second embodiment of the present composition includes the same insect repellent, and a volatile solvent, and, optionally, a film former. A third embodiment includes the same insect repellent, a non-volatile solvent, a volatile solvent, and, optionally, a film former.

Abstract: The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

Abstract: This invention refers to new surface-active compounds derived from arginine of the mono and diacylglyceride type according to the general formula (I) designed to act as surface agents with antimicrobial activity. The variations in the activity will depend on the number of fatty chains and their length. The purification of the intermediate and final products is achieved by means of liquid/liquid, liquid/solid extractions, crystallizations, ion-exchange chromatography and reverse-phase HPLC.

Abstract: A solid pesticidal formulation, such as wettable powders, water dispersible granules and water soluble formulations, enveloped in a water soluble substance, such as polyvinyl alcohol and so on, wherein the solid pesticidal formulation comprises at least one water soluble hydroxy compound selected from the group consisting of alkanols, alkylene glycols, glycol monoethers, tri- or more valent alcohols, alcoholamines, hydroxyfatty acids and hydroxyfatty acid esters, or water soluble glycol ether acetates is excellent in stability after preserved.

Abstract: An insect repellent substrate (10) includes a fabric base material (12) made of felt which is impregnated with a repellent carrier composition (14). The carrier composition (14) includes a mixture of wax and a naturally occurring insect repellent such as pyrethrum oil. The carrier composition (14) may also include scented or aromatic oils such as citronella oil, rosemary oil, eucalyptus oil and neem oil. Strips of the fabric base material may be attached to headwear such as a headband or cap so that it is in contact with the wearer's hair or body. Active constituents of the carrier composition (14) provide effective treatment and prevention of headlice and other parasitic insects.

Abstract: Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with antigen.

Abstract: A novel method of encapsulating an active substance in a biodegradable polymer, which comprises: a) dissolving said biodegradable polymer in an organic solvent therefor; b1) dispersing said active substance in the organic solution obtained in step a) to provide a dispersion with the active substance as the inner phase thereof; or alternatively b2) emulsifying said active substance, dissolved in water or other aqueous solvent therefor, in the organic solution obtained in step a) to provide an emulsion with the active substance as the inner aqueous phase thereof; and c) subjecting the dispersion obtained in step b1), or alternatively the emulsion obtained in step b2), to an encapsulation operation with an aqueous polyethylene glycol solution as a continuous phase to provide micro- or nanoparticles having the active substance encapsulated therein. Sustained release particles obtainable thereby.

Abstract: A method of preventing damage to the shoots and foliage of a plant by a pest includes treating the seed from which the plant grows with a composition that includes at one pyrethrin or synthetic pyrethroid. In another embodiment, the pesticide is not limited to pyrethrins or synthetic pyrethroids when the seed is a transgenic seed having at least one heterologous gene encoding for the expression of a protein having pesticidal activity against a first pest and the pesticide has activity against at least one second pest. Treated seeds are also provided.

Abstract: Disclosed herein is an aqueous suspension of insecticidally active compounds comprising a solid active compound applied as a coating to an inorganic carrier and auxiliaries, water and glycerol.

Abstract: A planting method for preventing pests, especially snails, is disclosed. The method includes the steps of (a) providing a biodegradable material, (b) adding a pesticide into the biodegradable material, and (c) spreading the pesticide-added biodegradable material on a plant-growing substrate. Therefore, a plant growing on the plant-growing substrate will not undergo the damage of pests.

Abstract: Microbiological control in aqueous media and/or eradication or reduction of biofilm on a surface in contact with such media is achieved by introducing into the aqueous medium a microbiocidally effective quantity of one or more 1,3-dibromo-5,5-dialkylhydantoins where one of the alkyls is methyl and the other is a C1-4 alkyl, wherein (i) the molar quantity of 1,3-dibromo-5,5-dialkylhydantoin introduced is less than the molar quantity of N,N′-bromochloro-5,5-dimethylhydantoin that would be required to effect the same degree of microbiological control in that medium, (ii) the molar quantity of the 1,3-dibromo-5,5-dialkylhydantoin introduced releases an amount of “free chlorine” that is greater than the amount of “free chlorine” that would be released in that medium by an equimolar quantity of N,N′-bromochloro-5,5-dimethylhydantoin, and (iii) the amount of “free chlorine” released by the quantity of the 1,3-dibromo-5,5-dialkylhydantoin introduced is greater than the

Abstract: Microbiological control is achieved by continuously and inexpensively dosing water in contact with biofilm, or that comes into contact with biofilm, using a highly effective biocide that provides very effective microbiocidal control of planktonic microorganisms and of biofilm species, even where the biofilm infestations have been in existence for long periods of time and thus have encased themselves in a substantial quantity of slimy defensive polysaccharide layers or films. In addition, the biocide used makes possible significant reduction in copper and/or iron surfaces in contact with the water as compared to N,N′-bromochloro-5,5-dimethyl hydantoin. Still other advantages are made possible by the described technology.

Abstract: Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or associated with lipid carriers, particularly cationic lipid carriers. Multiple individual tisssues can be transfected using naked DNA. Using a DNA: lipid carrier complex. multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.

Abstract: This invention relates to a water dispersible granule comprising; (1) a pesticidally active ingredient (2) a copolymer of maleic anhydride and diisobutylene or a salt thereof (3) a compound selected from the group consisting of a polyoxyethylene alkyl phenyl ether Sulfuric acid ester, a polyoxyethylene aryl phenyl ether sulfuric acid ester, a polyoxyethylene alkyl phenyl other phosphoric acid ester, and a polyoxyethylene aryl phenyl ether phosphoric acid ester, or a salt thereof (4) a water soluble carrier selected from the group consisting of water soluble polymers, succharides, and reduction products thereof sulfates, carbonates, phosphates, condensed phosphoric acids and salts thereof, solid organic acids, solid organic acid salts, protein, amino acids and a urea, and (5) a water swellable material, The present composition is excellent in disintegration in water and storage stability, and after the storage for a long time, it keeps excellent property as water dispersible granules such as disintegrati

Abstract: Microbiological control in water systems is achieved with an amount,of 1,3-dibromo-5,5-dimethylhydantoin that is less than the amount of N,N′-bromochloro-5,5-dimethylhydantoin required to achieve the same degree of microbiological control. The methods of combating Escherichia coli and/or Enterococcus faecium in an aqueous medium, and biofilms such as formed by Pseudomonas aeruginosa on surfaces contacted by the aqueous medium, involve introducing into the medium a biocidally effective amount of 1,3-dibromo-5,5-dimethylhydantoin. A microbiological control agent for use in water in accordance with U.S. Environmental Protection Agency regulations is purveyed in containers of a water control agent comprising 1,3-dibromo-5,5-dimethylhydantoin, which containers bear a label having thereon dosage levels pursuant to requirements promulgated by the U.S. Environmental Protection Agency. The 1,3-dibromo-5,5-dimethylhydantoin is used or purveyed either as a product having a large average particle size (e.g.

Abstract: The present invention may include a cleanser having a liposome and greater than about 40 weight percent of a solvent. The liposome may be loaded with the solvent more than about 7 days after the manufacture of the liposome. The solvent may be an isoprenoid or ester solvent. Furthermore, the solvent may be d-limonene or a dibasic ester. In addition, the liposome may be selected from the group consisting of large unilamellar vesicles, multilamellar vesicles, paucilamellar vesicles, and small unilamellar vesicles. Desirably, the liposome is a paucilamellar vesicle. Desirably, the cleanser may have a solvent weight percent greater than about 60. More desirably, the cleanser may have a weight percent of solvent greater than about 80. Moreover, the solvent is about a 1:1 weight ratio of d-limonene and dibasic ester.

Abstract: The present invention features a sustained-release microcapsule for long-term pest controlling. In general, a microcapsule has a capsule core including active pest-control ingredients and diluents, and a capsule shell which physically separates the capsule core from the surrounding medium. Diluents are arranged to entrap active ingredients therein and to provide resistance to mass transfer of the active ingredients therethrough. The capsule shell generally includes the shell pores and provides additional resistance to mass transfer of the active ingredient therethrough. Diluents are selected from a class of material such that the mass transfer resistances existing in the capsule core and/or capsule shell depend on the temperature of the surrounding medium.

Abstract: An anti-fungal treatment, for use on skin, comprising an anti-fungal component and a skin treating component. The skin treating component either absorbs moisture on the skin to make an undesirable environment for the fungus, or treats the skin to allow the anti-fungal component to penetrate, allow the skin to heal, and to create an unpleasant, oily environment for the fungus. The anti-fungal component is a combination of goldenseal root powder with ipe roxo powder and poke root powder. The skin treating component is either a skin softening mixture, such as D-alpha tocopherol and olive oil, or is a dehydrator, such as arrowroot and ball clay. A further combined anti-fungal and aromatic component preferably comprises lavender oil, and may also comprise teatree oil.

Abstract: A plurality of releasably loaded elastomeric microspheres comprising a plurality of elastomeric microspheres loaded with at least one releasable agriculturally active agent within the optical boundaries of the elastomeric microspheres and post-polymerization addition and in-situ polymerization processes for preparing the releasably loaded elastomeric microspheres are also provided.

Abstract: The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method for controlling agricultural pests by applying to the pest or the locus of the pest a pesticide composition comprising a pesticide and a redispersible polymer.

Abstract: Cosmetic skin care compositions containing a high performing retinyl ester which is an ester of retinol with C18, unsaturated, non-essential, cis-6 and/or cis-12 fatty acid. The ester is preferably selected from the group consisting of gamma-retinyl linolenate, retinyl petroselinate, and retinyl cis-12-octadecenoate.

Abstract: This invention relates to certain natural diatomaceous earth granule compositions which can be broadcast, i.e., dry spread on the soil to deliver a pesticide or fertilizer. The granules retain their physical integrity when spread, and have the unique property to spontaneously disintegrate when irrigation water is applied or rainfall hits the particle. Upon wetting, the particle disintegrates (blooms) to cover the soil surface. This bloom can cover an area many times the original area covered by the granule. The granules have high loadings of the diatomaceous earth, i.e. from about 35 to about 95 weight percent and contain from about 5 to about 40 weight percent of a surfactant system which exhibits excellent disintegration; rewetting and binding properties. Bioactive compounds can be loaded at up to 60 weight percent of the granule. Bioactive compounds may be formulated products or technical grades and may be homogeneously distributed throughout the granule or spray impregnated onto the granule.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of ore or more aquatic organisms in a column of water. The complexes comprise a least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: A composition containing a plurality of multicellular vesicles and at least one nucleic acid, at least one part of which is found included inside the multilamellar vesicles. Each of the vesicles is formed of a succession of lamellar bi-layers extending from each vesicle center to its periphery and including at least one surfactant agent. The bi-layers are concentric and are separated by a liquid medium. Such compositions can be used in pharmaceutics, particularly gene therapy, and in in vitro and in vivo transfection.

Abstract: The present invention features an adjuvanted vaccine, and methods for preparing an adjuvanted vaccine, preferably for immunizing against influenza, where the adjuvant is a lipid vesicle, and preferably is a nonphospholipid, paucilamellar lipid vesicle. The antigen may be encapsulated in the central cavity of the adjuvant, or mixed in solution with the adjuvant. Moreover, the adjuvant may carry a secondary adjuvant to further improve the immune response.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: Solid water-dispersible compositions containing microencapsulated pesticides are produced by spray-drying an aqueous suspension of said pesticides in the presence of a water-soluble polymer, preferably polyvinyl alcohol.

Abstract: Poly(ADP-ribose) polymerase (“PARP”) inhibitors and methods for treating neurodegenerative diseases, neural tissue damage related to cerebral ischemia and reperfusion injury, and cardiovascular in an animal.

Abstract: The present invention provides a slow release pesticide formulation which comprises at least one of pesticidal components, a hydrophobic substance in an ester family which has a melting point not lower than 60° C. but lower than the melting point of the pesticidal component and has an acid value from 10 to 50 mg KOH/g, and inorganic dilution carrier.

Abstract: A skin sanitizing composition includes an effective amount of an alcohol having 1 to 4 carbon atoms for providing sanitizing activity to the sanitizing composition as well as an effective amount of at least one moisturizing agent having opacifying properties for both making the sanitizing composition uniformly opaque when mixed and reducing water loss from the skin. The composition also includes an effective amount of a polymeric thickener for providing a viscosity of from about 1000 to about 65,000 cps and water.

Abstract: The present invention describes a composition which includes a binder, a pigment, an insect toxicant, an insect feeding stimulant or a toxicant regeneration enhancer, and an ingredient which is both a filler and a thickener. The composition may be applied to a solid substrate to reproduce an article of manufacture which is both attractive and toxic to insect pests and therefore useful for insect control.

Abstract: A topical insect repellent with extended duration of protection was obtained from mixtures of molecules based on two or more volatile repellent organic molecular species occurring naturally on the human skin surface. The novel repellent comprises mixtures of lower, intermediate, and higher volatility organic molecules. Active ingredients for formulations are obtained from homologous series of carboxylic acids, alcohols, ketones, and lactones which span a similar range of volatility and which occur naturally on the skin surface. Volatile silicone fluid imparts mildness and water repellency to the repellent formulations. The new natural repellent exhibits the longevity and repellency that is comparable to N,N-diethyl-m-toluamide (DEET), a synthetic compound employed in almost all commercial formulations, but the inventive natural repellent is more acceptable than DEET, which has an unpleasant odor and imparts a greasy feel to the skin.

Abstract: Flexible articles especially hydrophilic sponges featuring long-lasting residual antimicrobial benefits, contain a carrier mass having dispersed within an effective amount of an biocidal composition such as a preservative. Process for the production of such flexible hydrophilic articles are also disclosed.

Abstract: Tubules which contain an active agent in their lumen and compositions containing such microtubules are effective for providing a slow, controlled release of the active agent. Such microtubules are useful in the production of coating compositions for the protection of surfaces coming into contact with water, adhesive resins for the production of laminated wood products, and devices for dispensing pesticides.

Abstract: A method is described for controlling or exterminating moles through the use of a bait composition in the form of a gel, paste, or grease. The composition includes an attractant and an active ingredient capable of killing vertebrate pests. The composition is injected into a mole tunnel through a small diameter nozzle, tube or needle to avoid digging open the tunnel or causing it to collapse.

Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.

Abstract: The cosmetic composition includes hydrophobic lipophilic materials as the principle vehicle carrying the active ingredients in a continuous solid phase, the composition is formed into a hairstick by locating the composition in a container having means to mechanically extrude the composition out of the open end of the container. A unique process is provided for forming the composition and locating the composition in the container. In one embodiment the composition is layered alternately between removably impermeable membranes in the container such that when the top layer of composition is used, the next lower membrane may be removed to allow the next layer of composition to be used.

Abstract: The invention relates to a rigid sand body consisting of a plurality of sand grains adhering to one another and provided with a coating consisting of wax, wherein the sand body is abradable, as well as to a process for its preparation, which is characterized in that sand grains and wax are heated separately from one another at a temperature of 50-90° C., the heated sand grains and the heated, liquid wax are added together and the composition obtained is allowed to cool for solidification. The sand bodies of the invention are particularly suitable as a sand scrub for skin massage or as a modelling or model component. The invention also relates to a process for producing discrete agglomerated sand grains provided with a coating having burls consisting of wax by abrading the sand body of the invention. The resulting abration sand comprising sand grains surrounded by wax are very well suited as sliding and slipping bases.

Abstract: A pesticidal or herbicidal composition in particulate form which comprises composite particles. Each of said particles contains a core of an inert substance having a pesticidal herbicide associated therewith and a coating of an electrically resistive material around the core. The particles may also include a second pesticidal material adhering to the electrically resistive coating. The particles carry an electrostatic charge.

Abstract: The present invention provides an improved conjunctival insert for topical delivery of medication or lubrication into the conjunctival spaces and upon the ocular surface of human eye. Specifically, three physical designs are provided, differing by size, named “Large”, “Medium” and “Small”. Also provided are methods of treating ocular maladies and of lubricating or moisturizing a dry eye using the disclosed conjunctival inserts. Such inserts can also be used for veterinary practices in the cases of primates and quadrupeds.

Abstract: An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms and improving allograft survival rates comprising the use of omega-9 unsaturated fatty acids to alter the immune response associated with organ transplantation. It is administered optionally in conjunction with an immunomodulatory diet comprising arginine and its salts, or metabolic precursors of arginine, together with an immuno-suppressive treatment comprising the administration of cyclosporine or other immuno-suppressants and optionally, with or without a donor specific transfusion. An especially preferred source of the omega-9 unsaturated fatty acids is canola oil.

Abstract: A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flue virus. The assemblies are typically in the form of liposomes which can be maintained in a suspension, and show great intensity in their color changes. Their method of production is also described.

Abstract: A plasmid-liposome composition for transfection of a cell is described. The composition includes plasmid molecules condensed with a polycationic condensing agent and cationic liposomes. Also disclosed is a method for preparing the plasmid-liposome complexes.

Abstract: Described herein is a method for making a flake for use in a topical application. The flake is formed by contacting a liquid phase waxy material that may contain pigments, fragrance, plasticizer, hydrophilic modifier with a pseudoplastic hydrophilic gel, and/or an active ingredient. The waxy material contacts the surface of the gel and after the two materials have contacted, the waxy material is solidified and forms a sheet. This sheet is then broken into pieces to form the flakes of the present invention. The flakes can be used in formulating any topical product that can contain a lipid material.

Abstract: Vaccines for the induction of immunity to malaria, based on aluminum hydroxide-treated, lipid A- and malarial antigen-containing liposomes, are described. Vaccines of this sort are useful in both humans and animals.

Abstract: The present invention relates to a bioactive feed pellet comprising besides commonly used nutritionally valuable components, a biologically active ingredient such as a therapeutically or prophylactically active compound, a vaccine, a pigment, a vitamin, and/or an enzyme, whereby the bioactive ingredient has been applied to the pellet in the form of a primary coating dispersion and/or emulsion and/or solution in a fatty component or a mixture of dietary oil, said component or dietary oil comprising a triglyceride, and/or fatty acid thereof, having a melting point of above 35.degree. C. in an amount of at least 0.05% by weight of the total weight of the pellet, and in an amount comprising at least 0.2% by weight of said coating, and that a further, second coating layer of an oily product has been applied after said coating dispersion, and/or emulsion and/or solution comprising the bioactive ingredient.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.