Waxes, Fatty Acids, Etc. (e.g., Liposome, Etc.) Patents (Class 424/420)
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Patent number: 6043098Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: January 22, 1998Date of Patent: March 28, 2000Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 6043099Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: January 22, 1998Date of Patent: March 28, 2000Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 6040197Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: January 22, 1998Date of Patent: March 21, 2000Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 6036964Abstract: Cosmetic compositions are disclosed which are made from a multi-component base made from at least three different components, which base exhibits a weight loss not exceeding 46% in a 24 hour period in a controlled environment with minimum air flow in a humidity chamber with a temperature of 35-40 degrees C. and 80% humidity; and a medium volatility fragrance, wherein a solubility parameter is calculated for each of the base and fragrance components are matched so that the difference between them is less than 38%.Type: GrantFiled: March 5, 1998Date of Patent: March 14, 2000Assignee: Colgate-Palmolive CompanyInventors: Eric P. Guenin, John C. Brahms, Anne Elisabeth Vickery Gale, Patricia Ann Hall-Puzio, Peter R. Hilliard, Gail Sharon Klewsaat, Cuthbert Donald Taylor, Paul Joseph Vincenti
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Patent number: 6033917Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: January 22, 1998Date of Patent: March 7, 2000Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 6034130Abstract: Synthetic lipid composition in which the content and the distribution of the fatty acids are similar to those of human milk fat, containing less than 2% by weight of free fatty acids, in which palmitic acid is predominantly at the 2-position of the triacylglycerols and the arachidonic and docosahexaenoic acids are distributed between the 1-, 2- and 3-positions and in particular predominantly at the 2-position of the triacylglycerols.Type: GrantFiled: July 13, 1998Date of Patent: March 7, 2000Assignee: Nestec S.A.Inventors: Junkuan Wang, Raymond Bertholet, Pierre Ducret, Mathilde Fleith
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Patent number: 6022874Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.Type: GrantFiled: December 23, 1998Date of Patent: February 8, 2000Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 6004572Abstract: A system to deliver a treating agent of interest to a surrounding environment over an extended period of time is described. The system comprises surrounding a treating agent or agents with one or more biodegradable materials. The biodegradable materials biodegrade at a rate that will slowly and continuously release the treating agent or agents of interest to the surrounding environment. An example of the method of the present invention is described for the treatment of wood supporting structures to prevent their decay and rotting in the earth. The method is particularly advantageous for treating wood supporting structures including, but not limited to: telephone poles, utility poles, pilings, railroad ties, posts, foundations and other building supports and the like.Type: GrantFiled: January 25, 1996Date of Patent: December 21, 1999Assignees: Triangle Laboratories, Inc., University of N.C. - Chapel HillInventors: Donald J. Harvan, Frederic K. Pfaender
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Patent number: 6001346Abstract: A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.Type: GrantFiled: September 9, 1996Date of Patent: December 14, 1999Assignee: The Regents of the University of CaliforniaInventors: Michael Delwiche, John M. Krochta, Richard E. Rice, Cynthia Atterholt
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Patent number: 5994151Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: January 22, 1998Date of Patent: November 30, 1999Assignee: Richard-James, Inc.Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 5994317Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.Type: GrantFiled: April 9, 1996Date of Patent: November 30, 1999Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 5929027Abstract: A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in admixture with a pharmaceutically acceptable carrier or diluent, which is suitable for oral administration and for application to the oral cavity, by which the polypeptide can sufficiently be absorbed through the intestinal tract or the mucous membrane in the oral cavity and exhibit the physiological activities without being suffered from enzymolysis.Type: GrantFiled: March 12, 1997Date of Patent: July 27, 1999Assignee: Teikoku Seiyaku Kabushiki KaishaInventors: Shigeyuki Takama, Yukiko Inamoto, Takahiko Wato, Akiya Yamada, Naoki Uchida, Misuzu Kadoriku
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Patent number: 5925370Abstract: A biorepellent matrix structure comprises a resin and first and second micapsules suspended in the resin. The first and second microcapsules each includes a first shell and a second shell, respectively, containing a biorepellent material that is released upon penetration of any of the first and second shells, as for example, by a biological organism. The biorepellent material, such as capsaicin, diffuses through the first and second shells at different rates. The different diffusion rates of the biorepellent material together provide a biorepellant matrix structure that exhibits long term protection against the formation of biological organisms that would otherwise accumulate on the matrix structure, and deters organisms from gnawing or chewing the matrix structure.Type: GrantFiled: December 4, 1997Date of Patent: July 20, 1999Assignee: The United States of America as represented by the Secretary of the NavyInventors: David M. Bullat, Niraj Vasishtha
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Patent number: 5922594Abstract: Methods are disclosed for producing a substrate surface supporting a continuous planar bilayer lipid membrane by covalently binding a plurality of micellar of vesicle liposomes, optionally comprising a membrane protein or other biologically active membrane-bound component, to a substrate surface supporting a self-assembled monolayer (SAM) of essentially straight long chain molecules. In one embodiment, the micellar or vesicle liposomes covantly bind to hydrophilic spacer molecules attached to the functional groups of the self-assembled monolayer.Type: GrantFiled: March 25, 1997Date of Patent: July 13, 1999Assignee: Biacore ABInventor: Stefan Lof.ang.s
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Patent number: 5908632Abstract: The invention relates to a process for encapsulating biologically active compounds in the form of substantially spherical microparticles, comprising the steps ofa) preparing an aqueous solution of surfactants, catalysts and monomers or prepolymers which are suitable for forming a crosslinked polycondensate,b) forming an emulsion of the substantially water-insoluble biologically active compound or mixture thereof in the solution a) by adding said solution under high shear force, andc) forming a solid capsule wall around the biologically active compound or mixture thereof by heating the reaction mixture to a temperature at which the crosslinking reaction tales place,which process comprises fusing the biologically active compound or mixture thereof and adding the melt to the aqueous reaction mixture at a temperature which is higher than the temperature of the reaction mixture.Type: GrantFiled: January 21, 1997Date of Patent: June 1, 1999Assignee: Novartis CorporationInventors: Rudolf Nastke, Ernst Neuenschwander
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Patent number: 5908707Abstract: Wet-like cleaning wipes and similar articles are described. These wipes comprise a carrier that provides controlled fluid absorbency and an emulsion applied to the carrier. The emulsion comprises a continuous external lipid phase and a polar (e.g., water) internal phase. The emulsion is sufficiently brittle that it ruptures when subjected to low shear pressures during use to release the dispersed polar phase. The carrier allows the released internal phase to initially reach and remain on the surface being cleaned, but then absorbs the material at the end of the wiping process.Type: GrantFiled: December 5, 1996Date of Patent: June 1, 1999Assignee: The Procter & Gamble CompanyInventors: David William Cabell, Larry Neil Mackey, Robert Stanley Ampulski, Paul Dennis Trokhan, John William Toussant, James Edwin Cartledge, Jr., Nicholas James Nissing
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Patent number: 5902596Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.Type: GrantFiled: September 29, 1997Date of Patent: May 11, 1999Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Patent number: 5888528Abstract: A powder for sustained release of a gas including a hydrophilic core, a hydrophobic layer on an outer surface of the hydrophilic core, and particles in contact with the hydrophobic layer. The hydrophobic layer contains an acid releasing agent. The particles contain an anhydrous material capable of binding with water. The core, the particles, and the hydrophobic layer are substantially free of water, and the core is capable of generating and releasing a gas after hydrolysis of the acid releasing agent.Type: GrantFiled: May 19, 1997Date of Patent: March 30, 1999Assignee: Bernard Technologies, Inc.Inventors: Stephen T. Wellinghoff, Sumner A. Barenberg, Hong Dixon, Joel J. Kampa
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Patent number: 5885598Abstract: Insecticidal compositions which have an active content of buprofezin (I) ##STR1## in combination with insect-pathogenic fungi.Type: GrantFiled: August 10, 1995Date of Patent: March 23, 1999Assignee: Hoechst Schering Agr Evo GmbHInventors: Werner Knauf, Esperanza Morales
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Patent number: 5885605Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled. release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials.Type: GrantFiled: September 2, 1997Date of Patent: March 23, 1999Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Patent number: 5876739Abstract: The present invention relates to an insecticidal coating for a seed comprising one or more binders selected from the group consisting of polymers and copolymers of polyvinyl acetate, methyl cellulose, polyvinyl alcohol, vinylidene chloride, acrylic, cellulose, polyvinylpyrrolidone and polysaccharide and an insecticide and filler wherein the binder forms a matrix for the insecticide and filler resulting in a substantially non-phytotoxic seed coating; methods for producing said coating and the seed treated with the above described coating.Additionally the invention concerns a method of controlling soil-borne insect pests, particularly from the order of Coleoptera, such as Diabrotica spp., comprising applying to a seed an insecticidal coating as described above.Type: GrantFiled: June 23, 1997Date of Patent: March 2, 1999Assignee: Novartis AGInventors: Kevin M. Turnblad, Yuguang Chen
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Patent number: 5861397Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.Type: GrantFiled: October 3, 1996Date of Patent: January 19, 1999Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 5858384Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.Type: GrantFiled: August 21, 1997Date of Patent: January 12, 1999Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Patent number: 5858386Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.Type: GrantFiled: September 2, 1997Date of Patent: January 12, 1999Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Use of dimethyl substituted oxymethyl cyclohexane derivatives for their insect repellency properties
Patent number: 5855903Abstract: Described is a method of repelling Musca domestica L.(Diptera:Muscidae), Aedes aegypti, Culex nigripalpus, Aedes atlanticus, Culex salinarius, Aedes vexans, Culex spp., Simulium spp., Psoroferia ferox, Aedes infirmatus, Drosophila melanogaster, Coccinellidae, Anopheles crucians, Psoroferia columbiae, Culicoides spp., Aedes spp. and Haematobia for a finite period of time from a three dimensional space inhabited by at least one of such insect species consisting essentially of the step of exposing a three dimensional space to an effective insect species member repelling concentration and quantity of a dimethyl substituted oxymethyl cyclohexane derivative-containing composition of matter defined according to the structure: ##STR1## The above-stated repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.Type: GrantFiled: November 20, 1997Date of Patent: January 5, 1999Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Craig B. Warren, Anna B. Marin, Jerry F. Butler, Anubhav P. S. Narula -
Patent number: 5855917Abstract: Methods of inhibiting lipoprotein lipase and controlling the body fat and the body weight of an animal employ an effective amount of at least one 20 carbon, conjugated, unsaturated, fatty acid. Pharmaceutical compositions for use in the method are also disclosed. The 20-carbon conjugated fatty acids are selected from an eicosadienoic acid, an eicosatrienoic acid, and an eicosatetraenoic acid. Preferably, the fatty acids are 11,13-eicosadienoic acid; 12,14-eicosadienoic acid; 8,11,13-eicosatrienoic acid; 5,8,11,13-eicosatetraenoic acid; 5,8,12,14-eicosatetraenoic acid, or an ester, salt, or mixture thereof.Type: GrantFiled: December 4, 1996Date of Patent: January 5, 1999Assignee: Wisconsin Alumni Research FoundationInventors: Mark E. Cook, Yeonhwa Park, Michael W. Pariza
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Patent number: 5851818Abstract: An improvement in a method of preparing plasmid-liposome complexes for in vivo transfection is described. The improvement includes selecting a condensing agent to condense the plasmid prior to contact with the liposomes, selecting a working medium and selecting a ratio of liposome lipid to plasmid. Also disclosed are DNA plasmid-liposome complexes formed by the method.Type: GrantFiled: March 28, 1997Date of Patent: December 22, 1998Assignee: Sequus Pharmaceuticals, Inc.Inventors: Shi Kun Huang, Edwin Kiyoshi Oto, Mohammad Hassanipour, Bei Jin
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Patent number: 5849320Abstract: The present invention relates to an insecticidal coating for a seed comprising one or more binders selected from the group consisting of polymers and copolymers of polyvinyl acetate, methyl cellulose, polyvinyl alcohol, vinylidene chloride, acrylic, cellulose, polyvinylpyrrolidone and polysaccharide and an insecticide wherein the binder forms a matrix for the insecticide; methods for producing said coating and the seed treated with the above described coating.Additionally the invention concerns a method of controlling soil-borne insect pests, particularly Diabrotica spp., comprising applying to a seed an insecticidal coating as described above.Type: GrantFiled: June 13, 1996Date of Patent: December 15, 1998Assignee: Novartis CorporationInventors: Kevin M. Turnblad, Yugu Ang Chen
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Patent number: 5840325Abstract: Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.Type: GrantFiled: February 26, 1996Date of Patent: November 24, 1998Assignee: Stryker CorporationInventors: Thangavel Kuberasampath, David C. Rueger
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Patent number: 5827703Abstract: Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or complexed to lipid carriers, particularly cationic lipid carriers. Multiple individual tissues can be transfected using naked DNA. Using a DNA: lipid carrier complex, multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.Type: GrantFiled: May 19, 1994Date of Patent: October 27, 1998Assignee: The Regents of the University of CaliforniaInventors: Robert James Debs, Ning Zhu
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Patent number: 5820855Abstract: Novel insecticidal compositions are described which are particularly effective against insect pests such as cockroaches, ants, termites, crickets, flies and the like, which contain an effective amount of insecticide and a synergistic effective amount of water powder. The compositions, preferably using boric acid as an insecticide, and preferably in the form of a paste or dust bait, kill such pests more quickly or allow lower concentrations of insecticide to be used in such compositions.Type: GrantFiled: June 17, 1994Date of Patent: October 13, 1998Assignee: Ecolab Inc.Inventors: Stephen John Barcay, Douglas G. Anderson
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Patent number: 5798112Abstract: A phototoxic insecticidal composition includes at least one photoactive dye, an attractant bait composition and/or feeding stimulant and at least one adjuvant, whereby the adjuvant interacts with the photoactive dye and insect membranes to alter the toxicity of the composition once ingested by the insect. More specifically, the composition is directed to killing the Mexican fruit fly.Type: GrantFiled: September 26, 1996Date of Patent: August 25, 1998Assignees: The United States of America as represented by the Secretary of Agriculture, Photodyne International Inc.Inventors: James R. Heitz, Robert L. Mangan, Daniel S. Moreno
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Patent number: 5783454Abstract: The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt.Type: GrantFiled: May 9, 1995Date of Patent: July 21, 1998Inventors: Julian E. Spallholz, Ted W. Reid
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Patent number: 5750128Abstract: A solid pesticide composition is taught which includes a solid carrier, a pesticide and an amount of flour and/or starch to promote the dispersion of the pesticide into the wax. The solid carrier includes paraffin oil, paraffin wax and microcrystalline wax. A solid pesticide composition is provided without having to include a chemical surfactant.Type: GrantFiled: February 16, 1996Date of Patent: May 12, 1998Assignee: Weed-Master Western Inc.Inventor: Peter O. Paulson
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Patent number: 5750130Abstract: Granular pesticide compositions wherein a pesticide material is applied to a granular substrate using a carrier composition which provides improved adhesion of the pesticide to the substrate and abrasion resistance. The carrier composition may also provide controlled release of the pesticide.Type: GrantFiled: August 9, 1996Date of Patent: May 12, 1998Inventors: Paul Ferrell, Alice P. Hudson
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Patent number: 5711954Abstract: A stable powder composition comprising an anti-fungal effective amount of an imidazole antifungal compound and talc coated with a hydrophobic coating is described. A method for stabilizing an imidazole antifungal compound in a talc composition is also described which comprises either using talc coated with a hydrophobic coating or coating talc with a hydrophobic coating, prior to adding the imidazole antifungal compound to the talc.Type: GrantFiled: March 7, 1995Date of Patent: January 27, 1998Assignee: Schering-Plough HealthCare Products, Inc.Inventors: Don C. Beer, Vijay B. Surpuriya
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Patent number: 5711965Abstract: An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.Type: GrantFiled: February 21, 1996Date of Patent: January 27, 1998Assignee: A. Natterman & Cie. GmbHInventors: Miklos Ghyczy, Joachim Roding, Hans Lautenschlager, Walter Hameister, Jorg Hager
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Patent number: 5709872Abstract: A method for deodorizing toilets, and in particular the flushing fluid in a closed toilet system, comprises the use of phospholipids in the fluid to kill or inhibit odor-causing microbes.Type: GrantFiled: October 20, 1995Date of Patent: January 20, 1998Assignee: Chemia CorporationInventor: Norman A. Van Rees
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Patent number: 5700475Abstract: Flowable composites are disclosed which comprise a) microcapsules comprising one or more non-aqueous pesticidally active compositions enclosed in an inert water-soluble wall material; b) a non-aqueous liquid in an amount sufficient to maintain the composite flowable; the non-aqueous pesticidally active composition and the non-aqueous liquid being reactive with each other and the inert water-soluble wall material being insoluble in and impermeable to the non-aqueous liquid and the pesticidally active composition. Also disclosed are composites in which the pesticidally active compositions are internally-reactive in the presence of a non-aqueous liquid or solvent. Processes for production of the composites and their utilization as pesticides are also disclosed.Type: GrantFiled: December 29, 1995Date of Patent: December 23, 1997Assignee: Monsanto CompanyInventors: Brent D. Massman, Maria L. Miller
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Patent number: 5698210Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.Type: GrantFiled: May 2, 1995Date of Patent: December 16, 1997Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Patent number: 5651975Abstract: The invention relates to a method of producing granular mixtures which contain herbicides known per se, the activator used being a solid composition in which the activator ingredients are either impregnated into and/or mixed with a carrier material.Type: GrantFiled: February 15, 1996Date of Patent: July 29, 1997Inventors: Pontus Harju-Jeanty, Ari Juppo
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Patent number: 5651978Abstract: An antibacterial composition having a heat-resistant property sufficient for avoiding its decomposition or discoloration at the resin molding temperature comprises; a silver thiosulfate complex salt carried on silica gel particles having an equilibrium water content of 10% or smaller, wherein at least part of the surface of the silica gel particles carrying said silver thiosulfate complex salt is covered with a coating layer composed of silicon dioxide formed by means of hydrolysis of an alkoxysilane.Type: GrantFiled: August 2, 1996Date of Patent: July 29, 1997Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Toshikazu Tomioka, Katsumi Tomita, Hiroaki Oka, Kenji Hoshino, Atsushi Nishino
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Patent number: 5650218Abstract: A soft tissue product is disclosed having uniformly distributed surface deposits of a solidified composition having a melting point of from about 30.degree. C. to about 70.degree. C. The solidified composition is applied to the outer surfaces of the tissue product in melted form, preferably by rotogravure printing. The solidified composition contains an oil, a wax, and preferably a fatty alcohol.Type: GrantFiled: April 16, 1996Date of Patent: July 22, 1997Assignee: Kimberly-Clark CorporationInventors: Duane Gerard Krzysik, Lee Patrick Garvey, Cynthia Watts Henderson, Michael Chauncey Tuck
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Patent number: 5643592Abstract: Finely-divided particulate additives for polymers with a surface coating comprised of a compound selected from the group consisting of esters of difunctional C.sub.6 -C.sub.40 aliphatic and aromatic carboxylic acids and triesters of phosphoric acid.Type: GrantFiled: August 22, 1994Date of Patent: July 1, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventors: Howard Wayne Jacobson, Joseph V. Kurian, Scott Thomas Sackinger, Chandrakant Shantilal Shah
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Patent number: 5639465Abstract: This invention comprises a granular pesticidal composition having improved attrition resistance comprising from about 10 to about 20% by weight of a pesticide, a glycol or polyvinyl alcohol, the remainder comprising montmorillonite or kaolin clay granules.Type: GrantFiled: August 24, 1995Date of Patent: June 17, 1997Assignee: Zeneca LimitedInventors: Candice W. Huang, Kang-Chi Lin
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Patent number: 5635357Abstract: Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.Type: GrantFiled: November 22, 1994Date of Patent: June 3, 1997Assignee: Becton, Dickinson and CompanyInventors: Adrien Malick, Hans H. Feindt
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Patent number: 5589195Abstract: A proteinaceous emulsion and method for making a proteinaceous emulsion comprising a lipophilic phase, an aqueous phase and a protein emulsifier; which is capable of forming a thin film and has the capability of carrying active ingredients contained in either or both the aqueous phase and the lipophilic phase of the emulsion.Type: GrantFiled: March 21, 1994Date of Patent: December 31, 1996Assignee: Nurture, Inc.Inventor: Richard C. Potter
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Patent number: 5587362Abstract: A compound, and a pharmaceutical composition comprising an effective mount to treat HBV or EBV of a compound, of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, or alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: January 28, 1994Date of Patent: December 24, 1996Assignees: Univ. of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Qing Yao
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Patent number: 5567688Abstract: A method for the treatment of a human infected with HBV that includes administering an HBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: June 6, 1995Date of Patent: October 22, 1996Assignees: Univ. of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Oing Yao
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Patent number: 5565438Abstract: A method for the treatment of a human infected with EBV that includes administering an EBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is 5-methyluracil, and R' is hydrogen, acyl, alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: June 6, 1995Date of Patent: October 15, 1996Assignees: University of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Oing Yao