Membrane Or Diffusion Barrier Patents (Class 424/424)
  • Patent number: 10820844
    Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: November 3, 2020
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Axel Scherer, Arti Gaur
  • Patent number: 10821282
    Abstract: Disclosed herein is an implantable medical device for implantation against cardiac tissue in the administration of electrotherapy to the cardiac tissue. The device includes a distal end and a monolithic controlled release device. The distal end includes a housing structure and a cavity within the housing structure. The cavity opens exterior the implantable medical device via a distal opening. The monolithic controlled release device is within the cavity and proximal the distal opening. The monolithic controlled release device includes a distal face, a proximal face opposite the distal face, an outer circumferential surface extending between the distal face and the proximal face, and a spline-shaped inner lumen extending between the distal face and the proximal face and radially inward from the outer circumferential surface. The monolithic controlled release device further includes an active pharmaceutical ingredient.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: November 3, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Tyler J. Strang, Benjamin F. James, IV, Matthew Malone
  • Patent number: 10751280
    Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: August 25, 2020
    Assignee: NanoVault Medical LLC
    Inventors: Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster
  • Patent number: 10716921
    Abstract: Disclosed are sheaths that comprise a first sheath member having a first passageway, a first length, and a first proximal end defined by a first valve apparatus configured to seal the first passageway, the first passageway having a first passageway diameter at a location in the first passageway; and a second sheath member coupled to the first sheath member, the second sheath member having a second passageway and a second length, the second passageway having a second passageway diameter at a location in the second passageway; where the first passageway and the second passageway are separate from each other and not co-axial, the first length is different from the second length, and the first and second sheath members are positioned beside each other for a portion of their first and second lengths.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: July 21, 2020
    Assignee: Endophys Holdings, LLC
    Inventor: Phillip D. Purdy
  • Patent number: 10617797
    Abstract: The invention relates to the field of biotechnology and medicine, more precisely, to manufacturing technique of implantable medical devices (stents) containing organic lanthanum compound-based X-ray contrast agents distributed within the coating. The objective of this invention is the development of a biocompatible (and biodegradable) polymeric coating with glycolane on the surface of polymeric biodegradable vascular stents and other polymeric implants, which ensures, by means of introduction into a stent, satisfactory radiopacity both during stent installation in a patient and after installation, with a simultaneous additional positive effect provided by therapeutic properties of glycolane.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 14, 2020
    Assignee: LIMITED LIABILITY COMPANY “BIOSTEN”
    Inventors: Alla Nikolaevna Generalova, Anna Igorevna Prostyakova, Igor Ivanovich Pashkin, Vitaly Pavlovich Zubov, Dmitry Valeryevich Kapustin
  • Patent number: 10618998
    Abstract: This invention provides poly(alkylene carbonate)-based amphiphilic block copolymers, compositions comprising the same, e.g., micelles, and methods of use thereof. This invention further provides methods for preparing the poly(alkylene carbonate)-based amphiphilic block copolymers of the invention.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: April 14, 2020
    Assignee: Purdue Research Foundation
    Inventors: You-Yeon Won, Seunggweon Hong, Hoyoung Lee, Jaeyoung Park, Jaewon Lee
  • Patent number: 10617300
    Abstract: Provided are implantable or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate and device component supported by the substrate. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In particular, device thicknesses are less than 1 mm and have lateral dimensions between about 1 m and 10 mm, depending on the application. Delivery substrates may be incorporated to assist with device implantation and handling. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 14, 2020
    Assignees: The Board of Trustees of the University of Illinois, Washington University
    Inventors: John A. Rogers, Michael Raymond Bruchas, Robert Gereau, Jordan Gary McCall, Daniel Brenner, Tae-il Kim, Gunchul Shin, Jaewoong Jeong
  • Patent number: 10588350
    Abstract: An electronic cigarette includes an atomizer having a coil-less heating element having a heating section, two leads electrically connected to the heating section, and a liquid guiding structure. The liquid guiding structure includes two pads, a first pad and a second pad sandwiching at least a portion of the heating section. A gasket may be placed between a liquid supply and the first pad such that liquid is conducted from the liquid supply to the first pad.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: March 17, 2020
    Assignee: FONTEM HOLDINGS 1 B.V.
    Inventors: Fucheng Yu, Zhuoran Li
  • Patent number: 10575925
    Abstract: A method of forming an orthodontic aligner from an aligner digital model, the method comprising the steps of: (a) three-dimensionally printing an intermediate structure comprising fused filaments from a biocompatible thermoplastic according to the aligner digital model via fused deposition modelling; (b) coating the intermediate structure with a biocompatible translucent photopolymer; and (c) irradiating the coating with ultraviolet light to cure the coating on the intermediate structure, thereby forming the orthodontic aligner.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 3, 2020
    Assignee: Structo Pte Ltd
    Inventors: Hubertus Theodorus Petrus Van Esbroeck, Devansh Sharma, Siu Hon Lam, Kah Fai Chin, Boyle Suwono
  • Patent number: 10524895
    Abstract: There is disclosed a collagen construct comprising a plurality of elongate strips, wherein each strip contains a plurality of collagen fibres that are substantially aligned along the length of the respective strips, and the strips are braided or woven together to produce a collagen construct in the form of a rope that can be used for replacing tendons or ligaments, such as cruciate ligaments. Also disclosed is a method for making or producing the collagen construct from a collagen membrane having a plurality of collagen fibres being substantially aligned parallel to each other in a common direction. The membrane is cut along cut lines that are orientated substantially parallel to that common direction, thereby to separate elongate strips from the membrane. The strips are then braided or woven together to form the collagen construct.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: January 7, 2020
    Assignee: Orthocell Limited
    Inventor: Ming Hao Zheng
  • Patent number: 10517698
    Abstract: A method for securing a dental implant within a dental bone cavity is disclosed. The method may include inserting a dental wedge into the dental bone cavity and allowing bone tissues to grow toward and at least partially surround the dental wedge. Dental implantation systems for implementing the method are also disclosed. The system can include a dental wedge adapted to be inserted into a dental bone cavity.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: December 31, 2019
    Assignee: Zimmer Dental, Inc.
    Inventors: Suneel Ranga Sai Battula, Hai Bo Wen, Eneetra Patrice Livings, Michael Scott Collins
  • Patent number: 10517816
    Abstract: An orifice-free drug delivery device is provided. In an embodiment, the device includes a body having at least one water-permeable wall bounding a reservoir defined within the body. A drug formulation is disposed within the reservoir. The body has an elastic portion and at least one restraining plug closing off an opening of the body. The opening is in fluid communication with the reservoir, and the restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more microchannels between the elastic portion of the body and the at least one restraining plug. The elastic portion may define an opening having an inner diameter, which is exceeded by the outer diameter of the restraining plug by at least 3%.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: December 31, 2019
    Assignee: TARIS BIOMEDICAL LLC
    Inventor: Heejin Lee
  • Patent number: 10441528
    Abstract: The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 15, 2019
    Assignee: INTARCIA THERAPEUTICS, INC.
    Inventors: Thomas R. Alessi, Karling Alice Leung, Ryan D. Mercer, Cristina G. Negulescu, Catherine Manya Rohloff, Bing Yang
  • Patent number: 10433892
    Abstract: Provided is a material for preventing bone cement from leaking out from bone during packing of the bone cement into a bone fracture site. The bone cement can be prevented from leaking out from the bone by employing a three-dimensional structure produced from a material containing a polyhydroxyalkanoate, when packing the bone cement into the bone fracture site.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: October 8, 2019
    Assignees: National University Corporation Nagoya University, National University Corporation Nagoya Institute of Technology
    Inventors: Hitoshi Hirata, Takanobu Nishizuka, Tadahiro Natsume, Toshihiro Kasuga
  • Patent number: 10383977
    Abstract: Polymeric grafts for treating damaged biological tissue that are formed from poly(glycerol sebacate) (PGS). The PGS grafts preferably comprise a bioactive agent comprising anti-inflammatory corticosteroids, anti-oxidants, anti-thrombotic agents and anti-platelet agents. The PGS grafts can also comprise a HMG-CoA reductase inhibitor.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: August 20, 2019
    Assignee: CorMatrix Cardiovascular, Inc
    Inventor: Robert G Matheny
  • Patent number: 10301376
    Abstract: Provided are combinations, compositions and kits containing a immune globulin (IG) composition and a soluble hyaluronidase composition formulated for subcutaneous administration. Such products can be used in methods of treating IG-treatable diseases or conditions. Also provided are methods for subcutaneous administration of immune globulin whereby the dosing regimen is substantially the same as for intravenous administration of the same dosage for treatment of the same IG-treatable disease or condition.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: May 28, 2019
    Assignees: Baxalta GmbH, Baxalta Incorporated
    Inventors: Richard Schiff, Heinz Leibl
  • Patent number: 10280265
    Abstract: A method can selectively prepare a compound of formula (IV), where each R1 and each R2 are independently selected from an alkyl group, an aryl group, a halogenated alkyl group, or a halogenated aryl group of 6 to 10 carbon atoms each R3 is an alkane-diyl group, and each R4 is hydrogen or an alkyl group. The method involves hydrosilylation of an organohydrogensiloxane oligomer with a carboxylic acid alkenyl ester using an iridium complex catalyst.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: May 7, 2019
    Assignee: Dow Corning Corporation
    Inventors: Donald Eldred, Matthew Jeletic, Ryan Christopher Thomas
  • Patent number: 10272116
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: April 30, 2019
    Assignee: OSIRIS THERAPEUTICS, INC.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10265344
    Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: April 23, 2019
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10245353
    Abstract: A hydrophilic electrospinning biological composite scaffold material used for tissue regeneration and a preparation method and an application thereof are provided. Fibrinogen, L-arginine or an aqueous solution of hydrochloride thereof and a P(LLA-CL) solution are blended and an electrospinning technology is used to prepare the biological composite scaffold material. The biological composite scaffold material has an equilibrium contact angle that is less than 55°, is hydrophilic and has a good application prospect in repairing body tissue defects.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: April 2, 2019
    Assignee: Shanghai P & P Biotech Co., Ltd
    Inventors: Hongbing He, Ling Su, Zhang Liu, Li Yang
  • Patent number: 10188602
    Abstract: A drug delivery system is provided in the form of a controlled release, bioerodible pellet for subdermal implantation. The pellet is bioerodible, and provides for the sustained release of a pharmacologically active agent over an extended time period. As such, the drug delivery system finds significant utility in chronic drug administration. Bioerosion products are water soluble, bioresorbed, or both, obviating the need for surgical removal of the implant. Methods for manufacturing and using the drug delivery system are also provided.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 29, 2019
    Assignee: GESEA BIOSCIENCES INC.
    Inventors: John H. Baillie, Ruth Baillie, George Blouin, Newsha Farahani, Christopher Marx
  • Patent number: 10166128
    Abstract: The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: January 1, 2019
    Assignee: W. L. Gore & Associates. Inc.
    Inventors: Joseph R. Armstrong, Edward H. Cully, Jeffrey B. Duncan, Mark Y. Hansen, William D. Montgomery, Wendy J. Terry
  • Patent number: 10123971
    Abstract: The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 13, 2018
    Assignee: Titan Pharmaceuticals, Inc.
    Inventors: Rajesh A. Patel, Sunil R. Bhonsle
  • Patent number: 10111830
    Abstract: The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: October 30, 2018
    Assignee: TITAN PHARMACEUTICALS, INC.
    Inventors: Rajesh A. Patel, Sunil R. Bhonsle
  • Patent number: 10092676
    Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: October 9, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Nicholas J. Amoroso, Stephen Francis Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
  • Patent number: 10092672
    Abstract: An air filtration media for use with a heating ventilation and air condition (HVAC) system is provided. The filtration media comprises an air filter media layer having a first and second side, a PCO media layer having a first and second side, and a barrier layer positioned between the second side of the air filter media layer and the first side of the PCO media layer. The air filter media layer, barrier layer, and PCO layer are pleated together and enclosed within a frame for placement adjacent a light source within a plenum of the HVAC system.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: October 9, 2018
    Assignee: Lennox Industries Inc.
    Inventors: Sanjeev Hingorani, Thomas Wolowicz, Henry Greist
  • Patent number: 10092507
    Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
    Type: Grant
    Filed: June 6, 2015
    Date of Patent: October 9, 2018
    Assignee: NanoVault Medical LLC
    Inventors: Willard W. Hennemann, Bryan L. Steelman, Thomas J. Webster
  • Patent number: 10092687
    Abstract: This is to provide a blood filter comprising a porous element; and a copolymer which exists in at least a part of a surface of the porous element, and which contains a recurring unit containing an organic group of the following formula (a) and a recurring unit containing an organic group of the following formula (b), wherein Ua1, Ua2, Ub1, Ub2 and Ub3, and An? are as defined in the present specification and the claims.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: October 9, 2018
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Tatsuro Kanaki, Takahiro Kishioka, Taito Nishino, Yoshiomi Hiroi, Ayako Otani, Tomoyuki Ozawa
  • Patent number: 10035917
    Abstract: A composition for the creation of a protective barrier on a wide variety of materials to prevent the deterioration and degradation caused by exposure to moisture and sun over time.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: July 31, 2018
    Inventor: David Walden
  • Patent number: 10016464
    Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: July 10, 2018
    Assignee: Wake Forest University Health Sciences
    Inventors: Sean V. Murphy, Aleksander Skardal, Anthony Atala
  • Patent number: 9931116
    Abstract: A tissue buttress is provided on at least a first and second jaw of a surgical stapling apparatus. The tissue buttress comprises an electrophilic component and a nucleophilic component. At least a portion of the tissue buttress may be disposed within either or both of the staple pockets and staple forming pockets, securing the tissue buttress to at least one of the staple jaws.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: April 3, 2018
    Assignee: COVIDIEN LP
    Inventors: Danyel Racenet, Steven L. Bennett, Erik Carlson, Kenneth H. Whitfield, Gregg Krehel
  • Patent number: 9883944
    Abstract: A surgical implant, which in use, provides a barrier between layers of tissue such that tissue on one side of the implant does not adhere to tissue on the other side, the implant being made of suitably anatomically shaped surgically acceptable sheet material.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: February 6, 2018
    Assignee: SCIMOTANA PTY LTD
    Inventors: Andrew Batty, Paul D'Urso
  • Patent number: 9795573
    Abstract: A multi-step stabilization method for connective tissue is described. Stabilized tissues can exhibit increased resistance to degradation due to enzyme activity, fatigue and storage. The multi-step method includes a first step during which the tissue can be incubated with a glycosaminoglycanase inhibitor such as a sulfated oligosaccharide, one example of which being neomycin, a second step during which the tissue can be incubated with a crosslink activator such as a carbodiimide crosslink activator and/or a crosslinking agent such as a heterobifunctional crosslinking agent and/or a phenolic compound such as a tannin, examples of which include tannic acid and pentagalloylglucose, and a third step during which the tissue can be incubated with a second crosslink activator that can be the same or different as the first crosslink activator.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: October 24, 2017
    Assignee: Clemson University
    Inventors: Naren Vyavahare, Hobey Tam
  • Patent number: 9795679
    Abstract: Simple mixing/blending of a special class of drug-depot forming tri-block copolymers polymers, with the opportunity to cost-effectively tailor drug delivery performances of such biodegradable, injectable depots in a clinical and an industrial setting. How to visualize these depots for various imaging related purposes is described.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: October 24, 2017
    Assignee: INGELL TECHNOLOGIES HOLDING B.V.
    Inventors: Audrey Petit, Peter Bruin, Mike De Leeuw, Ronald Meijboom
  • Patent number: 9697332
    Abstract: Methods and systems for providing therapy related data management are provided. The subject systems include one or more device components, and at least one memory storage unit and at least one data storage unit associated with such one or more device components. The device components may include one or more of an analyte monitoring system, a fluid delivery device and a remote terminal. The subject methods include use of the subject systems to optimize treatment of a patient.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: July 4, 2017
    Inventor: R. Curtis Jennewine
  • Patent number: 9670447
    Abstract: The present disclosure is directed to embodiments of microstructured membranes, methods of fabricating microstructured membranes, bioreactors housing microstructured membranes, and methods of using bioreactors and microstructured membranes. In some embodiments, the present disclosure allows culturing of cellular tissues in an environment which more accurately resembles a native environment. In some more specific embodiments, the present disclosure allows culturing of tumor cells on a membrane having a microfabricated pattern which mimics a native vasculature system.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: June 6, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Chandan Das, Ashley A. Jaeger, Thomas J. Pohida, Michael M. Gottesman, Randall H. Pursley, Philip G. McQueen, Nicole Y. Morgan
  • Patent number: 9656001
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 23, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • Patent number: 9622777
    Abstract: A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either within the brain. Once positioned at a desired location, the obturator is removed, leaving a distal end of the outer sheath adjacent an area of interest, and creating a working corridor. Interventional devices may be introduced to the area of interest, as well as a variety of treatments. A subsequent treatment process may also be employed.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 18, 2017
    Assignee: Nico Corporation
    Inventors: Joseph L. Mark, Amin Kassam
  • Patent number: 9611353
    Abstract: Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(8-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised of polymers with high levels of bioactive or diagnostic agents.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: April 4, 2017
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Ashim K. Mitra, Sulabh P. Patel, Ravi D. Vaishya, Vibhuti Agrahari
  • Patent number: 9572889
    Abstract: The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 21, 2017
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Thomas R. Alessi, Karling Alice Leung, Ryan D. Mercer, Cristina G. Negulescu, Catherine M. Rohloff, Bing Yang
  • Patent number: 9498156
    Abstract: A sensor (e.g., an optical sensor) that may be placed within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid) within the animal. The sensor may include a sensor housing and a polymer graft including indicator molecules and covering at least a portion of the sensor housing. The opacity of the polymer graft may remain substantially the same (i.e., may have little or no variation) over time. The sensor may include a photodetector, and variation in the opacity of the polymer graft does not cause a significant change in a measurement signal output by the photodetector. The polymer hydrogel may be made of polymers including acrylic acid and/or polyethylene glycol.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: November 22, 2016
    Assignee: Senseonics, Incorporated
    Inventors: Todd Whitehurst, Philip Huffstetler
  • Patent number: 9481865
    Abstract: Disclosed is a serum-free freezing medium used in adipose-derived stem cells and a method for establishing an adipose-derived stem cell library. The serum-free freezing medium comprises a serum-free culture medium, dimethyl sulfoxide and a serum substitution component KSR; the defects of unstable freezing quality of the adipose-derived stem cells and influence of harmful factors in serum on the adipose-derived stem cells are solved, and the adipose-derived stem cells stored have the advantages of high survival percentage, well adherence growth and strong differentiation capacity.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: November 1, 2016
    Assignees: Cellular Biomedicine Group (Shanghai) Ltd, Cellular Biomedicine Group (Wuxi) Ltd
    Inventors: Helen Zhang, Luyi Zhang, Wei Cao
  • Patent number: 9452083
    Abstract: A bioresorbable drug eluting intravitreal implant system includes a syringe with a chamber containing a medicinal drug. A balloon is releasably secured to a needle where the needle has a central section chamber in fluid communication with a chamber in the syringe. The needle central section has an opening formed through a wall for transporting the medicinal drug to the interior of the balloon subsequent to insertion of the needle through the sclera of a patient's eye.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: September 27, 2016
    Assignee: Drug Delivery Company, LLC
    Inventors: Jeffrey D. Benner, Steven M. Cohen
  • Patent number: 9446168
    Abstract: A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: September 20, 2016
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Uriel Barkai, Avi Rotem, Yehezkel Bremer, Tova Neufeld
  • Patent number: 9446226
    Abstract: Composite structures composed of a fibril core and a polymeric coat and designed capable of encapsulating both hydrophobic and hydrophilic bioactive agents while retaining the activity of these agents are disclosed. Further disclosed are processes of preparing such composite structures, and medical devices and disposable articles made therefrom.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: September 20, 2016
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventor: Meital Zilberman
  • Patent number: 9445941
    Abstract: A bioresorbable drug eluting intravitreal implant system includes a syringe with a chamber containing a medicinal drug. A balloon is releasably secured to a needle where the needle has a central section chamber in fluid communication with a chamber in the syringe. The needle central section has an opening formed through a wall for transporting the medicinal drug to the interior of the balloon subsequent to insertion of the needle through the sclera of a patient's eye.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: September 20, 2016
    Assignee: Drug Delivery Company, LLC
    Inventors: Jeffrey D. Benner, Steven M. Cohen
  • Patent number: 9408986
    Abstract: A method of purifying at least one of THC and CBD from a cannabis-containing composition includes heating the cannabis-containing composition to a temperature sufficient to volatilize at least one of THC and CBD into a vapor and condensing the vapor on a substrate. A drug delivery cartridge includes a substrate coated with at least one of THC and CBD and configured to allow for passage of air through the cartridge to volatilize at least one of THC and CBD for inhalation by a user to induce a medicinal or therapeutic effect to the user.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: August 9, 2016
    Inventor: Timothy McCullough
  • Patent number: 9393272
    Abstract: Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 19, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel C. Opara, Benjamin S. Harrison
  • Patent number: 9387068
    Abstract: A self-sealing shell useful as a component of a soft fluid-filled prosthetic implant is provided. The shell is at least partly constructed of a wall made of a colloid of an elastomeric polymer matrix and particles of a water-swellable material distributed therein.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: July 12, 2016
    Assignee: Allergan, Inc.
    Inventor: David Schuessler
  • Patent number: 9387279
    Abstract: A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: July 12, 2016
    Assignee: The Governing Council of the University of Toronto
    Inventors: Xiao Yu Wu, Kai Zhang, Huiyu Huang, Claudia Gordijo, Jason Siu-Wei Li, Michael K.L. Chu