Diffusion Barrier Is Matrix Patents (Class 424/425)
  • Patent number: 10364141
    Abstract: Block copolymer nanostructures such as nanosheets, nanoribbons, and nanotubes, are provided. The nanotructures are formed by the self-assembly of block copolymers during evaporation of solvent from a sol that has been “disturbed”, either i) internally by the introduction of relief (e.g. curvature) and/or the inclusion of nanoparticles in the sol; or ii) externally, e.g. by physical deformation of a semi-solid form of the sol, or a combination of internal and external disturbance. The nanostructures have uses in, for example, energy devices, electronics, sensors and drug delivery applications.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 30, 2019
    Assignee: WASHINGTON STATE UNIVERSITY
    Inventors: Yu Wang, Wei-hong Zhong
  • Patent number: 10342706
    Abstract: Disclosed are compositions that comprise an organic electrochemical mediator and a gasotransmitter salt which converts into a gasotransmitter via electron transfer. Also disclosed are bandages and wound dressings comprising the subject gasotransmitters, and methods of making a gasotransmitters, comprising exposing the compositions to a voltage sufficient to reduce the water soluble organic mediator. Further disclosed are methods of treating a variety of trauma and disease states by applying a therapeutically effective amount of at least one gasotransmitter thereto, and methods of generating an effective dose of the gasotransmitter generated from electrolytic reaction involving the gasotransmitter-generating compositions.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: July 9, 2019
    Assignee: Noxsano Inc.
    Inventors: Alan Willey, Stevan Samuel
  • Patent number: 10329386
    Abstract: Provided is a self-restoring macromolecular material that not only has excellent stress relaxation but that can also be easily restored to its original state, even when damaged or severed. Also provided is a method for producing the self-restoring macromolecular material. The self-restoring macromolecular material contains a crosslinked structure that is formed by crosslinking a polymer containing at least a polyrotaxane molecule. The polyrotaxane molecule is formed so as to include a cyclic molecule 21 and a linear molecule that passes through an opening 21a of the cyclic molecule. The crosslinked structure 1 is crosslinked via a reversible bond between the cyclic molecule of the polyrotaxane molecule and a polymer molecule other than the polyrotaxane molecule.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 25, 2019
    Assignee: Osaka University
    Inventors: Akira Harada, Yoshinori Takashima, Yuichiro Kobayashi, Masaki Nakahata, Shoko Mori
  • Patent number: 10314939
    Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: June 11, 2019
    Assignee: Orthocell Pty Ltd
    Inventor: Ming Hao Zheng
  • Patent number: 10279081
    Abstract: Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: May 7, 2019
    Assignee: ALLOSOURCE
    Inventors: Adrian C. Samaniego, Matthew Southard, Kenneth Blood
  • Patent number: 10251954
    Abstract: Some aspects of this disclosure relate to a method of treating an ophthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel for controlled release of a therapeutic agent.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: April 9, 2019
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, William H. Ransone, II
  • Patent number: 10232086
    Abstract: Disclosed are composites comprising water-soluble polymeric fibers dispersed in a biodegradable polymer matrix, as well as methods of making and using such composites.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 19, 2019
    Assignee: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Carlos A Cruz
  • Patent number: 10159744
    Abstract: The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: December 25, 2018
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 9867786
    Abstract: A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: January 16, 2018
    Assignee: AUXILIUM US HOLDINGS, LLC
    Inventors: Michael M. Crowley, Justin M. Keen, John J. Koleng, Feng Zhang
  • Patent number: 9808500
    Abstract: The present invention encompasses an antithrombotic nanoparticle and use thereof.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 7, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel A. Wickline, Jacob Myerson, Rohun Palekar, Hua Pan
  • Patent number: 9808484
    Abstract: The invention relates to an anti-inflammatory composition comprising: 53 wt.-% maltodextrin in relation to the total weight; 10-12 wt.-% zinc oxide as a thixotropic agent; 1.8 wt.-% maltose; 0.0002 wt.-% sodium; 0.0002 wt.-% potassium; 0.0002 wt.-% calcium; 0.0002 wt.-% phosphor; and 0.0006 wt.-% magnesium. The composition has an application viscosity in the range of 12,000-33,000 cp, a pH of between 5.6 and 6.9, a TGA of 61.12 and bond strength at 24 hours of 6 MPa.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: November 7, 2017
    Assignee: Pebisut De Mexico S.A. DE C.V.
    Inventor: Jorge Cueto Garcia
  • Patent number: 9778154
    Abstract: In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and optically-transparent, thereby exposing their cellular structure with intact connectivity. In some embodiments, the present application teaches PACT, a protocol for passive tissue clearing and immunostaining of intact organs. In other embodiments, the present application teaches RIMS, a refractive index matching media for imaging thick tissue. In yet other embodiments, the application teaches PARS, a method for whole-body clearing and immunolabeling.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: October 3, 2017
    Assignee: California Institute of Technology
    Inventors: Viviana Gradinaru, Bin Yang
  • Patent number: 9707251
    Abstract: Two siloxane-based mixtures combine to form a soft or semi-solid matrix for forming an artificial blockage to control bleeding, particularly moderate to severe bleeding. The first component includes a homogeneous mixture or solution that includes a polymeric matrix, a surfactant, filler(s) and metal compound(s). The second component includes a homogeneous mixture or solution that includes a polymer(s), a filler(s), a surfactant, and hydrogen peroxide. The combination of the two components is carried out with adequate mixing using mechanical and micro-kinetic mixing mechanisms and can be performed in a field-ready delivery device.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: July 18, 2017
    Assignee: MATERIALS MODIFICATION, INC.
    Inventors: Kausik Mukhopadhyay, Krishnaswamy Kasthuri Rangan, Tirumalai Srinivas Sudarshan
  • Patent number: 9670289
    Abstract: The present disclosure describes an implant for tissue replacement or augmentation including a resorbable non-pyrogenic porous body of irradiated oxidized cellulose, formed from a precursor reactive mixture of irradiated cellulose and an oxidizing agent, where the body forms a heterogeneous three-dimensional fibrillar network. Also disclosed is a method for producing a body of oxidized cellulose including irradiating a body of cellulose to form an irradiated body of cellulose, and reacting the irradiated body of cellulose with an oxidizing agent to form a non-pyrogenic porous and resorbable body of oxidized cellulose.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: June 6, 2017
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Wojciech Czaja, Dmytro D. Kyryliouk
  • Patent number: 9649209
    Abstract: A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduce the likelihood of the development of restenosis in the coronary arteries. The inner and outer polymeric materials can be of the same polymer or different polymer to achieve different results, such as enhancing flexibility and providing a stent that is visible under MRI, computer tomography and x-ray fluoroscopy.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: May 16, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventor: Santosh Prabhu
  • Patent number: 9592227
    Abstract: Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 14, 2017
    Assignee: Heron Therapeutics, Inc.
    Inventors: Thomas B. Ottoboni, Lee Ann Lynn Schillinger
  • Patent number: 9533001
    Abstract: Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: January 3, 2017
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Georgios T. Hilas, Kenneth David Gray
  • Patent number: 9446036
    Abstract: Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 20, 2016
    Assignee: Heron Therapeutics, Inc.
    Inventors: Thomas B. Ottoboni, Lee Ann Lynn Schillinger, Joseph Niemann
  • Patent number: 9439905
    Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 13, 2016
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Steven Siegel, Karen Winey
  • Patent number: 9409999
    Abstract: The present invention aims to provide a method of producing a hydrophilic modified polyrotaxane, which enables production of a hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step in which the prepared solution of the hydrophilic modified polyrotaxane is formed into a thin film state and dried.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: August 9, 2016
    Assignees: SUMITOMO SEIKA CHEMICALS CO., LTD., ADVANCED SOFTMATERIALS INC.
    Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Yuki Hayashi, Minoru Iwata
  • Patent number: 9370381
    Abstract: The present invention provides a bone connection material that includes an internal layer. The internal layer is formed by braiding a plurality of filaments. The internal layer that is formed by braiding filaments is resistant to lateral shearing forces and may provide flexibility so as to achieve wide applications. Further, the present invention overcomes the drawback of the conventionally used metallic materials that are rigid and inelastic and also overcomes the problem of polylactic acid material of being brittle. Thus, the bone formed according to the present invention is close to a natural bone and is more suitable for uses in portions where frequent movements are made and scaffolds of stem cells.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: June 21, 2016
    Inventors: Luke Lu, Toshihiro Tokizawa, Kuan-Yu Lu, I-Ching Lu
  • Patent number: 9352046
    Abstract: A composition of matter and method for preparation of a tissue augmentation material. A polysaccharide gel composition is prepared with rheological properties selected for a particular selected application. The method includes preparing a polymeric polysaccharide in a buffer to create a polymer solution or gel suspending properties in the gel and selecting a rheology profile for the desired tissue region.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 31, 2016
    Assignee: MERZ NORTH AMERICA, INC.
    Inventors: Robert Voigts, Dale Devore
  • Patent number: 9320686
    Abstract: The invention relates to a dental restorative material which comprises a thermolabile compound of Formula I: [(Z1)m-Q1-X)]k-T-[Y-Q2-(Z2)n]l??Formula I, in which T represents a thermolabile unit which contains at least one thermolabile group based on non-covalent interactions, Z1 and Z2 in each case independently represent a polymerizable group selected from vinyl groups, CH2?CR1—CO—O— and CH2?CR1—CO—NR2— or an adhesive group selected from —Si(OR)3, —COOH, —O—PO(OH)2, —PO(OH)2, —SO2OH and —SH, Q1 in each case independently is missing or represents an (m+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, Q2 in each case independently is missing or represents an (n+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, X and Y in each case independently are missing or represent —O—, —
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: April 26, 2016
    Assignee: Ivoclar Vivadent AG
    Inventors: Norbert Moszner, Thomas Hirt, Kai Rist, Ulrich Salz, Christoph Weder, Gina Fiore, Christian Heinzmann, Volker Rheinberger
  • Patent number: 9266972
    Abstract: The present invention aims to provide a polyrotaxane composition having excellent storage stability. The present invention relates to a polyrotaxane composition comprising: a polyrotaxane containing a cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: February 23, 2016
    Assignees: SUMITOMO SEIKA CHEMICALS CO., LTD., ADVANCED SOFTMATERIALS INC.
    Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao, Minoru Iwata, Yuki Hayashi
  • Patent number: 9259518
    Abstract: A drug-delivering insertable medical device for treating a medical condition associated with a body lumen is disclosed. The drug-delivering insertable medical device includes an outer surface coated with two or more nano-carriers having two or more average diameters. A nano-carrier of the two or more nano-carriers has an average diameter suitable for penetrating one or more layers of two or more layers of the body lumen. The nano-carrier includes a drug surrounded by an encapsulating medium. The encapsulating medium includes one or more of a biological agent, a blood excipient, and a phospholipid.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: February 16, 2016
    Assignee: ENVISION SCIENTIFIC PRIVATE LIMITED
    Inventors: Manish Doshi, Prakash Sojitra, Alexandre Abizaid
  • Patent number: 9238696
    Abstract: The present invention aims to provide a method of producing a powdered hydrophilic modified polyrotaxane, which enables production of a powdered hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: January 19, 2016
    Assignee: Sumitomo Seika Chemicals Co., Ltd.
    Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Yuki Hayashi, Minoru Iwata
  • Patent number: 9132119
    Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: September 15, 2015
    Assignee: Medtronic, Inc.
    Inventors: Christopher M. Hobot, Phillip E. McDonald, Keith R. Hildebrand
  • Patent number: 9125917
    Abstract: Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: September 8, 2015
    Assignees: Warsaw Orthopedic, Inc., Medtronic, Inc.
    Inventors: William F McKay, Christopher M Hobot, Danielle Biggs, Katara Shaw, John Myers Zanella, Vanja M King, Stephen Mark Cox, Kathy L Remsen
  • Patent number: 9072727
    Abstract: Effective treatments of pain and/or inflammation from degenerative disc disease and/or facet joint are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a degenerative disc and/or facet joint, one can reduce, prevent or treat pain and/or inflammation caused by the degenerative disc disease and/or facet joint.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: July 7, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9068051
    Abstract: The present invention aims to provide a method for producing a refined polyrotaxane which includes an industrially advantageous method of producing a polyrotaxane that has excellent storage stability. The method for producing a refined polyrotaxane includes the step of heat-cleaning a polyrotaxane with a cleaning medium, the polyrotaxane containing cyclodextrin molecules, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: June 30, 2015
    Assignees: Sumitomo Seika Chemicals Co., Ltd., Advanced Softmaterials Inc.
    Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao
  • Patent number: 9040080
    Abstract: The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T1 and forming capsules including the active agent. The method may also include melt processing the capsules with a second polymer material exhibiting a second processing temperature T2, wherein T1>T2.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: May 26, 2015
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Hong Dixon, Joseph A McDonough
  • Publication number: 20150140061
    Abstract: Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventor: Chandrashekhar Pathak
  • Patent number: 9034364
    Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: May 19, 2015
    Assignee: Agency for Science, Technology and Research
    Inventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
  • Patent number: 9034378
    Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: May 19, 2015
    Assignee: PolyNovo Biomaterials Pty Ltd
    Inventors: Timothy G. Moore, Raju Adhikari, Pathiraja A. Gunatillake
  • Patent number: 9011964
    Abstract: A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one layer of a protective material having the same core drug or different core drug. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one shell of a protective material with same drug concentration or different drug concentrations. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated such that it has different release schedule than other portions of the drug. Methods and systems for manufacturing and administration of nanosized encapsulated drugs are also provided.
    Type: Grant
    Filed: December 6, 2014
    Date of Patent: April 21, 2015
    Inventor: Albert S. Zeng
  • Patent number: 8986727
    Abstract: A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: March 24, 2015
    Assignee: Delpor, Inc.
    Inventors: Francis J. Martin, Anthony A. Boiarski
  • Patent number: 8980299
    Abstract: A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and randomly orienting the at least one fiber into a fibrous structure having at least one interstitial spaces. Polymeric materials may be utilized to fabricate any of these devices. The polymeric materials may include additives such as drugs or other bioactive agents as well as antibacterial agents. In such instances, at least one agent, in therapeutic dosage, is incorporated into at least one of the fibrous structure and the at least one fiber.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: March 17, 2015
    Assignee: Cordis Corporation
    Inventors: Vipul Bhupendra Dave, Howard Scalzo, Jerome Fischer
  • Patent number: 8968417
    Abstract: Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restauration of the heart conical shape.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: March 3, 2015
    Assignees: Institut Quimic de Sarria, Universitad Politecnica de Valencia, Fundacio Institut d'Investigacio Sanitaria Germans Trias Pujol, Association Cardio-Monde
    Inventors: Juan Carlos Chachques, Antonio Bayes Genis, Manuel Monleon Pradas, Carlos Eduardo Semino, Nicole Zur Nieden, Philippe Jenny
  • Patent number: 8968392
    Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 3, 2015
    Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo Iwata
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 8962023
    Abstract: A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: February 24, 2015
    Assignee: Atrium Medical Corporation
    Inventors: Roger Labrecque, Philip McNamara, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith Faucher, Thomas M. Swanick
  • Patent number: 8951545
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: February 10, 2015
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 8945601
    Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein the porous region exhibits a nano-textured surface, and a biocompatible polymer matrix coating the nano-textured surface. The polymer matrix coating comprises a naturally occurring extracellular matrix with biocompatible inorganic materials distributed within the matrix, or a biocompatible polymer and an osteo-inductive agent.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: February 3, 2015
    Assignees: DePuy Synthes Products, LLC, Purdue Research Foundation
    Inventors: Perla Venu, Prasanna Malaviya, Thomas J. Webster
  • Publication number: 20150024025
    Abstract: Embodiments of the present disclosure provide for aligned nanofibrous polymer matrix structure, structures incorporating aligned nanofibrous polymer matrix structures, methods of using aligned nanofibrous polymer matrix structures, methods of making aligned nanofibrous polymer matrix structures, and the like.
    Type: Application
    Filed: March 6, 2013
    Publication date: January 22, 2015
    Applicant: The UABB Research Foundation
    Inventor: Candace Floyd
  • Patent number: 8911763
    Abstract: A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 16, 2014
    Assignee: Ed. Geistlich Soehne AG fuer Chemistrie Industrie
    Inventors: Peter Geistlich, Lothar Schloesser
  • Patent number: 8911764
    Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: December 16, 2014
    Inventor: Jonathon Z. Zhao
  • Patent number: 8906404
    Abstract: Provided herein is a three dimensional porous structure formed around an array of particles, where the particles define pores in the structure. The structure retreats away from the surface of the particles during formation, such that the particles optionally remain within the pores in the structure.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: December 9, 2014
    Assignee: Spheritech Ltd.
    Inventor: Donald A. Wellings
  • Patent number: 8900618
    Abstract: Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 2, 2014
    Assignee: Covidien LP
    Inventor: Chandrashekhar Pathak
  • Patent number: 8883187
    Abstract: A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: November 11, 2014
    Assignee: Auxilium US Holdings, LLC
    Inventors: Michael M. Crowley, Justin M. Keen, John J. Koleng, Feng Zhang
  • Patent number: 8883186
    Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: November 11, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen Dirk Pacetti
  • Patent number: 8877221
    Abstract: Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: November 4, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay