Errodable, Resorbable, Or Dissolving Patents (Class 424/426)
  • Patent number: 10702539
    Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: July 7, 2020
    Assignee: Allergan, Inc.
    Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
  • Patent number: 10688061
    Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 23, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Naren Vyavahare, Aditi Sinha
  • Patent number: 10682442
    Abstract: The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 16, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: David Puleo, Todd Milbrandt, James Zach Hilt, Paul Fisher, Vishwas Talwalkar
  • Patent number: 10667897
    Abstract: Synthetic polymeric vascular grafts that promote endothelial healing and methods of their preparation and use are provided.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: June 2, 2020
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Le Zhen, Felix Simonovsky, Jonathan Himmelfarb
  • Patent number: 10660842
    Abstract: The disclosure relates to a cosmetic composition for the temporary shaping of hair, containing a combination of an anionic acrylate polymer and an amphoteric polymer. The cosmetic composition provides an extremely good moisture resistance.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: May 26, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Julia Bibiane Lange, Anna Puls, Cyrielle Martinez, Bernd Richters
  • Patent number: 10653689
    Abstract: The invention relates to (among other things) a method comprising the steps of (a) administering to a patient a PARP-inhibiting amount of a PARP inhibitor; and (b) administering to the patient a topoisomerase I-inhibiting amount of a long-acting topoisomerase I inhibitor.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: May 19, 2020
    Assignee: Nektar Therapeutics
    Inventors: Ute Hoch, Nancy Marie Burns, Deborah H. Charych
  • Patent number: 10647093
    Abstract: Disclosed is a biodegradable sheet comprising at least one layer which is a direct contact layer, intended to successfully contact materials, such as liquids, while maintaining the mechanical properties of the sheet and to extend the biodegradable sheet shelf life. The direct contact layer may comprise a hydrophobic polymer selected from poly(epsilon-caprolactone) (PCL) polyhydroxybutyrate (PHB), Polydioxanone (PDO) polyglycolic acid (PGA), polybutylene succinate (PBS), polybutylene succinate adipate (PBSA), poly lactic acid (PLA), polybutylene adipate terphtalate (PBAT), polyhydroxyalkanoates (PHA), such as polyhydroxybutyrates (PHB), polyhydroxyvalerates (PHV), and polyhydroxybutyrate-hydroxyvalerate copolymers (PHBV) or any mixture thereof. The biodegradable sheet may further comprise surface treated nanoclay particles, PVOH grafted with a crosslinker and PBS or PBSA The biodegradable sheet may further include at least one metalized, biodegradable, laminate layer.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 12, 2020
    Assignee: Tipa Corp. Ltd.
    Inventors: Daphna Nissenbaum, Tal Neuman, Dori Pelled, Shai Garty, Nili Konieczny
  • Patent number: 10646572
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 12, 2020
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 10617512
    Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 14, 2020
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • Patent number: 10603412
    Abstract: Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 31, 2020
    Assignees: Versitech Limited, City University of Hong Kong
    Inventors: Hoi Man Karen Wong, Wai Kwok Kelvin Yeung, Man Chee Kenneth Cheung, Dip Kei Keith Luk, Kin On John Lam, Kim Ho Paul Chu
  • Patent number: 10596298
    Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. The second portion of cortical bone is shaved into shavings. The shavings are long thin strips subjected to freeze-drying. The freeze-dried shavings are ground and demineralized and then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 24, 2020
    Assignee: Vivex Biologics Group, Inc.
    Inventors: Edgar S. Maldonado, Silvia Daniela Gonzales
  • Patent number: 10596262
    Abstract: The present invention relates to biomedically useful compositions of C2-C3 linked polyethers of 1,6:2,3-dianhydrohexopyranose derivatives combined with effective amounts of one or more bioactive agents. In certain embodiments the C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivatives are aqueous insoluble. In certain other embodiments biomedically useful compositions have the physical form of microparticles, microspheres, tubes, rods, sheets, membranes, fibers and the like. In certain embodiments the bioactive agent is a protein.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: March 24, 2020
    Assignee: TRGel, LLC
    Inventor: Alexander A Gorkovenko
  • Patent number: 10590236
    Abstract: A process of forming a lactide copolymer includes forming a dimethylidene lactide molecule from an L-lactide molecule. The process also includes forming a functionalized lactide monomer from the dimethylidene lactide molecule. The process includes forming a mixture that includes the functionalized lactide monomer and a bisphenol A (BPA) monomer or a BPA-derived monomer. The process further includes polymerizing the mixture to form a lactide copolymer.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: March 17, 2020
    Assignee: International Business Machines Corporation
    Inventors: Brandon M. Kobilka, Joseph Kuczynski, Jacob T. Porter, Jason T. Wertz
  • Patent number: 10588734
    Abstract: A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a flexible deposited fiber network of varying density including a first and second set of set of electrospun fibers. The second set of electrospun fibers is coupled to the first. A first portion of the flexible deposited fiber network includes a higher density of fibers than a second portion of the flexible deposited fiber network, and the tensile strength of first portion is higher than that of the second portion. The scaffold is sufficiently flexible to facilitate application of scaffold to uneven surfaces of the tissue substrate, and enables movement of the scaffold by the tissue substrate. The first and second set of fibers are configured to degrade within three months after application, and each fiber of the deposited fiber network has a diameter of 1-1000 nanometers.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: March 17, 2020
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • Patent number: 10589451
    Abstract: Apparatus for producing a three dimensional nanofiber structure includes (1) at least two spaced electrodes; (2) a spinner adapted to rotate the at least two spaced electrodes; (3) a syringe assembly adapted to eject a polymer solution from a syringe of the syringe assembly towards the at least two spaced electrodes while the at least two spaced electrodes are rotated by the spinner; and (4) a power supply assembly for providing the two spaced electrodes at a first electric potential, and for providing the syringe at a second electric potential which is different from the first electric potential. A composition of matter may include (1) a least one layer of nanofibers in which a distribution of angles of fibers is “aligned;” and (2) at least one gel layer, wherein the at least one layer of microfibers and the at least one gel layer alternate to form a laminate.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 17, 2020
    Assignee: New York University
    Inventors: Nikita Grigoryev, Kalle Levon
  • Patent number: 10590414
    Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 17, 2020
    Assignee: NORTHEASTERN UNIVERSITY
    Inventors: Ke Zhang, Xueguang Lu
  • Patent number: 10579891
    Abstract: Devices and methods for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.
    Type: Grant
    Filed: February 13, 2016
    Date of Patent: March 3, 2020
    Assignees: AI Biomed Corp, VANDERBILT UNIVERSITY
    Inventors: Adnan Abbas, Melanie McWade, Anita Mahadevan-Jansen
  • Patent number: 10561746
    Abstract: The present invention describes an X-ray contrast composition for local administration, wherein the X-ray contrast composition exhibits contrast properties and wherein at least 60% of an administrated amount of said X-ray contrast composition remains more than 24 hours within 10 cm from an injection point when the X-ray contrast composition is administrated to a human or animal body.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: February 18, 2020
    Assignees: Danmarks Tekniske Universitet, Nanovi Radiotherapy APS
    Inventors: Thomas Lars Andresen, Rasmus Irming Jolck, Morten Albrechtsen
  • Patent number: 10561735
    Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: February 18, 2020
    Assignees: Paladin Labs Inc., Paladin Labs Europe Limited, Paladin Labs (Barbados) Inc.
    Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
  • Patent number: 10561510
    Abstract: Methods and apparatus are disclosed for customizing an elution profile of a stent after manufacture of the stent has been completed. The stent includes a plurality of side ports for eluting a drug formulation within a lumenal space of a hollow strut that forms the stent. An effective diameter of at least one side port of the plurality of side ports of the stent is modified in order to customize an elution profile of the stent. In an embodiment hereof, the plurality of side ports are completely blocked or plugged with a filler material during the manufacture of the stent and at least a portion of the filler material is removed to increase an effective diameter of at least one side port of the plurality of side ports of the stent in order to customize an elution profile of the stent.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 18, 2020
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Shane Nolan, David Hobbins, Michael Sayers, Eamon Keane, Brian Dowling, Jonathan Cope, Conor O'Donovan, Risa Egerter, Lana Woolley, Marc Anderson
  • Patent number: 10532132
    Abstract: A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: January 14, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Irene Sophie Tobias, Heejin Lee, Michael J. Cima, Jordan Dimitrakov
  • Patent number: 10517819
    Abstract: Described are gastric residence structures that include an active substance. The gastric residence structures may include one or more arms that include a loadable polymeric component, an elastic polymeric component, and a separate linker component. The linker may connect the one or more arms with the elastic polymeric component. The gastric residence structures may be configured to be folded and physically constrained during administration and may be configured to assume an open retention shape upon removal of a constraint. The change between the folded shape and the open retention shape may be mediated by the elastic polymeric component that undergoes elastic deformation when the residence structure is in the folded shape and recoils when the gastric residence structure assumes the open retention shape.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: December 31, 2019
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff
  • Patent number: 10512712
    Abstract: Some invention embodiments relate to an implant having a base body composed of a biocorrodible magnesium alloy and a polylactide coating. The implant is characterized in that the coating contains seed crystals and/or lipophilic substances as additives.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: December 24, 2019
    Assignee: BIOTRONIK AG
    Inventors: Bjoern Klocke, Alexander Borck
  • Patent number: 10500304
    Abstract: Embodiments of the present disclosure are directed to perforated polymer films and methods of making the same. In some embodiments, the films are for use with implantable medical devices. In one embodiment there is a flexible body including a polymer film having a first surface and an opposing second surface, the film having a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by a one of the plurality of raised lips. In one embodiment, the film comprises a single layer, and in another embodiment, the film can comprise a plurality of layers. In certain embodiments, the film can comprise an adhesive layer. In another embodiment, one or more of the layers may be a drug containing layer and/or a rate controlling layer for drug release.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: December 10, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: David A. Armbruster, James Dwyer, Jeffrey Chomyn, Sean H. Kerr
  • Patent number: 10500312
    Abstract: Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: December 10, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10500200
    Abstract: Methods, devices, and medicaments that include trospium are provided for use in the treatment of bladder dysfunction by locally administering the trospium into the bladder to achieve a sustained concentration of trospium in urine in the bladder sufficient to produce a therapeutic concentration of trospium in bladder tissue. The drug may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: December 10, 2019
    Assignee: TARIS Biomedical LLC
    Inventor: Dennis Giesing
  • Patent number: 10493024
    Abstract: Disclosed are methods of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a tumescent composition comprising: (a) the drug or the therapeutic agent, wherein a tumescent concentration of the drug is simultaneously: 1) below a threshold for local, subcutaneous tissue toxicity, 2) above a threshold for positive local therapeutic effect, and 3) above a concentration achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier. Some embodiments relate to a method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject. Some embodiments relate to a tumescent solution for treating a localized viral infection, e.g., varicella-zoster (shingles), the tumescent solution comprising an antiviral agent.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 3, 2019
    Assignee: HK TUMESCENT PHARMA CORPORATION
    Inventors: Jeffrey Alan Klein, Paytra Alan Klein
  • Patent number: 10497172
    Abstract: A method for generating three-dimensional facial models and photorealistic textures from inferences using deep neural networks relies upon generating a low frequency and a high frequency albedo map of the full and partial face, respectively. Then, the high frequency albedo map may be used for comparison with correlation matrices generated by a neural network trained by a large scale, high-resolution facial dataset with simulated partial visibility. The corresponding correlation matrices of the complete facial textures can then be retrieved. Finally, a full facial texture map may be synthesized, using convex combinations of the correlation matrices. A photorealistic facial texture for the three-dimensional face rendering can be obtained through optimization using the deep neural network and a loss function that incorporates the blended target correlation matrices.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: December 3, 2019
    Assignee: Pinscreen, Inc.
    Inventors: Shunsuke Saito, Cosimo Wei, Liwen Hu, Hao Li
  • Patent number: 10487134
    Abstract: The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: November 26, 2019
    Assignee: INNOCOLL PHARMACEUTICALS LIMITED
    Inventors: Alexandra Dietrich, Michael Myers
  • Patent number: 10471070
    Abstract: In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: November 12, 2019
    Inventors: Eyal Sheetrit, Izhar Halahmi, Ishay Attar
  • Patent number: 10449152
    Abstract: A microsphere is claimed which includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 22, 2019
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Gary R. Strichartz, Phillip Blaskovich
  • Patent number: 10449214
    Abstract: A gel containing hyaluronic acid in a crosslinked form or in a mixture of a crosslinked and non-crosslinked form is injected into the periosteum of a bone in order to heal and/or regenerate bones or tissue surrounding bones in humans or vertebrates.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: October 22, 2019
    Inventor: Tracey Lennemann
  • Patent number: 10441548
    Abstract: The present invention is a surface treated drug-loaded solid (e.g., non-porous) microparticle that aggregates in vivo to form a consolidated larger particle for medical therapy. In one embodiment, the particles are used for ocular therapy. Processes for producing the surface treated microparticle and injectable formulations which include the surface treated microparticle are also provided. When used in the eye, long-term consistent intraocular delivery can be achieved without disrupting vision and minimizing undesirable inflammatory responses.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: October 15, 2019
    Assignee: Graybug Vision, Inc.
    Inventors: Yun Yu, Joshua Kays, Ming Yang, Jeffrey L. Cleland
  • Patent number: 10441679
    Abstract: In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: October 15, 2019
    Assignee: WARSAW ORTHOPEDIC, INC.
    Inventors: Jeffrey M. Gross, Steve Peckham, Jeffrey L. Scifert, Jeffrey Badura, Nelson Scarborough, Scott Vickers
  • Patent number: 10420855
    Abstract: A surgical sealant comprising a first agent containing a hydrophobically-modified gelatin derived from a cold-water fish, and a second agent containing a water-soluble molecule for crosslinking, wherein the water-soluble molecule for crosslinking is at least one kind selected from the group consisting of poly acids and acid anhydrides having two or more active ester groups, and aldehyde compounds having two or more aldehyde groups, the hydrophobically-modified gelatin derived from a cold-water fish is a gelatin in which at least a part of amino groups of side chains of a gelatin derived from a cold-water fish has been substituted by hydrophobic groups, and the hydrophobic groups are linear chain aliphatic groups each having 8 to 18 carbon atoms, with a substitution rate (number of moles of hydrophobic groups/(total number of moles of hydrophobic groups and reactive amino groups in gelatin)×100) of 3 to 20 mol %.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: September 24, 2019
    Assignee: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventor: Tetsushi Taguchi
  • Patent number: 10405963
    Abstract: The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: September 10, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Michael C. McAlpine, Blake N. Johnson
  • Patent number: 10406168
    Abstract: Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the polymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in an eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 10, 2019
    Assignee: Allergan, Inc.
    Inventors: Patrick M. Hughes, Michele Boix, Christian Sarrazin, Marina Do
  • Patent number: 10406098
    Abstract: An injection solution can be used in a pharmaceutical dosage formulation. The injection solution includes an organic solvent, a copolymer, which is a poly(lactide-co-glycolide) dissolved in the organic solvent, and a pharmaceutical active ingredient, which is a non-nucleoside inhibitor of the HIV reverse transcriptase or of the HIV integrase, and which contains aromatic and heterocyclic aromatic or aromatic and heterocyclic aromatic and aliphatic heterocyclic groups, where a content of the pharmaceutical active ingredient is from about 8 to about 25% by weight of the copolymer solution.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: September 10, 2019
    Assignee: Evonik Roehm GmbH
    Inventors: Norbert Windhab, Rima Jaber, Axel Schroeder, Kevin Burton, Tom Tice
  • Patent number: 10398789
    Abstract: The present invention encompasses a therapeutic method which employs treatment of a disease such as cancer with triiodothyronine (T3) together with an anti-thyroid treatment such as treatment with an anti-thyroid agent, treatment with radioiodine and surgical removal of all or part of the thyroid gland. A pharmaceutical composition comprising T3 and an anti-thyroid agent and a kit comprising the same are also encompassed by the invention.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 3, 2019
    Inventors: Osnat Ashur-Fabian, Aleck Hercbergs
  • Patent number: 10395774
    Abstract: A vascular assessment apparatus is disclosed. The apparatus is configured to receive medical images of a coronary vessel tree of a subject from a medical imaging device and analyze the medical images to identify vessel segments within the coronary vessel tree. For each identified vessel segment, the apparatus is configured to analyze portions of the segment to determine at least one of a radius, diameter, or cross-sectional area of the vessel segment at the analyzed portions, determine resistances for the analyzed portions of the vessel segment based the radius, diameter, or the cross-sectional area at the analyzed portions, and combine the determined resistances for the analyzed portions of the vessel segment to determine a total resistance of the identified vessel segment. The example apparatus is also configured to determine flow rates at each identified vessel segment and calculate an index indicative of vascular function based on the determined flow rates.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: August 27, 2019
    Assignee: Cathworks Ltd
    Inventors: Ifat Lavi, Ran Kornowski, Idit Avrahami, Nessi Benishti, Guy Lavi
  • Patent number: 10369098
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: August 6, 2019
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10363281
    Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 30, 2019
    Assignee: TissueGen, Inc.
    Inventors: Kevin D. Nelson, Brent B. Crow, Nickolas B. Griffin, Jennifer Seifert, Paul R. Sood, Alpeshkumar P. Patel, Paul A. Hubbard
  • Patent number: 10351437
    Abstract: The present invention relates to a new method for producing a calcium sulphate hemihydrate with unique properties for use for therapeutic applications in the cosmetic or pharmaceutical industry. Calcium sulphate hemihydrate is a biocompatible and biodegradable inorganic substance and thus suitable as a carrier in pharmaceutical compositions, e.g. a controlled release composition, containing at least one pharmaceutically active ingredient.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: July 16, 2019
    Assignee: LIDDS AB
    Inventors: Niklas Axén, Stefan Gruden
  • Patent number: 10335515
    Abstract: An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: July 2, 2019
    Assignee: The University of Kansas
    Inventors: Michael Detamore, Emily Beck, Stevin Gehrke, Cory Berkland
  • Patent number: 10335419
    Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: July 2, 2019
    Assignee: Warsaw Orthopedic, Inc
    Inventors: David S. Scher, Benjamin T. Reves, Roger E. Harrington, Susan J. Drapeau, Jerbrena C. Jacobs
  • Patent number: 10336720
    Abstract: The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: July 2, 2019
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Zhiyuan Zhong, Yan Zou, Yaohua Wei, Fenghua Meng
  • Patent number: 10335370
    Abstract: The present disclosure provides a controlled release composition comprising a plurality of microparticles and a matrix, wherein: the plurality of microparticles comprises a first material; the matrix comprises a second material; and the melting temperature of the first material is higher than the melting temperature of the second material. Also provided are methods of making and using the same.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: July 2, 2019
    Inventors: Jianjian Xu, Shiliang Wang, Manzhi Ding
  • Patent number: 10322298
    Abstract: Devices and methods for brachytherapy treatment are disclosed. One aspect is a poly(methyl methacrylate) apparatus for brachytherapy treatment at the vaginal apex. Another aspect is a poly(methyl methacrylate) apparatus for brachytherapy treatment in the distal two-thirds of the vagina. Another aspect is a poly(methyl methacrylate) apparatus for brachytherapy treatment of cancers that are offset from the vaginal apex. Other aspects include methods for guiding needles for treatment of cancers at the vaginal apex, in the distal two-thirds of the vagina, and that are offset from the vaginal apex.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: June 18, 2019
    Assignee: Washington University
    Inventor: Perry W. Grigsby
  • Patent number: 10300171
    Abstract: A resorbable crosslinked form stable membrane containing a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material, wherein the elastic pretensed collagen material is collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve, the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: May 28, 2019
    Assignee: Geistlich Pharma AG
    Inventors: Niklaus Stiefel, Sergej Stenzel, Raphael Kaufmann
  • Patent number: 10293062
    Abstract: Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: May 21, 2019
    Assignee: Duke University
    Inventor: Christopher David Lascola