Errodable, Resorbable, Or Dissolving Patents (Class 424/426)
  • Patent number: 11760858
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: September 19, 2023
    Inventors: Scott Zawko, Christine Schmidt
  • Patent number: 11751857
    Abstract: A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 12, 2023
    Assignee: ACCESS CLOSURE, INC.
    Inventors: Andreas Mylonakis, Florencia Lim
  • Patent number: 11746141
    Abstract: The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: September 5, 2023
    Inventors: Alexandra Dietrich, Michael Myers
  • Patent number: 11684587
    Abstract: A method of treating, reducing or preventing bacterial infection in a wound, the method comprising: applying a film on the wound, the film including a biodegradable polymer with bacteriophages dispersed therein, wherein the polymer is a poly (ester amide urea).
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: June 27, 2023
    Assignee: PHAGELUX (CANADA) INC.
    Inventors: Nancy Tawil, Ramaz Katsarava, David Tugushi, Vakhtang Beridze
  • Patent number: 11679243
    Abstract: A single or multi layered device (hereinafter alternately referred to as a “capsule”) of non-digestible material encapsulating an ingestible drug solution capable of slow solution release of stable solubilized drugs in water, saline, a buffer or lipophilic acceptable carriers. Methods for preparing the same and for safe, nearly constant dispensing of drugs following capsule swallowing. A safe, controlled flow release mechanism for the capsule's drug to the gastric system is disclosed.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 20, 2023
    Inventors: David R. Elmaleh, Doron Weinfeld
  • Patent number: 11654213
    Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: May 23, 2023
    Inventors: Changcheng You, Quynh Pham, Danny Concagh
  • Patent number: 11602578
    Abstract: The present invention concerns a polyelectrolyte coating comprising at least one polycationic layer consisting of at least one polycation consisting of n repetitive units having the formula (1) and at least one polyanionic layer consisting of hyaluronic acid. The polyelectrolyte coating has a biocidal activity and the invention thus further refers to the use of said polyelectrolyte coating for producing a device, in particular a bacteriostatic medical device, more particularly an implantable device, comprising said polyelectrolyte coating, and a method for preparing said device and a kit.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: March 14, 2023
    Assignees: Université de Strasbourg, Institut National De La Sante Et De La Recherche Medicale (INSERM), Protip Medical
    Inventors: Philippe Lavalle, Pierre Schaaf, Nihal Engin Vrana, Angela Mutschler, Cynthia Calligaro, Lorène Tallet
  • Patent number: 11597750
    Abstract: The present invention is directed to a method for producing a condensed phase of a silk fusion protein, the method comprising the steps of preparing a solution of a silk fusion protein in an aqueous medium and concentrating the silk fusion protein in the aqueous medium, wherein the fusion protein is isolated from a recombinant production host and comprises a silk-like protein sequence and two separate non-silk terminal module sequences, such as cellulose binding modules, SpyCatcher domains, tenth type III module of Fibronectin, gamma-crystallin D, flanking the silk-like protein sequence; wherein the method is performed so that the silk fusion protein is not precipitated and subsequently dissolved to the aqueous medium. The present invention is also directed to using such fusion proteins as adhesives.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: March 7, 2023
    Assignee: Aalto University Foundation sr
    Inventors: Markus Linder, Pezhman Mohammadi, Sesilja Aranko
  • Patent number: 11596712
    Abstract: An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: March 7, 2023
    Inventors: Slobodan Vukicevic, Kuber T. Sampath, Lovorka Grgurevic, Charles Cohen, Hermann Oppermann
  • Patent number: 11596605
    Abstract: The present application provides a method of making a particle comprising (i) obtaining a first solution comprising a negatively charged polysaccharide; (ii) obtaining a second solution comprising a positively charged polysaccharide; and (iii) mixing the first solution and the second solution to obtain a suspension comprising the particle. The present application also provides a method of making a therapeutic particle, comprising: (i) obtaining a solution comprising a therapeutic protein; (ii) obtaining a first suspension comprising the particle comprising a negatively charged polysaccharide and a positively charged polysaccharide, and (iii) mixing the solution of the therapeutic protein and the first suspension to obtain a second suspension comprising the therapeutic particle. The present application also provides particles (e.g.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: March 7, 2023
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Joseph Loscalzo, Ying-Yi Zhang
  • Patent number: 11591351
    Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: February 28, 2023
    Inventors: Shinya Yano, Yuki Wakasugi, Yosuke Iwanaga
  • Patent number: 11571498
    Abstract: The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 7, 2023
    Assignee: Covidien LP
    Inventors: Terry Morgan, Beth Sersen, Daniel Schulz-Jander, Joseph Traina, Brian Graham, Carol Sullivan, Gerald Hodgkinson
  • Patent number: 11564894
    Abstract: A method of treating, reducing or preventing bacterial infection in a wound, the method comprising: applying a film on the wound, the film including a biodegradable polymer with bacteriophages dispersed therein, wherein the polymer is a poly (ester amide urea).
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: January 31, 2023
    Assignee: PHAGELUX (CANADA) INC.
    Inventors: Nancy Tawil, Ramaz Katsarava, David Tugushi, Vakhtang Beridze
  • Patent number: 11554196
    Abstract: A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 17, 2023
    Inventors: Ingo Heschel, Hans Leemhuis, Georg Duda, Aarón Xerach Herrera Martín, Ansgar Petersen
  • Patent number: 11541129
    Abstract: Disclosed herein are biomaterial implants, medical devices, or bioprostheses wherein a surface or part thereof is coated with a nanoreservoir comprising a hydrophilic polymer or copolymer backbone crosslinked to a second polymer comprising a hydrophilic backbone and one or more reactive moieties, wherein the nanoreservoir further comprises one or more bioactive molecules, therapeutic molecules, or drugs.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: January 3, 2023
    Inventors: Cécile Oury, Christine Jérôme, Christophe Detrembleur, Patrizio Lancellotti
  • Patent number: 11513039
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: November 29, 2022
    Assignee: Axogen Corporation
    Inventors: Curt Deister, Kasra Tajdaran
  • Patent number: 11504268
    Abstract: A disposable dressing forms a compartment around and above a wound site and a volatile antimicrobial compound is allowed to sublimate/evaporate into the compartment. A heating element is included in the dressing, with heat stimulating wound healing and simultaneously accelerating sublimation/evaporation of the antimicrobial compound.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: November 22, 2022
    Assignee: Ethicon, Inc.
    Inventors: Howard Scalzo, Xintian Ming, Leo B. Kriksunov
  • Patent number: 11497710
    Abstract: The present embodiments provide compositions, methods and kits for the treatment of ocular conditions or maladies affecting the back of the eye, e.g., the retina.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: November 15, 2022
    Assignee: CHIBI, INC.
    Inventors: Vernon G. Wong, Glenn T. Huang
  • Patent number: 11471492
    Abstract: The application provides biocompatible carriers comprising bone forming and/or cartilage forming cells and methods for making them. The application further provides pharmaceutical compositions comprising said ATMPs and method of treatments using said ATMPs. The application further relates to said ATMPS for use in the treatment of bone disorders, cartilage disorders and joint disorders. The current invention further relates to method of treatments of bone disorders, cartilage disorders and joint disorders.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: October 18, 2022
    Inventors: Veerle Bloemen, Johanna Bolander, Frank Luyten
  • Patent number: 11465325
    Abstract: A method for manufacturing a closure constructed to be inserted and securely retained in a neck of a product-retaining container includes intimately combining a plurality of coated particles (each comprising a cork material core and a first plastic material) with a second plastic material, and other optional constituents; heating the composition to form a melt; extruding or molding a closure precursor from the melt; and optionally cutting and/or finishing the closure precursor. A composition for use in manufacturing a closure includes a plurality of coated particles (each comprising a cork material core and a first plastic material) with a second plastic material, and one or more blowing agents. Methods for producing particulate material, cork composite material, and additional method for producing closures are also provided.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: October 11, 2022
    Inventors: Marc Anton Charles Thometschek, Olav Marcus Aagaard, Floriane Marie Gabrielle Morel, Niels René Roos Everaert, Charlotte Laetitia Jeanette Boutry, Christine Phi Phuong Duong
  • Patent number: 11452700
    Abstract: The present disclosure provides polymeric particles and scaffolds comprising a matrix and an anesthetic agent. In one embodiment, the matrix comprises a bioerodible polymer. The disclosure further relates to the use of the polymeric particles and scaffolds for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk. The disclosure also provides methods of fabricating and administering polymeric particles and scaffolds containing an anesthetic agent described herein.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: September 27, 2022
    Inventor: Eric Haas
  • Patent number: 11447532
    Abstract: The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: September 20, 2022
    Assignee: BOLT THREADS, INC.
    Inventors: David Breslauer, Joshua Kittleson, Loren Perelman, Lindsay Wray
  • Patent number: 11439494
    Abstract: Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 13, 2022
    Assignee: MicroVention, Inc.
    Inventors: Xinping Wu, Jodi Hong, Gregory M. Cruise
  • Patent number: 11439690
    Abstract: The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: September 13, 2022
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vinod Labhasetwar, Hayder H. Jaffer
  • Patent number: 11434469
    Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: September 6, 2022
    Assignee: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen
  • Patent number: 11426484
    Abstract: Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof. Methods for producing absorbable self-retaining sutures that have high tensile strengths and pronounced sheath-core structures wherein the sheath is harder than the core are also provided.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: August 30, 2022
    Assignee: Tepha, Inc.
    Inventors: Said Rizk, Simon F. Williams
  • Patent number: 11419824
    Abstract: The present invention relates to a drug delivery system, in particular for a controlled administration of one or more active pharmaceutical ingredients to a body, and further in particular for oral administration of one or more active pharmaceutical ingredients to a body. The system thereby comprises a base component soluble in body fluids and a separate first component soluble in body fluids. The first component thereby comprises a therapeutically effective amount of a first active pharmaceutical ingredient.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: August 23, 2022
    Assignees: Laxxon Medical AG, Exentis Knowledge GmbH
    Inventors: Achim Schneeberger, Klaus Kühne, Helmut Kerschbaumer, Srdan Vasic
  • Patent number: 11389560
    Abstract: This invention is related to a surgical suture production method that has been given electrical conductivity to the surgical suture. The surgical suture production method subjected to the invention comprises the steps of, dissolving a conductive or semi conductive polymer that is to be used as coating material in a solvent together with a dopant that increases electrical conductivity, immersing the surgical suture inside this solution and coating the suture, taking the suture out of the solution and obtaining an electrical conductive layer on the suture after the solution on it has evaporated.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: July 19, 2022
    Inventors: Yetkín Öztürk, Esra Alvero{hacek over (g)}lu Durucu
  • Patent number: 11357837
    Abstract: Implantable matrices and methods are provided. The matrices are configured to fit at or near a target tissue site, the matrices comprise biodegradable materials and ligands bound to the matrices and are configured to bind receptors and allow influx of cells into the implantable matrices, wherein the ratio of ligands to receptors is from about 1.5 to about 0.5.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: June 14, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Vanja Margareta King
  • Patent number: 11337792
    Abstract: One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: May 24, 2022
    Assignee: The General Hospital Corporation
    Inventors: William G. Austen, Jr., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
  • Patent number: 11339943
    Abstract: The invention relates to a lighting device for motor vehicles. Said lighting device comprises a primary hologram for providing a lighting function when the primary hologram is illuminated with illumination light. The illumination light is directed towards the primary hologram via a secondary hologram system which comprises a coupling-in hologram, a waveguide substrate and a coupling-out hologram.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: May 24, 2022
    Assignee: Carl Zeiss Jena GmbH
    Inventor: Petr Vojtisek
  • Patent number: 11331348
    Abstract: A method is provided for preparing an ECM material, including an ECM gel, from regenerative or regenerating tissue. ECM material prepared from regenerative or regenerating materials also is provided.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Chien-Wen Chen, Yadong Wang
  • Patent number: 11298262
    Abstract: An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: April 12, 2022
    Inventors: Malik Y. Kahook, Glenn Sussman, Craig Alan Cable, II
  • Patent number: 11285171
    Abstract: The present invention relates generally to suppositories that release nitric oxide, and methods of using the same. According to some embodiments of the present invention provided herein is a nitric oxide (NO) releasing suppository (e.g., vaginal suppositories) are described herein. Some embodiments are directed to compositions, kits, and/or methods for treating and/or preventing an infection (e.g., a viral infection). In some embodiments, a method of treating and/or preventing a viral infection in a subject in need thereof is provided.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: March 29, 2022
    Assignee: Novan, Inc.
    Inventor: Hussaini Syed Sha Qhattal
  • Patent number: 11278565
    Abstract: Disclosed is a composition for treating a joint disease or a connective tissue disease, a composition for cartilage regeneration, or a composition for treating an inflammatory disease, each of the compositions containing dextran, poloxamer or a mixture thereof. The composition stays in the joint or connective tissue for a long time due to the shock-absorbing effect, coating effect or anti-inflammation effect, relieves the shock, covers a damaged portion in a specific manner thereto, or reduces inflammation of an adhered portion. Thus, the composition may be useful for the treatment of the joint disease, the connective tissue disease, or for the cartilage regeneration.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 22, 2022
    Assignee: MEDICINE PARK CO., LTD.
    Inventors: Yoo Sin Park, Il Hoon Lee
  • Patent number: 11266624
    Abstract: The present invention includes a method and compositions for preventing primary or acquired resistance of epidermal growth factor receptors (EGFR) inhibitors in a cancer with deregulated EGFR comprising: identifying a subject suspected of needing treatment for primary or acquired resistance to epidermal growth factor receptor (EGFR) inhibitors of the cancer with deregulated EGFR; and providing the subject with a therapeutically effective amount of a chromosome region maintenance 1 (CRM1) inhibitor and an inhibitor of EGFR in an amount sufficient to reduce or eliminate the cancer.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: March 8, 2022
    Assignee: Texas Tech University System
    Inventor: Weimin Gao
  • Patent number: 11266608
    Abstract: A hydrogel delivery composition and method, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent. The degradable microcapsules include one or more of magnesium hydroxide (Mg(OH)2), bovine serum albumin (BSA), polyethylene glycol (PEG), and sucrose to improve release duration.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: March 8, 2022
    Inventor: Jennifer J. Kang-Mieler
  • Patent number: 11260148
    Abstract: The method of making an implant consists on coating of a supporting structure (1) with synthetic hydroxyapatite by immersing the supporting structure (1) in a suspension (3) and triggering of a cavitation in a portion of the suspension (3) being in contact with the supporting structure (1). The suspension (3) is formed by a liquid external phase, advantageously water, and internal phase, i.e. particles of synthetic hydroxyapatite having an average particle size not exceeding 100 nm and containing structural water in an amount from 2 to 6% by weight. The implant is coated with the above described hydroxyapatite subjected to cavitation and a thickness of 50 nm to 1000 nm, advantageously 50 nm to 300 nm.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: March 1, 2022
    Inventors: Wojciech Swięszkowski, Tadeusz Chudoba, Sylwia Kuśnieruk, Aleksandra Kędzierska, Bartosz Woźniak, Julia Rogowska-Tylman, Dariusz Smoleń, Elzbieta Pietrzykowska, Witold Lojkowski, Jacek Wojnarowicz, Aharon Gedanken, Janis Locs, Vita Zalite, Mara Pilmane, Ilze Salma
  • Patent number: 11246958
    Abstract: A sterile, ready-to-use, flowable haemostatic composition comprises a soluble haemostatic agent comprising a plurality of carriers and a plurality of fibrinogen binding peptides immobilised to the carrier; a biocompatible liquid; and particles of biocompatible cross-linked polysaccharide suitable for use in haemostasis and which are insoluble in the biocompatible liquid. Such compositions may be used for the control of bleeding, especially in surgical procedures.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: February 15, 2022
    Inventors: Renata Zbozien, John Benjamin Nichols
  • Patent number: 11241394
    Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: February 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Liangfang Zhang, Che-Ming Jack Hu, Ronnie H. Fang, Brian T. Luk, Kuei-Chun Wang, Shu Chien
  • Patent number: 11236301
    Abstract: Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen therebetween and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: February 1, 2022
    Assignee: The Regents of the University of California
    Inventors: Tejal Ashwin Desai, Crystal Nyitray, Ryan Chang
  • Patent number: 11235087
    Abstract: Described are ready-to-use injectable compositions comprising polymeric microspheres or microparticles of non-animal origin, a hydrogel comprising water and a cellulose-derivative gelling agent, and polysorbate 80. Further described are methods of using the ready-to-use injectable compositions for reparative or plastic surgery, esthetic dermatology, facial contouring, body contouring, and gingival augmentation.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: February 1, 2022
    Assignee: Galderma Holding SA
    Inventors: Peter Morgan, Lubica Macakova
  • Patent number: 11229604
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: January 25, 2022
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Meriadeg Thomas
  • Patent number: 11213564
    Abstract: A wound healing composition and method for treating acute and chronic wounds and skin conditions includes a wound healing composition or formulation including a mixture of buckwheat honey, methylglyoxal and bacitracin.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: January 4, 2022
    Inventor: Kenneth A Sabacinksi
  • Patent number: 11197905
    Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: December 14, 2021
    Assignee: TissueGen, Inc.
    Inventors: Jennifer Seifert, Paul R. Sood, Brent B. Crow, Kevin D. Nelson, Nickolas B. Griffin, Alpeshkumar P. Patel, Paul A. Hubbard
  • Patent number: 11191853
    Abstract: A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. A method can include implanting a bio-dissolvable marker for imaging into a patient.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: December 7, 2021
    Assignee: The Johns Hopkins University
    Inventors: Michael Lim, Henry Brem, Betty Tyler, Jason Liauw, Sheng-Fu Lo
  • Patent number: 11186681
    Abstract: The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: November 30, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark Schoenfisch, Lei Yang, Yuan Lu
  • Patent number: 11160905
    Abstract: A regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, including: a porous polymer matrix having interconnected pores; and non-hydrated calcium silicate particles; wherein: the polymer matrix is anhydrous; the non-hydrated calcium silicate particles have a d50granulometry, preferably ranging from 0.05 ?m to less than the average diameter size of the pores of the matrix; and the non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. Also, a method for preparing the connective tissue regenerative material and uses of the regenerative materials, such as in the dental field; especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: November 2, 2021
    Inventors: Fleur Beres, Gilles Richard, Arnaud Dessombz, Stéphane Simon, Juliane Isaac
  • Patent number: 11147747
    Abstract: Provided herein are compositions and kits including trichloroacetic acid, and methods of using the same for debridement during endodontic treatment.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: October 19, 2021
    Inventor: Terrell F. Pannkuk
  • Patent number: 11129925
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: September 28, 2021
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae