Errodable, Resorbable, Or Dissolving Patents (Class 424/426)
  • Patent number: 11065360
    Abstract: A medical hydrogel composition, a medical hydrogel, a preparation method therefore and an application thereof, and a medical hydrogel kit. The medical hydrogel composition comprises a first component and a second component; the first component comprises polylysine and polyethylene imine; the second component comprises one or more of 4-arm-polyethylene glycol-succinimidyl glutarate, 4-arm-polyethylene glycol-succinimidyl succinate, and 4-arm-polyethylene glycol-succinimidyl carbonate; the degree of polymerization of the polylysine is 20 or more. The medical hydrogel is formed by reacting the first component with the second component of the medical hydrogel composition. The medical hydrogel kit comprises the medical hydrogel composition and a buffer solution used for dissolving the components of the medical hydrogel composition. The medical hydrogel has a degree of swelling of ?10%-50%, and can be applied in narrow parts where cranial, spinal, and peripheral nerves are densely distributed.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: July 20, 2021
    Assignee: Medprin Regenerative Medical Technologies Co., Ltd.
    Inventors: Limin Lin, Yaya Yang, Cheng Ma, Kunxue Deng, Yuyu Yuan
  • Patent number: 11058804
    Abstract: Methods and devices are provided for promoting wound healing. In general, surgical staplers and staple components are provided having an effective amount of at least matrix metalloproteinase (MMP) inhibitor being effective to prevent MMP-mediated extracellular matrix degeneration during wound healing in tissue.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: July 13, 2021
    Assignee: Ethicon LLC
    Inventors: Tamara S. Widenhouse, Frederick E. Shelton, IV
  • Patent number: 10980921
    Abstract: A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: April 20, 2021
    Assignee: ORTHOMEDEX LLC
    Inventor: James A. Walls
  • Patent number: 10980882
    Abstract: A hydrogel delivery composition, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: April 20, 2021
    Inventor: Jennifer J. Kang-Mieler
  • Patent number: 10973856
    Abstract: Described our medical compositions and methods including a particulate extracellular matrix tissue in admixture with sugar. Such medical compositions, in dried forms, can demonstrate enhanced rehydration properties. Medical compositions and products as described herein find particular use in treating diseased and/or damaged tissue, such as wound repair. Related methods of manufacture and use are also described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 13, 2021
    Assignee: Cook Biotech Incorporated
    Inventors: Michelle Chutka, Michael C. Hiles
  • Patent number: 10966848
    Abstract: Medical devices and method for manufacturing medical devices are discloses. An example medical device may include a medical device body formed from one or more multi-melting point polymeric filaments. Each of the filaments may include a polymeric blend comprising a first block polymer and a second polymer. The polymeric blend may have a first melting point and a second melting point less than the first melting point. The medical device body may be heat set at a temperature within 10° C. of the second melting point.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: April 6, 2021
    Inventors: Gerald Fredrickson, Mark W. Boden, Emma Boutcher
  • Patent number: 10953139
    Abstract: A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resulting in much enhanced durability and fatigue resistance, while maintaining the effectiveness as a cardiovascular implant.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: March 23, 2021
    Assignee: Xeltis AG
    Inventors: Aurelie Serrero, Martijn Antonius Johannes Cox
  • Patent number: 10954250
    Abstract: The present invention relates to compounds of Formula I:
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: March 23, 2021
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
  • Patent number: 10945854
    Abstract: Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: March 16, 2021
    Assignee: HAPPE SPINE, LLC
    Inventors: Ryan K Roeder, Gabriel L Converse, Stephen M Smith
  • Patent number: 10933164
    Abstract: A method includes covering or contacting a portion of a parathyroid of a subject with a shield including extraembryonic tissue and/or a parathyroid protective injection. The covering occurs during a neck or reconstructive surgery of the subject.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: March 2, 2021
    Inventor: James Glenn Norman
  • Patent number: 10913923
    Abstract: The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: February 9, 2021
    Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
    Inventor: Lei Ye
  • Patent number: 10912832
    Abstract: Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at least 3 days. The hydrogel is selected from the group consisting of hyaluronan (HA) or a derivative of HA, collagen, gelatin, fibronectin, fibrinogen, alginate, chitosan, and a synthetic biocompatible polymer. The anti-PEG antibody and the hydrogel are present in the mixture in a ratio from about 1:1 (v/v) to 1:100 (v/v). At least two dosages of the PEGylated therapeutic, which may be the same or different, are administered to the subject, with each dosage being given at about 1 hour to about 1 week apart. Accordingly, a novel method of treating a subject having cancer or ischemia disease is also provided.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 9, 2021
    Inventors: Patrick C. H. Hsieh, Pei-Jung Wu, Steve Roffler, Bill Cheng
  • Patent number: 10905775
    Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: February 2, 2021
    Assignees: Celator Pharmaceuticals, Inc., The Trustees of Princeton University
    Inventors: Lawrence D. Mayer, Robert K. Prud'homme, Christine J. Allen, Walid S. Saad
  • Patent number: 10905792
    Abstract: An improved fibrinogen-based tissue sealing patch having a degradation time of less than two weeks is disclosed. The patch comprises a polyethylene glycol-caprolactone-lactide (PEG-CL-LA) triblock copolymer film in which the PEG-CL-LA units are preferably connected by urethane linkages and into a surface of which a fibrinogen-based sealant comprising less than 8 mg/cm2 fibrinogen and less than 10 IU/cm2 thrombin has been incorporated. In preferred embodiments, the polymer film comprises PEG having a molecular weight of between 3000 and 3500 and a CL:LA:PEG ratio of 34:2:1. Methods of production and use of the patch are also disclosed.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: February 2, 2021
    Inventors: Orgad Laub, Eran Cohen, Yotam Schwartz
  • Patent number: 10898432
    Abstract: Hormone formulations, dosage units including the hormone formulations, and methods of use relate to a controlled release formulation, which includes hormones, e.g., progesterone. Formulations and methods are for controlling the reproductive cycle and/or ovulation of a female mammal, for example, to promote ovulation in a female mammal or synchronizing the ovulation or heat/estrus of a group of female mammals. In addition, formulations are for increasing the likelihood that a female mammal becomes pregnant, for example, after insemination or embryo transference. In addition, formulations are for reducing the anestrous period in a female mammal.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: January 26, 2021
    Assignees: Proinvet Innovations S.A., Proinvet Innovations LLC
    Inventors: Juan Andrés Colman, Daniel Roberto Sammartino
  • Patent number: 10898441
    Abstract: The embodiments relate to a pharmaceutically effective composition comprising sustained release particles, each sustained release particle comprising a shell and a core, wherein the shell comprises a first material and a second material, the second material comprising a first biodegradable material, wherein the core is enclosed by the shell and the core comprises a drug, wherein the first material is distributed in a matrix of the first biodegradable material, wherein the first material is configured to create holes in the shell and comprises metallic particles, wherein the holes allow the drug to be released to the exterior of the shell through the holes, and wherein the drug comprises a targeting material or targeting molecule that binds to a certain organ, object or a specific site within a body of a human or an animal.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: January 26, 2021
    Inventor: Neil S. Davey
  • Patent number: 10898498
    Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: January 26, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David S. Scher, Benjamin T. Reves, Roger E. Harrington, Susan J. Drapeau, Jerbrena C. Jacobs
  • Patent number: 10888551
    Abstract: The present invention provides for a drug delivery system for anti-cancer compound and method of preparation thereof.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: January 12, 2021
    Inventors: Radhika Poojari, Dulal Panda, Rohit Srivastava
  • Patent number: 10874605
    Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 29, 2020
    Assignee: ALLERGAN, INC.
    Inventors: Thierry Nivaggioli, James Jane-Guo Shiah, Qing Lin
  • Patent number: 10869953
    Abstract: A method includes covering or contacting a portion of a recurrent laryngeal nerve of a subject with a shield including extraembryonic tissue. The covering occurs during a neck or reconstructive surgery of the subject.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: December 22, 2020
    Inventor: James Glenn Norman
  • Patent number: 10869956
    Abstract: An interventional catheter assembly comprising a catheter for insertion and guidance to a target site in a body lumen or a cavity and an operating head mounted in proximity to a distal end of the catheter and comprising a system for removing obstructive material from the target site is provided. In certain embodiments, the catheter assembly includes at least one aspiration port located proximal to the operating head that communicates with a first sealed lumen for withdrawing fluids and obstructive material from the target site. The catheter assembly may also include at least one liquid infusion port that communicates with a second sealed lumen for supplying fluid to a location in proximity to the target site. Kits including the interventional catheter assembly with an aspiration and/or infusion conduit are also provided.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: December 22, 2020
    Inventors: Casey Torrance, Kate Walsh, Jared Salstrom, Scott Youmans, Edward I. Wulfman
  • Patent number: 10850274
    Abstract: The disclosure provides for microfluidic devices comprising patterned hydrogels with embedded cells or microtissues.
    Type: Grant
    Filed: April 9, 2016
    Date of Patent: December 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Shyni Varghese, Aereas Aung, Han Liang Lim
  • Patent number: 10842604
    Abstract: A non-setting agent for positioning a surgical mesh prosthesis against a tissue defect during surgical hernia repair enables a surgeon to position the surgical mesh prosthesis at an optimal location against the tissue defect without pre-measuring suture location and pre-suturing. The surgical mesh prosthesis can be repositioned by removing and replacing, or by sliding, the mesh along the tissue defect without traumatizing the tissue. The positioning agent is provided with adhesion and lubricity characteristics providing an adhesion strength required to temporarily maintain the surgical mesh in place, otherwise unsupported, against tissue of a targeted tissue location, and providing a viscosity that permits removal and replacement, or slidable movement, of the surgical mesh along the tissue upon receipt of a non-gravitational external force applied to the surgical mesh so movement of the surgical mesh that is atraumatic to the tissue.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: November 24, 2020
    Inventors: Roger Labrecque, Stephanie Santos
  • Patent number: 10842810
    Abstract: The present invention concerns polymer particles made from poly(lactic-co-glycolic acid) (PLGA) polymer, poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) copolymer, or the mixture of same, combined with hyaluronic acid molecules or hyaluronic acid salts, and the method for preparing same. The present invention also concerns injectable pharmaceutical or cosmetic compositions comprising such polymer particles, the method for preparing such compositions, and the use thereof for medical purposes, in particular for the prevention and/or treatment of musculoskeletal diseases, diseases and traumatic conditions of the skin, oral disorders, vaginal mucosa dryness and urinary infections or cystitis, dryness of the eye membrane and eye infections, obesity, and the use of same to combat ageing of the skin and/or for repairing the dermal tissue (mesotherapy).
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 24, 2020
    Assignee: GENBIOTECH
    Inventors: Yannis Guillemin, Dominique Vacher, Thomas Perrier, Maud Gonnet, Jean-Noël Gouze
  • Patent number: 10814112
    Abstract: A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 27, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mark Thomas Fulmer, David A. Armbruster, Robert Frigg, Elliott A. Gruskin, Sean Hamilton Kerr
  • Patent number: 10806696
    Abstract: An improved medical implant device directed to, inter alia, (i) avoiding unwanted initial drug “burst” problems, (ii) providing a more level amount of drug delivery, (iii) reducing blood clotting, (iv) reducing the amount of drug material that remains in the implant device, and/or (v) novel materials for an implant device.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: October 20, 2020
    Inventor: Robert W. Adams
  • Patent number: 10806828
    Abstract: A method for reattaching a detached tissue to a hard tissue includes operation in which a suture anchor having a first stitch and a second stitch is provided, wherein the first stitch is divided into a first strand and a second strand, and the second stitch is divided into a third strand and a fourth strand. The suture anchor is fixed on a hard tissue. The first strand, the second strand, the third strand and the fourth strand pass through a detached tissue. A bioinductive patch is provided, wherein the bioinductive patch includes a patch body and a button. The first strand and the third strand pass through the patch body and a first suture hole of the button, and the second strand and the fourth strand pass through the patch body and a second suture hole of the button. The second strand and the third strand are knotted to form a first strand node, and the first strand node presses the bioinductive patch and the detached tissue tightly onto the hard tissue.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: October 20, 2020
    Inventor: Chia-Wei Lin
  • Patent number: 10792481
    Abstract: The invention pertains to implantable medical devices for controlled delivery of therapeutic agents. Some devices according to the invention have a titanium reservoir, and a porous titanium oxide based membrane to control the rate of release of the therapeutic agent. The reservoir contains a formulation of the active agent, and means to promote water uptake into the reservoir upon implantation. In some embodiments the means include a gas with a higher solubility in than air water.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 6, 2020
    Inventor: Wouter Erik Roorda
  • Patent number: 10792477
    Abstract: The present invention is an inflatable balloon which is enclosed by an expandable cover which becomes increasingly porous/permeable during expansion. The balloon is coated or enclosed with a matrix which contains a pharmaceutically active agent. During expansion of the balloon, the pharmaceutically active agent is released or extruded through the expandable cover into a body cavity such as an artery or vein. The present invention also provides for a method of treating a disease or condition by delivering the inflatable balloon to a particular body cavity.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: October 6, 2020
    Assignee: OrbusNeich Medical PTE. LTD.
    Inventors: Robert J. Cottone, Stephen Rowland
  • Patent number: 10772828
    Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: September 15, 2020
    Inventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
  • Patent number: 10765354
    Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: September 8, 2020
    Assignee: MediBeacon Inc.
    Inventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
  • Patent number: 10758502
    Abstract: A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed. In the preferred embodiment, the topical anesthetic is a local anesthetic such as lidocaine, most preferably lidocaine free-base in a gel, and the dosage of the local anesthetic is effective in the painful area or immediately adjacent areas, to ameliorate or eliminate the pain. High concentration of local anesthetic in solution in the carrier is used to drive rapid release and uptake of the drug. Relief is typically obtained for a period of several hours.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: September 1, 2020
    Assignee: Centrexion Therapeutics Corporation
    Inventors: James N. Campbell, Arthur F. Michaelis
  • Patent number: 10758572
    Abstract: The present invention relates to substantially homogenous populations of human retinal progenitor cells having the following positive surface markers: SSEA4, CD73, PTK7 and PSA-NCAM. The invention also relates to method for preparing such substantially homogeneous cell populations from human tissue using cell sorting techniques.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 1, 2020
    Assignee: The Schepens Eye Research Institute
    Inventors: Michael J. Young, Petr Y. Baranov
  • Patent number: 10745511
    Abstract: The present invention provides a method for preparing hydrophilic polymer foam. The method comprises a step of providing an isocyanate functionalized prepolymer (A) and a step of foaming and curing the prepolymer (A). The prepolymer (A) is prepared by reacting diisocyanate (A1) and polyether polyol (A2), wherein the diisocyanate (A1) is selected from any one and a combination of 1,4-butyl diisocyanate (BDI), lysine diisocyanate (LDI) and 1,5-pentyl diisocyanate (PDI); the polyether polyol (A2) is a copolymer of ethylene oxide (EO) and propylene oxide (PO) and/or butylene oxide (BO); the ethylene oxide has a weight percentage of about 50%-100% in the polyether polyol, and has an OH functionality degree of 3-6, a hydroxyl value of about 21 mg KOH/g-168 mg KOH/g and a number-average molecular weight of about 1000 g/mol to about 8000 g/mol; and NCO content in the prepolymer (A) is 1%-10%.
    Type: Grant
    Filed: February 3, 2018
    Date of Patent: August 18, 2020
    Inventors: Jianli Zhang, Qing Zhou
  • Patent number: 10702539
    Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: July 7, 2020
    Assignee: Allergan, Inc.
    Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
  • Patent number: 10688061
    Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 23, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Naren Vyavahare, Aditi Sinha
  • Patent number: 10682442
    Abstract: The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: June 16, 2020
    Inventors: David Puleo, Todd Milbrandt, James Zach Hilt, Paul Fisher, Vishwas Talwalkar
  • Patent number: 10667897
    Abstract: Synthetic polymeric vascular grafts that promote endothelial healing and methods of their preparation and use are provided.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: June 2, 2020
    Assignee: University of Washington
    Inventors: Buddy D. Ratner, Le Zhen, Felix Simonovsky, Jonathan Himmelfarb
  • Patent number: 10660842
    Abstract: The disclosure relates to a cosmetic composition for the temporary shaping of hair, containing a combination of an anionic acrylate polymer and an amphoteric polymer. The cosmetic composition provides an extremely good moisture resistance.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: May 26, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Julia Bibiane Lange, Anna Puls, Cyrielle Martinez, Bernd Richters
  • Patent number: 10653689
    Abstract: The invention relates to (among other things) a method comprising the steps of (a) administering to a patient a PARP-inhibiting amount of a PARP inhibitor; and (b) administering to the patient a topoisomerase I-inhibiting amount of a long-acting topoisomerase I inhibitor.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: May 19, 2020
    Assignee: Nektar Therapeutics
    Inventors: Ute Hoch, Nancy Marie Burns, Deborah H. Charych
  • Patent number: 10647093
    Abstract: Disclosed is a biodegradable sheet comprising at least one layer which is a direct contact layer, intended to successfully contact materials, such as liquids, while maintaining the mechanical properties of the sheet and to extend the biodegradable sheet shelf life. The direct contact layer may comprise a hydrophobic polymer selected from poly(epsilon-caprolactone) (PCL) polyhydroxybutyrate (PHB), Polydioxanone (PDO) polyglycolic acid (PGA), polybutylene succinate (PBS), polybutylene succinate adipate (PBSA), poly lactic acid (PLA), polybutylene adipate terphtalate (PBAT), polyhydroxyalkanoates (PHA), such as polyhydroxybutyrates (PHB), polyhydroxyvalerates (PHV), and polyhydroxybutyrate-hydroxyvalerate copolymers (PHBV) or any mixture thereof. The biodegradable sheet may further comprise surface treated nanoclay particles, PVOH grafted with a crosslinker and PBS or PBSA The biodegradable sheet may further include at least one metalized, biodegradable, laminate layer.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 12, 2020
    Assignee: Tipa Corp. Ltd.
    Inventors: Daphna Nissenbaum, Tal Neuman, Dori Pelled, Shai Garty, Nili Konieczny
  • Patent number: 10646572
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 12, 2020
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 10617512
    Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 14, 2020
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • Patent number: 10603412
    Abstract: Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 31, 2020
    Assignees: Versitech Limited, City University of Hong Kong
    Inventors: Hoi Man Karen Wong, Wai Kwok Kelvin Yeung, Man Chee Kenneth Cheung, Dip Kei Keith Luk, Kin On John Lam, Kim Ho Paul Chu
  • Patent number: 10596298
    Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. The second portion of cortical bone is shaved into shavings. The shavings are long thin strips subjected to freeze-drying. The freeze-dried shavings are ground and demineralized and then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 24, 2020
    Assignee: Vivex Biologics Group, Inc.
    Inventors: Edgar S. Maldonado, Silvia Daniela Gonzales
  • Patent number: 10596262
    Abstract: The present invention relates to biomedically useful compositions of C2-C3 linked polyethers of 1,6:2,3-dianhydrohexopyranose derivatives combined with effective amounts of one or more bioactive agents. In certain embodiments the C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivatives are aqueous insoluble. In certain other embodiments biomedically useful compositions have the physical form of microparticles, microspheres, tubes, rods, sheets, membranes, fibers and the like. In certain embodiments the bioactive agent is a protein.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: March 24, 2020
    Assignee: TRGel, LLC
    Inventor: Alexander A Gorkovenko
  • Patent number: 10590236
    Abstract: A process of forming a lactide copolymer includes forming a dimethylidene lactide molecule from an L-lactide molecule. The process also includes forming a functionalized lactide monomer from the dimethylidene lactide molecule. The process includes forming a mixture that includes the functionalized lactide monomer and a bisphenol A (BPA) monomer or a BPA-derived monomer. The process further includes polymerizing the mixture to form a lactide copolymer.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: March 17, 2020
    Assignee: International Business Machines Corporation
    Inventors: Brandon M. Kobilka, Joseph Kuczynski, Jacob T. Porter, Jason T. Wertz
  • Patent number: 10588734
    Abstract: A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a flexible deposited fiber network of varying density including a first and second set of set of electrospun fibers. The second set of electrospun fibers is coupled to the first. A first portion of the flexible deposited fiber network includes a higher density of fibers than a second portion of the flexible deposited fiber network, and the tensile strength of first portion is higher than that of the second portion. The scaffold is sufficiently flexible to facilitate application of scaffold to uneven surfaces of the tissue substrate, and enables movement of the scaffold by the tissue substrate. The first and second set of fibers are configured to degrade within three months after application, and each fiber of the deposited fiber network has a diameter of 1-1000 nanometers.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: March 17, 2020
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • Patent number: 10589451
    Abstract: Apparatus for producing a three dimensional nanofiber structure includes (1) at least two spaced electrodes; (2) a spinner adapted to rotate the at least two spaced electrodes; (3) a syringe assembly adapted to eject a polymer solution from a syringe of the syringe assembly towards the at least two spaced electrodes while the at least two spaced electrodes are rotated by the spinner; and (4) a power supply assembly for providing the two spaced electrodes at a first electric potential, and for providing the syringe at a second electric potential which is different from the first electric potential. A composition of matter may include (1) a least one layer of nanofibers in which a distribution of angles of fibers is “aligned;” and (2) at least one gel layer, wherein the at least one layer of microfibers and the at least one gel layer alternate to form a laminate.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 17, 2020
    Assignee: New York University
    Inventors: Nikita Grigoryev, Kalle Levon
  • Patent number: 10590414
    Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 17, 2020
    Inventors: Ke Zhang, Xueguang Lu