Abstract: A food supplement and process for feeding a companion animal such as a dog or cat a diet containing an effective amount of lutein to enhance immune response and improve the overall health of the animal is provided. Preferably, the diet includes from about 1 to about 50 mg/day of lutein (from about 2 to about 315 mg lutein/kg diet). Such a diet provides sufficient lutein to be absorbed by the animal and supplied by the blood and blood leukocytes and neutrophils in the animal.

Abstract: The subject invention concerns novel biopesticides and their use to control cockroaches, carpenter ants, and pharaoh ants. Specifically, highly virulent isolates of Beauveria bassiana in an agricultural composition, can be used to effectively control these pests. Exemplified are Beauveria bassiana No. 447, ATCC 20872, and Beauveria bassiana SP111, ATCC 74038. Also described are unique formulations which are highly effective for delivering biocontrol agents to target pests. By using these novel compositions, target pests can be controlled without the environmental and public safety hazards presented by chemical control agents.

Abstract: A feed composition for animals (livestock, poultry, fish or pet) which contains poly-&ggr;-glutamic acid (and/or degradated product thereof) and, a method for reducing body fat acumulation in animals which comprises feeding animals with a feed composition containing poly-&ggr;-glutamic acid.

Abstract: Disclosed are an assimilation accelerator which contains &bgr;-glucooligosaccharide as an active ingredient, a calcium-supplementing diet which contains &bgr;-glucooligosaccharide and a calcium material, and a method for accelerating calcium assimilation using the calcium assimilation accelerator.

Abstract: A chewable calcium composition and its associated method of manufacturing are disclosed. The chewable composition includes a lipid base and a micronized calcium salt substantially uniformly mixed with the lipid base such that the lipid base forms a continuous phase. The composition provides for a relatively large dose of calcium in a easy to take chocolate like, chewable form. The composition of the present invention is manufactured by providing the lipid base including a melting temperature. The lipid base is then heated to a temperature of approximately 120° F. such that the lipid base melts. After the lipid base melts, the micronized calcium salt is mixed with the lipid base to form a melted mixture such that the micronized calcium salt is substantially uniformly distributed in the melted lipid base.

Abstract: The present invention provides a novel polypeptide which has fish growth hormone-like activity and which can be widely used no matter what the species of fish is.

Abstract: Consumable products including seamless capsules having an outer shell made of a carbohydrate material in a glassy state and an inner core.

Abstract: The invention relates to stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%, processes for their preparation and their use as an additive to foodstuffs, cosmetics, pharmaceuticals and animal feedstuffs.

Abstract: Multi-vitamin and mineral supplements for administration to a pregnant woman during her first, second, and third trimesters of pregnancy comprising specific regimens of a pharmaceutically acceptable calcium compound, vitamin D, folic acid, vitamin B12, vitamin B6, and vitamin B1. The prenatal supplements are specifically tailored to maximize fetal development and maternal health during each trimester of pregnancy.

Abstract: The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster.

Abstract: A method and composition for treating swine to increase their resistance to pathogenic microorganisms are disclosed. Microbial infections may be prevented or reduced in swine populations by administration of immune lymphokines which have been produced by the splenic T cells of immunized swine. The process and compositions are particularly useful for the control of Salmonella in swine.

Abstract: A granular feed nutrient supplement is formed by pelletizing a mixture of minerals, vitamins and other nutrients along with a carrier such as cornmeal or the like and optionally a lubricant such as fat and/or a binder. The pellets are rolled to a desired size and combined with bulk feed. The size of the formed granules are maintained close to the average particle size of the bulk feed thereby ensuring that the granules remain suspended in the feed and do not separate. Preferably the density of the granules is close to (±30%) the density of the feed.

Abstract: Methods and compositions are provided for enhancing feed utilization efficiency in a ruminant animal by adding to the feed a sufficient amount of a nonionic surfactant to enhance the utilization of the feed by the animal. The methods and compositions result in enhanced weight gain and/or milk production by the animal. Preferred nonionic surfactants include polyoxyethylenesorbitan monooleate and polyoxyethylenesorbitan trioleate at a concentration range of from about 0.01 to 1% (w/w) of the dry weight of the feed. A digestion enhancing enzyme and lactic acid bacteria inoculum may also be added to the feed. The surfactant is added to the feed by spraying a dilute solution of the surfactant onto the feed, or by coating the surfactant onto a particulate carrier such as celite, diatomaceous earth or silica and adding the carrier to the feed.

Abstract: The present invention relates to improving the biological efficiency of utilization of protein in ruminant feeds by protection of such protein from substantial degradation in the rumen without markedly reducing the subsequent absorption of the amino acid constituents of the protein in the lower digestive tract. In one aspect of the invention this is achieved by mixing a protein containing material with a reducing carbohydrate and subjecting the mixture to heat, pressure and shear forces.

Abstract: Lysine and methionine which are limiting amino acids of dairy cows are administered to dairy cows to decrease the BUN value that has an adverse effect on the conception rate and to increase the blood glucose required to improve the energy balance, that alanine and glutamine are administered to dairy cows to increase the blood glucose and to improve the liver function, and that the use of these amino acids is effective for keeping good conditions of dairy cows, allowing earlier arrival of initial estrus without any stress, improving the mating conception rate and decreasing the non-conception rate.

Abstract: The present invention provides a method of arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing insoluble protein deposit burden by the administration of branched polycationic compounds and pharmaceutical compositions containing such branched polycationic compounds. The compounds used in the preferred method of the invention are branched dendritic polycations.

Abstract: A nutritional composition and method useful for treatment of inflammatory bowel diseases is disclosed, the composition comprising selected vitamins and mineral salts for oral administration to a subject having an inflammatory bowel disease. The composition comprises an excess of vitamin D and vitamin B12, contains vitamin C and iron in quantities promoting good absorption, contains water miscible forms of the fat soluble vitamins, and no phosphate or carbonate salts. Preferably, the iron is present as ferrous fumarate. And, preferably the composition is essentially free of magnesium.

Abstract: An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms and improving allograft survival rates comprising the use of omega-9 unsaturated fatty acids to alter the immune response associated with organ transplantation. It is administered optionally in conjunction with an immunomodulatory diet comprising arginine and its salts, or metabolic precursors of arginine, together with an immuno-suppressive treatment comprising the administration of cyclosporine or other immuno-suppressants and optionally, with or without a donor specific transfusion. An especially preferred source of the omega-9 unsaturated fatty acids is canola oil.

Abstract: Disclosed herein are compositions which are highly effective rodenticides. The compositions include a plurality of glass whiskers which rodents are naturally attracted to for purposes of nest building, or are otherwise induced to pick up in their mouths. Upon biting the whiskers for either transport or eating, the rodents oral mucosa becomes irritated, often to the extent that the rodents are unable to subsequently eat without excruciating pain. Hence, the rodents death by starvation is inevitable.

Abstract: A ready-to-use water dispersible pigment composition containing at least 5% by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and/or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetables carbon black in the form of bodies of an average size which is at the most 10 &mgr;m is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for coloring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.

Abstract: The present invention discloses a process for improving the efficiency of feed utilization and/or for promoting the growth of animals in which an animal is fed a diet which comprises a composition comprising feed substance and a ready for use phospholipase additive. Preferably said composition also comprises at least one phospholipid. Said compositions are used to improve fat digestibility and to promote growth of the animal. The phospholipid is preferably lecithin and the preferred phospholipase is a mammalian phospholipase A2. In a preferred embodiment the phospholipase is produced using recombinant DNA technology to express the enzyme in a suitable host such as a microorganism or a transgenic plant.

Abstract: A process for feeding an animal a diet which alters the function and morphology of the gastrointestinal tract (GIT), a large lymphoid organ in the animal and which improves glucose metabolism, satiety, and nutrient absorption. The process involves feeding a companion animal such as, for example, a dog or cat a diet of a pet food composition containing fermentable fibers which have an organic matter disappearance (OMD) of 15 to 60 percent when fermented by fecal bacteria for a 24 hour period, the fibers being present in amounts from about 1 to 11 weight percent of supplemental total dietary fiber. The animal is maintained on the diet for a sufficient period of time to allow the fermentable fibers to ferment in the GIT of the animal.

Abstract: A process for preparing animal fee blocks requiring minimum physical compression which consists of adding an aqueous feed mixture to dry or semi-moist nutritive ingredients and at least one alkaline earth metal oxide. The resulting non-pourable and non-pumpable mixture is then transferred to a receiver, such as a mold, and subjected to compression.

Abstract: The invention provides an improved chew toy for delivering nutrients to pets. More particularly, the invention comprises rawhide having a coating or baste comprising at least one nutriceutical substance. In one aspect of the invention, the nutriceutical substance is Echinacea purpurea. In another aspect of the invention, the nutriceutical substance is glucosamine HCL. In another aspect of the invention, the nutriceutical substance is Vitamin A. In another aspect of the invention, the nutriceutical substance is calcium.

Abstract: There is provided a method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals by administering an effective amount of an alpha-2 adrenergic receptor antagonist.

Abstract: Highly concentrated aqueous L-Tryptophan and/or L-Threonine salt solutions are used to supplement mixed feeds with L-Tryptophan and/or L-Threonine. They can be metered easily and accurately, can be produced in a highly concentrated form with a content of between 30 and 70% and are storage stable to a surprisingly high degree (slight tendency to crystallize, no chemical decomposition, no racemization) even over a relatively long period of at least three months when outside temperatures are low.

Abstract: A feed fortifier and enhancer for preruminant, bovine calves comprising animal plasma as well as other ingredients. The feed fortifier and enhancer may be mixed with any liquid feed to be fed to preruminant calves.

Abstract: A digestible pouch and method for aiding in the oral administration of substances suitable for ingestion, in particular medicinal agents, is disclosed. Specific embodiments of the invention include a pouch formed of an edible food stuff material that is pleasing to the recipient, wherein the pouch comprises an inner compartment area for housing the particular substance prior to oral administration. The inventive pouch is particularly useful in administering medications to common domestic animals and children to whom oral administration of such medications is often difficult.

Abstract: The present invention concerns a formulation for an oral veterinary composition containing a fluoroquinolone antimicrobial agent or a pharmaceutically acceptable salt thereof, and a method of treating a microbial infection in a ruminant. The present veterinary composition, when administered orally to a ruminating animal (e.g., a cow or a feedlot calf), allows the fluoroquinolone to be readily and extensively absorbed from the rumen into the circulating blood and provides an unexpectedly extended duration of therapeutic antimicrobial blood level.

Abstract: A feed additive that provides increased feed conversion ratio is prepared containing a physiologically acceptable carrier and one or more of five thermostable xylanases from Microtetraspora flexuosa, preferably strain ATCC 35864. The xylanases can tolerate heating for one minute in a water bath at 95.degree. C. without substantial loss of activity, and tolerate alkaline conditions in a pH range of 7.0-10.0. A feed for poultry or pigs contains the xylanases in a feed containing at least 20% by weight cereal. The five xylanases have the following characteristics: (i) a molecular weight of about 33,100 daltons, a pI of about 8.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 70.degree. C.; (ii) a molecular weight of about 33,300 daltons, a pI of about 7.5, and a maximum activity at pH 7.0-7.5 at a temperature of about 65.degree. C.; (iii) a molecular weight of about 31,000 daltons, a pI of about 6.2, and a maximum activity at pH 7.5 at a temperature of about 65.degree. C.

Abstract: A stable crystalline powdery saccharide having a crystallinity of 40% or more, less hygroscopicity, satisfactory fluidity, and beneficial handleability, which is obtainable from an aqueous solution, containing trehalose and a different saccharide(s) crystallizable in the presence of trehalose, by crystallizing the trehalose along with the different saccharide(s).

Abstract: An animal feed composition for reducing colonization of animal intestines by Salmonella and other bacterial pathogens, includes a polysaccharide containing cis-hydroxy sugar units or a derivative thereof, or the monosaccharide ribose or rhamnose, or a derivative thereof, and an animal feed. The polysaccharide cis-hydroxy sugar units may be one or more of mannose, a mannose derivative, galactose, a galactose derivative, galactomannans, galactosamine, fucose and arabinose. The polysaccharides may be incorporated into an animal feed in the form of a food gum or other biolpolymer.

Abstract: The invention provides a purified phytate enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in animal feed.

Abstract: The invention relates to improved methods of raising and treating food animals, which employ pH-buffered, redox-stabilized compositions comprising halide and oxyhalide ions. The compositions can be administered to food animals to effect enhanced food utilization, lower mortality, decreased nitrogen excretion, decreased dependence on antibiotics and vaccines, overall enhanced health and immunostimulation in the animals.

Abstract: A process for removing nitrogenous wastes from animals with hepatic disease is provided and includes the steps of feeding an animal a diet consisting essentially of a pet food composition containing fermentable fibers which have an organic matter disappearance of from about 15 to about 60 percent when fermented by fecal bacteria for a 24 hour period, said fibers being present in amounts from about 1 to about 11 percent by weight of supplemental total dietary fiber, and maintaining the animal on that diet for a sufficient period of time to allow the fermentable fibers to ferment in the colon of the animal to enhance bacterial activity and provide an acidic environment in said colon for trapping the nitrogenous wastes for excretion through the feces of the animal.

Abstract: Disclosed is a flavonol-containing dry composition suitable for human consumption, together with uses thereof.

Abstract: A cDNA corresponding to the chicken interferon-.gamma. (IFN-.gamma.) gene has been isolated. The invention thus provides avian IFN-.gamma. polypeptides, nucleic acids encoding them, and their recombinant production. The nucleic acids and polypeptides are useful as therapeutic agents and as adjuvants for the treatment of birds.

Abstract: The present invention provides a method to prevent, inhibit, or reduce dental calculus deposits or formation on the teeth of a dental calculus forming animal comprising exposing the teeth to a food product comprising an acidulent amount of phosphoric acid, wherein said food product further comprises an amount of a polycarboxylic acid sequestering agent effective to prevent, inhibit, or reduce dental calculus deposits or formation. The present invention further provides the food products and the method of preparing the food products of said method.

Abstract: The use of conjugated linoleic acid to inhibit cyclooxygenase-catalyzed conversion of arachidonic acid, thromboxane formation and platelet aggregation.

Abstract: This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient durability to allow for a chewing cycle long enough for the release of the aforementioned cationic substances into saliva. Furthermore, the inventive animal chews may contain an effective amount of a counter-ionic compound, such as an alkali metal salt, to allow for rapid solubilization of said cationic antimicrobial substance into the saliva of an animal chewing thereupon, especially when delivered or carried on a carrier having a negatively charged surface.

Abstract: A dietary inclusion model for an integrated aquaculture-hydroponics system is derived from the concept of mass conservation. The model enables the maintenance of near-equilibrium concentrations of Ca, K, Mg, N, and P, suitable concentrations of Mn and Cu, and acceptable accumulation rates of Na and Zn, in representative integrated aquaculture-hydroponics systems, by modifying the mineral concentrations of the fish diets according to the model. The model is readily applicable to virtually any freshwater recirculating fish culture system operating at a recycle ratio sufficiently high to maintain appropriate nitrogen concentrations and having an environment suitable for hydroponic plant culture.

Abstract: The invention relates to a method of treating the navicular disease in horses, which comprises treating the navicular disease in horses with an effective amount of at least one compound of formula (I), ##STR1## wherein R.sub.1 is hydrogen, hydroxy, amino or halogen, and R.sub.2 is hydrogen, halogen or a radical which is bound through C, N, S or O, or of a C.sub.1 -C.sub.4 tetraalkyl ester thereof, each in the free form or in the form of the salt and/or in the hydrate form; to a compound of formula (I) for use in a method of treating the navicular disease, to a composition for use in a method of treating the navicular disease, which comprises one or more than one compound of formula (I), as well as to the use of a compound of formula (I) for the preparation of a veterinary composition for treating the navicular disease.

Abstract: A method for treating a human having elevated tumor necrosis factor levels by administrating an effective amount of one of the amino acids glycine, alanine, or serine.

Abstract: The process for preparing a product containing a healthful component according to the present invention is capable of providing a product containing a healthful component comprising at least one member of the group consisting of liver function improving constituents, cardiac function improving constituents, anti-inflammatory constituents antifat constituents, antioxidation constituents, and antimutagen constituents; and applied products containing the plain product as an ingredient, for example, foods which can be ingested in a large amount, livestock feeds and aquacultural feeds, cosmetics, diets of pets, and precursory products for pharmaceutical preparations. The process is capable of simply preparing the above-mentioned product in a large amount at a low cost. Heretofore, such products as the product of the present invention have not been provided at all.

Abstract: The composition of one or more selected soluble sugars and one or more selected dicarboxylic acids into a feed supplement for ruminant animals that maintains the appropriate level of lactic acid and pH of the rumen, and optimizes the availability of energy and nutrients for milk production or growth. The composition also includes one or more selected mineral salts and/or fat, fiber or flavor freshener.

Abstract: A bolus for delivery of pulsed doses of biologically active material to a ruminant comprises a series of distinct and separate bolus elements. Each bolus element is constructed of a degradable outer sheath and a core of biologically active material. The elements are adapted to separate following administration to the ruminant, and to disperse in the rumeno-reticular sac. In due course the elements degrade or corrode to release the biologically active material. Example boli include bolus elements of different respective corrosion characteristics and, as such, are capable of releasing pulsed doses of the active material to the ruminant.

Abstract: A powdered carrier formulation for delivery of phenylbutazone to animals contains phenylbutazone in combination with a flavoring agent and an anticaking agent.

Abstract: An animal feed containing a carboxylic acid either as the sole active ingredient or in combination with 1.alpha.-hydroxylated vitamin D compounds and/or phytase. The carboxylic acid or the combination of carboxylic acid with vitamin D compounds and/or phytase causes improved utilization of phosphorus, calcium, potassium, magnesium, zinc, iron and manganese in animal feed so as to minimize, or perhaps eliminate, the need for supplemental quantities of these minerals in an animal diet. In addition, low phosphorus containing animal feeds reduce the polluting effects on the environment since less phosphorus is excreted in the animal's feces which are then spread on agricultural land.

Abstract: The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in ruminant animals. The method includes mixing ingredients that include 190 proof ethanol in a concentration of about 9% by weight of a food supplement with clay and a nitrogen source such as urea to form the food supplement. The food supplement for ruminant animals additionally includes a condensed distiller's soluble fraction. The mixed ingredients are added to an animal feed such as corn. The animal feed and supplement are fed to an animal at least one per day.

Abstract: The present invention discloses a process for improving the efficiency of feed utilization and/or for promoting the growth of animals in which an animal is fed a diet which comprises a composition comprising feed substance and a ready for use phospholipase additive. Preferably said composition also comprises at least one phospholipid. Said compositions are used to improve fat digestibility and to promote growth of the animal. The phospholipid is preferably lecithin and the preferred phospholipase is a mammalian phospholipase A2. In a preferred embodiment the phospholipase is produced using recombinant DNA technology to express the enzyme in a suitable host such as a microorganism or a transgenic plant.