Abstract: Described herein is a nutritional supplement to be incorporated into the diet of a type 2 diabetic or an individual having lipodystrophy. The supplement provides active food-grade ingredients to improve the management of blood glucose and blood lipid levels. The supplement additionally aids in the improvement of the effects of platelet aggregation. The supplement should be taken daily during or at the end of the two largest meals, where most of the fat and cholesterol are likely to be ingested.

Abstract: The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.

Abstract: The present invention provides phytases having low Km values for phytic acid, a process for producing the phytases by using a microorganism having the ability to produce and accumulate the phytases and feed containing the phytases.

Abstract: A dry composition of an ionophore antibiotic such as monensin comprising from 10 to 95% (when expressed as the sodium salt) of at least one crystalline ionophore antibiotic, from 0 to 10% antifoam agent(s), from 0.

Abstract: A formulation for preventing or treating parturient hypocalcemia or milk fever comprises a solution of hydrochloric acid in water, soybean meal, additional feed components and minerals. The feed formulation is prepared by grinding soybean meal to a particle size of 1000 to 2000 microns. A hydrochloric acid solution and feedgrade limestone are blended into the meal to produce the formulation.

Abstract: An object of the present invention is to provide a bactericide (and a fungicide) that is highly safe and has strong bactericidal power even when used in low concentration, and that can be used repeatedly in a sterilizing process. The object can be achieved by the bactericide (or the fungicide) comprising a polar solvent extract of leaves of eucalyptus plants and chitosan. The polar solvent is preferably chosen from the group consisting of lower alcohols and glycols.

Abstract: A leather hydrolysate metal proteinate to be used as a metal nutrient for an animal feed. Chrome tanned leather scrap and shavings are heated in an aqueous solution with an alkali material to produce a water soluble, low molecular weight protein hydrolysate and insoluble chromium compounds which are subsequently separated from the hydrolysate. The hydrolysate is then oxidized to remove any objectionable trace organic residuals from the tanning process, and a di- or tri-valent water soluble metal salt is mixed with the hydrolysate to provide a metal proteinate. The metal proteinate, either as a liquid or a dried powder, can be used as animal or aquaculture diets.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: Seaweed supplement is included in diet of mammals and poultry to enhance immune response. In one embodiment, pasture forage is treated with seaweed supplement. When cattle or lambs are grazed on seaweed supplement treated endophyte-infected forage, immune function is preserved or depressed immune function is reversed. The enhanced immune function continues to the feedlot finishing phase even though no seaweed supplement is fed in that phase. In an independently inventive embodiment, seaweed supplement is administered to pigs exposed to PRRS disease to impart resistance to said disease and improve performance. In still another independently inventive embodiment, seaweed supplement is administered to lactating mares prior to weaning to mitigate the stress of weaning.

Abstract: A feedstock for feeding to animals is disclosed. The feedstock contains a mixture of feed for animals and shredded tires. Also disclosed is a method of using the feedstock to improve digestive efficiency and control harmful and toxic plants.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: A composition and method for enhancing immune response and improving the overall health of canines is provided which includes feeding the canines a dietary composition containing an effective amount of garlic in an amount of from about 1 to 10 g/kg diet. The dietary composition, when fed to canines, provides antioxidant, anticancer, and immunomodulatory benefits. The canines are fed the composition containing an effective amount of garlic in a quantity and frequency appropriate for their nutritional needs resulting in an enhanced immune response by increased lymphocyte blastogenesis and improves the overall health of the animal.

Abstract: Drug or foods and drink for prevention or treatment of diseases caused by abnormalities in cartilage tissues in which said drugs or foods and drinks have omega-9 unsaturated fatty acid as an active ingredient.

Abstract: An amino acid and/or a peptide are orally administrated to a neonatal ruminant whose fermenting function of the rumen has not yet developed thereby effecting a significant increase in the accumulation of fat between the muscle fibers as well as increase of the fattening effect during the fattening period.

Abstract: Hyaluronic acid, hyaluronate esters and salts thereof are sulfated such that the number of sulfate groups per monomeric unit is in the range of from 0.5 to 3.5. The sulfated derivatives exhibit anticoagulant and cell adhesion reduction properties, and may be used to prepare biomaterials.

Abstract: Seaweed supplement is included in diet of mammals and poultry to enhance immune response. In one embodiment, pasture forage is treated with seaweed supplement. When cattle or lambs are grazed on seaweed supplement treated endophyte-infected forage, immune function is preserved or depressed immune function is reversed. The enhanced immune function continues to the feedlot finishing phase even though no seaweed supplement is fed in that phase. In an independently inventive embodiment, seaweed supplement is administered to pigs exposed to PRRS disease to impart resistance to said disease and improve performance. In still another independently inventive embodiment, seaweed supplement is administered to lactating mares prior to weaning to mitigate the stress of weaning.

Abstract: A process uses extrusion technology for the production of a dense amino acid feed supplement. The feed supplement comprises of one or more substantially pure amino acids preferably selected from a group of lysine, threonine or tryptophan, alone or in combination. In one embodiment, a substantially pure amino acid is mixed with water to provide an extrudable mixture with a desired moisture content. The extrudable mixture is fed into an extruder and extruded through a die to provide at least one noodle of dense cohesive material. In another embodiment, at least one noodle is segmented, dried, milled and sieved to provide granules with a particle size range of between about 177 micron and 1190 micron. In a further embodiment, two substantially pure amino acids are mixed to provide a mixture which is extruded to produce at least one noodle.

Abstract: The phytase is preferably isolated from Monascus anka IFO 30873. The phytase has a Km of 20 &mgr;m when phytic acid is used as a substrate, the optimum pH is 6.0, the optimum temperature is 50° C., the molecular weight of the phytase is 120 kDa when measured by gel filtration, and the isolectric point is 4.8 using chromatofocusing.

Abstract: A process is provided for promoting bone modeling and chondrocyte functioning in growing canines. The process includes administering to a growing canine a pet food composition which includes an appropriate amount and ratio of dietary n-6 and n-3 fatty acids. The composition can further include a source of protein, a source of fat, a source of fiber, and a source of carbohydrates. Use of the preferred concentrations of n-6 and n-3 fatty acids can promote synthesis and tissue accumulation of down regulating elements of inflamation, which stimulate bone formation and optimize bone modeling.

Abstract: The present invention relates to a composition containing a &dgr;-aminolevulinic acid as effective dose for prevention and treatment of infection by pathogenic microorganisms and parasite. More particularly, it refers to the composition for prevention and treatment through cultivation of fish in a water tank containing &dgr;-aminolevulinic acid or the oral administration of a feed mixed with &dgr;-aminolevulinic acid to fish.

Abstract: An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tissue homogenate (at pH 5.0 or less) with test compound to determine if altered protein in the homogenate is cleared. The homogenate may be brain homogenate from a transgenic mouse infected with human prions. Compounds which are found to clear the altered protein are useful in preventing, arresting and/or reversing (i.e. treating) a disease associated with the conformationally altered protein.

Abstract: A pet food composition and method is provided for reducing inflammatory response in cats. The method includes administering a pet food composition including omega-6 and omega-3 fatty acids in a weight ratio of about 5:1, where the majority of omega-3 fatty acids comprise alpha-linolenic acid. Flaxseed oil is the preferred source of alpha-linolenic acid.

Abstract: A feed withdrawal composition is described which includes at least 70% by weight of a low D.E. starch hydrolysate. Due to the high solubility and digestibility characteristics of the composition, the composition may be fed to the animal up to 1-2 hours prior to slaughter. The composition results in (1) improvement in live weight at slaughter; (2) increased product yield and/or quality; and (3) reduced risk of carcass contamination in comparison to conventional programs of total feed withdrawal prior to slaughter.

Abstract: This invention provides an antibody capable of specifically inhibiting the fusion of an HIV-1 envelope glycoprotein cell with an appropriate CD4+ cell without cross reacting with the HIV-1 envelope glycoprotein or CD4 and capable of inhibiting infection by one or more strains so HIV-1. This antibody is then used to identify a molecule which is important for HIV infection. Different uses of the antibody and the molecule are described.

Abstract: This invention relates to a composition comprising benzoic acid or a derivative of benzoic acid capable of giving rise to free benzoic acid in vivo for use as a medicament for animals, wherein said acid/salt functions as an antibiotic, promotes growth, decreases feed conversion and improves digestibility of amino acids administered in animal feeds.

Abstract: Disclosed herein are compositions to meet the needs of aged pets and other animals. Pet foods, pet treats and pet supplements with anti-aging effects are disclosed whose compositions include the R-&agr;-lipoic acid in the amount of 0.10 grams to 1.5 grams and L-carnitine in the amount of 0.10 grams to 3 grams in addition to the usual composition. Optionally, coenzyme Q can be added in an amount of at least 1 mg/day. Optionally, creatine can be added in an amount of at least 0.2 grams/day. These additional components fight age-related declines in mitochondrial function, which result in less energy and other signs of aging.

Abstract: A formulation suitable for oral treatment with a medicament comprising:

Abstract: Herein is disclosed an aqueous stable lysine solution containing an acid radical in such amount that the solubility of lysine therein has been increased than in the corresponding aqueous lysine base solution, whereby during storage of lysine in the form of a free-lysine solution (liquid composition), the precipitation of lysine base crystals due to the drop in temperature is prevented thereby improving the handling thereof during transportation (transfer) etc.

Abstract: A feed additive for ruminants, comprising dried glutamic acid fermentation solubles, dried corn fermentation solubles, or a mixture of dried glutamic acid fermentation solubles and dried corn fermentation solubles, wherein said dried solubles have been dried to a total moisture content of less than 30% by weight at a temperature not less than about 80° F. and not more than about 900° F.

Abstract: Seaweed supplement is included in diet of mammals and poultry to enhance immune response. In one embodiment, pasture forage is treated with seaweed supplement. When cattle or lambs are grazed on seaweed supplement treated endophyte-infected forage, immune function is preserved or depressed immune function is reversed. The enhanced immune function continues to the feedlot finishing phase even though no seaweed supplement is fed in that phase. In an independently inventive embodiment, seaweed supplement is administered to pigs exposed to PRRS disease to impart resistance to said disease and improve performance. In still another independently inventive embodiment, seaweed supplement is administered to lactating mares prior to weaning to mitigate the stress of weaning.

Abstract: Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed.

Abstract: An oral hygienic compound and method for use in domesticated animals such as cats and dogs. The primary component of the oral hygienic compound is pure, natural garlic. The method involves coating or otherwise adulterating the animal's food with the oral hygienic compound in order to maximize garlic exposure within the oral cavity of the animal. Thus, the oral hygienic compound should promote chewing by the animal so as to evenly distribute the garlic within the animal's mouth. Garlic, in an uncooked state, has been found to substantially eliminate a pet's bad breath, whether by substantially reducing odor-causing bacteria within the oral cavity, and/or by other more systemic means when it is administered according to the inventive method.

Abstract: A process is provided for reducing adiposity in an animal such as a companion animal by feeding the animal an effective amount of Vitamin A for a time sufficient to reduce adiposity in the animal. Preferably, the such effective amount comprises from about 50,000 IU to about 1,000,000 IU of Vitamin A per kilogram of diet. Such an effective amount provides sufficient Vitamin A to decrease accumulation of body fat, increase UCP1 levels, and decrease serum leptin levels in the animal.

Abstract: The present invention concerns anti-stress agents for improving the resistance of aquatic animals and especially of fish, shrimps and invertebrates in fresh and sea water in the case of strains of all kinds, which can also be used as anti-stress agents for warm and cold water decorative fish, said agents containing a vitamin or a combination of vitamins in megadoses and one or more immune stimulators.

Abstract: Storage-stable, citrus-flavored compositions comprising citral or a citral derivative as the flavoring agent and a plant extract as the stabilizing agent. The plant extract inhibits the formation of p-methylacetophenone, thereby preventing the development of off-flavors and off odors, and increasing the shelf life of the composition.

Abstract: The invention relates to a composition, in pellet form, useful for the nutritional and/or medicinal supplementation of ruminants and a method for admixing the pellets with foodstuff. The pellet contains granules of one or more active ingredients/principles protected against degradation in toe rumen and one or more binding agents capable of being solubilized, crosslinked or melted. Optionally, the pellet may also contain an unprotected active ingredient for release in the rumen. The pellet may further contain a disintegrating agent and/or filler.

Abstract: Compositions comprising sesamol or a sesamol metabolite, such as pharmaceutical or therapeutic agents, dietary supplements and nutritional solutions, are described for use as anti-inflammatory agents. Methods for inhibiting inflammation are also described.

Abstract: Methods and compositions are provided for method of enhancing feed utilization efficiency in a ruminant animal by adding to the feed a sufficient amount of a nonionic surfactant to enhance the utilization of the feed by the animal. The methods and compositions result in enhanced weight gain and/or milk production by the animal. Preferred nonionic surfactants include polyoxyethylenesorbitan monooleate and polyoxyethylenesorbitan trioleate at a concentration range of from about 0.01 to 1% (w/w) of the dry weight of the feed.

Abstract: The present invention relates in general to a method of producing a dry, free-flowing mixture of liquid tocopherols. The present invention also relates to a dry free-flowing vitamin powder.

Abstract: Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:1 are desirable for a wide variety of nutritional, therapeutic and pharmacologic uses.

Abstract: An antiobestic agent of the present invention having antiobestic effect, carbohydrase inhibitory effect, blood sugar increase inhibitory effect, monosaccharide absorption inhibitory effect, cholic acid adsorptive excretion promoting effect, cholesterol lowering effect, blood triglyceride lowering effect and lipase inhibitory effect and being useful not only as an antiobestic agent but also as an antilipotrophic agent, an antihyperlipemic agent, an antiarteriosclerotic agent and an antidiabetic agent. Tamarind seed coat extract containing a large amount of procyanidin, which is a trimer represented by the following formula and serves as the active ingredient in the present invention, exhibits a potent antiobestic effect as such without the need for further purification.

Abstract: The present invention provides compositions comprising complexes of &bgr;-lactoglobulin with particular lipophilic nutrients, in particular vitamin E and vitamin K1. Preferably, bioselective absorption is employed to isolate &bgr;-Lg for use as a carrier protein. Also provided are food compositions and topical compositions comprising complexes of &bgr;-lactoglobulin and a lipophilic nutrient.

Abstract: A process is provided for limiting weight gain in cats. The process includes feeding the cat a pet food composition that includes a source of protein, a source of fat, and a source of carbohydrates from a grain source that excludes rice. Use of the preferred low glycemic index grain sources that comprise a blend of corn and sorghum; a blend of corn, sorghum, and barley; or a blend of corn, sorghum, and oats, has the effect of decreasing the postprandial blood glucose and insulin response of the cat as compared to when feeding a rice-based diet. The result is that the animal becomes satiated and voluntarily decreases its intake of food, causing less weight gain. This effect is even more marked when the composition is fed to male cats.

Abstract: A method is described for controlling or exterminating moles through the use of a bait composition in the form of a gel, paste, or grease. The composition includes an attractant and an active ingredient capable of killing vertebrate pests. The composition is injected into a mole tunnel through a small diameter nozzle, tube or needle to avoid digging open the tunnel or causing it to collapse.

Abstract: The present invention relates to a method for supplying bioavailable methionine to a cow which comprises supplying to the cow an ester of methionine or methionine amide and/or an ester of the hydroxy analogue of methionine or a salt thereof.

Abstract: A method of enriching fish food and live larval fish prey, especially Artemia nauplii and rotifers, with essentially highly unsaturated fatty acids, vitamins, amino acids, carotenoids and pigments. The live prey are allowed to ingest/adsorb dry soap powders of highly unsaturated fatty acids obtained from the waste stream of marine algae oil extraction. The live prey can be highly enriched in docosahexaenoic acid obtaining ratios of docosahexaenoic acid to eicosapentaenoic acid greater than about 2.0 to 1.0.

Abstract: Nutritionally balanced dog food compositions containing a dietary source of pyrophosphate, for reducing the incidence and extent of hip joint subluxation in dogs, and method of use. One embodiment of the dog food composition includes about 2.0% by weight sodium acid pyrophosphate. In use and in one embodiment of the method a puppy is fed the dog food composition as substantially the sole diet from weaning at about 6-8 weeks of age to about 2 years of age, to improve hip joint stability and reduce the incidence and severity of canine hip dysplasia.

Abstract: Carotenoid formulations comprising a mixture of &bgr;-carotene, lycopene and lutein, and the use thereof in human and animal foods, cosmetics and pharmaceuticals.

Abstract: Provided is an isolated phytase derived from a microorganism. The microorganism is preferably from the genus Monascus. The phytase has a Michaelis constant of 10 to 110 &mgr;M when phytic acid is used as a substrate. A process for producing the phytase also is provided, as is an animal feed comprising the phytase.

Abstract: A food supplement and process for feeding a companion animal such as a dog or cat a diet containing an effective amount of lutein to enhance immune response and improve the overall health of the animal is provided. Preferably, the diet includes from about 1 to about 50 mg/day of lutein (from about 2 to about 315 mg lutein/kg diet). Such a diet provides sufficient lutein to be absorbed by the animal and supplied by the blood and blood leukocytes and neutrophils in the animal.