Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
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Patent number: 10206872Abstract: A method of treating a patient in need of therapy with fentanyl or a salt thereof, the method comprising providing a ready-to-administer solution consisting essentially of fentanyl or a salt thereof as the sole active ingredient, a sugar or sugar alcohol and water for injection, the solution having a pH in the range of 3.5 to 7.5, and parenterally administering the solution to the patient.Type: GrantFiled: June 17, 2016Date of Patent: February 19, 2019Assignee: SUN PHARMACUETICAL INDUSTRIES LTD.Inventors: Samarth Kumar, Prashant Kane, Subhas Balaram Bhowmick, Milan Natvarbhai Thakkar, Kandarp Maheshkumar Dave
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Patent number: 10207022Abstract: A tissue dressing material for being applied in contact with a tissue of a patient. The tissue dressing material's main component is deacetylated native chitosan. Moreover, a liquid tissue dressing material for being applied in contact with a tissue of a patient, the tissue dressing material being an aqueous mixture. The main component of the constituent(s) of the mixture other than water is deacetylated native chitosan.Type: GrantFiled: September 1, 2009Date of Patent: February 19, 2019Assignee: MEDODERM GMBHInventors: Rivelino Montenegro, Thomas Freier
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Patent number: 10195187Abstract: Transdermal therapeutic system and method of using the same for safely treating hypocholinergic disorders of the central nervous system such as Alzheimer type dementia. The transdermal therapeutic system comprises oxybutynin in combination with a cholinergic receptor agonist (CRA) such as xanomeline.Type: GrantFiled: March 4, 2016Date of Patent: February 5, 2019Assignee: Chase Pharmaceuticals CorporationInventors: Thomas N. Chase, Kathleen E. Clarence-Smith
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Patent number: 10195242Abstract: The invention features therapeutic compounds useful for the treatment of skin diseases (e.g., psoriasis and eczema), infections (microbial, viral, and fungal), and wounds (e.g., cuts and burns). The compounds of the invention include therapeutically-effective amounts of L-Arginine, undecylenic acid, and Rheum Officinale extract. The invention further provides for the administration of the therapeutic compounds to a patient (e.g., a human) suffering from a skin disease, infection, or wound.Type: GrantFiled: January 27, 2014Date of Patent: February 5, 2019Assignee: Wintermute Biomedical, Inc.Inventors: Weston J. Hale, Thomas F. Rau
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Patent number: 10188858Abstract: Methods and systems for treating a tissue with a high frequency electric field to activate MAPK/ERK pathways, induce angiogenesis, induce angionenic factos such as NO and VEGF, or promote wound healing. Aspects of the invention are directed to methods of treating chronic wounds such as diabetic ulcers and hypoxia induced wounds. Aspects utilize high frequency electric field having a frequency in the GHz range, and preferably between about 1 GHz and about 10 GHz.Type: GrantFiled: September 18, 2014Date of Patent: January 29, 2019Assignee: University Of CincinnatiInventors: Daria Narmoneva, Andrei Kogan, Abdul Sheikh, Toloo Taghian
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Patent number: 10182900Abstract: An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.Type: GrantFiled: March 27, 2017Date of Patent: January 22, 2019Inventors: E. Aubrey Woodroof, Lipton Laverne Martin
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Patent number: 10179191Abstract: Compositions and methods for repair of tissue defects are disclosed. The compositions are prepared by entangling high molecular weight polycaprolactone polymer molecules with a polysaccharide such as hyaluronic acid by a dual solvent emulsion process to produce a porous flexible matrix which supports cell and tissue growth in vivo and ex vivo.Type: GrantFiled: October 9, 2014Date of Patent: January 15, 2019Assignee: Isto Technologies II, LLCInventors: Mitchell S. Seyedin, Anthony J. Ward
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Patent number: 10172980Abstract: The present invention is directed to a tissue separation barrier system for preventing the abnormal union of two or more tissues, as well as related methods of use. These tissue separation barrier systems offer the balance of strength and flexibility to allow the tissues, such as skin, to move in a smooth and natural manner while affording a barrier between two or more tissues. Furthermore, particular embodiments of the present invention include the methods of manufacturing the tissue separation barrier systems of the present invention.Type: GrantFiled: December 17, 2016Date of Patent: January 8, 2019Assignee: DME3D S.A.S.Inventors: David Enrique Jiménez Granada, Alejandro Gómez Rodríguez
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Patent number: 10166224Abstract: The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the disclosure teaches a condensation nicotine aerosol where nicotine meta-salicylate is vaporized. This disclosure relates to aerosol nicotine delivery devices. The delivery devices can be activated by actuation mechanisms to vaporize thin films comprising a nicotine meta-salicylate. More particularly, this disclosure relates to thin films of nicotine salt with meta salicylic acid for the treatment of nicotine craving and for effecting smoking cessation.Type: GrantFiled: August 7, 2017Date of Patent: January 1, 2019Assignee: ALEXZA PHARMACEUTICALS, INC.Inventors: Daniel J. Myers, James Cassella
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Patent number: 10154953Abstract: The present invention relates to the use of a composition comprising a peroxidic compound and a particular, generically defined copolymer for tooth bleaching.Type: GrantFiled: April 18, 2016Date of Patent: December 18, 2018Assignee: BASF SEInventors: Wolfgang Denuell, Adrian Natalello, Christian Schade, Dirk Mampe
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Patent number: 10154928Abstract: Methods and apparatuses are disclosed relating to the creation and use of bespoke wound fillers and other wound treatment apparatuses. Some embodiments provide for the creation of bespoke wound fillers based on characteristics of a wound. Certain embodiments also include the use of bespoke wound fillers in combination with negative pressure to treat a wound.Type: GrantFiled: August 8, 2013Date of Patent: December 18, 2018Assignee: Smith & Nephew PLCInventors: Edward Yerbury Hartwell, Mark Richardson, Carl Saxby
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Patent number: 10137062Abstract: The disclosure relates to methods of reducing static on hair or a cloth material, reducing hair frizz and/or increasing shine on hair by wiping the hair or cloth material with a dry wipe product. The dry wipe product comprises a flexible substrate having a first side and a second side; and either an anhydrous composition, or an aqueous composition, disposed over the first and/or second side(s) of the flexible substrate. When hair or cloth material is wiped with a side of the dry wipe product having the anhydrous composition or the aqueous composition disposed thereon, the anhydrous composition or aqueous composition is transferred from the flexible substrate of the dry wipe product to the hair or cloth material. The anhydrous compositions and aqueous compositions of the instant disclosure reduce static on hair and/or cloth, reduce hair frizz and/or increase shine on hair.Type: GrantFiled: November 30, 2012Date of Patent: November 27, 2018Assignee: L'OREALInventors: Michelle Salese, Jolene Morris, Chelsea Ali
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Patent number: 10117891Abstract: A combination of THC, CBD and Cobalamin (in a ratio of about 63%, 27% and 10%, respectively) is used with a topical carrier such as Shea butter cream to relieve pain. The THC and CBD mixture is extracted from a Cannabis Indica dominant strain using high pressure and carbon dioxide (CO2) as a solvent and comprises: Tetrahydrocannabinol “THC” (9-Tetrahydrocannabinol (delta-9 THC), 8-Tetrahydrocannabinol (Delta-8 THC) and 9-THC Acid), Cannabidiol “CBD”, Cannabinol “CBN”, Cannabichromene (“CBC”), Cannabigerol (“CBG”), terpenoids and flavonoids. The Shea butter is an extract from the Shea nut from the Shea tree (Vitellaria paradoxa).Type: GrantFiled: September 16, 2015Date of Patent: November 6, 2018Assignee: India Globalization Capital, Inc.Inventors: Ramachandra Mukunda, Ranga Chelva Krishna
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Patent number: 10105466Abstract: Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.Type: GrantFiled: April 21, 2014Date of Patent: October 23, 2018Assignee: KCI Licensing, Inc.Inventors: KZ Hong, Shannon C. Ingram, Dmitry Zimnitsky, Justin Alexander Long, Richard M. Kazala, Jr., Hugo Ramirez
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Patent number: 10105398Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.Type: GrantFiled: May 23, 2014Date of Patent: October 23, 2018Assignee: MiMedx Group, Inc.Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
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Patent number: 10086105Abstract: The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.Type: GrantFiled: September 8, 2015Date of Patent: October 2, 2018Assignee: Providence Health System—OregonInventors: Jian Xin Guo, Kenton W. Gregory
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Patent number: 10087401Abstract: Disclosed herein are water soluble compositions, such as films, including a mixture of a first water-soluble resin, an enzyme, and an enzyme stabilizer which comprises a functional substrate for the enzyme, methods of making such compositions, and methods of using such compositions, e.g. to make packets containing functional ingredients. The enzymes can include proteases and mixtures of proteases with other enzymes, and the compositions provide good retention of enzyme function following film processing and storage.Type: GrantFiled: March 16, 2012Date of Patent: October 2, 2018Assignee: MONOSOL, LLCInventors: David M. Lee, Jennifer L. Sims
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Patent number: 10086116Abstract: Adjunct material retained by a staple cartridge assembly is provided. The adjunct material provides elution of medicants therefrom such that release of one medicant regulates release of another medicant. A first medicant is released as a bolus dose substantially immediately upon delivery of the adjunct material to tissue. The second medicant is associated with the staple cartridge assembly in a manner such that release of the second medicant to tissue is regulated by the release of the first medicant.Type: GrantFiled: August 31, 2015Date of Patent: October 2, 2018Assignee: Ethicon LLCInventors: Michael J. Vendely, Chad E. Eckert, Frederick E. Shelton, IV, Jason L. Harris
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Patent number: 10081794Abstract: This invention relates a structure and system for growth factor incorporation which can improve the osteogenic differentiation of hMSCs, for potential bone regeneration and bone growth applications or used alone for bone repair or growth applications. The system comprises a biodegradable polyester, a hydrophilic polymer, a growth factor and optionally a bioceramic.Type: GrantFiled: April 13, 2012Date of Patent: September 25, 2018Assignee: New Jersey Institute of TechnologyInventors: Treena Lynne Arinzeh, Tamunotonye Briggs
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Patent number: 10071003Abstract: A disposable treatment article or disposable cleaning article that includes a hydrophobic nanoporous material. The disposable treatment or cleaning article is configured to contact and apply the nanoporous material to a surface. The nanoporous material is configured to form hydrophobic nanostructures on a surface upon the application of an activation stimulus. The nanostructures provide an anti-contamination benefit to the surface upon which the nanostructures are disposed.Type: GrantFiled: September 22, 2014Date of Patent: September 11, 2018Assignee: The Procter & Gamble CompanyInventors: Donald Carroll Roe, David S Salloum, Brandon Ellis Wise, Vladimir Gartstein, Faiz Fiesal Sherman
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Patent number: 10053681Abstract: The present disclosure relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.Type: GrantFiled: September 9, 2014Date of Patent: August 21, 2018Assignee: THE ROCKEFELLER UNIVERSITYInventors: Vincent A. Fischetti, Anu Daniel, Chad Euler
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Patent number: 10053686Abstract: The present invention relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. For easy processing and amplification of nucleic acid samples, the samples are bound to a solid support and used directly, without purification, in a nucleic acid amplification reaction such as the polymerase chain reaction (PCR).Type: GrantFiled: March 14, 2014Date of Patent: August 21, 2018Assignee: GE HEALTHCARE UK LIMITEDInventors: Michael Kenneth Kenrick, Aidan Mark Emery, Fiona Elizabeth Allan, Bonnie Lee Webster, Erik Leeming Kvam, Wei Gao
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Patent number: 10046085Abstract: Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.Type: GrantFiled: June 1, 2010Date of Patent: August 14, 2018Assignee: InCube Labs, LLCInventors: Mir Imran, Sanjay Patel, Joel Harris
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Patent number: 10047466Abstract: A method for fabricating a bandage comprises the following steps: preparing multiple complex yarns each comprising chitosan fibers and rayon fibers; (b) weaving solely the multiple complex yarns to form a preformed bandage; (c) immersing the preformed bandage in an acid alcohol, and then washing the preformed bandage by alcohol to obtain an alcohol-washed bandage; and, (d) heating the alcohol-washed bandage to obtain the bandage. The bandage related to the method is comprised of complex yarns, wherein each of the complex yarns is composed of chitosan fibers and rayon fibers. By means of immersing the preformed bandage into an acid alcohol, the bandage thus obtained has enhanced tensile strength, decreased dissolution rate and reduced hemolytic dose.Type: GrantFiled: November 20, 2013Date of Patent: August 14, 2018Inventors: Teeming Tsao, Juin-Hong Cherng, Cheng-Che Liu, Shou-Hung Tang
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Patent number: 10046150Abstract: A blood coagulating device can include an absorbent body; and a hemostatic lysine composition associated with the body. The body can have a cylindrical or conical member having a first end having the hemostatic composition, the first end being configured for insertion into a nasal passageway. A method for coagulating blood can include providing a powdered hemostatic lysine composition; and applying the powdered hemostatic lysine composition to blood so as to cause the blood to coagulate and form a clot. The coagulation can occur in a nasal passageway away from a blood vessel. The method can include providing at least one absorbent member having the powdered hemostatic lysine composition; and applying the at least one absorbent member to the blood so that the powdered hemostatic lysine composition causes the blood to coagulate and clot.Type: GrantFiled: September 6, 2017Date of Patent: August 14, 2018Assignee: Park City Bio, LLCInventors: Jonathan M. Benns, Matthew C. Lawyer
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Patent number: 10039862Abstract: A method for producing an antimicrobial coating on a surface. The method includes mixing a parylene dimer and an antimicrobial agent to form a mixture, heating the mixture to sublimate the parylene dimer and suspend the antimicrobial agent within the sublimated parylene dimer, pyrolyzing the sublimated parylene dimer to form a parylene monomer while the antimicrobial agent is suspended within the parylene monomer, and condensing the parylene monomer and the antimicrobial agent together on the surface to polymerize the parylene monomer and form a coating containing a parylene polymer and the antimicrobial agent.Type: GrantFiled: July 8, 2016Date of Patent: August 7, 2018Assignee: Cardiac Pacemakers, Inc.Inventors: Danielle Frankson, Mary M. Byron, Kurt G. Koubal
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Patent number: 10034615Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.Type: GrantFiled: February 17, 2015Date of Patent: July 31, 2018Assignee: NeuroNexus Technologies, Inc.Inventors: Jamille Farraye Hetke, Daryl R. Kipke, Rio J. Vetter
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Patent number: 10022910Abstract: The present invention provides an ancillary additive manufacturing system for manufacturing a reconstructed model simultaneously during the oral surgery to effectively reduce the time and healthcare human resources for the oral surgery. The ancillary additive manufacturing system comprises an input device and a printing body. The printing body is connected to the input device and comprises a base, an ink-manufacturing module, an inkjet head controlling unit, and multiple inkjet heads. The ink-manufacturing module is located above the base and comprises first, second, and third ink-manufacturing units. The inkjet head controlling unit is located above the base. The inkjet heads are mounted to the inkjet head controlling unit and point toward the base and comprise a first, second, and third inkjet head. The first, second, and third inkjet head correspondingly connected to the first, second, and third ink-manufacturing units.Type: GrantFiled: February 17, 2015Date of Patent: July 17, 2018Assignee: 3D Global Biotech Inc.Inventor: Keng-Liang Ou
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Patent number: 10022308Abstract: The present invention relates to methods and products, such as wet wipes and absorbent articles, that are capable of imparting a health benefit when used in the intended fashion. More specifically, the products described herein comprise one or more botanical compounds, which are capable of selectively controlling the balance of flora on the skin. The compounds may enhance the adherence of healthy flora to the surface of skin or mucosa, inhibit the growth of problem flora on or around the skin surface, or inhibit the adherence of problem flora to the surface of skin or mucosa, or any combination thereof.Type: GrantFiled: August 22, 2014Date of Patent: July 17, 2018Assignee: Kimberly-Clark Worldwide, Inc.Inventors: David William Koenig, Beth A. Lange, Christine L. Schneider
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Patent number: 10016345Abstract: Kit for whitening a body surface of a user, comprising: an oxidizing composition application device (12); wherein the kit comprises an activator sheet (14) which is movable independently of the oxidizing composition application device (12), the activator sheet (14) comprising an outer deformable substrate (50) intended to be applied on an oxidizing composition (34) placed on the skin of the user, the activator sheet (14) comprising an activator composition (52) carried by the outer substrate (50).Type: GrantFiled: July 15, 2014Date of Patent: July 10, 2018Assignee: L'OREALInventors: Gaurav Agarwal, Shoibal Pattanaik, Prasun Bandyopadhyay, Caroline Delaunay
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Patent number: 10016469Abstract: Disclosed is a method of treating vaginosis with a composition having Steroidobacter denitrificans YH1 (KCTC18345P) and Lactobacillus crispatus YH2 (KCTC18346P) strains, wherein the composition further includes at least one buffer selected from the group consisting of sodium phosphate monobasic, sodium phosphate dibasic, sodium phosphate tribasic, citric acid, sodium citrate, phosphoric acid, hydrochloric acid, sodium hydroxide, sodium pyrophosphate, and pyrophosphate.Type: GrantFiled: July 20, 2016Date of Patent: July 10, 2018Assignee: Two Lines Co., Ltd.Inventors: Chong hyun Jung, Nam Woong Yang
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Patent number: 10004586Abstract: Biocompatible tissue grafts are provided. The biocompatible tissue grafts include a bulk graft including a biocompatible material and having at least a first surface. The biocompatible tissue grafts also include a coating including a hydrogel and being immobilized on the bulk graft at the first surface. The biocompatible material includes at least one of a biologic material or a biologic-synthetic composite material. The hydrogel includes cross-linked hydroxyphenyl-substituted hyaluronan (HPS-HA), cross-linked hydroxyphenyl-substituted collagen (HPS-C), or both. The cross-linked HPS-HA, cross-linked HPS-C, or both have been formed by cross-linking of hydroxyphenyl groups of HPS-HA, HPS-C, or both to form dihydroxyphenyl bridges. Also disclosed are methods for repair of tissue damage in a subject in need thereof. The methods include surgically implanting the biocompatible tissue graft into a site of the tissue damage in the subject.Type: GrantFiled: August 27, 2015Date of Patent: June 26, 2018Assignee: The Cleveland Clinic FoundationInventors: Kathleen Anne Derwin, Anthony Calabro
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Patent number: 9994726Abstract: A laminate having high adhesion between a fine cellulose layer and a base material, a method for producing the same, and a gas barrier material. The laminate is such that a fine cellulose layer containing fine cellulose having a carboxyl group is laminated on the base material, and a mixed layer in which the fine cellulose is mixed in the base material is further interposed between the base material and the fine cellulose layer. This laminate can be produced by coating the base material with a dispersion containing fine cellulose having a carboxyl group, swelling the base material with the thus coated dispersion, and drying the swollen base material and the coated dispersion. The laminate may also be produced by providing a swollen base material, coating the swollen base material with a dispersion containing fine cellulose having a carboxyl group, and drying the base material and the coated dispersion.Type: GrantFiled: March 18, 2014Date of Patent: June 12, 2018Assignee: TOPPAN PRINTING CO., LTD.Inventors: Mitsuharu Kimura, Yumiko Oomori, Nao Nishijima, Kosuke Shimizu
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Patent number: 9980921Abstract: Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.Type: GrantFiled: June 27, 2017Date of Patent: May 29, 2018Assignee: TAHO PHARMACEUTICALS LTD.Inventors: Shen-Yung Kao, Taijung Wu, Catherine Lee
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Patent number: 9982393Abstract: This invention relates to the composition of a chitosan coated paper wherein the chitosan may be derived from a variety of sources. Methods of using chitosan as a surface coating or pulp additive to tune the properties of paper and paperboard products are also described. The chitosan applied is a bio-based and environmentally friendly barrier coating and/or additive material for the manufacture of functional paper and paperboard products, specifically as evaporative cooling media requiring wet strength and structural integrity, wicking, and moisture resistance as an alternative to conventional phenolic-based resins. The solid-state fermentation method to produce chitosan and its derivatives offer renewable bio-based materials towards the manufacture of functional paper products that are eco-friendly but also offer uncompromized performance levels.Type: GrantFiled: July 11, 2016Date of Patent: May 29, 2018Assignee: Western Michigan University Research FoundationInventors: Andro Hernandez Mondala, Brian Richard Young
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Patent number: 9980917Abstract: An abuse deterrent immediate release coated reservoir solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or prescribed units of the dosage form are orally administered but exhibits a reduced rate of release when more than the prescribed number of units, are administered.Type: GrantFiled: February 24, 2017Date of Patent: May 29, 2018Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala, Dilip Shanghvi
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Patent number: 9976974Abstract: Osmolarity-responsive hydrogel sensors, particularly biosensors, containing quaternary ammonium functionality, which are useful for, inter alia, continuous osmolarity monitoring with no pH interference, are disclosed. Methods of using the osmolarity-responsive hydrogels are also disclosed.Type: GrantFiled: January 26, 2016Date of Patent: May 22, 2018Assignee: University of Utah Research FoundationInventors: Tram Nguyen, Jules John Magda, Seung-Hei Cho, Prashant Tathireddy
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Patent number: 9949897Abstract: The present invention relates to a cosmetic process which applies onto the skin a self-standing cosmetic sheet for the skin, comprising: ?at least one biocompatible and/or biodegradable hydrophobic polymer layer ?wherein ?the self-standing cosmetic sheet has a thickness of from 10 to 1000 nm, preferably from 30 to 500 nm, and more preferably from 50 to 300 nm. The cosmetic sheet according to the present invention may comprise at least one cosmetic active ingredient. The cosmetic sheet used in the present invention is very thin and not easily perceived on the skin; can be prepared with a variety of materials such as a biocompatible and/or biodegradable material, preferably non-cross-linked poly(lactic acid) or a combination of chitosan and alginic acid; and can adhere well onto the skin without any adhesive layer so that it is less irritable or no irritable to the skin.Type: GrantFiled: April 11, 2012Date of Patent: April 24, 2018Assignee: L'OREALInventors: Toshifumi Shiroya, Anne Laure Bernard, Christophe Dumousseaux
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Patent number: 9931366Abstract: The present disclosure refers to topical pharmaceutical bases that include a synergistic combination of pracaxi oil, andiroba oil, copaiba balsam, and ucuuba butter. Further, these topical pharmaceutical bases are proposed for treating skin conditions in mammals, such as, for example wounds and scars. The topical pharmaceutical bases provide healing, moisturizing, anti-inflammatory, antibacterial, and antifungal effect. Additionally, the topical pharmaceutical bases enable an effective administration of specific active pharmaceutical ingredients (APIs), thereby improving treatment outcomes. Topical pharmaceutical compositions including the topical pharmaceutical bases increase the residence time of APIs within a wound or scar, thereby improving the penetration of APIs into the affected area. Also, the topical pharmaceutical bases provide relatively uniform distribution of the APIs within the topical pharmaceutical compositions.Type: GrantFiled: August 20, 2015Date of Patent: April 3, 2018Assignee: Professional Compounding Centers of AmericaInventor: Daniel Banov
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Patent number: 9913757Abstract: A dressing for an open wound includes a cover layer dimensioned for positioning relative to a wound bed. The cover layer permits an evacuation of the space around the wound bed such that a sub-atmospheric pressure may be established to stimulate healing and facilitate the removal of fluid from the wound. Multiple performance zones in the cover layer allow the wound dressing to remain in position through repeated cycles of evacuation without placing undue strain on the wound bed. An outer peripheral zone may include a high peal-strength adhesive while an intermediate zone may include a shear resistant adhesive. A central zone may be devoid of any coating to maximize moisture transmission through cover layer.Type: GrantFiled: October 29, 2015Date of Patent: March 13, 2018Assignee: Smith & Nephew, Inc.Inventor: Ronald F. Vitaris
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Patent number: 9895847Abstract: A contact coating device comprising a high viscosity rapid deposition head comprising a deposition body defining a material supply passage; a dispensing/shaping nozzle being formed adjacent in a leading end surface of the high viscosity rapid deposition head for dispensing of the high viscosity material from the high viscosity rapid deposition head, and the dispensing/shaping nozzle comprising a dispensing cavity; at least one dispensing passage providing communication between the material supply passage and the dispensing/shaping nozzle for suppling the high viscosity material to the dispensing cavity; and a heating element for heating a portion of the high viscosity rapid deposition and facilitating flow of the high viscosity material through the high viscosity rapid deposition head. A multi-head material deposition system which comprises a first drop-on-demand device, a second drop-on-demand device and at least one contact coating rapid deposition head is also disclosed.Type: GrantFiled: November 26, 2014Date of Patent: February 20, 2018Assignee: Solidscape, Inc.Inventors: Bun Chay Te, John Theodore Wigand
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Patent number: 9889154Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.Type: GrantFiled: January 14, 2016Date of Patent: February 13, 2018Assignee: Z-MEDICA, LLCInventors: Giacomo Basadonna, Brent A. Johnson
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Patent number: 9867905Abstract: Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices for differentiating stem cells and progenitor cells, and for producing and isolating blood vessels and vascularized graft constructs are described.Type: GrantFiled: December 10, 2008Date of Patent: January 16, 2018Assignees: PURDUE RESEARCH FOUNDATION, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Sherry L. Voytik-Harbin, Seth Kreger, Mervin C. Yoder, Paul Critser
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Patent number: 9861590Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.Type: GrantFiled: September 22, 2011Date of Patent: January 9, 2018Assignee: Covidien LPInventors: Joshua Stopek, Garrett Ebersole, Amin Elachchabi, Daniel Broom
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Patent number: 9862807Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 ?m to about 100 ?m. A total diameter of the microsphere ranges from about 5 ?m to about 1000 ?m.Type: GrantFiled: October 6, 2014Date of Patent: January 9, 2018Assignee: The Regents of the University of MichiganInventors: Peter X. Ma, Zhanpeng Zhang
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Patent number: 9849182Abstract: Use of a moulding composition comprising a polymer and a setting agent for wound debridement, wherein said use comprises adding water to said moulding composition to form a moulding fluid, applying said moulding fluid to a surface of a wound, allowing said moulding fluid to set in contact with said surface to form a solid covering on said surface, followed by removing said solid covering from the wound. The alginate composition adheres strongly to bacterial biofilms on the wound, whereby the biofilms are removed with the alginate composition. The moulding composition may be used in conjunction with a staining agent that undergoes a color change in the presence of bacteria or bacterial polysaccharides to show the presence and removal of the biofilm. Also provided are methods of treating wounds using the compositions.Type: GrantFiled: April 24, 2012Date of Patent: December 26, 2017Assignee: KCI USA, Inc.Inventors: Lorna McInroy, Rachael Louise Clark, Michelle Delbono, Lorraine Nisbet, Paul Howard Lowing
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Patent number: 9840452Abstract: A novel highly stable sodium diacetate crystal, in which the volatilization of acetic acid can be suppressed for a long period. More specifically, a sodium diacetate crystal having a median diameter in the range of 300 to 3000 ?m.Type: GrantFiled: November 12, 2014Date of Patent: December 12, 2017Assignee: FUSO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Hideo Shimamura, Tadataka Murakami, Yasunori Kurata, Ayaka Kato
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Patent number: 9833418Abstract: The present invention relates to transdermal therapeutic systems that include an occlusive back layer impervious to an active substance, a single or multilayer matrix, and a peelable protective film. The matrix or at least one of the matrix layers includes a pharmaceutical active substance or a plurality of pharmaceutical active substances in the form of at least one pharmaceutically consumable salt thereof and a pharmaceutically consumable, alkaline reacting oxide.Type: GrantFiled: May 19, 2010Date of Patent: December 5, 2017Assignee: LTS Lohmann Therapie-Systeme AGInventors: René Eifler, Regine Kaufmann, Patrick Mohr
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Patent number: 9833540Abstract: The present invention relates to nanofibrillar polysaccharide hydrogels for use in the prevention and control of scarring and contraction in connection with wound healing or tissue repair.Type: GrantFiled: February 21, 2014Date of Patent: December 5, 2017Assignee: UPM-KYMMENE CORPORATIONInventors: Antti Laukkanen, Esko Kankuri, Kristo Nuutila
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Patent number: 9814765Abstract: Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).Type: GrantFiled: December 4, 2014Date of Patent: November 14, 2017Assignees: Ethicon, Inc., Omrix Biopharmaeuticals Ltd.Inventors: Yair Pilpel, Ashley Deanglis, Yuri Zherdev, Sivan Doron, Anne Gorman, Israel Nur