Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
-
Publication number: 20140377328Abstract: Provided is an intraoral soluble-type film preparation in which an unpleasant taste of a drug is masked. The intraoral soluble-type film preparation comprises a drug layer containing: a drug having a bitter taste and/or an astringent taste; an alkyl sulfate at a content of ¾ mol or more with respect to 1 mol of the drug; and a water-soluble polymer.Type: ApplicationFiled: December 12, 2012Publication date: December 25, 2014Applicant: KYUKYU PHARMACEUTICAL CO., LTD.Inventors: Akihiro Ishise, Hisanobu Nishikawa
-
Publication number: 20140377329Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.Type: ApplicationFiled: September 5, 2014Publication date: December 25, 2014Inventors: Nathan John BRYSON, Anthony John GIOVINAZZO, Scott David BARNHART, Michael Clinton KOONS
-
Patent number: 8916185Abstract: A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations thereof onto the surface. The surface and the particles are exposed to thermal treatment, vapor treatment or combinations thereof, thereby adhering at least some of the micro-particles, nano-particles or combinations thereof to the surface. Materials including such immobilized micro-particles, nano-particles or combinations thereof are also disclosed herein.Type: GrantFiled: February 27, 2008Date of Patent: December 23, 2014Assignee: The Regents of the University of MichiganInventors: Peter X. Ma, Guobao Wei
-
Publication number: 20140371692Abstract: Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto.Type: ApplicationFiled: April 29, 2014Publication date: December 18, 2014Applicants: A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS RUSSIAN ACADEMY OF SCIENCES, CORIUM INTERNATIONAL, INC.Inventors: Gary W. Cleary, Shoreh Parandoosh, Mikhail M. Feldstein, Anatoly E. Chalykh, Nicolai A. Platè, Valery G. Kulichikhin
-
Publication number: 20140370074Abstract: A method of in-situ adhering comprising providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of the pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with the water miscible polymer to the pre-gel; and allowing the pre-gel to cure and adhere onto the first surface.Type: ApplicationFiled: April 24, 2014Publication date: December 18, 2014Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Havazelet BIANCO-PELED, Ohad KIMHI
-
Patent number: 8911772Abstract: The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof. The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers.Type: GrantFiled: May 27, 2008Date of Patent: December 16, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventors: Hans-Dieter Sahm, Heinrich Thoeing, Wolfgang Laux
-
Patent number: 8911773Abstract: A peelable pouch comprises a substantially flat enclosure formed by first and second opposing flexible plies. A seat extends along at least a portion of a perimeter of the opposing plies. A flat, flexible transdermal patch is disposed in the enclosure and includes a bioactive agent dissolved in a layer of adhesive. A release liner is removably attached over the layer of adhesive, with the patch and the release liner together being sufficiently resilient so as to generate a spring force when displaced out of the flat configuration. The first and the second plies each being separable along the seal and displaceable out of the flat configuration. The spring force generated by the patch and the release liner being sufficient to overcome an adhesive force created by the adhesive between the patch and one of the plies.Type: GrantFiled: November 26, 2013Date of Patent: December 16, 2014Assignee: Watson Laboratories, Inc.Inventor: Michael W. Kimball
-
Patent number: 8911770Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.Type: GrantFiled: June 18, 2010Date of Patent: December 16, 2014Inventor: Alessandra Grassi
-
Patent number: 8911771Abstract: The present invention provides a device and a method for application of topical antiseptics. The device comprises a handle; a base coupled to the handle; and a substantially hydrophilic foam coupled to the base. The substantially hydrophilic foam is configured to receive the topical antiseptic.Type: GrantFiled: November 16, 2005Date of Patent: December 16, 2014Assignee: Otsuka America Pharmaceutical, Inc.Inventors: Patrick P. Vanek, Henry L. Lewkowicz
-
Publication number: 20140363484Abstract: The present invention is related to flexible, fibrous, biocompatible and biodegradable polymeric wafer; consists of more than one polymeric fibers, each one loaded with different therapeutic agents having mutually exclusive synergistic activity. The wafer is capable of delivering the drugs locally in to the diseased site like tumor, inflammation, wound, etc., in a controlled and sustained fashion for enhanced therapeutic effect. The combination of drugs loaded in the wafer is chosen in such a way that the second or consecutive drugs will enhance or improve the therapeutic effect of the first drug.Type: ApplicationFiled: August 21, 2014Publication date: December 11, 2014Applicant: Amrita Vishwa VidyapeethamInventors: MANZOOR KOYAKUTTY, RANJITH RAMACHANDRAN, SHANTIKUMAR NAIR
-
Publication number: 20140363485Abstract: The present invention relates to methods and products, such as wet wipes and absorbent articles, that are capable of imparting a health benefit when used in the intended fashion. More specifically, the products described herein comprise one or more botanical compounds, which are capable of selectively controlling the balance of flora on the skin. The compounds may enhance the adherence of healthy flora to the surface of skin or mucosa, inhibit the growth of problem flora on or around the skin surface, or inhibit the adherence of problem flora to the surface of skin or mucosa, or any combination thereof.Type: ApplicationFiled: August 22, 2014Publication date: December 11, 2014Inventors: David William Koenig, Beth A. Lange, Christine L. Schneider
-
Publication number: 20140363483Abstract: A method of treating or preventing Helicobacter pylori infection in a subject includes the step(s) of: administering to the subject a composition. The composition has a carbonaceous material and an active particle. The active particle is coated on the carbonaceous material and made of a material selected from the group consisting of silver, gold, aluminum, zinc, copper, and titanium dioxide.Type: ApplicationFiled: September 30, 2013Publication date: December 11, 2014Applicant: Feng Chia UniversityInventor: Tse-Hao KO
-
Patent number: 8906282Abstract: In embodiments of the present invention, a biodegradable/biodegradable polymer film may be used as a scaffold for tissue engineering scaffolds for engineering organized organs, such as vascular grafts, for example. In one embodiment, an ultraviolet (UV) resin made from a diacrylated biodegradable oligomer is molded into a flexible scaffold having cavities and/or channels. Channel/cavity size may be on the order of micrometers and/or nanometers, and thus the walls may have high aspect ratios. Smooth muscle cells may be deposited in the channels and because of the high aspect ratios, the cells may align along the channels/cavities as confluence is reached.Type: GrantFiled: July 6, 2005Date of Patent: December 9, 2014Assignee: Nanyang Technological UniversityInventors: Bee Eng Mary Chan, Jinye Shen, Bin He, Aiping Zhu, Yehai Yan, Chee Yoon Yue
-
Publication number: 20140356411Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.Type: ApplicationFiled: June 4, 2014Publication date: December 4, 2014Inventors: Donglei Fan, Xiaobin Xu
-
Patent number: 8900625Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.Type: GrantFiled: March 15, 2013Date of Patent: December 2, 2014Assignee: Nexmed Holdings, Inc.Inventors: Bassam B. Damaj, Richard M. Martin
-
Patent number: 8900624Abstract: The present invention comprises methods and compositions for antimicrobial silver compositions comprising silver nanoparticles. The present invention further comprises compositions for preparing silver nanoparticles comprising at least one stabilizing agent, one or more silver compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the silver compound comprises a salt comprising a silver cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates. The methods of the present invention comprise treating devices with the silver nanoparticle compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices.Type: GrantFiled: August 1, 2005Date of Patent: December 2, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Bhalchandra M. Karandikar, Bruce L. Gibbins, Ken A. Cornell
-
Publication number: 20140348898Abstract: Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms.Type: ApplicationFiled: August 12, 2014Publication date: November 27, 2014Inventor: Lawrence R. Bernstein
-
Patent number: 8895052Abstract: A composition comprising the reaction product of (a) an isocyanate group-containing component having an average functionality of at least 2; and (b) an active hydrogen group-containing component having an average functionality of at least 2. The composition is biodegradable, a solid at 22° C. and below, and has pressure sensitive adhesive properties at a temperature of 37° C. and relative humidity of 100%. The composition may be used to adhere polymer meshes or films to biological tissue.Type: GrantFiled: November 15, 2011Date of Patent: November 25, 2014Assignee: Cohera Medical, Inc.Inventors: Eric J. Beckman, Jessica L. Meyers
-
Patent number: 8895066Abstract: The invention relates to a bilayer composition for the delivery of acetaminophen and tramadol over at least a twelve hour period following initial administration. A single administration of the bilayer composition can provide analgesia starting in less than half an hour to about one hour after initial administration with a duration of at least twelve hours after initial administration.Type: GrantFiled: October 15, 2008Date of Patent: November 25, 2014Assignees: Paladin Labs Inc., Paladin Labs Europe Limited, Paladin Labs (Barbados) Inc.Inventors: Ali Bichara, Sonia Gervais, Dorothee Le Garrec, Patricia Ouadji, Vinayak Sant, Shiva Gosein, Vincent Lemaire, Samir Taga, Damon Smith
-
Publication number: 20140341963Abstract: A composition comprising at least one substance coated with an agent wherein the agent forms a liquid impermeable but gas permeable layer surrounding the said substance and preventing the passage of the said substance through said coating, wherein in-use the said substance is not released into solution in the body, and wherein said substance is selected from one or more of the group consisting of calcium phosphate, sodium chloride, potassium chloride, magnesium chloride, calcium carbonate, and sodium bicarbonate for use in the treatment of osteoporosis and other bone conditions.Type: ApplicationFiled: May 9, 2014Publication date: November 20, 2014Applicant: ActiveSignal Holding LimitedInventor: Ward Warren
-
Patent number: 8889179Abstract: The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (RPE) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. The membrane may also be used to support retinal pigmented epithelial cell precursors and retinal cell derivative cells formed from the differentiation of RPE on the membrane.Type: GrantFiled: January 3, 2014Date of Patent: November 18, 2014Assignee: UCL Business PLCInventors: Peter Coffey, Lyndon Da Cruz, Karen Cheetham
-
Patent number: 8889178Abstract: Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.Type: GrantFiled: March 14, 2013Date of Patent: November 18, 2014Assignee: Prosidyan, IncInventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
-
Publication number: 20140335148Abstract: An ultrafine fiber comprises a ceramic-based fibrous body and a biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body. In an example, an ultrafine fiber comprises a core comprising a biologically active substance and a ceramic-based shell surrounding or substantially surrounding the core.Type: ApplicationFiled: May 7, 2014Publication date: November 13, 2014Inventors: Ho-Wang Tong, Lawrence P. Wackett, Alptekin Aksan
-
Patent number: 8883196Abstract: A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.Type: GrantFiled: November 15, 2013Date of Patent: November 11, 2014Assignee: Agile Therapeutics, Inc.Inventor: Te-Yen Chien
-
Patent number: 8883194Abstract: The present invention utilizes a combination of a porous carrier and an adsorbent such as a molecular sieve to make a more effective hemostatic device to treat wounds in mammalian animals. These hemostatic devices contain additives that do not inhibit hemostasis.Type: GrantFiled: November 9, 2007Date of Patent: November 11, 2014Assignee: Honeywell International, Inc.Inventors: Robert L. Bedard, Steven A. Wilcher
-
Patent number: 8883193Abstract: Disclosed are composites that comprise regenerated cellulose, a first active substance, a second active substance, and a linker. Methods for preparing the composites that involve the use of ionic liquids are also disclosed. Articles prepared from the disclosed composites and methods of using them are further disclosed.Type: GrantFiled: June 5, 2007Date of Patent: November 11, 2014Assignee: The University of AlabamaInventors: Daniel T. Daly, Scott K. Spear, Megan B. Turner, Whitney Lauren Hough, Robin D. Rogers
-
Patent number: 8883195Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.Type: GrantFiled: March 14, 2013Date of Patent: November 11, 2014Assignee: Prosidyan, Inc.Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
-
Publication number: 20140328888Abstract: Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.Type: ApplicationFiled: July 21, 2014Publication date: November 6, 2014Applicant: Poly-Med, Inc.Inventors: Shalaby W. Shalaby, James M. Lindsey, Scott Taylor, David E. Linden, David R. Ingram
-
Patent number: 8877233Abstract: Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.Type: GrantFiled: June 28, 2002Date of Patent: November 4, 2014Assignee: Cook Biotech IncorporatedInventors: Joseph Obermiller, Michael C. Hiles
-
Patent number: 8877234Abstract: The invention relates to clear, liquid preservatives, which contain a) one or several 1-hydroxy-4-methyl-6-alkyl-2(1H)-pyridones and/or one or several salts thereof, wherein alkyl represents a linear, branched or cyclic alkyl group having 1-12 carbon atoms, and b) one or several alcohols containing one or several aromatic groups.Type: GrantFiled: January 25, 2006Date of Patent: November 4, 2014Assignee: Clariant Finance (BVI) LimitedInventors: Waltraud Simsch, {dot over (P)}eter Klug, Sonja Klein
-
Publication number: 20140322298Abstract: Described are transdermal drug delivery compositions comprising amphetamine, methods of making transdermal drug delivery compositions comprising amphetamine, and therapeutic methods of using them. In specific embodiments, the compositions are free of components with moieties that are reactive with amphetamine. In specific embodiments, the compositions are manufactured using solvents free of components with moieties that are reactive with amphetamine. Therapeutic methods using the compositions also are described.Type: ApplicationFiled: March 13, 2014Publication date: October 30, 2014Applicant: NOVEN PHARMACEUTICALS, INC.Inventors: Viet Nguyen, Jun LlAO, Prashant PATEL
-
Publication number: 20140322299Abstract: Dissolvable polymeric compositions are described which when exposed to certain pH conditions, controllably release one or more actives. The active agents can be nearly any active agent such as chlorhexidine gluconate (CHG). Also described are products using such compositions such as dressings. In addition, methods of controllably releasing one or more actives are described.Type: ApplicationFiled: November 14, 2012Publication date: October 30, 2014Inventor: Anne Marie Wibaux
-
Patent number: 8871245Abstract: A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl (meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxy group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.Type: GrantFiled: February 28, 2012Date of Patent: October 28, 2014Assignee: Nichiban Co., Ltd.Inventors: Takao Hiraoka, Shuta Nakanami, Toru Koga
-
Patent number: 8871267Abstract: The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents.Type: GrantFiled: February 5, 2010Date of Patent: October 28, 2014Assignee: Gel-Del Technologies, Inc.Inventor: David B. Masters
-
Patent number: 8871246Abstract: Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms.Type: GrantFiled: August 6, 2013Date of Patent: October 28, 2014Inventor: Lawrence Richard Bernstein
-
Publication number: 20140316333Abstract: A dissolving solid solution perforator (SSP) patch for oral cavity administration may include at least one perforator. The at least one perforator may contain a first drug and be configured to pierce an outside layer of an oral cavity for promptly delivering the first drug. The at least one perforator may penetrate an epithelium layer of the oral cavity and to deliver the antimigraine drug into blood vessels in a submucosa layer.Type: ApplicationFiled: October 29, 2012Publication date: October 23, 2014Inventor: Sung-Yun KWON
-
Publication number: 20140314828Abstract: In the prior art, there has not been provided a fiber that can quickly and persistently deodorize and absorb the smell and the damp feeling due to body fluid generated from the body. The present invention provides a fiber having such property, and specifically provides a moisture-absorbing and deodorizing fiber, characterized in that, a basic polymer is ionically-bonded in an amount of 0.2 to 4 mmol/g as an amount of amino group onto the surface of a moisture-absorbing fiber having a crosslinked structure and also having 3 to 8 mmol/g of carboxyl group.Type: ApplicationFiled: November 7, 2012Publication date: October 23, 2014Applicant: Japan Exlan Company LimitedInventor: Naoki Kawanaka
-
Publication number: 20140314829Abstract: Described herein are tooth whitening strips comprising an hydratable adhesive film having a granular bleaching ingredient attached thereto, wherein upon hydration, the granular bleaching ingredient releases hydrogen peroxide which is used by an enzyme catalyst having perhydrolytic activity to enzymatically produce an effective amount of peracid bleaching agent from an acyl donor substrate. Methods of making and use the tooth whitening strips are also provided.Type: ApplicationFiled: December 18, 2012Publication date: October 23, 2014Applicant: Colgate-Palmolive CompanyInventors: Thomas J. Boyd, Guofeng Xu, Richard Adams, Robert Pierce, Steven Miller, David Viscio, Kari A. Fosser, Robert Dicosimo, Hong Wang
-
Patent number: 8865205Abstract: Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.Type: GrantFiled: August 20, 2008Date of Patent: October 21, 2014Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
-
Patent number: 8865207Abstract: A blend of at least two polymers in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin.Type: GrantFiled: December 14, 2012Date of Patent: October 21, 2014Assignee: Noven Pharmaceuticals, Inc.Inventors: David Kanios, Rod Hartwig
-
Patent number: 8864047Abstract: Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles.Type: GrantFiled: July 20, 2009Date of Patent: October 21, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventors: Rudi Brathuhn, Peter Schwarz, Wolfgang Schaefer
-
Patent number: 8865206Abstract: Dermal delivery is best suited for the various skin diseases or disorders. However, the stratum corneum limits the permeation of number of suitable pharmaceutical agents for dermal delivery. Certain embodiments of the present invention include surface modified multilayered nanostructures. The modification was completed by using fatty acids enabling delivery of a significant amount of one or more pharmaceutical agent(s) into deeper layers of the epidermis and dermis to treat skin diseases or disorders. Each active pharmaceutical agent can be encapsulated into the separate layers of the nanostructures.Type: GrantFiled: December 10, 2013Date of Patent: October 21, 2014Assignee: Florida A&M UniversityInventors: Mandip Sachdeva, Punit Shah
-
Publication number: 20140308337Abstract: Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.Type: ApplicationFiled: March 5, 2014Publication date: October 16, 2014Applicant: The Regents of the University of CaliforniaInventors: Sarah Baker, April Sawvel, Galen D. Stucky
-
Publication number: 20140305835Abstract: An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.Type: ApplicationFiled: April 14, 2014Publication date: October 16, 2014Applicant: MONOSOL RX, LLCInventors: Robert K. Yang, Richard C. Fuisz, Garry L. Myers
-
Publication number: 20140308335Abstract: The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt.Type: ApplicationFiled: September 7, 2012Publication date: October 16, 2014Applicant: KM TRANSDERM LTD.Inventors: Atsuyo Hamada, Mitsuji Akazawa, Keiko Yamasaki, Masaoki Goto
-
Patent number: 8858986Abstract: Durable hydrophilic compositions comprising aliphatic polyester, an anionic surfactant, and in some embodiments, a carrier.Type: GrantFiled: June 11, 2009Date of Patent: October 14, 2014Assignee: 3M Innovative Properties CompanyInventors: Matthew T. Scholz, Francis E. Porbeni
-
Patent number: 8858985Abstract: Films comprising a liquid-absorbent layer with an adsorbed antimicrobial material and an impermeable layer are provided. The films can be suitable for preparation of tubular casings and shrinkbags such as casings for foodstuffs. Also disclosed are foodstuffs processed in the tubular casing comprising the antimicrobial material.Type: GrantFiled: May 11, 2005Date of Patent: October 14, 2014Assignee: E I du Pont de Nemours and CompanyInventors: I-Hwa Lee, Karlheinz Hausmann
-
Publication number: 20140302116Abstract: The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a substrate; and a multilayer film coated on the substrate, wherein adjacent layers of the multilayer film are associated with one another via one or more non-covalent interactions, wherein the multilayer film comprises a first nucleic acid agent present at a loading density, and further wherein the multilayer film is characterized in that, when the structure is placed on a subject so that the multilayer film contacts cells, the first nucleic acid agent is released with a profile characterized by a feature selected from the group consisting of 1) being a burst-free release; 2) being a sustained release; and 3) exhibiting in vitro and/or in vivo biological effectiveness.Type: ApplicationFiled: March 7, 2014Publication date: October 9, 2014Applicant: Massachusetts Institute of TechnologyInventors: Steven A. Castleberry, Paula T. Hammond
-
Publication number: 20140302117Abstract: Wiping products, such as facial tissues, contain a temperature change composition that can provide a cooling sensation when contacted with the skin of a user. The temperature change composition includes a phase change material and a non-interfering molecular scaffold. The phase change materials, in one embodiment, can have a relatively high heat of fusion. When undergoing a phase change, the temperature change composition absorbs heat and thereby provides a cooling feeling or cooling sensation to the skin of a user.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Inventors: Helen Kathleen Moen, Jeffery Richard Seidling, Scott W. Wenzel, Corey Thomas Cunningham
-
Patent number: 8852627Abstract: Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.Type: GrantFiled: July 15, 2013Date of Patent: October 7, 2014Assignee: KCI Licensing, Inc.Inventors: Archel Ambrosio, Joanna Payne