Bandages With Incorporated Medicaments Patents (Class 424/447)
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Publication number: 20140308337Abstract: Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.Type: ApplicationFiled: March 5, 2014Publication date: October 16, 2014Applicant: The Regents of the University of CaliforniaInventors: Sarah Baker, April Sawvel, Galen D. Stucky
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Patent number: 8858988Abstract: Compositions for the treatment of sores, wounds, burns and other traumatized dermal tissues and skin injuries comprising Boswellia gum, gel, resin or extract, Tea Tree oil (Melaleuca oil), an Aloe gel, resin, latex or extract and Lavender oil. The composition may be incorporated into a medical device such as a wound dressing or bandage, or formulated into a topical preparation such as an ointment, lotion or cream.Type: GrantFiled: November 2, 2010Date of Patent: October 14, 2014Assignees: CuraPhyte Technologies Inc., Nutriquine N.V.Inventors: Guy Chamberland, Peter Bollen
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Patent number: 8852627Abstract: Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.Type: GrantFiled: July 15, 2013Date of Patent: October 7, 2014Assignee: KCI Licensing, Inc.Inventors: Archel Ambrosio, Joanna Payne
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Publication number: 20140294919Abstract: The present invention relates to efficient devices for administration of pharmaceutical agents into the skin of the human body. In particular the present invention provides devices for vaccination into the skin. The present invention provides a pharmaceutical agent delivery device having skin-piercing portion comprising a solid reservoir medium containing the pharmaceutical agent, wherein the reservoir medium is coated onto the skin piercing portion. Alternatively, the skin piercing portion may consist of the solid pharmaceutical agent reservoir medium. The pharmaceutical delivery devices are proportioned such that agent is delivered into defined layers of the skin, and preferred delivery devices comprise skin-piercing portions that deliver the pharmaceutical agent into the epithelium or the dermis. Preferred reservoir media comprise sugars, and in particular stabilising sugars that form a glass such as lactose, raffinose, trehalose or sucrose.Type: ApplicationFiled: April 25, 2013Publication date: October 2, 2014Inventors: Colin Cave DALTON, Richard Lewis Easeman, Nathalie Garcon
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Patent number: 8846076Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.Type: GrantFiled: November 20, 2012Date of Patent: September 30, 2014Inventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Publication number: 20140276322Abstract: In one aspect, a wound treatment system includes an inner layer comprising a foam material impregnated with a zinc oxide containing composition with or without calamine and/or ichthammol and in the presence or absence of antimicrobial agent (inorganic and/or organic). An optional outer layer comprises a short/long stretch compression bandage. In another aspect, a method of manufacturing the foam article impregnated with the zinc oxide containing composition is disclosed. In yet another aspect, a method of applying the wound treatment system to a patient's leg is disclosed. In still another aspect, a kit is provided including a foam layer impregnated with a zinc oxide containing composition; optionally, an elastic bandage component (e.g., long or short stretch elastic bandage); and, optionally, an outer stocking or sleeve, wherein the bandage system components are packaged together.Type: ApplicationFiled: May 28, 2014Publication date: September 18, 2014Applicant: ANDOVER HEALTHCARE, INC.Inventors: Thomas S. Murphy, Khaled El-Tahlawy
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Publication number: 20140255465Abstract: The present invention provides novel methods of making a non-corrosive base solution for use as an alkalinity increasing agent and/or antioxidant. The present invention further provides novel compositions and methods which can be used to provide relief from acidosis, acidemia, and disorders related to or complicated by acidosis or excessive free radical or other reactive oxygen species production in mammalian subjects.Type: ApplicationFiled: March 9, 2014Publication date: September 11, 2014Applicant: COGNATE3 LLCInventors: Suzannah Jane ROBERTS, Stephanie Jo BLACKWELL, Shannon Joe BROWN
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Patent number: 8828358Abstract: A composition for in situ formation of an artificial blockage to control bleeding includes a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide. The decomposing agent includes exogenous or endogenous catalase, or both.Type: GrantFiled: March 11, 2008Date of Patent: September 9, 2014Assignee: Materials Modifications, Inc.Inventors: Joseph G. Montes, Krishnaswamy Kasthuri Rangan, Ramachandran Radhakrishnan, Tirumalai Srinivas Sudarshan
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Patent number: 8828425Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.Type: GrantFiled: January 29, 2011Date of Patent: September 9, 2014Assignee: Poly-Med, Inc.Inventors: Shalaby W. Shalaby, Joel T. Corbett, Jason M. Olbrich
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Patent number: 8821920Abstract: The invention relates to a topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive matrix based on polysiloxanes and containing capsaicin or a therapeutic compound analogous to capsaicin, and a protective film to be removed before use, in which the matrix contains liquid microreservoirs based on an amphiphilic solvent, in which the therapeutic compound is present in completely dissolved form and the concentration of the therapeutic compound in the microreservoir droplets is below the saturation concentration. The invention furthermore relates to a process for its production and its use in the treatment of neuropathic pain.Type: GrantFiled: April 12, 2004Date of Patent: September 2, 2014Assignee: LTS Lohmann Therapie Systeme AGInventor: Walter Müller
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Patent number: 8821916Abstract: A medical dressing comprising a complex of silver and being capable of releasing antimicrobial silver ion activity, said complex comprising silver and a transition element of Group IV of the periodic system of elements enables a controlled release of silver ion activity to a wound bed.Type: GrantFiled: January 4, 2008Date of Patent: September 2, 2014Assignee: Coloplast A/SInventor: Brian Nielsen
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Patent number: 8821918Abstract: Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.Type: GrantFiled: August 15, 2013Date of Patent: September 2, 2014Assignee: Boston Scientific Scimed Inc.Inventor: Richard J. Greff
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Patent number: 8821919Abstract: A method for debridement of wound on the skin by placing against the wound a glass-based borate-based composition to release dissolution products which support neutrophilic activity into the wound by dissolution.Type: GrantFiled: May 18, 2012Date of Patent: September 2, 2014Assignees: Mo/Sci Corporation, The Curators of the University of MissouriInventor: Steven B. Jung
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Patent number: 8809401Abstract: Disclosed is a composition for transdermal administration containing tolterodine. The composition comprises lidocaine or a pharmaceutically acceptable salt thereof to achieve enhanced skin penetration. The composition enhances the skin penetration of tolterodine. Therefore, a successful commercial application of a tolterodine-containing transdermal preparation based on the composition can be expected.Type: GrantFiled: February 17, 2011Date of Patent: August 19, 2014Assignee: SK Chemicals Co., Ltd.Inventors: Yong Youn Hwang, Won-Jae Choi, Jae-Sun Kim, Yeo-Jin Park, Joon-Gyo Oh, Bong-Yong Lee, Hae-In Rhee, Jong-Seob Im
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Patent number: 8809615Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: GrantFiled: October 26, 2009Date of Patent: August 19, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Patent number: 8802136Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.Type: GrantFiled: June 13, 2013Date of Patent: August 12, 2014Assignee: Mylan Technologies, Inc.Inventor: Kenneth J. Miller, II
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Publication number: 20140220103Abstract: A wound treatment system having a formulation to retard bleeding. In particular, the wound treatment system includes medical device, e.g. bandage, which can be adapted for internal or external use. The wound treatment system includes a fabric substrate having a formulation, wherein the formulation includes chitosan, kaolin, fibrinogen, and thrombin.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Matthew D. Bacchetta, Gopal Singh, Maurizio A. Miglietta
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Patent number: 8795718Abstract: The present invention utilizes a nano-coating of an oxide such as silica, a silicate or another effective oxide on a surface to accelerate blood clotting in mammalian animals. The hemostatic layer has a thickness that is effective for the hemostasis, yet can be made thin enough to result in a resorbable film which can either be applied to a biocompatible or resorbable device that can be used in surgical applications as well as in topical applications such as trauma.Type: GrantFiled: May 22, 2008Date of Patent: August 5, 2014Assignee: Honeywell International, Inc.Inventors: Robert L. Bedard, Steven A. Wilcher
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Patent number: 8795707Abstract: A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent.Type: GrantFiled: May 7, 2009Date of Patent: August 5, 2014Assignees: Trustees of Boston University, The Brigham and Women's Hospital, Inc.Inventors: Jesse Wolinsky, Mark W. Grinstaff, Yolonda L. Colson
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Patent number: 8790688Abstract: A wound care device for local treatment of pain in a wound is provided. The device comprises an active pain relieving composition, which can also be an anti-inflammatory agent. The wound care device is suitable for treatment of pain in open wounds. The device can include small amounts of pain relieving compositions that are effective in relieving pain at the wound while not resulting in any systemic effects. The device may be in the form of a wound dressing, and the pain relieving composition may be delivered to the wound through a controlled release system.Type: GrantFiled: December 19, 2002Date of Patent: July 29, 2014Assignee: Coloplast A/SInventors: Gitte Juel-Friis, Tine Richter-Friis, Truels Sterm Larsen
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Publication number: 20140205639Abstract: The present invention relates to pharmaceutical compositions suitable for the topical treatment of fungal infections of the skin and nails, such as tinea pedia and tinea cruris, among others. The active ingredients of the present compositions are low molecular weight organic acids and their salts, many of which are previously known as antifungal agents to some degree but which, when used in combination, produce a synergistic enhancement in antifungal potency such that the combined effect is greater than that when used by the agents alone. The antifungal activity of the active ingredients is further enhanced through the use of non-volatile hygroscopic solvents rather than the aqueous or volatile organic solvents used in the art.Type: ApplicationFiled: January 22, 2013Publication date: July 24, 2014Applicant: bioCEPTA CorporationInventor: Peter Mladenovich
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Patent number: 8784876Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: June 6, 2013Date of Patent: July 22, 2014Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8784874Abstract: A drug delivery device initially having two adhesive layers containing at least one active agent in each layer are kept separate from each other prior to administration of the active agent. At the time of administration, the separated layers are combined to form a dual layer adhesive transdermal drug delivery device which results in the administration of the at least one active compound after topical application of the device.Type: GrantFiled: September 10, 2004Date of Patent: July 22, 2014Assignee: Noven Pharmaceuticals, Inc.Inventor: Robert C. Strauss
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Publication number: 20140199360Abstract: Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogen-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity. The presence of the bacteriophages on a medical device, such as an indwelling medical device, prevents biofilm formation or reduces existing biofilm formation on the surface of the device when in use. These devices address the long felt need for biofilm resistant devices that increase safety and reduce complications normally associated with prior indwelling or other medical devices.Type: ApplicationFiled: June 28, 2012Publication date: July 17, 2014Applicant: CDC/The Govt. of the U.S.A. being rep. by Sec. of the Dept. of Hlth. and Human Svcs., Ctrs. for DisInventors: Rodney Martin Donlan, Susan Marie Lehman, Andres J. Garcia
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Patent number: 8778387Abstract: An antimicrobial medical dressing provides a combination of antimicrobial agents in various concentrations that protect against microorganisms, absorb exudates, and promote healing. The antimicrobial agents may include compositions of ethanol, hydrogen peroxide, and/or ethylenediaminetetraacetic acid.Type: GrantFiled: September 1, 2010Date of Patent: July 15, 2014Assignee: Hyprotek, Inc.Inventors: Patrick O. Tennican, L. Myles Phipps
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Patent number: 8771725Abstract: The present invention provides a method of treating a skin ailment including administering to a subject in need thereof, a therapeutically effective amount of a composition including (i) a primary diamine; (ii) a secondary aromatic diamine; (iii) a polyisocyanate; and (iv) optionally, a polyol. The present invention also provides a method of forming a skin bandage.Type: GrantFiled: October 2, 2008Date of Patent: July 8, 2014Assignee: Chesson Laboratory Associates, Inc.Inventors: Jerry Chesson, Timothy J. Romack, Lance L. Swick, David R. Terry
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Patent number: 8758311Abstract: A transdermal product delivery patch comprises a reservoir containing a product for delivery to a patient; means for affixing the patch to the skin of the patient; and manually operable means for actuating an extensor mechanism to exert pressure on the reservoir and thereby expel the product towards the skin. The patch may be supplied with the extensor mechanism held in a strained configuration and the manually operable means may be a restraint such as a peelable layer that can be removed to allow the extensor mechanism to move using stored energy towards a rest configuration. The extensor mechanism may be a ring of resilient material that is pre-stretched radially inwards so that, upon release, it stretches the reservoir radially outwards. The patch may be supplied with the extensor mechanism in a rest configuration and the manually operable means may deform it in a predefined manner into a strained configuration.Type: GrantFiled: August 1, 2011Date of Patent: June 24, 2014Assignee: Nemaura Pharma LimitedInventor: Dewan Fazlul Hoque Chowdhury
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Publication number: 20140170207Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.Type: ApplicationFiled: March 15, 2013Publication date: June 19, 2014Inventors: Bassam B. Damaj, Richard M. Martin
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Patent number: 8753669Abstract: An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.Type: GrantFiled: August 20, 2007Date of Patent: June 17, 2014Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Gary W. Cleary, Mikhail M. Feldstein, Valery G. Kulichikhin, Danir F. Bairamov
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Patent number: 8753670Abstract: A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing.Type: GrantFiled: March 26, 2008Date of Patent: June 17, 2014Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Yves A. Delmotte
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Patent number: 8747885Abstract: The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.Type: GrantFiled: December 15, 2004Date of Patent: June 10, 2014Assignees: Teikoku Seiyaku Co., Ltd., Drossapharm AGInventors: Tomohiro Ishima, Hiroyuki Yamasaki, Masahiro Yamaji
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Patent number: 8747887Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.Type: GrantFiled: October 3, 2005Date of Patent: June 10, 2014Assignee: KCI Medical ResourcesInventor: Arthur C. Coffey
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Patent number: 8741335Abstract: Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.Type: GrantFiled: July 13, 2006Date of Patent: June 3, 2014Assignee: HemCon Medical Technologies, Inc.Inventor: Simon J. McCarthy
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Publication number: 20140141057Abstract: Various compositions including vegetable oil are described. The compositions also include either or both of an adhesive component and a hydrocolloid component. The vegetable oil imparts a skin-soothing property in the resulting compositions. The compositions can be used in a wide range of medical products and consumer healthcare goods.Type: ApplicationFiled: June 19, 2012Publication date: May 22, 2014Applicant: Avery Dennison CorporationInventors: Anne Marie Wibaux, Vicky Van De Pol
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Patent number: 8728513Abstract: A wound dressing having anti-microbial activity comprises a first fiber capable of bonding with silver (1) cations. The wound dressing comprises a blend of the first fiber to which silver (1) cations are bonded and a second fiber which is substantially free from silver. The wound dressing comprises from 0.01 to 5.0 percent by weight of silver (1) cations, based on the weight of fiber.Type: GrantFiled: February 14, 2013Date of Patent: May 20, 2014Assignee: Convatec Technologies Inc.Inventor: David Malcolm Woods
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Patent number: 8729235Abstract: The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.Type: GrantFiled: November 21, 2013Date of Patent: May 20, 2014Assignee: Spiber Technologies ABInventors: Jan Johansson, Gäran Hjäm, Margareta Stark, Anna Rising, Stefan Grip, Wilhelm Engsträm, My Hedhammar
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Patent number: 8715701Abstract: Protein preparations containing biologically active compounds and the application of the protein preparations obtained, particularly as a component of medicinal and cosmetic preparations as protective substances or in the regeneration of cells and tissues of the human organism, and which can comprise a component of culture media for dermal or hepatic tissues, or for stem cells destined for use in the regeneration of cells and tissues in the human organism.Type: GrantFiled: November 20, 2007Date of Patent: May 6, 2014Assignee: Instytut Medycyny Doswiadczalnej I KlinicznejInventors: Andrzej Lipkowski, Anna Grabowska, Katarzyna Kurzepa, Aleksandra Szczucinska
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Patent number: 8710290Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of manufacturing a therapeutic device for promoting the healing of a wound in a mammal comprising the steps of providing a permeable substrate, and forming a plurality of depressions into a surface of the permeable substrate to provide the therapeutic device. A method of treating a wound comprises: providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: GrantFiled: July 5, 2012Date of Patent: April 29, 2014Assignee: Boehringer Technologies, L.P.Inventors: John R. Boehringer, John Karpowicz, Amitabha Mitra, Christopher L. Radl
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Patent number: 8707962Abstract: A device for protecting an area of skin of a human body includes a plate. The plate includes a first face covered by an external layer and a second face opposite the external layer. The second face is configured to be applied onto an area of skin to be protected. The plate also includes a protective part made of a polymer gel and at least one adhesive part made of a polymer gel. The protective part is configured to ensure mechanical protection of the area to be protected and the adhesive part is configured to come into contact with the skin. The adhesive part has an adhesive power greater than an adhesive power of the protective layer to hold the plate on the area to be protected.Type: GrantFiled: August 3, 2011Date of Patent: April 29, 2014Assignee: Millet InnovationInventors: Jean-Pierre Dominguez, Damien Millet, Jean-Claude Millet
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Publication number: 20140112974Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer is 5 to 13.2% by mass relative to a total mass of the adhesive agent layer.Type: ApplicationFiled: May 23, 2012Publication date: April 24, 2014Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yuka Takagi, Naoyuki Uchida, Yasunari Michinaka
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Patent number: 8703634Abstract: Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.Type: GrantFiled: February 13, 2008Date of Patent: April 22, 2014Assignee: The Regents of the University of CaliforniaInventors: Sarah Baker, April Sawvel, Galen D. Stucky
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Publication number: 20140086976Abstract: Provided herein are compositions containing a vaccinia virus and a protein polymer, and articles of manufacture thereof. Also provided are diagnostic and therapeutic methods using the compositions or articles of manufacture.Type: ApplicationFiled: August 20, 2013Publication date: March 27, 2014Inventors: Aladar A. Szalay, Nanhai George Chen
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Patent number: 8679528Abstract: The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.Type: GrantFiled: September 28, 2012Date of Patent: March 25, 2014Assignee: American National Red CrossInventors: Martin J. MacPhee, Dawson Beall, Stanley Friedman
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Patent number: 8679523Abstract: The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.Type: GrantFiled: December 29, 2000Date of Patent: March 25, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Bruce L. Gibbins, Lance D. Hopman
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Patent number: 8679526Abstract: The present invention discloses a class of compounds which have an enhancing effect on peroxidase based antimicrobial compositions. The invention relates to pharmaceutical compositions for prolonged topical use comprising enhancing agents such as methoxyphenols and substituted benzylaldehydes. Examples hereof are respectively guaiacol and vanillin.Type: GrantFiled: June 13, 2006Date of Patent: March 25, 2014Assignee: Flen Pharma N.V.Inventors: Dave Van Den Plas, Kris De Smet, Philippe Sollie
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Patent number: 8679527Abstract: This invention provides antimicrobial compositions containing methylglyoxal and material with methylglyoxal contained (such as manuka honey). The antimicrobial activity of methylglyoxal, or material with a methylglyoxal presence, is maintained and/or enhanced by mixing methylglyoxal or material with a methylglyoxal presence with cyclodextrin. Methods of preparing such compositions, including powder composition, and methods of using such compositions are also provided.Type: GrantFiled: October 12, 2009Date of Patent: March 25, 2014Assignee: Manuka Health New Zealand LimitedInventors: Terao Keiji, Ayako Jo, Daisuke Nakata
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Patent number: 8673345Abstract: A kit and methods for delivering an effective amount of a labile active to the skin are provided. The kit and methods comprise a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.Type: GrantFiled: January 3, 2008Date of Patent: March 18, 2014Assignee: E-L Management Corp.Inventors: Andrew J. Bevacqua, Peter J. Lentini, Tracy N. Keeler, Julius R. Zecchino, Pauline Vassiliou
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Publication number: 20140072614Abstract: Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.Type: ApplicationFiled: February 28, 2013Publication date: March 13, 2014Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.Inventors: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
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Patent number: 8664464Abstract: The invention provides wound dressings comprising an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticized hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticized hydrophilic polymer matrix having relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive.Type: GrantFiled: December 12, 2003Date of Patent: March 4, 2014Assignee: Systagenix Wound Management (US), Inc.Inventors: Hugh S. Munro, Derek Silcock, Simon W. Bayliff, Richard Hoskins, Susana S. Garcia, Helen Burgess, Justin Barnes
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Publication number: 20140052051Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: ApplicationFiled: October 28, 2013Publication date: February 20, 2014Applicant: NITTO DENKO CORPORATIONInventors: FRANK TAGLIAFERRI, ALAN SMITH, DAVID ENSCORE, GAURAV TOLIA, MIREK BAUDYS