Bandages With Incorporated Medicaments Patents (Class 424/447)
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Patent number: 8383148Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: June 18, 2012Date of Patent: February 26, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8383527Abstract: An antimicrobial composite which comprises a first, liquid-permeable layer which is substantially completely bonded to a second liquid-absorbing layer. The first layer comprises a coating of at least one antimicrobial metal as such on the side which is bonded to the second layer. Substantially no antimicrobial metal in elemental form is present on exterior surfaces of the composite.Type: GrantFiled: September 23, 2008Date of Patent: February 26, 2013Assignee: Beiersdorf AGInventors: Peter Hilfenhaus, Heike John, Harald Büttner
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Patent number: 8383147Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: August 22, 2012Date of Patent: February 26, 2013Assignee: Ethicon, Inc.Inventors: Dhanuraj S. Shetty, Olajompo Moloye-Olabisi, Robert W. Van Holten, Degang Zhong
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Patent number: 8377467Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.Type: GrantFiled: March 2, 2012Date of Patent: February 19, 2013Assignees: The University of North Carolina at Chapel Hill, Entegrion, IncInventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
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Patent number: 8377468Abstract: Dry dressings incorporate drug-delivery systems for anti-infective agents, growth factors, fibronectin or other substances to enhance tissue healing. A pharmaceutical composition includes hyaluronate polyvinylpyrrolidone (PVP), maltodextrin, and hydroxyethylcellulose and glycerin in the form of a membranous, wafer-like material after being freeze-dried.Type: GrantFiled: August 28, 2007Date of Patent: February 19, 2013Assignee: Rexaderm, Inc.Inventor: Clyde R. Goodheart
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Patent number: 8377016Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.Type: GrantFiled: January 10, 2007Date of Patent: February 19, 2013Assignee: Wake Forest University Health SciencesInventors: Louis O. Argenta, Michael J. Morykwas, Lawrence X. Webb
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Patent number: 8367100Abstract: Novel micro-encapsulated topical analgesics are provided to treat pain and may be applied via sleeves having dosed therapeutic sections, especially to joints and extremities. Sleeves may be prepared and packaged inside-out and inverted when positioned by the wearer.Type: GrantFiled: August 24, 2010Date of Patent: February 5, 2013Assignee: Chattem, Inc.Inventors: Shane C Smith, Joseph Czerwinski, Mike Davies, Don Moak, Blair Ramey
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Patent number: 8367099Abstract: A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.Type: GrantFiled: September 22, 2006Date of Patent: February 5, 2013Assignee: Atrium Medical CorporationInventors: Steve A. Herweck, Thomas M. Swanick, Joseph Ferraro, Paul Martakos, Lisa Rogers, Theodore Karwoski, Keith M. Faucher, Philip McNamara, Roger Labrecque, Suzanne Conroy, Trevor Carlton
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Patent number: 8366688Abstract: A sterilized non-discolored eyelid cleansing pad, which has been sterilized by exposure to ?-radiation in a dose level of 2 Mrad.Type: GrantFiled: June 28, 2006Date of Patent: February 5, 2013Assignee: Fischer Pharmaceuticals Ltd.Inventor: Josef Pesso
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Patent number: 8349354Abstract: The present invention is directed to a hemostatic composite structure having a bioabsorbable fabric or non-woven substrate having at least two major oppositely facing surface areas and a continuous non-porous polymer-based film that is laminated on one major surface of said substrate. The bioabsorbable fabric substrate can be an oxidized polysaccharide and/or the non-woven substrate can be made from bioabsorbable, non-cellulosic derived polymers. The continuous non-porous polymer based film can be a bioabsorbable polymer. The present invention also relates to a method for providing hemostasis by applying a composite structure described herein onto a wound site in need of a hemostatic device wherein a major surface of the substrate without the film layer is applied onto the wound site.Type: GrantFiled: September 22, 2009Date of Patent: January 8, 2013Assignee: Ethicon, Inc.Inventor: Sasa Andjelic
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Patent number: 8349355Abstract: The present invention relates to novel formulations comprising lipoic acid and hyaluronic acid and/or the derivatives thereof for use in the repair of chronic ulcers, the regeneration of damaged skin, the prevention of skin aging and, when administered by the systemic route, to treat peripheral neuropathies and intoxications by chemical and/or biological agents.Type: GrantFiled: May 24, 2006Date of Patent: January 8, 2013Assignee: Anika Therapeutics S.R.L.Inventors: Carlo Soranzo, Doriana Senigaglia, Davide Bellini
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Patent number: 8349120Abstract: A muco-adhesive patch for delivery of drugs into mucous membranes. On the muco-contact side, a water impermeable layer covers the center of the patch and less than half of the muco-contact side of the patch. Drugs may be added by mixing the drug with an adhesive material and placing a spot of the drug plus adhesive onto the exposed side of the water impermeable layer. A lenticular medical patch with a thin, tapered edge can be made with multiple layers by passing a single sheet such as a sheet of plastic through a production line in which each layer is applied in turn maintaining registration by reference to edges of the sheet or to marks on the sheet.Type: GrantFiled: September 5, 2008Date of Patent: January 8, 2013Assignee: Ora Health CorporationInventor: Jeffrey T Haley
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Patent number: 8349356Abstract: The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita) and the leaves of dioecious nettle (Urtica dioica). Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with excellent and broad spectrum hemostatic capabilities, with concurrent antiseptic and anti-inflammatory properties. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile and nettle components is applied to a textile or fabric material, for example a non-woven viscose.Type: GrantFiled: September 23, 2011Date of Patent: January 8, 2013Inventors: Natalia Dmitrievna Oltarshevskaya, Larisa Borisovna Savilova, German Evseevich Krichevsky
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Patent number: 8349357Abstract: The present invention provides an adhesive patch comprising a support, an adhesive layer on at least one surface of the support, and a release liner on a surface of the adhesive layer opposite from the support, wherein (a) the lateral end of the adhesive layer is exposed, (b) in at least one lateral end, the lateral end of the adhesive layer is located toward the central part side of the adhesive patch from the lateral end of the support, and (c) when placed horizontally with the release liner facing down, a distance A between the upper end of the support and the lower end of the release liner at said lateral end of the adhesive patch is greater than a thickness B of the central part of the adhesive patch.Type: GrantFiled: September 1, 2011Date of Patent: January 8, 2013Assignee: Nitto Denko CorporationInventors: Jun Harima, Masakatsu Konno, Ryo Hashino, Akira Numata
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Patent number: 8343537Abstract: A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.Type: GrantFiled: January 31, 2012Date of Patent: January 1, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Publication number: 20120328690Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: ApplicationFiled: April 23, 2012Publication date: December 27, 2012Applicant: Bio-Tissue, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8329211Abstract: The present invention is directed to a synthetic fabric comprising a multi-layered nonwoven fabric made from staples of a polyglycolide/polylactide copolymer, each layer having a different density. The multi-layer fabric can be used as a reinforced absorbable hemostat medical device.Type: GrantFiled: May 17, 2010Date of Patent: December 11, 2012Assignee: Ethicon, Inc.Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
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Publication number: 20120308637Abstract: Compositions for the treatment of sores, wounds, burns and other traumatized dermal tissues and skin injuries comprising Boswellia gum, gel, resin or extract, Tea Tree oil (Melaleuca oil), an Aloe gel, resin, latex or extract and Lavender oil. The composition may be incorporated into a medical device such as a wound dressing or bandage, or formulated into a topical preparation such as an ointment, lotion or cream.Type: ApplicationFiled: November 2, 2010Publication date: December 6, 2012Inventors: Guy Chamberland, Peter Bollen
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Publication number: 20120308639Abstract: The present invention relates to hemostatic compositions comprising a mesocellular oxide foam and, optionally, a biologically active agent such as a procoagulant, as well as devices and methods of use to promote blood clotting.Type: ApplicationFiled: May 2, 2012Publication date: December 6, 2012Inventors: Galen Stucky, Sarah Baker, April Sawvel
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Patent number: 8323684Abstract: The invention relates to a TTS with backing layers that guarantee a high wear comfort and that facilitate application in regions of the human body that are subject to great mechanical loads, especially the large joints of the extremities. The inventive backing layers overcome the disadvantages with respect to reduced absorption of the active substance by the skin that are typically associated with such backing layers. The inventive systems are preferably used for the local of systemic administration of anti-inflammatory and pain-relieving active substances.Type: GrantFiled: May 15, 2001Date of Patent: December 4, 2012Assignee: LTS Lohmann Therapie-Systeme AGInventors: Stefan Bracht, Christoph Schmitz
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Patent number: 8318197Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: GrantFiled: January 17, 2012Date of Patent: November 27, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Publication number: 20120294928Abstract: Methods of treating disorders mediated by ?-catenin comprising administration of Nefopam compounds are provided In particular, the treatment of disorders arising from excessive or undesired expression of ?-catenin is contemplated Said compounds include Nefopam, analogues thereof, prodaigs thereof, and salts and solvates of Nefopam The ?-catenin mediated disorders are preferably selected from the group consisting of fibroproliferative disorders (such as scars, aggressive fibramtoses, and fibroses) and cancer (such as colon cancer, melanoma, liver cancer, ovarian cancer, endometrial cancer, medullobalstoma pilomatricomas, and prostate cancer)Type: ApplicationFiled: December 15, 2010Publication date: November 22, 2012Inventors: Benjamin A. Alman, Raymond Poon, Helen Hong
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Patent number: 8313764Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: GrantFiled: June 20, 2011Date of Patent: November 20, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Linda O. Palladino
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Publication number: 20120269880Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: ApplicationFiled: April 3, 2012Publication date: October 25, 2012Applicant: Tissue Tech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8293268Abstract: Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms.Type: GrantFiled: March 14, 2012Date of Patent: October 23, 2012Inventor: Lawrence Richard Bernstein
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Patent number: 8288334Abstract: The present invention relates to new peptides, pharmaceutical composition and cosmetic composition including them and their use for wound healing.Type: GrantFiled: June 14, 2010Date of Patent: October 16, 2012Assignee: Gene Signal International SAInventors: Salman Al-Mahmood, Sylvie Colin
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Patent number: 8287899Abstract: The invention relates to a patch for cutaneous application of a substance, the patch comprising a substance designed to penetrate the epidermis, means for placing the substance in contact with the skin and a peelable cutaneous exfoliation film enabling exfoliation of the skin, after placing the patch, at the level of the contact zone between said substance and the skin.Type: GrantFiled: February 15, 2008Date of Patent: October 16, 2012Assignee: DBV TechnologiesInventor: Bertrand Dupont
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Patent number: 8287900Abstract: There is provided a medicated patch including 5-methyl-1-phenyl-2-(1H)-pyridone. A medicated patch comprising a percutaneously absorbable preparation layer, wherein the percutaneously absorbable preparation layer includes 5-methyl-1-phenyl-2-(1H)-pyridone or a pharmaceutically acceptable salt thereof as an active component, a dissolving agent and an aqueous base material (or a rubber-type base material), and the active component is contained in an amount of 0.1 to 30 mass % relative to the total amount of the percutaneously absorbable preparation layer.Type: GrantFiled: May 26, 2008Date of Patent: October 16, 2012Assignees: Lead Chemical Co., Ltd., Shionogi & Co., Ltd.Inventors: Takayasu Matsuzawa, Tamaki Horiuchi, Seijiro Yama, Tetsukazu Hamamoto, Sunao Takeuchi, Daisuke Ichimatsu
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Patent number: 8283513Abstract: A flexible, multilayer wound dressing with antibacterial and antifungal properties, together with methods for making the dressing. The dressing includes a layer of silver-containing fabric, a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.Type: GrantFiled: September 6, 2005Date of Patent: October 9, 2012Assignee: Argentum Medical, LLCInventors: Robert O. Becker, A. Bartholomew Flick, Adam J. Becker
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Patent number: 8277837Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.Type: GrantFiled: January 8, 2007Date of Patent: October 2, 2012Assignees: Entegrion, Inc., University of North Carolina at Chapel HillInventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
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Patent number: 8273369Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: May 17, 2010Date of Patent: September 25, 2012Assignee: Ethicon, Inc.Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
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Patent number: 8273368Abstract: Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.Type: GrantFiled: January 20, 2012Date of Patent: September 25, 2012Assignee: KCI Licensing, Inc.Inventors: Archel Ambrosio, Joanna Payne
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Patent number: 8263116Abstract: A method for producing a silver-bonded antimicrobial moist wound dressing. A silver-containing compound is added to a 0.1-30% aqueous solution of an alkaline solvent to dissociate silver ions from the silver-containing compound, dissolving CMC in water or an organic solvent to obtain a CMC solution, the silver ion-containing solution is mixed with the CMC solution so that the hydrogen ions (H+) of the hydroxyl groups of the CMC are replaced by the silver ions to prepare a silver-CMC compound, the silver-CMC compound is dispersed and absorbed in a medium, and the medium is dried.Type: GrantFiled: March 9, 2007Date of Patent: September 11, 2012Assignee: Cellulose Concepts, LLCInventors: Yoong-Soo Kim, Ju-Young Kim
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Publication number: 20120225108Abstract: Morpholino compounds of Formula (I) wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or pharmaceutically acceptable salts thereof, have been found to be surprisingly effective at promoting the healing of a wound.Type: ApplicationFiled: May 21, 2012Publication date: September 6, 2012Applicant: SINCLAIR PHARMACEUTICALS LIMITEDInventor: OLOF TORGNY SJODIN
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Patent number: 8257732Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: May 25, 2011Date of Patent: September 4, 2012Assignee: Z-Medica CorporationInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8257731Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining molecular sieve material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a rigid or semi-rigid support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attached to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate molecular sieve material is in direct contact with blood.Type: GrantFiled: September 9, 2009Date of Patent: September 4, 2012Assignee: Z-Medica CorporationInventors: Jeffry Horn, Raymond Huey
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Publication number: 20120219612Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Inventors: Robert F. Diegelmann, Kevin R. Ward, Marcus E. Carr, Gary Lee Bowlin
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Patent number: 8252318Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.Type: GrantFiled: November 2, 2006Date of Patent: August 28, 2012Assignee: Z-Medica CorporationInventors: Raymond J. Huey, Jeffrey L. Horn
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Patent number: 8252317Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: GrantFiled: February 26, 2009Date of Patent: August 28, 2012Assignee: General Electric CompanyInventors: Andrew Soliz Torres, Peter John Bonitatibus, Jr.
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Patent number: 8246979Abstract: An improved transdermal delivery system (TDS) comprises a self-adhesive matrix comprising a solid or semi-solid semi-permeable polymer which contains rotigotine in its free base form as a multitude of microreservoirs within the matrix. The self-adhesive matrix is highly permeable to the free base of rotigotine and is impermeable to the protonated form of rotigotine.Type: GrantFiled: July 22, 2003Date of Patent: August 21, 2012Assignee: UCB Pharma GmbHInventors: Dietrich Wilhelm Schacht, Mike Hannay, Hans-Michael Wolff
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Publication number: 20120207815Abstract: The present invention relates to the treatment of EE. More specifically, the invention relates to a new method of treating EE through the epicutaneous route. In particular, the method of the invention comprises applying to the skin of the subject a skin patch device, comprising a composition, under conditions allowing a contact between said composition and the skin. The present invention also relates to the skin patch device and to a use of the skin patch device in the manufacture of a composition for treating eosinophilic esophagitis in a subject.Type: ApplicationFiled: March 6, 2012Publication date: August 16, 2012Inventors: Pierre-Henri Benhamou, Lucie Mondoulet
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Patent number: 8241660Abstract: This invention relates to a patch for the expulsion of insect poison from the skin after stings from membranous insects (Hymenoptera). The patch is characterized in comprising a poison-aspirating matrix comprising an expulsion agent as well as a swell layer, which swells after the addition of a liquid through a hole on the top of the patch and thus adds a light pressure to the poison-aspirating matrix towards the skin, whereby a local and relieving effect is achieved. In one embodiment, the matrix further comprises a local anesthetic. The expulsion agent is e.g. a carbohydrate. The swell layer consists e.g. of a silica gel.Type: GrantFiled: August 20, 2007Date of Patent: August 14, 2012Inventor: Martin Wenckens
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Patent number: 8237010Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of manufacturing a therapeutic device for promoting the healing of a wound in a mammal comprising the steps of providing a permeable substrate, and forming a plurality of depressions into a surface of the permeable substrate to provide the therapeutic device. A method of treating a wound comprises: providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: GrantFiled: August 30, 2011Date of Patent: August 7, 2012Assignee: Boehringer Technologies, L.P.Inventors: John R. Boehringer, John Karpowicz, Christopher L. Radl
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Patent number: 8226965Abstract: The present invention relates to methods for treating and completely curing fungal, yeast, and/or mold infections in human subjects comprising topically administering to a human subject in need thereof an antifungal nanoemulsion composition.Type: GrantFiled: April 27, 2009Date of Patent: July 24, 2012Assignee: NanoBio CorporationInventors: James R. Baker, Jr., Mary R. Flack, Susan Marie Ciotti, Joyce A. Sutcliffe
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Publication number: 20120177715Abstract: The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from a naturally occurring protein which modulates blood coagulation, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, for use in the treatment or prevention of inflammation and/or excessive coagulation of the blood. Related aspects of the invention provide isolated polypeptides comprising or consisting of an amino acid sequence of SEQ ID NOS: 1 to 3, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, which exhibit an anti-inflammatory activity, together with isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of inflammation and/or excessive coagulation.Type: ApplicationFiled: September 21, 2010Publication date: July 12, 2012Applicant: XIMMUNE ABInventors: Martina Kalle, Gopinath Kasetty, Nils Martin Malmsten, Praveen Papareddy, Artur Schmidtchen, Björn Ulrik Walse
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Patent number: 8217011Abstract: Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.Type: GrantFiled: March 7, 2008Date of Patent: July 10, 2012Assignee: The Queen's University of BelfastInventors: Christopher Shaw, Tianbao Chen, Martin O'Rourke, Brian Walker, David Hirst
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Patent number: 8211456Abstract: The present invention relates to “grafting to” methods of modifying materials surfaces with high-density polymer brushes. A method of the present invention comprises contacting in succession or simultaneously an activated material surface, a solution of a polymeric material having a polymeric backbone with pendant reactive moieties, and a melt of brush-forming terminally-functionalized polymer chains, in order to allow a covalent bonding reaction to occur between surface and polymers, wherein upon completion of the reaction, the polymeric material forms a layer between the material surface and the brush polymer chains.Type: GrantFiled: August 16, 2006Date of Patent: July 3, 2012Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNOInventors: Joost Hubert Maas, Aafke Tessa Ten Cate, Ralf Guillaume Jean Catharina Heijkants
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Patent number: 8202532Abstract: Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding wound when the device is in particle form and the clay material can promote hemostasis.Type: GrantFiled: November 3, 2009Date of Patent: June 19, 2012Assignee: Z-Medica CorporationInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8187625Abstract: Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.Type: GrantFiled: February 4, 2002Date of Patent: May 29, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Richard J. Greff
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Patent number: 8183427Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.Type: GrantFiled: December 7, 2010Date of Patent: May 22, 2012Inventors: Bronislava G. Belenkaya, Valentina I. Sakharova, Vyacheslav N. Polevov, Claudia Polevov, legal representative