Sodium Containing Or Fluorine Containing Patents (Class 424/606)
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Patent number: 6156740Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.Type: GrantFiled: December 1, 1999Date of Patent: December 5, 2000Assignee: Rhone-Poulenc AgrochimieInventor: Patrice Duvert
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Patent number: 6123966Abstract: A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid and an alcohol-containing humectant or antifreeze, while the second part contains a salt of an organic acid and an optional metal chlorite. Methods for making a disinfecting composition by mixing the two-part disinfecting system, as well as for disinfecting substrates by contact therewith, are also disclosed.Type: GrantFiled: September 3, 1998Date of Patent: September 26, 2000Assignee: Alcide CorporationInventor: Robert D. Kross
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Patent number: 6113949Abstract: This invention relates to a weight control composition, preferably in the form of a capsule or tablet, comprising a mixture of guggul extract and at least one phosphate salt selected from calcium phosphate, potassium phosphate and sodium phosphate. The composition evidences synergistic activity in reducing body weight and percent body fat in mammals. The guggul extract/phosphate salt product also reduces plasma lipid levels and cholesterol in overweight hyperlipidaemic humans. The inventive composition may also contain at least one additional component selected from phosphatidylcholine, hydroxycitric acid and L-tyrosine.Type: GrantFiled: October 27, 1998Date of Patent: September 5, 2000Assignee: Prolab Nutrition, Inc.Inventor: William DesIsles Brink
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Patent number: 6063406Abstract: The present invention includes a process and composition for treating skin disorders. The composition of the present invention comprises 94.0 to 99.2 percent by weight of cation-free water, 0.1 to 1.0 percent by weight of Calcium chloride, 0.0 to 2.0 percent by weight of linear long chain polyphosphate, 0.1 to 1.0 percent by weight of sodium bicarbonate and 0.5 to 3.0 percent by weight of cross-linked polyacrylamide polymer.Type: GrantFiled: April 17, 1998Date of Patent: May 16, 2000Assignee: Chemcraft, Inc.Inventor: Richard S. Hornack
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Patent number: 6024985Abstract: The invention provides a synthetic bone precursor material comprising amorphous calcium phosphate and a constituent that inhibits the crystallisation of calcium hydroxyapatite to amorphous calcium phosphate. The synthetic bone precursor may comprise a material of formula CaxMgyPO4 wherein Mg acts as an inhibitor for crystallisation. Other crystallisation inhibitors such as pyrophosphate may be present. The inhibitor is capable of dissolving in physiological saline. Loss of inhibitor from the precursor allows crystallisation of hydroxyapatite. The invention relates to use of a synthetic bone precursor to form bone in vivo, by a transformation of the amorphous precursor material to crystalline hydroxyapatite bone material by the leaching action on inhibitory ions body fluids. it is envisaged that the material will be useful in facilitating bone repair, inducing bone formation or assisting in the attachment of prostheses.Type: GrantFiled: April 5, 1995Date of Patent: February 15, 2000Assignee: University of ReadingInventors: Kenneth Simkiss, Marina Gloria Taylor
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Patent number: 6015802Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.Type: GrantFiled: May 13, 1998Date of Patent: January 18, 2000Assignee: Rhone-Poulenc AgrochimieInventor: Patrice Duvert
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Patent number: 5993862Abstract: A formed cream substitute for the addition to hot meals and a method for its preparation. The formed cream substitute for the addition to hot meals is formed by working 20 to 60% cream powder and 10 to 50% fat powder in a 15 to 50% matrix of pure fat. The cream substitute according to the invention can be provided in the form of lumps, in the form of cubes, or in the form of a granulate. The cream substitute can be stored well at room temperature and has, on a weight basis, a higher effectiveness than liquid cream.Type: GrantFiled: November 6, 1996Date of Patent: November 30, 1999Assignee: CPC International Inc.Inventors: Florian Biller, Karin Frank, Richard Kellermann, Gerhard Schneider
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Patent number: 5962028Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.Type: GrantFiled: October 16, 1992Date of Patent: October 5, 1999Assignee: Norian CorporationInventor: Brent R. Constantz
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Patent number: 5952010Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like.Type: GrantFiled: December 9, 1997Date of Patent: September 14, 1999Assignee: Norian CorporationInventor: Brent R. Constantz
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Patent number: 5935607Abstract: A method of treating osteoporosis is disclosed by administering orally a single daily dosage of phosphate in the evening in an amount, e.g., about 10 mg/kg body weight or less which is effective to raise serum parathyroid hormone levels of the subject being treated.Type: GrantFiled: February 15, 1996Date of Patent: August 10, 1999Assignee: Hadasit Medical Research Services and Development Company Ltd.Inventor: Justin Silver
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Patent number: 5906986Abstract: A fungicidal composition comprising a compound A having the formula: ##STR1## wherein M is an oxygen or sulphur atom, n is 0 or 1, and Y is a fluorine or chlorine atom or a methyl radical; and at least one fungicidal compound B. A method for preventing or controlling phytopathogenic fungi on crops by applying an effective and non-plant-poisonous amount of said compound on the exposed parts of the plants is also disclosed.Type: GrantFiled: May 6, 1997Date of Patent: May 25, 1999Assignee: Rhone Poulenc AgrochimieInventor: Marie-Pascale Latorse
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Patent number: 5900254Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.Type: GrantFiled: June 27, 1996Date of Patent: May 4, 1999Assignee: Norian CorporationInventor: Brent R. Constantz
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Patent number: 5863563Abstract: Methods and compositions for the treatment of the symptoms of a patient who has a pulmonary condition associated with an inhibition of surfactant secretion by type II alveolar cells are described. The method of treatment involves causing a patient to inhale an amount of a pH-raising buffer effective to raise the pH of the aqueous fluid in the microenvironment of the type II alveolar cell lumenal surface, thereby inducing an increase in the rate of surfactant secretion by type II alveolar cells.Type: GrantFiled: October 20, 1994Date of Patent: January 26, 1999Assignee: AlphaGene Inc.Inventor: George Scheele
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Patent number: 5853709Abstract: A topically applied shaving composition for use by a human subject suffering from or prone to development of pseudofolliculitis barbae is disclosed. The composition comprises as its active ingredient about 0.01-5% by weight of a bacteriostatic/hemostyptic agent, and an aqueous or water-miscible solvent, a volatile silicone and a thickening agent. A method of removing hair from a hairy skin area of such a subject comprising the application of a topical shaving composition containing about 0.01-5% by weight of a bacteriostatic/hemostyptic agent prior to removal of the hair by shaving, tweezing or waxing, is also disclosed.Type: GrantFiled: December 12, 1996Date of Patent: December 29, 1998Assignee: Johnson Products Co., Inc.Inventors: Isaac Willis, Adu Gyamfi Darkwa, Apolonio L. Villanueva
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Patent number: 5770232Abstract: A method of disinfecting the food contact surfaces of a food packaging machine comprises introducing to the machine an aqueous solution comprising from about 0.1% to about 1% by weight of hydrogen peroxide and from about 0.01% to about 0.1% by weight of sodium acid pyrophosphate. The food contact surfaces are contacted with the solution at a temperature of at least about 70.degree. C. for a time period of at least about 15 minutes.Type: GrantFiled: March 3, 1997Date of Patent: June 23, 1998Assignee: Tetra Laval Holdings & Finance, SAInventors: Charles S. Sizer, Ronald W. Swank
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Patent number: 5733579Abstract: An oral rehydration solution contains indigestible oligosaccharides. Diarrhea related dehydration requires fluid and electrolyte replacement. The primary etiology of antibiotic-associated diarrhea (also known as pseudomembranous colitis) has been recognized as Clostridium difficile. It is believed that the indigenous microflora of a healthy individual suppresses the normally present C. difficile. However, when the indigenous microflora are disrupted (e.g., during antibiotic treatment) overgrowth of C. difficile may occur causing diarrhea and colitis. Treatment of diarrhea related to C. difficile with rehydration therapy and antibiotics has proven effective, but many times relapse occurs. It has been suggested that normalization of the microflora will inhibit C. difficile relapse. Indigestible oligosaccharides have been shown to inhibit C. difficile infection.Type: GrantFiled: April 5, 1995Date of Patent: March 31, 1998Assignee: Abbott LaboratoriesInventors: Bryan Warren Wolf, Keith Allen Garleb, Sheila Martinson Campbell, Jonathan Allan Meulbroek, Keith Brian Wheeler, Joseph Edward Walton
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Patent number: 5698229Abstract: An antimicrobial composition, characterized by containing an inorganic compound on which silver ion is supported and a compound represented by the following formula ?2!: ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group and R.sup.2 is hydrogen or an alkali metal.Type: GrantFiled: June 25, 1993Date of Patent: December 16, 1997Assignee: Toagosei Co., Ltd.Inventors: Shuichi Ohsumi, Hideki Kato
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Patent number: 5688492Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.Type: GrantFiled: July 22, 1996Date of Patent: November 18, 1997Assignee: The Boots Company PLC,Inventors: Edward Galley, Michael David Cooper
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Patent number: 5653973Abstract: Baits useful for controlling lepidoptera populations is made with (a) a diet component for lepidoptera; (b) a toxicant; (c) a chemiluminescent, visual attractant and (d) an encapsulating agent that will allow moisture to permeate and form an external condensate of said diet and said toxicant. The diet, toxicant, and chemiluminescent visual attractant can be used in the same bait particle in a homogeneous or layered structure. Alternatively, the diet/toxicant may be used with a first encapsulating agent in a first bait particle with the chemiluminescent, visual attractant encapsulated in a second bait particle and distributed among the diet/toxicant bait particles.Type: GrantFiled: August 16, 1996Date of Patent: August 5, 1997Assignee: Micro Flo CompanyInventors: Chel W. Lew, Keith Branly, Jesse Gaytan, Osborn Jones Turner
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Patent number: 5626883Abstract: A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be administered to a human to avoid the transitory initial suppression of human NK cell activity which is present when ascorbic acid alone is administered. Also included is xylitol, lysine acetate, tetrasodium pyrophosphate, ribose, cysteine, and hesperidin which further prolongs the biological activity of ascorbic acid and promotes the uptake of ascorbic acid by human tissue.Type: GrantFiled: April 15, 1994Date of Patent: May 6, 1997Assignee: Metagenics, Inc.Inventor: Stephen M. Paul
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Patent number: 5616324Abstract: A synergistic mixture particularly suitable for the treatment of animals whic consists of at least two of the group consisting of DL.Phenylalanine, Ruta Graveolans and Corydali Bulbosa together with a carrier to make up a required volume, the mixture having a pro-inflammatory effect which accelerates the healing process of inflammation. It is preferred that there is provided mixture of DL.Phenylalanine with one product selected from the group of Ruta Graveolans and Corydalis Bulbosa. In a specific form, the mixture also includes Nicotinic Acid.Type: GrantFiled: May 31, 1995Date of Patent: April 1, 1997Inventors: Antoinette Foster, Don Foster
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Patent number: 5616346Abstract: Orally administered colonic purgative formulations and methods of its use for effecting partial or complete purgation of the colon in mammals, the formulations consisting of non-aqueous admixtures of monobasic, dibasic and tribasic sodium phosphates administered in tablet or capsule form in concentrations of from 0.01 to 0.85 grams per kilogram body weight. Preferred embodiments include the addition of binders, dispersants and buffers which do not adversely affect osmolality or effectiveness of the purgative formulations.Type: GrantFiled: June 26, 1996Date of Patent: April 1, 1997Inventor: Craig A. Aronchick
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Patent number: 5599804Abstract: Fungicidal compositions for the protection of turfgrass against crown and root rot are disclosed. The compositions comprise, as the active material, (a) a first active agent selected from the group consisting of (i) a monoester salt of a phosphorous acid (preferably aluminum ethyl phosphite), and (ii) phosphorous acid or an alkali or alkali earth metal salt thereof; and (b) a benzoporphyrin compound. Preferred compositions comprise 1 part by weight of the first active agent, and between about 0.01 and about 0.1 parts by weight of the benzoporphyrin compound.Type: GrantFiled: April 3, 1995Date of Patent: February 4, 1997Assignee: Rhone-Poulenc, Inc.Inventor: Laurence C. Mudge
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Patent number: 5593678Abstract: Utility of protein phosphatase inhibitors to protect teleost fish from microorganismic pathogens is disclosed. The present invention provides pharmaceutical compositions, kits, and methods of therapeutic and prophylactic treatments comprising sodium orthovanadate or vanadate-mimetic protein phosphatase inhibitors to protect fish, for example, catfish, from infection and disease caused by microorganismic pathogens, e.g., Edwardsiella. Sodium orthovanadate, a protein phosphatase inhibitor, and vanadate-mimetic protein phosphatase inhibitors activate in vitro and in vivo the cytotoxicity of teleost nonspecific cytotoxic cells (NCC).Type: GrantFiled: October 11, 1994Date of Patent: January 14, 1997Assignee: University of Georgia Research FoundationInventors: Donald L. Evans, Liliana Jaso-Friedmann
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Patent number: 5490992Abstract: The present invention is generally related to a product and a process to reduce the microbial contamination of processed meat and is particularly related to a product and a process to disinfect poultry carcasses using a disinfectant composition containing a fatty acid monoester, an acid or chelating agent, and a food grade surfactant. These components may be combined in either an aqueous or nonaqueous vehicle as desired. The present combination is effective against pathogenic and undesired bacteria. Advantageously, the present composition does not detrimentally alter the taste, texture, color, odor or appearance of the processed meat.Type: GrantFiled: March 22, 1995Date of Patent: February 13, 1996Assignee: Minnesota Mining and Manufacturing CompanyInventors: Jeffrey F. Andrews, Janet F. Munson
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Patent number: 5460833Abstract: The present invention is generally related to a product and a process to reduce the microbial contamination of processed meat and is particularly related to a product and a process to disinfect poultry carcasses using a disinfectant composition containing a fatty acid monoester, an acid or chelating agent, and a food grade surfactant. These components may be combined in either an aqueous or nonaqueous vehicle as desired. The present combination is effective against pathogenic and undesired bacteria. Advantageously, the present composition does not detrimentally alter the taste, texture, color, odor or appearance of the processed meat.Type: GrantFiled: March 22, 1995Date of Patent: October 24, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Jeffrey F. Andrews, Janet F. Munson
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Patent number: 5459030Abstract: Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.Type: GrantFiled: June 2, 1993Date of Patent: October 17, 1995Assignee: Steritech, Inc.Inventors: Lily Lin, Laurence Corash
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Patent number: 5403597Abstract: A method for fumigating an enclosed structure includes release of sufficient phosphine into the enclosed structure to maintain an average concentration of between about 50 ppm and 500 ppm phosphine. Concurrently, sufficient carbon dioxide is released into the enclosed structure to maintain an average concentration of between about 4% and 10% carbon dioxide, and a temperature of between about 30 degrees Celsius to about 40 degrees Celsius is maintained in the enclosed structure to enhance fumigation effectiveness.Type: GrantFiled: November 22, 1993Date of Patent: April 4, 1995Inventor: David K. Mueller
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Patent number: 5360782Abstract: Aqueous thiocarbonate solutions are stabilized by the addition of base, sulfide and/or polysulfide, and the stability and safety of the more concentrated solutions containing 1 weight percent or more equivalent CS.sub.2 as a thiocarbonate are achieved as reflected by significant reduction of CS.sub.2 partial pressure in such solutions. Also, deposit formation in irrigation systems delivering such thiocarbonates, such as drip emitters and sprinkler heads, is reduced or eliminated with minor amounts of sodium hexametaphosphate.Type: GrantFiled: October 22, 1993Date of Patent: November 1, 1994Assignee: Union Oil Company of CaliforniaInventors: Donald C. Young, James A. Green, II
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Patent number: 5354565Abstract: A biocide composition comprising(A) 1 to 50% by weight of a biocide, and(B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.Type: GrantFiled: April 15, 1992Date of Patent: October 11, 1994Assignee: Kao CorporationInventors: Tetsuji Iwasaki, Tadashi Moriyama, Yuichi Hioki
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Patent number: 5332580Abstract: Aqueous thiocarbonate solutions are stabilized by the addition of base, sulfide and/or polysulfide, and the stability and safety of the more concentrated solutions containing 1 weight percent or more equivalent CS.sub.2 as a thiocarbonate are achieved as reflected by significant reduction of CS.sub.2 partial pressure in such solutions. Also, deposit formation in irrigation systems delivering such thiocarbonates, such as drip emitters and sprinkler heads, is reduced or eliminated with minor amounts of sodium hexametaphosphate.Type: GrantFiled: November 25, 1992Date of Patent: July 26, 1994Assignee: Union Oil Company of CaliforniaInventors: Donald C. Young, James A. Green, II
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Patent number: 5324751Abstract: Free-flowing formations of spherules of loose knit microcrystals of the polymorphs of sorbitol and mannitol are useful in fast-frozen food products as cryoprotectants due to their improved rate of solubility and dispersion. The free-flowing formations are also helpful in formulating confectionary and pharmaceutical products by improving processing efficiencies and texture and are useful in selected industrial applications as a result of their improved rate of solution and free-flowing characteristics.Type: GrantFiled: March 12, 1993Date of Patent: June 28, 1994Assignee: ICI Americas Inc.Inventor: James W. DuRoss
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Patent number: 5304724Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the bicarbonate and glutathione are freeze-dried, packaged and separately stored in lyophilized powder form until just preceding the operation, at which time the lyophilized powder containing the bicarbonate and glutathione is dissolved directly into a conventional I.V. solution.Type: GrantFiled: February 19, 1992Date of Patent: April 19, 1994Assignee: Entravision, Inc.Inventor: Walter A. Newton
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Patent number: 5296238Abstract: The present invention provides a microbicide which comprises a phosphate represented by the following general formula:M.sub.a.sup.1 A.sub.b M.sub.c.sup.2 (PO.sub.4).sub.d.nH.sub.2 Owherein M.sup.1 represents at least one element selected from the group consisting of silver, copper, zinc, tin, mercury, lead, iron, cobalt, nickel, manganese, arsenic, antimony, bismuth, barium, cadmium and chromium, M.sup.2 represents at least one element selected from tetravelent metal elements, A represents at least one ion selected from the group consisting of hydrogen ion, alkali metal ions, alkaline earth metal ions and ammonium ion, n represents a number which satisfies 0.ltoreq.n.ltoreq.6, a and b each represents a positive number and satisfy la+mb=1 or la+mb=2, and when a and b satisfy la+mb=1, c is 2 and d is 3, and when a and b satisfy la+mb=2, c is 1 and d is 2, where 1 is valence of M.sup.1 and m is valence of A.Type: GrantFiled: February 26, 1991Date of Patent: March 22, 1994Assignee: Toagosei Chemical Industry Co., Inc.Inventors: Koji Sugiura, Satoru Maekawa, Hidemu Inoue, Takuya Oomura, Hideki Kato, Hiroki Kourai
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Patent number: 5186947Abstract: Water-soluble wood preservatives which contain mixtures of a metal compound, a metal-fixing acid and a complexing polymeric nitrogen compound, and methods for protecting wood with such mixtures.Type: GrantFiled: September 19, 1991Date of Patent: February 16, 1993Assignee: Dr. Wolman GmbHInventors: Reimer Goettsche, Wolfgang Reuther
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Patent number: 5128151Abstract: Powdered and/or granulated menadione sodium bisulfite formulations additionally contain a physiologically tolerated organic or inorganic acid.The novel formulations possess good water solubility and stability.Type: GrantFiled: January 7, 1988Date of Patent: July 7, 1992Assignee: Basf AktiengesellschaftInventors: Hans Kiefer, Wolfgang Buehler, Joachim U. Schneider, Hagen Jaedicke
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Patent number: 5104663Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the chloride salts (Ringer solution) are packaged and stored in solution and the bicarbonate and glutathione are freeze-dried and packaged and separately stored in powder form until immediately preceeding the operation, at which time the bicarbonate and glutathione are dissolved directly into the solution of chloride salts. The resulting solution is mixed within 24 hours of use.Type: GrantFiled: September 4, 1990Date of Patent: April 14, 1992Assignee: Entravision, Inc.Inventors: Walter A. Newton, Douglas V. Carter
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Patent number: 5089477Abstract: Disclosed here are novel compositions and methods which can be used to reduce or prevent adverse physiological effects of physical exercise or environmental exposure. The novel compositions comprise fluids containing water, sugar, electrolytes, and a substance which is non-toxic to man or animals, can be rapidly absorbed through the gastrointestinal tract, prevents decreases in blood volume, and acts as an energy source.Type: GrantFiled: October 29, 1990Date of Patent: February 18, 1992Assignee: University of FloridaInventors: Melvin J. Fregly, R. Malcolm Privette, Robert Cade
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Patent number: 5073383Abstract: Aggregation of fluorocarbon emulsion particles, which occurs when the emulsion mixes with blood, is reduced by the addition of relatively large amounts of phosphate.Type: GrantFiled: April 21, 1989Date of Patent: December 17, 1991Assignee: Affinity Biotech, Inc.Inventor: Robert T. Lyons
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Patent number: 5071655Abstract: A pharmaceutical composition for increasing bone mass and preventing loss of bone mass is provided, comprising a fluoride source and a mitogenic hydantoin in combination with a pharmaceutically acceptable carrier, in which the fluoride source provides a molar ratio of fluoride ion to hydantoin in the composition of from about 0.1:1 to about 100:1. The combination is administered to a vertebrate, typically in the form of an orally administratable tablet or capsule.Type: GrantFiled: January 12, 1990Date of Patent: December 10, 1991Inventor: David J. Baylink
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Patent number: 5034383Abstract: Bacterial endotoxins are inhibited by a non-toxic, water-soluble, pharmaceutically acceptable peroxydiphosphate compound in contact with bacterial endotoxin.Type: GrantFiled: March 13, 1989Date of Patent: July 23, 1991Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, Edward J. Coleman
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Patent number: 4975423Abstract: Non-toxic water-soluble pharmaceutically acceptable compound derivative of peroxydiphosphoric acid when administered orally or systemically supplements inhibition of malignant myeloma carcinoma tumor development of tumor cells in vitro and actual tumor development in vivo in warm blooded animals.Type: GrantFiled: May 3, 1989Date of Patent: December 4, 1990Assignee: Colgate-Palmolive CompanyInventor: Abdul Gaffar
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Patent number: 4965072Abstract: The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.Type: GrantFiled: November 3, 1988Date of Patent: October 23, 1990Assignee: Miles Inc.Inventors: Thomas A. Alexander, Lawrence J. Daher, Clarence L. Hancock, Donald L. Peterson
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Patent number: 4938961Abstract: An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, in aqueous solution, at least about 3% by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.Type: GrantFiled: April 28, 1989Date of Patent: July 3, 1990Inventors: Geoffrey Collins, Winston Wicomb
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Patent number: 4911931Abstract: A pharmaceutical composition for increasing bone mass and preventing loss of bone mass is provided, comprising a fluoride source and a mitogenic hydantoin in combination with a pharmaceutically acceptable carrier. The combination is administered to a vertebrate, typically in the form of an orally administratable tablet or capsule.Type: GrantFiled: August 3, 1987Date of Patent: March 27, 1990Inventor: David J. Baylink
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Patent number: 4908211Abstract: Chewing gum or a chewable confection including either sanguinarine, benzophenanthridine alkaloid, or soluble poly-pyrophosphates, or both to chemically inhibit the formation of plaque and calculus.Type: GrantFiled: June 9, 1988Date of Patent: March 13, 1990Inventor: Armando F. Paz
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Patent number: 4861590Abstract: A slow release tablet or the like for releasing fluoride and calcium ions in a manner so as to reduce the formation of calcium fluoride and to reduce gastrointestinal discomfort comprising the use of MFP together with a calcium-containing composition.Type: GrantFiled: September 25, 1986Date of Patent: August 29, 1989Assignee: Colgate-Palmolive CompanyInventor: Marcus G. Grodberg
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Patent number: 4859467Abstract: A medication for providing fluoride ion for the prevention and treatment of bone loss disease. The dosage is a lozenge, tablet or capsule containing from 20 to 100 milligrams of sodium monofluorophosphate and further includes a slow release mechanism for controlling release of the fluoride ion over a period of up to eight hours after swallowing. Up to ten percent of sodium fluoride can be added.Type: GrantFiled: September 25, 1986Date of Patent: August 22, 1989Assignee: Colgate-Palmotive CompanyInventors: Marcus G. Grodberg, David J. Baylink
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Patent number: 4849219Abstract: A microbicidal composition comprising at least one microbicidal acylaniline derivative such as metalaxyl, furalaxyl and the like, and H.sub.3 PO.sub.3 or a salt thereof, exerts a synergistically potentiated activity against plant diseases, especially also against acylaniline-resistant pathogens. The composition may optionally comprise a third protective fungicidal component. The three active components may be applied in succession in any order or simultaneously.Type: GrantFiled: April 27, 1988Date of Patent: July 18, 1989Assignee: Ciba-Geigy CorporationInventors: Theodor Staub, Robert J. Williams, Paul Margot