Abstract: It is an object of the invention to provide a simple disinfecting method for assuring an excellent disinfecting effect. The present method uses a disinfecting liquid in which a hydrogen peroxide is included in an aqueous medium. The disinfecting liquid is accommodated in a suitable container such that the disinfecting liquid accommodated in the container has a depth of 3-10 mm, and the disinfecting liquid in which an object to be disinfected is immersed is irradiated with a light having a wavelength of 280-385 nm, such that the light is incident on the disinfecting liquid at least in a direction of the depth of the disinfecting liquid, so that the object immersed in the disinfecting liquid is disinfected.

Abstract: The present invention is directed to frozen biocidal compositions. Specifically, the biocidal compositions comprise a frozen aqueous solution of a plurality of ions selected from the group consisting of halide and oxyhalide ions. The frozen biocidal compositions are useful in preserving or extending the shelf-life of perishable articles.

Abstract: The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimithyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone.

Abstract: A beneficial material for medical application in association with a substrate comprises a support material and a reactive material. The reactive material is ion exchanged into the support material. The medical application may comprise a wound healing device, insect control adhesives and anti-microbial creams. The invention further discloses other beneficial materials, such as ionically conductive compounds, photoactive compounds and materials for medical application and methods of formulating same.

Abstract: A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood material with an iron salt and selected oxidants where the iron salt is preferably complexed with organic chelating ligands. Preferably, a microbicidal agent is also incorporated into the method to provide treated wood products that demonstrate excellent surface integrity, dimensional stability and retention of the infused microbicidal agents for extended periods of time without incurring the detrimental environmental effects of conventional chromium or copper-based inorganic salt preservation methods.

Abstract: This invention relates to methods of increasing the efficacy of peroxides such as benzoyl peroxide in the treatment of skin conditions such as acne. In a preferred embodiment, the invention relates to methods of increasing radicals formed by peroxides on/in the skin, more specifically near/in the comedone, for topical use in dermatology. In a specific embodiment, the invention relates to the use of transitional metals such as Cu(1) and ferrous ions-to increase the efficacy of peroxides such as benzoyl peroxide. In another embodiment, the invention relates to a method by which a peroxide such as benzoyl peroxide and its activator are added to the skin surface at the same time. In another embodiment, the invention relates to the use of a more soluble form of peroxide such as benzoyl peroxide to increase its efficacy. In another embodiment, the invention relates to the addition of a side chain to a peroxide such as benzoyl peroxide so that it is activated by light.

Abstract: A new, novel and useful disinfection and purification system comprised of organic compounds in synergistic action with selected metal ions and method of manufacture and use. One of the benefits that is derived from this system is the ability to quickly and easily treat a surface, fluid or medium for disinfection of bacteria, fungi, viruses, algae and protozoans, with a non-toxic, non-chlorinated mixture that effectively kills all such organisms in minutes or hours. The disinfection and purification system remains effective for long periods of time maintaining its disinfection capacity making it highly effective for stored or transported mediums such as potable drinking water. The disinfection and purification system may be incorporated with carbon block or membrane filters to disinfect filtered liquids such as water to render it potable.

Abstract: The present invention is a method of stabilizing hydrogen peroxide in an aqueous solution, such as a circulating water slurry, comprising a peroxide, such as hydrogen peroxide. The aqueous solution may include organic matter. The method comprises adding an aldehyde donor, such as a methylolhydantoin, to the solution (or slurry). The inventors have discovered that aldehyde donors significantly reduce the decomposition of hydrogen peroxide by catalase and other peroxide decomposing enzymes, which are often present in recycled paper. As a result, less hydrogen peroxide needs to be added to a solution to effectively bleach organic matter in the solution. Furthermore, aldehyde donors are safe to handle and cost effective. Another embodiment is a method of bleaching recycled papers in a circulating water slurry comprising organic matter. The method comprises adding hydrogen peroxide and an aldehyde donor to the slurry.

Abstract: Vasospastic disorders are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's blood stream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers, along with an enhancement of endothelial function in the patient.

Abstract: A novel composition has been discovered for decontaminating biofilm-contaminated surfaces (the “Biocidal Complex”). The novel composition both kills bacteria and destroys at least a part of the biofilm. The composition comprises an effective amount of a free-radical generating compound (e.g., hydrogen peroxide), a disinfectant from the “GRAS” list of food-safe compounds (e.g., thymol), and an acid sulfate such as sodium bisulfate (NaHSO4) to acidify the solution and help catalyze free radical formation. A preferred method of using this invention employs a multi-component approach that permits long-term storage of the components in a stable, concentrated form. Immediately before use, the components are mixed and then applied to the biofilm-contaminated surface. A separate metal catalyst for the generation of free-radicals may be added to increase the production of free radicals in the Biocidal Complex.

Abstract: This invention relates to a composition and method for the treatment of white line disease, including ailments such as Onychomycosis, sporotichosis, hoof rot, jungle rot, pseudallecheria boydii, scopulariopsis or athletes foot. The composition of the present invention is useful for the treatment of fungal infections such as Onychomycosis in warm blooded animals such as humans and horses. The method of the present invention is directed to the application of a therapeutic amount of the present composition.

Abstract: A method of treating or preventing atherosclerosis in a mammalian subject comprises: (a) extracting the aliquot of blood from the subject; (b) treating the aliquot of blood ex vivo with at least one stressor selected from the group consisting of an oxidizing agent, ultraviolet radiation and elevated temperature; and (c) administering the aliquot of blood treated in step (b) to the subject. Preferably, the aliquot has a volume of from about 0.01 ml to about 400 ml and is treated simultaneously by ozone gas and ultraviolet radiation at a temperature of from 37-55° C.

Abstract: Skin-growth-enhancing compounds and compositions including a therapeutically effective amount of at least one electron active compound, or a pharmaceutically acceptable derivative thereof, that has at least two polyvalent cations, at least one of which has a first valence state and at least one of which has a second, different valence state. Preferred compounds include Bi(III,V) oxide, Co(II,III) oxide, Cu(I,III) oxide, Fe(II,III) oxide, Mn(II,III) oxide, and Pr(III,IV) oxide, and Ag(I,III) oxide, or a combination thereof. These compounds may be in a crystalline state having metallic cations of two different valences, or electronic states, in the inorganic crystal. Also included are articles containing such compositions, such as wound dressings, and methods for facilitating or enhancing skin growth using these compounds, compositions, and articles, such as for the treatment or management of burns or skin grafts.

Abstract: The present invention relates to a biocidal composition, designed for the generation of chlorine dioxide, comprising at least one iodo-compound having at least one iodine atom and a source of chlorite ions. The molar ration of chlorite ions to iodine atoms is 2 or greater. The composition finds use in a variety of applications including methods of cleaning, sanitizing, deodorizing, and disinfecting various surfaces.

Abstract: An aqueous acidic lubricating composition for use in the mucosal areas of the human body, that provides at least 30 ppm of available iodine. There is also provided a method of treating vaginitis preventing STD and group B streptococcus.

Abstract: A process for controlling a wide variety of simple celled pests by applications of various formulations using sodium peroxyhydrate as a principal active ingredient. Some forms of the pesticide further include at least one other less reactive material which may be selected from the group consisting of lime (calcium oxide), gypsum, clay calcium nitrate, urea, calcium nitrate tetrahydrate, ammonium nitrate, monocalcium phosphate, dicalcium phosphate, ammonium phosphate, a fertilizer, a form phosphate, and epsom salt. In some embodiments of the invention the pesticide includes a material selected to control the pH at the area of application and thereby constrain the development of microorganisms. The invention also includes the process for controlling microorganisms on turf which comprises applying sodium percarbonate and irrigating the turf. The sodium percarbonate may be utilized in either a solid form or may be in solution.

Abstract: Decontamination of biological spores occurs by applying a germination solution for spores containing calcium ions, preferably calcium chloride, and dipicolinic acid in combination with a decontaminant. The germination composition may include water and a surfactant. The germination solution allows for lower concentrations of select decontaminants to be effectively used against spore contamination. The germination composition may be applied prior to, concurrently, or sequentially with repeated applications of the decontaminant.

Abstract: In producing aqueous microbiocidal solutions by oxidation of a water-soluble alkali metal bromide, an intolerable loss of active halogen species has been found to occur during a 10-day period immediately after the product solution has been formed. Surprisingly, this loss has been found to result from an alcohol impurity in the alkali metal bromide used in the process. By eliminating or at least sharply reducing the amount of alcohol impurity in the reaction mixture, products are formed which do not undergo the intolerable loss of active halogen content during the 10-day period.

Abstract: Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise in homogeneous dispersion very small amounts of heavy metals which are physiologically tolerated in these amounts, or very small amounts of peroxide-cleaving enzymes.

Abstract: A non-corrosive, liquid, aqueous sterilant composition (as a concentrate or ready-to-use solution), which may be provided in two parts which are mixed prior to application, may comprise a peracid (in an equilibrium solution with an underlying carboxylic acid or mixtures of alkyl carboxylic acids and peroxide), inorganic buffering agent, and water. It has been found that the use of this simplified system, even in the absence of additional components which have been thought to be desirable for sterilants used on metal parts (e.g.

Abstract: Disclosed is a dermal barrier composition which contains a hydrophilic polymer emulsion and a hydrophobic polymer emulsion. The dermal barrier composition is moisture activated, and remains inert until the hydrophobic and hydrophilic polymer emulsions contact a suitable substrate such as human skin. The dermal barrier composition is itself an emulsion, and can optionally contain a biocidal agent for antimicrobial and antiviral efficacy. The dermal barrier composition can also contain other active agents such as sunscreens, insect repellents and fungicides. The dermal barrier composition can be applied topically to skin, where it forms a protective or barrier layer against a number of pathogenic and chemical irritants.

Abstract: The present invention relates to a product comprising tooth whitening substance which comprises a high concentration of water, a peroxide, a gelling agent, and carrier materials. The tooth whitening substance will remain stable when stored as a thin layer. The present invention also relates to a method of storage of a tooth whitening substance and a method producing a stable thin layer of tooth whitening substance on a strip of material. Additionally, the present invention relates to the benefits obtained from the tooth whitening composition.

Abstract: Oral care compositions comprising chlorine dioxide and excipients, including flavoring agents and ethoxylated hydrogenated castor oil having ethoxylation numbers from about 35 to about 60. The flavoring agents become bound to the hydrophobic end of the ethoxylated hydrogenated castor oil molecule and become encapsulated within the molecule as the hydrophilic end of the ethoxylated hydrogenated castor oil wraps around the flavoring agent. The flavoring agent does not undergo oxidation. The oral care compositions do not develop either a chlorine odor or yellowing discoloration. The oral care compositions can be packaged, stored, sold and used in a single package.

Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.

Abstract: A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity. A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment.

Abstract: A method of treating congestive heart failure (CHF) in a human patient comprises treating an aliquot of the patient's blood ex vivo with at least one stressor selected from the group consisting of a temperature above or below body temperature, an electromagnetic emission and an oxidative environment, followed by administering the aliquot of treated blood to the patient. The treatment can be used on its own or as an adjunctive therapy in combination with conventional CHF treatments.

Abstract: A method for treating hair, combining permanent dyeing and straightening of hair, without significantly damaging the hair. According to the method of the present invention the hair is treated by chemically reducing covalent disulfide linkages in the hair, and contacting said hair with at least one oxidoreductase, at least one mediator, and at least one chemical oxidizing agent in an amount equivalent to 0.001-1% hydrogen peroxide calculated by weight of the dyeing formulation.

Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.

Abstract: An aqueous gel useful for bleaching teeth comprising: (i) water; (ii) polyacrylic acid thickening agent; (iii) hydrogen peroxide bleaching agent; and (iv) aminocarboxylic acid/salt stabilizing agent. Preferably the polyacrylic acid is an easy to disperse carbomer and the gels contain high concentrations (20 to 40% by weight) of hydrogen peroxide. The gels exhibit room temperature stability, both with respect to gel stability and hydrogen peroxide decomposition, sufficient to eliminate the need for constant refrigeration. A method for using the gels to bleach teeth is also disclosed.

Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.

Abstract: A beneficial material for medical application in association with a substrate comprises a support material and a reactive material. The reactive material is ion exchanged into the support material. The medical application may comprise a wound healing device, insect control adhesives and anti-microbial creams. The invention further discloses other beneficial materials, such as ionically conductive compounds, photoactive compounds and materials for medical application and methods of formulating same.

Abstract: A method of controlling target aquatic microorganism pest populations by exposing the target population to an effective amount of an aquacidal compound. The aquacidal compounds are selected from the group consisting of quinones, anthraquinones, naphthalenediones, quinine, warfarin, coumarins, amphotalide, cyclohexadiene-1,4-dione, phenidione, pirdone, sodium rhodizonate, apirulosin and thymoquinone. The method is particularly effective for treating ballast water of ships or other enclosed volumes of water subject to transport between or among geographic areas to control the relocation of plants, toxic bacteria, and animals contained in the water.

Abstract: The present invention provides a virucide composition and/or sporicide composition having a high virucidal effect and sporicidal effect and being excellent in safety and workability. That is, the present invention provides a virucide composition and/or sporicide composition comprising (a) an inorganic peroxide, (b) tetraacetylethylenediamine and (c) at least one selected from a salt of an alkaline metal salt with an inorganic acid and a salt of an alkaline earth metal with an inorganic acid in a specific ratio.

Abstract: An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or powdered media. The oxidizing species can be used to reduce microbial and viral populations on a surface or object or in a body or stream of water. The invention thus finds applications as a bleach, sanitizer, oxidant, or in any other application in which an oxidizing agent can be beneficially used alone or in a formulation.

Abstract: A dental bleach that includes a bleaching agent and a thickening agent. The bleaching agent is typically a peroxide and the thickening agent is polyvinylpyrrolidone. A viscous or sticky dental bleach results. Optionally, a basic agent, light or heat may be added to accelerate bleaching. Bleaching may take place with the use of a dental tray. Bleach may be placed into the dental tray from a single barrel, double barrel or multi-barrel syringe containing the components of the bleach. Bleach may be placed against a flexible strip which is placed onto teeth to be bleached.

Abstract: The present invention relates to a volatile, residue free peroxide antimicrobial composition, which can be applied as a penetrating and durable, fine aerosol, that has superior strength with respect to decontaminating buildings infected with bacteria, fungi, virus or fungal or bacterial spores. The present invention is also directed to a process for decontaminating large man made structures and the air contained in these.

Abstract: Described herein is a novel high efficiency teeth bleaching system based on thesynergetic action of the combination of hydrogen peroxide (in a free form or in the form of its adduct with urea) and peroxide and/or percarbonates of metals belonging to the first or second group of the periodic table. In one embodiment, the system of the preferred embodiment comprises two components, one containing hydrogen peroxide or carbamide peroxide (hydrogen peroxide/urea adduct), and the other containing metal peroxides and/or percarbonates. Mixing of the two components results in the accelerated generation of radical oxygen, which relates to faster teeth bleaching action.

Abstract: Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination with a peroxy compound (e.g., hydrogen peroxide), and methods for using such preparations for disinfection of articles or surfaces (e.g., contact lenses, counter tops, etc.), antisepsis of skin or other body parts, prevention or deterrence of scar formation and/or treatment and prophylaxis of dermal (i.e., skin or mucous membrane) disorders (e.g., wounds, burns, infections, cold sores, ulcerations, psoriasis, acne, or other scar-forming lesions).

Abstract: Vasospastic disorders such as Raynaud's phenomenon are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's bloodstream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers along with an enhancement of endothelial function in the patient.

Abstract: A substantially anhydrous gel useful for bleaching teeth comprising: (i) at least 25% by weight of organic polyol; (ii) less than 3% by weight polyacrylic acid thickening agent; (iii) at least 10% by weight carbamide peroxide (or a chemically equivalent amount of another bleaching agent, such as 3% by weight hydrogen peroxide); (iv) neutralizing agent; (v) chelating agents; (vi) desensitizing agent; and (vii) miscellaneous ingredients such as Cirtoxain® and flavorants. The organic polyol is preferably glycerin. The polyacrylic acid thickening agent is preferably a carbomer. The desensitizing agent is preferably potassium nitrate, strontium chloride, potassium citrate, strontium nitrate, or a similarly effective alkali or alkaline earth metal salt of an organic or inorganic acid.

Abstract: A physiologically-balanced, ionized, acidic solution. The solution may be prepared by the electrolysis of a solution comprising a mixture of inorganic salts in physiologically balanced proportions. A mixture of inorganic salts and, optionally, minerals (such as metallic elements, for example, and not by way of limitation) is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises halide salts of sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide; and most typically chloride. The halide-comprising acidic solution is physiologically balanced by the inclusion of elements such as sodium, potassium, magnesium, zinc, lithium, and beryllium in the solution. The composition of the invention is nontoxic and has antibacterial properties.

Abstract: Methods of treating tumors, lesions, and cancers comprising delivering to the affected site a combination of peroxide and hypochlorite anion. Hydrogen peroxide and sodium hypochlorite are possible sources of peroxide and hypochlorite anion, respectively. The reactants may be injected simultaneously or sequentially, and combine at the site to produce singlet oxygen. Singlet oxygen may be delivered to the treatment site or generated at the treatment site.

Abstract: Compositions and methods are provided for inhibiting skin irritation attributable to chemical irritants, including skin exfoliant irritants, and environmental conditions by the application of an anti-irritant amount of aqueous-soluble divalent calcium cation.

Abstract: A method of treating or preventing atherosclerosis in a mammalian subject comprises: (a) extracting the aliquot of blood from the subject; (b) treating the aliquot of blood ex vivo with at least one stressor selected from the group consisting of an oxidizing agent, ultraviolet radiation and elevated temperature; and (c) administering the aliquot of blood treated in step (b) to the subject. Preferably, the aliquot has a volume of from about 0.01 ml to about 400 ml and is treated simultaneously by ozone gas and ultraviolet radiation at a temperature of from 37-55° C.

Abstract: The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable Eh raising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the Eh of the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

Abstract: A process and composition for bleaching teeth made up of two formulations blended together before each application. The invention offers faster results while significantly reducing the possibility of user discomfort. One of said formulations contains hydrogen peroxide (in a free form or in the form of an adduct), the other contains salts and hydroxides and/or oxides of metals belonging to the first or second group of the Periodic Table which stimulate the generation of radical oxygen. The invention allows for balancing pH and assuring adequate water concentration to avoid tissue desiccation and user discomfort without compromising shelf life of the device.

Abstract: A food composition containing a food product, fish oil, and a fish oil stabilizing agent. The fish oil is a nonhydrogenated fish oil containing omega-3 long chain fatty acids that has been deodorized and refined for packaging. The stabilizing agent consists of the citrus flavonoid naringin that is derived from the pulp and peel of grapefruit. The stabilizing agent comprises between about 0.003 weight percent of the food composition to about 0.02 weight percent of the food composition. The stabilizing agent protects the fish oil from taste and odor degradation, and allows for long term storage of the food composition containing the fish oil.

Abstract: A topical virucidal pharmaceutical formulation comprising as active ingredient an inorganic halide, an oxidizing agent capable of generating hypohalite ions in aqueous solution, a sulphamic acid, a non-reducing organic acid and an inorganic phosphate optionally with a surfactant, preferably an anionic surfactant, together with one or more pharmaceutically acceptable excipients.

Abstract: The invention relates to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist in a cosmetic, pharmaceutical or dermatological composition for treating sensitive skins. It relates especially to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist for preventing and/or combating skin irritations and/or sores and/or erythema and/or dysaesthesic sensations and/or sensations of inflammation and/or pruritus and/or prickling and/or tingling and/or discomfort and/or tightness of the skin and/or mucosae. It also relates to a composition containing a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist which limits or eliminates the irritant side-effects of certain products, and in particular of certain cosmetic, dermatological or pharmaceutical active agents.

Abstract: An injectable physiologically acceptable aqueous phase fluorocarbon emulsion, which has substantially no free fluorocarbon, has an excellent stability is prepared by a process of the invention. Typically, more than about 99.8 wt. % of the fluorocarbon remains in the size range of about 0.2 to 0.4 microns even after being stored at room temperature for one year or more in sealed containers under a non-oxidizing atmosphere. The emulsion is useful in medical applications, for example, coronary angioplasty, cancer therapy, among others.