Abstract: Stable oxidizing bromine compounds are prepared by preparing a caustic solution comprising a halogen stabilizer, water and an alkali or alkaline earth metal hydroxide, the halogen stabilizer being selected from the group consisting of R—NH2, R—NH—R1, R—SO2—NH2, R—SO2—NHR1, R—CO—NH2, R—CO—NH—R1 and R—CO—NH—CO—R1 wherein R is a hydroxy group, an alkyl group or an aromatic group and R1 is an alkyl group or an aromatic group, adding bromine chloride to the solution while mixing the solution, and cooling the solution.

Abstract: A process for preventing the transfer of harmful organisms of zooplankton including the epifauna thereof and of phytoplankton including its resting stages, which are taken up with the ballast water of ships and transferred to another locality on discharge. The organisms are substantially destroyed by the addition of an agent containing a water-soluble percarboxylic acid with 1 to 6 carbon atoms, particularly an aqueous solution containing peracetic acid and/or performic acid and hydrogen peroxide, in a quantity of 0.1 to 200 mg of percarboxylic acid per liter of ballast water and allowing it to react before discharge. In a preferred embodiment, cyanide is also added to the ballast water.

Abstract: This invention provides a liquid antimicrobial composition that is particularly useful as a mouthwash for treating or reducing the risk of dental disease. The composition is prepared by mixing a first solution comprising a water soluble metal chlorite compound with a second solution comprising sodium persulfate and hydrogen peroxide. The resulting composition, containing chlorine dioxide, is preferably used at the time of preparation by applying the composition to the locus where treatment is desired.

Abstract: The present invention relates to an aqueous decontaminating composition comprising (A) an amount of H2O2 less than or equal to 60% by weight, based on the total weight of said composition; (B) an RCO3H/RCO2H mixture, where R is methyl or ethyl, as indicated above, said mixture being present in an amount such that the weight ratio of said mixture to the hydrogen peroxide is between 0.15/1 and 0.85/1; (C) a silver component as a source of Ag ions, selected from the group consisting of silver salts and complexes, said silver component being present in an amount such that the weight ratio of said silver component to the hydrogen peroxide is between 0.0005/1 and 0.015/1; (D) a stabilizer present in an amount such that the weight ratio of said stabilizer to the hydrogen peroxide is between 0.0005/1 and 0.025/1; and water to make up to 100% by weight. It further relates to the method of preparation and to the use of said composition.

Abstract: An enzymatic antimicrobial composition comprising a haloperoxidase, a hydrogen peroxide source, a halide source, and an ammonium source, in particular an ammonium salt or an aminoalcohol, in which there is a hitherto unknown synergistic effect between the halide and the ammonium source.

Abstract: The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, extracorporeally, to oxidative stress, in appropriate dosage amounts, such as bubbling a gaseous mixture of ozone and oxygen through a suspension of the T-cells. The process may also include irradiation of the cells with UV light, simultaneously with the application of the oxidative stress. The oxidative stress induces reduced inflammatory cytokine production and a reduced proliferative response in the T-cells.

Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.

Abstract: A developer composition having a pH of 2.5 to 6.9, for use in oxidative dyeing of hair comprising 0.01-20% of a primary thickening agent which is an aqueous solution of acrylic polymer comprised of A and B monomers wherein the A monomer is selected from the group consisting of acrylic acid, methacrylic acid, and mixtures thereof; and the B monomer is selected from the group consisting of a C1-22 alkyl methacrylate, and a C1-22 alkyl acrylate, and mixtures thereof; 0.01-20% of a nonionic surfactant, 0.01-25% hydrogen peroxide, and 65-99.9% water; a hair dye mixture for coloring hair; a two component kit for coloring hair; and a method for coloring hair.

Abstract: Methods for controlling cell death when the cell is exposed to one or more potentially lethal cellular insults. In one method, cell death is inhibited by introducing a reactive oxygen species limiter into the cell which prevents the build up of lethal levels of reactive oxygen species when the cell is exposed to a cellular insult. In another method, cell death is promoted in cancer cells or other proliferating cells which are naturally resistant to lethal cellular insults. The method involves neutralizing reactive oxygen species limiters, such as bcl-2, which occur naturally in cancer cells and which prevent the build up of reactive oxygen species within the cancer cells when they are exposed to lethal cellular insult. Neutralizing the reactive oxygen species limiter leaves the cancer cell unable to protect itself when cellular insult causes increases in the level of reactive oxygen species. The result is an increase in cell death.

Abstract: Stable microbicidal compositions containing a 3-isothiazolone compound, organic oxidants, copper salts and water are disclosed. Also disclosed are methods of stabilizing 3-isothiazolone compositions.

Abstract: A treatment for xerostomia, employing a composition having the active ingredient of carbamide peroxide. The carbamide peroxide compound contains urea and hydrogen peroxide. The hydrogen peroxide remains stable until the carbamide peroxide is applied to the mouth and contacts the water inherent therein. On contact, the hydrogen peroxide is freed from the urea, allowing the hydrogen peroxide to react within the mouth. The resulting chemical and mechanical reaction stimulates saliva within the mouth and thereby relieves the symptoms of xerostomia.

Abstract: There is described a foamable formulation comprising a foamable carrier and an active ingredient which may be admixed with the carrier or packaged separately and dispersed into the carrier during the foaming process. Alginate gel is a preferred foamable carrier. The foam produced from such a formulation, and a foam sheet produced by drying the foam, also form part of the invention. The formulation, foam and foam sheet are especially useful for medical applications, for example in treating burns. As apparatus to store the components of the formulation and to generate the foam is also described.

Abstract: A method is disclosed for effecting heightened whitening of teeth wherein there is first applied to the teeth an aqueous rinse composition having an alkaline pH and thereafter brushing the teeth with a peroxide dentifrice.

Abstract: An asepsis disinfectant composition in liquid form having germicidal and biofilm cleansing properties comprising an anti-infective, an antiseptic agent, and an anti-biofilm agent for killing pathogenic and non-pathogenic organisms being in the range of 13.0% to 45.5% by weight of the disinfectant composition; a water purifying agent for acting as a detergent, a sanitizer and a bactericide being in the range of 4.0% to 14.0% by weight of the disinfectant composition; a cleansing agent for acting as an astringent and an abradant in the removal of biofilm from contaminated surfaces, and as a bactericide and fungicide being in the range of 10.0% to 23.0% by weight of the disinfectant composition; an anti-oxidant and stabilizer agent for stabilizing anti-infective and antiseptic agent in the liquid disinfectant composition being in the range of 4.0% to 8.

Abstract: The present invention relates to the disinfection of surfaces with a liquid disinfecting composition comprising a peroxy bleach, an antimicrobial active of essential oil, and a shear thinning polymeric thickener.

Abstract: A system for delivering an oral care substance to the oral surface, the delivery system comprising a strip of flexible material having a sufficient flexibility to form to the contours of the oral surface. The strip of material is readily conformable to oral surfaces without permanent deformation when the delivery system is placed there against. The oral care substance is applied to the strip of material such that when the delivery system is placed on the oral surface the active contacts the surface. The oral care substance also provides adhesive attachment between the strip of material and the oral surface so as to hold the delivery system in place for a sufficient amount of time to allow the active to act upon the oral surface.

Abstract: The invention relates to a tooth-whitening varnish composition, comprising 6-20% of carbamide peroxide, 2-9% of film forming agent and 77-88% of volatile organic solvent, based on the total weight of the composition. The volatile organic solvent is selected from ether, ethylacetate, ethyl alcohol, or acetone. The film forming agent is artificial or natural material selected from cellulose, polyvinyl, butyral, coumarone resin or shellac. The composition can rapidly form films on dry tooth surfaces, and a remarkable tooth-whitening effect can be obtained.

Abstract: A method to disinfect a porous solid medium, such as soil, includes the steps of embedding a plurality of electrodes into the porous solid medium and applying a plurality of alternating current voltage pulses between the electrodes. The voltage pulses have a peak voltage of at least 10 kilovolts and are of an intensity and duration effective to generate a quantity of ozone. The ozone is produced in quantities sufficient to disinfect the porous solid medium.

Abstract: The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.

Abstract: The method for the preparation of aqueous solutions containing performic acid formed by reaction of formic acid and hydrogen peroxide n the presence of a catalyst, the catalyst being a compound containing at least one ester group and/or group (a) differing from a carboxylic acid group and an alcoholic group, preferably a carboxylic acid ester, and aqueous solutions containing performic acid, formic acid, hydrogen peroxide, and a compound containing at least one ester group and/or group (a) differing from a carboxylic acid group, and the use of such solutions.

Abstract: The present invention comprises a concentrated solid or semi-solid disinfectant or sterilant composition for use in an aqueous disinfecting or sterilizing solution, comprising an oxidant and a protected glutaraldehyde such as a glutaraldehyde bisulfite addition compound (GBS): ##STR1## or a glutaraldehyde dioxime compound (GDO): ##STR2## The present invention further provides a method for disinfecting or sterilizing a surface or apparatus comprising the steps of mixing a concentrated solid or semi-solid glutaraldehyde sterilant composition comprising an oxidizing compound and a protected sterilant with water to form a solution and bringing the solution into contact with the surface or apparatus.

Abstract: The present invention relates to a method for preparing a preparation for bleaching teeth or for treating skin complaints and mucous membrane disorders, in which method at least the following are combined: (a) a gel or paste in which a component (i) is present, component (i) being composed of at least a cation A.sup.n+ and an anion O.sub.m X.sup.- ; where A is a metal from Group 1 or 2 of the periodic system, n=1 or 2, X is a halogen atom and m=1-4, and (b) a gel or paste in which a component (ii) is present, component (ii) being composed of at least a cation A.sup.n+ and an anion [B.sub.p O.sub.q ].sup.r-, where A is a metal from Group 1 or 2 of the periodic system, p=1-4, q=1-8 and r=1-3.

Abstract: Stable oxidizing biocide formulations containing bromine are provided for biofouling control in industrial water systems. The formulations contain at least one stable oxidizing bromine compound that is prepared from at least one oxidizing chemical reagent, at least one bromine source and at least one bromine or halogen stabilizer. The resulting products are a mixture of stable oxidizing bromine compounds that can be used as a primary or secondary biocide in an industrial water system.

Abstract: A medical gas mixture which comprises from 20 to 70% oxygen, from 1 to 10% carbon dioxide and the balance, except for incidental constituents not adversely affecting the basic properties of the gas mixture, being helium. The subject mixtures are useful in the treatment of asthma and in enhancing magnetic resonance imaging.

Abstract: A formed cream substitute for the addition to hot meals and a method for its preparation. The formed cream substitute for the addition to hot meals is formed by working 20 to 60% cream powder and 10 to 50% fat powder in a 15 to 50% matrix of pure fat. The cream substitute according to the invention can be provided in the form of lumps, in the form of cubes, or in the form of a granulate. The cream substitute can be stored well at room temperature and has, on a weight basis, a higher effectiveness than liquid cream.

Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.

Abstract: A new chewing gum with teeth whitener for helping whiten and brighten teeth while helping freshen the breath. The inventive device includes an elongate gum member having a central bore extending along its longitudinal axis. Extending through the central bore to substantially fill the central bore is a whitening gel which includes a whitening agent for whitening teeth while chewing the gum. The elongate gum member is divided along its length into a plurality of separable chewing portions such that each chewing portion includes portion of the gum member and a portion of the whitening gel member.

Abstract: A method for forming an iodine disinfecting solution that continuously generates free molecular iodine at a controlled average rate of at least 0.2 ppm per hour over a sustained and extended time period. The method involves combining persulfate anions and iodide anions in sufficient quantity in an aqueous medium having a resulting pH of less than about 6.5 so as to create an iodine generating capacity in said aqueous medium of between 1.5 and 6.5 with a generated concentration of at least 5 ppm of free molecular iodine and maintaining this concentration over the course of the extended time period.

Abstract: The present invention relates generally to the method for the production of liposomal microencapsulated boron-containing products to be used for agricultural formulations. More specifically, a new method of production of liposomal microencapsulated is disclosed for active agents such as pesticides. A lecithin is mixed with an organic solvent in a certain proportion so as to provide solutions with varied levels of solubilized lecithin. The particular solvent being used will depend on the amount of active agent (AA) desired in the final solution. The formulation of the lecithin/organic solvent mixture is then allowed to settle. After settling, the top layer is separated and saved, while the bottom layer is discarded. An AA is then added to form a concentrate that is added to water for vesicle formation. Boron-containing materials formulated according to the invention may now be applied to agricultural field crops and fruits.

Abstract: A flash-dry disinfectant composition for use as a hand wash is described. The composition consists of a C.sub.2 -C.sub.5 alcohol, a hydrogen peroxide solution and a bacteriostatic skin emollient. The C.sub.2 -C.sub.5 alcohol is preferably isopropanol. The composition contains at least about 15% to about 35% by weight of hydrogen peroxide solution in order to ensure a bacteriacidal effect with short term exposure to the composition. The composition has broad application in the food and health care industries. The advantage is a flash-dry disinfectant which may be used in place of lengthy scrub procedures effectively destroying bacteria without known risk of evolutionary resistance and which requires no towels or associated paraphernalia.

Abstract: Hereby established is a method of disinfection by ozone which is safe, clean, more reliable, and more efficient than prior methods. The method comprises a step of calculating the amount of ozone which would be required to solely disinfect bacteria if there were no co-existing materials, a step of calculating the amount of ozone which will be consumed by actual co-existing materials and a step of applying the total value of the two ozone amounts in proper forms, such as, gas or liquid, etc., preferably in the form of aqueous solution, to the object to be disinfected. This method can be consistently adopted for disinfection on very wide varieties of bacteria.

Abstract: A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment.

Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. In preferred embodiments, the aqueous solution has between about 0.01% and about 0.8% hydrogen or benzoyl peroxide and between about 0.01% and about 0.4% sodium bicarbonate. In more preferable embodiments of the present invention, the oral lavage (formulation) includes hydrogen peroxide at a concentration of about 0.4% and sodium bicarbonate at a concentration of about 0.2%.

Abstract: A method for whitening teeth is provided which involves applying to the teeth a mixture of a peroxide and a bicarbonate salt. Advantageously, the peroxide and bicarbonate salt are stored as active ingredients in separate respective compositions of a dispensing container. Preferably the dispensing container is a pump in the form of an upper and lower body telescopically engageable one with another, the upper body including at least two hollow and separate parallel cylinders each containing one of the compositions. These compositions may then be dispensed through relative compression of the pistons within the cylinders.

Abstract: A system for delivering a tooth whitening substance to a plurality of adjacent teeth, the delivery system comprising a strip of flexible material having a sufficient flexibility to form a curved shape on a plurality of adjacent teeth and a tooth whitening substance. The strip of material is readily conformable to the teeth surfaces and to interstitial tooth spaces without permanent deformation when the delivery system is placed thereagainst. The tooth whitening substance is applied to the strip of material such that when the delivery system is placed on the surface of the teeth, the substance contacts the surface providing an active onto the surface. The substance also provides adhesive attachment between the strip of material and the surface to hold the delivery system in place for a sufficient amount of time to allow the active to act upon the surface.

Abstract: The creamy bleaching agent suspension is mixed with an oxidizing agent prior to applying it to the hair to form a composition for bleaching or decolorizing hair. This creamy bleaching agent suspension contains less than 2.5% by weight water and a mixture of at least one inorganic persalt, at least one alkaline reacting salt, from 0.5 to 20 percent by weight of a thickening substance, which consists essentially of an acrylic acid polymer and one or more cellulose, alginate and/or polysaccharide polymers, and from 26.5 to 35 percent by weight of at least one oil or wax, and, as needed, one or more cosmetic additive ingredient. From 0.1 to 3 percent by weight of the acrylic acid polymer must be present in the composition.

Abstract: A delivery system for a tooth whitening substance includes a strip of material having a flexural stiffness less than about 50 grams/centimeter as measured on a Handle-O-Meter per ASTM test method D2923-95. The strip of material is readily conformable without permanent deformation to a shape of a tooth when the delivery system is placed thereagainst. The tooth whitening substance is applied to the strip of material such that when the delivery system is placed on a surface of the tooth, the substance contacts the surface providing an active onto the surface. The substance also provides adhesive attachment between the strip of material and the surface to hold the delivery system in place for a sufficient time to allow the active to act upon the surface. A method of delivery includes pre-coating the strip of material, having the wearer apply substance to the strip of material, or having the wearer apply the substance directly to the surface before applying a strip of material.

Abstract: A container, composition and method for preserving treatment solutions, in which the composition includes weak and strong preservatives. The dispensing container includes media within a dispensing tip which media removes or alters the strong preservative, while allowing the weak preservative to inhibit microbial growth in the tip media. The dispensing container is especially useful in delivering to the ocular environment ophthalmic solutions which are essentially free of strong preservative which may cause patient discomfort. A dispensing container including a pH-preserved pilocarpine solution is disclosed in one embodiment.

Abstract: The invention concerns a hygienic agent for use in hemodialysis. This hygienic agent based on peracetic acid has an aqueous solution containing 6 to 8 weight % hydrogen peroxide, 0.1 to 1 weight % peracetic acid and 2 to 10 weight % acetic acid. Application to the disinfection, sterilization of dialysis generators, dialyzers, hemofilters and hemodialyzers and circuits of water treatment for hemodialysis.

Abstract: Provided is an anti-microbial composition containing an ester of formic acid, an oxidizer, performic acid and water. Also provided is a premix for making the anti-microbial composition having two parts. One part contains the ester of formic acid and a second part contains the oxidizer. Another method is provided for making the anti-microbial composition in which the ester of formic acid is combined with the oxidizer and water. A further method is provided for sterilizing medical devices, including dialyzer filter modules, wherein the anti-microbial composition is capable of a 1:1 to a 1:12 dilution with water.

Abstract: Apparatus and methods for treating feet infected with fungi are disclosed. In one embodiment, such an apparatus includes a container adapted to hold a quantity of liquid aqueous medium and sized so that only a portion of an adult human body can be placed therein; an ozone generator sized and adapted to produce sufficient ozone to effectively ozonate the liquid aqueous medium in the container; and a transfer assembly cooperating with the container and said ozone generator to pass ozone produced by the ozone generator to the liquid aqueous medium in the container.

Abstract: A method of increasing the nitric oxide concentration in the blood of a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation; and (b) administering the treated blood to a human. The method of the invention is useful for treating a variety of conditions benefitted by increased blood levels of nitric oxide.

Abstract: A low odor, aqueous, quick acting room temperature disinfectant solution primarily useful for medical instruments to disinfect within a half hour or less. The composition comprises a reacting or synergistic combination of hydrogen peroxide and from about 1% to 30% by weight of a water soluble organic acid or salt form thereof with the acid preferably being selected from the group consisting of malonic and succinic acids.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: A tooth-paste composition for whitening teeth and method for manufacture, the composition comprising a water-free, non-hygroscopic base and carbamide peroxide.

Abstract: A dual component whitening dentifrice composition is disclosed which comprises a first dentifrice component containing a peroxide compound such as urea peroxide and a second dentifrice component containing an abrasive such as alumina or silica which is incompatible with the peroxide, the first and second dentifrice components being maintained separate from the other until dispensed and combined for application to teeth requiring whitening.

Abstract: Method of preserving mineral slurries from microbiological attack comprising introducing a nitrite or TBIP followed by sufficient 3-isothiazolone biocide to protect the slurry from attack. Mineral slurries which are so protected are also disclosed.

Abstract: A method for hair treatment is disclosed wherein a first treatment solution comprising tea tree oil is periodically applied to the scalp for at least 10 days. Then, a second treatment solution comprising chlorine dioxide is periodically applied to the scalp, immediately followed by application of an acidic solution having an acidity effective to release the oxygen in the chlorine dioxide solution, for at least 1 month. Finally, a third treatment solution comprising saw palmetto berry extract is periodically applied to the scalp for at least 1 month. Also disclosed is a hair treatment kit comprising a first treatment solution comprising tea tree oil, a second treatment solution comprising chlorine dioxide, an acidic solution having a pH effective to release the oxygen from said chlorine dioxide in said second treatment solution, and a third treatment solution comprising saw palmetto berry extract.

Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.

Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a .[.define.]. .Iadd.defined .Iaddend.proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.