Abstract: Disclosed are in-the-eye uses of chlorine dioxide-containing compositions as effective ophthalmic antiseptics and as effective ophthalmic surgical irrigants. Surprisingly low concentrations of chlorine dioxide are effective in such applications. In addition, the presently useful compositions are ophthalmically acceptable.

Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections contains an electrolyzed saline containing regulated amounts of ozone and active chlorine species wherein the ozone content is between about 5 and 100 mg/L and the active chlorine species content of between about 5 and 300 ppm. The active chlorine species contains free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the desired active ingredients. The solution is preferably utilized at an isotonic saline concentration and may be adjusted with hypertonic saline. The solution may be used for the in vitro treatment of infected whole blood, blood cells or plasma to reduce contamination and is effective in treatment of fluids infected with HIV, hepatitis and other viral, bacterial and fungal agents.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: A method for treating an individual to prevent the occurrence of pressure ulcers and facilitate the healing of previously existing pressure ulcers. In accordance with the present invention, a responsible individual must first determine which linens will contact pressure points on the individual as the individual lies upon a support surface. Once the appropriate linens are determined, they are prepared by cleaning the linens in ozonated wash water to limit chemical residuals and maintain neutral pH levels on the linens, wherein the linens exhibiting no chemical residuals and neutral pH cause no chemical reaction with the skin of the individual. Finally, the linens are placed into use so that they contact the skin of the individual at pressure points.

Abstract: An aqueous composition comprising a lower aliphatic peracid, a corrosion inhibitor and a peroxide stabilizer and/or peracid stabilizer, is useful for disinfecting medical equipment, particularly metal components of such equipment. A process for obtaining such compositions is also provided and comprises mixing a first aqueous solution comprising a lower aliphatic peracid with a second aqueous solution comprising hydrogen peroxide, a corrosion inhibitor and a hydrogen peroxide stabilizer and/or a peracid stabilizer. The first and second aqueous solutions can form a two pack system for obtaining such compositions.

Abstract: A tooth surface treating agent is provided which comprises a polymerization catalyst and an acidic compound, both water-soluble, the treating agent being capable of enhancing tooth adhesion. The tooth surface treating agent imparts strong adhesion to the enamel and dentin of teeth through simultaneous treatment thereof. The invention is mainly intended for use in the field of dentistry, but is also applicable as a treating agent for vital hard tissues in such fields as surgery, and orthopaedic or plastic surgery.

Abstract: An extrudable composite multilayer dentifrice composition for cleaning teeth containing reactive bicarbonate and peroxide ingredients which do not interact during storage or when extruded together from a container onto a toothbrush but react in the oral cavity when mixed during tooth brushing, the composition comprising two separate dentifrice components, one component containing a peroxide ingredient and the other component containing a colorant reactive with the peroxide ingredient, the components having substantially equivalent viscosity which are maintained in stable discrete layered phases in interfacial contact with each other prior to extrusion without interaction of the peroxide and the colorant and which are extrudable together in interfacial contact without interaction of the ingredients.

Abstract: An oral composition is provided that includes a peroxide, a triphenylmethane class dye, a tartrazine class dye and a pharmaceutically acceptable carrier. Preferred embodiments of the dye system are FD&C Blue 1 and FD&C Yellow 5, in combination providing a green color. This green color is stable against degradation from the peroxide.

Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections containing an electrolyzed saline solution having a content of regulated amounts of ozone and active chlorine species. The ozone content is 5 to 100 mg/L (milligram per liter) and the chlorine species content is 5 to 300 parts per million (ppm). The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the active ingredients. The solution is used at an isotonic saline concentration and my be adjusted with hypertonic saline. The solution is used in vitro treatments of infected whole blood, blood cells or plasma to reduce contamination. The solution may also be administered to warm blooded animals, including humans by intravenous injection.

Abstract: A stable, shippable microbicidal composition including between about 0.2 to 8% hydrogen peroxide, about 0.2 to 11% peracetic plus acetic acid, 0 to about 1.0% sequestrant such as organic phosphonic acid or its salt and water, and surfactant between 0 and about 1% with the ratio of total acid to H.sub.2 O.sub.2 being between about 1.0 and 11.

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections includes an electrolyzed saline containing regulated amounts of ozone and active chlorine species wherein the ozone content is between about 5 and 100 mg/L and the active chlorine species content of between about 5 and 300 ppm. The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the desired active ingredients. The solution is preferably utilized at an isotonic saline concentration and may be adjusted with hypertonic saline. The solution may be used for the in vitro treatment of infected whole blood, blood cells or plasma to reduce contamination and is effective in treatment of fluids infected with HIV, hepatitis and other viral, bacterial and fungal agents.

Abstract: Provided is an anti-microbial composition containing an ester of formic acid, an oxidizer, performic acid and water. Also provided is a premix for making the anti-microbial composition having two parts. One part contains the ester of formic acid and a second part contains the oxidizer. Another method is provided for making the anti-microbial composition in which the ester of formic acid is combined with the oxidizer and water.

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: The present invention relates to the discovery that the inclusion of effective amounts of an irritation reducing compound selected from the group consisting of allantoin, glycerine, aloe vera and mixtures, thereof, in a chlorine dioxide generating composition will substantially reduce skin irritation which is caused by chlorine dioxide exposure to the skin.

Abstract: A dentifrice composition containing reactive ingredients such as peroxide and bicarbonate compounds which are stabilized to decomposition during storage by incorporating in the dentifrice composition about 1.0 to about 5.0% by weight of polyethylene glycol 2000.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: Aqueous solutions containing peroxodisulfate ions are described for the preparation of medicaments for the treatment of malignant cells of human and animal bodies. Furthermore, a process for the preparation of the agent and a device for carrying out the process are described. The agents are available, for instance, by actinic irradiation of aqueous solutions containing anions of oxygen acids of sulfur, particularly sulfate ions and/or peroxodisulfate ions, and having a pH-value of from 2 to 7.

Abstract: A storage stable oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of polyvalent metal compounds and fluoride compounds do not affect the stability of the composition as well as reactive ingredients such as peroxide and bicarbonate compounds.

Abstract: A method of inhibiting the aggregation of blood platelets in a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a blood platelet aggregation-inhibiting effective amount of ozone gas and ultraviolet radiation; and (b) administering the blood treated in step (a) to a human. A method of stimulating the immune system, and of treating immune system disorders, by treating blood with ultraviolet radiation and ozone gas, followed by administering the treated blood to a human.Also disclosed is a method of treating Raynaud's Disease by contacting about 0.01 ml to about 400 ml of human blood with a blood platelet aggregation-inhibiting effective amount of ozone gas in admixture with oxygen gas, and ultraviolet radiation, while maintained at a temperature in the range of from about 37.degree. C. to about 43.degree. C. for a period for about 0.5 minutes to about 10 minutes, and administering the blood so treated to a human patient with Raynaud's Disease.

Abstract: Provided is an anti-microbial composition containing an ester of formic acid, an oxidizer, performic acid and water. Also provided is a premix for making the anti-microbial composition having two parts. One part contains the ester of formic acid and a second part contains the oxidizer. Another method is provided for making the anti-microbial composition in which the ester of formic acid is combined with the oxidizer and water. Also provided is a method for sterilizing devices by contacting the surface of the device with the anti-microbial composition containing the ester of formic acid, an oxidizer, performic acid and water.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: A cleaning and sanitizing method for soiled solid surfaces, especially clean-in-place process facilities, is described which involves contacting the surfaces first with an aqueous ozone cleaning composition having a pH greater than 7, wherein the ozone is generated by electrical discharge, then quenching the excess ozone and simultaneously sanitizing the surfaces by contact with an aqueous composition containing hydrogen peroxide, a C.sub.1 -C.sub.10 peroxyaliphatic carboxylic acid or a mixture thereof.

Abstract: Method of controlling fresh water mussels of the Dreissenidae family (zebra and quagga mussels) by direct contact with peracetic acid or indirectly by application to an environment where control is desired. The biofouling of environments, such as fresh water intakes, conduits and storage systems of power and water treatment systems, and of processing streams of industrial plants, is thereby reduced or eliminated.

Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.

Abstract: Prophylactic and therapeutic applications of peroxidases for the manufacture of medicaments for the treatment and prevention and treatment of enveloped virus infections and, in particular, of herpes simplex and immunodeficiency virus infections. The medicaments include a peroxidase, a substrate and a peroxide in a pharmaceutically acceptable carrier. Peroxidases of the medicaments include lactoperoxidase and myeloperoxidase. The medicaments are formulated with a pharmaceutically acceptable carrier for topical, oral and injectable administration to individuals in need thereof.

Abstract: An antifungal agent for the treatment of skin disease such as athlete's foot, ringworm and tinea caused by dermatophytes, eczema, tinea or various fungi, which comprises a 100 weight % of detergent solution including 0.01-40 weight % of sodium hypochlorite, 0.01-30 weight % of sodium sulfite, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of sodium chlorate, 0.01-40 weight % of potassium chlorate, 0.001-35 weight % of hydrogen peroxide, 0.01-40 weight % of ozone water, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of potassium nitrite, 0.001-1 weight % of nonionic surface active agent and 1-90 weight % of water.It is characterized in that trichophyton, eczema or various fungi in the dermis or deep layer are allured by oxygen contained in the antifungal agent to or near the surface of the skin for easy sterilization by oxidation, reduction, bleaching and fungicidal activity.A liquid agent is also efficacious for the treatment of a burn of the skin and of stiffness in the shoulders.

Abstract: The growth of algae, fungi and pathogenic organisms in commercial and recreational waters, such as cooling towers, swimming pools and spas, may be controlled by adding to the water a primary sanitizing agent, preferably poly(hexamethylene biguanide) ("PHMB"), and a potentiating adjuvant comprising a calcium ion-chelating agent, preferably ethylenediamine tetraacetic acid ("EDTA"), in amounts such that the adjuvant renders the composition algicidal and fungicidal in water. The water may be further treated with a peroxy salt as a backup agent, preferably sodium perborate, or the calcium ion-chelating agent and peroxy salt may be combined as a shock treatment to water being treated with the primary sanitizing agent.

Abstract: An antifungal agent for the treatment of skin disease such as athlete's foot, ringworm and tinea caused by dermatophytes, eczema, tinea or various fungi, which comprises a 100 weight % of detergent solution including 0.01-40 weight % of sodium hypochlorite, 0.01-30 weight % of sodium sulfite, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of sodium chlorate, 0.01-40 weight % of potassium chlorate, 0.001-35 weight % of hydrogen peroxide, 0.01-40 weight % of ozone water, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of potassium nitrite, 0.001-1 weight % of nonionic surface active agent and 1-90 weight % of water.It is characterized in that trichophyton, eczema or various fungi in the dermis or deep layer are allured by oxygen contained in the antifungal agent to or near the surface of the skin for easy sterilization by oxidation, reduction, bleaching and fungicidal activity.A ligand agent is also efficacious for the treatment of a burn of the skin and of stiffness in the shoulder.

Abstract: An apparatus and method for producing an antibiotic liquid. The apparatus includes an ion generator that produces negatively-charged molecules of the formula [MO.sub.x ].sup.-, where M is a positive ion, O is oxygen and x is a number at least equal to 3, and means for mixing a gas containing said molecules with a liquid such as water. Molecules [MO.sub.x ].sup.- are produced in a generator that comprises a specially shaped anode and cathode spaced apart from each other in a non-conducting housing. When a substantially constant voltage is applied across the anode and cathode, a plasma forms between and around them that in turn forms a magnetic field around the plasma and the anode. Diatomic oxygen molecules enter the housing and are polarized by the magnetic field and the resulting oxygen ions accelerated toward the plasma.

Abstract: An improved tooth and gum paste formed as a stable, single component composition that includes a non-aqueous carrier containing urea, hydrated silica, fluoride, sodium bicarbonate, pyrophosphate, and a peroxide, one or more of the ingredients being microencapsulated and which in use functions as an aid in preventing periodontal disease by reducing incidents of plaque as well as controlling tartar formation, and also as an aid in preventing dental caries and oral odors; and the method of compounding such improved tooth and gum paste.

Abstract: An apparatus and method useful for disinfecting a contact lens are disclosed. The apparatus includes a color indicator component comprising a transition metal component and a polymeric matrix material. This transition metal component, which is immobilized on the polymeric matrix material, provides a color indication of the presence of the oxidative contact lens disinfectant, e.g., hydrogen peroxide, in a liquid medium.

Abstract: Method of controlling the zebra mussel by direct contact with peracetic acid or indirectly by application to an environment where control is desired. The biofouling of environments, such as fresh water intakes, conduits and storage systems of power and water treatment systems, and of processing streams of industrial plants, is thereby reduced or eliminated.

Abstract: An oral composition and method is provided that includes a peroxygen compound such as hydrogen peroxide, a fluoride-containing anticaries agent and a zinc compound such as zinc citrate. The presence of the zinc compound inhibits decomposition that ordinarily would be induced by the presence of fluoride.

Abstract: Compositions and methods useful in destroying residual oxidative disinfectant, e.g., used to disinfect a contact lens, are disclosed. In one embodiment, the method comprises contacting an oxidative disinfectant-containing liquid medium with a material selected from glutathione, oxidized glutathione and mixtures thereof, and a co-factor selected from nicotinamide adenine dinucleotide phosphate, nicotinamide adenine dinucleotide and mixtures thereof in the presence of glutathione reductase in an amount effective to promote the oxidation of the co-factor.

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract: Peracetic acid compositions containing at least one thickening agent and optionally a stabilizer chosen from sequestering agents, free-radical scavengers and mixtures containing two or more of these products.The preferred compositions are obtained by successively incorporating at least one stabilizer and then at least one thickening agent.These compositions are especially capable of being employed for the disinfection of large bulks which are difficult to immerse and of nonhorizontal surfaces, and for detergency or bleaching at low temperature.

Abstract: An oral hygiene composition in a suitably applicable form for whitening and cleaning teeth provides a non aqueous composition containing an oxygen releaser such as calcium peroxide, magnesium peroxide or potassium chlorate. The oxygen in these agents is stable in the composition until the composition meets water during actual brushing at which time the oxygen is released to effect a bleaching action removing stains from the surface of the teeth, thereby serving to whiten them. The composition may be formed with other known dental hygiene constituents providing for whitening and hygiene in one application.

Abstract: A method for destroying cyst of noxious plankton, which comprises mixing in ballast water hydrogen peroxide or a compound producing the same and maintaining an effective concentration thereof for destroying cyst of noxious plankton.

Abstract: The present invention is directed to a method for sanitizing a system where microorganisms are capable of growing which comprises adding to said system a microbiocidally effective amount of an oxidant capable of releasing nascent or singlet oxygen for inhibiting the growth of microorganisms, and a microbiocidally effective amount of a microbicide for inhibiting the growth of microorganisms.

Abstract: Abrasive dentifrice compositions containing an oxygen liberating whitening compound which is stable with respect to oxygen level and exhibits heightened and rapid whitening of teeth and stain removal which comprises a combination of a dicalcium phosphate compound and a metal ion free peroxide compound.

Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a define proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.

Abstract: An oral composition is provided that includes a peroxygen compound such as hydrogen peroxide, a fluoride-containing anticaries agent and a tin compound, especially stannous chloride. The tin compound stabilizes the peroxygen compound against decomposition that ordinarily would be induced by the presence of fluoride.

Abstract: A disinfectant effective against substantially all bacteria, fungi, bacterial and fungal spores, and viruses. The disinfectant composition consists of: from 60 to 90% by weight of potassium monoperoxysulfate; from 2 to 10% by weight of malic acid; from 2 to 6 % by weight of sulfamic acid; from 0.25 to 3% by weight of EDTA Na.sub.2 ; from 1 to 15% by weight of alkylated ether of polyethylene glycol; wherein a total of 100% by weight of the composition is obtained.

Abstract: An aqueous abrasive oral composition which exhibits heightened and rapid whitening of teeth is obtained when using a combination of a dicalcium phosphate compound, a metal ion free peroxide, a chelating agent and a thickening agent.

Abstract: A method for the simultaneous cleaning and disinfecting of contact lenses based upon the combined use of a proteolytic enzyme for cleaning and a peroxidative enzymatic reaction with donor and acceptor molecules and a thiol agent for color control.

Abstract: A method of preparing an implant body in order to optimize the healing time of said implant, comprising bringing the implant body for a limited period of time into contact with a hydrogen peroxide solution at least on the surfaces intended to come into contact with surrounding tissue when implanted, the treated surfaces being cleaned by rinsing. The treatment of the implant surface with hydrogen peroxide can be supplemented with incorporation of biomolecules, such as peptides, proteins and steroids, and also other substances such as inorganic ions and crystals. The compounds to be coupled to the implant surface may promote the healing and/or binding of the surrounding tissue.

Abstract: The invention discloses a method for inactivating infectious agents in a patient's blood in vivo. The method involves adminstering to the patient a non-toxic, infectious agent inactivating amount of a mixture of oxygen and ozone. The mixture is preferably administered via rectal insufflation or via authohemotherapy.

Abstract: Apparatus for applying a disinfectant solution which may include hydrogen peroxide, a salt and a buffer to an instrument wherein the instrument can be inserted into an opening in the wall of a vessel containing a disinfectant normally at a level below the opening. A floatation plunger is urged downwardly to displace the disinfectant to a level in engagement with the instrument and the electrodes are energized to activate the disinfectant. A magnetic latch holds the floatation plunger in place during disinfection and the disinfectant level is sensed to enable energization of the electrodes only when the level is sufficient to engage the instrument.