Abstract: The present invention relates to wood preservative compositions comprising an effective amount of a pyrethroid compound in combination with an isothiazolone compound, methods and processes for preserving wood using the wood preservative compositions of the invention, and wood comprising the wood preservative compositions of the invention.

Abstract: The invention relates to the treatment of burn injuries. Described are methods for modulating a burn injury in a subject, the method comprising providing the subject with a gene-regulatory peptide or functional analogue thereof. Also described is the use of an NF-kappaB down-regulating peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of burn injury of a subject.

Abstract: A stethoscope head cover configured to envelop a head of a stethoscope includes a cover member with a cavity therein. The cover member includes first and second openings. The first opening has a size sufficient to slidably engage a cord associated with the head of the stethoscope, and the second opening has a size sufficient to allow the head of the stethoscope to be extended therethrough. A stethoscope head cover with a cavity therein and a first opening having a size sufficient to allow the head of the stethoscope to be extended therethrough. The head cover can further include a biocidal environment within the cavity of the cover member. A method of sanitizing a stethoscope head includes providing a stethoscope head cover having a biocidal environment within a cavity of the stethoscope, and engaging a stethoscope head with the stethoscope head cover.

Abstract: The present invention is directed to a method for treating the foot of an animal, including treatment of infectious diseases of the foot of an animal. Among the various aspects of the invention is provided a method of contacting a foot of an animal with an antimicrobial composition comprising water, sulfuric acid, ammonium sulfate or sodium sulfate, and, optionally, an antimicrobial metal. Also provided is a method of rotational treatment wherein a foot of an animal is contacted with a series of antimicrobial composition with and without an antimicrobial metal component.

Abstract: Provided herein are methods and system to increase selective thermomechanical damage to a biological body, such as a cancer cell or cell associated with a pathophysiological condition. The biological body or cancer cell is specifically targeted with nanoparticulates comprising one or more targeting moieties which form nanoparticulate clusters thereon or therewithin. Pulsed electromagnetic radiation, e.g., optical radiation, having a wavelength spectrum selected for a peak wavelength near to or matching a peak absorption wavelength of the nanoparticulates selectively heats the nanoparticulates thereby generating vapor microbubbles around the clusters causing damage to the targets without affecting any surrounding medium or normal cells or tissues. Also provided is a method of treating leukemia using the methods and system described herein.

Abstract: A method for making an elastomeric material containing an antimicrobial composition such as a dispersion of silver oxide that is suitable for implantation within the body. The elastomer made in accordance with this method extends the amount of work-time available for processing the elastomer into an article as compared with the work-time available when using prior art compounding methods.

Abstract: Compositions for the treatment of periodontitis and methods of use thereof are described. The compositions contain a polymer-iodine complex. The polymer-iodine complex can be suspended in a pharmaceutically acceptable carrier in which the complex is stable and the iodine is stable in its elemental form and/or a combined form (e.g., iodine-iodide complex). In one embodiment, the complex is prepared by the reacting a synthetic or semi-synthetic ionic polymer, with iodine and/or an iodide. The complex will preferably deliver iodine over an extended period of time for example over several days (e.g., at least 3 days, preferably at least 4 days, more preferably at least 5 days, most preferably at least 6 days), preferably at least a week, more preferably at least two weeks. In one embodiment, the polymer-iodine complex forms a gel, alone or by the addition of one or more gelling agents, upon administration into a periodontal pocket.

Abstract: A material composition, including metallic nanoparticles of silver, silver alloys, or copper, having antimicrobial properties is disclosed. The metallic nanoparticles are embedded or encapsulated in a matrix formed of chitosan or chitosan derivative-based compounds.

Abstract: A composition and method for treatment of viral-induced skin lesions, such as warts, are described. The composition is comprised of tea tree oil and/or derivatives from tea tree oil and one or more minerals, such as iodide and/or selenium. The composition is used to prepare medicaments for the treatment of viral-induced lesions, such as warts caused by the Molluscum contagiosum virus, human papillomavirus, and/or herpes simplex virus. The composition is applied topically to the human epidermis and/or to the genital tract as needed.

Abstract: Textiles and also dishes and other household implements which are cleaned in laundry machines or dish washing machines can be afforded protection from an increasing colonization by bacteria when the textiles or the dishes are washed together with a microbicidal repository including a solid fiber composite of ion-exchanger particles loaded with silver ions, and a cellulose matrix.

Abstract: A composite for inhibiting algae growth comprising a polypore base carrier and a nano-metal mixture coated on the carrier, wherein the mixture comprising a nano-metal particle and a substance for fixing the particle on the carrier.

Abstract: An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The silicone resin may be a dispersion of about 40 to about 60 w/v % of an RTV silicone resin in a solvent, a liquid silicone resin, or a solid silicone resin. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article and permitting the solvent to evaporate. It may also be formed by making a mixture of about 5 to about 12 wt % of an antimicrobial formulation and about 88 to about 95 wt % of a liquid or solid silicone resin and molding, overmolding, or extruding the article from the compounded mixture.

Abstract: The present invention relates to micro-sized particles having anti-biocontaminant properties. Each particle is comprised of a central metal core, or support structure, (for example, alumina oxide) and has on its surface, one or more anti-biocontaminant metals and at least one redox agent.

Abstract: A system and method for using nanoparticles for antimicrobial activity. The coding may include a polymeric film and a plurality of discreet first particles. The discreet particles may include silver metal, silver oxide or a combination of both. The discreet particles may be in contact with the polymeric film.

Abstract: The present invention is directed to a method of treating biofilms by exposure to heavy metals selected from the group comprising metal cations such as manganese, cobalt, nickel, copper, zinc, aluminum, silver, mercury, lead, cadmium and tin; metal oxyanions such as molybdate, tungstate and chromate; and metalloid oxyanions, alone or in combination with antimicrobials. The present invention also includes compositions and methods for preparing or treating medical devices and medications.

Abstract: A composition and method for vitalizing and stabilizing a cosmetic product, comprising: an inner cosmetic layer; and an outer shell including: metal ions; and an anhydrous cosmetic product. The metal ions are selected from the group consisting of: copper ions, silver ions, and gold ions. The concentration of the metal ions ranges from 2 ppm to 200 ppm. The two types of metal ions may be equal in concentration. Additionally, a composition for vitalizing and stabilizing cosmetics, includes: hydrophilic ions selected from the group consisting of copper ions, silver ions, and gold ions; and an anhydrous cosmetic product. The method includes: introducing hydrophilic ions into water substantially free of ions to form a solution; atomizing the solution; and combining the atomized solution with a cosmetic product. The method further includes inserting a pure sample of a desired element into the water substantially free of ions and running a current therethrough.

Abstract: This invention relates to antimicrobial polymeric articles containing metal salt particles having a particle size of less than about 200 nm dispersed throughout the polymer and methods for their production.

Abstract: The invention concerns novel hydrogels, a process for the preparation of these hydrogels and would contact materials comprising these hydrogels. These polyurethane hydrogels are obtained by the reaction of aliphatic isocyanate prepolymers with polyols comprising tertiary nitrogen in water.

Abstract: Gold suspensions with high concentrations of gold, and silver suspensions with high concentrations of silver, are provided. Gold or silver nanoparticles are put into suspension, where the metal nanoparticles are paired with silica. Biocompatible suspensions are one application. Noble metal particles, attached to the surface of silica particles, form a stable, non-agglomerated suspension due to the steric and repulsive properties of the silica particles. The noble metal particles are prepared by activating the surface of the silica particles and erecting nucleation sites for metal particle growth, and then growing the metal particles at the nucleation sites through a reduction procedure.

Abstract: The invention relates to a microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the microcapsule by treatment of the antimicrobial agent with a solution of the hydrophilic polymer is provided. Another embodiment of the invention is a method of preparing the microcapsule by coating of the antimicrobial agent with a polymer precursor followed by treatment with a reactive ingredient. Another embodiment of the invention is a method of preparing the microcapsule by melt compounding the antimicrobial agent with the hydrophilic polymer followed by grinding to the desired particle size. Polymer compositions comprising the microcapsules and a matrix polymer are also provided.

Abstract: This invention discloses novel antimicrobial materials comprising of nanocrystalline metal, metal oxide, and active oxygen species in a permeable structure. It also discloses the compositions of the inventive material enriched with different active oxygen species. The inventive material showed a strong antimicrobial ability over a wide spectrum of microbies. The average log-reduction value was eight within five minutes. The inventive materials can remain sterile in air over more than two months. The methods used to prepare this inventive material are disclosed.

Abstract: According to the present invention there are provided antimicrobial catheters and other medical devices having controlled release of an antimicrobial metal or metal ion. Specifically, antimicrobial catheters and other medical devices manifest antimicrobial properties as a result of the incorporation therein of antimicrobial microcapsules comprising an inorganic antimicrobial agent and a hydrophilic polymer.

Abstract: In a process for the preparation of an article having a contact biocidal property, there is provided a polymer solution which contains atomic/metallic silver in suspension or complexed with the polymer and/or which contains a silver compound in solution, in suspension or complexed with the polymer. This polymer solution is applied to a substrate by impregnation or surface deposition, thus coating the substrate. Alternatively, it is possible to convert the polymer solution to a fibre, film, powder or foam, effectively forming the article from the polymer solution instead of coating an existing article. In either case, any silver compound present is reduced to atomic/metallic silver, and the resultant article is dried. Chitosan is preferably used as the polymer, although poly(vinyl alcohol) and sodium alginate can also be used. The polymer may be cross-linked at a suitable point in the process to insolubilize it.

Abstract: The invention relates to a water-insoluble silicate glass powder, wherein the silicate glass powder exhibits glass particles with the following composition in percentage by weight on an oxide basis: SiO2 20-80 Na2O ?5-30 K2O 0-5 P2O5 ?0-15 B2O3 ?0-10 CaO ?4-30 MgO 0-8 Al2O3 0-7 Fe2O3 0-2 as well as conventional fining agents in conventional quantities. The invention is characterized in that the glass particles contain at least one of the following components ZnO AgO CuO CeO2 GeO2 TeO2 wherein these components are concentrated in the regions of the glass particles that are near the surface.

Abstract: The present invention provides antimicrobial coatings for coating substrate surfaces, particularly medical devices, for preventing bacterial adhesion and biofilm formation by inhibiting microbial growth and proliferation on the coating surface. The antimicrobial coatings are composed of a hydrogel and a bioactive agent including a substantially water-insoluble antimicrobial metallic material that is solubilized within the coating. Antimicrobial coating formulations for obtaining such coatings, and coating methods are also described.

Abstract: An antimicrobial composition comprising metal particles that may be silver, copper, or gold together with a surfactant such as benzalkonium chloride in a liquid medium, which is preferably deionized water, that will not react with the other constituents of the antimicrobial composition. Preferably, the composition also comprises a source of iodine, such as poly(vinyl pyrrolidone)-iodine complex. And a substrate carrier having the same type of metal as the particles deposited onto it may also be introduced into the liquid medium. The metal particles are preferably nanoparticles but may be in the micron size, in the submicron size, or bulk particles.

Abstract: An improved method for fixedly binding particles of a solid, heat absorbing material or additive, especially polymer additives, to the surface of prepolymer and/or polymer particles.

Abstract: A method of building an orthopedic implant including the steps of mixing a powder having antimicrobial properties with a biocompatible powder to form a mixture. Next, the mixture is deposited on top of a substrate. The substrate may be part of the finished product or only a work platform. The mixture layer is then selectively melted.

Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.

Abstract: Chemical compositions in cream form for the treatment of Bovine Mastitis in cows, which compositions are combinations of Aloe Vera, Colloidal Silver, Castor Oil, Glycosperse, Peppermint Oil, Peppermint Leaf, Tea Tree Oil, Oregano Oil, Poke Root, Vitamin C, Menthol crystals, Salt, Polysorbate 80 and Guar/Xanthan Gum, which provides a cream that is applied externally in one or more applications, to the affected portion of the cows udder, for the time required to provide a cure for the Mastitis.

Abstract: A colloidal suspension comprising elemental silver and/or one or more alloys of silver is mixed with either an over-the-counter rhinitis medicine or a prescription rhinitis medicine. The resulting mixture is administered to rhinitis patients in the form of a spray.

Abstract: The invention relates to a biodegradable barrier network comprising at least two polypeptides, one being anionic and the other one cationic. The invention also relates to applicators and kits comprising components to be used to create said biodegradable barrier network. The invention also relates to the use of said applicator or kit in therapy, such as in medicine, veterinary medicine and horticulture.

Abstract: A deodorant composition comprising (i) a metallic deodorizing agent selected from copper, zinc, silver, platinum, nickel, iron, cobalt, a copper compound, a zinc compound, a silver compound, a platinum compound, a nickel compound, an iron compound, a cobalt compound and a mixture thereof, (ii) an carboxylic group-containing gelling polymer; and a liquid media. The deodorant composition has a three-dimensional shape selected from a block shape, a sphere shape, an ellipsoid shape, a cone shape and a cylinder shape and has a surface area of from about 24 mm2 to about 24 mm2.

Abstract: An antibiotic and deodorant material and a preparation method thereof are provided. At first, a mesoporous molecular sieve, a grafting agent and a solvent are reacted under a thermal flux system. The grafting agent has a structure of chemical formula I or II, wherein R1 and R2 are alkyl groups having 1 to 20 carbon atoms. The grafting agent can modify surfaces of the mesoporous molecular sieve. Then, the surfaces of the mesoporous molecular sieve are modified by silver ions. Finally, the mesoporous molecular sieve is reduced by a reducing agent to form an antibiotic and deodorant material.

Abstract: A liquid antiseptic and cleanser having improved long-term stability includes at least the following principal ingredients: deionized water; silver ion, polypectate, and ethylenediaminetetraaceticacid (EDTA). Presently preferred embodiments of the technology also include glycerine; 1,2-propanediol (a.k.a. propylene glycol); at least one surfactant from any of the families of alkylsulfates, sulfonates, alkanolamides, betaines, amine oxides, sarcosinates and sulfosuccinates; and a buffering compound sufficient to achieve a pH value within a range of 7.2 to 7.8.

Abstract: The present invention relates to a novel nasal formulation for nasal hygiene and to improve nasal airflow of people suffering from nasal congestion.

Abstract: A method is provided for depositing a hard wear resistant surface onto a porous or non-porous base material of a medical implant. The wear resistant surface of the medical implant device may be formed by a Laser Based Metal Deposition (LBMD) method such as Laser Engineered Net Shaping (LENS). The wear resistant surface may include a blend of multiple different biocompatible materials. Further, functionally graded layers of biocompatible materials may be used to form the wear resistant surface. Usage of a porous material for the base may promote bone ingrowth to allow the implant to fuse strongly with the bone of a host patient. The hard wear resistant surface provides device longevity, particularly when applied to bearing surfaces such as artificial joint bearing surfaces or a dental implant bearing surfaces. An antimicrobial material such as silver may be deposited in combination with a metal to form an antimicrobial surface deposit.

Abstract: The present invention provides disinfecting compositions having tuberculocidal and fungicidal efficacies for disinfecting and sanitizing inanimate surfaces. The disinfecting compositions contain thyme oil or thyme oil and origanum oil, a salt of a transition metal, a biobased surfactant and water. This improved disinfecting composition of the present invention is botanical, environmentally sustainable, non-toxic, mildly scented and highly stable.

Abstract: There is provided a process for reducing formaldehyde content of a gas comprising the step of contacting the gas with an aqueous oxidizing solution comprising at least one cation, a base, and H2O2 so as to oxidize at least a part of the formaldehyde contained in the gas into formic acid. Thus, a gas having a reduced content in formaldehyde as compared to the gas before the process and a solution comprising formic acid, are so-obtained. Such a process can be particularly useful for treating various types of gases containing formaldehyde.

Abstract: Methods for the production of deposition products including an oxidized metal species under both acidic and alkaline conditions, methods for the production of composite materials including a substrate and the deposition product, and products in the nature of deposition products and composite materials. The methods are particularly suited for depositing a very thin layer of a deposition product on a substrate and may be used to produce composite materials for use in many applications, including but not limited to electronics, materials engineering and medical applications. In a preferred embodiment, the metal is silver, the substrates are medical devices or components of medical devices and the deposition product includes an antimicrobially active oxidized silver species.

Abstract: Structures treated with a microbiological interception enhancing agent comprising of a water-soluble cationic material having a counter ion associated therewith at specific sites on the cationic material, in combination with a biologically active metal salt, wherein the counter ion associated with the cationic material preferentially precipitates with at least a portion of the cation of the biologically active metal salt such that precipitation of the biologically active metal cation and the counter ion associated with the cationic material occurs in proximity to the cationic material are disclosed herein. The microbiological interception enhancing agent may be incorporated into articles of commerce by treating the starting materials of the structure or by applying the microbiological interception enhancing agent on to at least one surface of the article.

Abstract: Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocidal metallic materials non-leachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface of the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinfectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it.

Abstract: Topical preparation dispensers and methods of using the same are provided. Aspects of the invention include a topical preparation dispenser having a holder, one or more vertically stacked topical preparations in the holder, and a cap at one end of the holder configured such that upon movement of the cap, a topical preparation is exposed and moved relative to the holder. Also provided are kits that include the subject dispensers.

Abstract: Combinations of silver and copper ion sources or a single source of both silver and copper ions are found effective in methods for treating viral infections and for treating surfaces so as to eradicate viral contaminants and/or prevent subsequent contamination of said surfaces with viruses. These methods are particularly applicable in addressing SARS and avian flu viruses.

Abstract: A microbicidally coated article, especially a container, having on at least part of it a coating comprising an organically modified inorganic matrix comprising silver colloids which is obtainable by application of a coating composition comprising a) a hydrolysate or condensate based on at least one hydrolysable silane with at least one non-hydrolysable substituent and b) a silver compound to the surface of the article and treatment with heat and/or radiation to form the silver colloid coating. Articles coated in accordance with the invention are therefore particularly suitable for purposes of disinfection, preservation, cosmetic, pharmaceutical or medical purposes. Articles from the pharmaceutical or medical sector, especially containers for pharmaceuticals or articles or components which come into contact with the human body and are required to be free from germs, are preferred fields of application.

Abstract: An antimicrobial composite which comprises a first, liquid-permeable layer and a second layer arranged on the first layer. An antimicrobial metal in elemental form is present between the first and second layers and substantially no antimicrobial metal in elemental form is present on exterior surfaces of the composite. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Abstract: Prosthetic dental element is obtained by machining a rod of composite material including fibres embedded in a matrix containing resin. The matrix also contains at least one agent with an antimicrobial effect at a concentration between 0.05 and 30% by weight of the prosthetic element. The agent is in powder form.

Abstract: A dendrimer complex comprising a dendrimer and an antimicrobial agent with the dendrimer complex placeable directly into a fluid to inhibit growth of microbes or rid the fluid of microbes. In a further embodiment of the invention the dendrimer complex is secured to a carrier, which is placed in a body of fluid and allowed to dispense the antimicrobial agent into the fluid. Once the antimicrobial agent is dispensed, the dendrimer complex can be removed and recycled to add functional groups to the dendrimer so that the dendrimer can be reused.

Abstract: Antimicrobial compositions for use in locking catheters and other devices are provided. In some embodiments, the composition includes at least one alcohol, at least one biocidal agent which is not an alcohol, and one or more poloxamers; in other embodiments, the composition comprises at least one poloxamer and at least one alcohol. The composition can provide long-lasting antimicrobial activity. Methods of using the composition are also provided.

Abstract: A non-toxic environmentally friendly aqueous disinfectant is disclosed for specific use as prevention against contamination by potentially pathogenic bacteria and virus. The aqueous disinfectant is formulated by electrolytically generating silver ions in water in combination with a citric acid. The aqueous disinfectant may include a suitable alcohol and/or a detergent. The aqueous disinfectant has been shown to be very effective at eliminating standard indicator organisms such as staphylococcus aureus, salmonella cholerasuis and pseudomonas aeruginosa.