Copper Patents (Class 424/630)
  • Patent number: 7056537
    Abstract: The present invention relates to a method of abating hydrogen sulfide gas emitted by or generated in landfills. Certain embodiments of the present invention relate to contacting hydrogen sulfide gas with Fuller's earth or other carrier materials and metals such as silver, copper, iron, zinc or mixtures thereof, and other components.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 6, 2006
    Assignee: Aceto Corporation
    Inventor: Richard Weschler
  • Patent number: 7056948
    Abstract: Methods and compositions for reducing animal waste malodor using agents and cross-adapting agents are described.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: June 6, 2006
    Assignee: Monell Chemical Senses Center
    Inventors: George Preti, Charles Wysocki
  • Patent number: 7049339
    Abstract: A composition for treating a disease affecting the hoof of an animal comprising an active ingredient and a colloid former is described. The active ingredient may comprise zinc sulphate, copper sulphate, an organic acid, an alkali metal salt or a mixture thereof. The composition as disclosed has the advantage that it is more effective at applying an active ingredient to a hoof than a conventional, non-colloid system.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: May 23, 2006
    Assignee: Forty Eight Shelf (80) Limited
    Inventor: William Thomson
  • Patent number: 7041699
    Abstract: A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: May 9, 2006
    Assignee: Matthias Rath
    Inventors: Shrirang Netke, Aleksandra Niedzwiecki, Matthias Rath, Waheed M. Roomi
  • Patent number: 7034012
    Abstract: A composition of biochemical substances for the treatment of arrhythmia in a human susceptible to arrhythmia, and its method of administration, comprising at least one ascorbate compound selected from the group consisting of ascorbic acid, pharmaceutically acceptable ascorbate salts and/or mixtures thereof in combination with at least one carnitine compound selected from the group of carnitine hydrochloride, pharmaceutically acceptable carnitine salts and/or mixtures thereof.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: April 25, 2006
    Inventors: Matthias Rath, Aleksandra Niedzwiecki
  • Patent number: 7029703
    Abstract: A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: April 18, 2006
    Assignee: Metagenics, Inc.
    Inventors: Kim C. Krumhar, Holly A. Johnson
  • Patent number: 7008647
    Abstract: The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 7, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin
  • Patent number: 7005145
    Abstract: The invention relates to polymer dispersions or polymer solutions that are given antibacterial and fungicidal properties by metal ions of group Ib of the Periodic table. According to the invention, a) the polymer dispersions or polymer solutions are not produced using controllers that contain thiol groups, b) the metal ions have been introduced by means of an electrochemical process and c) said dispersions or solutions do not contain any active quantity of organic biocides.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: February 28, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Maximilian Angel, Bernhard Fussnegger, Silke Gebert
  • Patent number: 7001452
    Abstract: The present invention relates to a method and a wood preserving composition which is free of poly-aspartic acid and its derivatives and comprises mixtures of a metal compound, complexing agents selected from ethanolamines, polyethylenimine, ammonia or a mixture of these compounds, and a vinyl based polymer selected from poly(vinyl alcohol) (PVA), poly(acrylamide) (PA), poly(N-vinyl pyrrolidone) (PVP) and poly(N-isopropyl acrylamide) (PNIPAM). The resulting metal amine solution can then be used to formulate a variety of metal-based cellulosic material preserving products.
    Type: Grant
    Filed: November 11, 2004
    Date of Patent: February 21, 2006
    Assignee: Osmose, Inc.
    Inventors: Jun Zhang, Robert M. Leach, Paul Griffin
  • Patent number: 6989156
    Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: January 24, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventor: Scott H. Gillis
  • Patent number: 6979468
    Abstract: A method and composition for the treatment of acne vulgaris, acne rosacea, and other inflammatory skin conditions comprises the oral administration of a composition comprising a dose of nicotinamide delivered at levels substantially in excess of normal dietary levels, the nicotinamide being delivered in combination with zinc. The composition may also include quantities of copper and folic acid. In a most preferred embodiment, the nicotinamide and copper each are present in immediate release formats, while the zinc is present in a sustained release format.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: December 27, 2005
    Assignee: Sirius Laboratories
    Inventor: Frank Pollard
  • Patent number: 6939566
    Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: September 6, 2005
    Inventors: Kareem I. Batarseh, Marwan Al-Kayed
  • Patent number: 6939568
    Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 6, 2005
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin
  • Patent number: 6923991
    Abstract: A bactericide useful as a shelf life extender for produce and other food products. The bactericide is an aqueous solution formed from water, copper sulfate pentahydrate and a reagent, which can either be an acid or hydrogen peroxide. The bactericide is applied as a coating on the food product and is especially useful in extending the shelf life of fruits and vegetables. Other applications of the bactericide include treatment of drinking water, bacteria and algae control in pools and natural bodies of, water and as a disinfectant in cleansers.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: August 2, 2005
    Assignee: Global Microbio Products, L.L.C.
    Inventor: Francis Benjamin McLaughlin
  • Patent number: 6905711
    Abstract: An antimicrobial agent includes an oligodynamic metal ion in a hydrophilic polymer binder or carrier. According to a presently preferred embodiment, the metal ion is silver and the hydrophilic polymer is polyurethane. According to a method of the invention, the antimicrobial agent is dissolved in dimethyl acetamide DMA, applied to paper by squeegee or the like and dried in an oven to flash off the solvent. The antimicrobial agent can be applied to other products by spraying and/or dipping and then drying to flash off solvent. A method of rendering a polymeric medical device antimicrobial is also disclosed.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: June 14, 2005
    Assignee: Smart Anti-Microbial Solutions, LLC
    Inventors: Louis J. Tullo, Leonard Pinchuk
  • Patent number: 6896908
    Abstract: This invention relates to a leach-resistant borate preservative for lignocellulosic-based products, providing resistance against insect and fungal attack for use in exterior and ground contact applications. The preservative compositions of this invention may be provided as a high strength liquid concentrate, suitable for transportation, storage and easy on-site dilution, or as a ready-to-use treatment solution. These wood preservative compositions include a borate preservative component and a co-biocidal metal fixative such as copper or zinc. The preservative compositions also contain volatile organic acid, free ammonia and ammonium salts to aid dissolution. Methods for the application of these preservative compositions to wood are also provided.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: May 24, 2005
    Assignee: U.S. Borax Inc.
    Inventors: Jeffrey D. Lloyd, Jennifer L. Fogel
  • Patent number: 6897349
    Abstract: The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any desired shape for its desired uses.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: May 24, 2005
    Assignee: Acrymed
    Inventors: Bruce L. Gibbins, Lance D. Hopman
  • Patent number: 6881424
    Abstract: A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a strong oxyacid, wherein the resultant acidic composition is less corrosive to a ferrous metal than a solution of a mineral acid having the same acidic pH value as that of the acidic composition, and where in the acid composition is more biocidal than a mixture of the organic acid and a metal salt of the organic acid which mixture has the same acid normality value as that of the acidic composition. The acidic composition can be prepared by mixing at least one regenerating acid, at least one metal base, and at least one organic acid, wherein the amount of the regenerating acid is in excess of the equivalent amount of the metal base.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: April 19, 2005
    Assignee: Mionix Corporation
    Inventors: Maurice Clarence Kemp, Robert Blaine Lalum, David E. Lewis, Robert H. Carpenter
  • Patent number: 6863904
    Abstract: The present invention relates to compositions without added iron and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method involves administering to an individual a composition comprising carotenoids, vitamin E, vitamin D, vitamin C, thiamine, riboflavin, niacin, folic acid, pyridoxine, biotin, pantothenic acid, cobalamin, magnesium, manganese, zinc, selenium, chromium, copper, alpha lipoic acid, and lutein, wherein the composition is free of added iron.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: March 8, 2005
    Assignee: Everett Laboratories, Inc.
    Inventors: John A. Giordano, Charles Balzer
  • Patent number: 6855340
    Abstract: The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 15, 2005
    Assignee: Regents of the University of Michigan
    Inventor: George J. Brewer
  • Patent number: 6852329
    Abstract: An effective, readily ingested molluscicidal bait poison includes a mollusc bait and a second component. The second component can contain a transition metal compound and a complexing agent, and/or the complex of a transition metal compound and a complexing agent. The complexing agent is preferably iminodisuccinic acid (IDS), including sodium IDS (IDS Na-Salt), iminodifumaric acid (IDF), iminoditartaric acid (IDT), iminodimaleic acid (IDMAL), ethylenediaminedifumaric acid (EDDF), ethylenediaminedimalic acid (EDDM), iminodimalic acid (IDM), ethylenediamineditartaric acid (EDDT), ethylenediaminedimaleic acid (EDDMAL), and salts thereof.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 8, 2005
    Assignee: W. Neudorff GmbH KG
    Inventors: George S. Puritch, Andreas Prokop, David S. Almond, Robert Matson
  • Patent number: 6849276
    Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: February 1, 2005
    Assignee: Action Pin
    Inventors: Ghislain Dufau, Michel Barsacq, Gérard Molla
  • Patent number: 6844012
    Abstract: The invention concerns the use of at least a molecule containing selenium, in an amount corresponding to a daily dose of about 2 to 40 mg, even 80 mg of atomic selenium equivalent, on its own or combined with other synergetic molecules for controlling oxidative stress and excessive inflammatory reaction: zinc, vitamin E, vitamin C, iron binder, glutathione precursor, copper and/or copper input binder, for preparing a medicine for treating severe systemic inflammatory response syndrome, in particular any acute infectious condition endangering the patient's life whether of bacterial, parasitic, fungal or viral origin, and any condition corresponding to a severe onset of inflammatory pathology bringing about an exacerbation of cytokine secretion. The invention is applicable in human and veterinary medicine.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: January 18, 2005
    Inventors: Xavier Forceville, Dominique Vitoux
  • Patent number: 6843837
    Abstract: The present invention relates to a method and a wood preserving composition which comprises mixtures of a metal compound, complexing agents selected from ethanolamines, polyethylenimine, ammonia or a mixture of these compounds, and a vinyl based polymer selected from poly(vinyl alcohol) (PVA), poly(acrylamide) (PA), poly(N-vinyl pyrrolidone) (PVP) and poly(N-isopropyl acrylamide) (PNIPAM). The resulting metal amine solution can then be used to formulate a variety of metal-based cellulosic material preserving products.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: January 18, 2005
    Assignee: Osmose, Inc.
    Inventors: Jun Zhang, Robert Leach, Paul Griffin
  • Publication number: 20040258768
    Abstract: A wood preservative includes injectable particles comprising one or more sparingly soluble copper salts. The copper-based particles are sufficiently insoluble so as to not be easily removed by leaching but are sufficiently soluble to exhibit toxicity to primary organisms primarily responsible for the decay of the wood. Exemplary particles contain for example copper hydroxide, basic copper carbonate, copper carbonate, basic copper sulfates including particularly tribasic copper sulfate, basic copper nitrates, copper oxychlorides, copper borates, basic copper borates, and mixtures thereof. The particles typically have a size distribution in which at least 50% of particles have a diameter smaller than 0.25 &mgr;m, 0.2 &mgr;m, or 0.15 &mgr;m. At least about 20% and even more than 75% of the weight of the particles may be composed of the substantially crystalline copper salt. Wood or a wood product may be impregnated with copper-based particles of the invention.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 23, 2004
    Inventors: H. Wayne Richardson, Robert L. Hodge
  • Publication number: 20040258767
    Abstract: The present invention provides wood preservative compositions comprising micronized particles. In one embodiment, the composition comprises dispersions of micronized metal or metal compounds. In another embodiment, the wood preservative composition comprises an inorganic component comprising a metal or metal compound and organic biocide. When the composition comprises an inorganic component and an organic biocide, the inorganic component or the organic biocide or both are present as micronized particles. When compositions of the present invention are used for preservation of wood, there is minimal leaching of the metal and biocide from the wood.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 23, 2004
    Inventors: Robert M. Leach, Jun Zhang
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Publication number: 20040253319
    Abstract: The present invention provides pharmaceutical compositions for alleviating pathological conditions in a post-menopausal woman, comprising lysine, proline, arginine, ascorbic acid, magnesium, green tea extract, N-acetyl-cysteine, selenium, copper, manganese and one pharmaceutical acceptable component selected from the group consisting of a carrier, a diluent, and an excipient, wherein the compositions contain 24-25 wt % lysine, 16-25 wt % ascorbic acid and 22-25 wt % green tea extract. A method of treatment using the pharmaceutical compositions are also disclosed.
    Type: Application
    Filed: June 11, 2003
    Publication date: December 16, 2004
    Inventors: Shrirang Netke, Aleksandra Niedzwiecki, Matthias Rath, Vadim Ivanov
  • Patent number: 6827943
    Abstract: Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: December 7, 2004
    Assignee: Bradley Pharmaceuticals, Inc.
    Inventors: Bradley P. Glassman, Dileep Bhagwat, Daniel Glassman
  • Publication number: 20040224005
    Abstract: The invention provides an antimicrobial and antiviral polymeric material, having microscopic particles of ionic copper encapsulated therein and protruding from surfaces thereof.
    Type: Application
    Filed: December 16, 2002
    Publication date: November 11, 2004
    Applicant: The Cupron Corporation
    Inventor: Jeffrey Gabbay
  • Patent number: 6814983
    Abstract: The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or lactating subjects.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: November 9, 2004
    Assignee: Everett Laboratories, Inc.
    Inventors: John A. Giordano, Charles Balzer
  • Patent number: 6794414
    Abstract: Diseases Mediated by transglutaminase, such as Huntington's Disease, spinobulbar atrophy, spinocerebellar ataxia, and dentatorubralpallidoluysian atrophy, as well as inflammatory diseases of the central nervous system, including mautiple sclerosis, rheumatoid arthritis, and insulin dependent diabetes mellitus, can be treated by administering a transglutaminase inhibitor such as monadansyl cadaverine, monoamines and diamines such as cystamine, putrescine, GABA. (gamma-amino benzoic acid), N-benzyloxy carbonyl, 5-deazp-4-oxonorvaline p-nitrophenylester, glycine methyl ester, CuSO4, and the oral anti-hyperglycemic agent tolbutamide.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: September 21, 2004
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Lawrence Steinman
  • Publication number: 20040180006
    Abstract: Methods and compositions are provided for blocking the calcium cascade. More particularly, compositions and methods are provided that inhibit histamine reactions triggered by the calcium cascade, using the naturally occurring pH gradients in the body to deliver therapeutic doses of metal ions which block the calcium cascade.
    Type: Application
    Filed: December 15, 2003
    Publication date: September 16, 2004
    Inventor: Nicholas A. Sceusa
  • Patent number: 6790463
    Abstract: The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimithyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: September 14, 2004
    Inventors: Robert F. Hofmann, Robert H. Carpenter
  • Publication number: 20040175433
    Abstract: A composition for treating a disease affecting the hoof of an animal comprising an active ingredient and a colloid former is described. The active ingredient may comprise zinc sulphate, copper sulphate, an organic acid, an alkali metal salt or a mixture thereof. The composition as disclosed has the advantage that it is more effective at applying an active ingredient to a hoof than a conventional, non-colloid system.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 9, 2004
    Inventor: William Thomson
  • Publication number: 20040175432
    Abstract: Metallic comb for dosing copper salts to the user. The comb can be pure copper metal or an alloy which can include at least one of copper, antimony, nickel, silver and arsenic. Normal use of the comb provides a residuum of copper salts to be deposited in the hair.
    Type: Application
    Filed: March 6, 2003
    Publication date: September 9, 2004
    Inventor: Victor Alejandro ESCUDERO GACITUA
  • Patent number: 6780332
    Abstract: A water treating system utilizes antimicrobial sand filter for killing bacteria and preventing microbial growth. Said antimicrobial sand filter consists of organic quaternary ammonium salt and inorganic metal compound.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: August 24, 2004
    Assignee: Parker Holding Services Corp.
    Inventors: Yen-Kuen Shiau, Chung-Hsun Wu, Vincent T Chuang
  • Patent number: 6776979
    Abstract: An oral compound of water; glycerin; a cranberry source; methylsulfonylmethane; melaleuca alternifolia oil; hydroxyethylcellulose; and a surfactant, in proper combination for use by injecting the compound around a person's gum line followed by its use in a dental tray over a person's teeth and gums for a specified period of time. The next phase to the overall treatment regimen is a daily health care regimen involving: a systemic immune defense compound having colostrum beta 1,3 Glucans; fructo-oligosaccharides; amla fruit 4:1; inositol hexaphosphate; selected minerals; selected enzymes; selected probiotics; and methylsulfonylmethane; an antimicrobial compound having sodium bicarbonate, silicone dioxide, and a cranberry source; and an oral probiotic compound having selected probiotics; vitamin C; and colostrum.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: August 17, 2004
    Inventors: Marvin B. Frager, R. Douglas Gaynor, John R. Taylor
  • Publication number: 20040157073
    Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Applicant: Nucryst Pharmaceuticals Corp., a Alberta, Canada corporation
    Inventors: Robert Edward Burrell, Hua Qing Yin, Antony George Naylor, Peter Howard Moxham, Walter Carlton Theodore Cholowski, Leonard Salvin Bowlby, David James Field
  • Patent number: 6774111
    Abstract: The two carbohydrate mixture of this invention utilizes a source of fructose in combination with at least one readily digestible glucose polymer source. The addition of the fructose significantly decreases the glycemic response when compared to the digestible glucose polymer alone. Additional components may be added to the simple two component carbohydrate mixture to form a carbohydrate system suitable for incorporation into an enteral nutritional. This carbohydrate system optionally incorporates nonabsorbent carbohydrates, dietary fiber and indigestible oligosaccharides. The present invention is also directed to an enteral nutritional which incorporates the two component carbohydrate mixture and less than 37% of calories from fat. Additionally, the invention is directed to a method of delivering nutrients to a person with diabetes by feeding the enteral nutritional.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: August 10, 2004
    Assignee: Abbott Laboratories
    Inventors: Bryan W. Wolf, Bradley A. Zinker, Keith A. Garleb, Joseph E. Walton
  • Patent number: 6764692
    Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: July 20, 2004
    Inventor: Carlos Cortelezzi
  • Patent number: 6756063
    Abstract: Methods and compositions for altering the viability of cells, particularly cancers in animals and humans are disclosed. The compositions of the present invention are formed from a set of components comprising one or more of the following: a dithiocarbonyl, preferably dithiocarbamate, compound; a divalent metal ion; a modulator of cellular glutathione levels; and an inhibitor of the phosphorylation of choline. The compositions described herein induce a relatively selective and rapid effect on the viability of cancer cells by inducing a mixture of apoptotic and necrotic cell death, with the dominant pathway being apoptosis. Particularly preferred active compositions comprise all four components, although combinations of fewer components can be fully effective in certain tumors.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: June 29, 2004
    Assignee: Zoltan Laboratories, LLC
    Inventor: Zoltan Kiss
  • Patent number: 6743191
    Abstract: The invention relates to a substitution infusion fluid for hemofiltration of a specific composition. The use of said substitution infusion fluid significantly reduces the risk of the occurrence of abnormalities in a patient undergoing pure hemofiltration. The invention also relates to process for pure hemofiltration of blood wherein said substitution infusion fluid is used. The invention also relates to a matching citrate anticoagulation fluid of a specific composition. The invention also relates to a process for pure hemofiltration of blood wherein said substitution infusion fluid is used in combination with said citrate anticoagulation fluid. The use of said substitution infusion fluid in combination with said citrate anticoagulation fluid significantly further reduces the risk of the occurrence of abnormalities in a patient undergoing pure hemofiltration.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: June 1, 2004
    Assignee: Edwards Lifesciences AG
    Inventor: Pe Chou Chang
  • Publication number: 20040101572
    Abstract: Te invention relates to a microbial control system for treating influent water and sump water for control of microbial material in machines which process water such as ice making machines, humidifiers such as cool mist humidifiers and cooling towers. The microbial control system includes antimicrobial treatment media housed in a containment vessel. The treatment media can include any one or more of transition metals and transition metal oxides. The transition metal may be any of Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Rf, Db, Sg, Bh, Hs, Mt, Uun, Uuu and Uub.
    Type: Application
    Filed: March 5, 2003
    Publication date: May 27, 2004
    Inventors: Bryan E. Kepner, Sherman M. Ponder
  • Patent number: 6726937
    Abstract: The present invention provides use of a composition containing 2-n-octyl-4-isothiazolin-3-one and N-n-butyl-1,2-benzisothiazolin-3-one for providing antifungal efficacy to a wood preservative containing copper oxide or a copper salt and a fungicidal azole. It also provides a wood preservative which comprises 2-n-octyl-4-isothiazolin-3-one, N-n-butyl-1,2-benzisothiazolin-3-one, copper oxide or a copper salt, and a fungicidal azole as active ingredients.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: April 27, 2004
    Assignee: Shinto Fine Co., Ltd.
    Inventor: Hiroshi Imai
  • Patent number: 6723350
    Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: April 20, 2004
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin, Antony George Naylor, Peter Howard Moxham, Walter Carlton Theodore Cholowski, Leonard Salvin Bowlby, David James Field
  • Publication number: 20040067156
    Abstract: A new, novel and useful disinfection and purification system comprised of organic compounds in synergistic action with selected metal ions and method of manufacture and use. One of the benefits that is derived from this system is the ability to quickly and easily treat a surface, fluid or medium for disinfection of bacteria, fungi, viruses, algae and protozoans, with a non-toxic, non-chlorinated mixture that effectively kills all such organisms in minutes or hours. The disinfection and purification system remains effective for long periods of time maintaining its disinfection capacity making it highly effective for stored or transported mediums such as potable drinking water. The disinfection and purification system may be incorporated with carbon block or membrane filters to disinfect filtered liquids such as water to render it potable.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 8, 2004
    Inventor: Bradley J. Eldred
  • Patent number: 6716458
    Abstract: The is invention is directed to a composition useful for assisting in supplying a warm-blooded animal with many of its nutritional needs. More specifically, this invention is directed to a composition whereby many of the vitamins, minerals, amino acids and cofactors are suspended in a matrix which when administered to a mammal provides substantial benefit.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: April 6, 2004
    Inventor: Bryon J. Tarbet
  • Patent number: 6715618
    Abstract: A water treating system utilizes antimicrobial sand filter for killing bacteria and preventing microbial growth. Said antimicrobial sand filter consists of organic quaternary ammonium salt and inorganic metal compound.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 6, 2004
    Assignee: Parker Holding Services Corp.
    Inventors: Yen-Kuen Shiau, Chung-Hsun Wu, Vincent T Chuang
  • Patent number: 6696083
    Abstract: The efficacy of vitamins and other nutritional agents in treating and preventing various disease states is improved by administering therapeutically effective levels of these agents on a substantially continuous, 24-hour basis. The concentration of lipid peroxides formed by the autoxidation of lipids, and the concentration of oxygen free radicals, are reduced by continuously administering antioxidant agents. The regeneration of nerve tissue is improved by continuously administering at least one pharmaceutically-acceptable B complex vitamin.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: February 24, 2004
    Assignee: DrugTech Corporation
    Inventors: George N. Paradissis, R. Saul Levinson, Mitchell I. Kirschner, Marc S. Hermelin