Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.

Abstract: An antibacterial titania comprising a titania to which ions of an antibacterial metal are adhered, wherein the antibacterial metal is silver; and the antibacterial titania further contains chlorine at a Cl/Ag molar ratio in a range of from 2.8 to 7.2. A process for producing an antibacterial titania which comprises the steps of: (1) incorporating a salt of an antibacterial metal into a slurry of metatitanic acid to adhere ions of the antibacterial metal to titania in the metatitanic acid slurry; and (2) adding a source of chlorine ions to the slurry, wherein the antibacterial metal is silver.

Abstract: A pharmaceutical composition having buffering properties comprises as its primary ingredients calcium carbonate (CaCO.sub.3) and magnesium oxide (MgO; magnesia) that form the base for the compound. Potassium sorbate (CH.sub.3 CH: CHCH:CHCOOK) is provided as a preservative. Other ingredients include a tabletizing binder, vitamin complexes, minerals as antipathogens, and flavorings.

Abstract: The invention relates to oral care compositions with colloidal anti-plaque agents which have been coated with particular polymers containing carbohydrate (saccharide) or peptide structures which are specifically recognised by bacterial adhesins, more particularly carbohydrate containing polymers recognized by bacterial lectins, or with antibodies or antibody fragments which recognize plaque bacterial antigens. Such coated colloidal anti-plaque agents, e.g. coated colloidal zinc oxide, can be target to specific sites in the human mouth where the anti-plaque agent is then released at acidic pH.

Abstract: Aqueous pharmaceutical solutions suitable for injection into a host, having improved injection site toleration, comprise danofloxacin or its pharmaceutically acceptable salts and a magnesium or zinc compound. The zinc compound in addition requires the presence of a co-solvent.

Abstract: The present invention relates to a method of supplementing the dietary needs of women whereby an effective amount of a life stage appropriate dietary supplement is administered to a woman at each of her life stages throughout her life.

Abstract: A feed fortifier and enhancer for preruminant, bovine calves comprising animal plasma as well as other ingredients. The feed fortifier and enhancer may be mixed with any liquid feed to be fed to preruminant calves.

Abstract: A method of reducing oral malodor includes providing a solution of sodium chlorite and a metal ion capable of complexing with sulfur and applying the solution as mouth rinse.

Abstract: The present invention provides an oil-based, anti-plaque dentifrice comprising vitamin E and an enzyme in an admixture which is effective to dissolve plaque and to resist plaque formation. The preferred dentifrice composition is substantially anhydrous, and includes a chelating agent and a promoter to assist the enzyme in fighting plaque.

Abstract: Methods of virucidal disinfection with virucidal disinfectants containing an active quantity of salts of metals of the alkaline earth metals, alkali metals, earth metals and/or metals of the first, second or third secondary group of the periodic system of elements in the form of a solution in water and/or alcohol are provided. The virucidal activity of alcohols or alcohol/water mixtures with a total alcohol concentration of 40 to 90% and preferably 50 to 80% can be considerably increased by addition of base- or acid-hydrolyzed salts of metal ions of the earth metal and meta metal group of the periodic system of elements in quantities of 0.1 to 1% by weight and preferably in quantities of 0.2 to 0.6% by weight. Normally ineffectual alcohol mixtures or alcohol/water mixtures thus develop far-reaching virucidal activity. The disinfectants may also contain small quantities of substances for improving compatibility with the skin, wetting agents and corrosion inhibitors.

Abstract: The present invention provides a method of controlling bacteria or fungi which comprises contacting therewith a zinc compound and at least one member selected from among hinokitiol and salts thereof; a method of treating infectious diseases caused by bacteria or fungi which comprises administering a zinc compound and at least one member selected from among hinokitiol and salts thereof; and a method of preserving cosmetics which comprises adding thereto a zinc compound and at least one member selected from among hinokitiol and salts thereof.

Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.

Abstract: A composition for relieving stress, anxiety, grief, and depression includes GABA (gamma amino butyric acid), glutamine, glycine, magnesium, passion flower, primula officinalis, and vitamin B-6.

Abstract: The present invention relates to dietary supplements for supplementing the dietary needs of women and preventing or reducing life stage associated health risks during each of their principal adult life stages (pre-perimenopause, perimenopause and menopause, or post-menopause).

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: A nutritional composition, adapted for consumption by mammals, contains (1) an orally ingestible diluent or carrier, except an oily carrier or diluent which comprises C.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, and (2) a composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from linolenic acid and its salts, esters and amides, calculated as the free acid, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from linoleic acid and its salts, esters and amides thereof, calculated as the free acid, the salts, esters and amides of linolenic and linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable. The invention also relates to a method for treating a mammal for the purpose of inducing therein at least one physiological effect selected from memory enhancement and analgesia, by administration of an effective amount of the nutritional composition.

Abstract: A composition containing a water soluble or water swellable polyelectrolyte mixed salt in a dentifrice base or other oral compositions which can be used for relieving pain and discomfort caused by hypersensitive teeth.

Abstract: A microgranular preparation having a core of biologically active material that is encapsulated by a water soluble film that is covered by an enteric coating of either an alkali soluble, acid insoluble polymer or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acids or other material capable of being solubilized by intestinal juices. Useful for protecting pH sensitive and other biologically active materials from inactivation or contact with the stomach or rumen, and releasing the same in active form in the intestinal tract, particularly the duodenum.

Abstract: The present invention involves a method of preparing a nutritional product in which a powder base containing fats, carbohydrates, vitamins, minerals and trace elements is mixed with specific amino acids to yield several different therapeutic products for use in the nutritional support of infants or toddlers having various inherited metabolic diseases.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in increasing the immunity and decreasing the instances and severity of infection particularly among older persons.

Abstract: A composition for a dietary supplement includes: 12.5 to 25% pumpkin seeds by weight; 1,875 to 18.75% extract of Serenoa repens by weight; 6.25 to 12.5% Pygeum africanum by weight; 3.125 to 6.25% zinc glycinate by weight; 3.125 to 9.375% magnesium by weight; and 9,375 to 18.75% vitamin E acetate by weight. The composition may further include Di-Tab, Syloid and magnesium stearate as excipients.

Abstract: The present invention relates to the use of Triclosan in the manufacture of a composition for the prevention, inhibition and/or reduction of aphthous ulcers. Preferably, the compositions are oral compostions such as toothpastes and mouthwashes. The oral composition is especially preferably in a gel form. Preferably the Triclosan is used together with a zinc salt such as zinc citrate, and or a polymer that enhances the delivery of the Triclosan.

Abstract: This invention provides a co-micronized bicarbonate salt composition which is a blend of ingredients having a particle size between about 0.01-1.0 micron. The composition is produced by mill co-micronization of a crystalline bicarbonate ingredient and a crystalline inorganic compound ingredient having a Mohs hardness value between about 3-7. A co-micronized blend such as sodium bicarbonate and zinc oxide is free-flowing and essentially free of agglomerated particles.

Abstract: This invention provides a mouthwash composition which is in the form of a concentrated aqueous ethanolic formulation of ingredients. An essential aspect of an invention mouthwash is an alkali metal bicarbonate ingredient which is present as a suspension phase of ultrafine particles. The suspension phase also can have a content of colloidal zinc oxide. Oral hygiene is practiced by diluting an invention mouthwash concentrate with water, and rinsing the oral cavity with the diluted liquid medium.

Abstract: The present invention relates to hypertonic crystalloid resuscitation fluids particularly useful in treating hemorrhagic shock. A pharmaceutical formulation prepared and selected ratios of sodium chloride and sodium acetate with a total osmolar concentration exceeding 500 mOsm can be used as a small volume resuscitation fluid which has little effect on plasma chloride levels. Arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs with a significant increase in oxygen delivery and consumption.

Abstract: This invention provides a co-micronized bicarbonate salt composition which is a blend of ingredients having a particle size between about 0.01-1.0 micron. The composition is produced by mill co-micronization of a crystalline bicarbonate ingredient and a crystalline inorganic compound ingredient having a Mohs hardness value between about 3-7. A co-micronized blend such as sodium bicarbonate and zinc oxide is free-flowing and essentially free of agglomerated particles.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives or linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.

Abstract: A composition of matter comprising zinc and an extract of animal prostatic tissue provides a convenient source of both fatty acids and zinc for dietary and therapeutic purposes. The pharmaceutical composition is useful for the treatment of diabetes.

Abstract: The pharmaceutical composition according to the invention consists essentially of:i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium, manganese, iron, cobalt, nickel, copper, zinc and molybdenum, which compounds do not precipitate with each other or with the other components of the composition and exhibit a neutral or acidic pH in an aqueous medium;ii) glycine;iii) glycerol;iv) L-(+)-ascorbic acid;v) succinic acid;vi) a neutral or acidic and water-soluble, pharmaceutically acceptable salt of ethylenediamine tetraacetic acid;vii) potassium sodium tartrate; andviii) L-(+)-tartaric acid. The composition can be used for the treatment of mucoviscidosis and chronic pain syndromes deriving from locomotor diseases or accompanying diseases of tumorous origin.

Abstract: A method for chemically castrating male pigs in a manner that modulates the production of testosterone and interferes with the enzymatic conversion of testosterone into androstenone by injecting a mineral acetate solution into both testes or epididymides in an amount effective to reduce the pig's serum testosterone level below that of an intact male.

Abstract: A microgranular preparation having a core of biologically active material that is encapsulated by a water soluble film that is covered by an enteric coating of either an alkali soluble, acid insoluble polymer or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acids or other material capable of being solubilized by intestinal juices. Useful for protecting pH sensitive and other biologically active materials from inactivation or contact with the stomach or rumen, and releasing the same in active form in the intestinal tract, particularly the duodenum.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: A nutritional supplement, functioning as a food for special dietary use, enhances diets and assists persons recovering from addiction to health damaging substances. Since cellular damage and deficiencies occur and continue to exist even after the person has stopped abusing the substances, use of the nutritional supplement, which contains a variety of minerals, vitamins, herbs, amino acids, and other substances and nutrients, should be continuous. The nutritional supplement consists of a mixture of nutrients which cooperate synergistically in enhancing cellular metabolic pathways and assists in normalization of cellular functions and optimization of cellular health.

Abstract: The pharmaceutical composition according to the invention consists essentially of:i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium, manganese, iron, cobalt, nickel, copper, zinc and molybdenum, which compounds do not precipitate with each other or with the other components of the composition and exhibit a neutral or acidic pH in an aqueous medium;ii) glycine;iii) glycerol;iv) L-(+)-ascorbic acid;v) succinic acid;vi) a neutral or acidic and water-soluble, pharmaceutically acceptable salt of ethylenediamine tetraacetic acid;vii) potassium sodium tartrate; andviii) L-(+)-tartaric acid. The composition can be used for the treatment of mucoviscidosis and chronic pain syndromes deriving from locomotor diseases or accompanying diseases of tumorous origin.

Abstract: A nutritional supplement, functioning as a food for special dietary use, enhances diets and assists persons recovering from addiction to health damaging substance(s). Since cellular damage and deficiencies occur and continue to exist even after the person has stopped abusing the substance(s), use of the nutritional supplement, which contains at least one enzyme activating substance and at least one enzyme cofactor, should be continuous. The nutritional supplement consists of a mixture of nutrients which cooperate synergistically in enhancing cellular metabolic pathways and assists in normalization of cellular functions and optimization of cellular health.

Abstract: A method of enhancing a magnetic resonance signal comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the naturally occurring concentration of such isotope and detecting magnetic resonance signal from the administered magnetic isotope in the living biological tissue.

Abstract: The present invention relates to a hypertonic crystalloid resuscitation fluid particularly useful in treating circulatory shock arising from loss of blood. A pharmaceutical formulation prepared from sodium chloride in a range of about 2-7 osmolar parts and sodium acetate in a range of about 1-2 osmolar parts where the total osmolar concentration exceeds 500 mOsm can be used as a small volume rapid bolus resuscitation fluid which has little effect on plasma chloride levels. Blood flow is improved while arterial pressure is improved to the point of sustaining oxygen supply to tissues and organs in the recumbent recipient.

Abstract: A method of treating the prostate by intraprostatic injection of zinc ions in a concentration effective to increase the amount of prostatic antibacterial factor and to inhibit the rate of prostatic growth. The treatment is applied to patients with prostatitis, to patients with benign adenomatous hyperplasia of the prostate after prostatic resection and to patients with early prostatic carcinoma as an alternative to surgery as needed to provide long-term remission. The treatment is also applied prophylactically to prevent the development of prostatitis, particularly in males of advanced age.

Abstract: A process for treating antigen solutions with an adjuvant is described, in which process a zinc hydroxide/calcium hydroxide gel and, where appropriate, additionally a lecithin and, where appropriate, additionally a polyalphaolefin is added to the antigen solution.

Abstract: The present invention relates to oral effervescent dosage forms for the administrations of an intended ingredient to children, and processes for their administration.

Abstract: Oral composition containing an oil-in-water emulsion, wherein the oil phase of the emulsion includes an aminoalkyl silicone and a lipophilic compound and the aqueous phase includes an emulsifier. The lipophilic compound is soluble in the aminoalkyl silicone. Preferably, a lipophilic antimicrobial agent or a lipophilic flavorant is employed. The aminoalkyl silicone forms a substantive film on the teeth surface and the lipophilic compound is deposited, along with the aminoalkyl silicone, on the teeth surface. Thus, the enhanced deposition of the lipophilic compound is attained. The pH of the compositions is preferably at least 7.0. The compositions are preferably applied by brushing.

Abstract: Ammonium and alkali metal zinc lactate complexes used in oral compositions such as gingival and subgingival irrigating solutions, dentifrices, mouthwashes, and the like as well as in other preparations for treating oral lesions.

Abstract: A sterile injectable mixture which intensifies and localizes radio frequency thermotherapy; the injectable mixture contains finely ground ferrite particles in a viscid aqueous suspension, the ferrite being matched for maximum radio frequency absorption at a specific frequency. A chemotherapeutic agent, a surfactant and a bioacceptable hydrophic colloid are also contained in the mixture.

Abstract: Alkali metal zinc gluconate complexes used in oral compositions such as gingival and subgingival irrigating solutions, dentifrices, mouthwashes, and the like as well as in other preparations for treating oral lesions.

Abstract: Thermally, chemically and flavor stable compositions for oral absorption by a human containing zinc acetate with a consumable, sweet pharmaceutical carrier and prepared in the form of a pleasant testing lozenge, powder, liquid or chewable composition for delivery of zinc to the oral and oral pharyngeal mucosa of a human with said composition being absent the normal offensive aftertaste of zinc, and being primarily intended for use in treating common colds or in nutritional supplementation.

Abstract: A pharmaceutical preparation for oral or transdermal treatment of wounds, damaged tissue and inflammation which is a solution containing water and metallic trace elements or salts thereof in a physiological quantity.

Abstract: The invention provides a pharmaceutical composition comprising a zinc complex of desferrioxamine or penicillamine as active ingredient therein in combination with a pharmacologically acceptable carrier.