Alkali Metal Or Alkaline Earth Containing Patents (Class 424/722)
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Publication number: 20040022877Abstract: A method is provided for administering to an individual a soy fortified orange juice composition which includes soy protein that readily dissolves in orange juice and does not unacceptably negatively impact sensory, mouth feel and viscosity attributes of the orange juice component. When administered daily, these compositions enhance cardiovascular health indicators in the individual. The cardiovascular health indicators include cholesterol levels and blood pressure readings for the individual so treated.Type: ApplicationFiled: July 30, 2002Publication date: February 5, 2004Inventors: Nancy Green, Richard N. McArdle, Carla McGill, Renee Mellican, Kristin Parshall
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Publication number: 20040022745Abstract: The subject invention provides a detergent composition comprising an effective amount of a soluble potassium salt, a sodium (C8-C24) alkylsulfate in an amount effective to remove or loosen debris and/or stains from a surface, and a polar surfactant, said surfactant comprising a hydrophobic portion selected from a (C6-C30) alkyl group and a polymeric silicone group, wherein the molar ratio of the surfactant to the sodium (C8-C24) alkylsulfate is greater than or equal to about 1:1. Detergent compositions of the invention include oral compositions for removing and loosening plaque and/or stains from a dental surface and oral compositions for reducing dental nerve and/or dentin sensitivity.Type: ApplicationFiled: July 30, 2003Publication date: February 5, 2004Inventors: Dennis G. A. Nelson, Andrew R. Gallopo
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Patent number: 6673375Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.Type: GrantFiled: January 14, 2002Date of Patent: January 6, 2004Assignee: Barodon-S.F. Corp.Inventors: Soo-Il Choi, Hyun-Suk Choi, Kyung-Soo Jeon, Byung-Woo Yoo, Yong-Ho Park
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Patent number: 6673358Abstract: Wet wipes impregnated with a solution which includes a mono alkyl phosphate are described. In particular, the solution in the wet wipes includes a phosphate ester surfactant which includes a mono alkyl phosphate having the following structural formula: wherein R represents a saturated or unsaturated hydrocarbon group having an average of from 8 to 22 carbon atoms, x represents a number of 0 to 20, and each of Y and Z represents hydrogen, an alkali metal, ammonium or an alkanol amine. Such wet wipes have improved tactile properties and cleaning efficacy without excessive skin irritation or foaming when compared to conventional wet wipes.Type: GrantFiled: December 16, 1999Date of Patent: January 6, 2004Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Douglas Bryan Cole, Katherine Denise Stahl
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Publication number: 20030235627Abstract: Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat human papilloma virus infections, particularly cutaneous warts.Type: ApplicationFiled: June 21, 2002Publication date: December 25, 2003Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
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Publication number: 20030235629Abstract: An improved dietary and/or therapeutic supplement composition comprising a quantity of a dietary and/or therapeutic supplement agent having a pH that upon ingestion with food or a beverage would limit the effectiveness of the agent and a sufficient amount of an electrolyte additive is provided in combination with the agent to raise the pH of the composition to a level of from about 8 to about 12.5 to increase the effectiveness of the agent upon ingestion of the composition along with a meal or a beverage. In a preferred composition, the electrolyte additive is selected from the group consisting of calcium, magnesium and potassium electrolytes. The supplement composition may be in the form of tablet, capsule, powder or liquid forms. The supplement composition is designed to provide for optimum utilization of a dietary and/or therapeutic supplement agent when taken orally with food or a beverage.Type: ApplicationFiled: July 22, 2003Publication date: December 25, 2003Inventors: Janmarie Hornack, Lawrence E. Dorman
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Topical administration of pharmacologically active bases in the treatment of inflammatory dermatoses
Publication number: 20030235626Abstract: Provided are methods and topical pharmaceutical formulations for the treatment of inflammatory dermatoses. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations are particularly suited to the treatment of acne vulgaris.Type: ApplicationFiled: June 21, 2002Publication date: December 25, 2003Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu -
Patent number: 6656505Abstract: An aqueous pharmaceutical composition suitable for oral delivery has an insoluble active substance and a wetting agent in liquid suspension. The composition contains floccules of the active ingredient. The formulation has an excellent shelf-life in which caking and sedimentation are inhibited. The composition may be resuspended upon light to moderate shaking.Type: GrantFiled: July 21, 2000Date of Patent: December 2, 2003Assignee: Alpharma USPD Inc.Inventors: Subhas Kundu, Vivek Desai, Andrea Cameron
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Publication number: 20030219483Abstract: The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-psychotic agent in a rapid release external coat. A wide range of anti-psychotic agents can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather compression-coated onto the device. The device with spray-coated external core is smaller and easier to swallow than the similar device having a compression-coated external coat. The device is useful for the treatment of depression, anxiety or psychosis related disorders.Type: ApplicationFiled: February 26, 2003Publication date: November 27, 2003Inventors: Joaquina Faour, Juan Vergez
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Patent number: 6653519Abstract: Compositions and methods for destroying biological agents such as toxins and bacteria are provided wherein the substance to be destroyed is contacted with finely divided metal oxide or hydroxide nanocrystals. In various embodiments, the metal oxide or metal hydroxide nanocrystals have reactive atoms stabilized on their surfaces, species adsorbed on their surfaces, or are coated with a second metal oxide. The desired metal oxide or metal hydroxide nanocrystals can be pressed into pellets for use when a powder is not feasible. Preferred metal oxides for the methods include MgO, SrO, BaO, CaO, TiO2, ZrO2, FeO, V2O3, V2O5, Mn2O3, Fe2O3, NiO, CuO, Al2O3, SiO2, ZnO, Ag2O, [Ce(NO3)3—Cu(NO3)2]TiO2, Mg(OH)2, Ca(OH)2, Al(OH)3, Sr(OH)2, Ba(OH)2, Fe(OH)3, Cu(OH)3, Ni(OH)2, Co(OH)2, Zn(OH)2, AgOH, and mixtures thereof.Type: GrantFiled: April 3, 2001Date of Patent: November 25, 2003Assignee: Nanoscale Materials, Inc.Inventors: Olga Koper, Kenneth J. Klabunde, Lisa S. Martin, Kyle B. Knappenberger, Laura L. Hladky, Shawn P. Decker
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Publication number: 20030215430Abstract: This invention relates to a method and compositions for the treatment and prevention of disorders associated with endothelial dysfunction consisting of anti-inflammatory agents and dietary supplements.Type: ApplicationFiled: May 14, 2003Publication date: November 20, 2003Inventor: Edward J. Petrus
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Publication number: 20030206967Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.Type: ApplicationFiled: April 25, 2003Publication date: November 6, 2003Applicant: BARODON-S.F. CORP.Inventors: Soo-Il Choi, Hyun-Suk Choi, Kyung-Soo Jeon, Byung-Woo Yoo, Yong-Ho Park
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Patent number: 6630172Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.Type: GrantFiled: January 22, 2001Date of Patent: October 7, 2003Inventor: Kareem I. Batarseh
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Publication number: 20030185900Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.Type: ApplicationFiled: April 25, 2003Publication date: October 2, 2003Applicant: BARODON-S.F. CORP.Inventors: Soo-Il Choi, Hyun-Suk Choi, Kyung-Soo Jeon, Byung-Woo Yoo, Yong-Ho Park
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Patent number: 6627229Abstract: An antiviral agent of an antiviral ability against various viruses and a method of producing the same are provided. A heat treatment is applied to a calcium-containing substance represented by calcium carbonate-containing substances originating from the animal such as clamshell, eggshell, crustacean shell, bone, coral, and pearl, and calcium carbonate-containing minerals such as limestone. When a temperature of the heat treatment is not less than 650° C. and less than a melting point of the calcium component-containing substance, a sufficient time of the heat treatment is 2 to 13 hours.Type: GrantFiled: June 23, 2001Date of Patent: September 30, 2003Inventors: Kazutomo Kikuchi, Noriaki Kikuchi
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Publication number: 20030170317Abstract: The present invention provides combined property, dual-action compositions for application to a material, such as Gypsum Wall Board, ceiling tiles, joint compounds, concrete and other interior building materials, prior to an exposure of the material to fire, or prior to, during or after exposure of the material to conditions favorable to the growth of microbes. When compositions within the present invention are properly applied to a material prior to the material being exposed to fire, or prior to, during or after the material being exposed to conditions favorable to the growth of microbes, these compositions have the effect of reducing the amount of burning that occurs to the material, and/or reducing the amount or density of smoke and associated toxic gases produced by the material, when the material is exposed to fire.Type: ApplicationFiled: April 5, 2003Publication date: September 11, 2003Applicant: SMT, Inc.Inventors: Jon Lee Curzon, Thomas William Smoot
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Publication number: 20030147971Abstract: The invention is a dietary supplement for animals, especially dogs, for treating arthritis and joint discomfort. A biscuit form of the supplement may be in the form of a conventional carrier composition of, for example, typical dog biscuit materials including cereal grains, vegetables or animal meat, fat and by-products. Typically, the biscuit contains about 89-97 weight percent (wt. %) of the conventional carrier composition. Optional vitamins and minerals may also be added to the carrier material, typically in about the 1-5 wt. % range. Importantly, the biscuit of the present invention contains about 3-7 wt. % of an arthritis-treating combination, namely, glucosamine sulfate, vitamin C and an array of intracellular ions namely potassium, sodium and iodine. The glucosamine component is present by weight at approximately the same level as the vitamin C, and at approximately 10 (ten) times the level of the sum of the above-named intracellular ions.Type: ApplicationFiled: November 18, 2002Publication date: August 7, 2003Inventor: Andrew Myers
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Publication number: 20030133991Abstract: A synthesized composition containing zinc ions, calcium ions, rubidium ions and/or potassium ions in a pharmaceutically acceptable carrier, which, when applied to an open wound, effectively modulates the activity of at least MMP-2 and/or MMP-9 in the wound. A method for treatment of wounds is disclosed.Type: ApplicationFiled: November 27, 2002Publication date: July 17, 2003Applicant: Greystone Medical Group, Inc.Inventors: Stephen H. Monroe, Hans Hoekstra
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Patent number: 6593318Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.Type: GrantFiled: January 9, 2001Date of Patent: July 15, 2003Assignee: Pharmaceutical Resources Inc.Inventors: Narayan Ragunathan, James C. Chao, Robert A. Femia, Malcolm S. F. Ross
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Patent number: 6593320Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.Type: GrantFiled: April 30, 2002Date of Patent: July 15, 2003Assignee: Pharmaceutical Resources Inc.Inventors: Narayan Ragunathan, James C. Chao, Robert A. Femia, Malcolm S. F. Ross
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Publication number: 20030124202Abstract: Compositions and methods are provided for inhibiting skin irritations attributable to chemical irritants or environmental conditions by the application of anti-irritant amounts of aqueous-soluble divalent strontium cation.Type: ApplicationFiled: July 3, 2002Publication date: July 3, 2003Inventors: Gary S. Hahn, David O. Thueson
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Publication number: 20030124093Abstract: The present invention relates to a method for for treating, delaying and/or preventing renal dysfunction/failure in a mammal comprising administering a therapeutically effective amount of a substance capable of inducing and/or enhancing Pax2 expression. Furthermore, the invention relates to the use of an effective dose of a substance capable of inducing and/or enhancing Pax2 expression in a mammal for the preparation of a pharmaceutical composition for treating, preventing or delaying a renal dysfunction/failure in a mammal. Additionally, the present invention provides for a method for converting mesenchymal tissue into an epithelial tissue comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression in said mesenchym and for a method for the regeneration of renal stemcells comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression.Type: ApplicationFiled: September 27, 2002Publication date: July 3, 2003Inventors: Uwe Waldemar Rothenpieler, Michael Carl Elmar Imgrund
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Publication number: 20030118535Abstract: A depilatory composition and kit including the same are disclosed. The composition includes an emulsion having a viscosity of less than about 200 cps and an effective amount of a hair removing ingredient such as a thioglycolic acid. Methods of using the same are also disclosed and include spraying an effective amount of the emulsion on to a skin area containing unwanted hair, allowing the emulsion to remain in contact with the hair containing skin for a sufficient amount of time and thereafter wiping the skin to remove the remnants of the emulsion and hair.Type: ApplicationFiled: September 7, 2001Publication date: June 26, 2003Inventors: Adam Lustbader, Jose Torres
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Publication number: 20030104041Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.Type: ApplicationFiled: June 20, 2002Publication date: June 5, 2003Inventors: Tsung-Min Hsu, Nicole T. Gricenko, Alan T. J. Hickey, Eric C. Jacobson, Rose C. LoBello, Jane Obara, Eric C. Luo
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Methods and compositions for stimulating axon regeneration and preventing neuronal cell degeneration
Publication number: 20030103945Abstract: Agents which modulate a bcl family member to control axonal growth and regeneration are described. These bcl modulating agents promote axonal growth and regeneration in the neural cells of a subject. Compositions for promoting axonal cell growth in a subject also are described. The compositions of the present invention include an effective amount of an agent which modulates a bcl family member and in a pharmaceutically acceptable carrier. Other described aspects include packaged drugs for treating a state characterized by diminished potential for axonal growth. The packaged compounds and agents also include instructions for using the agent to promote axonal growth in a subject. An exemplary agent is lithium or a salt thereof.Type: ApplicationFiled: February 8, 2002Publication date: June 5, 2003Inventors: Dong Feng Chen, Xizhong Huang, Guang Chen, Husseini K. Manji -
Publication number: 20030099722Abstract: Methods and compositions for providing glutamine supplementation to a human by orally administering an effective amount of N-acetyl-L-glutamine or a nutritionally acceptable salt thereof. The N-acetyl L-glutamine or a nutritionally acceptable salt thereof can be incorporated into any liquid composition that is suitable for human consumption. Examples of suitable compositions include aqueous solutions such as for use as oral rehydration solutions and liquid nutritional formulas (including enteral formulas, oral formulas, formulas for adults, formulas for children and formulas for infants). The quantity of N-acetyl-L-glutamine or nutritionally acceptable salt thereof can vary widely but typically, these compositions will contain sufficient N-acetyl-L-glutamine or a nutritionally acceptable salt thereof to provide at least 140 mg of total glutamine per kg of body weight per day.Type: ApplicationFiled: October 9, 2001Publication date: May 29, 2003Inventor: Jeffrey H. Baxter
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Patent number: 6565891Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.Type: GrantFiled: August 23, 2002Date of Patent: May 20, 2003Assignee: Tsar Health Private Ltd.Inventor: Ranjit Kumar Chandra
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Patent number: 6562378Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.Type: GrantFiled: August 16, 2002Date of Patent: May 13, 2003Assignee: TSAR Health Private Ltd.Inventor: Renjit Kumar Chandra
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Patent number: 6555098Abstract: This invention provides deodorant and deodorant-antiperspirant cosmetic stick and roll-on products with an organic matrix having a dispersed phase of discrete particles of an encapsulated bicarbonate salt such as sodium bicarbonate, and discrete particles of an encapsulated fragrance compound such as musk ketone. The particle surfaces are coated with a polymer such as maltodextrin starch. When this type of cosmetic product is applied to underarm surfaces, the deodorizing activity is signaled by the release of a fragrance aroma.Type: GrantFiled: February 22, 1996Date of Patent: April 29, 2003Assignee: Church & Dwight Co., Inc.Inventors: Richard T. Murphy, Wolfgang R. Bergmann
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Publication number: 20030077301Abstract: Provided is a topical pharmaceutical composition for the treatment of inflammatory dermatoses, including acne vulgaris, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of inflammatory dermatoses plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.Type: ApplicationFiled: June 21, 2002Publication date: April 24, 2003Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
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Publication number: 20030077333Abstract: The present invention is directed to a zinc supplemented ORS and its use in the treatment of diarrhea.Type: ApplicationFiled: June 4, 2001Publication date: April 24, 2003Inventors: Kenneth M. Phillips, Amy L. Marchio, Paul F. Pollack
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Publication number: 20030073626Abstract: The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.Type: ApplicationFiled: March 5, 2002Publication date: April 17, 2003Inventors: David R. Hathaway, Thomas R. Coolidge
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Publication number: 20030072814Abstract: Provided is a topical pharmaceutical composition for the treatment of warts, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of warts plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. This composition can be used to treat human papilloma virus infections, particularly cutaneous warts.Type: ApplicationFiled: June 21, 2002Publication date: April 17, 2003Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
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Patent number: 6541038Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.Type: GrantFiled: May 25, 2000Date of Patent: April 1, 2003Assignee: SDS Biotech K.K.Inventors: Keijitsu Tanaka, Hirobumi Aoki, Takashi Echigo
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Patent number: 6541040Abstract: The invention relates to a mixture for use as wound dressing, which comprises: a) paraffins complying with DAB and/or synthetic waxes selected from the group consisting of montan waxes, petroleum waxes, Fischer-Tropsch waxes, polyolefin waxes, petrolatum, wax alcohols, and oxidates of the aforementioned substances; b) at least one metal hydroxide. The mixture is stable on prolonged storage at room temperature and promotes collagen regeneration in vivo in cases of bone trauma.Type: GrantFiled: October 9, 1998Date of Patent: April 1, 2003Assignee: Ernst Milbauer KGInventor: Wolfgang Mühlbauer
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Patent number: 6537589Abstract: An artificial bone promotive of osteoanagenesis comprising a calcium phosphate cement and a linear polyphosphate, wherein the calcium phosphate cement comprises &bgr;-tricalcium phosphate, monocalcium phosphate, calcium sulfate hemihydrate and other additives. The artificial bone is non-toxic to the body chemically stable, and has an excellent biodegradability. The artificial bone may be applied as substitutes for bone cements, allografts and autografts.Type: GrantFiled: July 25, 2000Date of Patent: March 25, 2003Assignee: Kyung Won Medical Co., Ltd.Inventors: Soo Kyung Chae, Hong Yeoul Kim, Ho Yeon Lee, Chang Hun Lee, Kang Moon Seo
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Publication number: 20030049331Abstract: The synergistic combination of a loop diuretic and lithium is useful in the treatment of DNA viral infections.Type: ApplicationFiled: September 3, 2002Publication date: March 13, 2003Inventor: Christopher Edward Hartley
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Publication number: 20030049272Abstract: A pharmaceutical composition which reduces or eliminates the drug abuse potential of central nervous system stimulant comprising: (a) a central nervous system stimulant selected from the group consisting of methylphenidate, amphetamine, methamphetamine, and combinations thereof; and (b) a mucous membrane irritant selected from the group consisting of organic and inorganic acid, salt, ketone, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate, titanate, amino acid, peptide, and combinations thereof, wherein the mucous membrane irritant produces irritation when contacted with the skin or mucous membrane.Type: ApplicationFiled: August 30, 2001Publication date: March 13, 2003Inventors: Yatindra Joshi, Russell Somma
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Patent number: 6521265Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.Type: GrantFiled: June 13, 2000Date of Patent: February 18, 2003Assignee: Biolife, L.L.C.Inventor: James A. Patterson
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Publication number: 20030027817Abstract: The invention provides methods and compositions for the treatment of Bipolar Disorder, Bipolar Depression or Unipolar Depression, all with or without psychotic features. This method employs a compound having activity as an atypical antipsychotic and a serotonin reuptake inhibitor.Type: ApplicationFiled: June 7, 2002Publication date: February 6, 2003Inventor: Gary Dennis Tollefson
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Publication number: 20030012827Abstract: The present invention is directed to a method of treating patients with major depression by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of a pharmaceutical composition, or as part of a larger molecule, e.g., a triacylglycerol, which releases free fatty acid after ingestion by a patient.Type: ApplicationFiled: February 27, 2002Publication date: January 16, 2003Inventor: Andrew Stoll
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Publication number: 20030003163Abstract: A method and composition for the restoration and maintenance of gingival and periodontal health are provided. The composition includes a potassium as an essential ingredient, which acts as an anti-bacterial agent. In some embodiments, the compositions include an osmotic agent other than potassium.Type: ApplicationFiled: May 13, 2002Publication date: January 2, 2003Inventor: Milton Hodosh
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Publication number: 20020192302Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of antidepressant drugs. The methods entail the use of a base in order to increase the flux of the drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.Type: ApplicationFiled: June 19, 2002Publication date: December 19, 2002Inventors: Tsung-Min Hsu, Alan T. J. Hickey, Eric C. Luo, Jane Obara
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Publication number: 20020192242Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of bone density regulators. The methods entail the use of a base in order to increase the flux of the bone density regulator through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.Type: ApplicationFiled: June 19, 2002Publication date: December 19, 2002Inventors: Tsung-Min Hsu, Rose C. LoBello, Eric C. Luo
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Publication number: 20020192300Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of antipsychotic agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.Type: ApplicationFiled: June 19, 2002Publication date: December 19, 2002Inventors: Eric C. Luo, Alan T. J. Hickey, Eric C. Jacobson, Tsung-Min Hsu
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Publication number: 20020192303Abstract: The present invention provides a composition and method for minimizing side effects associated with alcohol consumption. The composition includes an effective amount of a calcium antagonist, an osmo regulator which increases the alcohol clearance rate, and a fatty acid binder. Particularity a preferred embodiment comprises an effective amount of magnesium, and effective amount of taurine, and an effective amount of carnitine. The method of minimizing side effects associated with alcohol consumption includes administering an effective amount of the above enumerated composition to an individual in need of such an effect. The composition may be administered in various manners and times.Type: ApplicationFiled: June 1, 2001Publication date: December 19, 2002Inventors: Stefan Arver, Olof Haglund
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Publication number: 20020192301Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of antihypertensive agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.Type: ApplicationFiled: June 19, 2002Publication date: December 19, 2002Inventors: Eric C. Luo, Eric C. Jacobson, Tsung-Min Hsu
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Patent number: 6495169Abstract: Described is a process of producing a concentrated liquid biocide formulation. Mixed together are (a) bromine chloride or bromine and (b) an aqueous solution of alkali metal salt of sulfamic acid having a pH of at least about 7, in amounts such that (i) the active bromine content of the solution is at least about 100,000 ppm (wt/wt), and (ii) the atom ratio of nitrogen to active bromine from (a) and (b) is greater than 1 when bromine is used and is greater than 0.93 when bromine chloride is used. Use of bromine chloride as the source of the active bromine in the process is preferred because in the resulting aqueous compositions, all of the bromine of the bromine chloride is made available as active bromine in solution. In other words, the chlorine of the bromine chloride is converted in the process to dissolved alkali metal chloride salt, thereby liberating all of the bromine as the active bromine content of the biocidal composition.Type: GrantFiled: December 8, 1999Date of Patent: December 17, 2002Assignee: Albemarle CorporationInventors: Robert M. Moore, Jr., Christopher J. Nalepa
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Patent number: 6495168Abstract: This invention relates, generally, to nutritional supplements which contain bioactive glass. These supplements are useful in both veterinary and human contexts. The compositions of the subject invention can be used to achieve a number of advantageous results including: enhancing the growth rates of young animals, osteogenic stimulation, strengthening the skeletal structure, and treating osteoporosis.Type: GrantFiled: March 26, 2001Date of Patent: December 17, 2002Assignees: USTherapeutics, LLC, USBiomaterials CorporationInventors: Jon K. West, David Greenspan, James L. Meyers
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Publication number: 20020187960Abstract: Microbial growth in an aqueous cyclodextrin composition is inhibited by the addition of a small, polar base to the composition so as to provide a pH of 10-14 to the composition. The base includes sodium potassium, calcium, magnesium and ammonium hydroxides and carbonates as well as ethylamine, diethylamine and triethylamine. The composition is the resulting alkalaine, aqueous cyclodextrin solution. Adjusting the pH to the alkaline side shows superior antimicrobial action compared to conventional antimicrobial agents.Type: ApplicationFiled: April 26, 2001Publication date: December 12, 2002Inventors: Chris Sikorski, Roland Beck