Abstract: The present invention relates to the use of one or more free radical scavengers as prophylactically or therapeutically effective substances and microparticles having an average particle size ranging from 5 to 200 ?m for the preparation of a topical pharmaceutical composition for the protection or treatment of skin or hair damages caused by chemotherapeutic treatment. The invention also concerns a method for the protection or treatment of skin and hair damages of a mammal caused by chemotherapy. The invention further relates to a kit for the protection or treatment of hair damages caused by chemotherapeutic treatment consisting of a topical composition comprising microparticles together with free radical scavengers and a shampoo for an effective hair cleaning and supporting the hair treatment.

Abstract: The invention relates to a composition for pharmaceutical or dietary use that possesses antioxidant activity and characterized in that it contains as active principle a combination of catechin quercetin, which exert a synergistic action when combined in mutual molar ratios selected within a critical range, from 6:1 to 3:1 mol of catechin:quercetin.

Abstract: The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering to the cell at least one non polar grape seed extract, for example, a nonpolar grape seed extract obtained using hexane as an extraction solvent. The nonpolar grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.

Abstract: A new orally administerable DHEA production promoter is provided. A composition containing an extract of at least one selected from the group consisting of plants of Rosaceae Crataegus, Saururaceae Houttuynia, Vitaceae Vitis, and Compositae Anthemis is provided as a DHEA production promoter. The extract may be of one of the plants or extracts of two or more of them may be used in combination. A specific example is preferably a mixture of extracts of all four of the aforementioned plants. This DHEA production promoter also can be used as, for example, an anti-aging agent such as a skin improver as well as a pharmaceutical agent such as an immunostimulator, an antidiabetic agent, an anti-osteoporosis agent, an antiarteriosclerotic agent, an anti-obesity agent, a sleep-promoting agent, and a central nervous system depressant.

Abstract: The present invention provide a method for the prevention and treatment of a neurodegenerative disease including Alzheimer's Disease, Huntington's Disease, and Parkinson's Disease, using a grape seed extract or one or more compounds derived therefrom. In particular, the present invention provides a method to treat a patient diagnosed with, or at the risk of developing, a neurodegenerative disease by administering a pharmaceutical composition comprising a grape seed extract or one or more compounds derived therefrom to the patient in a therapeutic amount to reduce the accumulation, aggregation or deposition of amyloid beta or its oligomers, and/or to reduce the misfolding, accumulation and/or aggregation of tau proteins or other proteins.

Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

Abstract: Dietary supplement compositions include an adaptogenic agent, an anti-inflammation agent, and an anti-oxidant. Methods for using dietary supplement compositions include (i) inhibiting, decreasing, and/or preventing delayed onset of muscle soreness (DOMS); (ii) inhibiting, decreasing, and/or preventing exercise-induced muscle damage; and/or (iii) modulating the expression of genes that are correlated with exercise-induced muscle damage.

Abstract: Methods for treating amyloid disease in a patient wherein the method comprises administration of a therapeutically effective amount of a composition comprising Uncaria tomentosa extract and Grape Seed Extract.

Abstract: A dietary supplement composition having an ORAC value in excess of at least about 2,500 and which can be readily consumed in a small quantity is provided for supplementing an individual's daily intake. The dietary supplement composition suitably includes organic and/or vegan ingredients and can be consumed in quantities of as little as about 1 tablespoon to provide an amount of antioxidants equivalent to at least the minimum recommended daily intake of five to nine servings of fruits and/or vegetables.

Abstract: An herbal composition for providing a beneficial effect to the respiratory tract. The composition includes Colt's Foot, Mangosteen, Thyme Leaf, Wild Cherry Bark, Quercitin, Sundew, Butterbur, and Grape Seed Extract. In particular, the composition may prevent or treat cough. Also described are methods of using the herbal composition.

Abstract: Compositions for the treatment of the affections of the oral cavity and upper respiratory tract include anthocyanosides, procyanidins and phloroglucinols. The anthocyanosides are derived from Vaccinium myrtillus extract, the procyanidins are derived from a Vitus vinifera extract, a Camellia sinensis extract or from other edible plants containing procyanidins, and the phloroglucinols are derived from Hypericum spp., Myrtus spp. or Humulus lupulus extracts.

Abstract: Shampoos providing hair treated therewith improved strength, handle and tensile strength, as well as combability in the dry and wet states and, at the same time, are particularly mild and ecologically compatible, and contain, in a cosmetically acceptable carrier, 0.1 to 35% by weight of at least one surfactant and 15 to 85% by weight of at least one fruit juice or vegetable juice.

Abstract: This document provides dietary supplements. For example, compositions having a combination of ingredients useful in providing a broad scope of antioxidant protection for human or animal consumption are provided.

Abstract: The present invention relates to therapeutic compositions and methods of treatment that contain or employ at least two of: an oligomeric proanthocyanidin; a protease inhibitor; and/or a lactoferrin. The compositions of this invention may be in various forms depending upon the disease or condition to be treated. The compositions and methods of this invention are useful to treat a patient suffering from or susceptible to gram negative bacterial infections, including those associated with cystic fibrosis, ear infections and with wounds.

Abstract: Methods for stabilizing, maintaining the activity of and inhibiting growth of microorganisms in sunscreen preparations, anti-oxidant preparations and topical and oral pills and supplements by addition of at least one molecule chosen from nitroxides and nitrones and compositions produced thereby are provided.

Abstract: The invention relates to a novel solubilized benzoyl peroxide topical formulation for the treatment of acne comprising: benzoyl peroxide, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the benzoyl peroxide is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.

Abstract: The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering at least one grape seed extract to the cell. The grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.

Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.

Abstract: Compositions and methods relating to partially hydrolyzed fucoidan for use in dietary supplements are described. Fucoidan from brown seaweeds is partially hydrolyzed and then mixed with other ingredients for use as a dietary supplement in beverage, capsule, or tablet form. The fucoidan is partially hydrolyzed with acid and heat. The partially hydrolyzed fucoidan can also be sulfonated. Other ingredients that can be included in the dietary supplement include high-ORAC-value antioxidants, minerals, pepper extract, flavoring agents, coloring agents, and preservatives. The compositions can be in the form of beverages, tablets, capsules, powders, and the like.

Abstract: A composition for treating damaged tissue and promoting healthy tissue growth, healing and tissue regeneration, wherein said composition comprises an extracellular matrix compound, a surface-active lipid, one or more enantioinerically pure L-amino acids or glycine, a hydrophilic surfactant with a high HLB, as well as vitamins, minerals or trace elements. Not only does it maintain good health, but the components are non-intrusive, bio-safe, non-coalescent and can mimic normally occurring stem-cells within a body. When applied to diseased tissues, the subject compositions can stimulate, facilitate, and accelerate protein synthesis for the regeneration of diseased organs and tissues. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.

Abstract: The present invention relates to plant sprout-based stable oil-in-water emulsions wherein the monacyl- and diacylglycerol content is at least 20% by weight, the free fatty acid content is not more than 10% by weight and comprise an aqueous homogenate of sprouted oily seeds of which the own enzymes and emulsifying substances are capable to form the emulsion. Furthermore, the invention also relates to the preparation of said emulsions as well as to various applications thereof.

Abstract: In recent years the demand for cosmetic compositions and cosmetic methods for improving the appearance and condition of skin has grown enormously; consumers are seeking topical skin care products that help treat or delay the signs of natural (chronoaging) and environmental aging. The present invention relates to topical compositions for application to human skin and to their use in improving the condition and appearance of skin. It is based on the premise that effective treatment of normal skin conditions due to natural or environmental aging, such as wrinkles, lines, sagging, hyperpigmentation and age spots, and/or of sensitive, dry, rough, flaky, red, itchy, irritated skin may be obtained through the application of cosmetic compositions to the skin which comprise a combination of collagen stimulators, phytoestrogens, plant derived anti-inflammatory agents, fatty acid, antioxidants.

Abstract: The invention relates to a cosmetic composition containing lingonberry extract and its use on skin cosmetology thereof. The present invention has provided a lingonberry extract wherein containing polyphenols components including anthocyanidin, procyanidin, resveratrol, catechin and so on. The present invention also relates to the application of lingonberry extract on skin cosmetology, including without limitation whitening, diminishing visible pigmentation, anti-wrinkle, moisturizing, smoothing and improving skin sensitivity. The invention also has revealed drugs, cosmetic composition and food prepared by using lingonberry extract. Comparing with the prior art cosmetic compositions, the said lingonberry extract of the present invention has higher effects and safe.

Abstract: To provide a method for the manufacture of polyphenols that enables industrial manufacture of polyphenols containing water-soluble proanthocyanidins from grape seeds. The seeds of grape berries dried after squeezing out the juice are separated into grape seeds and peel with a separation apparatus, and the grape seeds are stirred in a washing machine to remove contamination thoroughly. The grape seeds are charged into a boiling kettle and heated for the prescribed time at the prescribed temperature. Then, germination is induced in a curing kettle maintained at the prescribed temperature preferred for the germination. The grape seeds in which germination or germination and differentiation have advanced are crushed, mixed with water to obtain an emulsified state, and a salt is added, if desired.

Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

Abstract: The present invention provides a composition comprising (a) an antimicrobial compound of the formula (I) wherein R1 is a fatty acid chain; R2 is a linear or branched alkyl residue having from 1 to 12 carbon atoms; n is an integer from 0 to 10; X? is selected from Br?, I?, Cl? and HSO4; (b) an antimicrobial material selected from lanthionine bacteriocins, tea [Camellia sinensis] extract, hop [Humulus lupulus L.] extract, grape skin extract, grape seed extract, Uva Ursi extract and combinations thereof.

Abstract: The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.

Abstract: A foodstuff, includes: an extract of a plant of genus Salacia; and a flavonoid, wherein 50% inhibition concentration (IC50 value) of sucrase is 300 ?g/ml or less.

Abstract: Disclosed is a dry composition prepared from red grape by natural fermentation that is, once brewed, steeped within hot water, tasteful to ingest as herb tea, and that complementary contains antioxidants, Catechin, Resveratrol, Tannin, Quercetin bearing anti-inflammatory and blood glucose lowering capacities; as well as a human skin rejuvenating natural product derived there from.

Abstract: The present invention provides an in vitro resveratrol-rich callus tissue of Vitis thunbergii Sieb. et Zucc. which is a callus tissue developed from a tissue culture system containing one or more plant growth regulators (PGRs) and cultured from a stem or a petiole tissue explant of a wild type of V. thunbergii or a cultivated plantlet of V. thunbergii. The cultivated plantlet is in turn derived from a shoot of the wild type of V. thunbergii cultivated in a plantlet culture system containing no PGRs. The in vitro resveratrol-rich callus tissue of V. thunbergii is characterized by its containing at least about 1,000 to 10,000 mg/kg of dried weight of resveratrol, predominantly in the form of trans-resveratrol and/or resveratrol-O-glucoside, and being ready for harvest or subculture in about 30 days.

Abstract: Systems and methods are provided herein that provide for promoting cellular health and treatment of cancer, and allied diseases such as diabetes and glaucoma.

Abstract: Compositions including synergistic combinations of ascorbic acid, Indian gooseberry, and additional components for increasing the antioxidant capability of certain target components, such as superfruits, fruits, and other low and/or high antioxidant containing substances. Particular combinations of ascorbic acid, Indian gooseberry extract, one or more citrus bioflavanoids, and one or more fatty acids added to various target components synergistically increases the antioxidant capability of the overall composition over expected values.

Abstract: A feed supplement for dairy cows and goats containing various combinations of whole soy, muscadine grapes, Kudzu leaves, brassica group vegetable and or their chemical constituents designed to shift estrogen metabolism towards favorable estrogen chemistry.

Abstract: The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also discloses devices for delivering this composition to target tissues.

Abstract: The present invention relates to a novel grape extract, and processes for making such, that is useful for, inter alia, treating pre-hypertension, Metabolic Syndrome and/or the conditions that comprise Metabolic Syndrome. The processes of the present invention produce a highly concentrated polyphenol product by maximizing extraction of monomeric and oligomeric procyanidins and minimizing extraction of polymeric procyanidins. The grape extract of the present invention comprises between about 5-15% monomers, about 5-20% dimers, about 3-10% trimers, about 2-10% tetramers, and about 2-10% pentamers by weight. The grape extract of the present invention can be formulated into dietary supplements, including capsules, tablets, powders, solutions, gels, suspensions, creams, gels, and the like. These dietary supplements in, for instance, powder or solution form, may be added to nutraceuticals, foods and/or beverages to form functional nutraceutical, food, and/or beverage products.

Abstract: A topical skin care product is provided that contains therapeutic concentrations of turmeric and other constituents which is colorless upon application to the skin. The product can be used for cosmetic, protective, and healing purposes without staining skin or clothing yellow.

Abstract: Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.

Abstract: The present invention provides an extract of Taiwanese wild grape (Vitis thunbergii var. taiwaniana), which is prepared by extracting one or more tissues of Vitis thunbergii var. taiwaniana with 10 wt % to 100 wt % alcohol solution or water to obtain an extract solution, and then drying said extract solution. The extract of Vitis thunbergii var. taiwaniana of the present invention has the function of regulating blood pressure, and therefore can be used to prevent and treat hypertension. The present invention also provides a method for purifying (+)-vitisin A and ampelopsin C from Vitis thunbergii var. taiwaniana and a use of these two compounds for hypertension prevention and treatment.

Abstract: A dietary supplement composition comprising a therapeutically effective amount of at least one sirt 1 activating agent, a therapeutically effective amount of at least one Qi activating agent, and an therapeutically effective amount of at least one adaptogen is disclosed. An optional herbal treatment for stress-related deep wrinkles comprises chronic oral administration for at least two weeks of a beverage containing an effective amount of a valerian root extract sufficient to provide a desired reduction in the appearance of the deep wrinkles. A photoprotective agent may also be included. Also included are a microcirculation increasing agent. Also optional are an herbal toner and topical cellulite product.

Abstract: The present disclosure relates to antioxidant-stabilized composition containing at least one omega 3 polyunsaturated fatty acid (PUFA). The omega 3 PUFA may include eicosapentanoic acid, docosahexaneoic acid and combinations thereof. The compositions additionally contain an antioxidant package made from a mixture of: at least one form of vitamin E; ascorbyl palmitate; rosemary extract; and grape seed oil. The present disclosure further relates to a method of increasing the oxidative stability of concentrated fish oil.

Abstract: The present invention provides an improved process for preparing a Vitis vinifera pip extract. And also, the present invention provides a pharmaceutical composition for preventing or treating rheumatoid arthritis including the Vitis vinifera pip extract as an active ingredient.

Abstract: The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products.

Abstract: A carbohydrate modifying formulation that modulates the rate of sugar absorption and/or metabolism in a subject to whom the formulation is administered. In one embodiment, the formulation comprises an active soluble fiber, one or more polyphenolic compounds, an aqueous diluent, and sugar. In another embodiment, the formulation is a dry powder that comprises an active soluble fiber, antioxidant containing botanical extracts, crystalline fructose, a probiotic, vitamins and minerals.

Abstract: This invention describes a comprehensive nutraceutical designed to antagonize major mitigating factors to the degenerative process associated with Parkinson's disease. The formulation is comprised of a primary base of pyruvate, succinate, ?-Ketoglutarate and/or oxaloacetate, niacin/NADH, fruit extracts, anthocyanins, further combined with specific macro/micronutrients, trace elements, amino acids, flavonoids and concentrated plant sources. The nutraceutical contains all natural substances that should mitigate many of the neurodegenerative processes known to be associated with PD. Mechanisms addressed are to prevent the loss of ATP/by 1-methyl-4-phenylpyridinium rotenone, scavenge hydrogen peroxide/O2.

Abstract: Disclosed is a method of increasing firmness or elasticity or reducing the appearance of sagginess in the periorbital area of a person's skin, comprising topically applying to the skin in need thereof a composition comprising magnolia extract and vitis vinifera extract.

Abstract: The invention relates to the use of an aqueous grape seed extract combined with at least one fluorine salt for the preparation of an oral hygiene composition intended to prevent and/or reduce the formation and accumulation of dental biofilm on dental surfaces or on gingival epithelial tissue.

Abstract: Compositions and related methods directed at supporting weight loss. Compositions combining at least one appetite suppressing ingredient with at least one other ingredient for maintaining or reducing body weight are provided. Additional embodiments provide for more than one ingredient with appetite suppressing activity combined with at least one other ingredient for maintaining or reducing body weight.

Abstract: The invention relates to a protecting and regenerating composition. This composition comprises an association of a first cosmetically active ingredient comprising a dried vine shoot extract, and a second cosmetically active ingredient comprising a component of the ectoine type. This composition makes it possible to affect anti-ageing cosmetic care and skin revitalization.

Abstract: The present disclosure relates to methods and drug delivery systems for treating diseases involving inflammation, including Attention Deficit Hyperactivity Disorder (ADHD) by administering a CNS stimulant to a patient in need thereof so as to maintain steady state serum drug levels that remain therapeutically effective for about 24 and ½ to about 25-27 hours or longer after administration to maintain a constant steady state between doses of medication. The method is employed to restore normal catecholamine levels throughout the day without over-stimulating or under-stimulating the patient. Additionally, the present method of treating inflam?na?ion3 including ADHD, provides, for example, dosing once a day or once a week. The present method also addresses other aspects of the disease, for example, defective P-5-P synthesis, ehminating interleukins and free radicals, and correction of Amino acids, the endocrine system and inflammation.

Abstract: An herbal composition for providing a beneficial effect to the respiratory tract. The composition includes Colt's Foot, Mangosteen, Thyme Leaf, Wild Cherry Bark, Quercitin, Sundew, Butterbur, and Grape Seed Extract. In particular, the composition may prevent or treat cough. Also described are methods of using the herbal composition.