Abstract: Compositions and methods for administering one or more antioxidants to a human subject have been developed. The antioxidant-containing lipid vesicles of the invention provide a delivery system for antioxidants which can be applied topically to the skin.

Abstract: A topical composition for treating skin diseases is provided. The composition comprises calendula, tea tree oil, eucalyptus oil, grape seed oil, and Aloe vera. In some embodiment, the composition may also include beeswax, vegetable oil, vitamin E, rosemary oil, or shea butter or combinations thereof to further enhance its beneficial effects. In some embodiments, the composition may also include herbs. Kits and methods for treatment of skin diseases are also disclosed.

Abstract: A basic facial and body treatment cosmetic formulation is a combination of a cationic emulsifying agent, an oil soluble liquid polymer and a naturally occurring lactate buffer system. The basic formulation is a starter system that can be specialized to skin moisturizers, skin lighteners, skin pigmenting agents, sunscreens, antioxidants, line reducing products, wrinkle reducing products, anti-cellulite products, pharmaceuticals and the like.

Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Abstract: A mixture composition useful in wound healing comprising solvent extraction of anthrocyanin/proanthrocyanidin sources, ascorbic acid source, tannin or gallic acid source or polymeric gallic acid source, microbe source, protein source, fat source, acidification agent or buffer and sulfur absorbing compound.

Abstract: A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

Abstract: The present invention relates to compositions comprising vitamins, minerals and other nutrients and methods for using these compositions for nutritional supplementation to prevent and/or alleviate a patient from the occurrence or negative effects of cardiovascular disease. Specifically, the invention relates to compositions and methods of administering compositions comprising natural CoQ10, natural Omega-3 fatty acids, natural bioflavonoids, natural vitamin E, amino acids and derivatives thereof, minerals, extra virgin olive oil, lecithin, B-complex vitamins, and antioxidants.

Abstract: Compositions including a topical steroid, a blend of concentrated botanic seed oils, and a suitable vehicle for topical application to the skin are described. Compositions of the present invention can be used as a therapeutic method for treating skin conditions, including scalp conditions such as dandruff. The compositions are topically administered to the affected area of the skin of a mammal in need of such therapy. The botanic seed oils used in the compositions may be prepared using a cold press method, and may include three or more botanic seed oils. The blend of botanic seed oils may include, for example, red raspberry seed oil, black raspberry seed oil, pomegranate seed oil, blueberry seed oil, pumpkin seed oil, carrot seed oil, blackberry seed oil, grape seed oil, cranberry seed oil, and black cumin seed oil.

Abstract: The disclosure herein is directed to organic skin-based products that comprise an excess of 70% organic ingredients. The skin care products described herein are composed of a plurality of organic juices and other organic materials.

Abstract: A pharmaceutical topical spray composition including a topical corticosteroid, an alcohol, a propellant, isopropyl myristate, and a blend of botanic seed oils is described. The blend of botanic seed oils may include three or more botanic seed oils prepared using a cold press method. A method for treating an inflammatory skin condition by administering the pharmaceutical topical spray composition to the skin of a mammal is also described. The pharmaceutical composition is effective in the treatment of inflammatory skin conditions without the need for zinc pyrithione, undecylenic acid, or a detergent.

Abstract: The present invention provides a method for improving cognitive performance that encompasses all of: sense; perception; recognition; judgment; and action or suppression; and is based on a higher brain function. The method for improving cognitive performance of the present invention includes administering astaxanthin and/or an ester thereof to an individual. The cognitive performance is, for example, at least one selected from the group consisting of judging ability, spatial attention-allocating ability, concentration on the recognition of surroundings, and agility as determined by speed and/or accuracy of a body reaction which requires a higher brain function.

Abstract: The present invention relates to a fibroblast activator comprising grape sap as an active ingredient, a method of activating a fibroblast, using grape sap, and a method of using grape sap as a fibroblast activator. The present invention further relates to a collagen synthesis promoter comprising grape sap as an active ingredient, a method of promoting collagen synthesis using grape sap, and a method of using grape sap as a collagen synthesis promoter. The present invention further relates to a skin antiaging agent comprising grape sap as an active ingredient, a method of preventing aging of skin using grape sap, and a method of using grape sap as a skin antiaging agent. The present invention provides highly safe and effective means of preventing aging.

Abstract: A prevention and therapy pharmacy composition for allergic rhinitis, atopic dermatitis and asthma includes at least one crude drug extract selected from the group including wormwood, guava leaves, mulberry tree leaves and grape seeds as an effective component. The functional composition may be used for manufacturing a medicine composition and health function food with its anti-allergic rhinitis, anti-atopic dermatitis and anti-asthma activity effects.

Abstract: In one embodiment, a composition containing an effective amount of Cissus quadrangularis and one or more plants selected from the Brillantaisia and Vernonia plant families whereby the composition reduces the amount of fat absorbed or reduces weight in a mammal. Such compositions have beneficial activity principally in controlling weight gain and obesity, especially in conjunction with chitosan or a chitosan derivative and an antioxidant such as vitamin C.

Abstract: Disclosed are methods of controlling body weight in estrogen-insufficient women by administering compositions comprising (A) those dried fruit solids that inherently comprise flavonoids, hydroxycinnamic acids, and a fiber component of which at least about 20% by weight is soluble fiber, and (B) a soluble, indigestible oligosaccharide in addition to any soluble fiber inherently in the dried fruit solids. The dried fruit solids may also be characterized as those selected from dried plum, dried grape, dried date, or dried fig. Administration of dried fruit solids (e.g., dried plum solids) in combination with soluble indigestible oligosaccharides (e.g., fructooligosaccharides) are surprisingly effective in controlling body weight gain in estrogen-insufficient women.

Abstract: This present invention discloses disease-associated molecules and assays, which are useful for diagnosing the presence or risk of developing osteoarthritis (OA) or related conditions. The invention has practical use in the early diagnosis of disease, in monitoring mammals at risk of developing OA, and in enabling better treatment and management decisions to be made in clinically and sub-clinically affected animals.

Abstract: The present invention relates to a use of grape seed extract or its constituents to treat conditions which benefit from an inhibition of cytochrome P450 2A6 (CYP2A6). In particular conditions which benefit from the inhibition of CYP2A6 are conditions which benefit from decreased metabolism of nicotine to cotinine, for example, preventing, reducing or treating smoking, and conditions which benefit from a decrease in the in vivo formation of carcinogens, for example prevention or treatment of cancer.

Abstract: This invention relates to the use of a vinic alcohol in cosmetic compositions, perfumes and personal care products. The vinic alcohol is characterized as being a product from the grape fermentation followed by purification by distillation, and is used in this invention in total or partial substitution of the conventional ethylic alcohol. The vinic alcohol contains residual substances, which are a characteristic feature of the fermentation of grapes, affording a characteristic odor to the ethanol, contributing to a different olfactory sensorial perception.

Abstract: A process for the extraction of Vitis vinifera seeds which comprises: a) extraction of grape seeds with a solvent (total extract); b) removal of water-insoluble tannins; c) optional removal of water-soluble tannins; d separation of the products with different MW, through chromatographic purification on a column.

Abstract: An extract of the grape plant obtained from grape plant cane is a powerful anti-oxidant, and offers a unique combination of beneficial organic chemicals, including trans-resveratrol, trans-viniferin, and oligostiibines. The grape plant cane product is produced essentially exclusively from grape plant cane, which is often discarded by vintners. Methods of making this product include solvent extraction from the grape plant cane, followed by vacuum drying without overheating the product. The grape plant cane extract may be used as an anti-fungal, antibiotic, antiseptic, preservative, as a topical application to improve moisture retention of human skin, and to extend the shipping and shelf life of produce, among other uses. A method for using the grape plant cane extract as a food supplement involves daily human ingestion of desired amounts of a food-grade grape plant cane product.

Abstract: The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products.

Abstract: The present invention relates to a composition for prophylaxis or treatment of urinary system infection, comprising a matrix metalloproteinase inhibitor. The present invention also relates to a method for prophylaxis or treatment of urinary system infection, comprising administering to a patient in need of such treatment an effective amount of composition comprising a matrix metalloproteinase inhibitor.

Abstract: To provide an endurance improver, anti-fatigue agent and anti-aging agent having an ingredient taken for long years as a food, having high safety, easily available, and excellent in processability. An endurance improver, anti-fatigue agent, muscle strength improver, motor performance enhancer and anti-aging agent containing resveratrol and/or grape leaf extract as an effective ingredient.

Abstract: The invention provides a novel herbal soft drink comprising decoction of plants selected from Sida sps., Vitis vinifera, Withania somnifera, Boerhaavia diffusa and Tinospora cordifolia for the protection and prevention of health and in particular, but not exclusively with antioxidant, immunoenhancing, hepatoprotective, cardiotonic, diuretic, digestive, choleretic, nervine relaxant properties.

Abstract: A method for increasing the longevity of an old animal comprising administering to the animal a composition comprising one or more antioxidants in a total antioxidant amount sufficient to increase the longevity of the animal.

Abstract: In certain embodiments, the invention comprises the use of plant-derived substances to reduce body fat and/or to increase insulin sensitivity in mammals. In certain embodiments, the invention comprises a composition for reducing the amount of fat in the body of a mammal, the composition comprising at least one plant-derived substance which inhibits adipogenesis in the body of the mammal and at least one plant-derived substance which promotes lipolysis in the body of the mammal. In certain embodiments, the invention comprises a composition for reducing the amount of fat in the body of a mammal, the composition comprising at least one plant-derived substance which inhibits adipogenesis in the body of the mammal, at least one plant-derived substance which promotes lipolysis in the body of the mammal, and at least one plant-derived substance which inhibits lipogenesis in the body of the mammal.

Abstract: Two-phase preparation for temporally gradual administration comprising a) a phase (A) comprising water soluble vitamins and/or the corresponding provitamins, wherein phase (A) does not contain liposoluble vitamins or provitamins corresponding to liposoluble vitamins, b) a phase (B) comprising vitamins and/or the corresponding provitamins, wherein the quantity of liposoluble vitamin compounds is larger than the quantity of water soluble vitamin compounds.

Abstract: Methods for treating amyloid disease in a patient wherein the method comprises administration of a therapeutically effective amount of a composition comprising Uncaria tomentosa extract, Gingko Biloba, Green Tea Extract, Grape Seed Extract and/or Curcumin.

Abstract: The invention relates to the development of compositions and methods for increasing the amount of collagen cross-linking in a mammalian tissue. A typical composition as described herein includes at least one cross-linking agent such as a bioflavonoid compound (e.g., proanthocyanidin), a grape seed extract, a Casein Phosphopeptide-amorphous Calcium Phosphate, or an iridoid compound (e.g., genipin) in an amount effective for increasing collagen cross-linking in the mammalian tissue in a pharmaceutically acceptable carrier. A typical method for increasing the amount of collagen cross-linking in dentin in a mammalian tooth includes the steps of preparing the surface of the tooth to be treated; and applying a composition including at least one of: a bioflavonoid compound, a grape seed extract, a Casein Phosphopeptide-amorphous Calcium Phosphate, and an iridoid compound in a pharmaceutically acceptable carrier to the tooth surface for a time period of 0.0001 hours to about 4 hours.

Abstract: The present invention provides a skin care product comprising at least two enhancers and at least one skin care ingredient, wherein the at least two enhancers are selected from cyclodextrin, pentasodium pentetate, phytic acid, potassium citrate, sodium citrate, potassium gluconate and sodium gluconate.

Abstract: The invention relates to medicine, in particular to pharmacology, and is embodied in the form of an agent for limiting neuro-mediator, neuro-endocrine and metabolic disturbances generating the disorders of a central nervous system and functional somatic disorders. The inventive agent is based on a DSIP (delta sleep inducing peptide) or a derivative chemically related thereto and can be used for correcting and preventing functional shifts in a central nervous system and concomitant somatic disorders caused by unfavourable and extreme environmental factors and different pathological conditions of an organism or during the ageing thereof.

Abstract: A kind of health supplement for lowering plasma glucose and plasma triglyceride is prepared from a mixture of dried grape skins with the flesh removed, dried grape seeds and dried grape stems, and the mixture is ground into fine powder (termed 3SG powder) according to a ratio of volume between the grape skins, the grape seeds and the grape stems found in naturally available grapes; upon treatment of the 3SG powder with ethanol, the intracellular lipid-soluble flavonoids of the 3SG powder are released to give rise to the health supplement which functions include to lower plasma glucose and plasma triglyceride, as well as to attenuate anomalous energy metabolism in diabetic, hyperglycemic, and hyperlipidemic people.

Abstract: The disclosure provides oral compositions having at least two botanical active ingredients derived from plants. The oral composition also includes an orally acceptable vehicle to deliver an effective amount of the at least two active ingredients in vivo. The botanical active ingredients provide particularly efficacious antimicrobial (antibacterial, antiviral, and/or antifungal), antioxidant, anti-inflammatory, anti-ageing, and or healing properties to the oral compositions.

Abstract: An oral supplement or topical supplement containing glucosamine sulfate and oleocanthal provides relief of pain and reduces inflammation in joints. The topical supplement is used in conjunction with a heat patch.

Abstract: The invention relates to revitalizing layers of the skin which have been damaged by sunlight exposure and particularly ultraviolet radiation by applying a topical solution composition that includes a concentrated amount of resveratrol which has been extracted from a red wine.

Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded, and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.

Abstract: A method and composition for the treatment of diabetic neuropathy is disclosed. A preferred embodiment of the invention relates to a topical composition for the treatment of systems related to diabetic neuropathy by application to the affected area. The composition provides relief of these symptoms and inhibits those factors that contribute to these systems, such as an aldose reductase inhibitor A preferred embodiment of the invention relates to a method of treatment for diabetic neuropathy utilizing a regime of administrations of a topical composition in amounts effective to counter those areas of the body affected by peripheral neuropathy. Yet another preferred embodiment of the invention relates to a method of improvement of those areas effected by diabetic peripheral neuropathy using a topical composition over an effective period of time.

Abstract: Compositions and related methods of Cissus quadrangularis plant extracts and soy albumin that improve various cardiovascular risk factors and metabolic risk factors that cause Syndrome X. In one exemplary embodiment, university studies demonstrated that a formulation of 300 mg Cissus quadrangularis plant extract, 3 mg niacin-bound chromium, 500 mg of green tea extract, 24 mg of selenium, 100 mg of soy albumin, 100 mg of vitamin B6, 0.1 mg of vitamin B12 and 0.8 mg of folic acid to obese and overweight humans daily for eight weeks provided unexpected synergistic results that improved a variety of health related factors.

Abstract: The present invention relates mainly to a cosmetic process for making up and/or caring for keratin material(s), comprising the application, on contact with a keratin material, of at least one cosmetic composition comprising at least 75% by weight, relative to its total weight, of compound(s) approved for food use and having a gloss value at least greater than or equal to about 5.

Abstract: A dietary supplement composition comprising a therapeutically effective amount of at least one sirt 1 activating agent, a therapeutically effective amount of at least one Qi activating agent, and a therapeutically effective amount of at least one adaptogen is disclosed. An optional herbal treatment for stress-related deep wrinkles comprises chronic oral administration for at least two weeks of a beverage containing an effective amount of a valerian root extract sufficient to provide a desired reduction in the appearance of the deep wrinkles. A photoprotective agent may also be included. Also included are a microcirculation increasing agent. Also optional are an herbal toner and topical cellulite product.

Abstract: A spray delivery system in combination with a scalp medication is provided which includes a portable container having a gas imperious container wall, a pressure source disposed within the container, and a selectively operable valve assembly affixed to the container. The scalp medication is in liquid form and is disposed within the container. The scalp medication comprises a hair growth stimulation or hair growth maintenance active ingredient in an amount sufficient to stimulate or maintain hair growth disposed within a pharmacologically acceptable carrier solution. The valve assembly of the system produces a 1 mL spray of said scalp medication within about 5 seconds following a single operation of said valve assembly. A method of treating alopecia using a continuous spray employing such a system is also provided. Both bag-on-valve (bag-in-can) and metered dose packages are disclosed.

Abstract: The invention relates to the administration of products enhanced with Morinda citrifolia L. in order to inhibit anaerobes, gram negative bacteria, protozoa and other microbial growth related to various maladies and illnesses which result in detrimental physiological effects.

Abstract: A method to enhance disease resistance in an animal comprising feeding the animal a diet enriched in antioxidants and providing behavioral enrichment. In one embodiment, the behavioral enrichment comprises exercising the animal regularly effective to cause behavioral enrichment, wherein the feeding and exercising combination is effective to increase neutrophil phagocytosis and B cell percentages.

Abstract: Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application.

Abstract: Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application.

Abstract: The invention relates to a composition for use in the prevention and treatment of cancer. The composition includes fermented soy extract, oligomeric proanthocyanidin, epigallocatiechin gallate, spirulina, curcumin and Antrodia camphorata. The composition of the invention effectively prevents the growth of cancer cells, especially colorectal cancer, ovarian cancer, breast cancer, cervical cancer, and liver cancer.

Abstract: The present invention is directed towards an orally administered composition comprising multiple plant extracts, which are characterized as having high ORAC values, and promote an increase in a mammal's dietary intake of antioxidant and polyphenols to a therapeutically effective amount. The ingredients of the present compositions represent a broad spectrum of polyphenols providing antioxidant activity for the purpose of improving general health and vitality by enhancing cardioprotection and immune system functions. The composition of the present invention comprises an extract of Polygonum cuspidatum and an extract of grape skin. In additional aspects of the present invention, one or more of Red wine extract, piceantannol, krill oil, pomegranate, mangosteen, apple, goji (wolfberry), and acai berry, cranberry, mulberry, bilberry, noni, and blueberry are added to the composition to further broaden the polyphenol spectrum. Both a composition and method are provided by the present invention.

Abstract: Dietary supplement formulations are described that provide benefits of soluble fiber accompanied by excellent taste with many different health benefit combinations.

Abstract: Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

Abstract: The invention pertains to a water dispersible, preferably a powder composition of water extractible bioactive components of exclusively fruit or vegetable or plant origin. These components are obtainable by: a) subjecting a selected fruit or vegetable or plant material to homogenisation in weak alkaline conditions and at moderate temperature; b) separating the liquid extract from the homogenised mass and subsequently bringing it to neutrality; and c) eventually concentrating or drying, preferably by freeze drying, the neutralized liquid extract. The composition can be used as primary composition in the preparation of a food product for oral administration, a food supplement, a pet food product, a pet food supplement, a cosmetic preparation or a pharmaceutical preparation.