Particle Containing A Transition, Actinide, Or Lanthanide Metal (e.g., Hollow Or Solid Particle, Granule, Etc.) Patents (Class 424/9.32)
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Patent number: 8617522Abstract: Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.Type: GrantFiled: December 28, 2012Date of Patent: December 31, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Parvesh Sharma, Brij M. Moudgil, Glenn A. Walter, Stephen R. Grobmyer, Swadeshmukul Santra, Huabei Jiang, Scott Chang Brown, Edward W. Scott, Qizhi Zhang, Niclas Bengtsson
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Publication number: 20130330279Abstract: The present disclosure provides compositions and methods of treating Breast Cancer. Disclosed is a nanoparticle paired to at least one of W genetic materials that suppress key regulators of fat synthesis (e.g. Rev-erb) to cause a predefined target cell types apoptosis or X predefined targeting moieties that cause predefined target cell types apoptosis and correspond to Y predefined target parameters associated with Z predefined target cell types in connection with treatment of at least one of the following breast cancer, glioblastoma, head and neck cancer, pancreatic cancer, lung cancer, cancer of the nervous system, gastrointestinal cancer, prostate cancer, ovarian cancer, kidney cancer, retina, cancer, skin cancer, liver cancer, genital.Type: ApplicationFiled: December 22, 2012Publication date: December 12, 2013Applicant: NNANOAXIS, LLCInventors: Krishnan Chakravarthy, Robert Spengler, Tracey Ignatowski, Siddhartha Kamisetti
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Publication number: 20130323182Abstract: The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.Type: ApplicationFiled: February 6, 2012Publication date: December 5, 2013Applicant: HANWHA CHEMICAL CORPORATIONInventors: Taeghwan Hyeon, Yuanzhe Piao, Yong Il Park
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Publication number: 20130315838Abstract: Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided.Type: ApplicationFiled: May 23, 2013Publication date: November 28, 2013Inventors: Philippe Reb, Celine Chaix, Meriadeg Thomas
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Publication number: 20130315839Abstract: Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.Type: ApplicationFiled: July 31, 2013Publication date: November 28, 2013Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Chulhyun LEE, Sung Lan JEON, Min Kyung CHAE, Jee-Hyun CHO, Eun Ju JANG
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Publication number: 20130309176Abstract: The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising: an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82% a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%, a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid; the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%; the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.Type: ApplicationFiled: December 20, 2011Publication date: November 21, 2013Applicants: UNIVERSITE DE BORDEAUX 1, GUERBETInventors: Marc Port, Caroline Robic, Fernando Leal Calderon, Samy Chadel
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Patent number: 8586095Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.Type: GrantFiled: August 29, 2006Date of Patent: November 19, 2013Assignee: Industrial Technology Research InstituteInventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
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Publication number: 20130302256Abstract: This invention discloses a synthetic procedure for preparing nanoparticulate materials of various metal cyanide compounds containing manganese(II) ions in the crystal lattice with the surfaces coated by a hydrophilic compound, and their use as MRI contrast agents with high sensitivity, long blood circulation half lives and low toxicity at low-field and high field MR scanners.Type: ApplicationFiled: August 29, 2011Publication date: November 14, 2013Applicant: KENT STATE UNIVERSITYInventors: Songping D. Huang, Anatoly K. Khitrin, Vindya S. Perera, Murthi S. Kandanapitiye
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Patent number: 8580230Abstract: A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T1-weighted and/or T2-weighted MRI contrast agents for imaging, including cellular imaging, in clinical diagnosis and biomedical research applications. The agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent.Type: GrantFiled: February 23, 2010Date of Patent: November 12, 2013Assignee: Kent State UniversityInventors: Songping D. Huang, Soumitra Basu, Anatoly K. Khitrin, Mohammadreza Shokouhimehr, Eric Scott Soehnlen
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Publication number: 20130295020Abstract: A radiopaque particulate material one or more of SiO2, TiO2, La2O3, Na2O and MgO and useful for embolization which optionally includes therapeutic components that are released in vivo.Type: ApplicationFiled: January 27, 2012Publication date: November 7, 2013Applicant: DALHOUSIE UNIVERSITYInventors: Robert J. Abraham, Sharon Kehoe, Daniel Boyd
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Patent number: 8574549Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: November 5, 2013Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
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Publication number: 20130287703Abstract: The present invention relates to a nanophosphor and a synthesis method thereof, and provides a nanophosphor comprising a first compound of Formula 1, wherein the first compound is fluoride-based one which is co-doped with Ce3+ and Tb3+. NaGd1?p?q?rMrF4:Ce3+p,Tb3+q ??(1) In the Formula 1, descriptions on the p, q, r and M are overlapped with what was described in the detailed description of the present invention, so their concrete description are omitted. The nanophosphor has good light emission intensity and magnetic property as well as up-conversion and/or down-conversion property able to emit visible light after excitation by infrared and/or ultraviolet rays, so can be applied to a contrast agent and a counterfeit prevention code.Type: ApplicationFiled: April 24, 2013Publication date: October 31, 2013Applicant: Korea Institute Of Science And TechnologyInventors: Ho Seong JANG, Kyoungja WOO, Kipil LIM
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Patent number: 8568690Abstract: The present invention provides an MRI contrast agent, comprising: MRI contrast agent particles, and oligonucleotides, attached to the particles.Type: GrantFiled: July 29, 2008Date of Patent: October 29, 2013Assignee: The Board of Trustees of the University of IllinoisInventors: Yi Lu, Mehmet Veysel Yigit, Debapriya Mazumdar
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Publication number: 20130280165Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumour, and a therapeutic composition comprising the microsphere, the powder, or the suspension.Type: ApplicationFiled: November 4, 2011Publication date: October 24, 2013Applicant: UMC Utrecht Holding B.V.Inventors: Wouter Bult, Johannas Franciscus Wilhelmus Nijsen, Alfred Drik Van het Schip
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Patent number: 8562953Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH2CH2Ol, and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.Type: GrantFiled: October 2, 2012Date of Patent: October 22, 2013Assignee: Industrial Technology Research InstituteInventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
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Publication number: 20130251641Abstract: The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.Type: ApplicationFiled: March 4, 2013Publication date: September 26, 2013Applicant: The Regents of the Universtiy of CaliforniaInventors: MASSOUD AKHTARI, JEROME ENGEL
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Patent number: 8540965Abstract: The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.Type: GrantFiled: July 31, 2006Date of Patent: September 24, 2013Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: David A. Scheinberg, Michael McDevitt, Christophe Antczak, Debjit Chattopadhyay, Rena May, Jón Njardarson, Mark Reid Philips
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Publication number: 20130243699Abstract: The design of biodegradable magnetic nanoparticles for use in in-vivo biomedical applications. The particles can include Fe in combination with one or more of Mg, Zn, Si, C, N, and P atoms or other particles. The nanoparticles can be degraded in-vivo after usage. The nanoparticles can cease heating upon reaching a predetermined temperature or other value.Type: ApplicationFiled: December 7, 2012Publication date: September 19, 2013Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Jian-Ping Wang, Ying Jing, Shihai He
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Publication number: 20130225979Abstract: The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated; (b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination.Type: ApplicationFiled: November 7, 2011Publication date: August 29, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Jörn Borgert, Ingo Schmale, Jürgen Erwin Rahmer, Bernhard Gleich, Michael Harald Kuhn
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Publication number: 20130224122Abstract: Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. Magnetospirillum magneticum AMB-1 produces positive MRI contrast when generating ultrasmall magnetite particles (10-40 nm diameter). Positive MRI contrast permits clearer distinction from image voids compared to negative contrast. T1-weighted MRI showed that such bacteria increased positive contrast 2.2-fold (p<0.02) in vitro and 2.0-fold (p<0.02) following intratumoral injection in mouse tumor xenografts. Upon intravenous delivery, Magnetospirillum magneticum AMB-1 targeted tumors and generated increased positive MRI contrast in them (1.4-fold; p<0.01). AMB-1 tumor targeting was shown by viable counts, microPET imaging of radio-labeled AMB-1, and Prussian blue staining of tumor sections. Thus, magnetotactic bacteria provide a tool for improving cancer diagnosis and monitoring treatment response by MRI.Type: ApplicationFiled: March 18, 2013Publication date: August 29, 2013Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: The Board of Trustees of the Leland Stanford Junior University
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Patent number: 8501159Abstract: There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.Type: GrantFiled: December 18, 2007Date of Patent: August 6, 2013Assignee: Colorobbia Italia S.p.A.Inventors: Giovanni Baldi, Daniele Bonacchi, Franco Innocenti, Giada Lorenzi, Marco Bitossi, Paolo Ferruti, Elisabetta Ranucci, Alfredo Ricci, Mauro Comes Franchini
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Publication number: 20130195767Abstract: A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.Type: ApplicationFiled: May 26, 2011Publication date: August 1, 2013Inventors: Ralph Weissleder, Hakho Lee, Tae-Jong Yoon
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Publication number: 20130177503Abstract: Methods are provided for the generation of nanostructures suitable for use in magnetic resonance imaging where the nanostructures have at least one dimension of about 2 nm or less. In particular, the methods comprise the selective use of incubation temperatures that result in the controlled removal of ligands from metallic cores to which they are attached, allowing the metallic cores or the precursor moieties to unite to form nanostructures of defined and predictable shapes, but having at least one dimension significantly less that at least one other dimension. Accordingly, the nanostructures of the disclosure may be ultrathin sheets, rods, whiskers and the like, or even structures that are thin and porous resembling rice grains. The temperatures useful in the methods of the disclosure are less than 300° C. and allow for progressive elevation of the incubation temperature.Type: ApplicationFiled: September 26, 2011Publication date: July 11, 2013Inventor: Yuping Y. Bao
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Patent number: 8475768Abstract: The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).Type: GrantFiled: August 12, 2008Date of Patent: July 2, 2013Assignee: GE Healthcare ASInventors: Oskar Axelsson, Harry John Wadsworth, Ian Martin Newington, Dennis O'Shea
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Publication number: 20130164222Abstract: Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.Type: ApplicationFiled: August 5, 2011Publication date: June 27, 2013Applicant: Hanwha Chemical CorporationInventors: Taeg Hwan Hyeon, Byung Hyo Kim, No Hyun Lee, Eung Gyu Kim, Bong Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
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Patent number: 8470892Abstract: A method for inducing neovascularization in which a pharmaceutically effective amount of polyethylene glycol (PEG) is injected into the tissue of the subject for purposes of accelerating wound healing and mimicking age related macular degeneration, cancer, tumors, and atherosclerosis for further research purposes.Type: GrantFiled: August 10, 2010Date of Patent: June 25, 2013Inventors: Puran S. Bora, Nalini S. Bora
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Publication number: 20130129633Abstract: Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.Type: ApplicationFiled: December 28, 2012Publication date: May 23, 2013Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventor: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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Publication number: 20130129632Abstract: The disclosure provides quantum dot materials, compositions and methods useful in the treatment of various disorders. In particular, the disclosure provides cadmium-free and lead-free quantum dots.Type: ApplicationFiled: October 3, 2012Publication date: May 23, 2013Inventors: Kam W. Leong, Chai-Hoon Quek
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Publication number: 20130115172Abstract: The present invention relates to a nanophosphor and method for synthesizing the same, and provides a nanophosphor containing fluoride-based nanoparticles co-doped with Yb3+ and Er3+ expressed by the following Chemical Formula 1, NaY1?w?z?x?yGdwLzF4:Yb3+x,Er3+y??(1) wherein, the description of the values x, y, w, z, and L is the same as defined above. The nanophosphor may exhibit an excellent luminous intensity despite having a small particle size, and be excited by infrared rays to emit visible light, and have magnetic properties and thus can be used as a contrast agent, a counterfeit prevention code, and the like.Type: ApplicationFiled: November 7, 2012Publication date: May 9, 2013Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventor: Korea Institute of Science and Technology
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Publication number: 20130108552Abstract: The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.Type: ApplicationFiled: February 24, 2011Publication date: May 2, 2013Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.Inventors: Parvesh Sharma, Scott Chang Brown, Niclas Bengtsson, Glenn A. Walter, Nobutaka Iwakuma, Edward W. Scott, Stephen R. Grobmyer, Swadeshmukul Santra, Brij M. Moudgil
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Patent number: 8420127Abstract: An injectable bone mineral substitute material composition with the capability of being hardened in a body fluid in vivo, which comprises at least one calcium phosphate component and at least one calcium sulfate component as a dry mixture mixed with an aqueous liquid, and at least one accelerator, the at least one calcium sulfate component being particulate hardened calcium sulfate, which has a specified particle size that is in order to confer injectability to the composition. The invention also concerns the bone mineral substitute material produced from the composition as well as methods and uses thereof.Type: GrantFiled: March 5, 2004Date of Patent: April 16, 2013Assignee: Bone Support ABInventors: Lars Lidgren, Malin Nilsson
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Publication number: 20130052140Abstract: This invention provides a Fe3O4/TiO2 composite nano-particle, its preparation and application in the magnetic resonance imaging (MRI) contrast agent, wherein the preparation of Fe3O4/TiO2 composite nano-particles has the followings steps: trivalent iron compounds and bivalent iron compounds are dissolved into a reducing acid water solution, and then added with tetravalent titanium salt solution to obtain the Fe3O4/TiO2 composite nano-particle sol. The Fe3O4/TiO2 composite nano-particles prepared by the method in the invention have the properties of superparamagnetism and photocatalytic activity and can be applied to MRI contrast agents.Type: ApplicationFiled: October 15, 2010Publication date: February 28, 2013Inventors: Leyong Zeng, Aiguo Wu, Ping Cui
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Patent number: 8383085Abstract: A method of making iron-containing nanoparticles (e.g., magnetite nanoparticles) that includes contacting an iron-containing precursor with a reducing agent at a temperature less than 200° C. and allowing the mixture to react to form magnetite nanoparticles.Type: GrantFiled: February 22, 2010Date of Patent: February 26, 2013Assignee: University of ManitobaInventors: Torsten Hegmann, Vinith Yathindranath, David F. Moore, Johan van Lierop
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Patent number: 8367040Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.Type: GrantFiled: April 20, 2012Date of Patent: February 5, 2013Assignee: Georgia State University Research Foundation, Inc.Inventors: Jenny Jie Yang, Zhi-Ren Liu
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Publication number: 20130023714Abstract: In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both.Type: ApplicationFiled: October 26, 2009Publication date: January 24, 2013Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMSInventors: Keith P. Johnston, Li L. Ma, Marc D. Feldman, Thomas E. Milner, Konstantin V. Sokolov, Jasmine Rowe, Justina Tam, Stanislav Emelianov, Kort Travis, Avinash K. Murthy
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Publication number: 20130017155Abstract: The invention relates to a new tungsten-iron-Ferritin nanoparticle and uses thereof in imaging.Type: ApplicationFiled: March 31, 2011Publication date: January 17, 2013Inventors: Kevin Bennett, Simon Lubek, Maria Veronia Clavijo-Jordan
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Patent number: 8349293Abstract: The invention relates to the use of metal nanoparticles for the preparation of a composition for diagnosing Alzheimer's disease by MRI.Type: GrantFiled: March 21, 2008Date of Patent: January 8, 2013Assignee: GuerbetInventor: Claire Corot
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Patent number: 8349294Abstract: Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature (Tg) of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.Type: GrantFiled: December 14, 2010Date of Patent: January 8, 2013Assignee: Novartis AGInventors: Luis A Dellamary, Jean Riess, Ernest G Schutt, Jeffry G Weers, Thomas E Tarara
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Patent number: 8323618Abstract: The present invention provides biomimetic contrast agents, dual functional contrast agents effective for therapeutic gene delivery and magnetic nanoparticles which comprise functionalized iron oxide nanoparticle cores, one of an inert gold layer, a layer of inert metal seeds or a silica layer and, optionally, one or both of an outer gold-silver nanoshell or a targeting ligand attached to the inert gold layer or the gold-silver nanoshell. Also provided are methods of in vivo magnetic resonance imaging, of treating primary or metastatic cancers or of ablating atherosclerotic plaque using the contrast agents and magnetic particles. In addition, kits comprising the biomimetic contrast agents, dual contrast agents and magnetic nanoparticles.Type: GrantFiled: February 11, 2009Date of Patent: December 4, 2012Assignee: University of Houston SystemInventor: Malavosklish Bikram
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Patent number: 8323621Abstract: Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancer cells, such as brain cancer, for improving resection of a cancerous tissue.Type: GrantFiled: March 4, 2008Date of Patent: December 4, 2012Assignees: Vanderbilt University, Texas Tech University SystemInventors: Darryl J. Bornhop, H. Charles Manning, Timothy Goebel
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Patent number: 8303937Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.Type: GrantFiled: July 16, 2008Date of Patent: November 6, 2012Assignee: Industrial Technology Research InstituteInventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
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Publication number: 20120276005Abstract: Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.Type: ApplicationFiled: April 3, 2012Publication date: November 1, 2012Inventors: David Yang, Dongfang Yu, Mithu Chanda, Ali Azhdarinia, Changsok Oh, E. Edmund Kim
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Publication number: 20120259154Abstract: The invention is a nano-entity conjugate for use in an in vivo immunomagnetic hyperthermia system for the detection and treatment of any cell or virus having a target surface receptor which encompasses a technology platform that can be used for both real-time monitoring of any cell or virus having a target surface receptor and as a delivery platform for certain types of treatment that are conducive for in vivo applications. The system allows of cell or virus enumeration; cell or virus capture; and cell or virus removal from the patient's circulatory system in-vivo using immunomagnetic hyperthermia. The application of immunomagnetic hyperthermia may actually diminish and eventually stop the progression of cancer and other blood borne or blood affected diseases.Type: ApplicationFiled: April 5, 2011Publication date: October 11, 2012Applicant: IVDiagnostics, Inc.Inventors: Bin Hong, Brian Markey
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Publication number: 20120258051Abstract: A composition comprising a core comprising an iron oxide, a first shell comprising at least one plasmon active metal at least partially surrounding the core, a second shell comprising a dielectric material at least partially surrounding the first shell, and a third shell comprising at least one plasmon active metal at least partially surrounding the second shell.Type: ApplicationFiled: October 27, 2011Publication date: October 11, 2012Inventors: Charleson S. Bell, Shann Yu
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Publication number: 20120251443Abstract: The present disclosure provides compositions and methods based on implantable contrast agents that are useful for imaging tissue and organs.Type: ApplicationFiled: October 1, 2010Publication date: October 4, 2012Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: C. Keith Ozaki, Jeffrey M. Karp, Frank Rybicki, Dimitrios Mitsouras, Praveen Kumar Vemula
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Publication number: 20120219508Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.Type: ApplicationFiled: February 1, 2012Publication date: August 30, 2012Inventors: SHYH-DAR LI, Mark John Ernsting, Wei-Lun Tang
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Publication number: 20120201759Abstract: Hierarchical nanostructures and methods of fabrication. The structures include particles having a metal oxide outer shell with metal oxide wires extending from the outer shell. A multiscale structure according to the invention has particles above and below a critical size wherein the particles above the critical size have wires extending from the surface. These structures may be fabricated from a mixture prepared of relatively smaller metal particles having a size threshold below a threshold for nanowire formation and of relatively larger metal particles having a size above the threshold for nanowire formation. The mixture is oxidized at a selected temperature and for a selected time whereby the relatively smaller particles sinter and nanowires grow on the relatively larger particles thereby creating tunable hierarchical structures with metal-to-metal contact between the particles.Type: ApplicationFiled: February 1, 2012Publication date: August 9, 2012Applicant: Massachusetts Institute of TechnologyInventors: Christopher Jameson Love, J. David Smith, Kripa K. Varanasi
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Publication number: 20120195835Abstract: A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle.Type: ApplicationFiled: January 27, 2012Publication date: August 2, 2012Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kyoungja WOO, Myung-Ik YOO
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Publication number: 20120197115Abstract: The invention relates to the discrimination of spectroscopically different tracer materials by magnetic particle imaging (MPI), based on the differences of the MPI spectral responses of said tracer materials.Type: ApplicationFiled: October 11, 2010Publication date: August 2, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Peter Leonardus Elisabeth Maria Pasmans, Denis Markov
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Publication number: 20120190975Abstract: The present invention relates to diagnostic and therapeutic nanoparticles. More particularly, the present invention relates to creating a copper (Cu)-based nanoparticle and a method for making the same. The Cu-based nanoparticles can further be incorporated with additional therapeutic or diagnostic compounds and used for the diagnosis and treatment of tumors.Type: ApplicationFiled: June 22, 2011Publication date: July 26, 2012Applicant: The Board of Regents of the University of Texas SystemInventors: Wei Chen, Yuebin Li