Abstract: The invention relates to the use of dispersions of magneto-ionic particles consisting essentially of superparamagnetic solid particles and at least one polyelectrolyte as dispersing substance in water for the preparation of an MRI contrast medium.
Type:
Grant
Filed:
February 28, 1995
Date of Patent:
June 26, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Claudius Kormann, Michel Robert Anseau, Robert Nicolas Henry Muller
Abstract: Microspheres, having a size lower than 1&mgr; and comprising a biocompatible polysaccharidic polymer, are prepared with a process comprising the precipitation of polymer induced by means of a supercritical antisolvent (SAS). These microspheres are used as vehicling agents or carriers in the preparation of pharmaceutical compositions administrable by oral, nasal, pulmonary, vaginal or rectal route. These microspheres can also be advantageously used as vehicling agent or carriers in the preparation of pharmaceutical compositions for the treatment of human diseases associated with genic defects, for the preparation of diagnostics and in the agro-alimentary industry.
Type:
Grant
Filed:
September 26, 1997
Date of Patent:
April 10, 2001
Assignee:
Fidia Advanced Biopolymers S.r.l.
Inventors:
Paolo Pallado, Luca Benedetti, Lanfranco Callegaro
Abstract: The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast agents are provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.
Type:
Grant
Filed:
February 3, 1999
Date of Patent:
March 27, 2001
Assignee:
Nycomed Imaging AS
Inventors:
Anne Kjersti Fahlvik, Anne Nævestad, Helge Gundersen, Per Strande, Jo Klaveness, Anne Jacobsen
Abstract: In a method of contrast MR imaging, using parenterally administered contrast agents, the improvement comprising using as the contrast agent, e.g. to achieve a negative contrast effect, composite particles comprising a biotolerable, carbohydrate or carbohydrate derivative, preferably polymeric, matrix material containing magnetically responsive particles, eg. of magnetite.
Abstract: The invention provides a marker whose position in a cavity inside of a living organism can be determined, in particular for detecting local passage speeds of the marker through the gastro-intestinal tract, preferably in the small intestinal tract. The object of the invention is to provide a marker whose magnetization can be reversed with relatively low field intensities. To that end, the marker consists of a first substantially spherical part which contains a magnetizable material and is surrounded on all sides by a second part which is provided with a substantially spherical receptacle adapted to the surface shape of the first part, the receptacle being filled with a low-viscosity fluid.