Bacteria Or Actinomycetales Patents (Class 424/93.4)
  • Patent number: 11071760
    Abstract: Provided herein are novel Lactobacillus fermentum strains, NRRL B-67059 or NRRL B-67060, compositions containing the NRRL B-67059 or NRRL B-67060 strains, and fermented dairy products and bioactive compounds prepared using the NRRL B-67059 or NRRL B-67060 strains. Also provided are methods of modulating the immune system of a subject.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: July 27, 2021
    Assignee: Dairy A Day Inc.
    Inventors: Belinda Vallejo Galland, Aarón Fernando González Córdova, José Antonio Feregrino Quezada, Juan Carlos Feregrino Quezada
  • Patent number: 11052097
    Abstract: The present invention relates to the use of a galactooligosaccharide composition for preventing or reducing the risk of developing metabolic syndrome.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: July 6, 2021
    Inventors: Georgios Tzortzis, Jelena Vulevic
  • Patent number: 11045501
    Abstract: The present disclosure relates to the use of autologous fecal samples obtained from a subject for use in prevention and/or treatment of microbial dysbiosis in the gastrointestinal tract in said subject and to related pharmaceutical compositions for oral administration. The disclosed autologous fecal samples are useful for treatment of microbial dysbiosis in the gastrointestinal tract associated with medical treatment and/or various indications, including chronic disease and infectious disease, for example Clostridium difficile infection.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 29, 2021
    Assignee: BACTAVIVA AB
    Inventors: Hans Peter Torsten Ekre, Lars Georg Engstrand, Ola Gosta Flink, Otto Sten Gunnar Skolling
  • Patent number: 11045505
    Abstract: A media supplement for culturing anaerobic bacteria is provided which comprises a filtrate of eilluent from a chemostat vessel in which a target bacterial ecosystem has been culnn-ed. Methods of using the supplement for culturing or isolating anaerobic microbial strains or cormmmities, particularly anaerobic bacteria from the human gut, are also provided.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: June 29, 2021
    Assignee: NUBIYOTA LLC
    Inventors: Emma Allen-Vercoe, Julie McDonald
  • Patent number: 11040077
    Abstract: Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: June 22, 2021
    Assignee: DermBiont, Inc.
    Inventors: Robert M. Brucker, Xuecheng Zhang, Ida Lister, Sanjay Jain
  • Patent number: 10973841
    Abstract: Described herein are methods and compositions for the treatment of skin conditions associated the dysbiosis. Further described herein is the use of metabolites for treatment of dysregulated microbiota in a subject. Such metabolites can be produced by microorganisms present in a higher abundance in the skin of healthy subjects as compared to the skin of a subject having dysbiosis of the skin. In addition, compositions and methods provided herein describe the use of metabolites as part of a combination therapy.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: April 13, 2021
    Assignee: FORTE SUBSIDIARY, INC.
    Inventor: Paul Wagner
  • Patent number: 10973862
    Abstract: Bifidobacterium longum AH1362 (NCIMB 41715) produces a polysaccharide and increases energy excretion. The strain is used in the prevention or treatment of obesity and obesity-related metabolic syndrome.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 13, 2021
    Assignee: PrecisionBiotics Group Limited
    Inventors: Barry Kiely, Eileen Frances Murphy, Selena Healy
  • Patent number: 10925953
    Abstract: The invention relates to compositions and methods for treating inflammatory diseases and disorders in a subject in need thereof. In certain aspects, the invention relates to immunogenic compositions (e.g., vaccines) to diminish the number or pathogenic effects of one or more bacteria associated with the development or progression of an inflammatory disease or disorder.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 23, 2021
    Assignee: Yale University
    Inventors: Richard Flavell, Noah Palm, Marcel De Zoete
  • Patent number: 10912802
    Abstract: The present invention is intended for the use of a probiotic composition comprising Bifidobacterium animalis subs. lactis (B. lactis), Bifidobacterium longum and Lactobacillus rhamnosus, in particular the strains B. lactis CECT 8145, B. longum ES1 CECT 7347 and/or L. rhamnosus CECT 8361, in the treatment and/or prevention of psoriasis outbreaks or psoriasis.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: February 9, 2021
    Assignees: Bionou Research, S.L., KOROTT, S.L., BIOPOLIS, S.L.
    Inventors: Vicente Manuel Navarro López, Ana Adela Ramírez Boscá, José Manuel Pérez Orquín, Daniel Ramón Vidal, Salvador Genovés Martínez, María Empar Chenoll Cuadros, Francisco Manuel Codoñer Cortés
  • Patent number: 10857189
    Abstract: A method for preventing and/or treating vitamin B12 deficiency is taught. The method comprises administering a composition comprising pseudovitamin B12-producing bacteria, optionally in conjunction with mucin-degrading and/or propionate-producing bacteria, to a subject in need thereof. The method is particularly suitable for administration to subjects suffering from vitamin B12 deficiency due to metformin treatment for type-2 diabetes, and to subjects having undergone bariatric surgery.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: December 8, 2020
    Assignee: Caelus Pharmaceuticals B.V.
    Inventor: Willem Meindert De Vos
  • Patent number: 10851027
    Abstract: Endophytic microbial strains as biocatalysts isolated from fresh plant samples, compositions, and methods of use thereof to enhance the growth and/or yield of a plant in the presence of reduced synthetic phosphate fertilizers are provided. Endophytic microbial strains serve as biocatalysts to solubilize mineral-P and mineralize organic-P otherwise unavailable to plants for their nutritional phosphate needs. Thus defined, biocatalysts, will serve to replace synthetic phosphate fertilizers. Also provided are materials and methods for inoculating plants with these biocatalysts at carefully selected inoculum densities to reliably reduce the amount of synthetic phosphate fertilizer by 50% thus accomplishing obtaining optimal yields in technically and cost-effective manner.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: December 1, 2020
    Assignee: Biomineral Systems LLC
    Inventor: Nadia Adam
  • Patent number: 10842737
    Abstract: A formulation for vaginal administration comprising an effective amount of a composition of dried Lactobacillus cells and boric acid, with a carrier. The composition can include one or more antioxidants. Optionally, the composition is in a unit dosage form. Also provided are methods for making and using the composition.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: November 24, 2020
    Assignee: GRACE PROCUREMENTS LLC
    Inventor: Allison Krebs-Bensch
  • Patent number: 10842829
    Abstract: A natural product for improving health and reducing the risk of death due to dangerous diseases comprises a presence of figs and Acetobacter pasteurianus.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: November 24, 2020
    Inventor: Malek Al Soud
  • Patent number: 10821124
    Abstract: The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide for use in preventing and/or treating constipation and/or in improving stool consistency/frequency in an infant or a young child.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Norbert Sprenger, Dominique Brassart, Delphine Egli
  • Patent number: 10806759
    Abstract: Provided are Christensenella intestinihominis and an application thereof, specifically, use of Christensenella intestinihominis in treating and preventing obesity and related diseases thereof. Also provided are a composition for treating and preventing obesity and related diseases thereof, comprising compositions of drugs, drinks, food, or animal feed, and a method for reducing weight and/or blood lipid.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: October 20, 2020
    Assignee: BGI SHENZHEN
    Inventors: Yuanqiang Zou, Wenbin Xue, Mei Lv, Liang Xiao, Xiaoping Li, Jinghong Yu, Chuan Liu
  • Patent number: 10787716
    Abstract: A spore-forming Bacillus species, and more particularly, a Bacillus subtilis strain identified as MB40 is provided. Compositions comprising the MB40 strain, methods of making products comprising the same, and methods of using the same are also provided.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: September 29, 2020
    Assignee: BIO-CAT, INC.
    Inventors: Christopher S. Penet, Sebhat Gebrechristos, Caroline Helen Best, Deborah S. Winetzky, Robert Daniel Little, Jr., Jessica Spears, Christopher Schuler
  • Patent number: 10780103
    Abstract: A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: September 22, 2020
    Assignee: GLYCOM A/S
    Inventors: Bruce McConnell, Emma Elison, Louise Kristine Vigsnæs
  • Patent number: 10750744
    Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: August 25, 2020
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventor: Chunhua Yang
  • Patent number: 10751322
    Abstract: The therapeutic use of bacteria, specifically but not only lactobacilli, which produce indole-3-aldehyde, or directly of indole-3-aldehyde itself, is proposed as a means of prevention and treatment of immune dysreactive disorders in which the hyper-inflammatory or autoimmune component represents the basic element.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: August 25, 2020
    Assignee: Universita′ degli Studi di Perugia
    Inventors: Luigina Romani, Paolo Puccetti, Teresa Zelante, Maurizio Ricci, Stefano Giovagnoli
  • Patent number: 10744167
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: August 18, 2020
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Patent number: 10738275
    Abstract: Provided are a new Paenibacillus sp. strain, the deposit number of which is CGMCC No. 8333, and a method for culturing the exopolysaccharide; and an exopolysaccharide having a structural formula as shown in formula (I) being produced by the strain, as well as a production method thereof and its use in promoting the propagation of bifidobacterium. The exopolysaccharide shown by formula (I) has a moderate degree of polymerization (DP=15-30) and has the functions of promoting the propagation of bifidobacterium, as well as adjusting human intestinal microflora.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: August 11, 2020
    Assignee: BRIGHT DAIRY & FOOD CO., LTD.
    Inventors: Zhengjun Wu, Benheng Guo, Caixia Gao, Zhenmin Liu, Feng Hang, Jin Han
  • Patent number: 10736926
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: August 11, 2020
    Assignee: 4D Pharma Research Limited
    Inventors: George Grant, Angela Margaret Patterson, Imke Mulder, Seanin McCluskey, Emma Raftis
  • Patent number: 10736849
    Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 11, 2020
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Audrey Chapron, Fernanda Fonseca, Olivier David
  • Patent number: 10695427
    Abstract: The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors with or without chemotherapeutic agents for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 30, 2020
    Assignee: The Johns Hopkins University
    Inventors: Qiongyu Guo, Jordan J. Green, Randall A. Meyer, Corey J. Bishop, Anand Kumar, Gregg L. Semenza
  • Patent number: 10682389
    Abstract: The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: June 16, 2020
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN, UNIVERSITÉ´DE ROUEN, TARGEDYS
    Inventors: Sergueï Fetissov, Pierre Dechelotte, Jonathan Breton, Gregory Lambert, Romain Legrand
  • Patent number: 10675312
    Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: June 9, 2020
    Assignee: Pendulum Therapeutics, Inc.
    Inventors: Colleen Cutcliffe, John S. Eid, James H. Bullard, Marcus F. Schicklberger
  • Patent number: 10617725
    Abstract: Provided is a composition containing Bifidobacterium for alleviating, preventing or treating rheumatoid arthritis. The Bifidobacterium bifidum ATT newly isolated according to the present invention is useful as a rheumatoid arthritis medicine or a probiotic material for alleviating rheumatoid arthritis owing to potent efficacy in treating rheumatoid arthritis.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 14, 2020
    Assignees: BIFIDO CO., LTD., THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Geun Eog Ji, Yunju Jeong, Hui Fang, Bin Kwon, Sung-Hwan Park, Mi-La Cho, Ji-Hyeon Ju, Seung-Ki Kwok, Jennifer Lee, Ji-Won Kim, Seon-Yeong Lee, Jun-Geol Ryu, Joo-Yeon Jhun, Jae-yoon Ryu, Hyeon-Beom Seo
  • Patent number: 10568946
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: February 25, 2020
    Assignee: OXTHERA INTELLECTUAL PROPERTY AB
    Inventors: Harmeet Sidhu, Aaron Blake Cowley, Carl-Gustaf Golander, Qingshan Li
  • Patent number: 10555975
    Abstract: This document provides methods and materials related to Prevotella histicola preparations. For example, Prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided. In addition, methods and materials for using a Prevotella histicola preparation provided herein as an anti-inflammatory agent are provided.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 11, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph A. Murray, Eric V. Marietta, Susan H. Barton, Veena Taneja, Ashutosh Mangalam
  • Patent number: 10517906
    Abstract: The invention relates to the fields of application of health, biotechnology and nutrition, the aim of the invention being to provide a gelatinous mixture of probiotics and prebiotics with synergic symbiotic action for the treatment of chronic renal disease, the characteristics and components thereof reducing the concentration of uremic toxins, improving the renal function of the patient with an increase in urea, creatinine, uric acid, p-cresols or indoles in the blood. The gelatinous mixture of probiotics and prebiotics with synergic symbiotic action for the treatment of chronic renal disease is easier to administrate orally as it does not require the consumption of liquids for the administration thereof, reducing liquid retention. Another advantage of the present invention is the fact that it refers to live and active bacteria. The present invention is also used a primary source of food with known prebiotic effects, an element which is not considered in other inventions; it is not in a pharmaceutical form.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: December 31, 2019
    Assignee: NUTRIMENTOS INTELIGENTES, S.A. DE C.V.
    Inventors: Fabiola Martín Del Campo López, Luis Gerardo Gonzalez Delgado, Daniela Viramontes Horner, Guillermo García García, Julio Alberto Ramos De La Mora
  • Patent number: 10463724
    Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 5, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vincent K. Tuohy, Justin M. Johnson, Ritika Jaini
  • Patent number: 10413577
    Abstract: Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 17, 2019
    Assignee: The Regents of the University of California
    Inventors: Mitsuko L. Yamamoto, Robert H. Schiestl, Ramune Reliene, James Borneman, Laura L. Presley, Jonathan Braun
  • Patent number: 10405555
    Abstract: Provided are bioactive compounds and metabolites derived from Chromobacterium species culture responsible for controlling pests, compositions containing these compounds, methods for obtaining these compounds and methods of using these compounds and compositions for controlling pests.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: September 10, 2019
    Assignee: MARRONE BIO INNOVATIONS, INC.
    Inventors: Ratnakar Asolkar, Huazhang Huang, Marja Koivunen, Pamela Marrone
  • Patent number: 10362787
    Abstract: The present invention relates to methods of scalably producing microorganisms by propagating them within plant tissues and introducing them into agricultural seeds to improve their shelf-life during long-term storage, to produce substances of interest, and to create libraries of microbes.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: July 30, 2019
    Assignees: AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH, INDIGO AG, INC.
    Inventors: Birgit Mitter, Muhammad Naveed, Teresa Berninger, Stephane Compant, Angela Sessitsch, Geoffrey Von Maltzahn, Richard Bailey Flavell, Gerardo V. Toledo, Slavica Djonovic, Luis Miguel Marquez, David Morris Johnston, Yves Alain Millet, Jeffrey Lyford, Jonathan W. Leff, Phillip Samayoa, Craig Sadowski
  • Patent number: 10357506
    Abstract: The present invention relates to a composition comprising at least one fucosylated oligosaccharide, for use in preventing and/or treating URT infections in an infant or young child fulfilling at least one of the following criteria: i) the infant or young child is born from a non-secretor mother and/or is fed with a mother's milk deficient in at least one fucosylated oligosaccharide(s) ii) the infant or young child has at least one sibling iii) the infant or young child was born by C-section.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: July 23, 2019
    Assignee: Nestec S.A.
    Inventors: Norbert Sprenger, Clemens Kunz, Dominique Brassart
  • Patent number: 10350249
    Abstract: Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 16, 2019
    Assignee: The Regents of the University of California
    Inventors: David A. Mills, Steven A. Frese
  • Patent number: 10323227
    Abstract: Disclosed herein is a composition containing turmeric starch for use as a prebiotic plant fiber. Also disclosed is a method to increase the viable counts of Bacillus coagulans MTCC 5856 by co-culturing with turmeric starch and the production of short chain fatty acids (SCFA) by Bacillus coagulans MTCC 5856 using turmeric starch.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: June 18, 2019
    Assignee: SAMI LABS LIMITED
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali
  • Patent number: 10316302
    Abstract: The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ?-lactam antibiotics.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: June 11, 2019
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA
    Inventors: Ana María Otero Casal, Manuel Romero Bernárdez, Celia Mayer Mayer
  • Patent number: 10316368
    Abstract: Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis).
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 11, 2019
    Assignees: Northwestern University, The Board of Trustees of the University of Illinoi
    Inventors: David J. Klumpp, Anthony J. Schaeffer, Bryan A. White
  • Patent number: 10293008
    Abstract: Disclosed herein is (i) a method related to the growth promotional activity of plant based fibers on Bacillus coagulans MTCC 5856; (ii) the combination of plant based fibers and Bacillus coagulans MTCC 5856 to inhibit Gram Negative pathogenic bacteria; and (iii) the production of short chain fatty acids (SCFA) by Bacillus coagulans MTCC 5856 using plant based fibers.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 21, 2019
    Assignee: SAMI LABS LIMITED
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali
  • Patent number: 10293006
    Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial consortia, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and compositions comprising the same, in methods for modulating the production and yield of milk and milk components in ruminants. In particular aspects, the disclosure provides methods of increasing desirable components of milk in ruminants. Furthermore, the disclosure provides for methods of modulating the rumen microbiome.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: May 21, 2019
    Assignee: Ascus Biosciences, Inc.
    Inventors: Mallory Embree, Luke Picking, Grant Gogul, Janna Tarasova
  • Patent number: 10286017
    Abstract: Selection of probiotic strains belonging to the genus Bifidobacterium and to a symbiotic composition containing the same for use of feeding infants, is described.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: May 14, 2019
    Assignee: PROBIOTICAL S.P.A.
    Inventors: Giovanni Mogna, Gian Paolo Strozzi, Luca Mogna
  • Patent number: 10258567
    Abstract: A formulation for vaginal administration comprising an effective amount of a composition of dried Lactobacillus cells and boric acid, with a carrier. The composition can include one or more antioxidants. Optionally, the composition is in a unit dosage form. Also provided are methods for making and using the composition.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 16, 2019
    Assignee: GRACE PROCUREMENTS LLC
    Inventor: Allison Krebs-Bensch
  • Patent number: 10238745
    Abstract: A cannabinoid composition having an excipient including ?-tocopherol and at least one isolated cannabinoid having a purity of greater than 80%. The ?-tocopherol inhibits oxidation, regulates viscosity of the composition, and improves bioavailability of the cannabinoid. The composition includes a carrier oil mixed with the excipient and cannabinoid. In one embodiment, the at least one cannabinoid is an isolated cannabinoid having a greater than 80% purity, and preferably greater than 90% purity. The at least one cannabinoid is selected from the group consisting of phytocannabinoids, endocannabinoids, synthetic cannabinoids, and combinations thereof. The cannabinoid may be derived from plants other than cannabis sativa, or synthesized from fungi, bacteria, yeast or other synthetic method. Preferably the ?-tocopherol comprises at least 10% w/w of the composition.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: March 26, 2019
    Assignee: Constance Therapeutics, Inc.
    Inventors: Constance Finley, Luke McKee
  • Patent number: 10173936
    Abstract: An IBTL system having a low GHG footprint for converting biomass to liquid fuels in which a biomass feed is converted to liquids by direct liquefaction and the liquids are upgraded to produce premium fuels. Biomass residues from the direct liquefaction, and optionally additional biomass is pyrolyzed using microwave pyrolysis to produce structured biochar, hydrogen for the liquefaction and upgrading, and CO2 for conversion to algae, including blue green algae (cyanobacteria) in a photobioreactor (PBR). Produced algae and diazotrophic microorganisms are used to produce a biofertilizer that also contains structured biochar. The structured biochar acts as a nucleation agent for the algae in the PBR, as a absorption agent to absorb inorganics from the biomass feed to direct liquefaction or from the liquids produced thereby, and as a water retention agent in the biofertilizer.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 8, 2019
    Assignees: ACCELERGY CORPORATION, SHANGHAI ADVANCED RESEARCH INSTITUTE OF THE CHINESE ACADEMY OF SCIENCE
    Inventors: Rocco A Fiato, Yuhan Sun, Mark Allen, Quanyu Zhao
  • Patent number: 10165788
    Abstract: Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: January 1, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: David Mills, Daniel Garrido, Santiago Ruiz-Moyano, Carlito Lebrilla, J. Bruce German
  • Patent number: 10130664
    Abstract: The present invention relates probiotic compositions useful in accelerating alcohol catabolism in a subject.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: November 20, 2018
    Assignee: BiOWiSH Technologies, Inc.
    Inventors: Richard Carpenter, Amit Kapur, E. Wesley Huff, Narayan Suresh
  • Patent number: 10117827
    Abstract: Provided is a tear-free formulation for suppressing or reducing ocular irritancy of a pre-made cosmetic or therapeutic formulation or an ophthalmic formulation suitable for application to an eye of a subject or to a skin region surrounding an eye of a subject.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: November 6, 2018
    Assignee: Y&B MOTHER'S CHOICE LTD.
    Inventors: Rachel Lutz, Alexander Besonov, Tova Silberstein
  • Patent number: 10113145
    Abstract: Provided are a new Paenibacillus sp. strain, the deposit number of which is CGMCC No. 8333, and a method for culturing the exopolysaccharide; and an exopolysaccharide having a structural formula as shown in formula (I) being produced by the strain, as well as a production method thereof and its use in promoting the propagation of bifidobacterium. The exopolysaccharide shown by formula (I) has a moderate degree of polymerization (DP=15-30) and has the functions of promoting the propagation of bifidobacterium, as well as adjusting human intestinal microflora.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 30, 2018
    Assignee: BRIGHT DAIRY & FOOD CO., LTD
    Inventors: Zhengjun Wu, Benheng Guo, Caixia Gao, Zhenmin Liu, Feng Hang, Jin Han
  • Patent number: RE48308
    Abstract: An IBTL system having a low GHG footprint for converting biomass to liquid fuels in which a biomass feed is converted to liquids by direct liquefaction and the liquids are upgraded to produce premium fuels. Biomass residues from the direct liquefaction, and optionally additional biomass is pyrolyzed using microwave pyrolysis to produce structured biochar, hydrogen for the liquefaction and upgrading, and CO2 for conversion to algae, including blue green algae (cyanobacteria) in a photobioreactor (PBR). Produced algae and diazotrophic microorganisms are used to produce a biofertilizer that also contains structured biochar. The structured biochar acts as a nucleation agent for the algae in the PBR, as a absorption agent to absorb inorganics from the biomass feed to direct liquefaction or from the liquids produced thereby, and as a water retention agent in the biofertilizer.
    Type: Grant
    Filed: December 15, 2019
    Date of Patent: November 17, 2020
    Assignees: ACCELERGY CORPORATION, SHANGHAI ADVANCED RESEARCH INSTITUTE OF THE CHINESE ACADEMY OF SCIENCE
    Inventors: Rocco A Fiato, Yuhan Sun, Mark Allen, Quanyu Zhao