Bacteria Or Actinomycetales Patents (Class 424/93.4)
  • Patent number: 11884952
    Abstract: The present invention provides a novel daptomycin-producing Streptomyces strain and use thereof, the strain is a subspecies of streptomyces griseus, named Streptomyces griseus L340, and the preservation number is CGMCC17921. The genetic character and fermentation unit of the strain provided by the present invention are relatively stable, the culture and fermentation conditions are suitable for industrial production of daptomycin, and the interference of pigment in later separation and purification is eliminated. The secondary metabolite daptomycin is obtained through fermentation of the Streptomyces provided by the present invention, which has the advantages of no interference of pigment accumulation, cleaner metabolic spectrum and thus is obviously superior in later separation and purification.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: January 30, 2024
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yongquan Li, Jiaole Fang, Xuming Mao, Xinai Chen
  • Patent number: 11865145
    Abstract: The present invention relates to, in part, compositions and methods for delivery of novel mixtures of bacterial strains for maintaining and/or restoring a healthy gut barrier.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 9, 2024
    Assignee: Finch Therapeutics Holdings LLC
    Inventors: Marina Santiago, Kevin Roelofs
  • Patent number: 11845948
    Abstract: Disclosed herein are the nucleotide sequences of the Chromobacterium subtsugae genes. In addition, the amino acid sequences of proteins encoded by the C. subtsugae genes are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, functional fragments and conservative variants of the aforementioned sequences are also provided. Compositions having pesticidal, bioremedial and plant growth-promoting activities comprising C. subtsugae genes and proteins, and methods for the use of these compositions, are also provided.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: December 19, 2023
    Assignee: Pro Farm Group, Inc.
    Inventors: Ana Lucia Cordova-Kreylos, Scott Burman, Debora Wilk
  • Patent number: 11844816
    Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: December 19, 2023
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona University
    Inventors: Cindy Liu, Lance B. Price
  • Patent number: 11825862
    Abstract: The disclosure relates to isolated microorganisms-including novel strains of the microorganisms-microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial ensembles, and compositions comprising the same, in methods for modulating the production of poultry, disease resistance, and egg yield. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of preventing colonization of pathogenic microbes.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: November 28, 2023
    Assignee: Native Microbials, Inc.
    Inventors: Mallory Embree, Grant Gogul, Cameron Martino, Norm Pitt
  • Patent number: 11760971
    Abstract: Methods for improving the ability of a population of biological agents to compete and survive in a field setting are provided. The modified population of agents is able to grow, compete with other microbial strains and fungi, and provide protection for plants from pathogens. Modified biological agents and modified populations of such agents that are herbicide tolerant or resistant are selected or engineered. In this manner, the protection from disease-causing agents is enhanced. Such modified populations can be added to soils to prevent fungal pathogens and associated diseases, promoting plant growth. The present invention is useful for enhancing the competitiveness of modified biological agents particularly over other microbial agents which are not herbicide resistant. Compositions include selected or engineered herbicide resistant biological agents and modified populations of biocontrol agents. These modified biological agents can be used as an inoculant or as a seed coating for plants and seeds.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: September 19, 2023
    Assignee: AgBiome, Inc.
    Inventors: Philip E. Hammer, Janice C. Jones, Michael G. Koziel, Scott Joseph Uknes
  • Patent number: 11758924
    Abstract: The subject invention provides compositions and methods for reducing deleterious atmospheric gases and/or precursors thereof using livestock feed additives and/or supplements. In preferred embodiments, a multi-purpose composition comprising one or more beneficial microorganisms and/or one or more microbial growth by-products is applied to livestock animals' feed and/or to a field or pasture where livestock animals graze. In some embodiments, the composition controls methanogenic bacteria. In some embodiments, the composition enhances carbon sequestration in the field or pasture by promoting plant health and/or growth.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: September 19, 2023
    Assignee: LOCUS SOLUTIONS IPCO, LLC
    Inventors: Sean Farmer, Ken Alibek
  • Patent number: 11752179
    Abstract: The present invention relates to the use of a composition based on bacteria and/or yeasts and/or other microorganisms, taken singularly or in combination, for the treatment of abdominal pain by administering to a patient suffering from Irritable Bowel Syndrome (IBS). In particular, the bacteria comprise Lactobacillus paracasei DG strain deposited with the deposit number CNCMI 1572.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: September 12, 2023
    Assignee: ALFASIGMA S.P.A.
    Inventors: Andrea Biffi, Walter Fiore, Ruggero Rossi
  • Patent number: 11744867
    Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: September 5, 2023
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson
  • Patent number: 11737466
    Abstract: The present invention provides a method of improving the ability of plants to resistance diseases, comprising using a strain of Bacillus amyloliquefaciens and a Bidens plant extract; and the Bidens plant extract enhances the ability of the Bacillus amyloliquefaciens to inhibit the growth of the Acidovorax avenae subsp. citrulli, increases the metabolic activity of the Bacillus amyloliquefaciens, increases the amount of the biofilm formation of the Bacillus amyloliquefaciens, and maintains the alive number of the Bacillus amyloliquefaciens.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: August 29, 2023
    Assignees: NATIONAL TAIWAN UNIVERSITY, ACADEMIA SINICA
    Inventors: Chi-Te Liu, Wen-Chin Yang, Yen-Yu Liu, Chu-Ning Huang, Chan-Pin Lin
  • Patent number: 11730971
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: August 22, 2023
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Jon P. Dobson, Josephine Allen
  • Patent number: 11730775
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: August 22, 2023
    Assignee: Seres Therapeutics, Inc.
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey Von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Patent number: 11702454
    Abstract: The present invention belongs to the field of biotechnology, in particular to a multivalent fusion protein AB-NAC-189, method for producing the same, and uses thereof. The protein AB-NAC-189 is a fusion of a polypeptide segment AB, nascent polypeptide-associated complex (NAC), and a protein 189 corresponding to amino acids 1-189 from the N-terminal of protein HarpinEa. The fusion has the properties of a multivalent plant immune protein, thus it can effectively stimulate the hypersensitive response of tobacco leaves and has good thermal stability. While stimulating the immune response of plants, it can also improve the disease resistance of plants and promote plant growth. The AB-NAC-189 multivalent vaccine shows higher activity per unit concentration, and greater ability to promote growth of wheat and tobacco; meanwhile it can significantly promote chlorophyll synthesis in Goji berry, thereby improving the yield and quality of Goji berries.
    Type: Grant
    Filed: October 17, 2021
    Date of Patent: July 18, 2023
    Assignee: Suzhou Yishuimo Biological Technology Co., LTD
    Inventors: Aiyou Sun, Zhong Wang, Zengying Cai, Qun Yu, Zhiwei Li, Bing Sun, Chong Zhang, Shiyue Miao
  • Patent number: 11696921
    Abstract: A human milk oligosaccharide (HMO) or a synthetic composition comprising said HMO, for use in increasing the abundance, particularly the relative abundance, of a Bifidobacterium of the B. adolescentis phylogenic group in the microbiota in the gastro-intestinal tract of a human, preferably a non-infant human. The HMO(s) and/or synthetic composition is useful in; increasing particularly the relative abundance of B. adolescentis and/or B. pseudocatenulatum; for treating or preventing in said non-infant human with type 2 diabetes and/or obesity; an enteropathogenic infection; impaired gut barrier function and/or; an inflammation related to gastro¬intestinal condition, preferably irritable bowel disease (IBD) or irritable bowel syndrome (IBS); as a nutritional composition. The HMO is a fucosylated neutral HMO, a non-fucosylated neutral HMO, or a mixture of a fucosylated and a non-fucosylated neutral HMO.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: July 11, 2023
    Assignee: GLYCOM A/S
    Inventors: Louise Kristine Vigsnæs, Bruce McConnell
  • Patent number: 11684633
    Abstract: A method is provided for preventing and/or treating heart failure in a subject in need thereof by administering to the subject a therapeutically effective amount of polydextrose. The method may also include the use of polydextrose for preventing cardiac remodeling and/or ventricle dilatation and/or for preventing systolic dysfunction, as well as preventing an increase in bacterial translocation to heart tissue in a subject who suffered from a myocardial infarction.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: June 27, 2023
    Assignees: VAIOMER, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Christophe Heymes, Rémy Burcelin, Benjamin Lelouvier, Jacques Amar
  • Patent number: 11638729
    Abstract: The invention relates to prevention of insulin resistance or low-grade chronic inflammation later in life upon ingestion of synbiotics early in life.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: May 2, 2023
    Assignee: N.V. Nutricia
    Inventors: Eefje Engels, Cornelus Johannes Petrus Van Limpt, Annemarie Oosting, Akhtar Raish Oozeer, Jan Knol, Mona Mischke
  • Patent number: 11617771
    Abstract: The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophiles, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: April 4, 2023
    Assignee: The Regents of the University of California
    Inventor: Anahid Jewett
  • Patent number: 11607435
    Abstract: This invention relates to novel probiotic Bifidobacteria strains, particularly, B. pseudocatenulatum strains, and their use as probiotic, and food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of obesity, diabetes, and related conditions.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: March 21, 2023
    Assignee: PERFECT (CHINA) CO., LTD.
    Inventors: Liping Zhao, Guojun Wu, Menghui Zhang, Chenhong Zhang, Huan Wu
  • Patent number: 11576884
    Abstract: The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: February 14, 2023
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., ENTRINSIC, LLC
    Inventors: Sadasivan Vidyasagar, Reshu Gupta, Liangjie Yin, Astrid Grosche, Paul Gerson Okunieff, Stephen Gatto, Daniel Dennison
  • Patent number: 11571387
    Abstract: The invention relates to a process for the preparation of dry lyophilized powdered formulations of probiotic bacteria for monogastric animal (for example poultry birds) using a combination of different polymers through the process of encapsulation. The resulting lyophilized powders of probiotic bacteria are having increased viability during animal feed processing, storage and upon transfer to the monogastric animal's digestive system.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 7, 2023
    Assignee: PRAJ INDUSTRIES LIMITED
    Inventors: Aamod Anil Natu, Sharad Krishnachandra Laldas, Shaileshkumar Dhondiram Sawale, Shilpa Sachin Pradhan, Aarohi Atul Kulkarni
  • Patent number: 11564908
    Abstract: Provided is a long-acting method for preventing or treating glucose metabolism disorders that includes administering a beta-lactam compound or a pharmaceutically acceptable salt thereof to a subject in need thereof. The method for preventing or treating glucose metabolism disorders has a long-acting effect that lasts more than two days even after medication has been stopped.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: January 31, 2023
    Assignee: GLYCOLYSIS BIOMED CO., LTD.
    Inventors: Feng-Ling Lee, Lung-Jr Lin, Jyh-Shing Hsu, Cheng-Hsien Hsu, Yen-Chun Huang, Ya-Chien Huang, Chun-Tsung Lo, Hui-Fang Liao, Yu-Wen Liu, Yu-Chi Kao
  • Patent number: 11541031
    Abstract: The present invention relates to a composition comprising at least one cocoa polyphenol and soluble dietary fiber for use in the prevention or treatment of a disorder associated with an above-normal number of granulocytes in a tissue.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: January 3, 2023
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Carine Blanchard, Sebastien Holvoet, Rinat Ran-Ressler, Martinas Kuslys
  • Patent number: 11541069
    Abstract: The invention relates to a human milk oligosaccharide (HMO) for use in reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity in a human. The invention also relates to a synthetic composition for use, comprising one or more of said HMOs. The invention further relates to a method for reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity by administering at least one HMO and the use of said one or more HMOs in a dietary management of a human.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: January 3, 2023
    Assignee: Glycom A/S
    Inventors: Bruce McConnell, Louise Kristine Vigsnæs, Ingvild Dybdrodt Amundsen
  • Patent number: 11541083
    Abstract: In some aspects, methods and probiotic compositions are provided for the treatment of bone diseases such as, e.g., ostetoporosis. In some embodiments, one or more bacteria from the warm microbiota such as, e.g., Clostridialeace-assimilate, Lactobacillus, Bifidobacteriaceae, Akkermansia, and/or Parabacteroides may be administered to a subject, such as a human subject, to treat the bone disease. In some embodiments, heat may be applied to the subject to promote the development of warm microbiota to treat the bone disease.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: January 3, 2023
    Assignee: Research Development Foundation
    Inventors: Mirko Trajkovski, Claire Chevalier
  • Patent number: 11533933
    Abstract: This invention relates to the development of products that are alternatives to antibiotics with medically important human therapeutic uses for livestock meat and protein production efficiency. These products will be used to replace antibiotics used to rapidly increase lean muscle mass with specific feed regimens. The present invention is for the identification of non-human antibiotic products to be used with different feed regimens for livestock growth and meat promotion that include prebiotic supplements and keystone species probiotics that produce the desired growth promotion phenotypic effects. The present invention includes the identification of enterotypes that can be used as targets for recapitulation by compounds that are screened to produce the desired phenotype.
    Type: Grant
    Filed: August 20, 2017
    Date of Patent: December 27, 2022
    Inventor: John Malcolm Hall Gregg
  • Patent number: 11528928
    Abstract: This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3?-Siallylactose (3?-SL) and 6?-Siallylactose (6?-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: December 20, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Zhizhong Dong, Yujie Shi, Bing Wang
  • Patent number: 11517582
    Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: December 6, 2022
    Assignee: SNIPR TECHNOLOGIES LIMITED
    Inventors: Jasper Clube, Morten Sommer, Christian Grøndahl, Eric Van Der Helm, Ruben Vanquez-Uribe
  • Patent number: 11505510
    Abstract: A biological inoculant having both fertilizing and fungicidal activity is disclosed. More particularly, a bio-inoculant having the said combined effects, comprising Bradyrhizobium japonicum and specific isolates from the Trichoderma genus is disclosed. The bio-inoculant is applied to soybean crops for preventing fungi borne diseases. More particularly, the bio-inoculant of the invention is useful for protecting soybean crops against infection by Fusarium sp., Colletotrichum sp., Cercospora sp., Sclerotinia sp. and Rhizoctonia sp.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 22, 2022
    Assignee: YPF TECNOLOGIA S.A.
    Inventors: Walter Alberto Vargas, Sebastián Reinoso, María Cecilia Orsini, Sebastián Alejandro Trejo, Eliana Abrahamovich
  • Patent number: 11504387
    Abstract: A composition contains at least one probiotic or enzyme selected from the group consisting of (i) a probiotic having ?-glycosidase activity or a ?-glycosidase, (ii) a probiotic having esterase activity or an esterase, (iii) a probiotic having both ?-glycosidase activity and esterase activity or an enzyme having both ?-glycosidase activity and esterase activity, (iv) a first probiotic having ?-glycosidase activity and a second probiotic having esterase activity, (v) a probiotic having ?-glycosidase activity and an esterase, (vi) a ?-glycosidase and a probiotic having esterase activity and (vii) a ?-glycosidase and an esterase. The at least one probiotic can form one or more of oleuropein aglycone, elenolic acid, hydroxytyrosol acetate or hydroxytyrosol from oleuropein. The composition can comprise oleuropein.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 22, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Marie Noelle Horcajada, Stephane Duboux, Laure Poquet
  • Patent number: 11478525
    Abstract: Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: October 25, 2022
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
  • Patent number: 11479749
    Abstract: The subject invention provides standardized, high concentration inocula in solid form for use as seed cultures in scaled-up cultivation. Further embodiments include methods of producing standardized inocula, as well as methods of preserving and storing the inocula for convenient use over extended periods of time.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: October 25, 2022
    Assignee: LOCUS IP COMPANY, LLC
    Inventors: Ken Alibek, Sean Farmer, Alibek Moldakozhayev
  • Patent number: 11472981
    Abstract: The present disclosure provides stable inoculant compositions and methods for enhancing the survival and/or stability of microorganisms in an inoculant composition. In some embodiments, the microorganisms in an inoculant compositions are stabilized by the presence of one or more maltodextrins having a dextrose equivalent value of about 15 to about 20.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: October 18, 2022
    Assignee: NOVOZYMES BIOAG A/S
    Inventors: Kenneth Edmund Kellar, Yaowei Kang, Claire Pelligra, Emily Barnett, Caitlin Burklew, Anna Wysinski, Jarrod E. Leland, Ben Doughan, Michael Harrison Fethe, Ashley Delanie Trahan, David Greenshields, Kristi Woods
  • Patent number: 11452746
    Abstract: The disclosure is concerned with a novel human intestinal isolate capable of converting L-lysine into butyrate and/or of converting fructose-lysine into butyrate. The novel isolate can be used as a probiotic or supplement to promote production of butyrate in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of butyrate. Additionally, the isolate may prevent and/or treat conditions or diseases caused by an excess of pathogenic bacteria in the GI tract, mediated by L-lysine, or mediated by fructose-lysine or other advanced glycation end products.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: September 27, 2022
    Assignee: WAGENINGEN UNIVERSITEIT
    Inventors: Willem Meindert De Vos, Thi Phuong Nam Bui
  • Patent number: 11426436
    Abstract: Described is a novel human intestinal isolate capable of converting L-lysine into butyrate and/or of converting fructose-lysine into butyrate. The novel isolate can be used as a probiotic or supplement to promote production of butyrate in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of butyrate. Additionally, the isolate may prevent and/or treat conditions or diseases caused by an excess of pathogenic bacteria in the GI tract, mediated by L-lysine, or mediated by fructose-lysine or other advanced glycation end products.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: August 30, 2022
    Assignee: Wageningen Universiteit
    Inventors: Willem Meindert De Vos, Thi Phuong Nam Bui
  • Patent number: 11406671
    Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: August 9, 2022
    Assignee: The Translational Genomics Research Institute
    Inventors: Cindy Liu, Lance B. Price
  • Patent number: 11401499
    Abstract: The present invention relates to a method for providing a fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism, the method comprises the step of: (i) providing a main growth solution; (ii) optionally sterilizing the main growth solution provided in step (i); (iii) providing a trace metal solution; and (iv) mixing the main growth solution (as provided in step (i) or (ii)) with the trace metal solution provided in step (iii) and providing the fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: August 2, 2022
    Assignee: UNIBIO A/S
    Inventors: Subir Kumar Nandy, Ib Christensen, Budi Juliman Hidayat
  • Patent number: 11382936
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing autoimmune and inflammatory disorders of the central nervous system.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: July 12, 2022
    Assignee: 4D Pharma Research Limited
    Inventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson
  • Patent number: 11351205
    Abstract: The present invention generally relates to therapeutic compositions and methods for treating cancer patients. The compositions and methods can increase efficacy of an anti-cancer therapy, or treat, prevent, or inhibit an oncology-treatment induced condition (OTIC) induced by an anti-cancer therapy. The therapeutic compositions comprise microbial compositions and, optionally, an anti-cancer therapeutic agent. The methods comprise administering a therapeutic composition comprising a microbial composition and administering an anti-cancer therapy.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: June 7, 2022
    Assignee: Finch Therapeutics Holdings LLC
    Inventors: Joseph Lobacki, Ulrich Thienel, Zain Kassam, Marina Santiago
  • Patent number: 11318179
    Abstract: A topical cream or ointment is provided that provides for the binding to CB1 and/or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: May 3, 2022
    Inventor: Jessica Kado
  • Patent number: 11311631
    Abstract: Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative having reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: April 26, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 11291697
    Abstract: The present disclosure relates to the field of microbial technology, and discloses a probiotic composition and use thereof. The probiotic composition in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631 and Lactobacillus rhamnosus CCFM1044, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering epididymal fat content, lowering fasting blood glucose level, lowering the area under sugar tolerance curve and lowering contents of serum low density lipoprotein and total cholesterol, improving liver antioxidant capacity and lowering serum IL-1? content, etc. The extent of decrease or increase is increased by 9.62% to 769.62% compared with formulations of a single probiotic or a combination of two probiotics. The combination of three probiotics achieves a significant synergistic effect.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: April 5, 2022
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan Wang, Wei Chen, Gang Wang, Xiaofeng Zhu, Fangli Ma, Junyong Xiao, Hao Zhang, Jianxin Zhao
  • Patent number: 11291677
    Abstract: The invention relates to a composition comprising one or more human milk oligosaccharides (HMOs) for use in stimulating the production of butyrate in the gastro-intestinal tract of a non-infant human and obtaining delayed increase in the level of butyrate in the gastro-intestinal tract of the non-infant human, and methods for their use.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: April 5, 2022
    Assignee: Glycom A/S
    Inventors: Louise Kristine Vigsnæs, Bruce McConnell
  • Patent number: 11266700
    Abstract: Provided herein are methods and compositions related to immune modulating Lactococcus strains useful as therapeutic agents. In certain embodiments, provided herein are methods of treating an immune disorder in a subject comprising administering to the subject a bacterial composition comprising Lactococcus lactis cremoris Strain A (ATCC Deposit Number PTA-125368).
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: March 8, 2022
    Assignee: Evelo Biosciences, Inc.
    Inventors: Brian Goodman, Holly Ponichtera, Andrea Itano, Mark Bodmer, Taylor A. Cormack, Maria Sizova, Carolina Baez-Giangreco, Duncan McHale, Kritika Ramani
  • Patent number: 11224605
    Abstract: The application relates to synthetic compositions containing one or more human milk oligosaccharides for treating serotonin and/or tryptophan dysregulation.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: January 18, 2022
    Assignee: Glycom A/S
    Inventors: Louise Kristine Vigsnæs, Bruce McConnell, Emma Elison
  • Patent number: 11224620
    Abstract: The invention provides compositions comprising one or more bacterial strains for treating or preventing visceral hypersensitivity.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: January 18, 2022
    Assignee: 4D PHARMA PLC
    Inventors: Annick Bernalier-Donadille, Laureen Crouzet, Chloe Habouzit
  • Patent number: 11219674
    Abstract: The present invention relates to vaccine(s) comprising cancer cells expressing antigen(s), excipients, optionally adjuvant wherein the said antigen(s) is expressed on contacting the said cancer cell with p38 inducer, for use in treatment of Cancer. The vaccine composition induces specific immune response against homologous and heterologus cancer cells of the tissue/organ. The invention also provides method of preparing the same.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 11, 2022
    Assignee: Cadila Pharmaceuticals Ltd.
    Inventors: Bakulesh Mafatlal Khamar, Nirav Manojkumar Desai, Chandreshwar Prasad Shukla, Avani Devenbhai Darji, Indravadan Ambalal Modi
  • Patent number: 11213549
    Abstract: The present disclosure is in the field of pharmaceutical compositions suitable for the treatment of diseases in mammals. The disclosure provides novel compositions comprising non-pathogenic fecal microbes for treating primary sclerosing cholangitis and related diseases. The disclosure also provides methods for treating a subject with the compositions disclosed herein.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: January 4, 2022
    Assignee: Finch Therapeutics Holdings LLC
    Inventor: Thomas Julius Borody
  • Patent number: 11179405
    Abstract: The present invention relates to nutritional compositions for infants or young children and their health effects, that comprise at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide. These nutritional compositions are for use to prevent and/or treat infection in an infant or young child, by promoting and/or reducing specific microbiota communities in an infant or young child.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: November 23, 2021
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Bernard Berger, Norbert Sprenger, Dominik Grathwohl
  • Patent number: 11166457
    Abstract: An environmentally responsive Paecilomyces lilacinus microbead and its preparation method and application are provided. The Paecilomyces lilacinus microbead includes a capsule core and a capsule wall; wherein, in the capsule core, Paecilomyces lilacinus spore powder, a vegetable oil, glucose, peptone, a cellulose nanofiber, sodium citrate, and a surfactant are combined to form an emulsifiable capsule core; and in the capsule wall, chitosan, gelatin, polyvinyl alcohol, glycerol, and water are combined to form a water-responsive shell. The environmentally responsive Paecilomyces lilacinus microbeads can stimulate the dissolution of polyvinyl alcohol in the shell according to the moisture content in the soil, so that the water in the soil flows into the microbeads. The cellulose nanofibers in the microbeads absorb water and expand, blocking the holes in the shell, resulting in the inability of spores to flow out.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: November 9, 2021
    Assignee: Jiangxi Huawei Technology Co., Ltd.
    Inventors: Liqiang Zou, Tong Wu, Guizhong Chen, Wei Liu
  • Patent number: 11160762
    Abstract: The present invention relates to a modified release coated capsule and a process to obtain that capsule.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 2, 2021
    Assignee: Tillotts Pharma AG
    Inventors: Roberto Carlos Bravo Gonzaléz, Felipe José Oliveira Varum, Thomas Buser