Bacteria Or Actinomycetales Patents (Class 424/93.4)
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Patent number: 12102710Abstract: Described herein are dermatological compositions, formulations containing wild type or genetically modified Cutibacterium bacteria and methods for use thereof of skin. The cosmetic and therapeutic formulations described herein can be used as cosmetic daily skin treatments or for treating skin inflammation or disorders including acne, psoriasis, rosacea, dermatitis, or eczema.Type: GrantFiled: June 22, 2021Date of Patent: October 1, 2024Assignee: CROWN LABORATORIES, INC.Inventors: Thomas M. Hitchcock, Sasima Phadungpojna, Matthew D. Stephens, Mun Su Rhee
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Patent number: 12064459Abstract: Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.Type: GrantFiled: April 28, 2021Date of Patent: August 20, 2024Assignee: DermBiont, Inc.Inventors: Robert M. Brucker, Xuecheng Zhang, Ida Lister, Sanjay Jain
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Patent number: 12059442Abstract: Provided are means, methods, and compositions effective for obesity treatment using probiotics such as bifidobacteria or lactobacilli. Also, a method of selecting probiotic bacteria having a body fat reducing effect, and a method of selecting responders to probiotic bacteria having an anti-obesity action are provided. Provided is a composition for reducing body fat, or the like, which contains Bifidobacterium and/or lactobacilli as an active ingredient, and is used for a pre-obesity group or an obesity disease including intestinal flora in which the ratio of the phylum Firmicutes to the phylum Bacteroidetes has a high value.Type: GrantFiled: March 27, 2019Date of Patent: August 13, 2024Assignee: MORINAGA MILK INDUSTRY CO., LTD.Inventors: Junichi Minami, Akira Sen
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Patent number: 12042520Abstract: The invention relates to the pharmaceutical or non-pharmaceutical use of an effective amount of spirulina and/or of an extract/extracts of spirulina for improving the bioavailability of orally administered curcumin in humans or animals. The invention also includes pharmaceutical or non-pharmaceutical preparations including spirulina and/or extracts of spirulina containing curcumin having improved bioavailability.Type: GrantFiled: June 30, 2015Date of Patent: July 23, 2024Inventor: Antonello Fresu
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Patent number: 12022851Abstract: The present invention provides anti-bacterial compositions comprising whole cells of an Aneurinibacillus bacterium designated as NH or an anti-bacterial protein expressed by NH. Additionally, the present invention provides methods of using the anti-bacterial compositions to inhibit the growth of bacteria such as Campylobacter jejuni and Listeria monocytogenes.Type: GrantFiled: August 31, 2022Date of Patent: July 2, 2024Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventor: Peter M. Rubinelli
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Patent number: 12004545Abstract: The present invention relates to a complementary nutritional composition characterized by a low glycemic load and/or index and/or comprising an ingredient characterized by a low glycemic index for use in treatment, prevention and/or reducing the risk of a metabolic syndrome disorder appearing later in life.Type: GrantFiled: June 27, 2022Date of Patent: June 11, 2024Assignee: Societe des Produits Nestle S.A.Inventors: Kevin John Acheson, Catherine Mace, Yassaman Shahkhalili Dulloo
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Patent number: 12004528Abstract: The present disclosure relates to human milk compositions and methods of making and using the same. In particular, the disclosure features methods of using human milk compositions to feed subjects before and/or after surgery or medical operations and that are useful in promoting recovery.Type: GrantFiled: December 22, 2021Date of Patent: June 11, 2024Assignee: PROLACTA BIOSCIENCE, INC.Inventors: Scott Elster, Joseph Fournell
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Patent number: 11992015Abstract: The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacterium sp_Panamam (Csp_P).Type: GrantFiled: July 29, 2021Date of Patent: May 28, 2024Assignee: The Johns Hopkins UniversityInventors: George Dimopoulos, Sarah M. Short, Jose L. Ramirez
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Patent number: 11965004Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.Type: GrantFiled: July 10, 2018Date of Patent: April 23, 2024Assignee: SRI InternationalInventors: Kathlynn C. Brown, Nathan Collins, Shunzi “Susan” Li, Curtis Allred, Keen Chung, Michael McGuire
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Patent number: 11912788Abstract: Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of non-enteric infections in a subject. Also provided are compositions of the peptides formulated as or within food products, beverages, nutritional supplements, medicaments and the like.Type: GrantFiled: March 16, 2018Date of Patent: February 27, 2024Assignee: MICROSINTESIS INC.Inventors: Monica Angela Cella, Sarah M. Curtis, Jonathon Patrick Roepke
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Patent number: 11884952Abstract: The present invention provides a novel daptomycin-producing Streptomyces strain and use thereof, the strain is a subspecies of streptomyces griseus, named Streptomyces griseus L340, and the preservation number is CGMCC17921. The genetic character and fermentation unit of the strain provided by the present invention are relatively stable, the culture and fermentation conditions are suitable for industrial production of daptomycin, and the interference of pigment in later separation and purification is eliminated. The secondary metabolite daptomycin is obtained through fermentation of the Streptomyces provided by the present invention, which has the advantages of no interference of pigment accumulation, cleaner metabolic spectrum and thus is obviously superior in later separation and purification.Type: GrantFiled: April 21, 2020Date of Patent: January 30, 2024Assignee: ZHEJIANG UNIVERSITYInventors: Yongquan Li, Jiaole Fang, Xuming Mao, Xinai Chen
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Patent number: 11865145Abstract: The present invention relates to, in part, compositions and methods for delivery of novel mixtures of bacterial strains for maintaining and/or restoring a healthy gut barrier.Type: GrantFiled: August 7, 2018Date of Patent: January 9, 2024Assignee: Finch Therapeutics Holdings LLCInventors: Marina Santiago, Kevin Roelofs
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Patent number: 11845948Abstract: Disclosed herein are the nucleotide sequences of the Chromobacterium subtsugae genes. In addition, the amino acid sequences of proteins encoded by the C. subtsugae genes are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, functional fragments and conservative variants of the aforementioned sequences are also provided. Compositions having pesticidal, bioremedial and plant growth-promoting activities comprising C. subtsugae genes and proteins, and methods for the use of these compositions, are also provided.Type: GrantFiled: August 23, 2021Date of Patent: December 19, 2023Assignee: Pro Farm Group, Inc.Inventors: Ana Lucia Cordova-Kreylos, Scott Burman, Debora Wilk
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Patent number: 11844816Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.Type: GrantFiled: July 20, 2022Date of Patent: December 19, 2023Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on behalf of Northern Arizona UniversityInventors: Cindy Liu, Lance B. Price
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Fowl production by administration of a synthetic bioensemble of microbes or purified strains thereof
Patent number: 11825862Abstract: The disclosure relates to isolated microorganisms-including novel strains of the microorganisms-microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial ensembles, and compositions comprising the same, in methods for modulating the production of poultry, disease resistance, and egg yield. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of preventing colonization of pathogenic microbes.Type: GrantFiled: October 18, 2018Date of Patent: November 28, 2023Assignee: Native Microbials, Inc.Inventors: Mallory Embree, Grant Gogul, Cameron Martino, Norm Pitt -
Patent number: 11760971Abstract: Methods for improving the ability of a population of biological agents to compete and survive in a field setting are provided. The modified population of agents is able to grow, compete with other microbial strains and fungi, and provide protection for plants from pathogens. Modified biological agents and modified populations of such agents that are herbicide tolerant or resistant are selected or engineered. In this manner, the protection from disease-causing agents is enhanced. Such modified populations can be added to soils to prevent fungal pathogens and associated diseases, promoting plant growth. The present invention is useful for enhancing the competitiveness of modified biological agents particularly over other microbial agents which are not herbicide resistant. Compositions include selected or engineered herbicide resistant biological agents and modified populations of biocontrol agents. These modified biological agents can be used as an inoculant or as a seed coating for plants and seeds.Type: GrantFiled: March 19, 2021Date of Patent: September 19, 2023Assignee: AgBiome, Inc.Inventors: Philip E. Hammer, Janice C. Jones, Michael G. Koziel, Scott Joseph Uknes
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Patent number: 11758924Abstract: The subject invention provides compositions and methods for reducing deleterious atmospheric gases and/or precursors thereof using livestock feed additives and/or supplements. In preferred embodiments, a multi-purpose composition comprising one or more beneficial microorganisms and/or one or more microbial growth by-products is applied to livestock animals' feed and/or to a field or pasture where livestock animals graze. In some embodiments, the composition controls methanogenic bacteria. In some embodiments, the composition enhances carbon sequestration in the field or pasture by promoting plant health and/or growth.Type: GrantFiled: March 30, 2020Date of Patent: September 19, 2023Assignee: LOCUS SOLUTIONS IPCO, LLCInventors: Sean Farmer, Ken Alibek
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Patent number: 11752179Abstract: The present invention relates to the use of a composition based on bacteria and/or yeasts and/or other microorganisms, taken singularly or in combination, for the treatment of abdominal pain by administering to a patient suffering from Irritable Bowel Syndrome (IBS). In particular, the bacteria comprise Lactobacillus paracasei DG strain deposited with the deposit number CNCMI 1572.Type: GrantFiled: June 8, 2017Date of Patent: September 12, 2023Assignee: ALFASIGMA S.P.A.Inventors: Andrea Biffi, Walter Fiore, Ruggero Rossi
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Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
Patent number: 11744867Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.Type: GrantFiled: July 23, 2021Date of Patent: September 5, 2023Assignees: California Institute of Technology, The Regents of the University of CaliforniaInventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson -
Patent number: 11737466Abstract: The present invention provides a method of improving the ability of plants to resistance diseases, comprising using a strain of Bacillus amyloliquefaciens and a Bidens plant extract; and the Bidens plant extract enhances the ability of the Bacillus amyloliquefaciens to inhibit the growth of the Acidovorax avenae subsp. citrulli, increases the metabolic activity of the Bacillus amyloliquefaciens, increases the amount of the biofilm formation of the Bacillus amyloliquefaciens, and maintains the alive number of the Bacillus amyloliquefaciens.Type: GrantFiled: December 10, 2019Date of Patent: August 29, 2023Assignees: NATIONAL TAIWAN UNIVERSITY, ACADEMIA SINICAInventors: Chi-Te Liu, Wen-Chin Yang, Yen-Yu Liu, Chu-Ning Huang, Chan-Pin Lin
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Patent number: 11730971Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.Type: GrantFiled: July 28, 2020Date of Patent: August 22, 2023Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Jon P. Dobson, Josephine Allen
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Patent number: 11730775Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.Type: GrantFiled: April 5, 2021Date of Patent: August 22, 2023Assignee: Seres Therapeutics, Inc.Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey Von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
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Patent number: 11702454Abstract: The present invention belongs to the field of biotechnology, in particular to a multivalent fusion protein AB-NAC-189, method for producing the same, and uses thereof. The protein AB-NAC-189 is a fusion of a polypeptide segment AB, nascent polypeptide-associated complex (NAC), and a protein 189 corresponding to amino acids 1-189 from the N-terminal of protein HarpinEa. The fusion has the properties of a multivalent plant immune protein, thus it can effectively stimulate the hypersensitive response of tobacco leaves and has good thermal stability. While stimulating the immune response of plants, it can also improve the disease resistance of plants and promote plant growth. The AB-NAC-189 multivalent vaccine shows higher activity per unit concentration, and greater ability to promote growth of wheat and tobacco; meanwhile it can significantly promote chlorophyll synthesis in Goji berry, thereby improving the yield and quality of Goji berries.Type: GrantFiled: October 17, 2021Date of Patent: July 18, 2023Assignee: Suzhou Yishuimo Biological Technology Co., LTDInventors: Aiyou Sun, Zhong Wang, Zengying Cai, Qun Yu, Zhiwei Li, Bing Sun, Chong Zhang, Shiyue Miao
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Patent number: 11696921Abstract: A human milk oligosaccharide (HMO) or a synthetic composition comprising said HMO, for use in increasing the abundance, particularly the relative abundance, of a Bifidobacterium of the B. adolescentis phylogenic group in the microbiota in the gastro-intestinal tract of a human, preferably a non-infant human. The HMO(s) and/or synthetic composition is useful in; increasing particularly the relative abundance of B. adolescentis and/or B. pseudocatenulatum; for treating or preventing in said non-infant human with type 2 diabetes and/or obesity; an enteropathogenic infection; impaired gut barrier function and/or; an inflammation related to gastro¬intestinal condition, preferably irritable bowel disease (IBD) or irritable bowel syndrome (IBS); as a nutritional composition. The HMO is a fucosylated neutral HMO, a non-fucosylated neutral HMO, or a mixture of a fucosylated and a non-fucosylated neutral HMO.Type: GrantFiled: August 24, 2020Date of Patent: July 11, 2023Assignee: GLYCOM A/SInventors: Louise Kristine Vigsnæs, Bruce McConnell
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Patent number: 11684633Abstract: A method is provided for preventing and/or treating heart failure in a subject in need thereof by administering to the subject a therapeutically effective amount of polydextrose. The method may also include the use of polydextrose for preventing cardiac remodeling and/or ventricle dilatation and/or for preventing systolic dysfunction, as well as preventing an increase in bacterial translocation to heart tissue in a subject who suffered from a myocardial infarction.Type: GrantFiled: January 5, 2021Date of Patent: June 27, 2023Assignees: VAIOMER, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Christophe Heymes, Rémy Burcelin, Benjamin Lelouvier, Jacques Amar
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Patent number: 11638729Abstract: The invention relates to prevention of insulin resistance or low-grade chronic inflammation later in life upon ingestion of synbiotics early in life.Type: GrantFiled: December 30, 2019Date of Patent: May 2, 2023Assignee: N.V. NutriciaInventors: Eefje Engels, Cornelus Johannes Petrus Van Limpt, Annemarie Oosting, Akhtar Raish Oozeer, Jan Knol, Mona Mischke
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Patent number: 11617771Abstract: The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophiles, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.Type: GrantFiled: December 15, 2017Date of Patent: April 4, 2023Assignee: The Regents of the University of CaliforniaInventor: Anahid Jewett
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Patent number: 11607435Abstract: This invention relates to novel probiotic Bifidobacteria strains, particularly, B. pseudocatenulatum strains, and their use as probiotic, and food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of obesity, diabetes, and related conditions.Type: GrantFiled: February 10, 2017Date of Patent: March 21, 2023Assignee: PERFECT (CHINA) CO., LTD.Inventors: Liping Zhao, Guojun Wu, Menghui Zhang, Chenhong Zhang, Huan Wu
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Patent number: 11576884Abstract: The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit.Type: GrantFiled: October 4, 2017Date of Patent: February 14, 2023Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., ENTRINSIC, LLCInventors: Sadasivan Vidyasagar, Reshu Gupta, Liangjie Yin, Astrid Grosche, Paul Gerson Okunieff, Stephen Gatto, Daniel Dennison
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Patent number: 11571387Abstract: The invention relates to a process for the preparation of dry lyophilized powdered formulations of probiotic bacteria for monogastric animal (for example poultry birds) using a combination of different polymers through the process of encapsulation. The resulting lyophilized powders of probiotic bacteria are having increased viability during animal feed processing, storage and upon transfer to the monogastric animal's digestive system.Type: GrantFiled: March 5, 2018Date of Patent: February 7, 2023Assignee: PRAJ INDUSTRIES LIMITEDInventors: Aamod Anil Natu, Sharad Krishnachandra Laldas, Shaileshkumar Dhondiram Sawale, Shilpa Sachin Pradhan, Aarohi Atul Kulkarni
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Patent number: 11564908Abstract: Provided is a long-acting method for preventing or treating glucose metabolism disorders that includes administering a beta-lactam compound or a pharmaceutically acceptable salt thereof to a subject in need thereof. The method for preventing or treating glucose metabolism disorders has a long-acting effect that lasts more than two days even after medication has been stopped.Type: GrantFiled: January 21, 2020Date of Patent: January 31, 2023Assignee: GLYCOLYSIS BIOMED CO., LTD.Inventors: Feng-Ling Lee, Lung-Jr Lin, Jyh-Shing Hsu, Cheng-Hsien Hsu, Yen-Chun Huang, Ya-Chien Huang, Chun-Tsung Lo, Hui-Fang Liao, Yu-Wen Liu, Yu-Chi Kao
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Patent number: 11541031Abstract: The present invention relates to a composition comprising at least one cocoa polyphenol and soluble dietary fiber for use in the prevention or treatment of a disorder associated with an above-normal number of granulocytes in a tissue.Type: GrantFiled: December 1, 2016Date of Patent: January 3, 2023Assignee: Societe des Produits Nestle S.A.Inventors: Carine Blanchard, Sebastien Holvoet, Rinat Ran-Ressler, Martinas Kuslys
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Patent number: 11541083Abstract: In some aspects, methods and probiotic compositions are provided for the treatment of bone diseases such as, e.g., ostetoporosis. In some embodiments, one or more bacteria from the warm microbiota such as, e.g., Clostridialeace-assimilate, Lactobacillus, Bifidobacteriaceae, Akkermansia, and/or Parabacteroides may be administered to a subject, such as a human subject, to treat the bone disease. In some embodiments, heat may be applied to the subject to promote the development of warm microbiota to treat the bone disease.Type: GrantFiled: September 27, 2019Date of Patent: January 3, 2023Assignee: Research Development FoundationInventors: Mirko Trajkovski, Claire Chevalier
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Patent number: 11541069Abstract: The invention relates to a human milk oligosaccharide (HMO) for use in reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity in a human. The invention also relates to a synthetic composition for use, comprising one or more of said HMOs. The invention further relates to a method for reducing or preventing fatigue and/or improving focus or concentration on a mental or physical activity by administering at least one HMO and the use of said one or more HMOs in a dietary management of a human.Type: GrantFiled: November 2, 2018Date of Patent: January 3, 2023Assignee: Glycom A/SInventors: Bruce McConnell, Louise Kristine Vigsnæs, Ingvild Dybdrodt Amundsen
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Patent number: 11533933Abstract: This invention relates to the development of products that are alternatives to antibiotics with medically important human therapeutic uses for livestock meat and protein production efficiency. These products will be used to replace antibiotics used to rapidly increase lean muscle mass with specific feed regimens. The present invention is for the identification of non-human antibiotic products to be used with different feed regimens for livestock growth and meat promotion that include prebiotic supplements and keystone species probiotics that produce the desired growth promotion phenotypic effects. The present invention includes the identification of enterotypes that can be used as targets for recapitulation by compounds that are screened to produce the desired phenotype.Type: GrantFiled: August 20, 2017Date of Patent: December 27, 2022Inventor: John Malcolm Hall Gregg
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Patent number: 11528928Abstract: This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3?-Siallylactose (3?-SL) and 6?-Siallylactose (6?-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.Type: GrantFiled: March 17, 2016Date of Patent: December 20, 2022Assignee: Societe des Produits Nestle S.A.Inventors: Zhizhong Dong, Yujie Shi, Bing Wang
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Patent number: 11517582Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: GrantFiled: April 4, 2017Date of Patent: December 6, 2022Assignee: SNIPR TECHNOLOGIES LIMITEDInventors: Jasper Clube, Morten Sommer, Christian Grøndahl, Eric Van Der Helm, Ruben Vanquez-Uribe
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Patent number: 11504387Abstract: A composition contains at least one probiotic or enzyme selected from the group consisting of (i) a probiotic having ?-glycosidase activity or a ?-glycosidase, (ii) a probiotic having esterase activity or an esterase, (iii) a probiotic having both ?-glycosidase activity and esterase activity or an enzyme having both ?-glycosidase activity and esterase activity, (iv) a first probiotic having ?-glycosidase activity and a second probiotic having esterase activity, (v) a probiotic having ?-glycosidase activity and an esterase, (vi) a ?-glycosidase and a probiotic having esterase activity and (vii) a ?-glycosidase and an esterase. The at least one probiotic can form one or more of oleuropein aglycone, elenolic acid, hydroxytyrosol acetate or hydroxytyrosol from oleuropein. The composition can comprise oleuropein.Type: GrantFiled: November 8, 2018Date of Patent: November 22, 2022Assignee: Societe des Produits Nestle S.A.Inventors: Marie Noelle Horcajada, Stephane Duboux, Laure Poquet
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Patent number: 11505510Abstract: A biological inoculant having both fertilizing and fungicidal activity is disclosed. More particularly, a bio-inoculant having the said combined effects, comprising Bradyrhizobium japonicum and specific isolates from the Trichoderma genus is disclosed. The bio-inoculant is applied to soybean crops for preventing fungi borne diseases. More particularly, the bio-inoculant of the invention is useful for protecting soybean crops against infection by Fusarium sp., Colletotrichum sp., Cercospora sp., Sclerotinia sp. and Rhizoctonia sp.Type: GrantFiled: August 7, 2019Date of Patent: November 22, 2022Assignee: YPF TECNOLOGIA S.A.Inventors: Walter Alberto Vargas, Sebastián Reinoso, María Cecilia Orsini, Sebastián Alejandro Trejo, Eliana Abrahamovich
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Patent number: 11479749Abstract: The subject invention provides standardized, high concentration inocula in solid form for use as seed cultures in scaled-up cultivation. Further embodiments include methods of producing standardized inocula, as well as methods of preserving and storing the inocula for convenient use over extended periods of time.Type: GrantFiled: August 22, 2019Date of Patent: October 25, 2022Assignee: LOCUS IP COMPANY, LLCInventors: Ken Alibek, Sean Farmer, Alibek Moldakozhayev
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Patent number: 11478525Abstract: Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.Type: GrantFiled: December 26, 2019Date of Patent: October 25, 2022Assignee: TCI CO., LTD.Inventors: Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
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Patent number: 11472981Abstract: The present disclosure provides stable inoculant compositions and methods for enhancing the survival and/or stability of microorganisms in an inoculant composition. In some embodiments, the microorganisms in an inoculant compositions are stabilized by the presence of one or more maltodextrins having a dextrose equivalent value of about 15 to about 20.Type: GrantFiled: September 7, 2016Date of Patent: October 18, 2022Assignee: NOVOZYMES BIOAG A/SInventors: Kenneth Edmund Kellar, Yaowei Kang, Claire Pelligra, Emily Barnett, Caitlin Burklew, Anna Wysinski, Jarrod E. Leland, Ben Doughan, Michael Harrison Fethe, Ashley Delanie Trahan, David Greenshields, Kristi Woods
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Patent number: 11452746Abstract: The disclosure is concerned with a novel human intestinal isolate capable of converting L-lysine into butyrate and/or of converting fructose-lysine into butyrate. The novel isolate can be used as a probiotic or supplement to promote production of butyrate in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of butyrate. Additionally, the isolate may prevent and/or treat conditions or diseases caused by an excess of pathogenic bacteria in the GI tract, mediated by L-lysine, or mediated by fructose-lysine or other advanced glycation end products.Type: GrantFiled: January 8, 2016Date of Patent: September 27, 2022Assignee: WAGENINGEN UNIVERSITEITInventors: Willem Meindert De Vos, Thi Phuong Nam Bui
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Patent number: 11426436Abstract: Described is a novel human intestinal isolate capable of converting L-lysine into butyrate and/or of converting fructose-lysine into butyrate. The novel isolate can be used as a probiotic or supplement to promote production of butyrate in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of butyrate. Additionally, the isolate may prevent and/or treat conditions or diseases caused by an excess of pathogenic bacteria in the GI tract, mediated by L-lysine, or mediated by fructose-lysine or other advanced glycation end products.Type: GrantFiled: September 23, 2020Date of Patent: August 30, 2022Assignee: Wageningen UniversiteitInventors: Willem Meindert De Vos, Thi Phuong Nam Bui
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Patent number: 11406671Abstract: Embodiments of the invention provide a method of reducing colonization of a subject's anterior nares and/or nasal cavity by a microorganism (e.g., Staphylococcus aureus). In some aspects, the method may include administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of at least one probiotic.Type: GrantFiled: April 25, 2016Date of Patent: August 9, 2022Assignee: The Translational Genomics Research InstituteInventors: Cindy Liu, Lance B. Price
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Patent number: 11401499Abstract: The present invention relates to a method for providing a fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism, the method comprises the step of: (i) providing a main growth solution; (ii) optionally sterilizing the main growth solution provided in step (i); (iii) providing a trace metal solution; and (iv) mixing the main growth solution (as provided in step (i) or (ii)) with the trace metal solution provided in step (iii) and providing the fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism.Type: GrantFiled: February 28, 2018Date of Patent: August 2, 2022Assignee: UNIBIO A/SInventors: Subir Kumar Nandy, Ib Christensen, Budi Juliman Hidayat
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Patent number: 11382936Abstract: The invention provides compositions comprising bacterial strains for treating and preventing autoimmune and inflammatory disorders of the central nervous system.Type: GrantFiled: November 21, 2019Date of Patent: July 12, 2022Assignee: 4D Pharma Research LimitedInventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson
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Patent number: 11351205Abstract: The present invention generally relates to therapeutic compositions and methods for treating cancer patients. The compositions and methods can increase efficacy of an anti-cancer therapy, or treat, prevent, or inhibit an oncology-treatment induced condition (OTIC) induced by an anti-cancer therapy. The therapeutic compositions comprise microbial compositions and, optionally, an anti-cancer therapeutic agent. The methods comprise administering a therapeutic composition comprising a microbial composition and administering an anti-cancer therapy.Type: GrantFiled: December 3, 2021Date of Patent: June 7, 2022Assignee: Finch Therapeutics Holdings LLCInventors: Joseph Lobacki, Ulrich Thienel, Zain Kassam, Marina Santiago
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Patent number: 11318179Abstract: A topical cream or ointment is provided that provides for the binding to CB1 and/or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts.Type: GrantFiled: January 23, 2020Date of Patent: May 3, 2022Inventor: Jessica Kado
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Patent number: 11311631Abstract: Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative having reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic.Type: GrantFiled: September 6, 2017Date of Patent: April 26, 2022Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Svetomir N. Markovic, Wendy K. Nevala