Analysis, Diagnosis, Measuring, Or Testing Product (e.g., Specimen Preparation, Microscope Slide Smearing) Patents (Class 427/2.11)
  • Publication number: 20140193925
    Abstract: A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the conductive polymer, wherein the binding reagent has a specific affinity for the analyte. The conductive polymer can be deposited on a substrate by oCVD.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 10, 2014
    Inventors: Dhiman Bhattacharyya, Karen K. Gleason
  • Publication number: 20140186657
    Abstract: The present invention concerns a method for the treatment of stimulable phosphors and/or screens for use in diagnosis, in particular medical radiography. The method comprises subjecting the stimulable phosphors and/or screens to an epoxide containing gaseous compound, promptly following their manufacture. By applying the method according to the invention yellowing of the stimulable phosphors and/or screens is prevented in a safe and efficient manner; thereby the disadvantages known as such resulting from such yellowing will not occur.
    Type: Application
    Filed: May 23, 2012
    Publication date: July 3, 2014
    Inventors: Paul Leblans, Jean-Pierre Tahon
  • Publication number: 20140177809
    Abstract: An x-ray system includes x-ray tube containing a cathode which supplies electrons and an anode which can be maintained at high positive electrical potential to the cathode and has a target area which is impacted by electrons from the cathode when the positive potential is maintained generating x-rays. The x-ray tube is enclosed in a radiation resistant casing. The radiation resistant casing has a window which allows some of the x-rays generated at the target area to exit the system. The window has a vapor deposited layer of a filtering metal of sufficient thickness to effectively condition the x-rays passing through the window and located to intercept the x-rays passing through the window.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 26, 2014
    Inventors: Michael John Danyluk, William John Schaefer
  • Publication number: 20140170078
    Abstract: The invention relates to a magnetic resonance imaging T2 contrast medium (agent) for cell contrasting, and to a method for manufacturing the same. The magnetic resonance imaging T2 contrast agent for imaging at cellular level comprises magnetic nanoparticles exhibiting ferrimagnetism at room temperature, has a very high relaxivity, and has an effective uptake into cells. Thus, the T2 contrast agent may effectively mark various types of cells, and in vitro and in vivo magnetic resonance imaging at the single cell level may he realized.
    Type: Application
    Filed: June 14, 2011
    Publication date: June 19, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Taeghwan Hyeon, Nohyun Lee, Woo Kyung Moon, Seung Hong Choi, Hyoungsu Kim
  • Patent number: 8753813
    Abstract: The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: June 17, 2014
    Assignee: Northwestern University
    Inventors: Chad A. Mirkin, Adam B. Braunschweig, Jinan Chai, Dan J. Eichelsdoerfer, Louise R. Giam, Xing Liao, Lu Shin Wong
  • Patent number: 8753708
    Abstract: A solventless method for forming a coating on a medical electrical lead is described. The method includes combining particles of a therapeutic agent with a polymeric material in a flowable form in the absence of a solvent to form a uniform suspension. A predetermined amount of the suspension is dispensed onto a portion of the lead and is then cured to form the therapeutic agent eluting layer. Additional layers such as a primer layer, fluoro-opaque layer and/or a topcoat layer can be formed using the solventless method. Employing a solventless method may avoid contraction of the layer being formed due to solvent evaporation during the curing process, and may facilitate greater control over the thickness of the therapeutic agent eluting coating.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: June 17, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Larry L. Hum, James Q. Feng, Arienne P. Simon, Tolga Tas
  • Patent number: 8734890
    Abstract: A method for forming a molecularly imprinted polymer biosensor includes: (a) preparing a reaction solution including an imprinting molecule, a functional monomer, an initiator, and a crosslinking agent; (b) disposing the reaction solution in a space between upper and lower substrates each of which is made of a light-transmissible material; (c) disposing on the upper substrate a photomask having a patterned hole; (d) irradiating the reaction solution through the patterned hole of the photomask and the upper substrate so that the reaction solution undergoes polymerization to form a polymer between the upper and lower substrates; (e) removing the upper substrate after the polymer is formed on the lower substrate; and (f) extracting the imprinting molecule from the polymer so that a patterned molecularly imprinted polymer film is formed on the lower substrate.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: May 27, 2014
    Assignee: National Tsing Hua University
    Inventors: Chien-Chong Hong, Po-Hsiang Chang, Chih-Chung Lin
  • Publication number: 20140128832
    Abstract: The present disclosure relates to arrangements for attaching an RFID tag to a liquid container, and particularly to a blood components container. The RFID tag may be inserted in an enclosure, such as peel tab, or in a sealed cup attached to a container port. The tag could alternately be embedded in a molded plug or component attached to a port. The RFID antenna could be painted or stamped on the surface of the container. Or the tag could be inserted into the container to float freely in the liquid components. The RFID source may be secured around the neck of a rigid or semi-rigid container, attached with a tether or attached to a connector assembled in association with a blood component or other fluid flow path.
    Type: Application
    Filed: March 7, 2013
    Publication date: May 8, 2014
    Applicant: Fenwal, Inc.
    Inventors: Christine Larson, Bryan Blickhan, Carlos Calderon, Daniel Lynn, Senan Ozbag, W. Timothy Watts, Daryl R. Calhoun
  • Publication number: 20140102899
    Abstract: The invention provides a composition including DNA bonded to a plasma-treated surface, the plasma can be any suitable plasma, such as an argon plasma, a compressed air plasma, a flame-based plasma or a vacuum plasma. Surfaces treatable by the methods of the invention include ceramic, metal, fabric and organic polymer surfaces. The DNA can be any DNA, such as a marker DNA, which can be linear or circular, single-stranded or double stranded and from about 25 bases to about 10,000 bases in length. Also provided is a method of binding DNA to a surface, including the steps of exposing the surface to a plasma to produce a plasma-treated surface; and applying DNA to the plasma-treated surface to produce surface bound DNA on the treated surface.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 17, 2014
    Inventors: Abdelkrim BERRADA, MingHwa Benjamin LIANG, James A. HAYWARD, Lawrence A. JUNG
  • Publication number: 20140099425
    Abstract: A method is proposed for fabricating small-scale, curved structures. Firstly, a calligraphy paper or filter paper is provided. Liquid-phase material droplets are applied to calligraphy paper or filter paper to form a desired pattern at a contact angle that can form convex curved small-scale structures.
    Type: Application
    Filed: September 17, 2013
    Publication date: April 10, 2014
    Applicant: National Tsing Hua University
    Inventors: Ting-Ya Chang, Chao-Min Cheng, Kuan-Hung Chen
  • Publication number: 20140093909
    Abstract: The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA).
    Type: Application
    Filed: December 12, 2013
    Publication date: April 3, 2014
    Applicant: TriPath Imaging, Inc.
    Inventors: William A. Fox, William Carl Ray, III
  • Patent number: 8685486
    Abstract: Methods of and systems for applying blocking material to assay substrates are disclosed. A method includes supplying an assay substrate having at least one surface. A first portion of the surface of the substrate has at least one analysis feature thereon, and a second portion of the surface of the substrate lacks analysis features. The method also includes generating a spray of a blocking material in proximity to the surface of the substrate and continuing the spray generation in proximity to the surface of the substrate at least until the second portion of the surface of the substrate is substantially covered by the blocking material.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: April 1, 2014
    Assignee: Aushon Biosystems, Inc.
    Inventors: Kevin Oliver, Toni Holway, Travis Sullivan
  • Publication number: 20140081150
    Abstract: Methods for fabricating metal nano-particle embedded enhancement substrates used for surface enhanced Raman spectroscopy (SERS) including ion implanting metal nano-particles into the substrate and etching the substrate to partially expose the metal nano-particles. The resulting material is useful as a SERS substrate for detection of molecules adsorbed on it by surface enhanced Raman spectroscopy.
    Type: Application
    Filed: August 5, 2013
    Publication date: March 20, 2014
    Inventors: Wei-Kan Chu, Dharshana N. Wijesundera, Indrajith Rajapaksa
  • Patent number: 8673386
    Abstract: Disclosed herein is a composition for glucose sensing obtained by dispersing in a solvent such as acetone a nanofibrous membrane fabricated by electrospinning a mixture containing poly(vinylidene fluoride) and poly(aminophenylboronic acid). Also disclosed is a method of fabricating a non-enzymatic glucose biosensor based on an electrospun nanofibrous membrane by depositing the composition on an electrode.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 18, 2014
    Assignee: Kyungpook National University Industry Academic Cooperation Foundation
    Inventors: Kwang Pill Lee, Iyengar Gopalan Anantha, Sundaram Komathi Shanmuga
  • Publication number: 20140065291
    Abstract: A slide stainer and a method for operating the slide carrier is disclosed. The slide stainer includes a slide carrier that carries one or more laboratory slides; a vessel that is capable of carrying fluid for staining the laboratory slides and that is sized to accommodate the laboratory slides; a slide transporter that moves the slide carrier into and out of the vessel; and a spring loaded pin that engages with a surface of the slide stainer to limit free-fall translation of the slide carrier in an event of a power loss. Additionally, during an agitation phase of a slide staining process, the slide transporter is configured to translate the slide carrier in an upward direction to a pre-determined height that is set by a user of the slide stainer, and the slide transporter translates the slide carrier in a downward direction back into the vessel.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 6, 2014
    Applicant: Rushabh Instruments, Inc.
    Inventor: Preyas Shah
  • Publication number: 20140058487
    Abstract: An implantable lead for stimulating patient tissue includes a lead body. A jacket is disposed over at least a portion of a length of the lead body. The jacket has an outer surface and an opposing inner surface. At least a portion of the outer surface of the jacket forms at least a portion of an outer surface of the lead. At least a portion of the inner surface of the jacket is open to the lead body. The jacket defines apertures each extending completely through the jacket. Electrodes are disposed along a distal end of the lead body. Terminals are disposed along a proximal end of the lead body. Conductors electrically couple the electrodes to the terminals. Conductor insulation is disposed over each of the conductors. At least a portion of the conductor insulation is in fluid communication with the local environment external to the lead via the apertures.
    Type: Application
    Filed: August 8, 2013
    Publication date: February 27, 2014
    Inventors: Matthew Lee McDonald, Michael X. Govea
  • Patent number: 8652584
    Abstract: A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: February 18, 2014
    Assignee: Corning Incorporated
    Inventors: Xiaoxi (Kevin) Chen, William Galbraith
  • Publication number: 20140037552
    Abstract: The invention relates to a Prussian Blue based nanoparticle comprising a Prussian Blue based metal core doped with one or more metal isotope and an organic biocompatible coating. The invention relates furthermore to a process for the preparation of said nanoparticle, and the use thereof as imaging contrast material or in the therapy.
    Type: Application
    Filed: February 15, 2012
    Publication date: February 6, 2014
    Inventors: Domokos Máthé, Krisztián Szigeti
  • Patent number: 8642111
    Abstract: Methods using light force to fabricate WGM sensors including microresonators having target receptors selectively and substantially provided at only ribbon area of the microresonators.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: February 4, 2014
    Assignee: Polytechnic Institute of New York University
    Inventors: Stephen Arnold, Stephen Holler, Ta Kang Keng, Siyka Shopova
  • Publication number: 20140017123
    Abstract: Disclosed herein are analytical aids having a surface coated at least partially with a hydrophilic coating, where the hydrophilic coating includes nanoparticles with silica structure and an average particle size in a range from about 1 nm to about 500 nm. Also disclosed are methods of producing the analytical aids, as well as using the analytical aids in, for example, a sampling device containing the at least partially coated analytical aid.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Branislav Babic, Peter Greiwe
  • Patent number: 8609178
    Abstract: A substrate (1) for spatially selective micron and nanometer scale deposition and/or reaction, which has a support (3), a conductive layer (5) on the support, a dielectric layer (7) to hold an electrostatic charge pattern such as a photoconductive layer of a material which dissipates an electric charge upon receiving incident radiation thereon, and a chemically functional layer (9), such that electrostatic charge patterns may be formed in a predetermined manner upon the substrate to influence the movement of charged droplets in an emulsion (15) on the substrate. The chemically functional layer either provides a surface for chemical functionalization of the substrate or prevents access or reaction to the dielectric or photoconductive layer.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: December 17, 2013
    Assignee: Raustech Pty Ltd
    Inventors: Peter John Hastwell, Timothy Mark Kaethner
  • Publication number: 20130323182
    Abstract: The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.
    Type: Application
    Filed: February 6, 2012
    Publication date: December 5, 2013
    Inventors: Taeghwan Hyeon, Yuanzhe Piao, Yong Il Park
  • Patent number: 8597715
    Abstract: A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular component of a tissue section and the transfer surface is a film that can be focally altered to adhere the target to the transfer surface. Subsequent separation of the film from the tissue section selectively removes the adhered target from the tissue section. The transfer surface is activated from within the target to adhere the target to the transfer surface, for example by heating the target to adhere it to a thermoplastic transfer surface. Such in situ activation can be achieved by exposing the biological sample to an immunoreagent that specifically binds to the target (or a component of the target).
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: December 3, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael R. Emmert-Buck, Michael Anthony Tangrea, Robert F. Bonner, Rodrigo Chuaqui, Thomas J. Pohida
  • Publication number: 20130316180
    Abstract: A method for forming an electrical-conductor-free vapor barrier suitable for protecting long-term implanted electronic systems is disclosed. The method comprises forming a nascent layer of a partially cured layer and repeatedly compressing the layer via a roller-based process. Once the layer has been suitably compressed, the layer is fully cured. In some embodiments, a multi-layer protective layer is formed by repeating the roller-based formation process for each of a plurality of layers. In some embodiments, a multi-layer protective layer comprising layers of different materials is formed.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 28, 2013
    Applicant: Case Western Reserve University
    Inventors: Wen H. Ko, Shem Lachman, Christian A. Zorman, Leping Bu
  • Publication number: 20130309395
    Abstract: A biological test member, and method of making the same, is disclosed with the member including a substrate. The test member has usefulness, for example, in testing a person's blood glucose level. A first layer and a second layer of conductive metal are printed or otherwise applied on the substrate in an electrode pattern. The metal or metals are cured or sintered at a low, non-damaging temperature, such as by applying one or more pulses of a high-energy broad spectrum light. A layer of reagent may be provided on said second metal layer.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 21, 2013
    Inventor: Abner David Joseph
  • Publication number: 20130295273
    Abstract: A solution and a method of treating a substrate with the solution is disclosed. The solution includes a polar liquid component and at least 2% by weight based upon the total weight of said solution of an adduct that is different from the polar liquid component. The adduct comprises at least one of: (D) NH2Y(HNCO(AO)XOR)Z1; (E) (RO(AO)X CONH)Z2YHNCONHY(HNCO (AO)XOR)Z3; and (F) Y(HNCO(AO)XOR)Z4 where Y is an aromatic core derived from an aromatic isocyanate component; A is an alkylene group selected from the group of ethylene groups, propylene groups, butylene groups, and combinations thereof; R is a hydrocarbon group having from 1 to 20 carbon atoms; X is at least 6; Z1 is at least 1; Z2 is at least 1; Z3 is at least 1; and Z4 is at least 2. Further, the adduct is substantially free of unreacted isocyanate groups.
    Type: Application
    Filed: April 29, 2013
    Publication date: November 7, 2013
    Inventors: Glenis R. Mente, Donald C. Mente, John P. Erickson
  • Publication number: 20130282090
    Abstract: A lead for use in neural stimulation comprises a core section having a proximal end and a distal end. A plurality of electrodes is coupled to the core section proximate the distal end. At least one contact is coupled to the core section proximate the proximal end. At least one thin film is wound around the core section from the proximal end to the distal end and electrically coupling the at least one contact and the plurality of electrodes. The at least one thin film forms a curved substantially planar shape in a relaxed state before being wound around the core section.
    Type: Application
    Filed: April 18, 2013
    Publication date: October 24, 2013
    Applicant: Sapiens Steering Brain Stimulation B.V.
    Inventors: Michel Marcel Jose Decré, Edward Willem Albert Young, Jacobus Adrianus Johanna Maria Deckers, Dirk van Pijkeren, Ke Wang, Vincent Adrianus Henneken
  • Publication number: 20130267801
    Abstract: Embodiments of the present invention relate to analyte sensors comprising a heparin coating, and methods of coating analyte sensors. The heparin can be stably associated with at least a portion of a porous membrane that covers a portion of the analyte sensors. The heparin can be photochemically linked to the coating through the formation of covalent bonds.
    Type: Application
    Filed: May 14, 2013
    Publication date: October 10, 2013
    Inventors: Matthew A. Romey, Soya Gamsey, David R. Markle
  • Publication number: 20130237789
    Abstract: An electrode for measuring electrical activities of a living body and/or for outputting electrical signals into the living body, with an electrically insulated and flexible line, which is connected fixedly or releasably to a distally arranged and electrically conductive electrode tip. The electrode tip is designed for insertion into the body. The electrode tip includes at least one crystalline shape-memory material, and the electrode tip is flexible on account of the shape-memory material. The shape-memory material of the support structure is formed at least partially by physical vapour deposition, in such a way that precipitations in the shape-memory material have a maximum size of 500 nm.
    Type: Application
    Filed: May 6, 2011
    Publication date: September 12, 2013
    Applicant: ACANDIS GMBH & CO. KG
    Inventor: Giorgio Cattaneo
  • Publication number: 20130236630
    Abstract: Disclosed are antifouling compositions that can include a biopolymeric matrix which is substantially zwitterionic. The compositions may include a biopolymer matrix having positively charged functional groups, negatively charged functional groups, zwitterionic functional groups, or a combination thereof, such that the composition is substantially zwitterionic. The compositions can be used as additives and as compositions further containing a base material such as paint or lacquer. Methods of making and using such compounds and compositions are also disclosed.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 12, 2013
    Inventor: Glen Leon Brizius
  • Publication number: 20130224120
    Abstract: Disclosed herein are compositions of a multimodal detection agent and methods of fabricating the same. The multimodal detection agent comprises a plurality of metallic nanoparticles attached to a surface of a polymeric carrier. The detection agent further comprising one or more target-specific binding agents attached to the metallic nanoparticles or the polymeric carrier.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 29, 2013
    Inventors: Mansoor M. Amiji, Srinivas Ganta, Pei-Chin Tsai
  • Publication number: 20130209368
    Abstract: The present invention provides particles comprising either a water-soluble polymer or a phospholipid, wherein at least one near infrared (NIR) fluorescent probe and optionally at least one active agent such as a targeting moiety, capable of selectively recognizing a particular cellular marker, are non-covalently bound to the outer surface of the particles.
    Type: Application
    Filed: September 8, 2011
    Publication date: August 15, 2013
    Inventors: Shlomo Magdassi, Philip Lazarovici, Liraz Larush, Emma Portnoy, Shimon Lecht, Ran Tivony
  • Patent number: 8501416
    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analysis due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: August 6, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Vincent Linder, Samuel K. Sia, George M. Whitesides, Max Narovlyansky, Adam Siegel
  • Patent number: 8501272
    Abstract: Optically anisotropic spheres that can be used as pixel elements in rotating element displays are fabricated by partially (e.g., hemispherically) coating a plurality of spheres by transfer coating methods. Typically, a monolayer of spaced apart monochromal (e.g., white) spheres is formed on a support surface by, for example, making use of a removable template matrix. Next, a uniform layer of viscous coating material (e.g., black coating) is applied to the monolayer of spheres to transfer at least some of the coating material onto the surface of spheres in a monolayer. The obtained partially coated spheres are optionally cured by a UV or thermal exposure and are then removed from the support substrate. In some embodiments, coating material also provides electrical anisotropy to the spheres. Transfer coating methods result in improved precision of hemispherical coating and allow use of environmentally robust pixel elements.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: August 6, 2013
    Assignee: Cospheric LLC
    Inventors: Yelena Lipovetskaya, Brian Gobrogge
  • Publication number: 20130195766
    Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 1, 2013
    Inventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
  • Publication number: 20130197319
    Abstract: The present invention includes a flexible sensor suitable for contact with skin comprising: a nanocomposite; and a top layer; where the sensor provides in-situ detection in sweat or other aqueous body fluids at the skin surface of at least one physiological parameter selected from the group consisting of a physiological salt component, temperature, moisture, humidity, or combinations thereof. The present invention further includes a method of fabricating a flexible sensor suitable for contact with skin comprising: electrospinning at least one polyamide-producing monomer to form a non-conductive polyamide substrate; attaching at least one plurality of conductive nanoscale attachments, wherein the nanoscale attachments are selected from nanotubes, nanoparticles, or combinations thereof, to form an intermediate layer; and functionalizing the intermediate layer to form a top layer.
    Type: Application
    Filed: January 28, 2013
    Publication date: August 1, 2013
  • Publication number: 20130177695
    Abstract: A method of manufacturing an end effector for a surgical instrument includes providing a substrate wherein at least an outer periphery of the substrate is formed from an electrically-insulative material. The method further includes forming at least one ridge on the outer periphery of the substrate and depositing an electrically-conductive material onto the at least one ridge to form at least one electrode.
    Type: Application
    Filed: January 10, 2012
    Publication date: July 11, 2013
    Applicant: TYCO Healthcare Group LP
    Inventors: Ronald J. Podhajsky, William S. Darrow, Kristel L. Ambrosius
  • Patent number: 8475886
    Abstract: A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: July 2, 2013
    Assignee: Corning Incorporated
    Inventors: Xiaoxi (Kevin) Chen, William Galbraith
  • Patent number: 8478073
    Abstract: A method for determining a position of an area of an object within the complete object, wherein the image of the area of the object is contained within a field of view of a microscope. The method comprises acquiring high magnification image data representing an image of the field of view of the microscope, typically from a digital camera attached to the microscope; processing the high magnification image data to reduce the resolution thereof; comparing the processed high magnification image data with portions of the low magnification image data, and determining said position based on the results of said comparison.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: July 2, 2013
    Assignee: Hamamatsu Photonics K.K.
    Inventor: John R. Maddison
  • Patent number: 8470524
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: June 25, 2013
    Assignee: Theranos, Inc.
    Inventors: Ian Gibbons, Michael O'Connell
  • Publication number: 20130150689
    Abstract: The present invention relates to a device for sensing a target chemical. The device includes a flexible, non-planar substrate; a printed, solid-state sensing element comprising a chemical sensing material which produces an electrical signal upon interaction with the target chemical; a first printed electrode comprising a first conductive composition; and a second electrode comprising a second conductive composition. The first and second electrodes are electrically isolated from one another, and one or both of the first and second electrodes is in electrical contact with said sensing element. The first and second electrodes and the sensing element collectively form an electrochemical sensor which is coupled to the flexible, non-planar substrate. Medical devices comprising the device of the present invention and methods of making a device for sensing a target chemical are also disclosed.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 13, 2013
    Inventor: Micropen Technologies Corporation
  • Patent number: 8460744
    Abstract: A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a transfer surface. Also described is an automated system for transferring tissue from a tissue sample to a transfer substrate. The system includes means for holding a tissue section that includes targets specifically stained with an absorptive stain thereby resulting in a stained tissue surface, and a flexible transfer film that includes a lower thermoplastic layer in sufficient thermal contact with the stained tissue surface; an irradiating assembly configured to provide a predetermined uniform light dose to the entire tissue section; and means for applying a constant pressure to the transfer film during irradiation.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: June 11, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Robert F. Bonner, Thomas J. Pohida, Michael R. Emmert-Buck, Michael Anthony Tangrea, Rodrigo F. Chuaqui
  • Publication number: 20130129910
    Abstract: A method for producing a bilayer of amphipathic molecules comprising providing a hydrated support and providing a hydrophilic body, and bringing the hydrated support and hydrophilic body into contact to form a bilayer of amphipathic molecules. A bilayer produced by the method of the invention, and uses of the bilayer.
    Type: Application
    Filed: October 16, 2012
    Publication date: May 23, 2013
    Applicant: lsis Innovation Limited
    Inventor: lsis Innovation Limited
  • Patent number: 8445212
    Abstract: Disclosed are a micro-fluidic structure for detecting biomolecules and a micro-fluidic device having the same. More particularly, a target material including at least two cis-diols is detected by a first material containing a boronate moiety and a second material containing another boronate moiety while generating electrical signals.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: May 21, 2013
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Jong Myeon Park, Won Yong Lee, Han Nim Choi, Jung Hoon Lee
  • Publication number: 20130116530
    Abstract: A method of manufacturing an electrode for medical use, such as an intracerebral electrode (1) intended for use at brain level, the electrode having the shape of a narrow and elongated rod and including at least one electrical contact pad (2, 4) connected to an electrical conductor intended to be connected to a processing device and/or a recording device. In order to realize the electrode (1), a substrate (10) having a tridimensional shape is used and a metal layer is deposited on a periphery of the substrate (10) by a physical vapor deposition technique through a mask (12) that determines a pattern arranged so as to define at least the electrical contact pad (2, 4).
    Type: Application
    Filed: June 30, 2011
    Publication date: May 9, 2013
    Inventor: Jean-Pierre Darnis
  • Publication number: 20130110105
    Abstract: An electrode for use in electrosurgery. The active tip or edge of the electrode carries a non-stick (to tissue) coating of carbon or graphite and a protein material. The coating is at least 10 m thick and supports a high voltage discharge of at least 1000 volts. The coating is formed by dipping the electrode into a mixture of carbon or graphite powder and a liquid binder, then drying the coating.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 2, 2013
    Applicant: PEAK Surgical, Inc.
    Inventor: Alexander B. VANKOV
  • Patent number: 8431344
    Abstract: A method of fabrication or manufacture at micrometer and nanometer scale by spatially selective deposition of chemical substances so as to form a solid phase array on a substrate (10) which includes the steps of defining a region (15) on the substrate by forming an electrostatic charge on that region which is different from the electrostatic charge on other regions of the substrate such as by formation of a latent electrostatic image thereon, applying an emulsion to the substrate. The emulsion (16) has an electrically charged discontinuous phase and a component to be selectively deposited carried in or comprising the discontinuous phase. The discontinuous phase of the emulsion is attracted to the preselected region by attraction by the electrostatic charge on the region and deposition obtained with or without reaction. The electrostatic image may be formed by the use of photoconductor.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: April 30, 2013
    Assignee: Raustech Pty Ltd
    Inventors: Peter John Hastwell, Timothy Mark Kaethner
  • Publication number: 20130095043
    Abstract: The present invention relates to a method of forming iron oxide nanoparticles comprising the steps of (a) suspending iron oxide/hydroxide and oleic acid or a derivative thereof in a primary organic solvent; (b) increasing the temperature of the suspension by a defined rate up to a maximum of 340° C. to 500° C.; (c) aging the suspension at the maximum temperature of step (b) for about 0.5 to 6 h; (d) cooling the suspension; (e) adding a secondary organic solvent; (f) precipitating nanoparticles by adding a non-solvent and removing excess solvent; (g) dispersing said nanoparticles in said secondary organic solvent; (h) mixing the dispersion of step (g) with a solution of a polymer; and (i) optionally removing said secondary organic solvent.
    Type: Application
    Filed: June 21, 2011
    Publication date: April 18, 2013
    Inventors: Dirk Burdinski, Carmen Bohlender, Nicole P.M. Haex
  • Publication number: 20130095563
    Abstract: Aspects and embodiments are directed to methods and systems of detecting an analyte present in the environment. More particularly, this disclosure relates to methods and systems of detecting a threatening or dangerous analyte that may increase survivability of an individual or group of individuals.
    Type: Application
    Filed: February 15, 2012
    Publication date: April 18, 2013
    Inventors: Timothy J. Imholt, Susan N. Gottschlich
  • Publication number: 20130066182
    Abstract: Improved low-cost, highly reliable methods for increasing the electrochemical surface area of neural electrodes are described. A mono-layer of polymeric nanospheres is first deposited on a metallization supported on a dielectric substrate. The nanospheres self-assemble into generally repeating lattice forms with interstitial space between them. Then, the geometric surface area of the metallization material is increased by either selectively etching part-way into its depth at the interstitial space between adjacent nanospheres. Another technique is to deposit addition metallization material into the interstitial space. The result is undulation surface features provided on the exposed surface of the metallization. This helps improve the electrochemical surface area when the treated metallizations are fabricated into electrodes.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 14, 2013
    Applicant: NeuroNexus Technologies, Inc.
    Inventor: John P. Seymour