Analysis, Diagnosis, Measuring, Or Testing Product (e.g., Specimen Preparation, Microscope Slide Smearing) Patents (Class 427/2.11)
  • Patent number: 8008068
    Abstract: A nonhemolytic sensor for determination of analytes in erythrocyte-containing biological fluids is disclosed that comprises an optical material having a deposit on a surface thereof, where this deposit includes an analyte-reactive reagent and a particulate means for suppressing hemolysis of erythrocytes in an erythrocyte-containing biological fluid, such as whole blood. Thus, a porous array of negatively charged particles, e.g., polymeric beads having a plurality of carboxylate surface groups, are disposed on a sampling surface of an optical sensor, and suppress hemolysis of erythrocytes coming into contact with the sampling surface. In the case of an optical sensor, such particles can simultaneously enhance reflectance of a light beam transmitted through the optical material to the sampling surface site.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: August 30, 2011
    Assignee: Light Pointe Medical, Inc.
    Inventor: Hiroshi Nomura
  • Patent number: 8008034
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: August 30, 2011
    Assignee: Theranos, Inc.
    Inventors: Ian Gibbons, Michael O'Connell
  • Publication number: 20110206619
    Abstract: The various embodiments herein provide a gold coated SPIONs with jagged surface. The gold coated SPIONs have a core and a shell. The core is a SPION molecule and the shell is a jagged gold layer. A non-uniform polymeric gap exists between the core and the shell. The embodiments also provide a method of producing the jagged gold coated SPIONs by mixing a colloidal dispersion of SPIONs with pH sensitive polymers. Adding a gold salt to the above mixture and reducing the gold salt to form jagged gold coated SPIONs.
    Type: Application
    Filed: April 30, 2011
    Publication date: August 25, 2011
    Inventors: Morteza Mahmoudi, Mohammad Ali Shokrgozar
  • Publication number: 20110200948
    Abstract: A new and novel method utilizing current nano-technological processes for fabricating a range of micro-devices with significantly expanded capabilities, unique functionalities at microscopic levels, enhanced degree of flexibilities, reduced costs and improved performance in the fields of bioscience and medicine is disclosed in the within patent application. Micro-devices fabricated using the disclosed nano-technological techniques have significant improvements in many areas over the existing, conventional methods. Such improvements include, but are not limited to reduced overall costs, early disease detection, targeted drug delivery, targeted disease treatment and reduced degree of invasiveness in treatment. Compared with existing, conventional approaches, the said inventive approach disclosed in this patent application is much more microscopic, sensitive, accurate, precise, flexible and effective.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 18, 2011
    Inventor: Chris Yu
  • Publication number: 20110189493
    Abstract: The present invention relates to the use of a crosslinked, silicon-containing layer containing, substantially consisting of or consisting of silicon, O, C, H, optionally N which can be produced by plasma polymerization and/or crosslinking of organosilicon liquids by a plasma process and/or UV radiation of a wavelength of less than 250 nm, without using metals of an atomic number of more than 14, as a biocompatible surface, for imparting to a surface or providing a surface with a non-genotoxic effect. The invention also relates to correspondingly coated articles and to processes for the production thereof.
    Type: Application
    Filed: July 31, 2009
    Publication date: August 4, 2011
    Inventors: Matthias Ott, Ingo Grunwald, Dirk Salz, Michael Wagener, Klaus-Dieter Vissing, Wolfgang Hielscher, Christopher Dölle
  • Patent number: 7988685
    Abstract: The invention provides hydrogel compositions, components, and hydrogel-actuated or mediated devices, and methods for the incorporation of hydrogel microscale components in microscale devices and systems. The methods and devices result in active microvalves that are useful in microfluidic applications, including analyte sensing, in process chemical and fermentation stream monitoring, and drug delivery. In particular, the devices are useful for controlled drug delivery either in response to a pre-determined stimulus or for pulsatile delivery.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: August 2, 2011
    Assignee: Regents of the University of Minnesota
    Inventors: Babak Ziaie, Ronald A. Siegel, Yuandong Gu, Antonio Baldi, Gauri P. Misra, Paul E. Loftness, Ming Lei
  • Publication number: 20110165086
    Abstract: Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.
    Type: Application
    Filed: December 29, 2010
    Publication date: July 7, 2011
    Inventors: Chulhyun Lee, Sung Lan Jeon, Min Kyung Chae, Jee-Hyun Cho, Eun Ju Jang
  • Patent number: 7964414
    Abstract: The present invention provides a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The biosensor of the invention includes a substrate having at least two types of surfaces on a single plane, wherein at least one of the surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to the surface that does not retain a physiologically active substance.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: June 21, 2011
    Assignee: Fujifilm Corporation
    Inventors: Toshihide Ezoe, Taisei Nishimi, Yukou Saito
  • Patent number: 7955638
    Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: June 7, 2011
    Assignee: Graffinity Pharmaceuticals AG
    Inventors: Stefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
  • Publication number: 20110104509
    Abstract: The present invention relates to a method for increasing hydrophilicity of part or all of a surface of a polymer substrate to change the ability of a polymer surface to bond, allowing better adhesion or printability, by a surface treatment which increases the surface energy stabilised by several washing steps.
    Type: Application
    Filed: May 27, 2009
    Publication date: May 5, 2011
    Applicant: AO TECHNOLOGY AG
    Inventors: Alexandra H.C. Poulsson, Robert Geoffrey Richards
  • Patent number: 7931933
    Abstract: Solder paste application, inspection and correction. Following or during application of solder paste on a substrate, the result thereof is inspected and any detected errors are registered. Following an evaluation as to whether correction of these errors is required and if it would be worthwhile, the errors are corrected. The correction involves removing solder paste from locations where so required, and jetting of additional solder paste to locations where so required.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: April 26, 2011
    Assignee: Mydata Automation AB
    Inventors: William Holm, Nils Jacobsson
  • Publication number: 20110092768
    Abstract: A device for in-vivo detection comprises a housing having an optical window and enclosing an imager that is configured to image the optical window. An external surface of the optical window has trypsin immobilized thereon, and may also be coated with a steric barrier protection, which may be polyethylene glycol (PEG). A trypsin-Alpha-1-antitrypsin complex formed on the window may have an affinity to a binding agent, which is tagged by a tag selected from a group consisting of a colorant, a fluorescent moiety, and a radioactive moiety.
    Type: Application
    Filed: November 2, 2008
    Publication date: April 21, 2011
    Applicant: GIVEN IMAGING LTD.
    Inventors: Noam Emanuel, Emil-Israel Katz, Elena Khazanov, Abraham Rubinstein, Yechezkel Barenholz, Abdel Kareem Azab
  • Patent number: 7927651
    Abstract: There is provided a biosensor capable of increasing a detecting sensitivity of a target substance of glutamate, by using a nano wire having excellent electrical characteristics and by immobilizing a receptor of glutamate to be detected on a substrate which is disposed between a nano wire and another nano wire and a method for manufacturing the same. The biosensor for detecting glutamate according to the present invention can be manufactured with an arrangement in which the nano wire is selectively arranged on a solid substrate in a matrix. Since this biosensor can prevent the degradation of the nano wire in the electrical characteristic, it can sensitively detect glutamate even through a small amount thereof is contained in a food so that it can be effectively used in detecting the food additive existing in the processed foodstuffs.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: April 19, 2011
    Assignees: Seoul National University Industry Foundation, Mitech Corporation
    Inventors: Seung-Hun Hong, Byung-Yang Lee, Dong-Joon Lee
  • Patent number: 7923054
    Abstract: A substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure and a functional layer attached to the interlayer, the functional layer having functional sites with a density of at least 50 nanomoles/cm2.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: April 12, 2011
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Anit Dutta, Heidi Flannery, William P. Mortimer, Jr.
  • Patent number: 7919138
    Abstract: Methods of attaching a ligand to a surface are described that include contacting a surface with a substrate containing an amphiphilic comb polymer. The substrate is configured to provide a pattern of the amphiphilic comb polymer on a selected region of the surface. The substrate can be separated from the surface leaving the amphiphilic comb polymer on the selected region of the surface, thus providing a selected region of the surface having amphiphilic comb polymer on it. A ligand can then be deposited on the surface such that the selected region of the surface having the amphiphilic comb polymer is substantially free of the ligand.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: April 5, 2011
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Zhongping Yang, Jinho Hyun
  • Publication number: 20110070355
    Abstract: High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 24, 2011
    Inventors: Vincent Peter Bavaro, John Arthur Simpson, Peter D'Aquanni, Aaron Baldwin
  • Patent number: 7910152
    Abstract: A method of forming a coating on a medical device having a controlled morphology is described.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: March 22, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar Walter Kleiner, Jessica Reneé DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
  • Publication number: 20110062318
    Abstract: A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighbouring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 17, 2011
    Inventors: Charles-Etienne Bisaillon, Guy Lamouche, Marc L. Dufour
  • Publication number: 20110064674
    Abstract: A method of manufacture of a luminescent nanoparticle probe system includes forming a bismuth sulfide core; and coating the bismuth sulfide core with a shell.
    Type: Application
    Filed: May 21, 2009
    Publication date: March 17, 2011
    Inventors: Marcel Bruchez, Traian Sarbu
  • Patent number: 7906183
    Abstract: A process for making a support for an electrophoretic medium comprising the steps of: applying an agarose coating to a corona treated polymeric film by transferring a layer of agarose solution onto a surface of the corona treated polymeric film. The pH of the agarose solution can be generally maintained between about 8 and about 11 and the concentration of the agarose solution can be generally maintained between about 0.1 and about 0.4% agarose by weight. The agarose powder used to make the agarose solution can be pre-treated by introducing a fresh reducing atmosphere above the agarose powder and exposing the agarose powder to a reducing atmosphere. The reducing atmosphere treatment may be repeated at least three times.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: March 15, 2011
    Assignee: Helena Laboratories Corporation
    Inventor: Philip A. Guadagno
  • Patent number: 7901945
    Abstract: A system and method for recognition of images may include the use of alignment markers. The image recognized may be a pattern from an array, a character, a number, a shape, and/or irregular shapes. The pattern may be formed by elements in an array such as an identification marking and/or a sensor array. More particularly, the system and method relate to discriminating between images by accounting for the orientation of the image. The size and/or location of alignment markers may provide information about the orientation of an image. Information about the orientation of an image may reduce false recognitions. The system and method of image recognition may be used with identification markings, biosensors, micro-fluidic arrays, and/or optical character recognition systems.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: March 8, 2011
    Assignee: Board of Regents the University of Texas System
    Inventors: Jason E. Meiring, Timothy B. Michaelson, C. Grant Willson
  • Publication number: 20110053800
    Abstract: The present invention relates to a method of manufacturing a patterned substrate for culturing cells, comprising the steps of: (1) preparing a substrate; (2) forming a first plasma polymer layer by integrating a first precursor material using a plasma on the substrate; (3) placing a shadow mask having a predetermined pattern on the first plasma polymer layer; and (4) forming a second patterned plasma polymer layer by integrating a second precursor material using a plasma.
    Type: Application
    Filed: August 31, 2010
    Publication date: March 3, 2011
    Applicant: SUNGKYUNKWAN UNIVERSITY Foundation for Corporate Collaboration
    Inventors: Dong Geun Jung, Chang Rok Choi, Kyung Seop Kim
  • Publication number: 20110053270
    Abstract: A method for forming a pattern-coated substrate includes disposing a composition comprising a polysaccharide-based polymer on a substrate to generate a coated substrate. The polysaccharide-based polymer composition is substantially free of cross-linking monomers. The method further includes exposing a portion of the coated substrate to a first dose of UV radiation to induce crosslinking of the polysaccharide-based polymer, wherein a portion of the substrate is shielded from the ionizing radiation. The UV exposed coated substrate may be washed or hydrated to remove uncross-linked polysaccharide-based polymer.
    Type: Application
    Filed: August 25, 2010
    Publication date: March 3, 2011
    Inventors: Theresa Chang, Robert Randall Hancock, JR., Trista Nicole Hesch, Michael Lesley Sorensen, Ruchirej Yongsunthon
  • Publication number: 20110044857
    Abstract: A method of fabricating a biosensor chip includes: forming at least one metallic layer on a transparent substrate to form a composite member; disposing the composite member in a vacuumed chamber, and introducing a gas into the vacuumed chamber; applying microwave energy to the gas to produce a microwave plasma of the gas within the vacuumed chamber, and causing the microwave plasma to interact with the metallic layer so that the metallic layer is melted and formed into a plurality of metallic nanoparticles that are spaced apart from each other and that expose partially the surface of the transparent substrate; and disposing a receptor at the surface of the transparent substrate that is exposed among the metallic nanoparticles. A biosensor chip is also disclosed.
    Type: Application
    Filed: August 18, 2010
    Publication date: February 24, 2011
    Inventors: Kuan-Jiuh Lin, Chuen-Yuan Hsu
  • Patent number: 7892594
    Abstract: A system and method for using gradient nanotopography to increase mammalian cell attachment and cell confinement on surfaces. A surface platform consisting of a thin film of gold possessing a gradient of topography on the surface and self-assembled monolayers of alkanethiols presenting desired functional groups is formed. A gradient in the chemical properties is induced in the terminal groups of the monolayer because of the continuous increase in the surface area and the anisotropy of gold film structure. The gradient nanotopraphy provides simultaneous control of two key properties, the presentation of the terminal functional groups and a continuous increase in the surface density of functional groups on the surface. This control provides for drug screening assays using adherent cell-based experiments.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: February 22, 2011
    Assignee: Syracuse University
    Inventors: Yan Yeung Luk, Karen A. Simon, Erik A. Burton, Prerli Sejwal, YongBin Han
  • Patent number: 7887890
    Abstract: Provided is a method of manufacturing a plastic substrate with lower auto-fluorescence and better specificity. The method includes: (a) preparing a plastic substrate having an Atomic Force Microscopic (AFM) surface roughness of Ra<3 nm or Rq<4 nm under the condition of 50 ?m×50 ?m or less; (b) treating the plastic substrate with plasma; and (c) treating the plastic substrate with a surface-modifying monomer. A plastic substrate manufactured by the method is also provided. The plastic substrate exhibits a remarkably low auto-fluorescence and thus better specificity for detection of target biomolecules, which enables the broad application of a plastic substrate, which can be easily designed to include a microfluidic structure relative to a glass substrate but has been limitedly used due to high auto-fluorescence, to microarrays, biochips, or well plates.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: February 15, 2011
    Assignees: LG Chem, Ltd., LG Life Sciences, Ltd.
    Inventors: Gihune Jung, Jinseok Kang, Hee Ju Kim, Ji Hyun Kwon, Young Mee Lee, Young Soo Seo, In Soo Kim
  • Patent number: 7879625
    Abstract: Improved surface-enhanced Raman scattering (SERS) substrates comprising chemically-derivatized magnetic microparticles complexed with metal colloidal particles or substrates. The SERS substrates permit collection, detection, measurement, and/or analysis of analytes present at concentrations ranging parts per trillion to parts per billion. Further, compositions, methods, and devices that provide for rapid and/or sensitive detection of chemical compounds of interest present in small concentrations. The subject matter has use in the areas of homeland security and force protection, for example, in the detection of trace samples including, for example, BTEX (benzene, toluene, ethylbenzene, and xylenes), chlorinated solvents, TNT, nerve agents, blister agents, metal ions, anions, antigens, peptides, nucleic acids, spores, fungi, viruses, and bacteria.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: February 1, 2011
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Pamela A. Boss
  • Publication number: 20110008525
    Abstract: Present embodiments are directed to a system and method for condensing and curing organic materials within a deposition chamber. Present embodiments may include condensing an organic component from a gas phase into a liquid phase on a target surface within the deposition chamber, wherein the gas phase of the organic component might be mixed with an inert gas. Further, present embodiments may include solidifying the liquid phase of the organic component into a solid phase within the deposition chamber using an inert plasma formed from the inert gas.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 13, 2011
    Applicant: General Electric Company
    Inventors: George Theodore Dalakos, Christian Maria Anton Heller, Ahmet Gun Erlat
  • Patent number: 7867782
    Abstract: Methods and structures for placing nanoscale moieties on substrates are provided.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: January 11, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Phillip W. Barth
  • Patent number: 7862849
    Abstract: A method of stamping of molecular patterns and/or devices based on the reversible self-assembly of molecules, particularly organic molecules is disclosed. This method is suitable for the stamping of almost any nanofabricated device and can be used to transferring a large amount of pattern information from one substrate to another at the same time.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: January 4, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Francesco Stellacci, Arum Amy Yu
  • Patent number: 7862859
    Abstract: A method of correcting for pattern run out in a desired pattern in directional deposition or etching comprising the steps of providing a test substrate; providing a stencil of known thickness on the test substrate; providing a stencil pattern extending through the stencil to the test substrate.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: January 4, 2011
    Assignee: RFMD (UK) Limited
    Inventor: Jason McMonagle
  • Patent number: 7863038
    Abstract: A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: January 4, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: Massoud Motamedi, Nicholas A. Kotov, James P. Wicksted, Rinat Esenaliev
  • Publication number: 20100330706
    Abstract: The present invention provides methods of making polymer-based biosensors and the biosensors made by said methods, wherein the biosensors comprise conducting polymers and negatively charged nanoparticles comprising a capture moiety. The present invention also provides methods of detecting analytes in a solution by contacting the solution with said polymer-based biosensors.
    Type: Application
    Filed: June 25, 2010
    Publication date: December 30, 2010
    Applicant: The Regents of the University of California
    Inventors: Fang Wei, Wei Liao
  • Patent number: 7858375
    Abstract: The present invention relates to methods for fabricating air-stable supported lipid bilayer membranes. In one embodiment, the present invention relates to methods of producing supported lipid bilayer membranes stabilized by sterol groups that are covalently tethered to a solid surface. In a further embodiment, the present invention relates to air-stable supported lipid bilayer membranes produced by the methods of the present invention.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: December 28, 2010
    Assignee: MicroSurfaces, Inc
    Inventors: Xiaoyang Zhu, Yang Deng, Yini Wang, David Barriet, Athena Guo
  • Patent number: 7851209
    Abstract: A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes conjugated probes that contain a specific binding member for the analyte of interest. The specific binding member preferentially complexes with the analyte within a test sample when contacted therewith. Excess analyte that remains uncomplexed with the specific binding member undergoes non-specific binding, such as to a hydrophobic domain. As a result, the ability of the uncomplexed analyte to compete with the complexed analyte at the detection zone of the device is restricted. Thus, the incidence of “false negatives” is limited in a simple, efficient, and relatively inexpensive manner.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: December 14, 2010
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ning Wei, Yanbin Huang, Kaiyuan Yang
  • Patent number: 7851028
    Abstract: Elongated molecules are stretched across a substrate by controlled fluid flow.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: December 14, 2010
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Lowell L. Wood, Jr.
  • Patent number: 7846748
    Abstract: The present invention provides methods of quantifying the amount or concentration of one or more peptides and/or proteins in one or more samples using differentially isotopically-labeled peptides and/or proteins. The invention also provides methods of identifying one or more peptides and/or proteins in one or more samples.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: December 7, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: Christoph H. Borchers
  • Patent number: 7829328
    Abstract: Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: November 9, 2010
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Kaiyuan Yang, Ning Wei, Rosann Kaylor, Chibueze Obinna Chidebelu-Eze, Zdravko Savov Atanassov
  • Publication number: 20100280601
    Abstract: The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 ??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 ??(IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 4, 2010
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Patent number: 7820227
    Abstract: A method for biolithographical deposition of molecules is provided. According to an embodiment of the method, a reactive layer (e.g., a polysaccharide mass) having a surface region coated with a biologically compatible resist is provided. A portion of the biologically compatible resist is selectively removed to expose an exposed portion of the reactive layer. Molecules, such as biomolecules and/or cellular species, are then conjugated to the exposed portion of the reactive layer. Also provided are materials and devices related to the method.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: October 26, 2010
    Assignees: University of Maryland, College Park, University of Maryland, Baltimore County
    Inventors: Gregory F. Payne, Gary W. Rubloff, Hyunmin Yi, Rohan Fernandes, Li-Qun Wu, Reza Ghodssi, William E. Bentley
  • Publication number: 20100254855
    Abstract: The present invention discloses a biochip comprising a substrate and a three-dimensional mesoporous layer on top of it, wherein the mesoporous layer on top is chemically modified to recognize labeling DNAs, proteins, peptides, saccharides, and cells. In addition, this invention also discloses a method for forming the biochip with a three-dimensional mesoporous layer, including a blending process, a heating process, a coating process, a gelation process, a drying process, and a surface modification process.
    Type: Application
    Filed: January 15, 2007
    Publication date: October 7, 2010
    Inventors: Yui-Whei Chen-Yang, Jui-Chuang Tzong-Yuan Wu, Yen-Kuang Li, Huan-Ching Yang
  • Patent number: 7794799
    Abstract: A method for manufacturing an array plate for biomolecules includes coating a surface of a substrate with a hydrophobic material to form a hydrophobic layer having initial hydrophobic properties, etching the hydrophobic layer through an etch mask placed thereon to form a hydrophilic binding site, removing the etch mask, and processing the remaining region of the hydrophobic layer to recover the initial hydrophobic properties. A method for manufacturing a biochip using this array plate, includes processing the surface of the hydrophilic binding site of the array plate to increase an affinity of biomolecules to the hydrophilic binding site, and applying a solution containing biomolecules to the surface of the hydrophilic binding site.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: September 14, 2010
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Woon-bae Kim, Chang-ho Cho, Kae-dong Back, Hwan-young Choi
  • Publication number: 20100221188
    Abstract: The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components. The surface coating may be a conformal polymeric film, permeable to the analyte, which may be deposited via a solventless process such as initiated chemical vapor deposition or photoinitiated chemical vapor deposition. The surface coating may increase the biocompatibility of the sensor, reduce nonspecific protein adsorption, and/or sequester functional sensor components within the sensor. The invention also provides methods for detecting the presence of an analyte with coated sensors of the invention.
    Type: Application
    Filed: September 8, 2009
    Publication date: September 2, 2010
    Applicants: The Charles Stark Draper Laboratory, Inc., Massachusetts Institute of Technology
    Inventors: Heather A. Clark, Karen K. Gleason, Salmaan Husain Baxamusa, John M. Dubach
  • Patent number: 7785649
    Abstract: Disclosed herein are a protein chip substrate and a method for manufacturing the protein chip substrate. The method includes deposition of plasma polymerized ethylenediamine (PPEDA) having an amine group on plasma polymerized cyclohexnane (PPCHex) by inductively coupled plasma-chemical vapor deposition (ICP-CVD), thereby preventing non-specific adsorption of proteins on a slide surface.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: August 31, 2010
    Assignee: Sungkyunkwan University Foundation for Corporate Collaboration
    Inventors: Dong-geun Jung, Sang-hak Yeo, Chang-rok Choi
  • Publication number: 20100203144
    Abstract: The present invention relates to compositions and methods by which surface modification techniques can be used to modify wide range polymeric or metal substrates using metal nanoparticles.
    Type: Application
    Filed: July 23, 2008
    Publication date: August 12, 2010
    Inventors: Cato T. Laurencin, Lakshmi Sreedharan Nair
  • Publication number: 20100196203
    Abstract: A method for forming a lipid bilayer across an aperture, comprises: (a) providing a cell having a chamber adjacent to a septum comprising a membrane having an aperture capable of supporting a lipid bilayer; (b) depositing one or more lipids on an internal surface of the chamber; (c) introducing an aqueous solution into the chamber to cover the aperture and the internal surface and to form an interface between the solution and lipids; and (d) moving the interface past the aperture at least once to form a lipid bilayer across the aperture.
    Type: Application
    Filed: February 18, 2008
    Publication date: August 5, 2010
    Inventors: Gurdial Singh Sanghera, Steven Paul White, Terence Alan Reid
  • Publication number: 20100159117
    Abstract: A guidewire having a super elastic core surrounded by a shape memory polymer jacket. The super elastic core wire permits the guidewire to be navigated through tortuous vasculature without undergoing plastic deformation, and the shape memory polymer jacket permits the guidewire to be shaped by the physician.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 24, 2010
    Inventors: Stephen Griffin, Ronald A. Sahatjian
  • Patent number: 7740896
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 22, 2010
    Assignee: Bayer Technology Services GmbH
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Patent number: 7722913
    Abstract: An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: May 25, 2010
    Assignee: Alfred E. Mann Foundation for Scientific Research
    Inventors: Joseph H. Schulman, Charles L. Byers, Gerald E. Adomian, Michael S. Colvin
  • Patent number: 7713750
    Abstract: A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predetermined pattern.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: May 11, 2010
    Assignee: The Johns Hopkins University
    Inventors: Jan Hoh, William F. Heinz