Implantable Permanent Prosthesis (i.e., Artificial Body Member) (e.g., Pacemaker, Lens, Cornea, Glaucoma Shunt, Heart Valve, Muscle, Spinal Disc, Breast, Internal Organ) Patents (Class 427/2.24)
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Patent number: 8282981Abstract: A system and method for coating an endoprosthesis involves an applicator capable of delivering a coating substance to the endoprosthesis without spraying. The applicator may have a tube or die through which a coating substance is moved upwards by capillary action or by means of a pump so as to form an accumulation of the coating substance at an upper portion of the applicator. The endoprosthesis can be lowered onto the accumulation, then axially translated or rotated in order to transfer the coating substance to selected portions of the endoprosthesis. The applicator is lowered and/or the endoprosthesis is raised in order to form gaps in the coating. Selective coating of abluminal or luminal surface of the endoprosthesis may also be performed by allowing the surface to skip on a liquid surface of a pool of the coating substance.Type: GrantFiled: June 24, 2008Date of Patent: October 9, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventor: Anthony S. Andreacchi
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Patent number: 8282979Abstract: An apparatus for coating medical devices at the point of care with a polymer and/or therapeutic agent comprising an environmentally controlled device coating chamber in which the device may be delivered by the manufacturer as the device packaging, or the device may be placed into the chamber at the point of care. The environmentally controlled chamber can provide a sterile enclosure in which the polymer and/or a therapeutic agent can be applied to an uncoated or previously coated device and converted to another form (such as a liquid to a film or gel) if desired, under controlled and reproducible conditions. The environmentally controlled chamber can accommodate and provide for coating the device by immersion, spray and other methods of covering the device surface with a liquid or powder. The chamber can provide for energy sources, both internally, such as heat produced by film heaters, and externally, such as UV light or microwave passing through the enclosure.Type: GrantFiled: August 3, 2010Date of Patent: October 9, 2012Inventors: Marian L. Larson, Eugene A. Larson
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Patent number: 8282982Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.Type: GrantFiled: October 1, 2008Date of Patent: October 9, 2012Assignee: Exogenesis CorporationInventors: Sean R. Kirkpatrick, Richard C. Svrluga
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Publication number: 20120252120Abstract: A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.Type: ApplicationFiled: May 24, 2012Publication date: October 4, 2012Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Amanda Murphy
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Patent number: 8277868Abstract: A drug delivery device for delivering therapeutic agents and a method of making such a device is disclosed. The device includes an inflatable balloon. A microporous coating covers a portion of the outer surface of the wall of the balloon. The thickness of the coating and the size of the micropores can permit desirable delivery of a substance from the micropores of the coating and into the tissue of a patient's lumen.Type: GrantFiled: December 18, 2009Date of Patent: October 2, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Lyudmila Kokish, Stephen D. Pacetti, John Stankus
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Publication number: 20120245685Abstract: Disclosed are an artificial breast implant in which the surface thereof is formed or modified with a silicone open cell (open pore) foam layer, and a method for producing the same. More specifically, disclosed are an artificial breast implant that has a surface including an open cell foam layer made of silicone and thus minimizes side effects such as in vivo rejection, which may occur after implantation of the implant into the body, in particular, the occurrence of capsular contracture to achieve superior biocompatibility and safety, and a method for producing the same.Type: ApplicationFiled: June 5, 2012Publication date: September 27, 2012Inventor: Won Seok Yu
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Patent number: 8273404Abstract: A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.Type: GrantFiled: May 19, 2008Date of Patent: September 25, 2012Inventors: Vipul Dave, Robert Falotico, Jonathon Z. Zhao
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Publication number: 20120237585Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.Type: ApplicationFiled: May 30, 2012Publication date: September 20, 2012Inventors: Omran R. Abul-Khoudoud, Catherine Cagiannos, Waldemar DeRijk, Timothy C. Fabian, Lisa Jennings
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Patent number: 8268381Abstract: A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at least two of the cyclic groups may include quaternary ammonium moieties. In some embodiments, a method may include applying a coating to a surface of a medical device. The coating may be antimicrobial. A coating may include antimicrobial bridged polycyclic compounds. In some embodiments, bridged polycyclic compounds may include quaternary ammonium compounds. In some embodiments, bridged polycyclic compounds may include guanidinium moieties. Bridged polycyclic compounds based coating systems may impart self-cleaning properties to a surface.Type: GrantFiled: May 2, 2007Date of Patent: September 18, 2012Assignee: AllAccem, Inc.Inventors: Jeffery A. Whiteford, William P. Freeman
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Patent number: 8268383Abstract: Medical implants exhibiting optimized mechanical properties, and methods of making such implants, are disclosed. That is, the implants are fabricated of a porous metal substrate and include coating integrated over various areas so as to provide some added or desirable property or functionality to the implant. In one embodiment, the implant is an acetabular implant with a coating applied to an internal, concave wear surface which is sized and configured to receive a head of a femur. Typically, the coating is a ceramic incorporated onto the desired area of the implant via electrophoretic deposition.Type: GrantFiled: August 24, 2009Date of Patent: September 18, 2012Assignee: Depuy Products, Inc.Inventor: Jason Langhorn
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Patent number: 8267990Abstract: Stents fabricated from hydrolytically degradable polymers with accelerated degradation rates and methods of fabricating stents with accelerated degradation rates are disclosed.Type: GrantFiled: August 31, 2010Date of Patent: September 18, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: David C. Gale, Bin Huang, Vincent Gueriguian, Syed Faiyaz Ahmed Hossainy
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Publication number: 20120231043Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: ApplicationFiled: March 9, 2012Publication date: September 13, 2012Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 8263171Abstract: The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.Type: GrantFiled: July 10, 2008Date of Patent: September 11, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: John T. Clarke, Timothy O'Connor
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Patent number: 8263170Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.Type: GrantFiled: January 6, 2010Date of Patent: September 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Ni Ding, Christopher Buchko
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Patent number: 8263169Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided.Type: GrantFiled: October 6, 2008Date of Patent: September 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Fuh-Wei Tang, Syed F. A. Hossainy, Dorie Happ, Ty T. Hu
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Patent number: 8257777Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.Type: GrantFiled: April 10, 2008Date of Patent: September 4, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Peter Edelman
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Publication number: 20120220934Abstract: An implant having a preferably hollow cylindrical main structure comprising a large number of continuous openings and a coating which releases at least one pharmaceutically active substance. To attain a better distribution of the pharmaceutically active substance, at least 20% of the cross-sectional area, preferably at least 50% of the cross-sectional area, of at least a portion of the openings in a predetermined section of the main structure is covered with the coating which releases at least one pharmaceutically active substance. Furthermore, a system composed of a catheter and such an implant, a simple method for manufacturing such an implant or such a system is provided.Type: ApplicationFiled: February 9, 2012Publication date: August 30, 2012Applicant: BIOTRONIK AGInventors: Tobias Diener, Elisabeta Burean, Matthias Fringes
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Publication number: 20120219529Abstract: The invention described herein relates to the preparation of silver compounds prepared from pectin and pectin derivatives and the process for preparing them. The silver derivatives thus prepared are amenable for use in the preparation of medical and/or veterinary dressings or implants.Type: ApplicationFiled: February 28, 2011Publication date: August 30, 2012Inventor: George H. Scherr
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Publication number: 20120219697Abstract: The present invention relates to methods of modifying the chemical structure of a surface by covalently attaching molecules containing desired functional groups on the surface using plasma energy. In these methods, chemical compounds containing the desired functional groups and having a vapor pressure lower than 0.001 bar are exposed in the plasma chamber together with the substrate. Surface area of the chemical compound is optimized to generate adequate evaporation rate. The modification of the substrate surface is achieved in a plasma state generated from the vapor of the chemical compounds; while the evaporation of the chemical compounds is accelerated by the plasma energy. Methods for producing non-fouling surface by covalently attaching ethylene glycol oligomers on the surface are disclosed.Type: ApplicationFiled: February 23, 2012Publication date: August 30, 2012Inventor: Xiaoxi Kevin Chen
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Patent number: 8252361Abstract: Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.Type: GrantFiled: November 28, 2007Date of Patent: August 28, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Pamela A. Kramer-Brown, Florian Ludwig
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Patent number: 8247019Abstract: The present invention provides an apparatus and a method for modifying a structure such as a medical device through the selective application of a coating. A coating sleeve may comprise an elastomeric wall that may be permeable or impermeable to a coating material and may be porous so as to allow for patterned coating of the device. The coating sleeve may contain surface protrusions that facilitate manipulation by providing sites for grasping and pulling. In operation the coating sleeve may be fitted on the device prior to application of a coating and removed subsequent to application of the coating.Type: GrantFiled: April 25, 2008Date of Patent: August 21, 2012Assignee: Harland Medical Systems, Inc.Inventors: Jonathan D. Anderson, Dale L. Anderson, Aaron J. Anderson
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Patent number: 8247020Abstract: Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold.Type: GrantFiled: May 14, 2010Date of Patent: August 21, 2012Assignee: Advanced Bio Prosthetic Surfaces, Ltd.Inventors: Daniel D. Sims, Jeffrey N. Steinmetz, Conor P. Mullens, Andrew Parker Wood, Christopher E. Banas
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Patent number: 8241698Abstract: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass.Type: GrantFiled: August 6, 2007Date of Patent: August 14, 2012Assignee: Massachusetts Institute of TechnologyInventors: Robert E. Cohen, Prem V. Pavoor, Anuj Bellare, Brian P. Gearing
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Publication number: 20120203338Abstract: An apparatus, system and method for coating an implantable lens. The apparatus, system and method may include at least one coating layer applied to at least one surface of the optic of the implantable lens, wherein the coating layer at least partially protects the optic at least during the implantation, and wherein the coating layer is removable following implantation. The coating layer may include a lubricant and/or medication and may be in the form of a biodegradable polymer and/or a film.Type: ApplicationFiled: February 3, 2011Publication date: August 9, 2012Applicant: Abbott Medical Optics Inc.Inventor: Rakhi Jain
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Patent number: 8236369Abstract: An apparatus and method for coating abluminal surface of a stent is described. A method for coating a stent can include stent mounting, stent movement, and droplet excitation. A method can include applying a coating to a stent, the applying including generating waves in a coating solution to eject droplets of the coating solution from a surface of the coating solution toward the stent, the generating performed by transducers submerged in the coating solution.Type: GrantFiled: July 20, 2010Date of Patent: August 7, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Yung Ming Chen
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Patent number: 8236368Abstract: The present invention relates to a method for preparing a hollow microneedle comprising preparing a solid microneedle by drawing lithography; plating the surface with a metal; removing the solid microneedle; and fabricating the hollow microneedle. The present invention ensures efficient preparation of a hollow microneedle with desired hardness, length, and diameter, and which may be effectively used for extracting internal analytical materials from the body and for drug injection.Type: GrantFiled: July 20, 2007Date of Patent: August 7, 2012Assignee: Industry-Academic Cooperation Foundation, Yonsei UniversityInventors: Hyung Il Jung, Kwang Lee
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Patent number: 8231929Abstract: Methods for coating medical devices for implantation within a body vessel are provided comprising providing a cylindrical container, placing a medical device inside the cylindrical container, and applying a polymer in liquid form inside the container.Type: GrantFiled: October 23, 2007Date of Patent: July 31, 2012Assignee: Cook Medical Technologies LLCInventor: Jichao Sun
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Patent number: 8231930Abstract: An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.Type: GrantFiled: August 4, 2009Date of Patent: July 31, 2012Assignee: Maquet Cardiovascular, LLCInventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
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Publication number: 20120190114Abstract: A silicon-incorporated diamond-like carbon thin film, a fabrication method thereof, and its use are disclosed. The silicon-incorporated diamond-like carbon thin film comprises a chemical bond between carbon and silicon atoms present on a surface of the silicon-incorporated diamond-like carbon thin film comprising silicon incorporated within and on the surface thereof with an atom providing hydrophilicity to the surface of the thin film on the surface of the thin film.Type: ApplicationFiled: October 8, 2009Publication date: July 26, 2012Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Myoung-Woon Moon, Kwang Ryeol Lee, Jin Woo Yin, Hae-Ri Kim
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Patent number: 8227016Abstract: The present invention provides a method of applying a drug-polymer coating on a stent. A stent framework is dipped into a first polymeric solution including a first polymer, a first therapeutic agent, and a first solvent. The polymeric solution is dried and the first polymer is cured to form a thin drug-polymer layer on the stent framework. The steps of dipping the stent framework into the first polymeric solution, drying the first polymeric solution, and curing the first polymer are repeated until a target drug-polymer coating thickness is disposed on the stent framework. A drug-polymer coated stent including a stent framework and a laminated drug-polymer coated stent, a system for treating a vascular condition, and a method of treating a vascular condition are also disclosed.Type: GrantFiled: May 18, 2010Date of Patent: July 24, 2012Assignee: Medtronic Vascular, Inc.Inventors: Ronan Thornton, Finbar Dolan
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Patent number: 8227018Abstract: A method of manufacturing a dental post according to the present invention comprises the steps of: (i) overjacketing extrusion of at least one thermoplastic material over at least one filament or yarn, such that the thermoplastic material cross-sectionally enwraps the at least one filament or yarn; (ii) solidifying the extruded product of step (i); (iii) equipping the solidified extruded product of step (ii) with a surface texture, such that the thermoplastic wrapping is not modified in a way as to expose or damage the at least one filament or yarn. The invention allows for more flexibility in the manufacturing of dental posts, especially in generating surface textures of such dental posts.Type: GrantFiled: October 2, 2008Date of Patent: July 24, 2012Assignee: Coltene Whaledent AGInventors: Werner Mannschedel, Ralf Bohner, Barbara Muller
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Patent number: 8227017Abstract: A system and method of enhancing the antimicrobial and biofilm-resistant efficacy of surfaces that have cationic polyelectrolytes nonleachably bound thereto in order to impart antimicrobial activity to the surface. The system for enhancing antimicrobial efficacy involves brushing, dipping, wiping, spraying, or storing the surface in a solution containing citrate ion. The method involves treatment of the surface with a solution which enhances the antimicrobial and biofilm-resistant efficacy of the surface, and which prevents a loss of the antimicrobial properties of the surface which may occur over time. Preferably, the enhancement agent is citrate ion and the cationic polyelectrolyte is poly(diallyldimethylammonium chloride), also known as polyDADMAC. The system is particularly beneficial for surfaces of articles such as contact lenses.Type: GrantFiled: November 13, 2008Date of Patent: July 24, 2012Assignee: Quick-Med Technologies, Inc.Inventors: Susan Leander, William Toreki, Gerald Olderman, Albina Mikhaylova
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Publication number: 20120185037Abstract: The invention relates to methods and apparatus for manufacturing implantable medical devices, such as intravascular stents, wherein the medical device has a surface treated to promote the migration of endothelial cells onto the surface of the medical device. In particular, the surface of the medical device has at least one groove formed therein, the at least one groove may have a drug-eluting polymer disposed therein or a drug-eluting polymer coating may be provided on the surface of the medical device and grooves formed in the drug eluting polymer coating.Type: ApplicationFiled: August 19, 2011Publication date: July 19, 2012Applicant: Palmaz Scientific, Inc.Inventor: Julio C. Palmaz
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Publication number: 20120183583Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.Type: ApplicationFiled: January 6, 2012Publication date: July 19, 2012Inventors: Joshua Stopek, Amin Elachchabi, Daniel Broom
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Publication number: 20120183782Abstract: The present disclosure relates to implants with a biocompatible coating having antithrombogenic properties and which also contains a pharmacologically active agent, as well as a process for their production.Type: ApplicationFiled: August 17, 2011Publication date: July 19, 2012Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Olaf Fritz, Ulf Fritz, Stefan Nagel, Michael Boxberger
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Patent number: 8221823Abstract: A diamond-like carbon film (DLC film) is formed on the surface of a base material made of an inorganic material, such as ceramics, or the like, or an organic material, such as resin, or the like. The surface of the resultant DLC film is treated with plasma, or the like, so as to be activated. Various monomers having biocompatibility, etc., are graft-polymerized to the activated surface of the DLC film, whereby a polymer layer is formed from the monomers grafted to the surface of the DLC film. Thus, the base material coated with the DLC film modified with a polymer which does not readily separate can be realized.Type: GrantFiled: February 1, 2010Date of Patent: July 17, 2012Assignee: Toyo Advanced Technologies Co., Ltd.Inventors: Yoshinori Abe, Tatsuyuki Nakatani, Keishi Okamoto, Kohei Shiraishi, Kazuo Sugiyama
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Patent number: 8221504Abstract: A method of preparing an implant for bone in-growth comprising: providing a metal implant body, the metal implant body having a metal load bearing layer on an outer surface, the metal load bearing layer having a plurality of pores therein, the pores configured to promote bone in-growth into the load bearing layer; providing calcium sulfate hemi-hydrate; providing a diluent; mixing the calcium sulfate hemi-hydrate and the diluent to form a calcium sulfate paste; applying the calcium sulfate paste to the load bearing layer such that the calcium paste substantially impregnates at least a portion of the pores and forms an excess layer of the calcium sulfate paste on an outer surface of the load bearing layer; and wiping the calcium sulfate paste to remove the excess layer and thereby expose the outer surface of the load bearing layer while leaving the calcium sulfate paste impregnated in the pores.Type: GrantFiled: February 23, 2005Date of Patent: July 17, 2012Assignee: Wright Medical Technology, Inc.Inventors: Kelly C. Richelsoph, Linda Morris, Jantzen A. Cole
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Patent number: 8221822Abstract: Methods for making medical devices having porous coatings. Methods may comprise providing a tubing section having inner and outer surfaces and positioning a nozzle proximate to a target surface of the parent tubing section. A powder form of the porous coating may be delivered toward the tubing section, and a laser may be directed at the powder to melt the powder to form a melt pool. The melt pool can solidify to form the porous coating on the target surface. Portions of the parent tubing section may then be cut away to form the support structure of the medical device, such as a stent.Type: GrantFiled: July 30, 2008Date of Patent: July 17, 2012Assignee: Boston Scientific SciMed, Inc.Inventors: Aiden Flanagan, Tim O'Connor
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Patent number: 8221821Abstract: The present invention provides a method of manufacturing a stent having a coating, comprising providing a tubular stent having a lumenal side and an ablumenal side; applying a coating composition to the stents such that the coating composition contacts the lumenal and ablumenal sides of the stent; and modifying the diameter of the stent from a first diameter to a second diameter during the process of applying the coating composition.Type: GrantFiled: November 9, 2007Date of Patent: July 17, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Lisa Weldon, Stephen Pacetti
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Publication number: 20120179237Abstract: A spray system and method of using such spray system to fabricate a polymer membrane structure for use as a vascular graft or tissue engineered scaffold is provided. Generally, this spray system includes the use of at least two spray apparatus to apply different polymer and solvent mixtures to the outer surface of a mandrel to form a blended layer. Upon curing of the blended layer, phase separation occurs leading to the formation of a polymer membrane structure having variable properties along at least a portion of its longitudinal axis.Type: ApplicationFiled: January 12, 2011Publication date: July 12, 2012Inventors: Keith R. Milner, Matthew S. Huser
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Patent number: 8216630Abstract: The present invention relates to a porous biomaterials surface activation method by coating with a layer of apatitic nanocrystals in order to increase their surface reactivity. The method according to the invention is characterized by the following steps: a) preparing a nanocrystalline apatitic calcium phosphate analogous to bone mineral by mixing a calcium salt solution with a phosphate salt solution in a Ca/P ratio ranging between 1.3 and 2 at a temperature ranging between 0 and 60 ° C., b) slurrying the mixture obtained in step a) in an aqueous solution so as to obtain a fluid, homogeneous paste containing 80 to 98% of water, c) bringing a porous biomaterial into contact with the suspension obtained in step b), d) drying the porous biomaterial at a temperature below 100 ° C.Type: GrantFiled: June 18, 2009Date of Patent: July 10, 2012Assignees: Institut National Polytechnique de Toulouse, TEKNIMEDInventors: Hélène Autefage, Sophie Cazalbou, Christèle Combes, Christian Rey
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Patent number: 8216629Abstract: This invention relates to a method of making an intraocular lens insertion device comprising a lubricious insertion tip assembly and to the device itself.Type: GrantFiled: October 29, 2007Date of Patent: July 10, 2012Assignee: Advanced Vision Science, Inc.Inventor: Khalid Mentak
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Patent number: 8216631Abstract: A cardiac valve prosthesis having a frame and two or more leaflets (preferably three) attached to the frame. The leaflets are attached to the frame between posts, with a free edge which can seal the leaflets together when the valve is closed under back pressure. The leaflets are created in a mathematically defined shape allowing good wash-out of the whole leaflet orifice, including the area close to the frame posts, thereby relieving the problem of thrombus deposition under clinical implant conditions.Type: GrantFiled: November 4, 2010Date of Patent: July 10, 2012Assignee: Aortech International PLCInventors: Bernard O'Connor, David John Wheatley, Gillian Maureen Bernacca, William Stafford Haworth
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Publication number: 20120171354Abstract: The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device.Type: ApplicationFiled: December 9, 2011Publication date: July 5, 2012Applicant: EnBIO LimitedInventors: Liam O'Neill, John O'Donoghue
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Publication number: 20120171353Abstract: A method of coating a medical prosthesis includes identifying coating points on the surface of the medical prosthesis and determining a coating pathway along which an applicator travels while coating the medical prosthesis. In some embodiments, the coating pathway minimizes the rotational movement of the medical prosthesis during the coating process. In other embodiments, the coating pathway minimizes the amount of time needed for the coating process.Type: ApplicationFiled: September 23, 2011Publication date: July 5, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Gareth Walsh
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Patent number: 8214032Abstract: An implantable biocompatible device, that may be either a sensor or stimulator, having electronic circuitry and electrodes formed on a substrate, is uniformly covered with a coating approximately one-micron thick of ultra-nanocrystalline diamond, hermetically sealing the electronic circuitry. Selected electrodes are either left uncovered during coating or uncovered by conventional patterning techniques, allowing the electrodes to be exposed to living tissue and fluids. The ultra-nanocrystalline diamond coating may be doped to create electrically conductive electrodes. These approaches eliminate the need for a hermetically sealed lid or cover to protect hybrid electronic circuitry, and thus allow the device to be thinner than otherwise possible. The conformal ultra-nanocrystalline diamond coating uniformly covers the device, providing relief from sharp edges and producing a strong, uniformly thick hermetic coating around sharp edges and on high aspect-ratio parts.Type: GrantFiled: June 12, 2006Date of Patent: July 3, 2012Assignee: Second Sight Medical Products, Inc.Inventors: Brian V. Mech, Robert J. Greenberg
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Patent number: 8211489Abstract: Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to a material delivery apparatus. A spray pattern of an application material is produced using the material delivery apparatus. At least a portion of the spray pattern is deflected using a focusing assembly.Type: GrantFiled: December 9, 2008Date of Patent: July 3, 2012Assignee: Abbott Cardiovascular Systems, Inc.Inventor: Stephen Pacetti
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Publication number: 20120165937Abstract: The present invention relates to a prosthetic fabric comprising an arrangement of yarns defining at least two faces for said fabric, said fabric comprising, on at least one of its faces, one or more barbs that protrude outwards relative to said face, characterized in that said barbs are covered with a coating made of a water-soluble biocompatible material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric.Type: ApplicationFiled: September 6, 2010Publication date: June 28, 2012Applicant: SOFRADIM PRODUCTIONInventors: Suzelei Montanari, Pearl Rey
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Publication number: 20120164310Abstract: A device for coating a medical implant includes a container that contains a liquid having at least one pharmaceutically active substance. An elastic head for application of the liquid onto a surface to be coated is connected to an inside of the container through at least one channel.Type: ApplicationFiled: December 21, 2011Publication date: June 28, 2012Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Hubert BÜCHNER
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Publication number: 20120164309Abstract: A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.Type: ApplicationFiled: December 20, 2011Publication date: June 28, 2012Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Klaus-Dieter KÜHN