Abstract: Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.

Abstract: A liposome comprising a region of a lipid bilayer membrane with different membrane thicknesses, wherein each lipid bilayer membrane region is composed of a different lipid, and a thick membrane side in the region of the lipid bilayer membrane is formed of lipid having a phase transition temperature higher than that of the lipid forming a thin membrane side in the region of the lipid bilayer membrane. A proteoliposome, wherein the above-described liposome includes membrane proteins. A biochip, wherein the above-described liposome or the above-described proteoliposome is spread on a substrate. The above-described biochip, wherein the substrate includes at least one kind selected from the group consisting of mica, SiO2, SiN, Au and Pt.

Abstract: Stock materials for manual and/or high speed industrial automated bonding applications having a curable pre-applied adhesive or sealant compositions on the bonding surfaces wherein the curative for the pre-applied adhesive or sealant composition is contained within a carrier which prevents its premature release.

Abstract: Certain diacylglycerol-polyethyleneglycol (DAG-PEG) lipids are especially useful for forming thermodynamically stable liposomes. Such liposomes are useful for a variety of purposes, including the delivery of therapeutic agents.

Abstract: The present invention aims to provide a seamless capsule free of an interfacial tension modifier and a gelling agent. The present invention provides a shell formed by a shell composition containing gelatin and a plasticizer, but free of an interfacial tension modifier and a gelling agent, and a seamless capsule comprising a capsule content free of an interfacial tension modifier and a gelling agent.

Abstract: A fixing solution for fixing toner to a recording medium, includes aliphatic ester held by solvent in a soluble manner, and having solubility or swelling property with respect to resin included in the toner.

Abstract: An adhesive material (B) is provided which includes a plurality of (micro)capsules (1) each including: a waterproof outer wall (2) capable of being crushed by an external force; a moisture-curing adhesive (3) encapsulated with the outer wall (2); and a tackiness agent coat (4) formed over an outer surface of the outer wall (2).

Abstract: A flame-resistant microcapsule that comprises a core comprising a phase change material and a wall material encapsulating the core. The microcapsules includes at least one of: a flame retardant applied to the wall material and a phase change material having a boiling point of about 230° C. to about 420° C. to provided enhanced flame resistance. The phase change material may have a boiling point of about 280° C. to about 400° C. or about 300° C. to about 390° C.

Abstract: The present invention relates to a method for stabilizing enzyme and water- and oil-soluble active components using polyol/polymer microcapsules, and to a cosmetic composition containing the enzyme and the microcapsules. More particularly, the present invention relates to polyol/polymer microcapsules which effectively stabilize the enzyme and active components, which are unstable in the formulations, through increasing the solubility thereof in hydrophobic polymer by using polyol, and to a method for preparing the polyol/polymer microcapsules.

Abstract: A reinforced composite material includes a solid polymer matrix, a reinforcing material in the solid polymer matrix, and a first plurality of capsules. The reinforcing material includes a surface. The capsules are on the surface of the reinforcing material, and include a liquid healing agent. The amount of the healing agent of the capsules is at least 0.01 milligrams per square centimeter of the surface area of the reinforcing material.

Abstract: A method for producing a molecular compound which comprises mixing and kneading a solid host compound and a solid or liquid guest compound by using a kneader and optionally followed by extruding and granulating, wherein the method further comprises one or more of the steps of holding the product at a temperature which is 50° C. or higher and not higher than the emission temperature for the guest compound, washing the formed molecular compound with a solvent capable of dissolving the guest compound, pulverizing in advance the solid host compound, and adding a poor solvent such as water prior to mixing and kneading. The method allows the production of a molecular compound having improved stability.

Abstract: Agglomerating carrier materials in the presence of a granulation liquid with a carbohydrate content and subsequent incorporation of a liquid, such as a perfume oil, yields fluid-containing particles that, even at an elevated liquid loading, exhibit very good powder properties and reliably retain the incorporated liquid even in aggressive solid matrices. These fluid-containing particles may be used, for example, for fragrancing purposes.

Abstract: The microcapsules for electrophoretic display devices according to the present invention each enclose a dispersion containing electrophoretic particles and a solvent in a shell having an inner shell made of a mercapto group-containing amino resin and an outer shell made of an epoxy resin. Alternatively, the microcapsules for electrophoretic display devices according to the present invention each have a capsule strength of 0.6 MPa or higher. These microcapsules are produced by dispersing a dispersion containing electrophoretic particles and a solvent as a core substance in a water-based medium, and subsequently forming at least one shell on the surface of the core substance. These microcapsules can be used, as their applications, for sheets for electrophoretic display devices, electrophoretic display devices using the sheets, and electronic equipments using the electrophoretic display devices.

Abstract: A method of making core-shell capsules containing a water-immiscible liquid, comprising the steps of (a) dispersing into the water-immiscible liquid a crosslinking agent that is inactive under the conditions of the dispersion; (b) emulsifying the resulting dispersion into an aqueous solution of a crosslinkable hydrocolloid; and (c) activating the crosslinking agent to cause the hydrocolloid to crosslink at the dispersion/solution interface. The method is simple and provides capsules that can be cold-loaded.

Abstract: A microcapsule comprising a core containing a hydrophobic liquid or wax and a polymeric shell formed from: i) 1 to 20% by weight of polymerisable silane compound, ii) 1 to 94% by weight of hydrophobic mono functional ethylenically unsaturated monomer, iii) 5 to 98% by weight of polyfunctional ethylenically unsaturated monomer, and iv) 0 to 60% by weight of other mono functional monomer(s), wherein components (i), (ii), (iii) and (iv) total 100%, and in which the microcapsule also includes a hydrophilic polymer which is covalently bonded to the microcapsule. The invention includes a process for the manufacture of particles and the use of particles in articles, such as fabrics, and coating compositions, especially for textiles.

Abstract: The present invention describes a process of preparing microcapsules in a UV curable water immiscible phase. The microcapsules formed according to the invention contain an aqueous phase core. The process comprises dispersing a water soluble or dispersible core material along with at least one wall forming prepolymer and a polycondensation polymerization catalyst into an aqueous solution. The aqueous phase is then dispersed into the water immiscible phase comprising UV curable monomers or oligomers forming droplets of the aqueous phase solution in the water immiscible phase. Polycondensation of the prepolymers is initiated to form polymeric wall material or microcapsules at or near the interface of the water immiscible solvent and droplets of aqueous phase solution. Following capsule formation, a UV initiator is dispersed in the water immiscible phase. The UV curable dispersion containing aqueous microcapsules can be coated on a substrate.

Abstract: The present invention relates to aminoplast-membrane single-core or multi-core microcapsules whose core is comprised of at least two organic and/or inorganic compounds. The invention also relates to methods of preparing said microcapsules.

Abstract: Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.

Abstract: Described is a method for obtaining hollow particles, having a particle wall and a particle lumen, the particle having dimensions of between 1 nm and 100 ?m, from a mixture comprising a liquid medium comprising at least one colloid or solute, the method comprising freezing said mixture and lyophilising the obtained frozen mixture, characterised in that a volume of at least 0.1 ?l of the mixture is subjected to a freezing step comprising: (a) (1) quench freezing the mixture resulting in a quench frozen mixture, and (2) incubating said quench frozen mixture at a temperature above the quench freezing temperature and below the melting point of the liquid medium, orb) (1) reducing the temperature of the mixture at a rate of 1 to 100° C./minute to below the freezing temperature of the mixture and (2) incubating said frozen mixture at a temperature above the temperature of the mixture and below the melting point of the liquid medium.

Abstract: Amorphous particles are provided comprising a homogeneous distribution of one or more dyes encapsulated by an amorphous, siliceous encapsulating agent, wherein the amorphous particle comprises from 3% to 20% dye, by weight of the particle.

Abstract: Particles that are encapsulated by protein are provided. Also a method for preparing protein encapsulated particles involving spraying and drying of an activated protein solution is provided. The protein encapsulated particles are particularly suited for food, feed, cosmetic and pharma applications.

Abstract: This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use.

Abstract: A method of separating vesicles whose membrane has been modified with a hydrophilic polymer (polyethylene glycol, etc.). In the method, vesicles (liposome, etc.) differing in the degree of membrane modification are separated by ion-exchange chromatography using a concentration gradient in which the ionic intensity of an eluent is changed with time. Also provided are: a process for producing vesicles purified so as to have a desired degree of modification with a hydrophilic polymer which comprises utilizing the separation method in the step of purifying vesicles; a method of evaluating a medicinal vesicle preparation containing a drug therein, the method comprising using the separation method; and vesicles in which the membrane has been modified with a hydrophilic polymer and which include no vesicle having a degree of membrane modification less than 0.5 mol %.

Abstract: A polishing pad is provided. The polishing pad includes a polishing layer composed of a polymeric matrix and liquid microelements embedded in the polymeric matrix. Open pores defined by the embedded liquid microelements are distributed across a surface of the polishing layer. Due to the microstructural open pores uniformly distributed across a surface of the polishing pad, a polishing operation can be performed at high precision. The polishing pad shows constant polishing performance during the polishing operation, can be stably used, and does not cause a wafer to be scratched. In addition, a method of manufacturing the polishing pad is provided. Since all components used to manufacture the polishing pad are in a liquid phase, manufacturing can be easily performed.

Abstract: A method of making microcapsules including activating a fluid ejector at a frequency greater than 10 kilohertz where each activation of the fluid ejector generates essentially a drop, and the fluid ejector is fluidically coupled to a first fluid including a core component. The method further includes ejecting the drop of the first fluid into a second fluid, the drop having a volume. In addition, the method includes generating a microcapsule, that includes the core component, in the second fluid for each drop of the first fluid ejected.

Abstract: Cellulosic fibers having enhanced reversible thermal properties and applications of such cellulosic fibers are described. In one embodiment, a cellulosic fiber includes a fiber body including a cellulosic material and a set of microcapsules dispersed in the cellulosic material. The set of microcapsules contain a phase change material having a latent heat of at least 40 J/g and a transition temperature in the range of 0° C. to 100° C., and the phase change material provides thermal regulation based on at least one of absorption and release of the latent heat at the transition temperature. The cellulosic fiber can be formed via a solution spinning process, and can be used in various products where thermal regulating properties are desired.

Abstract: An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid having an inner surface contained within the outer surface of the outer droplet of the first liquid, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the inner surface of the inner droplet. The block copolymers include a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize the droplet structure, and the first liquid is immiscible in the substantially continuous liquid medium.

Abstract: Inorganic compound particles constituted of a shell, a porous matter or a cavity enclosed therein, and the porous matter or the cavity being kept unchanged in a subsequently formed transparent coating film.

Abstract: Dry liquids having a particle size distribution (cumulative undersize) D10% ?80 to 140 ?m D50% 140 to 200 ?m D90% 190 to 340 ?m are prepared by passing the liquids and a hydrophobic, pyrogenically prepared silica through a clearly defined, spatially limited shear zone in which the liquids are broken up into small droplets and are surrounded by the hydrophobic, pyrogenically prepared silica.

Abstract: Colloidosomes having tunable properties, methods for making the same, and applications thereof are described. Colloidosomes described herein are responsive to certain external stimulus to alter one or more properties of the colloidosome. Methods for making colloidosomes include forming a shell of colloidal particles on a core material where the colloidal particles and the core material have attractive interactions.

Abstract: Thermo-expansive microcapsule comprising: a polymeric shell produced by polymerizing 15 to 75 weight % of a nitrile monomer, 10 to 65 weight % of a monomer having a carboxyl group, 0.1 to 20 weight % of a monomer having an amide group and 0.1 to 20 weight % of a monomer having a cyclic structure in its side chain; and a blowing agent encapsulated in the polymeric shell.

Abstract: A multi-capsule composition includes a first capsule, which includes a first capsule wall defining a first interior volume and a first fluid in the first interior volume, and a plurality of second capsules, at least partially embedded in the first capsule wall. The second capsules include a second capsule wall defining a second interior volume and a second fluid in the second interior volume. The multi-capsule composition may include at least one active agent, such as pharmaceutical agents, food additives, cleaning agents, complexing agents, personal care substances, lubricants, adhesives, heating/cooling agents, colorants, indicators, superabsorbents, agricultural additives, and healing agents.

Abstract: The present invention relates to microencapsulated compositions of isothiazolone derivatives and other water insoluble biocides or antifouling agents. In particular, the present invention relates to microencapsulated 4,5 dichloro 2 n-octyl-3(2H)-isothiazolone(DCOIT), useful in marine antifouling coatings and paints.

Abstract: When being blended in a toner, a barium titanate external additive for toner enhances, in particular, the toner fluidity, electrical properties, and other relevant performance; concurrently achieves high image density and reduced background fog in a printer using the toner; and further reduces image defects, such as void, fading, and the like. An industrially advantageous producing method of the barium titanate external additive for toner is also provided. The external additive for toner of the present invention includes spherical barium titanate having a specific gravity of 5.6 g/ml or less.

Abstract: The present invention relates to a film-forming composition for hard capsules comprising fish gelatin and its preparation method, and more particularly to a film-forming composition for hard capsules comprising fish gelatin using transglutaminase, the composition being able to be dried at 15 -25° C., and its preparation method. In the present invention, the problems caused due to the characteristics of fish gelatin having a low gelling temperature were solved by employing transglutaminase in the preparation of hard capsules using fish gelatin. Accordingly, the composition according to the present invention, its preparation method and the hard capsules and films comprising the composition may be useful to apply to a variety of industrial fields such as medicines, foods, etc.

Abstract: The present invention relates to whey protein micelles, particularly to whey protein micelle concentrates or powders thereof and to a method for producing them. The present invention also pertains to the use of these micelles concentrates or powders thereof in nutrition and/or cosmetics and/or pharmaceutics.

Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.

Abstract: Disclosed are compositions and methods related to clot binding compounds. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

Abstract: Microencapsulated delivery vehicles comprising an active agent are disclosed. In one embodiment, the microencapsulated delivery vehicles are heat delivery vehicles capable of generating heat upon activation. The microencapsulated heat delivery vehicles may be introduced into wet wipes such that, upon activation, the wet wipe solution is warmed resulting in a warm sensation on a user's skin. Any number of other active ingredients, such as cooling agents and biocides, can also be incorporated into a microencapsulated delivery vehicle.

Abstract: A stabilized emulsion is employed to produce shelf stable, controlled release, discrete, solid particles or pellets which contain an encapsulated and/or embedded component, such as a readily oxidizable component, such as omega-3 fatty acids. An oil encapsulant component which contains an active, sensitive encapsulant, dissolved and/or dispersed in an oil is admixed with an aqueous component and a film-forming component to form an emulsion. An antioxidant for prevention of oxidation of the active, sensitive encapsulant, and a film-softening component or plasticizer for the film-forming component may be included in the emulsion. The emulsion is stabilized by subjecting it to homogenization. The pellets are produced by first reducing the water content of the stabilized emulsion so that the film-forming component forms a film around the oil droplets and encapsulates the encapsulant. In embodiments of the invention, the water content of the homogenized emulsion may be reduced by spray-drying to produce a powder.

Abstract: A substrate care product, such as a fabric conditioner, that provides to the substrate a primary benefit (such as fabric conditioning) and at least one secondary benefit thereto (such as fragrance), the secondary benefit being provided by at least one encapsulated volatile substance that is encapsulated in a capsule having a hydrogel shell and an oily core, the volatile substance having been loaded to blank capsules in the presence of water. The product is storage-stable, and the secondary benefit especially long-lasting.

Abstract: The present invention generally relates to systems and methods for forming fluidic droplets comprising particles such as colloidal particles, which may be distributed on the surfaces of the fluidic droplets in some cases, thereby encapsulating the fluidic droplets. The particles at least partially surrounding the fluidic droplet may be colloidal particles in some cases, i.e., forming a “colloidal capsule.” In one set of embodiments, the particles may be positioned on the surface of a fluidic droplet such that the fluidic droplet is able to maintain a shape that, when left undisturbed, is not achievable by an undisturbed fluidic droplet free of discrete particles, for example, elongated or prolate ellipsoid fluidic droplets. Such fluidic droplets may also exhibit unusual properties, for example, plasticity, isolation from electromagnetic fields, certain electrical and/or magnetic properties, and/or mechanical resistance.

Abstract: The present invention concerns novel methods of identifying peptide sequences that selectively bind to targets. In alternative embodiments, targets may comprise cells or clumps of cells, particles attached to chemicals compounds, molecules or aggregates, or parasites. In preferred embodiments, target cells are sorted before exposure to the phage library. The general method, Biopanning and Rapid Analysis of Selective Interactive Ligands (BRASIL) provides for rapid and efficient separation of phage that bind to targets, while preserving unbound phage. BRASIL may be used in preselection procedure to subtract phage that bind non-specifically to a first target before exposing the subtracted library to a second target. Certain embodiments concern targeting peptides identified by BRASIL and methods of use of such peptides for targeted delivery of therapeutic agents or imaging agents or diagnosis or treatment of diseases.

Abstract: A self-healing coating, incorporating medium-sized microcapsules filled with a liquid formulation, repairs itself upon physical compromise. In one embodiment, a commercial primer is mixed with these microcapsules and applied. After the coating has cured, any physical compromise of the cured coating results in the microcapsules bursting to release the liquid, in turn filling and sealing the compromised volume of the coating. In applications where a product is used to provide corrosion protection, the liquid contains anti-corrosion material as well as suitable diluents and film-forming compounds. In a preferred embodiment, the microcapsules are provided separately to be mixed with commercial products during preparation for application of the coating. For example, if a paint formulation is known a priori, tailored microcapsules packaged separately from the paint and designed for use with the paint formulation, are wet mixed into the paint during preparation for application.

Abstract: A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.

Abstract: The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

Abstract: The present invention relates to blends of encapsulated biocides with free biocides. In particular, the present invention relates to blends of encapsulated 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone (“DCOIT”) with free biocides. The invention also relates to marine antifouling coatings and paints incorporating free biocides and encapsulated DCOIT, and using the free biocides and encapsulated DCOIT in marine antifouling coatings and paints.

Abstract: A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.

Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.

Abstract: Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.