Containing Two Or More Hetero Rings Patents (Class 435/118)
  • Patent number: 9441254
    Abstract: The present invention is directed to processes for preparing an intermediate for a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: September 13, 2016
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Fred Fleitz, Ian Mangion, Jingjun Yin
  • Patent number: 9097692
    Abstract: The invention relates to a method for quantitatively determining impurities in the form of aldehydes and ketones in glycerin serving for preparing pharmaceuticals, in which the glycerin containing impurities is reacted with a derivatization reagent in a sample solution and the quantity of derivatized impurities is determined. Said method is characterized in that PFBHA, O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride, is used as the derivatization reagent, the derivatizing is conducted in the presence of a solubilizer in the form of a polar organic solvent, and liquid chromatographic separation and UV detection are performed. A subject matter of the invention is also the use of glycerin, in which the content of impurities of 9 ppm or less has been determined by means of the described method in a pharmaceutical preparation. According to the invention, impurities in glycerin can be better determined.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: August 4, 2015
    Assignee: Aug. Hedinger GmbH & Co. KG
    Inventors: Frank Milek, Rouven Josl
  • Publication number: 20150147789
    Abstract: Methods for producing biliverdin in a microorganism, methods for producing biliverdin from a non-animal source, cells for producing biliverdin and methods for producing cells for producing biliverdin are disclosed.
    Type: Application
    Filed: February 3, 2015
    Publication date: May 28, 2015
    Applicant: UTAH STATE UNIVERSITY
    Inventors: Jon Y. Takemoto, Dong Chen
  • Publication number: 20150099880
    Abstract: The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
    Type: Application
    Filed: May 17, 2013
    Publication date: April 9, 2015
    Applicant: Genetech, Inc.
    Inventors: Srinivasan Babu, Francis Gosselin, Yingqing Ran, Travis Remarchuk, Scott J. Savage, Jeffrey Stults, Herbert Yajima
  • Publication number: 20150093793
    Abstract: The present invention relates to a novel method for producing metabolites from omeprazole using bacterial cytochrome P450, and a composition therefor, and more specifically, to a composition and a kit for producing a 5?-hydroxyl product from omeprazole, containing bacterial cytochrome P450 BM3 (CYP102A1) or mutants thereof, and to a method for producing the same. The composition, the kit, and the method are capable of economically and highly efficiently mass-producing the 5?-hydroxyl product from the omeprazole, and thus will significantly contribute to development of a novel drug using metabolites from the omeprazole.
    Type: Application
    Filed: December 21, 2012
    Publication date: April 2, 2015
    Inventor: Chul-Ho YUN
  • Patent number: 8980586
    Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 17, 2015
    Assignees: The Ritsumeikan Trust, National University Corporation Shizuoka University
    Inventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
  • Patent number: 8980585
    Abstract: Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified strains. Novel genes allowing biosynthesis of allylmalonyl-CoA can be used for polyketide production with allylmalonyl extender unit.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: March 17, 2015
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Hrvoje Petkovic, Enej Kuscer, Stefan Fujs, Gregor Kopitar, Peter Mrak, Gregor Kosec
  • Publication number: 20150056668
    Abstract: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Inventors: Yong Koy Bong, Michael D. Clay, Steven J. Collier, Benjamin Mijts, Michael Vogel, Xiyun Zhang, Jun Zhu, Jovana Nazor, Derek J. Smith, Shiwei Song
  • Patent number: 8883461
    Abstract: The present invention discloses a process for producing purple-blue natural pigment containing violacein and its derivative (deoxyviolacein) using Chromobacterium sp. NIIST-CKK-01 (MTCC 5522, NCIM 5341; Genbank Accession No. FJ982784). The method comprises the steps of maintaining and growing the bacterium in a specific medium under defined conditions of pH, temperature and agitation. At the end of incubation, pigment and biomass is separated from the culture broth, pigment is recovered from the biomass through solvent extraction and finally pigment is concentrated by drying.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: November 11, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventor: Krishnakumar Bhaskaran
  • Publication number: 20140309438
    Abstract: An object of the present invention is to provide a novel compound useful as an antifungal substance and a method for producing the compound.
    Type: Application
    Filed: October 22, 2012
    Publication date: October 16, 2014
    Applicants: THE RITSUMEIKAN TRUST, NATIONAL UNIVERSITY CORPORATION SHIZUOKA UNIVERSITY
    Inventors: Nobutaka Imamura, Kazuya Nakagawa, Shinji Tokuyama
  • Publication number: 20140220457
    Abstract: The present invention relates generally to substrates for making polymers and methods for making polymers. The present invention also relates generally to polymers and devices comprising the same.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 7, 2014
    Applicant: Avertica, Inc.
    Inventor: Nicholas Brendan Duck
  • Publication number: 20140142314
    Abstract: The present disclosure provides for an expression system for the production of blue pigment indigoidine. The system comprises a heterologous host cell, a DNA sequence encoding a Sc-IndB protein, and a DNA sequence encoding a Sc-IndC protein. The system may be configured for the co-expression of the Sc-IndB and Sc-IndC. DNA sequences encoding the Sc-IndB and Sc-IndC may be provided on at least one vector. Alternatively, the DNA sequences encoding the Sc-IndB and Sc-IndC may optionally be integrated into the genome of the heterologous host genome. The expression system may further comprise a sfp gene or a PPTase.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 22, 2014
    Applicant: UTAH STATE UNIVERSITY
    Inventor: Jixun Zhan
  • Patent number: 8703456
    Abstract: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: washing and cutting a fresh dioscorea into pieces with a specific dimension; drying the pieces of the fresh dioscorea for making the dried dioscorea contain a specific water content and a specific sulfur content; adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea; sterilizing the dioscorea; after the dioscorea being cooled down, inoculating the dioscorea with Monascus species; cultivating the dioscorea with an appropriate temperature, an appropriate humidity and an appropriate shacking frequency for an appropriate time period; and drying the cultivated red mold dioscorea with an appropriate water content.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: April 22, 2014
    Assignee: Sunway Biotech Co., Ltd.
    Inventors: Tzu-Ming Pan, Chun-Lin Lee
  • Publication number: 20140106413
    Abstract: The invention is directed to immobilized transaminases and methods of making and using them.
    Type: Application
    Filed: June 18, 2012
    Publication date: April 17, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Matthew D. Truppo, Jacob M. Janey, Gregory Hughes
  • Publication number: 20140080837
    Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.
    Type: Application
    Filed: December 20, 2011
    Publication date: March 20, 2014
    Applicant: Neurovive Pharmaceuticals AB
    Inventors: Steven James Moss, Matthew Alan Gregory, Barrie Wilkinson, Steven Gary Kendrew, Christine Janet Martin
  • Patent number: 8669081
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: March 11, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Hayley Binch, Jean-Damien Charrier, Simon Everitt, Julian M.C. Golec, David Kay, Ronald Knegtel, Andrew Miller, Francoise Pierard
  • Patent number: 8628942
    Abstract: A tetrapyrrole compound is prepared by cultivating bacterial cells of Escherichia coli, which cannot express the gene ypjD (b2611) due to the variation thereof, in a culture medium and obtaining the resulting tetrapyrrole compound having a porphyrin ring structure from the culture medium.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: January 14, 2014
    Inventor: Toru Ishibashi
  • Publication number: 20140011244
    Abstract: A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: Premier Research Labs, LP
    Inventor: Robert J. Marshall
  • Publication number: 20140011203
    Abstract: The genomic DNA of Streptoverticillium sp. 3-7, which produces UK-2, was analyzed to identify a region expected to be a UK-2 biosynthetic gene cluster. Moreover, by colony hybridization, DNAs in the region were successfully isolated. Further, the DNAs were used to prepare a strain in which the genes present in the region were disrupted. The strain was found not to produce UK-2. It was verified that the genomic region was the UK-2 biosynthetic gene cluster. Furthermore, Streptoverticillium sp. 3-7 was transformed by introduction of a vector in which the isolated UK-2 biosynthetic gene cluster was inserted. It was also found out that the UK-2 productivity by the transformant was improved about 10 to 60 times or more in comparison with that of the parental strain. Moreover, it was revealed that 2 copies of the UK-2 biosynthetic gene cluster were present per cell in these transformants, respectively.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 9, 2014
    Inventors: Koei KOBAYASHI, Naomi SUMIDA, Koji YANAI
  • Publication number: 20130295622
    Abstract: The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
    Type: Application
    Filed: November 30, 2011
    Publication date: November 7, 2013
    Applicant: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
    Inventors: Sandro Mauro, Daniela Fattori, Amalia Cipollone
  • Publication number: 20130203994
    Abstract: The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1 and Y2 are independently F or Cl, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.
    Type: Application
    Filed: May 18, 2011
    Publication date: August 8, 2013
    Applicant: SANDOZ AG
    Inventors: Dominic De Souza, Shreerang V. Joshi, Sachin Bhuta, Abhinay C. Pise, Dattatraya N. Chavan, Shashikant D. Metkar
  • Publication number: 20130198900
    Abstract: The present invention provides bioengineered organisms producing elevated levels of thiamine and/or thiamine derivatives. Particularly, the present invention discloses that modifying TPP-responsive riboswitch results in accumulation of thiamine and/or its derivatives.
    Type: Application
    Filed: September 7, 2011
    Publication date: August 1, 2013
    Applicants: BEN-GURION UNIVERSITY OF THE NEGEV, YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Asaph Aharoni, Samuel Bocobza, Michal Shapira
  • Publication number: 20130177950
    Abstract: A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
    Type: Application
    Filed: August 30, 2011
    Publication date: July 11, 2013
    Applicant: RIKEN
    Inventors: Hiroyuki Osada, Shunji Takahashi, Makoto Kawatani, Yoshiyuki Sakaki, Atsushi Toyoda
  • Publication number: 20130102778
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 25, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Hoffmann-La Roche Inc.
  • Publication number: 20130096318
    Abstract: Methods and materials for producing meso-biliverdin are provided where the methods include reacting phycocyanobilin with an amphoteric compound in a solvent to yield meso-biliverdin.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 18, 2013
    Applicant: Utah State University
    Inventor: Utah State University
  • Patent number: 8415121
    Abstract: Improved process for the isolation of laidlomycin from a fermentation broth includes increasing the pH of the fermentation broth and centrifuging the pH adjusted fermentation broth, resulting in an aqueous layer and a wet solid layer containing laidlomycin. After the aqueous layer is removed, the wet solid layer containing laidlomycin is dried. The process provides an efficient and high yielding method.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: April 9, 2013
    Assignee: Alpharma, LLC
    Inventor: Robert Sheridan
  • Publication number: 20130078272
    Abstract: Antifungal compounds, an antifungal compound extracted from Epicoccum purpurascens, also known as Epicoccum nigrum, methods of producing the antifungal compounds, isolates and compositions comprising the antifungal compounds, and methods of using the antifungal compounds.
    Type: Application
    Filed: December 9, 2010
    Publication date: March 28, 2013
    Applicant: Auckland UniServices Limited
    Inventor: Silas Granato Villas-Boas
  • Publication number: 20130074735
    Abstract: The present invention discloses a process for producing purple-blue natural pigment containing violacein and its derivative (deoxyviolacein) using Chromobacterium sp. NIIST-CKK-01 (MTCC 5522, NCIM 5341; Genbank Accession No. FJ982784). The method comprises the steps of maintaining and growing the bacterium in a specific medium under defined conditions of pH, temperature and agitation. At the end of incubation, pigment and biomass is separated from the culture broth, pigment is recovered from the biomass through solvent extraction and finally pigment is concentrated by drying.
    Type: Application
    Filed: March 10, 2011
    Publication date: March 28, 2013
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventor: Krishnakumar Bhaskaran
  • Publication number: 20130023017
    Abstract: There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene. A. The method of the present invention allows for the production of pyripyropene.
    Type: Application
    Filed: January 19, 2011
    Publication date: January 24, 2013
    Inventors: Hiroyuki Anzai, Kentaro Yamamoto, Kazuhiko Oyama, Mariko Tsuchida, Kimihiko Goto, Masaaki Mitomi
  • Publication number: 20130023583
    Abstract: A process for producing purified theaflavin extract is provided which comprises combining an organic solvent with tea leaves, extracting polyphenols from the tea leaves to produce an organic stock substrate solution; producing a second batch of tea leaves; grinding the second batch of tea leaves to produce stock fermentation enzyme; combining the stock substrate solution with the stock fermentation enzyme to produce a fermentation mixture; fermentation of the mixture to produce theaflavins; and, separating the theaflavins from the fermentation mixture to produce purified theaflavin extract. Oral dosage forms are provided which comprise an effective amount of the purified theaflavin extract. Methods of treatment of human physiological disorders are provided which comprise administering an oral dosage form.
    Type: Application
    Filed: September 27, 2012
    Publication date: January 24, 2013
    Applicant: JIANGSU DEHE BIO-TECH CO., LTD.
    Inventor: JIANGSU DEHE BIO-TECH CO., LTD.
  • Publication number: 20130018124
    Abstract: A process for making biodegradable a synthetic polymeric material thanks to the addition of one or more yeasts to the synthetic material is disclosed.
    Type: Application
    Filed: January 25, 2011
    Publication date: January 17, 2013
    Applicant: QUEENSBROOK LIMITED
    Inventor: Madrisano Catinari
  • Publication number: 20130017580
    Abstract: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: December 8, 2010
    Publication date: January 17, 2013
    Applicant: CODEXIS, INC.
    Inventors: Yong Koy Bong, Michael D. Clay, Steven J. Collier, Benjamin Mijts, Michael Vogel, Xiyun Zhang, Jun Zhu, Jovana Nazor, Derek Smith, Shiwei Song
  • Patent number: 8349418
    Abstract: It is intended to provide a natural biodegradable material having both properties of biodegradability and mechanical strength; a biodegradable film or container produced from the natural biodegradable material; a binder for producing the biodegradable material; and a method for producing these. A natural polymeric substance which has a cellulose-like property of having hydroxy group which is not present in a petroleum-derived polymeric compound, and which moreover has a polypropylene-like structure is obtained by the steps of using a cereal starch such as Kaoliang starch as a culture raw material, adding a microorganism belonging to the genus Bacillus to the raw material to conduct a culture, and recovering a viscous polymeric substance. A biodegradable material having biodegradability comparable to that of cellulose and also having a mechanical strength property of polypropylene can be obtained by using the natural polymeric substance as a binder and mixing starch and/or shell powder thereto.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: January 8, 2013
    Assignee: Seiko Sato
    Inventor: Seiko Sato
  • Publication number: 20130005001
    Abstract: The present invention relates to a method for producing racemic nebivolol represented by general formula (I) from the enantiomerically-pure compounds represented by formula (IVa) and (IVb); whereby racemic nebivolol is obtained through mixing enantiomerically-pure d-nebivolol and l-nebivolol which are synthesised independent of each other as enantiomerically-pure compounds through individual coupling of the 4 enantiomerically-pure key intermediates represented by formula (IIa-d) to the corresponding precursors represented by formula (IIIa-d); whereby d-nebivolol (Ia) is obtained through coupling (IIa) to (IIIb) or (IIb) to (IIIa) and l-nebivolol (Ib) is obtained through coupling (IIc) to (IIId) or (IId) to (IIIc), and PG in the intermediates represented by formula (IIa-d) is a hydrogen atom or an amine protection group, and X in the precursors represented by formula (IIIa-d) is a halogen atom, a hydroxyl group, an acyl group, an alkylsulfonyloxy group or an arylsulfonyloxy group, whereby intermedi
    Type: Application
    Filed: January 21, 2011
    Publication date: January 3, 2013
    Inventors: Gerhard Jas, Ilia Freifeld, Kurt Kesseler
  • Patent number: 8329395
    Abstract: The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganisms and isolated polynucleotides containing the mutations are also provided. In addition, methods for detecting a pathogenic microorganism in a clinical sample, assays for identifying an antibiotic, as well as, antibiotics identified by such assays are provided.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: December 11, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Markus G. Goese, John B. Perkins, Ghislain Schyns
  • Publication number: 20120295316
    Abstract: Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified strains. Novel genes allowing biosynthesis of allylmalonyl-CoA can be used for polyketide production with allylmalonyl extender unit.
    Type: Application
    Filed: July 9, 2010
    Publication date: November 22, 2012
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Hrvoje Petkovic, Enej Kuscer, Stefan Fujs, Gregor Kopitar, Peter Mrak, Gregor Kosec
  • Publication number: 20120284816
    Abstract: Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Inventors: Jonathan Page, Andrea T. Todd
  • Publication number: 20120225936
    Abstract: The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dedifferentiated cells of the species Tripterygium, and to the therapeutic applications of said extract.
    Type: Application
    Filed: November 5, 2010
    Publication date: September 6, 2012
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Nicolas Steward, Nadine Chomarat, Ngoc Thien N'Guyen
  • Publication number: 20120108775
    Abstract: A method for producing a photochromic polyester, the method including: a) providing a reaction solution having at least one ester monomer, a photochromic compound having or functionalized to have at least one hydroxyl group, and a metal-free catalyst; b) reacting the at least one ester monomer and the photochromic compound using the metal-free catalyst to produce a polymeric product, where the polymeric product has a photochromic polyester; and c) separating the polymeric product from the reaction solution. A photochromic polyester includes a photochromic compound covalently linked to a polyester and the polyester is obtained by polymerizing a lactone.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 3, 2012
    Applicant: XEROX CORPORATION
    Inventors: Santiago FAUCHER, Gabriel IFTIME, Kentaro MORIMITSU, Adela GOREDEMA, Jordan H. WOSNICK
  • Publication number: 20120094335
    Abstract: The subject invention pertains to a novel purified polypeptide having laccase activity and the nucleic acid sequences encoding the polypeptide. The disclosed polypeptide works at moderately high temperatures from below 20° C. to about 70° C., both acidic and alkaline pH conditions, high salt concentrations and in the presence of organo solvents. The high stability of the enzyme enables its wide applications under even extreme conditions. The invention also provides methods of producing the laccase enzyme.
    Type: Application
    Filed: May 10, 2010
    Publication date: April 19, 2012
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION,INC.
    Inventors: Julie A. Maupin-Furlow, Sivakumar Uthandi, Boutaiba Saad, Matthew A. Humbard
  • Patent number: 8143308
    Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 27, 2012
    Assignees: University of Massachusetts Lowell, The United States of America, as represented by the Secretary of the Army
    Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
  • Publication number: 20120059038
    Abstract: [Problem] Provided is a compound which is useful as an agent for treating trichophytosis, protozoan infection and/or Pneumocystis pneumonia. [Means for Solution] Capnodiaceae strain No. 339855 was collected and a polyketide compound was isolated from the cultural solution thereof It was confirmed that the polyketide compound or a salt thereof has a potent anti-Trichophyton activity and is useful as a pharmaceutical, particularly as an agent for treating trichophytosis, thereby completing the present invention. A cyclic compound of the present invention or a salt thereof may be used as agent for preventing or treating trichophytosis, protozoan infection and/or Pneumocystis pneumonia (formerly: carinii pneumonia).
    Type: Application
    Filed: May 13, 2010
    Publication date: March 8, 2012
    Applicant: Astellas Pharma Inc.
    Inventors: Keisuke Ohsumi, Teruhisa Masaki
  • Publication number: 20120034660
    Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.
    Type: Application
    Filed: February 5, 2010
    Publication date: February 9, 2012
    Applicants: KYOWA HAKKO BIO CO., LTD., DAINIPPON SUMITOMO PHARMA CO., LTD.
    Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai
  • Publication number: 20110312034
    Abstract: The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include the cleaving of starting molecules into molecular subunits and the assembly of the subunits into novel recombined molecules.
    Type: Application
    Filed: March 2, 2011
    Publication date: December 22, 2011
    Inventor: Dennis M. Brown
  • Patent number: 8076107
    Abstract: Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone ester are disclosed.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: December 13, 2011
    Assignee: Cargill, Incorporated
    Inventors: Subash Buddoo, Amanda Louise Rousseau, Dean Brady, James Lalonde, Yiming Yao, Yifong Wang
  • Publication number: 20110300282
    Abstract: Methods for preferentially hydrolyzing one stereoisomer of an isoxazoline diester over another, as well as an enzyme for facilitating the preferential hydrolysis are provided. Also provided are methods for providing mixtures of (RR) and (RS) monatin as well as (SS) and (SR) monatin, which methods can include the step of stereoselectively hydrolyzing an isoxazoline diester.
    Type: Application
    Filed: August 18, 2011
    Publication date: December 8, 2011
    Applicant: CARGILL, INCORPORATED
    Inventors: Dean Brady, Lucia H. Steenkamp, Amanda Louise Rousseau, Subash Buddoo, Paul A. Steenkamp
  • Publication number: 20110295009
    Abstract: The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.
    Type: Application
    Filed: July 16, 2009
    Publication date: December 1, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Cosima Dufour-Schroif, Joachim Wink, Martin Gerlitz, Helene Olivan, Michael Kurz
  • Publication number: 20110295023
    Abstract: The nucleotide sequence of a DNA involved in the biosynthesis of herboxidiene was determined. Utilizing this DNA, herboxidiene and analogues thereof can be efficiently produced.
    Type: Application
    Filed: May 27, 2009
    Publication date: December 1, 2011
    Applicants: MERCIAN CORPORATION
    Inventors: Kazuhiro Machida, Kaoru Okayama, Masashi Itoh, Asako Toyoda
  • Patent number: 8067213
    Abstract: There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination consisting of morphine, codeine, thebaine and oripavine.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: November 29, 2011
    Assignee: Tasmanian Alkaloids Pty., Ltd.
    Inventors: Anthony John Fist, Christopher James Byrne, Wayne Lyle Gerlach
  • Patent number: 8067195
    Abstract: The invention relates to a method for preparing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme obtained from Bacillus pumulis possessing acetyl hydrolasic activity.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: November 29, 2011
    Assignee: ACS Dobfar S.p.A.
    Inventors: Auro Roberto Tagliani, Gabriele Guastalegname, Giovanni Fogliato, Riccardo Monguzzi