Oxygen As Only Ring Hetero Atom Patents (Class 435/123)
  • Patent number: 10799548
    Abstract: Tobacco products comprising smokeless tobacco products and active ingredients, including those that antagonize nicotinic acetylcholine receptors, the TRPV1 channel, and/or the TRPA1 channel are disclosed. Nicotine replacement therapies comprising active ingredients, including those that antagonize nicotinic acetylcholine receptors, the TRPV1 channel, and/or the TRPA1 channel. The active ingredient may reduce or eliminate sensory irritation arising due to use of the product. Analgesic compositions comprising active ingredients. Methods of reducing taste and sensory irritation by employing an active ingredient.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 13, 2020
    Assignee: Altria Client Services LLC
    Inventors: Gerd Kobal, Georgios D. Karles, Munmaya K. Mishra
  • Patent number: 10626242
    Abstract: The invention relates to a plastic compound comprising at least one polyolefin and a biological entity that degrades said polyolefin. The invention further relates to a process for preparing a plastic article wherein at least one polyolefin and one biological entity that degrades said polyolefin are mixed at a temperature at which the polyolefin is in a partially or totally molten state.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 21, 2020
    Assignees: CARBIOS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS
    Inventors: Thierry Ferreira, Frederique Guillamot, Steven Colas
  • Patent number: 10480016
    Abstract: The present disclosure relates to genetically engineered microorganisms for biological oxidation of hydrocarbons, including production of alcohols from alkanes or epoxides from alkenes, and related methods and systems.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: November 19, 2019
    Assignee: Calysta, Inc.
    Inventors: Joshua A. Silverman, Drew D. Regitsky
  • Patent number: 10358431
    Abstract: Novel antimicrobial compounds against drug targets such as Eskape pathogens, Leishmania donovani, Mycobacterium tuberculosis, Clostridium difficile, Naegleria fowleri, and cancer are presented herein.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: July 23, 2019
    Assignees: University of South Florida, King Abdulaziz University
    Inventors: Danielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw
  • Patent number: 9562244
    Abstract: The present invention provides a method of producing a photosynthetic product, the method comprising maintaining a photosynthetic plant or algal cell suspension culture, in the presence of water, light and a carbonic acid-enriched growth medium. The carbonic acid may, for example be provided by feeding the photosynthetic plant cell suspension culture with a carbonic acid solution, a solid or liquid precursor thereof, or a gaseous mixture of carbon dioxide and one or more other gases. The invention also provides a method for producing a photosynthetic product, the method comprising maintaining a photosynthetic plant or algal cell suspension culture, in the presence of water, light and a carbon source selected from carbon dioxide and carbonic acid, wherein the culture is maintained at a pH of less than 7.0, preferably 4.5 to 5.5.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: February 7, 2017
    Assignee: NATURALLY SCIENTIFIC TECHNOLOGIES LIMITED
    Inventor: Peter Andrew Whitton
  • Patent number: 9179687
    Abstract: Heat-stabilized defatted rice bran (HDRB) is fermented with yeast to afford a food product having superior prebiotic for probiotic properties. Fermentation of HDRB with yeast yields a prebiotic composition that can promote the growth and/or activity of beneficial intestinal bacteria (probiotic) when consumed by an animal or human. The prebiotic and/or probiotic compositions can afford substances having desirable health effects when consumed. The yeast fermented, and the probiotic fermented extracts and residues will have several nutraceutical compounds including protein, phenolics, phytic acid, arabinose, bioactive isoflavones, dietary fibers and several others that will have health benefits. Inclusion of legumes during fermentation can synergistically enhance the bioactivities of HDRB. HDRB can be a source of growth medium for yeast/mold/microorganisms.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: November 10, 2015
    Assignee: Board of Trustees of The University of Arkansas
    Inventor: Navam Hettiarachchy
  • Publication number: 20150056669
    Abstract: The present invention provides various combinations of genetic modifications to a transformed host cell that provide increase conversion of carbon to a chemical product. The present invention also provides methods of fermentation and methods of making various chemical products.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 26, 2015
    Inventors: Hans LIAO, Christopher Patrick MERCOGLIANO, Travis Robert WOLTER, Michael Tai Man LOUIE, Wendy Kathleen RIBBLE, Tanya LIPSCOMB, Eileen Colie SPINDLER, Michael D LYNCH
  • Publication number: 20150057465
    Abstract: The present invention provides various combinations of genetic modifications to a transformed host cell that provide increase conversion of carbon to a chemical product. The present invention also provides methods of fermentation and methods of making various chemical products.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 26, 2015
    Inventors: Hans LIAO, Christopher Patrick MERCOGLIANO, Travis Robert WOLTER, Michael Tai Man LOUIE, Wendy Kathleen RIBBLE, Tanya LIPSCOMB, Eileen Colie SPINDLER, Michael D. LYNCH
  • Publication number: 20150050705
    Abstract: The invention relates to enzymatic methods for epoxidation of a non-cyclicaliphatic alken, or a terpen.
    Type: Application
    Filed: March 25, 2013
    Publication date: February 19, 2015
    Inventors: Henrik Lund, Lisbeth Kalum, Martin Hofrichter, Sebastian Peter
  • Patent number: 8796002
    Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ? chloroalcohols from ? chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: August 5, 2014
    Assignee: Codexis, Inc.
    Inventors: Yong Koy Bong, Michael Vogel, Steven J. Collier, Vesna Mitchell, Jagadeesh Mavinahalli
  • Publication number: 20140199734
    Abstract: The present invention relates to a method for the enzymatic synthesis of enantiomerically enriched (R)-amines of general formula [1][c], from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.
    Type: Application
    Filed: July 14, 2011
    Publication date: July 17, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Martin Schürmann, Wijnand Peter Helena Peeters, Natascha Hubertina Smeets, Helmut Schwab, Kerstin Steiner, Kateryna Mykoiayivna Lypetska, Gernot Strohmeier
  • Patent number: 8765420
    Abstract: The present invention relates to a novel method for preparing pterocarpan from isoflavan-4-ol. With the use of the method of the present invention, the absolute configuration of C3 and C4 positions on the B-ring of isoflavan-4-ols is maintained identically also in pterocarpans, and thus, enantiopure pterocarpans can be efficiently prepared.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: July 1, 2014
    Assignee: Gwangju Institute of Science and Technology
    Inventors: Hor-Gil Hur, Jae Hong Han, Ji-Young Seo
  • Publication number: 20140134672
    Abstract: Bioreactors, and particularly, photobioreactors having a reactor chamber and surge driver, and methods for using these devices, for example, for the production of carbon-based products are provided. The reactor chamber provides a housing for microorganisms and culture medium. The surge driver produces a surge of the microorganisms and/or culture medium in the reactor chamber.
    Type: Application
    Filed: July 5, 2012
    Publication date: May 15, 2014
    Inventors: Max B. Tuttman, David A. St. Angelo
  • Publication number: 20140057325
    Abstract: A method for the in vivo production of styrene from renewable substrates using a recombinant microorganism is disclosed. Additionally, a method for the in vivo production of styrene oxide from renewable substrates using a recombinant microorganism is also disclosed. In both cases, the host cell expresses at least one gene encoding a polypeptide that possesses phenylalanine ammonia lyase activity in addition to at least one gene encoding a polypeptide that possesses trans-cinnamic acid decarboxylase activity. In the case of styrene oxide, the host cell must additionally express at least one gene encoding a polypeptide that possesses styrene monooxygenase activity.
    Type: Application
    Filed: March 8, 2012
    Publication date: February 27, 2014
    Applicant: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of
    Inventors: David Ross Nielsen, Rebekah McKenna
  • Publication number: 20130274327
    Abstract: The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
    Type: Application
    Filed: August 4, 2011
    Publication date: October 17, 2013
    Inventors: Makoto Arita, Hiroyuki Arai, Yosuke Isobe, Tadafumi Kubota
  • Publication number: 20130273613
    Abstract: The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 17, 2013
    Inventors: Eric James Devroe, Sriram Kosuri, David Arthur Berry, Noubar Boghos Afeyan, Frank Anthony Skraly, Dan Eric Robertson, Brian Green, Christian Perry Ridley
  • Publication number: 20130269061
    Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 10, 2013
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
  • Publication number: 20130224808
    Abstract: A process for producing ethylene from a carbonaceous containing feedstock the process comprising the steps of a) reforming the carbonaceous containing feedstock into a first product stream comprising carbon dioxide, carbon monoxide and hydrogen; b) fermenting the first product stream with an acetogenic anaerobic bacteria to produce a second product stream comprising ethanol; c) concentrating ethanol from the second product stream into a third product stream and; d) dehydrating ethanol in the third product stream to produce ethylene.
    Type: Application
    Filed: November 2, 2011
    Publication date: August 29, 2013
    Applicant: Ineos Commercial Services UK Limited
    Inventors: Peter Simpson Bell, Graeme Alexander Parker, Neil Turnbull, Vaughn Clifford Williams
  • Patent number: 8501444
    Abstract: The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: August 6, 2013
    Assignee: Biocon Limited
    Inventors: Sanjay Tiwari, Chittnalli Ramegowda Naveen Kumar, Deepthy Sathyanathan, Anuj Goel, Harish Iyer
  • Publication number: 20130157322
    Abstract: A process for converting a substrate such as carbon monoxide to useful chemicals has been developed. The process involves providing a substrate comprising CO to a bioreactor which contains a culture of one or more micro-organisms and anaerobically fermenting the substrate to produce ethanol. The ethanol is next converted to one or more chemical products via the compound ethylene. The source of the CO can be an industrial process such as the ferrous metal products manufacturing. The microorganism can be Clostridium autoethanogenum, Clostridium ljundahlii or Clostridium ragsdalei.
    Type: Application
    Filed: August 26, 2011
    Publication date: June 20, 2013
    Applicant: LANZATECH NEW ZEALAND LIMITED
    Inventors: Sean Dennis Simpson, Christophe Daniel Mihalcea
  • Publication number: 20130130330
    Abstract: A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane compounds.
    Type: Application
    Filed: April 12, 2011
    Publication date: May 23, 2013
    Applicant: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF ME SCIENCES
    Inventors: Ping Zhu, Haili Cheng, Ruiyu Zhao, Kedi Cheng, Huixia He, Chao Meng, Huixin Zhu
  • Publication number: 20130059332
    Abstract: The present invention relates to a process for the production of an aqueous glucose solution from maize or maize kernels. The invention also relates to a glucose solution obtainable by this process, and to its use for the production of organic compounds. The process according to the invention comprises: a) fractionating dry milling of maize kernels, where the maize kernels are separated into a maize-starch-comprising endosperm fraction and a high-oil germ fraction and, if appropriate, a bran fraction; b) enzymatic liquefaction and saccharification of the maize starch in an aqueous suspension of the endosperm fraction, which gives an aqueous glucose solution comprising maize gluten; and c) depletion of the maize gluten and, if appropriate, any bran present from the aqueous glucose solution.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 7, 2013
    Applicant: BASF SE
    Inventors: Matthias Boy, Jong-Kyu Choi, Jin Won Chung, Markus Lohscheidt, Jong In Choi, Jae Yeol Seo, Jörg Braun, Mo Se Kim, Sung Hyun Kim, Arno Kochner
  • Publication number: 20130017582
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: Phyton Holdings, LLC
    Inventors: Venkataraman BRINGI, Prakash G. Kadkade, Christopher L. Prince, Braden L. Roach
  • Publication number: 20130004993
    Abstract: Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 3, 2013
    Applicants: University System of Georgia, Valdosta State University
    Inventor: Thomas J. Manning
  • Patent number: 8338143
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: December 25, 2012
    Assignee: Phyton Holdings, LLC
    Inventors: Venkataraman Bringi, Prakash Kadkade, Christopher Prince, Braden Roach
  • Publication number: 20120315672
    Abstract: The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.
    Type: Application
    Filed: November 10, 2010
    Publication date: December 13, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Effendi Leonard, Parayil K. Ajikumar, Kristala Lanett Jones Prather, Gregory Stephanopoulos, Kelly Thayer
  • Publication number: 20120297507
    Abstract: A method for producing leafy biomass from undifferentiated plant cells, the method comprising providing undifferentiated plant cells, contacting them with an agent that promotes differentiation of the cells into leafy tissue and growing the cells in a temporary liquid immersion culture system. This method of the invention may be used to produce polypeptides, and natural medicinal products, and can be used to capture carbon dioxide. A method of producing a polypeptide in plant cells in vitro comprising: providing undifferentiated plant cells containing chloroplasts that carry a transgenic nucleic acid molecule encoding the polypeptide, wherein the plant cells display homoplastomy; and propagating the cells according to the above method to produce leafy biomass containing the polypeptide.
    Type: Application
    Filed: August 12, 2010
    Publication date: November 22, 2012
    Applicant: Imperial Innovations Limited
    Inventors: Franck Michoux, Peter Nixon, James Gerard McCarthy
  • Publication number: 20120288891
    Abstract: The present disclosure relates to the use of pantothenate compounds as a non-genetic switch for the production of heterologous acetyl-CoA derived (HACD) compounds in microbial host cells. The invention provides genetically modified microorganisms that are more stable when stored and initially cultured under reduced pantothenate concentrations, cell culture media having reduced concentrations of pantothenate compounds, and methods of producing HACD compounds using the cell culture media and the genetically engineered microorganisms of the invention.
    Type: Application
    Filed: May 9, 2012
    Publication date: November 15, 2012
    Applicant: AMYRIS, INC.
    Inventor: Adam Meadows
  • Patent number: 8252559
    Abstract: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 28, 2012
    Assignee: The California Institute of Technology
    Inventors: Rudi Fasan, Frances H. Arnold
  • Publication number: 20120190086
    Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ? chloroalcohols from ? chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
    Type: Application
    Filed: June 22, 2010
    Publication date: July 26, 2012
    Applicant: CODEXIS, INC.
    Inventors: Yong Koy Bong, Michael Vogel, Steven J. Collier, Vesna Mitchell, Jagadeesh Mavinahalli
  • Publication number: 20120171719
    Abstract: Disclosed herein are transformed Yarrowia lipolytica comprising an exogenous polynucleotide encoding a polypeptide having sucrose invertase activity. Also disclosed are methods of using the transformed Y. lipolytica.
    Type: Application
    Filed: November 15, 2011
    Publication date: July 5, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Seung-Pyo Hong, John E. Seip, Quinn Qun Zhu
  • Publication number: 20120149886
    Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: April 10, 2009
    Publication date: June 14, 2012
    Applicant: MICROBIA, INC.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Patent number: 8183018
    Abstract: A process for preparing (meth)acrylic esters (F) of alcohols (A) having at least one epoxy group, in which at least one alcohol (A) having at least one epoxy group is esterified with (meth)acrylic acid (S) or is transesterified with at least one (meth)acrylic ester (D) in the presence of at least one enzyme, the alcoholic leaving group being stable under the reaction conditions in the case of the transesterification.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 22, 2012
    Assignee: BASF Aktiengesellschaft
    Inventors: Dietmar Haering, Uwe Meisenburg, Mathieu Chabanas, Gunter Lipowsky
  • Patent number: 8148118
    Abstract: The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea hydrogen peroxide adduct (UHP) as oxidant and lipase enzyme as catalyst. Under the influence of lipase, the chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate is converted to per-acid in situ by the oxidant urea hydrogen peroxide which in turn transfers oxygen to olefin inducing chirality to the product epoxide. Using this technique, important epoxide building blocks of different industrially important compounds can be prepared with good yield and moderate enantioselectivity. Chiral epoxidation of olefins with environment friendly catalytic system that can be recycled is highly desirable in the context of Green Chemistry for preparation of many industrially important compounds.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: April 3, 2012
    Assignee: Council of Scientific & Industrial Research
    Inventors: Amrit Goswami, Kuladip Sarma, Ajit Kumar Hazarika
  • Patent number: 8080391
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 20, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Patent number: 8053637
    Abstract: Reported herein are methods for obtaining stably transformed callus in Taxus media ‘Hicksii’, including particularly methods that involve using needles, stem, or bark peel as explant material for transformation. Also provided are descriptions of several promoter activities in directing reporter gene expression in Taxus media cells, in particular cells in suspension cultures, callus and needles. Transgenic plants (e.g., Taxus plants), plant cells, cell lines, and tissues (including seeds) are also provided, in particular those that express one or more enzymes in a paclitaxel biosynthesis pathway.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: November 8, 2011
    Assignee: Dianaplantsciences, Inc.
    Inventors: Helena V. Mathews, Vaka S. Reddy, Allan H. Lammers
  • Publication number: 20110250654
    Abstract: Glycerol or other reduced carbon sources may be used as a feedstock for the microbial production of chemical products under certain microaerobic conditions. For example, such production may occur under microaerobic or microrespiratory conditions in which electron acceptors are consumed in the reaction as quickly as they are added. In such reactions, the reaction product is at least as reduced as carbon source. Further, during such a reaction, at least some of the carbon source is used to generate cell mass. In addition, microorganisms with modified genomes are provided for carrying out the methods herein.
    Type: Application
    Filed: October 28, 2009
    Publication date: October 13, 2011
    Applicants: Glycos Biotechnologies, Inc., William Marsh Rice University
    Inventors: Ramon Gonzalez, Paul Campbell
  • Patent number: 8030048
    Abstract: The present invention relates to enantioselective epoxide hydrolase proteins isolated from marine microorganisms, which has high enantioselectivity to various epoxide substrates, and a method of preparing the epoxides with high enantio-purity by using the epoxide hydrolases. The enantioselective hydrolase protein of the present invention can be applied for the preparation of enantiopure epoxides with high bioactivity at a high yield.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: October 4, 2011
    Assignee: Korea Ocean Research and Development Institute
    Inventors: Sang-Jin Kim, Sung-Gyun Kang, Young-Ok Hwang, Jung-Hee Woo, Jang-Cheon Cho, Ji-Hyun Kang, Kae-Kyoung Kwon
  • Publication number: 20110230343
    Abstract: A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M.
    Type: Application
    Filed: October 14, 2009
    Publication date: September 22, 2011
    Applicant: BASF SE
    Inventors: Michael Schroers, Rainer Dyllick-Brenzinger, Michael Merk, Heiko Barg
  • Publication number: 20110190389
    Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds.
    Type: Application
    Filed: February 20, 2008
    Publication date: August 4, 2011
    Inventors: Linda Arterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Dutt Vinjamoori, Mary Van Elswyk
  • Publication number: 20110165634
    Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.
    Type: Application
    Filed: December 29, 2010
    Publication date: July 7, 2011
    Applicant: Solazyme, Inc.
    Inventors: Scott Franklin, Aravind Somanchi, Karen Espina, George Rudenko, Penelope Chua
  • Publication number: 20110086397
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 14, 2011
    Applicant: Phyton Holdings, LLC
    Inventors: Venkataraman BRINGI, Prakash G. Kadkade, Christopher L. Prince, Braden L. Roach
  • Publication number: 20110039312
    Abstract: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from procambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.
    Type: Application
    Filed: September 23, 2010
    Publication date: February 17, 2011
    Applicant: UNHWA
    Inventor: Young Woo Jin
  • Publication number: 20110033896
    Abstract: The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention.
    Type: Application
    Filed: April 9, 2009
    Publication date: February 10, 2011
    Applicant: BASF SE
    Inventors: Matthias Boy, Stephan Freyer, Julia Brodersen
  • Publication number: 20110033903
    Abstract: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from cambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.
    Type: Application
    Filed: September 23, 2010
    Publication date: February 10, 2011
    Applicant: UNHWA
    Inventor: Young Woo Jin
  • Publication number: 20110020867
    Abstract: Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon-based products of interest are provided.
    Type: Application
    Filed: July 20, 2010
    Publication date: January 27, 2011
    Applicant: JOULE UNLIMITED, INC.
    Inventors: Nikos B. Reppas, Brian D. Green
  • Publication number: 20110014664
    Abstract: The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.
    Type: Application
    Filed: May 22, 2008
    Publication date: January 20, 2011
    Inventors: Sanjay Tiwari, Chittnalli Ramegowda Naveen Kumar, Deepthy Sathyanathan, Anuj Goel, Harish Iyer
  • Publication number: 20100209978
    Abstract: Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid. Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or 3 which has a deletion, substitution, addition and/or insertion of one or more amino acids and exhibits protocatechuate 4,5-ring cleavage activity, present in the chromosomal DNA of microbial cells, has been disrupted; recombinant plasmids comprising the Tph gene and protocatechuate 3,4-dioxygenase gene; transformants obtained by introducing the recombinant plasmids into the disrupted strain; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of terephthalic acid.
    Type: Application
    Filed: May 9, 2008
    Publication date: August 19, 2010
    Applicants: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, NAGAOKA UNIVERSITY OF TECHNOLOGY, FORESTRY AND FOREST PRODUCTS RESEARCH INSTITUTE
    Inventors: Toshihisa Shimo, Kohei Mase, Yoshihiro Katayama, Eiji Masai, Masao Fukuda, Kiyotaka Shigehara, Seiji Ohara, Masaya Nakamura, Yuichiro Otsuka
  • Publication number: 20100136617
    Abstract: The present invention provides an industrially useful improved halohydrin epoxidase, a method for producing the same, and a method for producing an epihalohydrin or 4-halo-3-hydroxybutyronitrile using the same. The improved halohydrin epoxidase of the present invention consists of an amino acid sequence in which a specific amino acid substitution mutation is introduced into an amino acid sequence of a wild-type halohydrin epoxidase comprising predetermined amino acid sequences I and II.
    Type: Application
    Filed: March 7, 2008
    Publication date: June 3, 2010
    Applicant: MITSUBISHI RAYON CO., LTD.
    Inventors: Takanori Akiyama, Fujio Yu, Fumiaki Watanabe, Yuya Takikawa, Eiji Sato
  • Publication number: 20100136635
    Abstract: The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea hydrogen peroxide adduct (UHP) as oxidant and lipase enzyme as catalyst. Under the influence of lipase, the chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate is converted to per-acid in situ by the oxidant urea hydrogen peroxide which in turn transfers oxygen to olefin inducing chirality to the product epoxide. Using this technique, important epoxide building blocks of different industrially important compounds can be prepared with good yield and moderate enantioselectivity. Chiral epoxidation of olefins with environment friendly catalytic system that can be recycled is highly desirable in the context of Green Chemistry for preparation of many industrially important compounds.
    Type: Application
    Filed: November 27, 2009
    Publication date: June 3, 2010
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Amrit Goswami, Kuladip Sarma, Ajit Kumar Hazarika