Containing Six-membered Hetero Ring (e.g., Fluorescein, Etc.) Patents (Class 435/125)
  • Patent number: 10988786
    Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: April 27, 2021
    Assignees: SYMRISE AG, LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE
    Inventors: Ludger A. Wessjohann, Susann Herrmann, Martin Dippe, Torsten Geissler, Katrin Geissler, Jakob Peter Ley
  • Patent number: 10954543
    Abstract: Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producing flavanones, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: March 23, 2021
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Mattheos Koffas, John Andrew Jones
  • Patent number: 10858680
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: December 8, 2020
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • Patent number: 10711262
    Abstract: The storage stability of enzyme granules for detergents can be improved by incorporating a polyamine having a molecule with at least 10% w/w of nitrogen wherein at least 50% of the N atoms are present as amines.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: July 14, 2020
    Assignee: Novozymes A/S
    Inventors: Peter Dybdahl Hede, Ole Simonsen
  • Patent number: 10660935
    Abstract: A peptide consisting of an amino acid sequence of GPPGPAG (SEQ ID NO: 1) is disclosed. According to the present invention, a novel compound for improving memory disorder is provided.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: May 26, 2020
    Assignees: JAPAN BIO PRODUCTS Co., Ltd., National University Corporation University of Toyama
    Inventors: Chihiro Tohda, Taiichi Kaku, Hiroyuki Miyazaki
  • Patent number: 10519460
    Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 31, 2019
    Assignees: DANMARKS TENISKE UNIVESITET, KØBENHAVNS UNIVERSITET, CHR. HANSEN NATURAL COLORS A/S
    Inventors: Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Hilde Cornelijne Coumou, Rubini Maya Kannangara, Bjørn Madsen, Majse Nafisi, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Finn Thyge Okkels, Paiman Khorsand-Jamal, Dan Stærk, Birger Lindberg Møller
  • Patent number: 10502750
    Abstract: The present invention teaches methods useful for accurately and precisely analyzing cannabis plants, plant parts, and extract samples. In particular, the present invention teaches methods of extracting, and quantifying cannabinoid and terpene constituents.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: December 10, 2019
    Assignee: Biotech Institute, LLC
    Inventors: Matthew W. Giese, Mark Anthony Lewis, Laura Giese
  • Patent number: 10428360
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: October 1, 2019
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • Patent number: 10336978
    Abstract: The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: July 2, 2019
    Assignee: TEEWINOT TECHNOLOGIES LIMITED
    Inventors: Richard Peet, Malcolm J. Kavarana, Mingyang Sun, Peter C. Michels, John D. Rabenstein, C. Seth Pearson, Geoffrey M. Fox
  • Patent number: 10246689
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities lovastatin being converted to simvastatin and related compounds with minimal modifications.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: April 2, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xue Gao, Xinkai Xie
  • Patent number: 9970037
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: May 15, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xinkai Xie
  • Patent number: 9951360
    Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 24, 2018
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
  • Patent number: 9909156
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: March 6, 2018
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • Patent number: 9822374
    Abstract: A recombinant micro-organism such as Saccharomyces cerevisiae which produces and excretes into culture medium a stilbenoid metabolite product when grown under stilbenoid production conditions, which expresses in above native levels a ABC transporter which transports said stilbenoid out of said micro-organism cells to the culture medium. The genome of the Saccharomyces cerevisiae produces an auxotrophic phenotype which is compensated by a plasmid which also expresses one or more of said enzymes constituting said metabolic pathway producing said stilbenoid, an expression product of the plasmid is genetically modified to include a ubiquitination tag sequence. Expression of an enzyme participating in catabolism of phenylalanine by the Ehrlich pathway is optionally reduced compared to its native expression level.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: November 21, 2017
    Assignee: EVOLVA SA
    Inventors: Michael Patrik Katz, Thomas Durhuus, Hans Peter Smits, Jochen Förster
  • Patent number: 9765111
    Abstract: The invention provides a process for the separation of soy protein. The process begins with an aqueous extract or solution of soy protein, which is passed through at least one expanded bed absorption (EBA) process. The EBA process comprises contacting the aqueous extract or solution of soy protein with at least one adsorbent resin, said adsorbent resin comprising at least one ligand (L1 or L2), having particular chemical structures. Proteins of interest (e.g. trypsin inhibitor (TI) protein or beta-conglycinin) are isolated by eluting them from said adsorbent resin. The invention also provides various novel protein compositions obtainable via the method of the invention.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: September 19, 2017
    Assignee: Upfront Chromatography A/S
    Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Martin Pontoppidan
  • Patent number: 9399785
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: July 26, 2016
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • Patent number: 9394510
    Abstract: The present invention provides an apparatus for simultaneously producing different cannabinoids in different ratios. Specifically, the apparatus according to the invention produces tetrahydrocannabinolic acid (THCA) and cannabichormenic acid (CBCA) or cannabidiolic acid (CBDA) in different ratios, and it comprises a bioreactor that comprises a first automated supply system configured to deliver a substrate and a cannabinoid acid synthase, and a second automated system to cease the reaction; an extractor configured to recover the cannabionoids so produced; and a controller configured to modify at least on property of the reaction.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: July 19, 2016
    Assignee: FULL SPECTRUM LABORATORIES LIMITED
    Inventors: Richard Peet, Mingyang Sun, Robert Winnicki, Marc Donsky
  • Patent number: 9259396
    Abstract: The present invention relates to a method of preparing a solid form of soy isoflavone (e.g. genistein). In particular, the present invention relates to a method of preparing a solid form of soy isoflavone by precipitation with compressed antisolvent using a supercritical fluid to produce nano-sized particles of soy isoflavone with an improved dissolution rate and bioavailability. An oral composition or aerosolized formulation comprising the nanoparticles of the soy isoflavone prepared by the method of the present invention is also disclosed herein. The dissolution rate and bioavailability of the nanoparticles of the soy isoflavone prepared by the method of the present invention have a 2-fold increase and a 2.6-fold increase respectively as compared to those of the raw soy isoflavone.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: February 16, 2016
    Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
    Inventors: Kathy Qian Luo, Jinjie Xu
  • Patent number: 9181539
    Abstract: The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI).
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: November 10, 2015
    Assignees: Massachusetts Institute of Technology, The Research Foundation of State University of New York
    Inventors: Gregory Stephanopoulos, Christine Santos, Mattheos Koffas
  • Patent number: 9089605
    Abstract: This application describes quinone derivatives which target the redox site of Ape1/Ref1. Also included in the invention are pharmaceutical formulations containing the derivatives and therapeutic uses of the derivatives.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: July 28, 2015
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Mark R. Kelley, Richard F. Borch, Rodney L. Nyland, II
  • Patent number: 9090922
    Abstract: The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: July 28, 2015
    Assignee: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
    Inventors: Sandro Mauro, Daniela Fattori, Piero D'Andrea, Amalia Cipollone, Enzo D'Andrea, Carmela Ercolano
  • Patent number: 9057085
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: June 16, 2015
    Assignee: Codexis, Inc.
    Inventors: Steven J. Collier, Ee Ling Teo, Joly Sukumaran, Robert J. Wilson, Junye Xu
  • Publication number: 20150147786
    Abstract: A process for mechanical destructuring of starch-based biomass was developed that makes use of a short application of high compression, impact, and shearing forces. The biomass may be destructured using a specific energy input that is less than 40% of the total combustible energy of the biomass. The destructured starch-based biomass, with or without saccharification and/or in-feed glycosyl hydrolase enzymes, may be used in feed applications. The destructured starch-based may saccharified to produce syrups and fermentable sugars, and for production of products including ethanol using a biocatalyst.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 28, 2015
    Inventors: KATHLEEN A CLARKSON, F Glenn Gallagher, Aaron Perelman, Luis Fernando Romero Millan, Vivek Sharma, Jayarama K. Shetty, Daniel A. Slanac, Paula Johanna Maria Teunissen
  • Publication number: 20150126598
    Abstract: The present invention relates to a concentrated extract of cranberry (Vaccinium macrocarpon), the complex composition of which makes it possible to increase the antibacterial effects thereof, which is of use for the prevention or treatment of urinary infections, and in particular for the preventive treatment of urinary infections or treatment against the recurrence thereof. The invention also relates to a process for preparing such an extract, to food, nutraceutical or pharmaceutical compositions comprising the extract and to the use thereof in the treatment or prevention of urinary infections.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 7, 2015
    Inventors: Philippe Sanoner, Valerie Bochard, Lucie Charissou, Benedicte Lastique, Morgane Jacob, Patrice Thomas
  • Publication number: 20150107318
    Abstract: The method contains the following steps. In step A, supersonic waves are applied to Mountain Litsea fruits for excitation and sterilization. In step B, the inferior fruits and the cleaning water are removed from the water tank, placed in a fermentative tank, and left for fermentation. After the fermentation, a pressing and separation process is conducted. In step C, the superior fruits are placed in a separate fermentative tank for fermentation into mofetil alcohol. In step D, the superior fruits are alternatively mixed with pure water, crushed, and placed in a boiler for aging and sterilization. Then the crushed and aged fruits are placed in yet another fermentative tank with pure water for fermentation. After the fermentation, a pomace separation process is conducted. The separated pomace becomes a Mountain Litsea wine lees, whereas the separated water becomes a Mountain Litsea enzymatic liquid.
    Type: Application
    Filed: October 22, 2013
    Publication date: April 23, 2015
    Inventors: HENG-JUI HSU, TSU-YU HSU
  • Publication number: 20150087033
    Abstract: Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 26, 2015
    Inventors: Guangrong Zheng, Cesar Compadre, Martin Hauer-Jensen, Peter Crooks, Philip Breen
  • Patent number: 8980587
    Abstract: A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: March 17, 2015
    Assignee: RIKEN
    Inventors: Hiroyuki Osada, Shunji Takahashi, Makoto Kawatani, Yoshiyuki Sakaki, Atsushi Toyoda
  • Publication number: 20150037851
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: August 21, 2014
    Publication date: February 5, 2015
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • Patent number: 8940789
    Abstract: A method for producing 4?-demethylnobiletin or 4?-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in subgenus Metacitrus in genus Citrus or citrus fruits belonging to section Aurantium in subgenus Archicitrus in genus Citrus, or a water extract product thereof using one or more Aspergillus molds selected from Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus saitoi, and Aspergillus usamii to obtain a fermented product.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: January 27, 2015
    Assignee: Fuji Sangyo Co., Ltd.
    Inventors: Shuichi Kusano, Hiroshi Tamura
  • Publication number: 20150010964
    Abstract: A method for increasing the yield of total flavonoids in Ganoderma lucidum mycelium by an expansin comprises: (1) inoculating Ganoderma lucidum into the PD liquid fermentation medium, activating the culturing of the strains and obtaining a seed solution; (2) inoculating the seed solution into a liquid fermentation medium, culturing and adding the expansin solution, then further culturing, isolating and obtaining Ganoderma lucidum mycelium; (3) extracting flavonoids from the Ganoderma lucidum mycelium and obtaining total flavonoids. A plant expansin is used for the liquid fermentation production of flavonoids ingredients of Ganoderma lucidum, and the fermentation process and extraction method are optimized to increase greatly the yield of total flavonoids in Ganoderma lucidum.
    Type: Application
    Filed: April 7, 2013
    Publication date: January 8, 2015
    Applicants: SHANDONG QIHE BIO-TECHNOLOGY CO., LTD, INSTITUTE OF AGRICULTURAL RESOURCES & ENVIRONMENT, SHANDONG ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Qiang Yao, Zhiyuan Gong, Jianchang Su, Zhaohui Liu, Jilei Wang, Xingcheng Du, Xiao Liu, Xiaoyan Zhu, Qingxin Zhou, Shan Zhu, Yanwen Yang
  • Patent number: 8927237
    Abstract: An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: January 6, 2015
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Yoshikazu Ootsuka, Tomohiro Akeboshi, Akiko Yamazaki, Yusuke Iriyama
  • Publication number: 20140370557
    Abstract: Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds.
    Type: Application
    Filed: June 13, 2014
    Publication date: December 18, 2014
    Inventors: YAJUN YAN, YUHENG LIN
  • Publication number: 20140363858
    Abstract: Provided herein are methods for producing an ortho-hydroxylated phenylpropanoid. In one embodiment the method includes culturing a microbe that includes HpaBC activity in the presence of a phenylpropanoid substrate. Also provided are genetically engineered microbes engineered to have greater levels of HpaB and/or HpaC than a control microbe.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 11, 2014
    Inventors: YAJUN YAN, YUHENG LIN
  • Publication number: 20140356915
    Abstract: Processes are described for fractionating lignocellulosic biomass into cellulose, hemicellulose, and lignin, comprising fractionating lignocellulosic biomass in the presence of a solvent for lignin (such as ethanol), a hydrolysis catalyst (such as sulfur dioxide), and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose to produce hemicellulosic monomers; saccharifying the cellulose-rich solids to produce glucose; recovering the hemicellulosic monomers and the glucose, separately or in a combined stream, as fermentable sugars; and fermenting the fermentable sugars to a fermentation product having a higher normal boiling point than water. Process integration of mass and/or energy is disclosed in many specific embodiments. The fermentation product may include an organic acid, an alcohol, a diol, or combinations thereof.
    Type: Application
    Filed: May 23, 2014
    Publication date: December 4, 2014
    Applicant: API Intellectual Property Holdings, LLC
    Inventors: Theodora RETSINA, Vesa PYLKKANEN, Ryan P. O'CONNOR
  • Publication number: 20140349338
    Abstract: The present invention relates to novel bacteria and the uses thereof. The invention particularly relates to bacteria having a metabolic pathway ratio between Pentose phosphate and glycolysis greater than 0.5, and their uses in the chemical, pharmaceutical or agro-chemical industries, e.g., for producing compounds of industrial interest.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 27, 2014
    Applicant: DEINOVE
    Inventors: Jean-Paul Leonetti, Juha-Pekka Pitkanen, Paula Jouhten
  • Publication number: 20140341855
    Abstract: The invention relates to reuterin-producing strains of Lactobacillus brevis. These strains are useful in particular for the treatment or the prevention of conditions resulting from Helicobacter pylori infection.
    Type: Application
    Filed: November 30, 2011
    Publication date: November 20, 2014
    Applicant: COMPAGNIE GERVAIS DANONE
    Inventors: Peggy Garault, Gaelle Quere, Raphaelle Bourdet-Sicard
  • Publication number: 20140329286
    Abstract: The present invention relates to a processed food composition containing, as an active ingredient, psicose, which is a saccharide having the function of stimulating a daidzein conversion into equol by an intestinal microorganism in the human body.
    Type: Application
    Filed: October 15, 2012
    Publication date: November 6, 2014
    Inventors: Taek Beom Kim, Seong Bo Kim, Min Hae Kim, Sung Jae Yang, Jae Hong Han
  • Publication number: 20140315264
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Application
    Filed: January 15, 2014
    Publication date: October 23, 2014
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu SHIMADA, Setsuko YASUDA, Masayuki TAKAHASHI, Takashi HAYASHI, Norihiro MIYAZAWA, Yasuhiro ABIRU, Tadaaki OHTANI, Ikutaro SATO
  • Publication number: 20140242157
    Abstract: Provided herein are methods and compositions for treating a subject who has pulmonary damage or an injury caused by or who is at risk for an injury caused by an anti-vesicant agent. The compositions comprise cacao extracts that include a mixture of epicatechin and one or more epicatechin oligomers and a pharmaceutically acceptable carrier. Also provided are methods for fermenting cacao to enhance epicatechin and antioxidant content.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: CACAO BIO-TECHNOLOGIES, LLC
    Inventors: Daniel PRESTON, Randall B. MURPHY
  • Patent number: 8765445
    Abstract: The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: July 1, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Shigeto Uchiyama, Tomomi Ueno, Toshimi Suzuki
  • Publication number: 20140147886
    Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
    Type: Application
    Filed: March 5, 2013
    Publication date: May 29, 2014
    Applicant: ARKANSAS STATE UNIVERSITY
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
  • Patent number: 8735137
    Abstract: Disclosed herein are transformed Yarrowia lipolytica comprising an exogenous polynucleotide encoding a polypeptide having sucrose invertase activity. Also disclosed are methods of using the transformed Y. lipolytica.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: May 27, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Seung-Pyo Hong, John E. Seip, Quinn Qun Zhu
  • Publication number: 20140141476
    Abstract: Polypeptides having alkanoyl-CoA activity have been identified and characterized, as have nucleic acids encoding these polypeptides. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Application
    Filed: July 13, 2012
    Publication date: May 22, 2014
    Applicants: UNIVERSITY OF SASKATCHEWAN, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Jonathan E. Page, Jason M. Stout
  • Publication number: 20140141475
    Abstract: A process for treating a mixture of R,R- and S,S-lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme in the presence of a ketone solvent to produce a mixture comprising aliphatic ester of lactic acid corresponding to one lactide enantiomer, and the aliphatic ester of lactyllactic acid corresponding to the other lactide enantiomer. Also provided are processes for the production of S-lactic acid, S,S-lactide, poly-S-lactic acid, R-lactic acid, R,R-lactide, poly-R-lactic acid and stereocomplex polylactic acid.
    Type: Application
    Filed: August 21, 2012
    Publication date: May 22, 2014
    Applicant: Plaxica Limited
    Inventors: Edward Leslie Marshall, Jade Jocelyn Afriye Osei Tutu, Stephen Alexander Calder Smith
  • Patent number: 8709764
    Abstract: The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: April 29, 2014
    Assignee: Universiteit Gent
    Inventors: Sam Possemiers, Willy Verstraete, Arne Heyerick, Denis De Keukeleire
  • Publication number: 20140086879
    Abstract: Disclosed herein is an isolated Muscodor albus strain producing volatile organic compounds such as aristolene, 3-octanone and/or acetic acid ester, as well as cultures of said strain and compositions, metabolites and volatiles derived from said strain or culture as well as methods of obtaining said compositions, metabolites and volatiles and their methods of use for controlling pests. Also disclosed are artificial compositions having the same components and uses as the volatiles derived from the strain. A method for capturing and sampling the volatiles is also disclosed.
    Type: Application
    Filed: September 23, 2013
    Publication date: March 27, 2014
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Gary Strobel, Vu Phong Bui, Hai Su, Phyllis Himmel, Pamela Marrone, Lijuan Xing, Sarah Lewis
  • Patent number: 8673967
    Abstract: A process for producing a composition comprising at least 3% by weight of total tocopherols and tocotrienols comprises: providing a product obtained from palm oil comprising tocopherols and tocotrienols, together with free fatty acids and monoglycerides and diglycerides of fatty acids; hydrolysing at least part of the monoglycerides and diglycerides with a lipase to form the corresponding free fatty acids; removing at least part of the free fatty acids after hydrolysis; and recovering a composition comprising a higher level of tocopherols and tocotrienols than are present in the product obtained from palm oil.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: March 18, 2014
    Assignee: Loders Croklaan B.V.
    Inventors: Krishnadath Bhaggan, John B. Harris, Miriam Van Wanroij
  • Publication number: 20140051135
    Abstract: Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 20, 2014
    Applicant: DIANAPLANTSCIENCES, INC.
    Inventors: Helena V. Mathews, Sung-Yong Yoon, Mylavarapu Venkatramesh
  • Publication number: 20140024769
    Abstract: Process and methods for making glycolic acid chemical intermediates and derivatives from biomass are described herein.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 23, 2014
    Applicant: METABOLIX, INC.
    Inventors: Johan van Walsem, Erik Anderson, John Licata, Kevin A. Sparks, Christopher Mirley, M.S. Sivasubramanian
  • Publication number: 20140011244
    Abstract: A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: Premier Research Labs, LP
    Inventor: Robert J. Marshall