Abstract: Xanthone compositions are provided herein. Formulations containing such compositions and methods of using such formulations and compositions are also provided. The present description additionally sets forth processes for making one or more compositions including compositions capable of promoting collagen production, antioxidant compositions, and anti-inflammatory compositions.

Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.

Abstract: A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene involved in the biosynthesis pathway leading to a low molecular weight organic aglycon compound and a glycosyltransferase gene capable of glycosylating the produced aglycon.

Abstract: The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products.

Abstract: The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.

Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound

Abstract: This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity.

Abstract: A method is disclosed for forming a covalent bond between two groups having carbonyl radicals in accordance with the present reaction equation: where R1 is hydrogen, a carboxyl group or a C1-C6 alkyl and R2 is an aromatic or heteroaromatic radical which may possibly be monosubstituted or disubstituted with halogen and/or a C1-C6 alkyl or is a substituent having the formula -A-B-C-D where A and C are each a C1-C6 alkyl, carbonyl or a covalent bond, B is a heteroatom such as oxygen and sulphur and D is an aliphatic radical having 1 to 6 carbon atoms, or an aromatic or heteroaromatic radical which may possibly be substituted, or where R1 and R2 together form a cyclic alkyl radical which may possibly be monosubstituted or disubstituted with a C1-C6 alkyl radical and/or with a hydroxy radical and which may possibly contain a heteroatom such as oxygen or sulphur, and R3 is hydrogen or a C1-C6 alkyl, wherein the reaction is catalysed by the enzyme YerE.

Abstract: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.

Abstract: The present invention relates to a polypeptide with HMG-CoA reductase activity, to its polynucleotide congener and to a method for the production of a statin comprising over expression of said polypeptide.

Abstract: The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.

Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.

Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.

Abstract: Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly Streptomyces avermitilis, Nocardia farcinica or Streptomyces lincolnesis, in order to efficiently prepare ortho-dihydroxyisoflavones having an excellent antioxidant function and a whitening effect.

Abstract: The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.

Abstract: The present invention relates to a method of treating plant(s) against larval pests by the use of terreulactone. It also relates to a process for producing meroterpenoid from fungus Aspergillus terreus strain MTCC5390.

Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.

Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.

Abstract: The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.

Abstract: A process for producing a composition comprising at least 3% by weight of total tocopherols and tocotrienols comprises: providing a product obtained from palm oil comprising tocopherols and tocotrienols, together with free fatty acids and monoglycerides and diglycerides of fatty acids; hydrolysing at least part of the monoglycerides and diglycerides with a lipase to form the corresponding free fatty acids; removing at least part of the free fatty acids after hydrolysis; and recovering a composition comprising a higher level of tocopherols and tocotrienols than are present in the product obtained from palm oil.

Abstract: Fermentation media containing an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and at least one exogenous added ingredient that comprises a substrate for microbial growth are provided. Methods of making a fermentation medium comprising an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and methods for obtaining a fermentation product are also provided. The present invention is further directed to fermentation broths obtained by the media and methods. The present invention is also directed to feed additives produced from fermentation broths obtained by the methods.

Abstract: Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids.

Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.

Abstract: The present invention is directed to ester derivatives of levulinic acid that are useful as plasticizers and/or coalescent solvents in polymer compositions, compositions comprising the ester derivatives, methods of making the derivatives and the compositions, and the use of the derivatives as additives in polymer compositions.

Abstract: The present invention relates to a process for obtaining energetic compounds by means of electromagnetic energy produced by sunlight or artificial light by means of using phytoplankton cultures.

Abstract: The present invention provides a process for producing a composition containing a high concentration of aglucone isoflavones, which comprises adding glucone isoflavones to the fermentation of microorganisms which are generally recognized as safe, and can express or produce ?-glycosidase on a soy-based substrate. The present invention also provides a composition containing a high concentration of aglucone isoflavones produced in accordance with the process of the invention.

Abstract: A purified tea extract is improved in taste by reducing a percentage of gallates in the non-polymer catechins. A process according to the present invention for the production of a purified tea extract includes subjecting a tea extract to a hydrolysis treatment, causing the tea extract to adsorb on the activated carbon, and then bringing a basic aqueous solution or an aqueous solution of an organic solvent into contact with the activated carbon to elute the non-polymer catechins.

Abstract: This invention is directed to an integrated method for the processing of palm fruit bunches to oil and other products. The method comprises inter alia separating palm fruit carrying bunches into fruits and lignocellulosic empty fruit bunches, processing the fruits to form palm oil, and at least one lignocellulosic processing coproduct; generating an aqueous stream; producing a non-oil, non-alcohol, non-fatty acid ester third product from the oil, the lignocellulosic processing coproduct, the aqueous stream or from a combination thereof; processing at least a portion of the lignocellulosic empty fruit bunches, lignocellulosic processing coproduct or a combination thereof into a fourth product and optionally producing at least one fifth conversion product from the fourth product; and using at least a portion of the fourth product or a product of its conversion or a combination thereof.

Abstract: The present invention provides a method for selective production of theaflavin in large amounts at high yield, and in an easy and inexpensive manner. Specifically, it relates to a method for selective production of theaflavin whereby a processed plant extract containing epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate is combined with a plant cell culture having peroxidase activity for selective production of theaflavin.

Abstract: We describe the production of nucleotide sugars other than uridine diphosphate glucose (UDP-glucose), for example UDP-rhamnose, and the use of these nucleotide sugars in the modification of acceptor molecules.

Abstract: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.

Abstract: The invention relates to Fmoc (9-fluorenyl-methoxycarbonyl)-based polymeric conjugates. These conjugates are useful for extending the in-vivo circulation of protein and peptide drugs.

Abstract: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.

Abstract: The present invention relates to the process for the recovery of conjugated isoflavones of residues and sub-products of food industries based on the use of soy and its derivatives. It also concerns of isoflavones obtained from food composition containing isoflavones and from the fungus genetically modified used in this process, Aspergillus oryzae ATCC 22786 (RIB 430). More specifically, the present invention concerns of a process of conversion of conjugated isoflavones, in the form of isoflavone malonate and acetates, in glucosylated isoflavones, which through fermentative and enzymatic processes are transformed into aglycone isoflavones. The products obtained in this process, pass to show a promising therapeutic as nutritive application as previously described, and may be used as a functional food or as a functional ingredient.

Abstract: A semiconductor device includes a semiconductor package, a circuit board and an interval maintaining member. The semiconductor package has a body and a lead protruded from the body. The circuit board has a first land electrically connected to the lead. The interval maintaining member is interposed between the circuit board and the body. The interval maintaining member maintains an interval between the lead and the first land. Thus, an interval between the lead and the land is uniformly maintained, so that a thermal and/or mechanical reliability of the semiconductor device is improved.

Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.

Abstract: We describe a screening method for the identification of glycosyltransferase polypeptides that regioselectively modify aglycones and the use of said glycosyltransferase polypeptides to modify aglycones.

Abstract: Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids.

Abstract: The present invention provides a recombinant Penicillium chrysogenum strain characterized in that a gene selected from the list consisting of penDE, pcbAB and pcbC is inactivated and the use of such a strain for the preparation of a compound of interest.

Abstract: The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process.

Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.

Abstract: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.

Abstract: Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.

Abstract: An antioxidant material of the present invention contains flavonoid aglycon and vitamin C. The flavonoid aglycon is eriodictyol and/or diosmetin obtained by treatment of a raw material containing flavonoid glycoside derived from lemons, limes, or sudachis to form the aglycones thereof. It is preferred that this antioxidant material be produced through a step of mixing the flavonoid aglycon and the vitamin C after the treatment to form the aglycones. The treatment to form the aglycones is glycosidase treatment using a ?-glycosidase derived from a microorganism of the genus Aspergillus or Penicillium multicolor, or microbial fermentative treatment using a microorganism of the genus Aspergillus. An anti-deterioration agent and a food or beverage of the present invention contain the antioxidant material.

Abstract: The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.

Abstract: The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.

Abstract: The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products.

Abstract: The following provisional patent application refers to the methods and compositions relating to a novel use for enzymatic catalysis of C21-H30-O2 (delta-nine tetrahydrocannabinol (THC)) as an insect repellent, bactericide, and fungicide and dispensation methods as commercial reagent. The bio-synthesis of cannabinoids represents a landmark achievement in the field of composting, vector removal and ecological reconstitution. Although the benefits have been known for millennia, the advent of modern bio-engineering techniques brings these small seeds of native wisdom to bear on a broader and more industrialized scale—removing dangerous molds and pestilences such as mosquitoes from swamped and flooded regions, raw sewage areas, and disaster sites where ensuing vermin and harmful vectors may cause greater damage than the initial catastrophes.

Abstract: A gene encoding a methylated catechin synthase that can effectively synthesize methylated catechins having high antiallergic activity. The gene encoding a methylated catechin synthase contains at least one nucleotide sequence selected from the group consisting of SEQ ID NOs: 1, 3 and 5.

Abstract: The present invention provides an in vitro flavonoid-rich tissue of Belamcanda chinensis, which is produced in a tissue culture system using a B. chinensis tissue capable of proliferation, such as a seed, an embryo of said seed, a root, a leaf, a base of a leaf, or a young inflorescence of B. chinensis. The preferred in vitro flavonoid-rich tissue is a callus tissue or an fast-proliferated roots of B. chinensis which contain a very high content of flavonoid as compared to the wild type B. chinensis. The present invention further provides a method for inducing the formation of the callus tissue and the fast-proliferated roots of B. chinensis. It also provides a method for extracting the flavonoids and a quantitative method for determining the amount of total flavonoids from the in vitro flavonoid-rich tissue.