Containing Six-membered Hetero Ring (e.g., Fluorescein, Etc.) Patents (Class 435/125)
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Publication number: 20140024769Abstract: Process and methods for making glycolic acid chemical intermediates and derivatives from biomass are described herein.Type: ApplicationFiled: March 11, 2013Publication date: January 23, 2014Applicant: METABOLIX, INC.Inventors: Johan van Walsem, Erik Anderson, John Licata, Kevin A. Sparks, Christopher Mirley, M.S. Sivasubramanian
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Publication number: 20140011244Abstract: A method for producing naturally derived beneficial compounds including dispersing a microbiological culture media including at least one live probiotic organism, and at least one nutraceutical and/or at least one nutritive agent in distilled water to form a broth, incubating the broth at a predetermined temperature for a select period of time to induce probiotic activity; halting the probiotic activity, and separating the desired compound from the broth.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicant: Premier Research Labs, LPInventor: Robert J. Marshall
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Publication number: 20130344528Abstract: The invention relates to a thermo-photo-bioreactor and to a method for the culture and mass micropropagation of Deschampsia antarctica in vitro. The invention comprises a discontinuous immersion reactor for biomass micropropagation, including means for incorporating chemical inducing agents (salt, metals, organic compounds, etc.) and internal luminescence or illumination means (UV radiation and temperature) for supplying said chemical inducers and/or illumination during any growth phase of the vegetable or plant material (multiplication or propagation and/or maintenance). The invention is advantageous in that it can be used to produce large quantities of biomass of the aforementioned Antarctic species, while providing conditions suitable for said plant to produce metabolites that can be used for human health and personal care.Type: ApplicationFiled: November 9, 2011Publication date: December 26, 2013Applicant: UNIVERSIDAD SANTIAGO DE CHILEInventors: Gustavo Emilio Zuñiga Navarro, Alvaro Eduardo Sequeida Honorato, Alvaro Gonzalo Castro Oyarzun, Eduardo Andres Tapia Rodriguez, Humberto Godofredo Prieto Encalada, Pablo Andres Zamoro Cantillana
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Publication number: 20130337485Abstract: The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermediate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or intermediate thereof.Type: ApplicationFiled: December 20, 2011Publication date: December 19, 2013Applicant: LEK PHARMACEUTICALS D.DInventors: Peter Mrak, Tadeja Zohar, Matej Oslaj, Gregor Kopitar
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Patent number: 8597915Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.Type: GrantFiled: February 1, 2011Date of Patent: December 3, 2013Assignee: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Clemens Stückler, Kurt Faber
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Publication number: 20130316408Abstract: The invention discloses marine Streptomyces sp., a Pyranosesquiterpene compound, as well as a preparation method and uses thereof. Streptomyces sp. SCSIO 01689 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011257 on Jul. 18, 2011. The Streptomyces sp. SCSIO 01689 can produce the Pyranosesquiterpene compound with better anti-Escherichia coli activity and anti-Artemia activity, as well as Cyclo(D)-Pro-(D)-Ile, Cyclo(D)-Pro-(D)-Leu and Cyclo(D)-trans-4-OH-Pro-(D)-Phe with better anti-Vibrio anguillarum activity and anti-Artemia activity, thereby providing a new way for preparing the Cyclo(D)-Pro-(D)-Ile, the Cyclo(D)-Pro-(D)-Leu and the Cyclo(D)-trans-4-OH-Pro-(D)-Phe. The Pyranosesquiterpene compound can be used for preparing anti-Escherichia coli medicaments and anti-Artemia medicaments, as well as preparing condiments as a condiment precursor compound.Type: ApplicationFiled: June 18, 2012Publication date: November 28, 2013Applicant: South China Sea Institute Of Oceanology, Chinese Academy of SciencesInventors: Lijuan Long, Xinpeng Tian, Jie Li, Xiongming Luo, Zhenxiong Qi, Tuan Yin
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Publication number: 20130296417Abstract: A process for producing a purified extract comprising between about 40% and about 90% theaflavins is provided. Purified theaflavin extract produced by the disclosed process is provided which comprises less than about 5% TF1, between about 10% and about 60% TF2a, between about 5% and about 35% TF2b, and between about 10% and about 65% TF3. Individual dosage compositions are provided for the control of a physiological disorder comprising about 5% to about 95% theaflavins in a pharmaceutically acceptable vehicle or a dietary supplement vehicle. Further individual dosage compositions are provided which comprise an effective amount of substantially only one theaflavin species selected from the group consisting of TF1, TF2a, TF2b, and TF3. Individual dosage compositions are provided which comprise an effective amount of substantially only two theaflavin species selected from the group consisting of TF1 and TF2a, TF1 and TF2b, TF1 and TF3, TF2a and TF2b, TF2a and TF3, TF2b and TF3.Type: ApplicationFiled: June 28, 2013Publication date: November 7, 2013Applicant: JANGSU DEHE BIO-TECH CO., LTD.Inventors: Xiaowei Shi, Xueyn Ren, Jiannong Liu, Wenhao Ren, Yiznou Cao
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Publication number: 20130260426Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.Type: ApplicationFiled: December 7, 2011Publication date: October 3, 2013Inventors: Ee Lui Ang, Oscar Alvizo, Behnaz Behrouzian, Michael Clay, Steven Collier, Ellen Eberhard, Fan Jaslyn Fu, Shiwei Song, Derek Smith, Magnus Widegren, Robert Wilson, Junye Xu, Jun Zhu
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Publication number: 20130252289Abstract: A method for producing at least one compound selected from the group consisting of 1,8-cineole, and 1-methyl-1,4-cyclohexadiene is also described. The method includes culturing a microorganism on or within a culturing media in a container under conditions sufficient for producing the at least one compound.Type: ApplicationFiled: March 12, 2013Publication date: September 26, 2013Inventors: Gary A. Strobel, Angela R. Tomsheck
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Publication number: 20130209609Abstract: The invention relates to the use of a microorganism of the genus Brevibacterium for the biological degradation of ochratoxin A, in which the microorganism is preferably Brevibacterium casei, Brevibacterium linens, Brevibacterium iodinum or Brevibacterium epidermidis. In addition, the invention relates to a method for the production of ochratoxin ? using said microorganism.Type: ApplicationFiled: July 28, 2011Publication date: August 15, 2013Inventors: María Rosario Muñoz Moreno, Héctor Rodríguez López, Blanca De Las Rivas González Del Ray, Inés María Reverón Poján, Emilia Garcia Moruno, Francesca Doria, Antonella Costantini
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Publication number: 20130196013Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: March 15, 2013Publication date: August 1, 2013Applicant: MARRONE BIO INNOVATIONS, INC.Inventor: MARRONE BIO INNOVATIONS, INC.
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Publication number: 20130145496Abstract: The purpose of the present invention is to provide a novel flavonol 8-hydroxylase. The present invention relates to a flavin enzyme protein having a flavonol 8-hydroxylase activity, and a polynucleotide etc. encoding the same, and so on. The present invention provides: a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 3; a polynucleotide encoding a protein consisting of the amino acid sequence of SEQ ID No. 2; an expression vector and transformant comprising the polynucleotide; a method for screening a plant which blooms one or more yellow coloured flowers by using the polynucleotide; a method for producing a plant which blooms one or more yellow coloured flowers by introducing the polynucleotide into host cells; and a method for producing a flavin enzyme protein having a flavonol 8-hydroxylase activity, using the transformant.Type: ApplicationFiled: August 18, 2011Publication date: June 6, 2013Applicant: SUNTORY HOLDINGS LIMITEDInventor: Hideyuki Suzuki
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Publication number: 20130121978Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: December 17, 2012Publication date: May 16, 2013Applicant: MARRONE BIO INNOVATIONS, INC.Inventor: Marrone Bio Innovations, Inc.
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Publication number: 20130115252Abstract: A method of preparing genipin-rich materials from the fruit of Genipa americana fruit for their use as a cross-linking agent and as a raw material to produce colors is disclosed. The genipin-rich materials can be used in a broad range of applications including personal care, cosmetics, dietary supplements, packaging, textiles, beverages, foodstuffs, drugs, and animal feeds.Type: ApplicationFiled: November 7, 2012Publication date: May 9, 2013Applicant: Wild Flavors, Inc.Inventor: Wild Flavors, Inc.
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Patent number: 8426189Abstract: Fermentation media containing an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and at least one exogenous added ingredient that comprises a substrate for microbial growth are provided. Methods of making a fermentation medium comprising an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and methods for obtaining a fermentation product are also provided. The present invention is further directed to fermentation broths obtained by the media and methods. The present invention is also directed to feed additives produced from fermentation broths obtained by the methods.Type: GrantFiled: April 27, 2010Date of Patent: April 23, 2013Assignee: Fermalogic, Inc.Inventor: J. Mark Weber
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Patent number: 8420833Abstract: The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.Type: GrantFiled: April 29, 2009Date of Patent: April 16, 2013Assignee: The Regents of the University of CaliforniaInventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling
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Publication number: 20130084600Abstract: This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NADP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.Type: ApplicationFiled: November 19, 2012Publication date: April 4, 2013Applicant: WILLIAM MARSH RICE UNIVERSITYInventor: WILLIAM MARSH RICE UNIVERSITY
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Publication number: 20130084601Abstract: The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.Type: ApplicationFiled: June 14, 2011Publication date: April 4, 2013Applicant: AMOREPACIFIC CORPORATIONInventors: Jun Seong Park, Duck Hee Kim, Han Kon Kim, Eun Mi Kim, Byung Gee Kim
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Patent number: 8383382Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.Type: GrantFiled: September 24, 2010Date of Patent: February 26, 2013Assignee: Codexis, Inc.Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
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Publication number: 20130023018Abstract: An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).Type: ApplicationFiled: April 7, 2011Publication date: January 24, 2013Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Yoshikazu Ootsuka, Tomohiro Akeboshi, Akiko Yamazaki, Yusuke Iriyama
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Publication number: 20130017187Abstract: Disclosed is a pharmaceutical natural composition containing both statin compounds (mevinolin and mevinolinic acid) serving as cholesterol biosynthesis inhibitors and coenzyme Q (ubiquinone-10: CoQ10 and ubiquinone-9: CoQ9) compounds which are substances that inhibit factors causing complications such as myalgia involved in long-term use of the statin, prepared using Monascus sp.Type: ApplicationFiled: December 28, 2009Publication date: January 17, 2013Applicant: SUNGSHIN WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventor: Young-Hee Pyo
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Publication number: 20120315681Abstract: The patent application relates to a method of producing a monomer component from a genetically modified polyhydroxyalkanoate (PHA) biomass, wherein the biomass is heated in the presence of a catalyst to release a monomer component from the PHA.Type: ApplicationFiled: February 11, 2011Publication date: December 13, 2012Inventors: Johan van Walsem, Erik Anderson, John Licata, Kevin A. Sparks, Christopher Mirley, M.S. Sivasubramanian
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Publication number: 20120315680Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.Type: ApplicationFiled: July 2, 2012Publication date: December 13, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi Tang, Xinkai Xie
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Publication number: 20120301931Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.Type: ApplicationFiled: February 1, 2011Publication date: November 29, 2012Applicant: BASF SEInventors: Bernhard Hauer, Rainer Stürmer, Clemens Stückler, Kurt Faber
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Publication number: 20120288891Abstract: The present disclosure relates to the use of pantothenate compounds as a non-genetic switch for the production of heterologous acetyl-CoA derived (HACD) compounds in microbial host cells. The invention provides genetically modified microorganisms that are more stable when stored and initially cultured under reduced pantothenate concentrations, cell culture media having reduced concentrations of pantothenate compounds, and methods of producing HACD compounds using the cell culture media and the genetically engineered microorganisms of the invention.Type: ApplicationFiled: May 9, 2012Publication date: November 15, 2012Applicant: AMYRIS, INC.Inventor: Adam Meadows
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Publication number: 20120244582Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.Type: ApplicationFiled: September 24, 2010Publication date: September 27, 2012Applicant: CODEXIS, INC.Inventors: Steven James Collier, Ee Ling Teo, Joly Sukumaran, Robert John Wilson, Junye Xu
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Patent number: 8268595Abstract: This invention is directed to an integrated method for the processing of palm fruit bunches to oil and other products. The method comprises inter alia separating palm fruit carrying bunches into fruits and lignocellulosic empty fruit bunches, processing the fruits to form palm oil, and at least one lignocellulosic processing coproduct; generating an aqueous stream; producing a non-oil, non-alcohol, non-fatty acid ester third product from the oil, the lignocellulosic processing coproduct, the aqueous stream or from a combination thereof; processing at least a portion of the lignocellulosic empty fruit bunches, lignocellulosic processing coproduct or a combination thereof into a fourth product and optionally producing at least one fifth conversion product from the fourth product; and using at least a portion of the fourth product or a product of its conversion or a combination thereof.Type: GrantFiled: December 29, 2009Date of Patent: September 18, 2012Assignee: Eyal Researach Consultants Ltd.Inventors: Aharon Eyal, Carmi Raz
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Publication number: 20120202256Abstract: A method of producing human metabolites of simvastatin or lovastatin, and more particularly, a method of producing human metabolites of simvastatin and lovastatin by using bacterial cytochrome P450 BM3(CYP102A1) or mutants thereof, and a composition and kit therefor.Type: ApplicationFiled: August 24, 2010Publication date: August 9, 2012Applicant: GLO BIOTECHInventors: Chul Ho Yun, Keon Hee Kim, Dong Hyun Kim, Ji Yeon Kang, Sun Ha Park
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Publication number: 20120196333Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.Type: ApplicationFiled: March 12, 2012Publication date: August 2, 2012Applicant: LEK PHARMACEUTICALS D.D.Inventors: ZDENKO CASAR, TOMAZ MESAR, GREGOR KOPITAR, PETER MRAK, MATEJ OSLAJ
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Publication number: 20120190038Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.Type: ApplicationFiled: October 8, 2010Publication date: July 26, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi Tang, Xue Gao, Xinkai Xie
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Publication number: 20120129230Abstract: Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.Type: ApplicationFiled: December 9, 2011Publication date: May 24, 2012Inventors: Pirkko Suominen, Aristos Aristidou, Merja Penttila, Marja Ilmen, Laura Ruohonen, Kari Koivuranta, Kevin Roberg-Perez
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Publication number: 20120101152Abstract: A method for producing 4?-demethylnobiletin or 4?-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in subgenus Metacitrus in genus Citrus or citrus fruits belonging to section Aurantium in subgenus Archicitrus in genus Citrus, or a water extract product thereof using one or more Aspergillus molds selected from Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus saitoi, and Aspergillus usamii to obtain a fermented product.Type: ApplicationFiled: March 10, 2010Publication date: April 26, 2012Inventors: Shuichi Kusano, Hiroshi Tamura
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Publication number: 20120094336Abstract: Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.Type: ApplicationFiled: August 12, 2009Publication date: April 19, 2012Inventor: Bert Steffan
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Publication number: 20120064583Abstract: The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means.Type: ApplicationFiled: July 11, 2011Publication date: March 15, 2012Applicant: SYNEXA LIFE SCIENCES (PROPRIETARY) LIMITEDInventors: Wade EDWARDS, Winston Daniel LEUKES, P. G. LOURENS, Sheena Janet FRASER
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Publication number: 20120052535Abstract: Methods for producing heterologous terpenes, terpenoids and/or small molecules in transgenic glandular trichome-bearing plants are provided, as well as the transgenic glandular trichome-bearing plants capable of producing the heterologous terpenes, terpenoids and small molecules. The genetically engineered glandular trichome-bearing plants contain and express one or more genes which encode proteins active in the biosynthetic pathways which produce the terpenes, terpenoids and small molecules. As a result, the essential oil of the transgenic plant is enriched for the heterologous or homologous terpenes, terpenoids and/or small molecules Storage of the essential oil in the glandular trichomes of the plant reduces the volatility and cytotoxic capacity of the heterologous molecules, thereby increasing yield and decreasing damage to the transgenic plant.Type: ApplicationFiled: March 26, 2010Publication date: March 1, 2012Inventors: Bernd Markus Lange, Rigoberto Rios-Estepa, Glenn W. Turner
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Publication number: 20120034661Abstract: The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI).Type: ApplicationFiled: May 5, 2011Publication date: February 9, 2012Applicants: The Research Foundation of State University of New York, Massachusetts Institute of TechnologyInventors: Gregory Stephanopoulos, Christine Santos, Mattheos Koffas
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Publication number: 20120029198Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.Type: ApplicationFiled: December 22, 2010Publication date: February 2, 2012Applicant: EASTMAN CHEMICAL COMPANYInventors: Liu Deng, Neil Warren Boaz
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Publication number: 20120021080Abstract: Provided herein are methods of making cocoa polyphenol preparations, which methods comprises harvesting cocoa polyphenols, for example, procyanidins, from the cell suspension culture. In examples of these methods, the resultant cocoa polyphenol preparation is substantially (or in some cases, completely) free of detectable caffeine and theobromine, and more generally substantially free of xanthine alkaloids. Methods of producing a cell suspension culture of cacao cells are also described, including cell suspension cultures useful for making cocoa polyphenol and, more specifically, procyanidin preparations. Theobroma and Herrania sp cell suspension cultures and cocoa polyphenol preparations made therefrom are also provided, in particular xanthine alkaloid-free (or caffeine- and/or theobromine-free) cocoa polyphenol preparations.Type: ApplicationFiled: May 4, 2009Publication date: January 26, 2012Applicant: DIANAPLANTSCIENCES, INC.Inventors: Mylavarapu Venkatramesh, D. Ry Wagner, Sonia Lall, Frederic Y. Lejard, Sung-Yong H. Yoon
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Publication number: 20110318309Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.Type: ApplicationFiled: February 25, 2010Publication date: December 29, 2011Applicant: KABUSHIKI KAISHA YAKULT HONSHAInventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
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Publication number: 20110250656Abstract: The present invention relates to the field of biotechnological production of polyketide based colorants from filamentous fungi, in particular a method for preparing a biomass comprising a Monascus-like pigment composition from a nontoxigenic and non-pathogenic fungal source. The present invention further relates to use of the Monascus-like pigment composition as a colouring agent for food items and/or non-food items, and a cosmetic composition comprising the Monascus-like pigment composition.Type: ApplicationFiled: August 28, 2008Publication date: October 13, 2011Applicant: DTU, TECHNICAL UNIVERSITY OF DENMARKInventors: Sameer A.S. Mapari, Anne S. Meyer, Jens C. Frisvad, Ulf Thrane
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Publication number: 20110251408Abstract: Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.Type: ApplicationFiled: December 17, 2009Publication date: October 13, 2011Applicant: DIANAPLANTSCIENCES, INC.Inventors: Helena V. Mathews, Sung-Yong Yoon, Mylavarapu Venkatramesh
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Patent number: 8030432Abstract: The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.Type: GrantFiled: December 10, 2009Date of Patent: October 4, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Nicole Favreau
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Publication number: 20110223640Abstract: The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising the polynucleotide of the lovE transcription regulator gene from Aspergillus terreus. Furthermore, the invention provides a host for the production of above mentioned statines comprising the polynucleotide of the lovE transcription regulator gene from Aspergillus terreus.Type: ApplicationFiled: September 21, 2009Publication date: September 15, 2011Inventors: Marco Alexander Van Den Berg, Marcus Hans
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Publication number: 20110207604Abstract: A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.Type: ApplicationFiled: February 24, 2011Publication date: August 25, 2011Applicant: MARRONE BIO INNOVATIONSInventors: Ratnakar Asolkar, Marja Koivunen, Pamela Marrone, Ana-Lucia Cordova-Kreylos, Huazhang Huang
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Process for improved recovery of fermentation products from intracellular and extracellular presence
Publication number: 20110201054Abstract: The present invention increases yield of the target fermented molecules by spray drying the fermentation broth and reducing the process volume to nearly one tenth the original. Thus, none of the target molecules are lost and requirements of the solvent and the other conventional method process equipments and processing materials are reduced considerably. Product recovery is improved. A major saving in the waste water treatment offsets spray drying and offers better process economics.Type: ApplicationFiled: March 18, 2010Publication date: August 18, 2011Inventors: Dilip S. Mehta, Anselm de Souza -
Publication number: 20110189134Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: ApplicationFiled: September 18, 2009Publication date: August 4, 2011Applicants: OTSUKA PHARMACEUTICAL CO., LTD., OTSUKA FOODS CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Publication number: 20110189726Abstract: The invention relates to a process for obtaining monacolin J derivatives (I), wherein R1 is COR2, wherein R2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing microorganism; and acylating the hydroxyl group present in the C8 position of the monacolin J previously obtained by means of adding a suitable acylating agent to the fermentation medium to obtain the desired monacolin J derivative (I).Type: ApplicationFiled: October 14, 2009Publication date: August 4, 2011Applicant: NEURON BIOPHARMA, S.A.Inventors: Sonia Campoy Garcia, Alberto Zafea Gómez, José Luis Adrio Fondevila, Javier Velasco Alvarez
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Publication number: 20110178295Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.Type: ApplicationFiled: April 2, 2008Publication date: July 21, 2011Applicant: LEK PHARMACEUTICALS D.D.Inventors: Zdenko Casar, Tomaz Mesar, Gregor Kopitar, Peter Mrak, Matej Oslaj
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Publication number: 20110177237Abstract: A method to utilize a chemical genus of chromen-4-one derivatives as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water and subject to biofouling based on the chromen-4-one compounds, as well as a method of obtaining one of such chromen-4-one antifouling compounds, 4?,5,7-trihydroxy-isoflavone, from a natural source. Particularly exemplary of such substituted chromen-4-one antifouling compounds are provided and they are 4?,5,7-trihydroxy-isoflavone, 4?,5-dihydroxy-3,6,7,8 tetramethoxy-flavone, 3?,5-dihydroxy-3,4?,6,8 tetramethoxy-flavone, 4?,5-dihydroxy-3,6,7-trimethoxy-flavone, 4?,5,7-trihydroxy-flavone, 3?,4?,6,7-tetrahydroxy-flavone, and 5-monohydroxy-flavone.Type: ApplicationFiled: March 20, 2009Publication date: July 21, 2011Inventors: Peiyuan Qian, Xiaojian Zhou, Hongping He, Ying Xu
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Patent number: 7982057Abstract: The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.Type: GrantFiled: March 15, 2006Date of Patent: July 19, 2011Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda