Fat; Fatty Oil; Ester-type Wax; Higher Fatty Acid (i.e., Having At Least Seven Carbon Atoms In An Unbroken Chain Bound To A Carboxyl Group); Oxidized Oil Or Fat Patents (Class 435/134)
  • Patent number: 11111510
    Abstract: The invention provides methods and systems for the production of lipid products from a gaseous substrate using a two stage fermentation process. The method comprises providing a gaseous substrate comprising CO, CO2 or H2 or mixtures thereof, to a first bioreactor containing a culture or one or more microorganisms, and fermenting the substrate to produce acetate. The acetate from the first bioreactor is then provided to a second bioreactor, where it is used as a substrate for fermentation to lipids by one or more microalgae.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: September 7, 2021
    Assignees: LanzaTech New Zealand Limited, DBT-IOC Centre for Advanced Bio-Energy Research
    Inventors: Sean Dennis Simpson, Sebastian Michal Bernasek, Deepak K Tuli
  • Patent number: 11053523
    Abstract: A method of producing lipids, containing the steps of: culturing an alga belonging to the genus Nannochloropsis; and producing fatty acids or lipids containing the same as components; wherein expressions of genes encoding a ?12-desaturase and a ?6-desaturase are enhanced in the alga; and a transformant of an alga belonging to the genus Nannochloropsis, wherein expressions of genes encoding a ?12-desaturease and a ?6-desaturease are enhanced.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: July 6, 2021
    Assignee: Kao Corporation
    Inventor: Tatsuro Ozaki
  • Patent number: 11053287
    Abstract: Methods for increasing carbon-based chemical product yield in an organism by increasing carbon uptake and/or altering a pathway to or from an overflow metabolite in the organism, nonnaturally occurring organisms having increased carbon-based chemical product yield with increased carbon uptake and/or an altered pathway to or from an overflow metabolite, and methods for producing a carbon-based chemical product with these organisms are provided.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: July 6, 2021
    Assignee: INV Nylon Chemicals Americas, LLC
    Inventors: Alexander Brett Foster, Ana Teresa dos Santos Brito Mendes Roberts, Arghya Barman, Jonathan Kennedy
  • Patent number: 11053557
    Abstract: An improved dry grind system and method for producing a sugar stream from grains or similar carbohydrate sources and/or residues, such as for biofuel production, using membrane filtration. In particular, a sugar/carbohydrate stream, which includes a desired Dextrose Equivalent (DE) where DE describes the degree of conversion of starch to dextrose (aka glucose) and/or has had removed therefrom an undesirable amount of unfermentable components, can be produced after saccharification and prior to fermentation (or other sugar conversion process) using membrane filtration, with such sugar stream being available for biofuel production, e.g., alcohol production, or other processes. In addition, the systems and methods also can involve the removal of certain grain components, e.g., corn kernel components, including protein, oil and/or fiber, prior to fermentation or other conversion systems. In other words, sugar stream production and/or grain component separation occurs on the front end of the system and method.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 6, 2021
    Assignee: Fluid Quip Technologies, LLC
    Inventors: Neal Jakel, Albert Pollmeier
  • Patent number: 11046979
    Abstract: The present invention provides a mutant algal microorganism that has a mutation that causes attenuated expression of TrifuncB and/or TrifuncA and as a result produces more lipids than a control algal microorganism. The mutant algal microorganism can further include a mutation in a gene encoding a peroxisomal beta-oxidation pathway protein, such as an ACO1 or PXA1 gene, or a glyoxylate pathway protein, such as an ICL1 gene, that results in attenuated expression and further increased lipid production. Furthermore, provided herein are methods of producing lipids using the mutant algal microorganisms and methods of making the mutant microorganisms.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: June 29, 2021
    Assignee: Synthetic Genomics, Inc.
    Inventors: Eric R. Moellering, Tom Carlson
  • Patent number: 11046635
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: June 29, 2021
    Assignee: GENOMATICA, INC.
    Inventors: Zhihao Hu, Fernando Valle
  • Patent number: 11034987
    Abstract: An improved dry grind system and method for producing a sugar stream from grains or similar carbohydrate sources and/or residues, such as for biofuel production. In particular, a sugar/carbohydrate stream, which includes a desired Dextrose Equivalent (DE) where DE describes the degree of conversion of starch to dextrose (aka glucose) and/or has had removed therefrom an undesirable amount of unfermentable components, can be produced after saccharification and prior to fermentation (or other sugar conversion process), with such sugar stream being available for biofuel production, e.g., alcohol production, or other processes. In addition, the systems and methods also can involve the removal of certain grain components, e.g., corn kernel components, including protein, oil and/or fiber, prior to fermentation or other conversion systems. In other words, sugar stream production and/or grain component separation occurs on the front end of the system and method.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: June 15, 2021
    Assignee: Fluid Quip Technologies, LLC
    Inventors: Neal Jakel, John Kwik, Michael Franko, Andrew Whalen
  • Patent number: 11020365
    Abstract: This invention relates to a mixture of at least three fatty acids selected from palmitic acid, oleic acid, stearic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), azelaic acid and myristic acid. This invention also relates to the use of the aforesaid mixture in the treatment of inflammatory pathologies.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: June 1, 2021
    Assignee: AGAIN LIFE ITALIA SRL
    Inventor: Lodovico Burattin
  • Patent number: 11015166
    Abstract: A method of extracting frustules from benthic pennate diatoms is disclosed. The method includes culturing benthic pennate diatoms in an industrial biofilm process, wherein in the industrial biofilm process the benthic pennate diatoms are growing on at least one surface in a water-containing compartment and wherein the benthic pennate diatoms forms a biofilm on the at least one surface; harvesting the benthic pennate diatoms from the at least one surface; and extracting the frustules by separating the frustules from organic biomass contained in the benthic pennate diatoms.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: May 25, 2021
    Assignee: SWEDISH ALGAE FACTORY AB
    Inventors: Sofie Allert, Angela Wulff
  • Patent number: 10995348
    Abstract: A method of producing lipids, comprising the steps of: culturing a transformant in which the expression of a gene encoding at least any one of the following proteins (A) to (D) is enhanced in a cyanobacteria cell, and producing fatty acids or lipids containing these fatty acids as components. (A) a protein consisting of the amino acid sequence set forth in SEQ ID NO: 1; (B) a protein consisting of an amino acid sequence having 60% or more identity with the amino acid sequence of the protein (A), and having ?-ketoacyl-ACP synthase activity; (C) a protein consisting of the amino acid sequence set forth in SEQ ID NO: 44; and (D) a protein consisting of an amino acid sequence having 60% or more identity with the amino acid sequence of the protein (C), and having ?-ketoacyl-ACP synthase activity.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: May 4, 2021
    Assignee: Kao Corporation
    Inventors: Mika Terai, Akihito Kawahara, Tatsuro Ozaki
  • Patent number: 10995351
    Abstract: Systems and methods for producing carbohydrate (e.g., sugar) streams (and recycling enzymes) from a pretreated or untreated biomass such as cellulosic feedstock, including, for example, “brown stock” feedstock, or waste or recycled fiber sludge produced in the pulp and paper industry, such as for biochemical (e.g., biofuel) production, are provided. In one example, the system and method can produce high purity C6 (glucose and/or fructose) and/or C5 (xylose) sugar streams, and other carbohydrates and/or fibrous materials, from cellulosic feedstocks, such as brown stock or waste fiber sludge, that can be effectively converted into various biochemical products, such as ethanol.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: May 4, 2021
    Assignee: Fluid Quip Technologies, LLC
    Inventors: Jeffrey P Robert, Neal Jakel, Donald M. Cannon
  • Patent number: 10988784
    Abstract: Methods for producing a bioproduct selected from acetone, isopropanol and a combination thereof with a microorganism in a fermentor are disclosed. The methods include separating cells of the microorganism from a fermentation broth to form separated cells and recycling at least a fraction of the separated cells to the fermentor to achieve one or more of the following: (1) cell concentration in said fermentor greater than 2 g/L; mass yield on a first feedstock greater than 32%; productivity greater than 0.12 g/L/h; and bioproduct titer greater than 10 g/L.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: April 27, 2021
    Assignee: WHITE DOG LABS, INC.
    Inventors: Bryan Patrick Tracy, Shawn William Jones, Daniel Knox Mitchell, Aharon M. Eyal, Karthikeyan Ramachandriya
  • Patent number: 10913960
    Abstract: A microbial cell, which is genetically modified to increase the expression relative to the corresponding genetically unmodified cell of an AlkB alkane hydroxylase (Eb) having an amino acid sequence at least 95% identical with the amino acid sequence of SEQ ID NO: 1 and a wax-ester synthase (Ef) having an amino acid sequence at least 95% identical with the amino acid sequence of SEQ ID NO: 2. The cell does not have a genetic modification that increases formation of a carboxylic acid or a carboxylate ester from a simple carbon source.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 9, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Steffen Schaffer, Thomas Haas, Wilhelm Bruegging, Ralf Meier
  • Patent number: 10907223
    Abstract: The present invention provides for a method of producing a polysaccharide gel comprising: (a) culturing or growing a cyanobacterium or a mixture of cyanobacteria species in a medium under conditions such that the cyanobacterium or the mixture of cyanobacteria species produces a polysaccharide or a mixture of polysaccharides, (b) optionally separating the polysaccharide or the mixture of polysaccharides from the medium and/or the cyanobacterium or the mixture of cyanobacteria species, and (c) increasing the pH of the polysaccharide or the mixture of polysaccharides such that the polysaccharide or the mixture of polysaccharides forms a gel.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: February 2, 2021
    Assignees: The Regents of the University of California, HelioBioSys, Inc.
    Inventors: Mona Mirsiaghi, Eric Sundstrom, Deepti Tanjore, Todd Pray, Rocco L. Mancinelli, David T. Smernoff
  • Patent number: 10881631
    Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: January 5, 2021
    Assignee: ROTHAMSTED RESEARCH LTD.
    Inventors: Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
  • Patent number: 10870814
    Abstract: [Problem] Provision of a method for fractionating lipids using liquefied dimethyl ether as a solvent. [Means for Solving] To provide a method for fractionating a lipid using liquefied dimethyl ether as a solvent. [Solution] A method for fractionating a lipid, which comprises subjecting a microbial biomass to extraction using liquefied dimethyl ether as a solvent and then fractionating the lipid utilizing separation selectivity for the lipid. A method for producing a lipid, which comprises subjecting a microbial biomass to extraction using liquefied dimethyl ether as a solvent, then fractionating a portion of the lipid utilizing separation selectivity for the lipid to modify the fatty acid composition of the remainder of the lipid which remains in the microbial biomass, and then extracting the lipid having a modified fatty acid composition.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: December 22, 2020
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideki Kanda, Motonobu Goto, Yuji Okita, Eiji Ohashi
  • Patent number: 10864163
    Abstract: The invention relates to methods for attaching therapeutic agents to structures produced by thermally induced phase separation as well as methods for coating devices and producing multi-layered microspheres.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: December 15, 2020
    Assignee: UCL Business LTD
    Inventor: Richard Michael Day
  • Patent number: 10865421
    Abstract: Provided herein are novel acyltransferases and methods of using such novel acyltransferases in making medium-chain fatty acids.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 15, 2020
    Assignee: NUtech Ventures
    Inventors: Edgar Cahoon, Umidjon Iskandarov, Hae Jin Kim, Jillian Collins-Silva
  • Patent number: 10844317
    Abstract: The method of producing a lipid composition comprises an extraction treatment step to extract a lipid comprised in a hydrated raw material by using an extraction solvent comprising a polar solvent and a nonpolar solvent, and a separation treatment step to separate an extract solution obtained in the extraction treatment step into a polar solvent phase comprising a first lipid fraction and a nonpolar solvent phase comprising a second lipid fraction.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: November 24, 2020
    Assignee: IHI CORPORATION
    Inventors: Junichi Okuyama, Tomomi Yajima, Koretaro Takahashi, Takeya Yoshioka
  • Patent number: 10844411
    Abstract: The invention relates to a method for accumulating triacylglycerols in microalgae by inhibiting the sterol metabolism, by incubating the microalgae with an inhibitor of sterol metabolism. The invention also relates to a method for producing fatty acids, biofuels, pharmaceutical or cosmetic compositions, and also food supplements, comprising a triacylglycerols accumulation step in microalgae according to the invention. Finally, the invention concerns the use of an inhibitor of sterol metabolism to accumulate triglycerides in microorganisms, and preferably microalgae.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 24, 2020
    Assignees: Commissariat A L'Energie Atomique Et Aux Energies Alternatives, Centre National De La Recherche Scientifique
    Inventors: Melissa Conte, Lina-Juana Dolch, Coline Mei, Caroline Barette, Dimitris Petroutsos, Denis Falconet, Juliette Jouhet, Fabrice Rebeille, Jean-Christophe Cintrat, Eric Marechal
  • Patent number: 10821090
    Abstract: The present invention refers to new purified compositions of long chain polyunsaturated fatty acids, or their salts or esters, characterized by being essentially free from other usually present—but structurally different—components, such as furan fatty acids, phytanic and pristanic acids, squalene, and some oligomers, as well as several “persistent” environmental pollutants, such as polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans, polychlorinated biphenyls, polybrominated diphenyl-ethers, polycyclic aromatic hydrocarbons, and others, which are also usually present and extremely toxic. The invention also refers to the purification method to obtain said compositions and the use thereof as food, food for special medical use, food and diet supplement, and drug.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: November 3, 2020
    Inventor: Tiberio Bruzzese
  • Patent number: 10821411
    Abstract: A catalytic reactor comprises a filter unit which extracts and collects particles from the fluid flow stream above the reactor internals, the filter unit comprises elements which are safely, easily and quickly handled without the need for tools.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: November 3, 2020
    Assignee: Haldor Topsøe A/S
    Inventors: Klaus Risbjerg Jarlkov, Emir Zahirovic
  • Patent number: 10815506
    Abstract: A method for producing fatty acid alkyl esters, comprising providing a system comprising an oil phase/hydrophobic phase an a hydrophilic phase, and reacting a fatty acid feedstock present in said oil phase/hydrophobic phase with alcohol in the presence of water and one or more lipolytic enzymes.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 27, 2020
    Assignee: Novozymes A/S
    Inventors: Anders Rancke-Madsen, Per Munk Nielsen
  • Patent number: 10798952
    Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 13, 2020
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, Paul Warren Behrens, Jon Milton Hansen, Joseph W. Pfeifer, III, Tracey Lynn Stahl, Ross Zirkle
  • Patent number: 10787687
    Abstract: The present disclosure relates to a method for obtaining sugar and lignin fractions from lignocellulosic materials and to a method for producing fermentation products using the sugars obtained from the lignocellulose. The present disclosure also relates to a method for improving the sugar yield in the enzymatic hydrolysate by introducing a pre-treatment step of hydrothermal hydrolysis with a delignification step using a cationic compound.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: September 29, 2020
    Assignee: NESTE OYJ
    Inventors: Heidi Vainio, Olavi Myllymaki, Ville Pihlajaniemi, Mika Sipponen, Simo Laakso, Ilkka Lehtomaki, Ossi Pastinen, Perttu Koskinen
  • Patent number: 10787648
    Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: September 29, 2020
    Assignee: GENOMATICA, INC.
    Inventors: Andreas Schirmer, Baolong Zhu, Emanuela Popova
  • Patent number: 10731169
    Abstract: The present invention relates to transgenic nucleic acids, expression cassettes, vectors, plant cells, plant organs and plants. The invention also relates to methods for increasing expression or activity of a target gene, particularly in a plant cell or plant organ, and also to uses of recombinant nucleic acids and expression cassettes to increase expression or activity of a target gene or for manufacturing of a vector, plant cell, plant organ or plant. Incidentally, the invention relates to enhancers for achieving increased expression or activity of a target gene, particularly in a plant cell or plant organ, when operably linked to a promoter functional in such plant cell, plant organ or plant. The invention is described herein with reference to the technical field of production of polyunsaturated fatty acids (PUFAs), without being limited to this technical field. For the production of desired molecules in plant cells, e.g.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: August 4, 2020
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Toralf Senger, Joerg Bauer
  • Patent number: 10696924
    Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: June 30, 2020
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
  • Patent number: 10689607
    Abstract: Disclosed are an enzymatic batchwise or continuous process for the production of fatty acid alkyl esters for use in the biofuels, food and detergent industries and a system therefor. The process utilizes enzymes immobilized on a hydrophobic resin mixed with a fatty acid source and an alcohol or alcohol donor in the presence of an alkaline or mild alkaline aqueous buffer, or in the presence of water or aqueous solution. The production process for fatty acid alkyl esters is carried out by transesterification or esterification simultaneously or sequentially. The biocatalyst activity is maintained with no significant activity losses in multiple uses and also avoids the accumulation of glycerol and water by-products or other hydrophilic compounds on the biocatalyst.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: June 23, 2020
    Assignee: Trans Bio-Diesel Ltd.
    Inventors: Sobhi Basheer, Maisa Haj, Usama Mohsen, Doaa Shehadeh, Ahmad Hindawi, Emad Masoud, Ahmad Egbarieh, Ramez Masri
  • Patent number: 10662443
    Abstract: A method for producing alkane and a recombinant microorganism with good alkane productivity in a reaction system for synthesizing alkane by alkane synthase activity are provided. Alkane productivity is significantly improved in a system for synthesizing alkane by alkane synthase in the presence of ferredoxin. Specifically, the method for producing alkane according to the present invention comprises synthesizing alkane by alkane synthase in the presence of ferredoxin.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: May 26, 2020
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventor: Masaaki Mori
  • Patent number: 10640728
    Abstract: The invention discloses a method for preparing rapeseed oil by a semi-solid aqueous enzymatic process, belonging to the field of functional foods and health care products. The present invention first prepares a semi-solid rapeseed paste with 3.5-4.5% moisture content, which is hydrolyzed by a mixture of pectinase, cellulase and alkaline protease to extract rapeseed oil. The resulting rapeseed oil contains high levels of active ingredients including totaxin, sterol, phenols and beta-carotene. The rapeseed oil of the invention can be added into animal feeds, which helps to reduce animal blood lipid levels and body weight. It can significantly reduce the contents of total triglyceride, total cholesterol and LDC-C in the blood, and, at the same time, increases the level of HDL-C in the blood. In addition, the rapeseed oil prepared by the present invention can relieve hepatic steatosis in hyperlipemia rats.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: May 5, 2020
    Assignee: Jiangnan University
    Inventors: Yuanfa Liu, Peirang Cao, Jinwei Li, Liang Zhang
  • Patent number: 10633678
    Abstract: The present invention provides a process for the production of a microbial oil comprising culturing a micro-organism in a two stage fermentation process where, in a last stage that precedes the end of fermentation, the carbon source is: consumed by the micro-organisms at a rate greater than it is added to the medium; added at a rate #0.30 M carbon/kg medium; or is rate limiting on the growth of the micro-organism. The micro-organisms thus have the carbon source restricted so that they preferentially metabolise fats or lipids other than arachidonic acid (ARA), so increasing the proportion of ARA in the cells. A microbial oil is then recovered from the micro-organism, using hexane as a solvent, that has at least 50% ARA and at least 90% triglycerides.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: April 28, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Hugo Streekstra, Petrus Joseph Maria Brocken
  • Patent number: 10632047
    Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 28, 2020
    Assignee: Alcresta Therapeutics, Inc.
    Inventors: Alexey L. Margolin, Robert Gallotto, Bhami Shenoy
  • Patent number: 10620202
    Abstract: The invention provides methods and kits for the rapid confirmation of an initial analyte test result. In a preferred embodiment, the process confirms the presence of a given microbial target in a mixed culture, or a mixed enrichment media, even when the competing organisms in the mix belong to related species, or are various biotypes of the same species.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: April 14, 2020
    Assignee: Institute for Environmental Health, Inc.
    Inventor: Mansour Samadpour
  • Patent number: 10604775
    Abstract: The present invention relates to a method for producing dioic acids from a substrate containing hydrocarbons or fatty acids using a Candida infanticola strain, and to a Candida infanticola microorganism used therefor. The present invention reduces the cost increase resulting from the fluctuation in the international oil price and the burden of environmental pollution, which are caused by the use of fossil fuels, and thus can be utilized in various industrial fields using DDDA as a raw material.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: March 31, 2020
    Assignee: LOTTE CHEMICAL CORPORATION
    Inventors: Dong Myung Shin, Jong Pill Kim, Heejoon Park, Seung Hoon Lee, Hye Ran Jang, Hongweon Lee, Jung Oh Ahn, Woo Young Jeon, Gyu Yeon Park, Hee Suk Lee
  • Patent number: 10596121
    Abstract: Medicaments and therapeutic compositions comprise Red Yeast Rice extract and omega-3 polyunsaturated fatty acids and/or derivatives thereof, e.g., DHA, derivatives of DHA, EPA, derivatives of EPA or mixtures thereof. One source of the fatty acids or derivatives thereof is fish oil. The compositions are useful for lowering cholesterol and/or triglyceride levels in a subject.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 24, 2020
    Assignee: NORDIC NATURALS, INC.
    Inventor: Joar Opheim
  • Patent number: 10597630
    Abstract: Disclosed is a method for culture of microalgae, advantageously of the genus Crypthecodinium having a gene coding for the small 18s ribosomal RNA subunit having a genetic similarity of at least 96% with the same gene of the strain of the species Crypthecodinium cohnii deposited in the CCAP (Culture Collection of Algae and Protozoa) under number CCAP 1104/3 in a defined chemical medium.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: March 24, 2020
    Assignee: FERMENTALG
    Inventors: Pierre Calleja, Cyril Rols, Julien Pagliardini, Brice Bourdenx
  • Patent number: 10595546
    Abstract: A novel method of reducing the melting point of a peptide-based biopolymer using a nitrogen-containing compound as a plasticizer is provided. The peptide-based biopolymer can be keratin or silk. The nitrogen-containing compound can be one or more amino acids or other nitrogen-containing compounds (except urea), all of which have a melting temperature above approximately 133° C., the decomposition temperature of urea. Pellets made using this novel process can be used as animal feed and soil amendments (fertilizer) to increase the adsorption of amino acids in the animal or in the soil, respectively.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 24, 2020
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: Walter F. Schmidt
  • Patent number: 10570427
    Abstract: The invention provides methods and systems for the production of lipid products from a gaseous substrate using a two stage fermentation process. The method comprises providing a gaseous substrate comprising CO, CO2 or H2 or mixtures thereof, to a first bioreactor containing a culture or one or more microorganisms, and fermenting the substrate to produce acetate. The acetate from the first bioreactor is then provided to a second bioreactor, where it is used as a substrate for fermentation to lipids by one or more microalgae.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: February 25, 2020
    Assignees: LANZATECH NEW ZEALAND LIMITED, DBT-IOC Centre for Advanced Bio-Energy Research
    Inventors: Sean Dennis Simpson, Sebastian Michal Bernasek, Deepak K Tuli
  • Patent number: 10562943
    Abstract: The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant L. acidophilus cells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinant L. acidophilus cells or SlpA isolated from L. acidophilus can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: February 18, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Yaima L. Lightfoot, Bikash Sahay, Mansour Mohamadzadeh
  • Patent number: 10557114
    Abstract: The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.
    Type: Grant
    Filed: October 8, 2017
    Date of Patent: February 11, 2020
    Assignee: CORBION BIOTECH, INC.
    Inventors: George N. Rudenko, Jason Casolari, Scott Franklin
  • Patent number: 10550402
    Abstract: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD3A, FAD3B, and FAD3C genes.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: February 4, 2020
    Assignee: CELLECTIS
    Inventors: Luc Mathis, Zachary Demorest, Feng Zhang, William Haun
  • Patent number: 10538793
    Abstract: Provided is ?3 desaturase having high enzymatic activity even at normal temperature. A polypeptide which consists of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and has ?3 desaturation activity on C20 fatty acid, and a gene thereof.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: January 21, 2020
    Assignees: KYOTO UNIVERSITY, NISSHIN PHARMA INC.
    Inventors: Jun Ogawa, Akinori Ando, Eiji Sakuradani, Sakayu Shimizu, Shigeru Hiramoto, Masataka Harata, Yuki Takemoto
  • Patent number: 10538788
    Abstract: Methods and compositions for synthesizing dienes and derivative thereof, such as isoprene, in Cupriavidus necator are provided.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: January 21, 2020
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Stephen Thomas Cartman, Alexander Brett Foster, Ana Teresa dos Santos Brito Mendes Roberts, Mark Paul Taylor
  • Patent number: 10519453
    Abstract: Methods and engineered yeast cells for generating a benzylisoquinoline alkaloid product are provided herein. A method comprises providing engineered yeast cells and a feedstock to a reactor. In the reactor, the engineered yeast cells are subjected to fermentation by incubating the engineered yeast cells for a time period to produce a solution comprising the BIA product and cellular material. The solution comprises not more than one class of molecule selected from the group of protoberberine, morphinan, isopavine, aporphine, and benzylisoquinoline. Additionally, at least one separation unit is used to separate the BIA product from the cellular material to provide the product stream comprising the BIA product.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: December 31, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christina D. Smolke, Catherine Thodey, Isis Trenchard
  • Patent number: 10519050
    Abstract: A method for reducing the amount of acrylamide in recovered water from a fryer stack. This invention provides a method to treat acrylamide in the waste water/process water. Organic compounds such as phenols, acrylamide and phenolic compounds can be oxidized in the presence of oxidizing compounds like hypo and Fenton reagent. Fenton reagent is a product of reaction of Iron Salts (like Ferrous Sulphate-FeSO4) and Hydrogen Peroxide (H2O2). It generates OH* (radical) which has significantly more oxidation power compared to traditional oxidizing agents such as Chlorine. The fryer stack water is collected and treated using Fenton reagent such that the Acrylamide levels are reduced to less than 0.1 ppb in the recovered water.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 31, 2019
    Assignee: Frito-Lay North America, Inc.
    Inventors: Ashish Anand, Siva Kumar Kota, Rravindar Verma
  • Patent number: 10513716
    Abstract: The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: December 24, 2019
    Assignee: Genomatica, Inc.
    Inventors: Robin E. Osterhout, Anthony P. Burgard
  • Patent number: 10513718
    Abstract: A method of producing a polyunsaturated fatty acid in a transgenic bacterium, includes: introducing a recombinant plasmid into a bacteria cell to obtain the transgenic bacterium, wherein the recombinant plasmid comprises a polynucleotide encoding one or more elongase and one or more desaturase; incubating the transgenic bacterium in a medium containing a fatty acid substrate; harvesting the transgenic bacterium, and extracting the polyunsaturated fatty acid from the transgenic bacterium. A method of converting linoleic acid to arachidonic acid and a cassette and recombinant plasmid comprising nucleic acid sequences for the above methods are also provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: December 24, 2019
    Assignee: City University of Hong Kong
    Inventors: Lok Man So, Man Chak Tse, Kai Kin Chi, Yuen Chong Kong, Sin Yu Yeung
  • Patent number: 10508292
    Abstract: A method of producing a lipid, containing the steps of culturing a transformant obtained by introducing a gene encoding the following protein (a) or (b) into cyanobacteria, and producing a lipid: (a) a protein consisting of the amino acid sequence set forth in SEQ ID NO: 1; and (b) a protein consisting of an amino acid sequence having 60% or more identity with the amino acid sequence of the protein (a), and having ?-ketoacyl-ACP synthase activity.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: December 17, 2019
    Assignee: Kao Corporation
    Inventors: Akihito Kawahara, Shinji Sugihara
  • Patent number: 10472643
    Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: November 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Chia-Lin Wei, Chew Yee Ngan, Chee Hong Wong, Cindy Choi