Lactic Acid Patents (Class 435/139)
  • Patent number: 11485690
    Abstract: The present technology relates to a method for preparing a mixture of solid potassium salts from a fermentation juice from a fermentation process for the production of chemical compounds in a pH-controlled fermentation medium by adding of a base comprising potassium hydroxide. The method comprises adding an acid to the fermentation juice in an amount sufficient to cause the precipitation of the mixture of potassium salts, and then separating the mixture of salts of potassium solid potassium acidified fermentation juice. The present technology also relates to the mixture of potassium salts obtained by said method and its use as fertilizer.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 1, 2022
    Assignee: AFYREN
    Inventors: Jeremy Jean-Paul Pessiot, Michael Fréderic Pierre Roussel, Aurelien Antoine Bost
  • Patent number: 11401536
    Abstract: The present invention provides a method of preparing D-psicose comprising the steps of (i) providing a mixture of D-psicose and D-fructose; and (ii) contacting the mixture of D-psicose and D-fructose with a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid and subjecting the microorganism to culture conditions that allow fermentative removal of D-fructose from the mixture of D-psicose and D-fructose with concomitant production of L-lactic acid. Further provided are uses of a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid for fermentative removal of D-fructose from a mixture of D-psicose and D-fructose. In particular, the probiotic microorganism is Lactobacillus rhamnosus GG or Saccharomyces boulardii.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: August 2, 2022
    Assignee: NGEE ANN POLYTECHNIC
    Inventors: Xingding Zhou, Ling Jie Stephanie Lee
  • Patent number: 11390891
    Abstract: Methods and materials related to producing D-lactic acid are disclosed. Specifically, isolated synthetic or natural nucleic acids, synthetic or natural polypeptides, host cells, and methods and materials for producing D-lactic acid by direct fermentation from carbon sources are disclosed, along with methods of preparing D-lactic acid polymers.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: July 19, 2022
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Mario Ouellet, Andrew Jonathan Conley
  • Patent number: 11382335
    Abstract: A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate comprising calcium and phosphate, and separating the precipitate from the whey by-product to provide a clarified whey by-product. The clarified whey by-product is fermentated by a bacterium capable of bioconversion of lactose to lactic acid to provide a fermentation broth containing a lactic acid salt. In the downstream steps, the fermentation broth is acidified to release lactic acid from the lactic acid salt, precipitate from the broth produced by acidification is removed, and the acidified fermentation broth is treated to recover pure lactic acid by removal of residual salts, and water, and optionally protein.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: July 12, 2022
    Assignee: GLANBIA IRELAND DAC
    Inventors: Bill Morrissey, Colm O'Brien, Magda Hogan, Eamon Hogan, Parikshit Rameshwar Sawdekar, Ramesh Babu Padamati
  • Patent number: 11248206
    Abstract: The present invention discloses a bacterium and an obtaining method and application thereof. The bacterium has a property of coproducing 1,3-propanediol and D-lactic acid. Further, the bacterium is Klebsiella oxytoca, including Klebsiella oxytoca PDL-5 CCTCC M 2016185. The obtaining method of the bacterium may be to obtain the bacterium by directly screening wild bacteria that satisfy conditions from the environment or performing gene engineering modification to wild bacteria. The present invention has the advantages that the bacteria can coproduce 1,3-propanediol and D-lactic acid through fermentation, the molar conversion rate and the concentration of the two products are very high, the types of byproducts are few, the concentration is low, the product extraction process is simplified, the high-efficiency biological production of 1,3-propanediol and D-lactic acid can be realized, and the industrial application prospect is very great.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: February 15, 2022
    Assignee: Shanghai Jiao Tong University
    Inventors: Ping Xu, Bo Xin, Fei Tao, Yu Wang, Hongzhi Tang, Cuiqing Ma
  • Patent number: 11248221
    Abstract: The present disclosure relates to an enzyme complex of arabinose isomerase, agarase and 3,6-anhydro galactosidase and a method for producing tagatose by degrading agar using the same. By using the enzyme complex according to the present disclosure, agar obtained from marine biomass can be degraded effectively and useful physiologically active substances such as tagatose can be obtained effectively therefrom.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: February 15, 2022
    Assignee: Korea University Research and Business Foundation
    Inventors: Sung Ok Han, Da-Woon Jeong, Jeong Eun Hyeon
  • Patent number: 11220665
    Abstract: Provided is a method for producing a high-density filamentous fungal pellet. A method for producing a filamentous fungal pellet, comprising a step of germinating spores of a filamentous fungus in a culture medium containing a cationic polymer.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: January 11, 2022
    Assignee: KAO CORPORATION
    Inventors: Takeshi Sakamoto, Yutaka Irie
  • Patent number: 11214809
    Abstract: A vector is provided that includes a nucleotide sequence selected from any one of (a) to (d). The selection of (a) to (d) includes: (a) the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21, (b) the nucleotide sequence complementary to the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21, where (a) and (b) hybridize under stringent conditions, (c) the nucleotide sequence having 90% or more sequence identity with the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21, and (d) the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21 in which a total of 1 to 50 nucleotides are substituted, deleted, or inserted.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 4, 2022
    Assignee: KANEKA CORPORATION
    Inventors: Teruyuki Nishi, Tozo Nishiyama, Toru Watanabe, Yuji Okubo
  • Patent number: 11136602
    Abstract: A fermentation product manufacturing process includes fermenting under fermentation conditions in an aqueous fermentation medium in a fermentation reactor a carbohydrate source with a microorganism capable of converting the carbohydrate into a fermentation product which is a salt or a product with a boiling point above the boiling point of water, during the process withdrawing part of the medium including biomass from the reactor in the form of a recycle stream, providing the stream including biomass to a pressure vessel wherein the pressure is such that the temperature of the stream decreases 1-8° C., as compared to the temperature of the medium in the reactor, by the evaporation of water, and recycling the cooled recycle stream to the reactor. The process makes it possible to obtain a homogeneous temperature profile of the fermentation medium with limited occurrence of hot or cool spots within the reactor which results in improved fermentation performance.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 5, 2021
    Assignee: PURAC BIOCHEM BV
    Inventors: Andre Banier De Haan, Jeroen Bokhove
  • Patent number: 11034982
    Abstract: Improved yeast cell with increased succinic acid production based on yield and titer. Increased activity of one or more enzymes involved in the pentose phosphate pathway, reducing flux through phosphoglucose isomerase, increasing flux to cytoplasmic acetyl-CoA, installation of a malic enzyme, and/or installation of a formate dehydrogenase leads to increased production of succinic acid.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: June 15, 2021
    Assignee: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED
    Inventor: Ryan Sillers
  • Patent number: 10900016
    Abstract: Disclosed are methods and systems for propagating microorganisms such as yeast using a carbon source that includes glycerol and a nutrient source that includes a stillage component.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: January 26, 2021
    Assignee: POET Research, Inc.
    Inventors: Neelakantam V. Narendranath, Stephen M. Lewis
  • Patent number: 10899544
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: January 26, 2021
    Assignee: CARGILL, INCORPORATED
    Inventors: Catherine Asleson Dundon, Pirrko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Patent number: 10883121
    Abstract: The present disclosure is related to a process comprising steps of fermentation, separation and purification that can be carried out in a centralized facility with large scale fermentation or in a decentralized facility with smaller scales of fermentation to make value added products from substrate not limiting to gaseous substrates effectively. The fermentation involves fermentative production of a marketable product using reactors or fermentors which are optimized for influential parameters such as gaseous substrate, gas hold up, mass transfer coefficient, etc. The separation step involves an effective way of separating desired product from fermentation broth by employing filtration, precipitation or adsorption techniques thereby enabling easy transportation of the product in case of a decentralized facility. The final stage of the process, either in centralized or decentralized facility, includes the elution of retained product and further purification of the same using downstream processing techniques.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: January 5, 2021
    Assignee: STRING BIO PRIVATE LIMITED
    Inventors: Ezhil Subbian, Karthikeyan Thillai, Divakar Duraiswami, Vinod Munisanjeeviah Lakshmi Devi Kumar, Naga Sairam, Purvesh Girdharbhai Shingala, Sandeep Kumar Chavana
  • Patent number: 10850990
    Abstract: Magnesium chloride solutions including providing aqueous magnesium chloride solution with magnesium chloride concentration of 10-30 wt. % to concentration step where water is evaporated, resulting in concentrated magnesium chloride solution with magnesium chloride concentration of 30-50 wt. %, wherein concentration step is carried out in one or more stages, wherein at least one of the stages is conducted at elevated pressure, withdrawing concentrated magnesium chloride solution from concentration step, and providing it to thermohydrolysis reactor of at least 300° C., withdrawing MgO from thermohydrolysis reactor in solid form, and withdrawing a HCl containing gas stream of at least 300° C. from thermohydrolysis reactor, providing the HCl-containing gas stream of at least 300° C. to cooling step, where HCl-containing gas stream is contacted with cooling liquid, withdrawing HCl-containing gas stream below 150° C.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: December 1, 2020
    Assignee: PURAC BIOCHEM BV
    Inventors: Johannes Jeichienus De Vries, Raymon Frediansyah
  • Patent number: 10731186
    Abstract: The invention relates to a genetically engineered thermophilic bacterial cell that is facultative anaerobic comprising: a) inactivation or deletion of the endogenous (S)-lactate dehydrogenase gene; b) introduction of a (R)-lactate dehydrogenase gene; c) inactivation or deletion of the endogenous pyruvate formate lyase A and/or B gene.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: August 4, 2020
    Assignee: PURAC BIOCHEM BV
    Inventors: Marinus Petrus Machielsen, Mariska Van Hartskamp, Richard Van Kranenburg
  • Patent number: 10731184
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. The yeast has an exogenous invertase gene and has a deletion or disruption of the PDC activity gene. Accordingly, the yeast is useful for manufacturing fermentation products other than ethanol from fermentation substrates containing sucrose.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 4, 2020
    Assignee: CARGILL, INCORPORATED
    Inventors: Arlene M. Fosmer, Peter Alan Jauert, Gregory M. Poynter, Brian J. Rush
  • Patent number: 10597662
    Abstract: The present invention relates to a transformant which uses Schizosaccharomyces pombe as a host into which a D-LDH gene derived from bacteria of the genus Pediococcus and a D-LDH gene derived from bacteria of the genus Lactobacillus are incorporated and in which some of the genes in a group of pyruvate decarboxylase-encoding genes of the Schizosaccharomyces pombe host have been deleted or inactivated.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: March 24, 2020
    Assignee: JMTC Enzyme Corporation
    Inventors: Futoshi Hara, Shuichiro Kimura, Yuichiro Hagiya, Takayuki Tanaka
  • Patent number: 10501761
    Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as hydroxy-carboxylic acids and hydroxy-carboxylic acid derivatives. A method includes treating a reduced recalcitrance lignocellulosic or cellulosic material with one or more enzymes and/or organisms (such as lactobacillus, Pediococcus, Rhizopus, Enterococcus) to produce an alpha, beta, gamma and/or delta hydroxycarboxylic acid (such as lactic acid, glycolic acid); and converting the alpha, beta, gamma and/or delta hydroxy-carboxylic acid to the product (such as esters, polymers, and copolymers).
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: December 10, 2019
    Assignee: Xyleco, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Andrew Papoulis, Jaewoong Moon, Jihan Khan, Robert Paradis
  • Patent number: 10214754
    Abstract: Provided is a transformant which can produce lactic acid with a high productivity without requiring neutralization with an alkali and is excellent in both of lactic acid production capability and growth ability and its production process, and a method for producing lactic acid by using the transformant. A transformant comprising 3 copies of a human lactate dehydrogenase gene that is introduced into a Schizosaccharomyces pombe host, wherein a gene encoding pyruvate decarboxylase 2 of the Schizosaccharomyces pombe host is deleted or inactivated.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: February 26, 2019
    Assignee: JMTC Enzyme Corporation
    Inventors: Futoshi Hara, Ayako Kashima, Shuichiro Kimura
  • Patent number: 10190076
    Abstract: The present invention relates generally to corn dry-milling, and more specifically, to methods for producing a high protein corn meal from a whole stillage byproduct produced in a corn dry-milling process for making ethanol and a system therefore. In one embodiment, a method for producing a high protein corn meal from a whole stillage byproduct includes, in a corn dry-milling process for making ethanol, separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion. The thin stillage portion is separated into a protein portion and a water soluble solids portion. Next, the protein portion is dewatered then dried to define a high protein corn meal that includes at least 40 wt % protein on a dry basis.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 29, 2019
    Assignee: Fluid Quip, Inc.
    Inventor: Chie Ying Lee
  • Patent number: 10190769
    Abstract: The invention provides a process for the conversion of biomass into a biomass product which is suitable for use as a fuel. The biomass is of plant origin and comprises microorganisms naturally occurring in the biomass. The process comprises—preparing a slurry by dispersing the biomass comprising the naturally occurring microorganisms in an aqueous liquid, maintaining the slurry at conditions suitable for aerobic digestion by the microorganisms to obtain a slurry comprising the biomass product as a dispersed solid phase, and—recovering the biomass product. The recovering comprises washing and drying the biomass product. The invention also provides a combustion process.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: January 29, 2019
    Assignee: NEWFOSS HOLDING B.V.
    Inventors: Dirk Jan Vos, Simon Rustenburg
  • Patent number: 10160932
    Abstract: The present invention relates generally to corn dry-milling, and more specifically, to methods for producing a high protein corn meal from a whole stillage byproduct produced in a corn dry-milling process for making ethanol and a system therefore. In one embodiment, a method for producing a high protein corn meal from a whole stillage byproduct includes, in a corn dry-milling process for making ethanol, separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion. The thin stillage portion is separated into a protein portion and a water soluble solids portion. Next, the protein portion is dewatered then dried to define a high protein corn meal that includes at least 40 wt % protein on a dry basis.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: December 25, 2018
    Assignee: Fluid Quip, Inc.
    Inventor: Chie Ying Lee
  • Patent number: 10155967
    Abstract: The present invention relates to Saccharomyces sp. capable of producing lactic acid with a decreased activity of pyruvate decarboxylase (PDC) and increased activities of aldehyde dehydrogenase (ALD) and acetyl-CoA synthetase (ACS), and a method of producing lactic acid from the culture medium obtained by culturing the microorganism.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: December 18, 2018
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Eun Bin Yang, Tae Hee Lee, Seon Hye Kim, Gyuhyeon Song, Cheol Woong Ha, Kyungsu Na, Young Lyeol Yang, Min Sun Kang, Hyo Hyoung Lee
  • Patent number: 10072117
    Abstract: A method of producing lactic acid includes removing glycerol from an aqueous lactic acid solution containing glycerol as an impurity using an ion-exchange resin. The lactic acid can be separated simply and at low cost from an aqueous lactic acid solution containing glycerol as an impurity.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: September 11, 2018
    Assignee: Toray Industries, Inc.
    Inventors: Kenji Kawamura, Masateru Ito, Katsushige Yamada
  • Patent number: 10000537
    Abstract: The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 ?3 and a side chain hydrophobicity of 10 to 100 ?tR.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 19, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Klaassen, Paulus Petrus De Waal, Rene Marcel De Jong, Arnold Jacob Mattieu Driessen, Jeroen Gerben Nijland, Hyun Yong Shin
  • Patent number: 9994877
    Abstract: Provided are a genetically engineered yeast cell having increased activity of SUL1, STR3, HXT7, ERR1, GRX8, MXR1, GRE1, MRK1, AAD10 or a combination thereof, compared to a parent cell, and also having acid tolerance, a method of preparing the same, and a method of producing lactate using the same.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: June 12, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Soonchun Chung, Jinha Kim, Kwangmyung Cho
  • Patent number: 9961914
    Abstract: The present invention discloses a method to prepare a fruit ferment containing propionic acid and/or a salt thereof comprising i) obtaining a liquid fruit preparation, ii) optionally supplementing the liquid fruit preparation with water and/or with additional components to support fermentation, iii) fermenting the optionally supplemented liquid fruit preparation with a propionic acid-producing bacterial strain, iv) optionally further processing the fermentation product, to obtain the fruit ferment. Next to a propionic acid-producing bacterial strain, a lactic acid-producing bacterial strain may be used in the fermentation. The invention also relates to a fruit ferment obtainable by said method and the use in a food, beverage, as a probiotic and to improve the sensory properties and/or the storage stability is also disclosed.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: May 8, 2018
    Assignee: PURAC BIOCHEM BV
    Inventors: Arne Olav Sliekers, Eelco Anthonius Johannes Heintz
  • Patent number: 9949486
    Abstract: The invention relates to an agrochemical composition containing a compound of formula (1), a glutamic acid compound, and a source of magnesium and/or a source of iron. The composition applied e.g. foliarly has demonstrated synergistic benefits that improve crop yields and quality characteristics.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: April 24, 2018
    Assignee: Crop Intellect Ltd.
    Inventor: Apostolos Papadopoulos
  • Patent number: 9885067
    Abstract: A recombinant yeast cell having a decreased RGT1 protein activity and an increased ability to produce a glycolytic intermediate or a glycolytic intermediate-derived substance, compared to a parent cell; methods of producing the same; and methods of producing the glycolytic intermediate or the glycolytic intermediate-derived substance using the same.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: February 6, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jinsuk Lee, Changduk Kang, Seunghyun Lee, Kwangmyung Cho
  • Patent number: 9796896
    Abstract: Fertilizers and fertilizer additive compositions and methods are provided. The compositions and methods comprise utilizing by-products from the manufacture of biodiesel and/or fatty alkyl esters, wherein the by-product comprises glycerin, mong, moisture, C6-C24 saturated and unsaturated fatty acids, C6-C24 saturated and unsaturated fatty acid salts, methyl esters, ethyl esters and combinations thereof.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 24, 2017
    Inventors: Joan Lynch, Bo Tran
  • Patent number: 9745560
    Abstract: The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as Saccharomyces cerevisiae. In some embodiments, this invention provides for the engineering of a series of biocatalysts combining the expression and secretion of components of this enzymatic system with robust, rapid xylose utilization, and ethanol fermentation under industrially relevant process conditions for consolidated bioprocessing. In some embodiments, the invention utilizes co-cultures of strains that can achieve significantly improved performance due to the incorporation of additional enzymes in the fermentation system.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 29, 2017
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: John E. McBride, Erin Wiswall, Indraneel Shikhare, Haowen Xu, Naomi Thorngren, Heidi H. Hau, Emily Stonehouse
  • Patent number: 9677098
    Abstract: A yeast cell capable of producing lactate, a method of preparing the yeast cell, and a method of producing lactate by using the yeast cell, wherein theyeast cell has a reduced activity of rim15 protein, igo2 protein, or a combination thereof, and an increased activity of an enzyme that catalyzes conversion from pyruvate to lactate, compared to a parent cell.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: June 13, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Juyoung Lee, Changduk Kang, Jiyoon Song, Seunghyun Lee, Jinhwan Park, Kwangmyung Cho
  • Patent number: 9604895
    Abstract: A process for producing lactic acid is provided. The process comprises (a) reacting a stream rich in saccharide with sodium hydroxide in the presence of water to produce a reaction mixture comprising sodium lactate; (b) reacting at least a portion of the sodium lactate with HCl to produce lactic acid and sodium chloride; (c) converting at least a portion of the sodium chloride to chlorine and sodium hydroxide; and (d) recycling at least a portion of the sodium hydroxide produced in step (c) to step (a). Also provided are processes for the production of alkyl lactate, oligomeric lactic acid, lactide, alkyl lactyllactate, poly-lactic acid, propylene glycol and acrylic acid.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: March 28, 2017
    Assignee: Plaxica Limited
    Inventors: Stephen Donegan, Philip James Goodier, Edward Leslie Marshall, Urvish Rameshchandra Pandya, Ajitkumar Mukundrai Patel
  • Patent number: 9598709
    Abstract: Provided is a yeast cell having a stress tolerance, wherein the yeast cell has enhanced MSN2 activity, a method of producing the yeast cell, and a method of producing lactate by using the same.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: March 21, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sungsoo Kim, Sunghaeng Lee, Dongsik Yang, Huisub Lim, Kwangmyung Cho
  • Patent number: 9562243
    Abstract: A yeast cell with reduced pyruvate to oxaloacetate conversion activity, and a method of producing lactate using the yeast cell.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 7, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Youngkyoung Park, Changduk Kang, Jiyoon Song, Juyoung Lee, Seunghyun Lee, Kwangmyung Cho
  • Patent number: 9528132
    Abstract: The present invention relates to a polynucleotide encoding a recombinant scaffolding polypeptide comprising at least a signal peptide, a Cellulose Binding Domain, two cohesin domains and an S-layer Homology domain, wherein said isolated polynucleotide preferably comprises all or an active part of the nucleotide sequence as set forth in SEQ ID NO:2. The present invention further relates to vectors comprising such polynucleotides, recombinant lactic acid bacteria, and method for degrading a cellulosic biomass using such recombinant lactic acid bacteria.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: December 27, 2016
    Assignee: CARBIOS
    Inventors: Roberto Mazzoli, Enrica Pessione, Loredana Tarraran, Chiara Gandini
  • Patent number: 9499822
    Abstract: A simple and inexpensive method for selectively culturing a microorganism which method makes it possible to selectively culture a microorganism of interest even without using a sterilization operation or an antibiotic substance is provided. The method according to the present invention selectively culturing a microorganism includes the step of culturing, in a culture medium containing phosphorous acid as a sole phosphorous source, a recombinant microorganism into which a phosphite dehydrogenase gene has been introduced.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: November 22, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Akio Kuroda, Ryuichi Hirota, Takenori Ishida
  • Patent number: 9428773
    Abstract: The present disclosure provides recombinant cyanobacteria having acetolactate synthase activity and acetolactate decarboxylase activity, as well as recombinant cyanobacteria having acetolactate synthase activity, acetolactate decarboxylase activity, and secondary alcohol dehydrogenase activity. Methods for the production of the recombinant cyanobacteria, as well as methods for use thereof for production of acetoin and 2,3-butanediol from carbon dioxide and light are also provided.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: August 30, 2016
    Assignee: The Regents of the University of California
    Inventors: Shota Atsumi, John W. K. Oliver, Iara M. P. Machado
  • Patent number: 9428777
    Abstract: Objects of the present invention are to provide a transformant which can produce lactic acid with high productivity without requiring neutralization with an alkali, a method for producing the same, and a method for producing lactic acid by using the transformant. Namely, they are a transformant, in which Schizosaccharomyces pombe is used as a host, a lactate dehydrogenase gene of Lactobacillus pentosus is introduced, and a part of a gene cluster encoding a pyruvate decarboxylase in the Schizosaccharomyces pombe host is deleted or inactivated; a method for producing the transformant; and a method for producing lactic acid by using the transformant.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: August 30, 2016
    Assignee: ASAHI GLASS COMPANY, LIMITED
    Inventors: Futoshi Hara, Shuichiro Kimura
  • Patent number: 9416222
    Abstract: Disclosed is a test and test apparatus used to determine whether lactic acid is suitable for polymerization. The test apparatus comprises a) means for the polycondensation of the lactic acid to form a pre-polymer, b) means for depolymerization of the prepolymer to form dilactide, and c) means for carrying out analytical methods to determine at least one of the dilactide yield and/or the racemization, wherein lactic acid which is suitable for polymerization exhibits a dilactide yield of >90% and a racemization of <5%.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: August 16, 2016
    Assignees: THYSSENKRUPP INDUSTRIAL SOLUTIONS AG, UHDE INVENTA-FISCHER GMBH
    Inventors: Joachim Schulze, Rainer Hagen, Wolfgang Tietz, Shashank Ghanegaonkar
  • Patent number: 9416380
    Abstract: A yeast cell comprising LDH from a Sordaria genus fungi, in which activity of lactate dehydrogenase converting pyruvate into lactate is increased, as well as a method of preparing the yeast cell and a method of using the yeast cell to produce lactate.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: August 16, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sung-soo Kim, So-young Lee, Chang-duk Kang, Ju-young Lee, Kwang-myung Cho
  • Patent number: 9365869
    Abstract: A process for increasing a production of alcohol by fermenting sugars may include applying a direct current electrical field to a fermentation broth, which occurs before the fermentation broth inoculates with a concentration of yeasts; and controlling a pH value of said fermentation broth to maintain the pH value with a specific range.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: June 14, 2016
    Assignee: ADVEL TECNOLOGIA E COMERCIA LTDA.
    Inventor: José Francisco Lopes
  • Patent number: 9346843
    Abstract: The present invention relates to a process for generating glucose and glucose derivatives from the direct contacting of cellulose, hemicelluloses and/or polysaccharides with a mixed super critical fluid system of alcohol and water whereby the partial pressure of the system provides for both alcoholysis and hydrolysis of the material to generate primarily glucose, and glucose derivatives.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 24, 2016
    Assignee: Inventure Renewables, Inc.
    Inventors: William Rusty Sutterlin, Mark G. Tegen, William Berry
  • Patent number: 9340807
    Abstract: A polypeptide conferring an acid-tolerant property on a yeast cell, a polynucleotide encoding the polypeptide, a yeast cell including an increased amount of the polypeptide, a method of producing a product by using the yeast cell, and a method of producing an acid-tolerant yeast cell are provided.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: May 17, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Woo Yong Lee, Chang Duk Kang, Ju Young Lee, Kwang Myung Cho
  • Patent number: 9315834
    Abstract: Provided is a method for producing xylonic acid from xylose with a recombinant fungal strain that is genetically modified to express a xylose dehydrogenase gene, which is able to convert xylose to xylonolactone, which is spontaneously or enzymatically hydrolyzed to xylonic acid. The xylonic acid is excreted outside the host cell. Xylonate production may be coupled with xylitol production. Alternatively, if xylitol production is not desired, its production is reduced by removing the aldose reductase (or specific xylose reductase) enzyme, which converts xylose to xylitol. Expression of a heterologous lactonase encoding gene may result in higher acid concentrations. The method is suitable for producing xylonic acid from a hemicellulose hydrolysate such as hydrolyzed lignocellulosic plant biomass.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: April 19, 2016
    Assignee: Teknologian Tutkimuskeskus VTT
    Inventors: Peter Richard, Marilyn Wiebe, Mervi Toivari, Dominik Mojzita, Laura Ruohonen, Merja Penttilä
  • Patent number: 9294498
    Abstract: Determining an entity's cybersecurity risk and benchmarking that risk includes non-intrusively collecting one or more types of data associated with an entity. Embodiments further include calculating a security score for at least one of the one or more types of data based, at least in part, on processing of security information extracted from the at least one type of data, wherein the security information is indicative of a level of cybersecurity. Some embodiments also comprise assigning a weight to the calculated security score based on a correlation between the extracted security information and an overall security risk determined from analysis of one or more previously-breached entities in the same industry as the entity. Additional embodiments include calculating an overall cybersecurity risk score for the entity based, at least in part, on the calculated security score and the weight assigned to the calculated security score.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: March 22, 2016
    Assignee: SecurityScorecard, Inc.
    Inventors: Aleksandr Yampolskiy, Rob Blackin, Alexander Heid, Samuel Kassoumeh
  • Patent number: 9284519
    Abstract: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of the cultivation support. Devices for the large scale and continuous cultivation of photosynthetic microorganisms incorporating photobioreactors and methods of use are disclosed. Also disclosed are methods of producing fermentable sugar from photosynthetic microorganisms using a photobioreactor of the invention.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: March 15, 2016
    Assignee: Proterro, Inc.
    Inventors: John Aikens, Robert J. Turner
  • Patent number: 9238618
    Abstract: Processes for the production of polyols from sources such as dried distillers grains plus solubles (DDGS) make use of a two-stage reaction scheme. In the first stage, the proteinaceous starting material is reacted with an aminating agent, such as diethanolamine (DEOA), to generate amino-amides and amides. These products are then reacted with an alkoxylating agent, preferably a substituted or unsubstituted epoxide to yield polyols. These polyols may be further reacted with isocyanates to give low-cost rigid polyurethane foams. In alternate forms, lignin may be directly converted to polyols by reaction with an alkoxylating agent, optionally followed by reaction with an isocyanate to produce polyurethanes.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: January 19, 2016
    Assignees: MGPI Processing, Inc., Pittsburg State University
    Inventors: Sukh Bassi, Michael Douglas Parker, Mihail Ionescu, Zoran Petrovic
  • Patent number: 9228167
    Abstract: In a method for controlling the growth of microbes grown in a medium to high cell-densities by the fed-batch technology, a two-phase system, having a liquid phase (cultivation medium) and a solid or gel phase, the solid or gel phase provides a source of substrate-delivering polymer which is turned by an enzyme in a controlled way into a growth-limiting substrate or pH adjusting agent. Also described is a method for restricting the synthesis of growth-limiting metabolites and preventing oxygen-depletion in microbial cell cultures.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: January 5, 2016
    Assignee: OULUN YLIOPISTO
    Inventors: Antti Vasala, Peter Neubauer, Johanna Panula-Perala
  • Patent number: 9200297
    Abstract: An isolated biologically pure culture of Clostridium tyrobutyricum ITRI04001 or an isolated biologically pure culture of Clostridium tyrobutyricum having the genotypic characteristics of ITRI04001 useful for syngas fermentation. Volatile free acids are produced by a method comprising culturing a microorganism having the genotypic characteristics of ITRI04001 in a medium; providing at least one substrate comprising at least one carbon source chosen from CO and CO2 to the microorganism; and recovering at least one free volatile free acid. Syngas can be the at least one substrate in these processes for producing volatile free acids.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: December 1, 2015
    Assignee: GREEN CELLULOSITY CORPORATION
    Inventors: Chang-Chieh Chen, Yi-Te Chou, Shao-Wen Wu, Shi-Chan Tseng, Hsin-Tzu Kuo, Wan-Ting Ma