Cyclopentanone Or Cyclopentadione Containing Compound Patents (Class 435/149)
  • Publication number: 20130045513
    Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 21, 2013
    Applicant: BASF SE
    Inventors: Stephan Maurer, Bernhard Hauer, Melanie Bonnekessel, Kurt Faber, Clemens Stückler
  • Patent number: 8323936
    Abstract: The invention relates to a process for the enantioselective enzymatic reduction of secodione derivatives. The secodione derivative is reduced with an oxidoreductase/dehydrogenase in the presence of NADH or NADPH as a cofactor. The secodione derivative is used in the reaction batch at a concentration of ?10 g/l and the oxidized cofactor NAD or NADP formed by the oxidoreductase/dehydrogenase is regenerated continuously.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: December 4, 2012
    Assignee: IEP GmbH
    Inventors: Antje Gupta, Anke Tschentscher, Maria Bobkova
  • Publication number: 20120283097
    Abstract: Provided are pesticidal compositions comprising 4,5-dihydroxyindan-1-one or derivatives thereof for protecting important crops against mites, fungi, and bacteria. The compositions may be manufactured by fractionating fungal extracts.
    Type: Application
    Filed: September 13, 2010
    Publication date: November 8, 2012
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Abraham Sztejnberg, Uri Gerson, Zahi Paz, Zohar Kerem, Izhak Bilkis
  • Patent number: 8192966
    Abstract: A novel label-free sensitive detection method by employing a novel sensitive charge sensor is provided. Dissociation constant information is provided by a simple measurement of the dissociation of the target molecule form the target's receptor. The later process is affected by a novel system and its configuration as described herein. Basic objectives are to provide a drug discovery and characterization system that is an improvement over the current state of the art, low cost, highly sensitive, accurate, fast and easy to use. This invention involves both a physical system and a methodology.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: June 5, 2012
    Assignee: University of Hawaii
    Inventor: James W. Holm-Kennedy
  • Publication number: 20120070867
    Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, a. b. in which c. A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, d. R1, R2 and R3 are independently of one another H, —O-C1-C6-alkyl , —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.
    Type: Application
    Filed: May 31, 2010
    Publication date: March 22, 2012
    Applicant: BASF SE
    Inventors: Steffen Maurer, Bemhard Hauer, Melanie Bonnekesse, Kurt Faber, Clemens Stückler
  • Publication number: 20120040424
    Abstract: The invention relates to a process for the enantioselective enzymatic reduction of secodione derivatives. The secodione derivative is reduced with an oxidoreductase/dehydrogenase in the presence of NADH or NADPH as a cofactor. The secodione derivative is used in the reaction batch at a concentration of ?10 g/l and the oxidized cofactor NAD or NADP formed by the oxidoreductase/dehydrogenase is regenerated continuously.
    Type: Application
    Filed: September 7, 2011
    Publication date: February 16, 2012
    Applicant: IEP GMBH
    Inventors: Antje GUPTA, Anke TSCHENTSCHER, Maria BOBKOVA
  • Patent number: 7910063
    Abstract: A device for detection of magnetic permeability ? or, alternatively, relative magnetic permeability ?r or, alternatively, relative magnetic susceptibility (?r?1) of a sample, wherein said device contains a sample chamber and at least two coils, one coil surrounding said sample chamber and one coil placed so as to be in thermal contact by being physically connected to the material which constitutes the sample chamber, but without surrounding the cavity of the sample chamber, said sample chamber having at least one opening for introduction of a sample or a sample container holding a sample, said device also provided with an electronic circuit which measures the difference in inductance between the two coils.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: March 22, 2011
    Assignee: Lifeassays AB
    Inventor: Dario Kriz
  • Publication number: 20110020887
    Abstract: The invention relates to a process for the enantioselective enzymatic reduction of secodione derivatives. The secodione derivative is reduced with an oxidoreductase/dehydrogenase in the presence of NADH or NADPH as a cofactor. The secodione derivative is used in the reaction batch at a concentration of ?10 g/l and the oxidized cofactor NAD or NADP formed by the oxidoreductase/dehydrogenase is regenerated continuously.
    Type: Application
    Filed: December 7, 2007
    Publication date: January 27, 2011
    Applicant: IEP GMBH
    Inventors: Antje Gupta, Anke Tschentscher, Maria Bobkova
  • Patent number: 7767437
    Abstract: The system includes a liquid transport structure configured to hold a sensor for detecting one or more components in a liquid. The liquid transport structure includes a reservoir configured to hold a liquid within the liquid transport structure and a channel configured to transport a liquid held in the reservoir to a sensor held by the liquid transport structure.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: August 3, 2010
    Assignee: GeneFluidics, Inc.
    Inventor: Vincent Jen-Jr Gau
  • Publication number: 20090061471
    Abstract: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.
    Type: Application
    Filed: August 4, 2007
    Publication date: March 5, 2009
    Inventors: Rudi Fasan, Frances H. Arnold
  • Patent number: 7258878
    Abstract: The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: August 21, 2007
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Sharon Linda Greene, Yanbin Huang, Lei Huang, Ilona F. Weart, Shu-Ping Yang, Sohail Malik, Robert B. Johnson
  • Patent number: 6995045
    Abstract: The thin film transistor has a non-transparent structure besides and insulated with the gate. Hence, the light transmitted from the substrate is blocked and the light current induced in the thin film transistor is negligible. The method uses a mask with a slit pattern to form a non-uniform photoresist. Hence, the mask could be used to pattern two conductor layers for forming source/drain/channel.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: February 7, 2006
    Assignee: Chunghwa Picture Tubes, Ltd.
    Inventors: Hung-Jen Chu, Nei-Jen Hsiao, Hui-Chung Shen, Meng-Chi Liou
  • Patent number: 6773944
    Abstract: A semiconductor device is provided which is constituted by semiconductor devices including a thin film transistor with a GOLD structure, the GOLD structure thin film transistor being such that: a semiconductor layer, a gate insulating film, and a gate electrode are formed in lamination from the side closer to a substrate; the gate electrode is constituted of a first-layer gate electrode and a second-layer gate electrode shorter in the size than the first-layer gate electrode; the first-layer gate electrode corresponding to the region exposed from the second-layer gate electrode is formed into a tapered shape so as to be thinner toward the end portion; a first impurity region is formed in the semiconductor layer corresponding to the region with the tapered shape; and a second impurity region having the same conductivity as the first impurity region is formed in the semiconductor layer corresponding to the outside of the first-layer gate electrode, which is characterized in that a dry etching process consisting
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: August 10, 2004
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventor: Satoru Okamoto
  • Publication number: 20030027295
    Abstract: An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: 1
    Type: Application
    Filed: May 17, 2002
    Publication date: February 6, 2003
    Applicant: Sumitomo Chemical Co., Ltd.
    Inventors: Takeshi Ishii, Satoshi Mitsuda
  • Patent number: 6472189
    Abstract: An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: wherein R1 is hydrogen or methyl, and R2 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C4 haloalkyl, a C5-C9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C5-C9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: October 29, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takeshi Ishii, Satoshi Mitsuda
  • Patent number: 6465224
    Abstract: Two gene clusters have been isolated from an Brevibacterium sp HCU that encode the enzymes expected to convert cyclohexanol to adipic acid. Individual open reading frames (ORF's) on each gene cluster are useful for the production of intermediates in the adipic acid biosynthetic pathway or of related molecules. All the ORF's have been sequenced. Identification of gene function has been made on the basis of sequence comparison and biochemical analysis.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: October 15, 2002
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Patricia C. Brzostowicz, Pierre E. Rouviere
  • Patent number: 6355420
    Abstract: Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: March 12, 2002
    Assignee: US Genomics
    Inventor: Eugene Y. Chan
  • Patent number: 5344994
    Abstract: Coniferyl aldehyde can be prepared from eugenol with the aid of fungi or their constituents.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: September 6, 1994
    Assignee: Haarmann & Reimer GmbH
    Inventors: Wolf-Rainer Abraham, Hans-Adolf Arfmann
  • Patent number: 5300437
    Abstract: Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: April 5, 1994
    Assignee: Celgene Corporation
    Inventors: David I. Stirling, George W. Matcham, Andrew L. Zeitlin
  • Patent number: 5093250
    Abstract: Claimed is a process for the production of optically active bicyclo[3.3.0]octanedione-carboxylic acid esters of Formula I ##STR1## wherein R.sub.1 and R.sub.2 jointly represent an oxygen atom, orR.sub.1 and R.sub.2 individually represent the residue OR.sub.4 where R.sub.4 means methyl- or ethyl-, andR.sub.3 is a straight or branched-chain alkyl group of 1-3 carbon atoms,comprising enantioselectively saponifying and decarboxylating with .alpha.-chymotrypsin an optically inactive, prochiral bicyclo[3.3.0]octanedionedicarboxylic acid diester of Formula II ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 have the meanings set forth above, and recovering a compound of Formula I.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: March 3, 1992
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Werner Skuballa
  • Patent number: 4957867
    Abstract: A process for preparing an optically active cyclopentenone of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group and n is an integer of 4 to 8, which comprises contacting a dl-cyclopentenone ester of the formula: ##STR2## wherein R and n are each as defined above and R' is a lower alkyl group optionally substituted with halogen on an enzyme having a capability of hydrolyzing selectively either one of the d- or l-form isomer in the dl-cyclopentenone ester (II) in an aqueous medium for asymmetric hydrolysis.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: September 18, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayoshi Minai, Yuji Ueda, Takayuki Higashii, Michitada Kondo, Seiichi Kai
  • Patent number: 4729953
    Abstract: A process for preparing an optically active 4-hydroxy-2-cyclopentenone of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a methyl group, R.sub.2 is an alkyl group, an alkenyl group or an alkynyl group and the asterisk (*) indicates an asymmetric configuration, which comprises subjecting an optically active 4-cyclopentenone-alcohol of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are each as defined above, the asterisk (*) indicates an asymmetric configuration and the substituents R.sub.1 and R.sub.2 take a cis-configuration to rearrangement while maintaining the original steric configuration.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: March 8, 1988
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayoshi Minai, Tadashi Katsura
  • Patent number: 4607013
    Abstract: A biochemical process for optical resolution of 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone, which comprises asymmetrically hydrolyzing organic carboxylic acid (saturated or unsaturated carboxylic acids having 1 to 18 carbon atoms) esters of (.+-.)-4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone by the action of an esterase originated from a microorganism or an animal pancreas to give optically active 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone and esters of its antipode with high optical purity is disclosed. This resolution process is simple in steps as compared with the conventionally known organic chemical methods of optical resolution, and is quite advantageous industrially because it does not require expensive optically active reagents.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: August 19, 1986
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Mitsuda, Hideo Hirohara
  • Patent number: 4511655
    Abstract: A 4-cyclopentenone of the formula: ##STR1## wherein R is a lower alkyl group, a lower alkenyl group or a lower alkynyl group and R' is a hydroxyl group or an aliphatic acyloxy group, provided that in case of the dl-form, R' is not a hydroxyl group and also that the substituent R at the 2-position and the methyl group at the 3-position take a cis-configuration in the dl-, d- or l-form.
    Type: Grant
    Filed: November 19, 1982
    Date of Patent: April 16, 1985
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayoshi Minai, Tadashi Katsura
  • Patent number: 4443541
    Abstract: A process for the microbiological conversion of steroids to (2+)-(7aS) 2,3,7,7-tetrahydro-7a-methyl-(1H)-indene-1,5(6H)-dione, hereinafter referred to as the indenedione.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: April 17, 1984
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Patent number: 4304860
    Abstract: Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: December 8, 1981
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha