Containing Carbonyl Group Patents (Class 435/147)
  • Patent number: 10301603
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Reg Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Patent number: 10150975
    Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: December 11, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Andreas W. Schirmer, Mathew A. Rude, Shane A. Brubaker
  • Patent number: 10118173
    Abstract: Method that includes providing a phase-separation device having a porous membrane with a filter surface. The filter surface has a non-planar contour that forms a receiving cavity. The method also includes providing a liquid mixture into the receiving cavity of the porous membrane. The liquid mixture includes a polar liquid and a non-polar liquid that are immiscible with respect to each other. The filter surface along the receiving cavity has a surface energy that impedes flow of the polar liquid through the filter surface and permit flow of the non-polar liquid into the porous membrane. The method also includes permitting the non-polar liquid to flow into the porous membrane. The polar liquid forms a droplet within the receiving cavity as the non-polar liquid flows into the porous membrane.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 6, 2018
    Assignee: ILLUMINA, INC.
    Inventors: Eric Hans Vermaas, Matthew Hage
  • Patent number: 10017797
    Abstract: The present invention discloses a novel method for biological reduction of the carboxylic acids to their corresponding aldehydes and/or alcohols with high productivity and high yield by using fungus in the category of basidiomycetes. This reduction is specific and selective for its functional group (—COOH), without affecting other functional group such as—R groups (—OH, —NH2, -alkyl, -alkyoxy) and their position, number on aromatic ring. The method of the invention relates to reduction of aryl acids to aldehyde and/or alcohols by employing a white rot fungus—Pycnoporus cinnabarinus, an organism of basidiomycete species, grown in vessel/column. The biotransformation was performed in vessel/column/fermentor with pH control, dissolved oxygen, membrane system, product extractor is attached.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: July 10, 2018
    Assignee: PRIVI BIOTECHNOLOGIES PRIVATE LIMITED
    Inventors: Mahendra M Yeole, Arvind M. Lali
  • Patent number: 9777297
    Abstract: Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than post-fermentation recovery of n-butyraldehyde alone.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: October 3, 2017
    Assignee: EASEL BIOTECHNOLOGIES, LLC
    Inventors: Kwang Myung Cho, Wendy Higashide, Chrissie Lee, Shahrooz Rabizadeh
  • Patent number: 9758759
    Abstract: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of ferulic acid substrate, the vanillin production by this method can reach more than 10 g/L. The molar conversion rate of ferulic acid is more than 50% and the purity of vanillin is from 80% to 95%. The advantage of this invention includes: repeated use of biocatalyst cells, mild biotransformation condition, low environmental pollution, short production cycle, high product purity and simple purification procedure. It has a great potential for industrial applications.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: September 12, 2017
    Assignee: BGN TECH LLC
    Inventors: Pu Zheng, Hui Li, Xinglin Wang, Jianhai Zhou, Shibiao Chu
  • Patent number: 9573876
    Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to retro-aldol reaction products and methods of making and using same. More particularly, but without limitation, the methods disclosed herein for producing the retro-aldol reaction products are performed in a non-aqueous/solvent-free based process. The reaction products obtained from the process include, for example, dihydroxyacetone, glyceraldehyde, glycolaldehyde, and combinations thereof. In one particular embodiment, the process of making such retro-aldol reaction products includes, without limitation, the step of mechanocatalytically reacting a heterogeneous catalyst with one or more sugar reactants.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: February 21, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Richard Blair
  • Patent number: 9556458
    Abstract: The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces ?-ketoacyl-CoAs through a re-engineered ?-oxidation pathway and overexpresses FadM.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: January 31, 2017
    Assignee: The Regents of the University of California
    Inventors: Harry R. Beller, Ee-Been Goh
  • Patent number: 9273291
    Abstract: The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: March 1, 2016
    Assignee: Universitat Graz
    Inventors: Aashrita Rajagopalan, Wolfgang Kroutil, Markus Schober
  • Patent number: 9206443
    Abstract: An improved process for alcohol production includes microbial fermentation using a genetically modified microorganism to produce substantial quantities of aldehydes that are stripped from the fermentation medium and condensed. So produced aldehydes are converted in an ex vivo process to corresponding alcohols.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: December 8, 2015
    Assignee: Easel Biotechnologies, LLC
    Inventors: Wendy M. Higashide, Kwang Myung Cho, Shahrooz Rabizadeh
  • Patent number: 9121042
    Abstract: Recombinant butyraldehyde dehydrogenases (Blds) with improved production of 1,4-BDO, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant Blds, and methods of producing 1,4-BDO by using the recombinant microorganisms.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: September 1, 2015
    Assignees: SAMSUNG ELECTRONICS CO., LTD., AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jin-hwan Park, Pyung-cheon Lee, Jae-chan Park, Young-min Lee, Woo-yong Lee
  • Publication number: 20150125912
    Abstract: The invention provides a process for the preparation of hydrocarbons substituted with at least one group containing at least one oxygen atom, comprising the process steps A) reaction of a carbon source comprising at least one selected from CO2 and CO to give acetate and/or ethanol with a first microorganism, B) separating off of the acetate from the first microorganism, C) reaction of the acetate to give a hydrocarbon substituted with at least one group containing at least one oxygen atom with a second microorganism and optionally D) purification of the hydrocarbon substituted with at least one group containing at least one oxygen atom.
    Type: Application
    Filed: May 8, 2013
    Publication date: May 7, 2015
    Applicant: Evonik Industries AG
    Inventors: Thomas Haas, Eva Maria Wittmann
  • Patent number: 9023627
    Abstract: Systems, compounds and methods for the conversion of C1 carbon compounds to higher carbon compounds useful for the generation of commodity compounds.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: May 5, 2015
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Justin Siegel, David Baker, Amanda Lee Smith, Mary E. Lidstrom, Catherine Louw
  • Publication number: 20150111268
    Abstract: Recombinant butyraldehyde dehydrogenases (Blds) with improved production of 1,4-BDO, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant Blds, and methods of producing 1,4-BDO by using the recombinant microorganisms.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 23, 2015
    Inventors: Jinhwan Park, Pyungcheon Lee, Jaechan Park, Youngmin Lee, Wooyong Lee, Jinwoo Park, Kwangmyung Cho, Heejin Hwang
  • Patent number: 8999686
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: April 7, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Publication number: 20150064756
    Abstract: The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.
    Type: Application
    Filed: August 9, 2012
    Publication date: March 5, 2015
    Applicant: UNIVERSITAT GRAZ
    Inventors: Aashrita Rajagopalan, Wolfgang Kroutil, Markus Schober
  • Patent number: 8956835
    Abstract: Methods are provided for producing biodegradable polyhydroxyalkanoates (PHAs) with desired geometry, molecular mass, mechanical and/or physical-chemical properties from glycerol, an inexpensive carbon source and byproduct of the biodiesel industry. Microorganisms capable of converting carbon to PHA can be used to convert biodiesel-glycerol to poly-3-hydroxybutyrate (PHB) or other monomer or copolymer PHAs via fermentation. The microorganisms are cultured in a medium comprising glycerol as a primary carbon source and one or more low molecular mass organic acids as a secondary carbon source. Biomass can be harvested from the culture medium and crude PHA extracted and purified, thereby recovering purified PHA with the desired property. After PHA isolation, a nucleating agent can be added to improve certain physical-chemical properties of the PHA, e.g., crystallization temperature, to enhance performance of the PHA during injection molding.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: February 17, 2015
    Assignee: Suny Research Foundation
    Inventors: James P. Nakas, Chengjun Zhu, Joseph A. Perrotta, Christopher T. Nomura
  • Publication number: 20150044744
    Abstract: The invention relates to a method for oxidizing an alkane, comprising contacting the alkane with a type alkB oxidoreductase and using a type alkB oxidoreductase to prepare a mixture of oxidation products of an alkane, wherein the ratio of carboxylic acid to alcohol in the oxidation products is preferably greater than 1:1.
    Type: Application
    Filed: November 22, 2012
    Publication date: February 12, 2015
    Applicant: EVONIK INDUSTRIES AG
    Inventors: Jan Christoph Pfeffer, Thomas Haas, Oliver Thum, Frank Erhardt, Eva Maria Wittmann, Christian Gehring, Sabine Hafkemeyer, Thomas Hueller
  • Patent number: 8951771
    Abstract: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: February 10, 2015
    Assignee: Firmenich SA
    Inventors: Fredi Bruhlmann, Laurent Fourage, Denis Wahler
  • Publication number: 20150031095
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 29, 2015
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • Publication number: 20150004660
    Abstract: Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 1, 2015
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes
  • Publication number: 20140371417
    Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
    Type: Application
    Filed: April 25, 2014
    Publication date: December 18, 2014
    Applicant: Genomatica, Inc.
    Inventors: Priti PHARKYA, Anthony P. BURGARD, Stephen J. VAN DIEN, Robin E. OSTERHOUT, Mark J. BURK, John D. TRAWICK, Michael P. KUCKINSKAS, Brian STEER
  • Publication number: 20140356918
    Abstract: The subject of the present invention is a process for synthesizing bifunctional hydrocarbon-based compounds from biomass, comprising a step of fermentation of the biomass and a step of oxidation of the intermediate compounds resulting from the fermentation step.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 4, 2014
    Applicant: Arkema France
    Inventor: Jean-Luc Dubois
  • Patent number: 8883475
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: November 11, 2014
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, Vesna Mitchell, Xiyun Zhang, Gjalt Huisman
  • Publication number: 20140329916
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
    Type: Application
    Filed: December 16, 2013
    Publication date: November 6, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Publication number: 20140322774
    Abstract: Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than post-fermentation recovery of n-butyraldehyde alone.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 30, 2014
    Inventors: Kwang Myung Cho, Wendy Higashide, Chrissie Lee, Shahrooz Rabizadeh
  • Publication number: 20140308718
    Abstract: The invention refers to a method of biotransforming a carbohydrate of a raw material into a chemical, by cultivating Lactobacillus diolivorans in the presence of the raw material to produce a chemical substance, and isolating the chemical substance in the purified form, and the use of L. diolivorans in one of a series of biotransformation methods, wherein carbohydrates from at least two different carbohydrate sources of low purity are transformed into chemicals.
    Type: Application
    Filed: November 5, 2012
    Publication date: October 16, 2014
    Inventors: Michael Sauer, Hans Marx, Stefan Pfluegl, Diethard Mattanovich
  • Publication number: 20140302575
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol. Also provided herein are methods for using such an organism to produce 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol.
    Type: Application
    Filed: November 4, 2013
    Publication date: October 9, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Publication number: 20140288254
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
    Type: Application
    Filed: November 4, 2013
    Publication date: September 25, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Publication number: 20140287458
    Abstract: The present invention provides a method of producing a photosynthetic product, the method comprising maintaining a photosynthetic plant or algal cell suspension culture, in the presence of water, light and a carbonic acid-enriched growth medium. The carbonic acid may, for example be provided by feeding the photosynthetic plant cell suspension culture with a carbonic acid solution, a solid or liquid precursor thereof, or a gaseous mixture of carbon dioxide and one or more other gases. The invention also provides a method for producing a photosynthetic product, the method comprising maintaining a photosynthetic plant or algal cell suspension culture, in the presence of water, light and a carbon source selected from carbon dioxide and carbonic acid, wherein the culture is maintained at a pH of less than 7.0, preferably 4.5 to 5.5.
    Type: Application
    Filed: May 18, 2012
    Publication date: September 25, 2014
    Applicant: NATURALLY SCIENTIFIC TECHNOLOGIES LIMITED
    Inventor: Peter Andrew Whitton
  • Publication number: 20140245496
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Application
    Filed: August 7, 2012
    Publication date: August 28, 2014
    Applicants: EVOLVA SA, INTERNATIONAL FLAVORS & FRAGRANCES INC.
    Inventors: Joergen Hansen, Esben Halkjaer Hansen, Honey Polur, Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton
  • Publication number: 20140235815
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
    Type: Application
    Filed: October 21, 2013
    Publication date: August 21, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Publication number: 20140234918
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: August 21, 2014
    Applicant: Novozymes A/S
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum
  • Publication number: 20140193864
    Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: INVISTA North America S.á r.l.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie, Changlin Chen, Paul S. Pearlman
  • Publication number: 20140178953
    Abstract: The present invention relates to a host cell having an elevated expression or activity of an enzyme as compared with the parent cell from which it has been derived, said enzyme having lactoyl-CoA reductase activity. Furthermore, provided is a method of producing lactaldehyde and/or 1,2-propanediol, said method comprising culturing said host cell and/or utilizing said enzyme to produce said compound.
    Type: Application
    Filed: June 15, 2012
    Publication date: June 26, 2014
    Applicant: B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG
    Inventors: Daniel Koch, Guido Meurer, Jürgen Eck
  • Publication number: 20140170720
    Abstract: The present invention relates to a method for producing retinoid from a microorganism, and more specifically, to a method for effectively obtaining retinoid, which lacks stability, from a microorganism by cultivating the microorganism capable of producing retinoid in a medium containing a lipophilic substance, and separating retinoid from the lipophilic substance.
    Type: Application
    Filed: July 30, 2012
    Publication date: June 19, 2014
    Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
    Inventors: Seon Won Kim, Hui Jeong Jang, Sang Hwal Yoon, Bo Kyung Ha, Hee Kyung Ryu
  • Publication number: 20140154746
    Abstract: The present invention relates to a method of enzymatic hydrolysis of a lignocellulosic material, comprising the steps of: a) pretreating the lignocellulosic material to obtain a slurry having a pH of less than 6; b) adding NaOH, Ca(OH)2 and/or CaO to the slurry to increase its pH to at least 8, said addition being carried out at a slurry temperature of at least 60° C.; c) reducing the pH of the slurry to below 7; and optionally cooling the slurry from step b) to a temperature below 60° C.
    Type: Application
    Filed: June 11, 2012
    Publication date: June 5, 2014
    Applicant: Sekab E-Technology AB
    Inventors: Leif Jönsson, Björn Alriksson, Venkata Prabhakar Soudhama
  • Patent number: 8741593
    Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II?): R?7R?8(HX)C1-C2(YH)R?9R?10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II?): R?7 to R?10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II?). The released product can be a volatile molecule or an active substance or else a specific product.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: June 3, 2014
    Assignee: Proteus
    Inventors: Jean-Louis Reymond, Denis Wahler, Frabrizzio Badalassi, Hong-Khanh Nguyen
  • Publication number: 20140127765
    Abstract: The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.
    Type: Application
    Filed: October 14, 2013
    Publication date: May 8, 2014
    Applicant: GENOMATICA, INC.
    Inventors: Robin E. Osterhout, Anthony P. Burgard
  • Patent number: 8709771
    Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 29, 2014
    Assignee: Xyleco, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman
  • Patent number: 8709767
    Abstract: A process for the enzymatic reduction of an enoate (1) wherein the C?C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R?H or optionally substituted C1-C6-alkyl radical, R1, R2 and R3 are independently of one another H, —O—C1-C6-alkyl, —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1 is linked to R3 so as to become part of a 4-8-membered cycle, or R1 is linked to R so as to become part of a 4-8-membered cycle, with the proviso that R1, R2 and R3 may not be identical.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: April 29, 2014
    Assignee: BASF SE
    Inventors: Stephan Maurer, Bernhard Hauer, Melanie Bonnekessel, Kurt Faber, Clemens Stückler
  • Publication number: 20140113966
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: October 22, 2012
    Publication date: April 24, 2014
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: ROBERT DICOSIMO, MARK SCOTT PAYNE, JOHN EDWARD GAVAGAN
  • Publication number: 20140106422
    Abstract: This invention relates to methods of obtaining volatile hydrocarbons produced by photosynthetic microorganisms using a two-phase gaseous/aqueous bioreactor.
    Type: Application
    Filed: April 20, 2012
    Publication date: April 17, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Anastasios Melis, Fiona Bentley, Hsu-Ching Chen Wintz
  • Publication number: 20140087428
    Abstract: The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.
    Type: Application
    Filed: June 18, 2012
    Publication date: March 27, 2014
    Inventors: Stefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
  • Publication number: 20140086879
    Abstract: Disclosed herein is an isolated Muscodor albus strain producing volatile organic compounds such as aristolene, 3-octanone and/or acetic acid ester, as well as cultures of said strain and compositions, metabolites and volatiles derived from said strain or culture as well as methods of obtaining said compositions, metabolites and volatiles and their methods of use for controlling pests. Also disclosed are artificial compositions having the same components and uses as the volatiles derived from the strain. A method for capturing and sampling the volatiles is also disclosed.
    Type: Application
    Filed: September 23, 2013
    Publication date: March 27, 2014
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Gary Strobel, Vu Phong Bui, Hai Su, Phyllis Himmel, Pamela Marrone, Lijuan Xing, Sarah Lewis
  • Publication number: 20140058056
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
    Type: Application
    Filed: August 26, 2013
    Publication date: February 27, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Publication number: 20140057992
    Abstract: Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterm in the bacterial cell during preservation and storage, in particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterm, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
    Type: Application
    Filed: November 4, 2013
    Publication date: February 27, 2014
    Inventor: Stefan Roos
  • Patent number: 8658404
    Abstract: Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: February 25, 2014
    Assignee: LS9, Inc.
    Inventors: Andreas W. Schirmer, Mathew A. Rude, Shane A. Brubaker
  • Publication number: 20140045232
    Abstract: Recombinant butyraldehyde dehydrogenases (Blds) with improved production of 1,4-BDO, as well as recombinant microorganisms comprising polynucleotides encoding the recombinant Blds, and methods of producing 1,4-BDO by using the recombinant microorganisms.
    Type: Application
    Filed: July 30, 2013
    Publication date: February 13, 2014
    Inventors: Jin-hwan PARK, Pyung-cheon LEE, Jae-chan PARK, Young-min LEE, Woo-yong LEE
  • Publication number: 20140024090
    Abstract: Method for converting a carbon source such as a plant-derived material into a hydrocarbon or hydrocarbon precursor, via a microorganism-catalysed aerobic reaction. The microorganism is cultivated in the presence of the carbon source and of oxygen, in a reaction vessel having a capacity of about 2000 litres or greater which comprises an aeration system for supplying oxygen to the microorganism. Also provided is an apparatus for use in the method, comprising a reaction vessel of capacity 2000 litres or greater, and an aeration system.
    Type: Application
    Filed: December 14, 2012
    Publication date: January 23, 2014
    Applicant: SHELL OIL COMPANY
    Inventors: Steven Daniel DOIG, Steven Richard BROWN, George Robert LEE, David Alexander PARKER