Carrier Is Synthetic Polymer Patents (Class 435/180)
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Publication number: 20110117596Abstract: A composite sorbent material is disclosed which comprises A) a housing of a dense, insoluble material having openings therein and B) a porous polymer gel housed within said housing, said housing being provided with openings therein for fluid communication between said porous monolithic polymer gel and the surroundings, and said porous monolithic polymer gel occupying the inner space of said housing and being kept on place within said housing by mechanical means. Processes for the preparation of composite sorbent materials by cryoprecipitation are also disclosed as well as the use of the composite sorbent material according to the invention e.g. for the removal of pollutants from gases or liquids, for the enrichment or separation of molecules and for cell culture.Type: ApplicationFiled: March 20, 2007Publication date: May 19, 2011Inventors: Bo Mattiasson, Fatima Plieva
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Patent number: 7943353Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.Type: GrantFiled: July 23, 2009Date of Patent: May 17, 2011Assignees: Agency for Science, Technology and Research, The National University of SingaporeInventors: Hanry Yu, Kam W Leong, Ser-Mien Chia, Andrew C. A. Wan
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Publication number: 20110111034Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.Type: ApplicationFiled: January 18, 2011Publication date: May 12, 2011Inventors: Dong-an Wang, Anthony Ratcliffe, Jennifer H. Elisseeff
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Publication number: 20110091955Abstract: Systems and methods for lowering levels of carbon dioxide and other atmospheric pollutants are provided. Economically viable systems and methods capable of removing vast quantities of carbon dioxide and other atmospheric pollutants from gaseous waste streams and sequestering them in storage stable forms are also discussed.Type: ApplicationFiled: October 19, 2010Publication date: April 21, 2011Inventors: BRENT R. CONSTANTZ, James Bresson, Divyam Chandra
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Publication number: 20110093965Abstract: The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.Type: ApplicationFiled: September 21, 2007Publication date: April 21, 2011Applicant: Verenium CorporationInventors: Eileen O'Donoghue, Nelson R. Barton
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Publication number: 20110076738Abstract: Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material that is useful for facilitating removal of bioorganic stains.Type: ApplicationFiled: September 27, 2010Publication date: March 31, 2011Applicants: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC, REGENTS OF THE UNIVERSITY OF MINNESOTA, TOYOTA MOTOR CORPORATIONInventors: PING WANG, SONGTAO WU, HONGFEI JIA, MASAHIKO ISHII, XIAODONG TONG, MINJUAN ZHANG
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Patent number: 7915028Abstract: A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.Type: GrantFiled: November 19, 2004Date of Patent: March 29, 2011Assignee: Teijin LimitedInventors: Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masatsugu Shimomura, Masaru Tanaka
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Patent number: 7906305Abstract: Provided is a process for preparing an immobilized enzyme, which comprises the steps of immobilizing an enzyme used for decomposing oil & fat on a carrier, by adsorption, without drying, bringing the immobilized enzyme into contact with a fatty acid triglyceride or fatty acid partial glyceride, or mixtures thereof, and adjusting the moisture content of the enzyme to 5% to 50% by weight based on the weight of the carrier, wherein the enzyme is used for esterification.Type: GrantFiled: January 29, 2007Date of Patent: March 15, 2011Assignee: Kao CorporationInventors: Manabu Sato, Masami Shimizu, Minoru Kase, Takaaki Watanabe, Jun Kohori
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Patent number: 7906135Abstract: Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.Type: GrantFiled: May 15, 2007Date of Patent: March 15, 2011Assignee: Metabolix, Inc.Inventors: Simon F. Williams, David P. Martin, Tillman Gerngross, Daniel M. Horowitz
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Publication number: 20110059059Abstract: Compositions and methods for treating ischemic tissue are provided herein.Type: ApplicationFiled: October 28, 2010Publication date: March 10, 2011Applicant: Theregen, Inc.Inventors: Robert S. Kellar, Gail K. Naughton, Stuart K. Williams
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Publication number: 20110053243Abstract: A conjugate of a randomly and asymmetrically branched dendritic polymer and a member of a binding pair.Type: ApplicationFiled: July 11, 2010Publication date: March 3, 2011Applicant: ANP TECHNOLOGIES, INC.Inventors: Ray Yin, Dujie Qin, Jing Pan
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Publication number: 20110053229Abstract: Provided is a method of producing an immobilized lipolytic enzyme which has almost the same ability as that of an unused immobilized enzyme by effectively utilizing an immobilization carrier in a used immobilized enzyme which has been used in an esterification reaction. The method of producing an immobilized lipolytic enzyme includes: mixing an immobilized lipolytic enzyme that has been used in an esterification reaction with a solvent to wash the immobilized lipolytic enzyme so that the residual oil content in the immobilized lipolytic enzyme is reduced to 50 parts by mass or less based on 100 parts by mass of an immobilization carrier; bringing the immobilized lipolytic enzyme into contact with an alkali solution; collecting the immobilization carrier; and adsorbing a lipolytic enzyme on the immobilization carrier.Type: ApplicationFiled: April 20, 2009Publication date: March 3, 2011Applicant: Kao CorporationInventors: Shinpei Fukuhara, Minoru Kase, Toshiteru Komatsu
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Publication number: 20110053783Abstract: The invention provides a surface, wherein said surface comprises (i) a polymer substrate and (ii) sugar groups and peptide groups coupled to said substrate suitable for culturing hepatocytes.Type: ApplicationFiled: May 24, 2007Publication date: March 3, 2011Applicant: Agency of Science, Technology and ResearchInventors: Yanan Du, Rongbin Han, Hanry Yu
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Patent number: 7897042Abstract: Entrapping immobilization pellets for purifying breeding water in an aquarium to breed aquatic animals, wherein the entrapping immobilization pellets have a phosphorus content of 0.05 mass % or less.Type: GrantFiled: March 23, 2009Date of Patent: March 1, 2011Assignee: Hitachi Plant Technologies, Ltd.Inventors: Shinichi Yoshikawa, Naoki Abe, Kazuichi Isaka
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Publication number: 20110042325Abstract: Efficient, targeted delivery of polymer entrapped nanoparticles, nutrients and microorganisms is provided by amphiphilic polysiloxane graft copolymers (APGC) based metal nanoparticle delivery vehicles configured to increase colloidal stability, reduce oxidation by non-target compounds, and have affinity towards water/contaminant interfaces.Type: ApplicationFiled: March 6, 2009Publication date: February 24, 2011Applicant: NDSU RESEARCH FOUNDATIONInventors: Achintya N. Bezbaruah, Bret J. Chisholm, Sita Krajangpan
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Patent number: 7892800Abstract: The present invention relates to a composite material made of non-metallic inorganic grains and plastics particles. The composite material is particularly suitable as a carrier material for bacteria for use in sewage treatment plants. It is characterized by a large surface suitable for the colonization of bacteria and also by a density which allows the composite material to be suspended in the medium present in the sewage treatment plant. A further advantage of the composite material according to the invention is the property that due to the surface structure of the composite material adhering sludge and saturated bacteria can fall off its surface, and this thus allows regeneration of the material.Type: GrantFiled: December 22, 2004Date of Patent: February 22, 2011Assignee: Pfleiderer Water Systems GmbHInventor: Antonio Giangrasso
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Publication number: 20110038828Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: ApplicationFiled: October 27, 2010Publication date: February 17, 2011Applicant: REGENTIS BIOMATERIALS LTD.Inventors: DROR SELIKTAR, LIORA ALMANY
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Patent number: 7888086Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.Type: GrantFiled: July 24, 2008Date of Patent: February 15, 2011Assignee: Promega CorporationInventors: Aldis Darzins, Lance Encell, Tonny Johnson, Dieter Klaubert, Georgyi V. Los, Mark McDougall, Keith V. Wood, Monika G. Wood, Chad Zimprich
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Patent number: 7883859Abstract: The present invention relates to a bioassay element and its producing method. The bioassay element includes a carrier, a testing material, and a coating film, in which the testing material is dispersed in the coating film which covers on the surface of the carrier and comprises a casein and calcium ions. The bioassay element is produced by applying a bioassay solution which includes a testing material, a casein and calcium ions to the carrier, and then drying the bioassay solution.Type: GrantFiled: December 13, 2006Date of Patent: February 8, 2011Assignee: Industrial Technology Research InstituteInventor: Reiko OHaRa
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Publication number: 20110027346Abstract: This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.Type: ApplicationFiled: May 29, 2007Publication date: February 3, 2011Applicant: VERENIUM CORPORATIONInventors: David Weiner, Alexander Varvak, Toby Richardson, Mircea Podar, Ellen Burke, Shaun Healey
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Patent number: 7868145Abstract: A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis.Type: GrantFiled: July 11, 2007Date of Patent: January 11, 2011Assignee: Industrial Technology Research InstituteInventors: Kun Chan Wu, Hui-Ju Cho, Pei-Shin Jiang, Hsiang Yuan Huang, Wen-Hsun Kuo, Chi-Min Chau, Chih Hsien Su, Kun Feng Lee
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Patent number: 7857849Abstract: A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.Type: GrantFiled: October 4, 2005Date of Patent: December 28, 2010Assignees: The Board of Trustees of the Leland Stanford Junior Iniversity, Santa Clara UniversityInventors: David Myung, Jaan Noolandi, Alan J. Smith, Curtis W. Frank, Christopher Ta, Yin Hu, Won-Gun Koh, Michael R. Carrasco
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Publication number: 20100316614Abstract: The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration.Type: ApplicationFiled: June 16, 2010Publication date: December 16, 2010Applicant: NORTHWESTERN UNIVERSITYInventors: Arun Sharma, Partha Hota, Natalie Fuller, Derek Matoka, Earl Cheng
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Patent number: 7851189Abstract: A tissue engineering composition adapted for application to an interior surface of a body lumen of a patient. The composition comprises (a) a carrier medium that is adapted to flow and to stably adhere the composition to the body lumen and (b) microcapsules, which are dispersed within the carrier medium and which contain one or more living cells encapsulated within a coating that includes a biodegradable polymer. The composition promotes growth of the cells on the lumen surface subsequent to application of the composition to the lumen.Type: GrantFiled: March 7, 2005Date of Patent: December 14, 2010Assignee: Boston Scientific Scimed, Inc.Inventors: Toby M. Freyman, Joseph A. Levendusky
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Publication number: 20100305217Abstract: The invention relates to a micro-porous membrane comprising a porous membrane carrier made of a first polymeric material (A) and comprising a second polymeric material (B) intimately divided throughout the porous membrane carrier, wherein the porous membrane carrier comprises a plurality of interconnected polymeric fibers, fibrils, filaments and/or lamellae having a thickness of less than 1 ?m, the porous membrane carrier has an interconnected open porous structure formed by the plurality of interconnected polymeric fibers, fibrils, filaments and/or lamellae and a porosity of at least 50%; and the polymeric material (B) comprises a thermoplastic polycondensation polymer and is present in an amount of at most 30 wt. %, relative to the total weight of (A) and (B).Type: ApplicationFiled: November 14, 2008Publication date: December 2, 2010Inventors: Jun Qiu, Rudy Rulkens, Johannes Leornardus Maria OP Den Kamp, Jens Christoph Thies
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Publication number: 20100303893Abstract: Specific modifying agent is coupled to an anti-tumor protein on a certain site. It conquers the disadvantages which include high antigenicity, short circulating half-life, nonuniform modified sites, inhomogeneous component, reduced activity and uncontrollable quality of the products prepared by non-specific modifying method. The anti-tumor protein coupled with specific modifying agent can be used for the treatment of tumor and for manufacturing an anti-tumor medicament.Type: ApplicationFiled: January 19, 2007Publication date: December 2, 2010Inventors: Yongzhang Luo, Hao Zhou, Qingxin Lei, Guodong Chang
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Publication number: 20100299782Abstract: The invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling CO2 sensor genes. The invention provides compositions and methods for enhancing or optimizing biomass accumulation in a plant. The invention provides compositions and methods for for opening or closing a stomatal pore on a guard cell in the epidermis of a plant. The invention provides compositions and methods for increasing or decreasing oxygenation efficiency and/or carbon fixation in a guard cell in the epidermis of a plant by manipulating expression of a ribulose-1,5-bisphosphate carboxylase/oxygenase. The invention provides promoters for regulating expression of a nucleic acid in a plant guard cell.Type: ApplicationFiled: April 25, 2008Publication date: November 25, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Julian Schroeder, Maria Israelsson-Nordstrom, Josef M. Kuhn, Yingzhen Yang, Honghong Hu, Aurelien Boisson-Dernier
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Publication number: 20100298925Abstract: Spinulose metal surfaces are produced by a modified nanoplasma cyclic deposition process. The unique spinulose surfaces are highly adherent toward polymer and bioactive molecules and cells, including osteoblast, fibroblast and endothelial cells. The nanostructured spinulose surfaces can be coated with a wide range of polymers to form polymer surface coatings that are particularly useful on implants, catheters, guidewires, stents and other medical devices intended for in vivo applications.Type: ApplicationFiled: June 16, 2010Publication date: November 25, 2010Applicant: CHAMELEON SCIENTIFIC CORPORATIONInventors: CHRISTINA K. THOMAS, DANIEL M. STOREY
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Publication number: 20100291179Abstract: The present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure. The active ingredients are in this case incorporated into the composite biomaterial via the matrix structure, and the composite biomaterial is obtainable by introducing the matrix structure into the support structure. The active ingredients may in this case be incorporated for example adhesively, via specific binder molecules or via enzyme-labile linker molecules via the matrix structure into the composite biomaterial.Type: ApplicationFiled: April 16, 2010Publication date: November 18, 2010Inventors: Dieter Stoll, Reinout Stoop, Juliana Vaz Nürnberger, Christoph Gaissmaier, Michael Ahlers, Claudia Bohnsack
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Patent number: 7833778Abstract: The present invention describes a method for producing butanol by fermentation of carbohydrates using mixed populations of acidogenic-phase cells and solventogenic-phase cells of Clostridium in a solitary vessel. The present system as described does not require intermittent adjustment of pH or venting of headspace gases. The method provides a process for removal of the butanol product which does not irreversibly harm the cells and conditions are described where such cells may resume butanol synthesis in the same solitary vessel. The invention also describes compositions and biologically pure cultures which comprise the Clostridium cells as disclosed. Also, a biologically pure Clostridium beijerinkii strain NRRL No. B-50244 is disclosed.Type: GrantFiled: February 26, 2009Date of Patent: November 16, 2010Inventor: Eugene T. Butler, III
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Publication number: 20100279377Abstract: Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.Type: ApplicationFiled: May 20, 2010Publication date: November 4, 2010Applicant: MEDTRONIC MINIMED, INC.Inventors: Rajiv Shah, Gopikrishnan Soundararajan, Rebecca K. Gottlieb, Udo Hoss, Eric A. Grovender, Shaun M. Pendo
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Publication number: 20100279375Abstract: A method for producing an immobilized enzyme which includes the steps of immobilizing an enzyme used for hydrolyzing fats and oils on a immobilization carrier by adsorption, bringing the immobilized enzyme into contact with an organic solvent in which fat-soluble fatty acids or the derivatives thereof have been dissolved, and adjusting the moisture content of the immobilized enzyme from 1 to 20% by weight based on the weight of the carrier.Type: ApplicationFiled: July 20, 2010Publication date: November 4, 2010Applicant: KAO CORPORATIONInventors: Manabu SATO, Kazuhiro ONOZUKA, Takaaki WATANABE, Hiroyuki KONISHI
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Publication number: 20100279376Abstract: Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material.Type: ApplicationFiled: May 1, 2009Publication date: November 4, 2010Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota, Toyota Motor CorporationInventors: Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Xiaodong Tong, Minjuan Zhang
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Publication number: 20100273154Abstract: The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.Type: ApplicationFiled: January 18, 2008Publication date: October 28, 2010Applicant: SUNTORY HOLDINGS LIMITEDInventors: Misa Ochiai, Harukazu Fukami, Masahiro Nakao, Akio Noguchi
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Publication number: 20100267108Abstract: An emulsion-derived particle includes a lattice of polymeric strands cross-linked by means of a cross-linking agent, and interstitial openings adjacent and around the strands. Functional groups are provided on the lattice and proteins and/or modified proteins can react with these, thereby to be bonded to the lattice and hence immobilized.Type: ApplicationFiled: October 29, 2008Publication date: October 21, 2010Applicant: CSIRInventors: Justin Jordaan, Clinton Simpson, Dean Brady, Neil Stockenstrom Gardiner, Isak Bartholomeus Gerber
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Patent number: 7807428Abstract: A method for producing an immobilized enzyme which includes the steps of immobilizing an enzyme used for hydrolyzing fats and oils on a immobilization carrier by adsorption, bringing the immobilized enzyme into contact with an organic solvent in which fat-soluble fatty acids or the derivatives thereof have been dissolved, and adjusting the moisture content of the immobilized enzyme from 1 to 20% by weight based on the weight of the carrier.Type: GrantFiled: November 10, 2005Date of Patent: October 5, 2010Assignee: Kao CorporationInventors: Manabu Sato, Kazuhiro Onozuka, Takaaki Watanabe, Hiroyuki Konishi
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Publication number: 20100248229Abstract: The present invention relates to the field of stem cells particularly development of a novel human embryonic model using human embryoid bodies obtained from the human embryonic stem cell. The novel human embryonic model disclosed thus can provide a screening assay for determining the toxic activity of the compound and/or drug.Type: ApplicationFiled: April 11, 2008Publication date: September 30, 2010Applicant: Stempeutics Research Private LimitedInventors: Kaushik Dilip Deb, Satish Mahadeo Totey
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Publication number: 20100248324Abstract: A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.Type: ApplicationFiled: March 24, 2009Publication date: September 30, 2010Inventors: Ping Xu, Jack J. Hegenbarth, Xin Kang Chen
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Publication number: 20100248325Abstract: Enzyme preparations obtainable by providing an enzyme immobilizate with a silicone coating, the coating being obtained by hydrosilylating a self-crosslinking polysiloxane, a process for production thereof and the use thereof are provided.Type: ApplicationFiled: March 31, 2010Publication date: September 30, 2010Applicant: EVONIK GOLDSCHMIDT GMBHInventors: Marrit Eckstein, Michael Ferenz, Oliver Thum
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Patent number: 7803393Abstract: An implant for use in biological/biomedical applications may be prepared by subjecting a substrate to a gas-plasma treatment. The substrate may be a biocompatible material, including metals, ceramics, and polymers. More specifically, the substrate may be a bioresorbable polymer. The gas-plasma treatment may include subjecting the substrate to a plasma formed by a reactive gas. The gas-plasma treatment may be performed for a chosen duration at a radio frequency within a temperature range, a pressure range, and a supplied energy range. The substrate may be exposed to living cells, such that some of the living cells become coupled to the substrate. Gas-plasma treatment parameters may be chosen such that the living cells coupled to the treated substrate produce more of a cellular product than living cells coupled to an untreated substrate.Type: GrantFiled: March 6, 2003Date of Patent: September 28, 2010Assignee: Board of Regents, The University of Texas SystemInventors: C. Mauli Agrawal, Steven R. Bailey, Jodie L. Polan
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Patent number: 7799548Abstract: A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer containing a biomolecule with a tag. A separate bioreactor is also disclosed incorporating the wafer described above.Type: GrantFiled: April 5, 2007Date of Patent: September 21, 2010Assignee: Uchicago Argonne, LLCInventors: Michelle B. Arora, Jamie A. Hestekin, YuPo J. Lin, Edward J. St. Martin, Seth W. Snyder
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Publication number: 20100234948Abstract: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provide a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cells, and for an article for medical implantation.Type: ApplicationFiled: March 11, 2010Publication date: September 16, 2010Applicant: EXOGENESIS CORPORATIONInventors: Joseph Khoury, Laurence B. Tarrant, Sean R. Kirkpatrick, Richard C. Svrluga
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Patent number: 7794590Abstract: Entrapping immobilization pellets for purifying breeding water in an aquarium to breed aquatic animals, wherein microorganisms are entrapped and immobilized in an aqueous polymer gel and the entrapping immobilization pellets are colored.Type: GrantFiled: June 21, 2007Date of Patent: September 14, 2010Assignee: Hitachi Plant Technologies, Ltd.Inventors: Shinichi Yoshikawa, Naoki Abe, Kazuichi Isaka
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Publication number: 20100227372Abstract: The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a plurality of cross-linked regions, as well as to such activated substrates that have been functionalised with a biological molecule and to devices comprising such functionalised substrates. Such substrates can be produced by a method comprising steps of: a.Type: ApplicationFiled: July 25, 2008Publication date: September 9, 2010Applicant: The University of SydneyInventors: Marcela Bilek, David McKenzie, Yongbai Yin
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Publication number: 20100215711Abstract: A medical device includes a base material having an immobilized fibrinolytic enzyme and dextran sulfate. The dextran sulfate has a molecular weight that is less than 40 kilo dalton (kDa). The medical device is formed from at least a base material. A fibrinolytic enzyme is immobilized on the base material. The fibrinolytic enzyme is stabilized with a dextran sulfate having a molecular weight of less than 40 (kDa).Type: ApplicationFiled: February 25, 2009Publication date: August 26, 2010Inventors: Nisha GUPTA, Joel Rosenblatt
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Publication number: 20100209982Abstract: Disclosed are preparations of modified interfacial enzymes, particularly lipases and phospholipases, immobilized on a solid support, wherein the enzyme is surrounded by hydrophobic microenvironment, thereby protected from deactivation and/or aggregation in the presence of hydrophilic agents, substrates and/or reaction products. The enzyme may be protected by being covalently bonded with lipid groups which coat the enzyme, or by being immobilized or embedded in a hydrophobic solid support. Also disclosed are processes for the preparation of the hydrophobically protected enzymes. The enzymes may be efficiently used in the preparation of biodiesel.Type: ApplicationFiled: May 7, 2008Publication date: August 19, 2010Applicant: TRANSBIODIESEL LTD.Inventor: Sobhi Basheer
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Publication number: 20100196985Abstract: A system and method capable of hydrolyzing lactose, where the system includes a support formed from a functionalized hydrophobic polymer that is covalently linked to a hydrophilic molecule covalently that is, in turn, covalently linked to an enzyme such as lactose. The method includes the steps of functionalizing a hydrophobic polymer support, covalently linking a hydrophilic molecule to said functionalized polymer support, and covalently linking an enzyme such as lactase to said hydrophilic molecule. The system and method generally relate to the field of food science and engineering and, more particularly to dairy-based food products and their production including solutions to problems associated with lactose intolerance such as product processing methods and products produced by these methods.Type: ApplicationFiled: June 18, 2008Publication date: August 5, 2010Applicant: CORNELL UNIVERSITYInventors: Joseph H. Hotchkiss, Joey N. Talbert
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Publication number: 20100190257Abstract: The present invention provides a fabrication method for the formation of a cell-microparticle hybrid. A biotin-avidin binding system also employs the use of a biodegradable polymer and any cell type that self-assemble to form a hybrid system.Type: ApplicationFiled: January 25, 2009Publication date: July 29, 2010Inventors: Aliasger K. Salem, Yogita Krishnamachari
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Publication number: 20100189706Abstract: The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ?-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.Type: ApplicationFiled: January 30, 2008Publication date: July 29, 2010Inventors: Cathy Chang, Justin T. Stege, Nahla Aboushadi, Gordana Djordjevic, Ellen Burke, Peter Luginbuhl, Mark Dycaico, Toby Richardson, John Poland, Ying Hefner, Stacy Marie Miles
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Patent number: 7763423Abstract: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.Type: GrantFiled: September 30, 2005Date of Patent: July 27, 2010Assignee: Pacific Biosciences of California, Inc.Inventors: Daniel Roitman, Paul Peluso, Mathieu Foquet