Carrier Is Synthetic Polymer Patents (Class 435/180)
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Patent number: 8535924Abstract: A granule with an allergenic component has reduced dust by including antifoam added during the production of the granule. The antifoam may be dispersed throughout the granule or added to one of the components of the granule. The granule with antifoam produces at least 30% less dust than a comparable granule produced according to a process in which no antifoam is added.Type: GrantFiled: November 3, 2011Date of Patent: September 17, 2013Assignee: Danisco US Inc.Inventors: Douglas A. Dale, Thomas S. Green
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Publication number: 20130236416Abstract: The present invention generally relates to surface modified colloidal particles. The invention further relates to methods of preparing and methods of using the same.Type: ApplicationFiled: March 7, 2013Publication date: September 12, 2013Applicant: Clemson UniversityInventors: Parul Rungta, Michael Daniele, JR., Stephen H. Foulger, Ragini Jetty
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Patent number: 8530212Abstract: A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -LB-WB; and (b) either: (i) when WA or WB comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when WA or WB comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor into anType: GrantFiled: August 22, 2007Date of Patent: September 10, 2013Assignee: ISIS Innovation LimitedInventors: Mark Moloney, Jon-Paul Griffiths
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Publication number: 20130224825Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: ApplicationFiled: March 21, 2013Publication date: August 29, 2013Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventor: 3M INNOVATIVE PROPERTIES COMPANY
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Patent number: 8518682Abstract: A tissue engineering composition adapted for application to an interior surface of a body lumen of a patient. The composition comprises (a) a carrier medium that is adapted to flow and to stably adhere the composition to the body lumen and (b) microcapsules, which are dispersed within the carrier medium and which contain one or more living cells encapsulated within a coating that includes a biodegradable polymer. The composition promotes growth of the cells on the lumen surface subsequent to application of the composition to the lumen.Type: GrantFiled: December 13, 2010Date of Patent: August 27, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Toby M. Freyman, Joseph A. Levendusky
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Patent number: 8512728Abstract: A method for in situ formation of a medical device on biological tissue includes attaching a plurality of reactive members of a primary specific binding pair to a surface of the biological tissue, and providing a plurality of fibers having attached thereto a plurality of complementary reactive members of the primary specific binding pair, wherein upon contact of the reactive members on the surface of the biological tissue with the complimentary reactive members on the fibers, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the fibers to the tissue. The fibers can incorporate functionalities which may cause them to bind to one another.Type: GrantFiled: February 19, 2010Date of Patent: August 20, 2013Assignee: Sofradim ProductionInventors: Sebastien Ladet, Philippe Gravagna
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Patent number: 8513024Abstract: Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized on a sensing element and with a second target substance trapping member immobilized on a gel particle to hold the gel particle on the sensing element; adjusting a magnetic marker precursor including the gel particle and a magnetic material precursor existing in the gel particle by bringing the magnetic material precursor into contact with the gel particle; synthesizing a magnetic material from the magnetic material precursor held on the gel particle, thereby adjusting the magnetic markers; and detecting the magnetic markers with the sensing element.Type: GrantFiled: February 4, 2009Date of Patent: August 20, 2013Assignee: Canon Kabushiki KaishaInventor: Kazumichi Nakahama
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Patent number: 8507256Abstract: Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material, the synzyme coating having bucket-shaped molecules for the sorption and degradation of the threat agents. A binding agent is configured for synzyme immobilization to maximize loading and retention of the synzyme coating on the material.Type: GrantFiled: June 17, 2010Date of Patent: August 13, 2013Assignee: Foster-Miller, Inc.Inventors: Yongwoo Lee, Tomasz Modzelewski, John P. Puglia, Steven E. Weiss, Robert A. Reinstein
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Patent number: 8507255Abstract: Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material configured for the degradation of the threat agents, the synzyme coating including bucket-shaped molecules configured for the sorption of the threat agents A binding agent is configured for synzyme immobilization to maximize loading and retention of the synzyme coating on the material.Type: GrantFiled: June 17, 2010Date of Patent: August 13, 2013Assignee: Foster-Miller, Inc.Inventors: Yongwoo Lee, Tomasz Modzelewski, John P. Puglia, Steven E. Weiss, Robert A. Reinstein
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Publication number: 20130199977Abstract: The present disclosure relates to a technique for inhibiting biofouling of the surface of a membrane caused by a biofilm, through immobilizing biofilm formation-inhibiting microorganisms to a container in a membrane process for water treatment. The present disclosure provides a container with biofilm formation-inhibiting microorganisms immobilized therein, including a permeable container and biofilm formation-inhibiting microorganisms immobilized in of the container. The present disclosure also provides a membrane water treatment apparatus comprising a reactor accommodating water to be treated, a membrane module for water treatment and a container with biofilm formation-inhibiting microorganism immobilized therein placed in the reactor.Type: ApplicationFiled: October 14, 2011Publication date: August 8, 2013Applicant: SNU R & DB FOUNDATIONInventors: Chung-Hak Lee, Hyun-Suk Oh, Sang Ryoung Kim, Jung-Kee Lee, Son-Young Park
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Publication number: 20130203147Abstract: A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.Type: ApplicationFiled: January 31, 2013Publication date: August 8, 2013Applicant: ABBOTT DIABETES CARE INC.Inventor: ABBOTT DIABETES CARE INC.
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Patent number: 8501399Abstract: A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.Type: GrantFiled: July 12, 2010Date of Patent: August 6, 2013Assignee: ANP Technologies, Inc.Inventors: Ray Yin, Dujie Qin, Jing Pan
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Patent number: 8497107Abstract: A composition of enzyme, polymer, and crosslinker forms a network of covalently bound macromolecules. The covalently immobilized enzyme preparation has enzymatic activity, and retains stable activity when dried and stored at ambient conditions. Methods for preparing an immobilized enzyme and methods for using the enzyme are disclosed.Type: GrantFiled: September 2, 2009Date of Patent: July 30, 2013Assignee: Fresenius Medical Care Holdings, Inc.Inventor: Stephen A. Merchant
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Publication number: 20130183734Abstract: A phospholipase-phospholipase-carrier complex for degumming crude oils. The phospholipase-carrier complex includes at least one phospholipase A1, A2 or B and at least one carrier, such as silicic acid, precipitated silicic acid, polyacrylate, polymethacrylate or divinylbenzene-crosslinked methacrylate. The disclosure further relates to a method of degumming crude oils and to a method of producing the phospholipase-carrier complex.Type: ApplicationFiled: December 28, 2012Publication date: July 18, 2013Applicant: CLARIANT PRODUKTE (DEUTSCHLAND) GMBHInventor: Clariant Produkte (Deutschland) GmbH
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Publication number: 20130180915Abstract: The present invention is directed to a composition for triggering microbiological processes in water, to a kit of parts comprising the components of said composition in distinct form, a method of producing such a composition and the use thereof for microbiologically decomposing water-immiscible substances, in particular crude oil and crude oil-derived substances.Type: ApplicationFiled: July 14, 2011Publication date: July 18, 2013Applicant: Lavaris Technologies GmbHInventor: Thomas Willuweit
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Patent number: 8486677Abstract: The invention is directed to enzyme preparations which are obtainable by providing enzyme immobilizates which comprise enzymes or microorganisms comprising enzymes immobilized on an inert support with a polyethersilicone coating obtained by hydrosilylation, to a process for preparing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst.Type: GrantFiled: September 1, 2009Date of Patent: July 16, 2013Assignee: Evonik Goldschmidt GmbHInventors: Oliver Thum, Marion Ansorge-Schumacher, Lars Wiemann, Michael Ferenz, Matthias Naumann
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Patent number: 8486676Abstract: The invention discloses a carrier made from an organic foam having open pores for enzymes or cells immobilization and the methods for preparing immobilized enzymes or cells. The invention uses flocculation and crosslinking technology to immobilize enzyme protein or cells on the organic foam material having open pores. The resultant immobilized products have larger specific surface area, higher specific activity and can be made into various shapes.Type: GrantFiled: September 25, 2006Date of Patent: July 16, 2013Assignee: Bioright Worldwide Company LimitedInventors: Caike Jin, Jun Wang
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Publication number: 20130172705Abstract: The present invention is broadly concerned with the crafting and manufacturability of an implantable enzymatic-based sensor characterized by a small size, optimum geometry, linearity of response over the concentration range of interest, extended shelf-life, selectivity for the analyte in question, and the ability to exclude bioactive interferents. More particularly, it is preferably concerned with a general approach to optimize the performance of the biorecognition elements required to produce biosensors of the type designed to provide, and in conjunction with a suitable signal processing unit, a current which is proportional to the concentration of the analyte of interest. The biosensors described herein may be implanted in vivo, including intra-cerebral, sub-cutaneous, intra-muscular, inter-peritoneal oral, serum, and vascular implantation, the majority of which may act as a surrogate for systemic monitoring and used to monitor analytes of interest in real-time.Type: ApplicationFiled: September 12, 2011Publication date: July 4, 2013Applicant: PINNACLE TECHNOLOGY, INC.Inventors: Peter A. Petillo, Daniel V. Aillon, Brian S. Barrett
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Publication number: 20130165525Abstract: The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface.Type: ApplicationFiled: February 21, 2013Publication date: June 27, 2013Applicant: The Clorox CompanyInventor: The Clorox Company
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Patent number: 8460907Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acrylic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.Type: GrantFiled: November 11, 2010Date of Patent: June 11, 2013Assignee: ICx-AgentaseInventors: Jeremy P. Walker, Anna M. Leech
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Patent number: 8460546Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.Type: GrantFiled: June 16, 2011Date of Patent: June 11, 2013Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Eli Weinberg, Jeffrey T. Borenstein
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Publication number: 20130137156Abstract: An artificial tissue capable of carrying necessary nutrients for maintaining activities of cells and tissues, and method of manufacturing artificial blood vessel. A plurality of forms of blood vessels are extracted from an image of living tissue and made into blood vessel form image. Each of the blood vessel forms of the blood vessel form image is adjusted and a blood vessel formation pattern is formed. A blood vessel cell culturing pattern of forming is formed, in a cell culturing layer. The blood vessel cell culturing pattern includes: a cell adhesion portion having adhesive properties with blood vessel cell and formed to the blood vessel formation pattern; and a cell adhesion-inhibiting portion having cell adhesion-inhibiting properties for inhibiting adhesion with a blood vessel cell and formed in an area other than the cell adhesion portion. A blood vessel cell is adhered to the cell adhesion portion, and cultured into tissue.Type: ApplicationFiled: January 3, 2013Publication date: May 30, 2013Applicant: DAI NIPPON PRINTING CO., LTD.Inventor: DAI NIPPON PRINTING CO., LTD.
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Publication number: 20130130265Abstract: A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.Type: ApplicationFiled: November 19, 2012Publication date: May 23, 2013Inventors: Bhairavi PARIKH, Michael D. BRODY, James STONE, Brian AWABDY, Urvi VED, Anh TRAN, David J. ANVAR
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Textile-Templated Electrospun Anisotropic Scaffolds for Tissue Engineering and Regenerative Medicine
Publication number: 20130131830Abstract: The present invention includes an anisotropic scaffold, which is prepared by electrospinning a solution of matrix material upon a textile template. The present invention further includes a method of preparing such scaffold. The anisotropic scaffold of the invention finds use in tissue engineering and regenerative medicine.Type: ApplicationFiled: May 23, 2011Publication date: May 23, 2013Applicant: Philadelphia UniversityInventors: Peter I. Lelkes, H. Gozde Senel, David Brookstein, Muthu Govindaraj -
Patent number: 8444968Abstract: The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.Type: GrantFiled: December 7, 2006Date of Patent: May 21, 2013Assignee: Isto Technologies, Inc.Inventors: Mitchell S. Seyedin, Matthew Matava
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Publication number: 20130122565Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.Type: ApplicationFiled: November 2, 2012Publication date: May 16, 2013Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventor: Georgia State University Research Foundation, Inc
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Patent number: 8440441Abstract: A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain comprising: a moiety R that is chemically coupled to the substrate, said moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker comprising at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.Type: GrantFiled: February 18, 2011Date of Patent: May 14, 2013Assignee: Temasek PolytechnicInventors: Christian Bluchel, Yanmei Wang
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Patent number: 8426176Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer.Type: GrantFiled: May 27, 2010Date of Patent: April 23, 2013Assignee: Corning IncorporatedInventors: Sophie Deshayes, David Henry, Martial Hervy
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Patent number: 8426192Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.Type: GrantFiled: December 14, 2009Date of Patent: April 23, 2013Assignee: Instrumentation Laboratory CompanyInventors: Prasad Pamidi, Sohrab Mansouri, Melanie Shin, Vasile Cosofret, Clarke Xu
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Publication number: 20130095497Abstract: Provided are a microorganism for use in quantification of homocysteine and methionine and a method of quantifying homocysteine and methionine in a sample by using the microorganism.Type: ApplicationFiled: May 20, 2010Publication date: April 18, 2013Applicant: LABGENOMICS CO., LTD.Inventors: Hyun Gyu Park, Min-Ah Woo, Moon Il Kim, Sang-Joon Hwang, Dae-Yeon Cho
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Patent number: 8420891Abstract: Disclosed is a method for introducing a foreign substance (3) into a cell (1) having a cell wall. The method comprises the steps of: providing a carbon nanotube (2) carrying at least one enzyme capable of decomposing a cell wall; supplying the carbon nanotube (2) and the foreign substance (3) into a treatment solution containing the cell (1); decomposing the cell wall of the cell (1) by the action of the enzyme carried on the carbon nanotube (2) upon the contact of the carbon nanotube (2) with the cell (1); and introducing the foreign substance (3) into the cell (1) through a site decomposed with the enzyme on the cell wall.Type: GrantFiled: June 11, 2008Date of Patent: April 16, 2013Assignee: National University Corporation Nagoya UniversityInventors: Yoshinobu Baba, Manabu Tokeshi, Noritada Kaji, Ibrahim Maged Fouad Serag Eldin Bayoumi
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Patent number: 8415124Abstract: A method for producing an immobilized enzyme which includes the steps of immobilizing an enzyme used for hydrolyzing fats and oils on a immobilization carrier by adsorption, bringing the immobilized enzyme into contact with an organic solvent in which fat-soluble fatty acids or the derivatives thereof have been dissolved, and adjusting the moisture content of the immobilized enzyme from 1 to 20% by weight based on the weight of the carrier.Type: GrantFiled: July 20, 2010Date of Patent: April 9, 2013Assignee: Kao CorporationInventors: Manabu Sato, Kazuhiro Onozuka, Takaaki Watanabe, Hiroyuki Konishi
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Publication number: 20130078647Abstract: Methods are provided to detect changes in cells without the use of detection labels.Type: ApplicationFiled: October 30, 2012Publication date: March 28, 2013Applicant: X-BODY, INC.Inventor: X-Body, Inc.
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Patent number: 8404469Abstract: A biodegradable material, capable of carrying a bioactive agent, comprising a polymer matrix and an enzyme capable of degrading the polymer matrix to enable the release of the bioactive agent.Type: GrantFiled: August 7, 2008Date of Patent: March 26, 2013Assignee: Polytechnic Institute of New York UniversityInventors: Richard A. Gross, Rachna Dave, Arthur Martin, Manoj Genesh
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Patent number: 8404470Abstract: The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst.Type: GrantFiled: July 7, 2008Date of Patent: March 26, 2013Assignee: Evonik Goldschmidt GmbHInventors: Oliver Thum, Marion Ansorge-Schumacher, Lars Wiemann, Andreas Buthe
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Publication number: 20130065291Abstract: Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: ApplicationFiled: September 9, 2011Publication date: March 14, 2013Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota, Department of Bioproducts & Biosystems Engineering, Toyota Motor CorporationInventors: Hongfei Jia, Ping Wang, Liting Zhang, Andreas Buthe, Xueyan Zhao, Songtao Wu, Masahiko Ishii, Minjuan Zhang
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Patent number: 8388994Abstract: The present invention relates to biocompatible non-woven fibrous materials having a nano-micro topography and methods for producing such materials. The materials may be used to cover implantable medical devices and to fabricate a three-dimensional drug-eluting fibrous matrix featuring accurate spatial positioning of the drug particles within the matrix.Type: GrantFiled: June 9, 2009Date of Patent: March 5, 2013Inventors: Ingo Scheer, Claudia Beaumont
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Publication number: 20130052179Abstract: The present invention relates to an arginine deiminase mutant with partial lysine-deficient and preparation and application thereof. The arginine deiminase mutant of the present invention has enzymatic activity of degrading arginine into citruline; compared with the arginine deiminase with the amino acid sequence of SEQ ID NO: 1, the amino acid sequence comprises one or more of K9N, T, K59Q, K66R, A, K93E, A, Q, K111R, A, K119Q, L, M, K121Q, I, K122E, L, K126E, S, R, K178I, E, D, K196I, R, K209G, T, D, K243E, V, R, K249D, Q, K263N, Q, K279Y, T, K293R, H, E, K325V, I, K380T, R, E, and K406E, D, S substitutions. Compared with PEG modified natural derived arginine deiminase, the PEG modified arginine deiminase mutant of the present invention retain better bioactivity; and because the quantity of lysine in arginine deiminase is reduced, the PEG modified products are more uniform and can be applied to clinical treatment of hepatoma, melanoma and the like.Type: ApplicationFiled: August 22, 2011Publication date: February 28, 2013Inventors: Yanshan HUANG, Jiwan Qiu, Xiaoyu Fu, Min Fan, Yujiao Wang, Yefei Wang
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Patent number: 8383380Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.Type: GrantFiled: October 6, 2011Date of Patent: February 26, 2013Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander
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Patent number: 8383378Abstract: Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.Type: GrantFiled: October 9, 2006Date of Patent: February 26, 2013Assignee: The Regents of the University of CaliforniaInventors: Yuli Wang, Mark Bachman, Christopher E. Sims, Guann-Pyng Li, Nancy Allbritton
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Patent number: 8383361Abstract: A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.Type: GrantFiled: December 14, 2011Date of Patent: February 26, 2013Assignee: Abbott Diabetes Care Inc.Inventors: Adam Heller, Benjamin J. Feldman, Nicolas Mano, Yueh-Lin Loo
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Patent number: 8383782Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: October 30, 2009Date of Patent: February 26, 2013Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Patent number: 8367809Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: October 30, 2009Date of Patent: February 5, 2013Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Publication number: 20130029384Abstract: The present invention relates to a sucrose phosphorylase from Bifidobacterium adolescentis which is useful as a biocatalyst in carbohydrate conversions at high temperatures. Indeed, the biocatalysts of the present invention are enzymatically active for a time period of at least 16 h and up to 1 to 2 week(s) at a temperature of at least 60° C. The biocatalysts of the present invention are: a) immobilized on an enzyme carrier, or b) are part of a cross-linked enzyme aggregate (CLEA), and/or c) are mutated, and/or d) are enzymatically active in the continuous presence of their substrate.Type: ApplicationFiled: April 1, 2011Publication date: January 31, 2013Applicant: UNIVERSITEIT GENTInventors: An Cerdobbel, Tom Desmet, Wim Soetaert
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Publication number: 20130029398Abstract: This invention is made to provide a formed article which ensures, for example, that an active substance included therein and a substance outside capsules can effectively come in contact with each other without suffering influences such as a pressure loss. This invention is a formed article having a plurality of cells formed in a polymer (A), (1) each cell including an active substance, (2) the polymer (A) having pores, each pore communicating with other pores and having a diameter in the range of 1 nm to 1 ?m, and (3) the internal wall of each cell and the active substance being substantially not in contact with each other.Type: ApplicationFiled: October 4, 2012Publication date: January 31, 2013Applicant: TEIJIN ENGINEERING LTD.Inventor: Teijin Engineering Ltd.
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Publication number: 20130023026Abstract: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond.Type: ApplicationFiled: May 24, 2012Publication date: January 24, 2013Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jean-Luc Popot, Delphine Charvolin, Fabrice Giusti
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Patent number: 8354477Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: August 3, 2010Date of Patent: January 15, 2013Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
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Patent number: 8354274Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.Type: GrantFiled: January 30, 2009Date of Patent: January 15, 2013Assignee: Geron CorporationInventors: Andrei Gennadyevich Fadeev, Jennifer Gehman, Zara Melkoumian, David Michael Weber, Yue Zhou
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Patent number: 8354259Abstract: A system and method capable of hydrolyzing lactose, where the system includes a support formed from a functionalized hydrophobic polymer that is covalently linked to a hydrophilic molecule covalently that is, in turn, covalently linked to an enzyme such as lactose. The method includes the steps of functionalizing a hydrophobic polymer support, covalently linking a hydrophilic molecule to said functionalized polymer support, and covalently linking an enzyme such as lactase to said hydrophilic molecule. The system and method generally relate to the field of food science and engineering and, more particularly to dairy-based food products and their production including solutions to problems associated with lactose intolerance such as product processing methods and products produced by these methods.Type: GrantFiled: June 18, 2008Date of Patent: January 15, 2013Assignee: Cornell UniversityInventors: Joseph H. Hotchkiss, Joey N. Talbert
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Publication number: 20130012597Abstract: The present invention provides a UCST-type thermoresponsive polymer compound which responds to a temperature under physiological conditions and has biofunctionality, and various uses thereof as a thermoresponsive material. Specifically, the invention provides a thermoresponsive material containing, as an active ingredient, a polymer compound represented by Formula (I) below or an addition salt thereof, the thermoresponsive material having an upper critical solution temperature in the range of 5 to 50° C. in an aqueous solution with a salt concentration of at least 1 mM and a pH in the range of 3 to 10.5: wherein m represents an integer of 10 or more; n represents a number satisfying 0.4?n?1; R1 represents hydrogen or succinyl; and R2 represents carbamoyl.Type: ApplicationFiled: March 22, 2011Publication date: January 10, 2013Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Naoko Shimada, Atsushi Maruyama