Carrier-bound Or Immobilized Enzyme Or Microbial Cell; Carrier-bound Or Immobilized Cell; Preparation Thereof Patents (Class 435/174)
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Patent number: 12146128Abstract: The invention relates to devices for the culture of cellular aggregates, the device comprising abase plate (1) with inlet (21) and outlet (22) openings for delivery and removal of media wherein inlet and outlet openings are in fluidic connection with respectively inlet and outlet ports in the base plate, and comprising a plurality of channels of a biocompatible liquid- and gas-permeable material, wherein each of said channels is connected at one end to an inlet opening and at the other end to an outlet opening, characterized in that each channel extends at one end (31) upwards from the inlet opening, and extend at the other end upwards (32) from the outlet opening.Type: GrantFiled: June 26, 2019Date of Patent: November 19, 2024Assignee: Katholieke Universiteit LeuvenInventors: Sergii Grebeniuk, Adrian Ranga
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Patent number: 12150326Abstract: A display device includes: ferritin encaging a first quantum dot and modified with a first peptide bound to a first pixel electrode; and ferritin encaging a second quantum dot and modified with a second peptide bound to a second pixel electrode. A first metal material and a second metal material are of different types.Type: GrantFiled: October 2, 2019Date of Patent: November 19, 2024Assignee: SHARP KABUSHIKI KAISHAInventors: Hirofumi Yoshikawa, Tatsuya Ryohwa, Masumi Kubo, Takahiro Doe, Masaki Yamamoto
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Patent number: 12138609Abstract: Described herein are coated chloride salt particles, including NaCl/TiO2 and NaCl/SiO2 core/shell particles, along with methods of making and using the same.Type: GrantFiled: November 18, 2022Date of Patent: November 12, 2024Assignees: Khalifa University of Science and Technology, National Center of MeteorologyInventors: Linda Yuan Zou, Mustapha Jouiad, Abdelali Zaki, Nabil El Hadri, Haoran Liang
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Patent number: 11993766Abstract: In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects. Described herein are surface modifying and surface functionalizing reagents, preparation thereof, and methods for modifying surfaces of wells within a well plate to activate lymphocytes, including but not limited to T lymphocytes, in a controllable and reproducible manner.Type: GrantFiled: September 20, 2019Date of Patent: May 28, 2024Assignee: BRUKER CELLULAR ANALYSIS, INC.Inventors: Peter J. Beemiller, Alexander J. Mastroianni, Randall D. Lowe, Jr., Yelena Bronevetsky
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Patent number: 11964044Abstract: One aspect of the present disclosure relates to a phase transfer cosmetic composition. According to the present disclosure, there can be provided a cosmetic composition which contains a wax having a melting point of 40 to 60° C. and an inulin-based surfactant, wherein the composition maintains a liquid state before applied to the skin and rubbed, and changes to a solid state when applied to the skin, can solve the problems in terms of hygiene and use because it is not used by scooping it by hand, and further, changes its phase to a solid state when applied to the skin and then rubbed, and thus, can solve the problem of dripping when applied to face or skin.Type: GrantFiled: October 30, 2020Date of Patent: April 23, 2024Assignee: Amorepacific CorporationInventors: Dong Wan Ha, Yu Jung Kim, Dong Won Choi, Yoon Kyun Hwang
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Patent number: 11911711Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: GrantFiled: October 6, 2022Date of Patent: February 27, 2024Assignee: Cytiva BioProcess R&D ABInventor: Klaus Gebauer
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Patent number: 11879048Abstract: Sealants and caulks (i.e., polymeric fillers) disclosed herein are polymeric fillers that comprises a polymeric material composition and one or more lipolytic enzymes dispersed within the polymeric material composition. In preferred embodiments, the polymeric material composition is an acrylic latex sealant such as that in the form of a caulk and the one or more lipolytic enzymes comprises a lipase such as, preferably, a triacylglycerol lipase. Advantageously, the one or more lipolytic enzymes of such sealants and caulks degrades lipid-containing contaminants and resulting lipid-containing stains that contain lipids. The degradation is a result of the ability of a lipolytic enzyme to catalyze a reaction on a lipid-containing substance (i.e., a substrate) to hydrolyze or move (e.g., intra-esterification) ester bonds of such lipid-containing substance. This lipid-degradation functionality at least partially inhibits the growth of such mold and mildew resulting from exposure to lipid-containing contaminants.Type: GrantFiled: February 3, 2021Date of Patent: January 23, 2024Assignee: REACTIVE SURFACES LTD., LLPInventor: Claude Steven McDaniel
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Patent number: 11833271Abstract: An antibacterial medical biomaterial includes an acellular small intestinal submucosal matrix material, an antibacterial gel layer located on a surface of the acellular small intestinal submucosal matrix material, and an absorbable fiber layer located on a surface of the antibacterial gel layer. Sulfadiazine silver is on the surface of the acellular small intestinal submucosal matrix material and/or within the acellular small intestinal submucosal matrix material. An absorbable fiber layer to which the sulfadiazine silver is attached, wherein the content of sulfadiazine silver in the absorbable fiber is 1 wt. %˜2 wt. %. The medical biomaterial is usable as an external medicine for treating wound infections relayed by burns or wounds, and for reducing the incidence of infection by using a conventional central venous catheter with a sulfadiazine silver antibacterial coating, so that the medical biomaterial loaded with sulfadiazine silver also has antibacterial activity consistent with sulfadiazine silver.Type: GrantFiled: September 27, 2022Date of Patent: December 5, 2023Assignee: B. J. ZH. F. PANTHER MEDICAL EQUIPMENT CO., LTD.Inventor: Qing Liu
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Patent number: 11806671Abstract: Mass transfer packing with a minimal surface or a triply periodic minimal surface which enables significantly improved performance for separation and mixing applications particularly with respect to distillation, liquid-liquid contacting, and heat exchange applications.Type: GrantFiled: February 4, 2020Date of Patent: November 7, 2023Assignee: GEOSEPAA LLCInventor: Robert C. Ryan
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Patent number: 11808765Abstract: Provided are a method and device for detecting an excessive antigen concentration, and a storage medium. The method includes: subjecting a sample containing antigens to an immune reaction, obtaining a photovoltage value of the sample after subjected to the immune reaction; and determining whether an antigen concentration of the sample is excessive according to the photovoltage value of the sample.Type: GrantFiled: June 11, 2019Date of Patent: November 7, 2023Assignee: EDAN INSTRUMENTS, INC.Inventors: Quan Gan, Lifeng Zhao, Yawen Han
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Patent number: 11802306Abstract: Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.Type: GrantFiled: October 12, 2018Date of Patent: October 31, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ting Pang, Michael Springer
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Patent number: 11786899Abstract: A microfluidic device including at least one channel in fluid communication with a sample trap array. Specifically, the configuration and geometry of the trap arrays according to the present invention allows for performing sample digitization that supports passive self-discretization within the sample traps without the need for any external flow control or actuation. Geometrical parameters defining the sample traps, including the trap width and the trap depth, are selected to optimize self-filling of the sample traps. Reagents are incorporated into the sample traps during device fabrication to allow for performing multiplexed reactions within the sample traps.Type: GrantFiled: February 2, 2018Date of Patent: October 17, 2023Assignee: University of Maryland, College ParkInventors: Don L. DeVoe, Alex Sposito
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Patent number: 11759753Abstract: The present invention provides enthalpy exchanger elements (E, E?) and enthalpy exchangers comprising such elements. Furthermore, the invention discloses a method for producing such enthalpy exchanger elements and enthalpy exchangers, comprising the steps of a) providing an air-permeable sheet element (1); b) laminating at least one side (1a, 1b) of the sheet element (1) with a thin polymer film (3, 4) with water vapor transmission characteristics; and c) forming the laminated sheet element (1) into a desired shape exhibiting a three-dimensional corrugation pattern (5, 5, . . . ).Type: GrantFiled: March 8, 2021Date of Patent: September 19, 2023Assignees: ZEHNDER GROUP INTERNATIONAL AG, SYMPATEX TECHNOLOGIES GMBHInventors: Christian Hirsch, Stefan Brandt, Christian Bier, Martin Mayershofer
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Patent number: 11739312Abstract: In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.Type: GrantFiled: December 2, 2020Date of Patent: August 29, 2023Assignees: BASF Enzymes LLC, Syngenta Participations AGInventors: Malgorzata Slupska, Geoff Hazlewood, Cathy Chang, Peter Luginbuhl, Ellen Burke, Michelle Cayouette, Uvini Gunawardena, Majid Ghassemian, Aron Silverstone, Yan Zhang
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Patent number: 11730798Abstract: The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g. cancer, by adenoviral vectors which have been coated by polypeptides causing peptide-specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.Type: GrantFiled: September 2, 2020Date of Patent: August 22, 2023Assignee: Valo Therapeutics OyInventors: Vincenzo Cerullo, Markus Vähä-Koskela, Mari Hirvinen, Cristian Capasso
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Patent number: 11697794Abstract: The present invention provides a method for swiftly producing a layered cell sheet that is non-invasively obtained and is utilizable for transplantation, etc., the method including (1) a step of applying a centrifugal force to a first cell sheet on a temperature-responsive culture surface for a predetermined time in a temperature range from a lower critical solution temperature of the temperature-responsive culture surface to 45° C., (2) a step of further placing a second cell sheet on the first cell sheet, and (3) a step of applying a centrifugal force to the first cell sheet and the second cell sheet on the temperature-responsive culture surface for a predetermined time in the temperature range from the lower critical solution temperature to 45° C.; and also provides a layered cell sheet obtained by the method.Type: GrantFiled: June 28, 2018Date of Patent: July 11, 2023Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Yuki Kagawa, Tatsuya Shimizu, Yuji Haraguchi, Hirotsugu Kubo
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Patent number: 11623025Abstract: Provided subject matter relates to tissue engineering. More specifically provided are kits, devices and methods for in situ repair and regeneration of guided and functional growth of cells and cell components by providing into the injury site biomaterial solution including the cell(s), magnetic particles and solidifying the biomaterial while applying the magnetic field.Type: GrantFiled: February 23, 2017Date of Patent: April 11, 2023Assignee: BAR ILAN UNIVERSITYInventors: Orit Shefi, Merav Antman-Passig
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Patent number: 11618929Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).Type: GrantFiled: June 19, 2018Date of Patent: April 4, 2023Assignee: Becton, Dickinson and CompanyInventors: Christina Fan, Stephen P. A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
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Patent number: 11604199Abstract: In a method for immunologically quantifying a steroid, it is possible to exclude a steroid from cyclodextrin when a standard solution containing the steroid included in cyclodextrin is treated with a surfactant, which thereby suppresses the deviation in behavior of the antigen-antibody reaction between the specimen (test sample) and the standard solution, and then significantly improves the accuracy of steroid quantification.Type: GrantFiled: November 16, 2018Date of Patent: March 14, 2023Assignee: FUJIREBIO INC.Inventors: Tatsunari Yoshimi, Kyoko Teruyama
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Patent number: 11577062Abstract: Embodiments of the present disclosure encompass systems and methods for in-situ/in vivo, bottom-up tissue generation for wound repair, repair of tissue defects, and the like. Embodiments of the systems of the present disclosure include modular scaffolds seeded with cells (modular tissue forming units (MTFUs)) for packing a tissue defect, such that these MTFUs are able to fill the wound bed with cells of one or more needed tissue types supported by the modular scaffolding particles.Type: GrantFiled: April 10, 2018Date of Patent: February 14, 2023Assignee: University of Florida Research Foundation, Inc.Inventor: Adam J. Katz
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Patent number: 11543415Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.Type: GrantFiled: June 3, 2019Date of Patent: January 3, 2023Assignee: Quest Diagnostics Investments IncorporatedInventors: Yanni Zhang, Nigel J. Clarke, Richard E Reitz
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Patent number: 11529570Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.Type: GrantFiled: November 24, 2020Date of Patent: December 20, 2022Assignee: Cytiva BioProcess R&D ABInventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
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Patent number: 11511254Abstract: The invention relates to a process for producing a plurality of capsules, each comprising an external shell of crosslinked hydrogel surrounding a central core, according to which a hydrogel solution and a composition of interest, intended to form the central core, are concentrically co-extruded so as to form mixed drops, each comprising a layer of hydrogel solution surrounding a drop of liquid composition of interest, characterized in that the co-extrusion step is carried out above a crosslinking aerosol so that the mixed drops pass through said crosslinking aerosol, such that the layer of hydrogel solution at least partially crosslinks around the drop of liquid composition of interest on contact with said aerosol.Type: GrantFiled: November 20, 2018Date of Patent: November 29, 2022Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT D'OBTIQUE THÉORIQUE ET APPLIQUÉEInventors: Maxime Feyeux, Kevin Alessandri, Pierre Nassoy
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Patent number: 11458221Abstract: Diatom microbubblers comprising diatom biosilica or other silica linked to a catalyst for the decomposition of hydrogen peroxide, such as manganese oxide (MnO2), platinum (Pt), CuO (copper II oxide), or zinc peroxide (ZnO2) particles or nanosheets, or catalase are provided. Further provided are methods of reducing or eliminating biofilm or biofouling conditions.Type: GrantFiled: August 14, 2019Date of Patent: October 4, 2022Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Hyunjoon Kong, Yongbeom Seo, Jiayu Leong, Yu-Heng Deng
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Patent number: 11440822Abstract: The present application discloses a method of binding a metal ion in water. The method comprises contacting the water with a fraction of dissolved organic material (DOM) to form a complex between the DOM fraction and the metal ion; and optionally separating the complex from the water. The present application also discloses a use of DOM for binding a metal ion in water.Type: GrantFiled: September 11, 2020Date of Patent: September 13, 2022Assignee: Noblegen, Inc.Inventors: Celine Gueguen, Vaughn Mangal
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Patent number: 11253797Abstract: The present invention relates to a chromatographic device for isolating and purifying nucleic acids, preferably genomic DNA, by gel filtration chromatography, a method for isolating and purifying nucleic acids, preferably genomic DNA, using this device and a kit comprising this device.Type: GrantFiled: July 7, 2016Date of Patent: February 22, 2022Assignee: QIAGEN GmbHInventors: Roland Fabis, Markus Müller, Jörg Hucklenbroich, Mario Scherer
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Patent number: 11248255Abstract: An automated multiplex detector system includes: (a) a nucleic acid amplification compartment for amplifying nucleic acid of one or more targets in a sample, and (b) an analysis compartment in fluid communication with the amplification compartment, the analysis compartment housing a nanoparticle-based multiplex detector capable of using the amplified nucleic acid of the amplification compartment and producing a signal that correlates with the presence of the one or more targets in the sample.Type: GrantFiled: June 17, 2016Date of Patent: February 15, 2022Assignee: The Governing Council of the University of TorontoInventors: Warren C. W. Chan, Jisung Kim, Kyrylo Zagorovsky
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Patent number: 11208632Abstract: Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) light chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig light chain polypeptide. An fGly-modified Ig light chain polypeptide of the antibody can be covalently and site-specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig light chain polypeptides, fGly-modified Ig light chain polypeptides, and antibody conjugates, as well as methods of use of same.Type: GrantFiled: April 24, 2017Date of Patent: December 28, 2021Assignee: R.P. Scherer Technologies, LLCInventors: Yun Cheol Kim, Chao Bai Huang, David Rabuka
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Patent number: 11167158Abstract: A method of custom manufacturing a flame arrestor includes providing a housing having an interior surface and an exterior surface where the exterior surface of the housing is shaped to fit within a fluid passageway. The method includes forming, using an additive manufacturing technique, a three-dimensional lattice structure by depositing a first material onto the interior surface of the housing in a predetermined pattern. The lattice structure includes a plurality of connected lattice members forming channels extending from a first end to a second end of the three-dimensional lattice structure. An element of a second material is provided adjacent to the three-dimensional lattice structure. The second material is different than the first material and the element is configured to draw heat away from fluid flowing through the plurality of channels.Type: GrantFiled: May 14, 2018Date of Patent: November 9, 2021Assignee: Emerson Process Management Regulator Technologies Tulsa, LLCInventors: John D. Cockerham, James Myers
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Patent number: 11099147Abstract: Disclosed are a gas sensor member, a gas sensor using the same, and manufacturing methods thereof, and specifically, a gas sensor member using a one-dimensional porous metal oxide nanotube composite material having a double average pore distribution in which mesopores (0.1 nm to 50 nm) and macropores (50 nm to 300 nm) are simultaneously formed on the surface of a nanotube through decomposition of a spherical polymer sacrificial template and continuous crystallization and diffusion of a metal oxide and a nanoparticle catalyst embedded in an apoferritin is uniformly loaded in the inside and on the outer wall and inner wall of a one-dimensional metal oxide nanotube through a high-temperature heat treatment, a gas sensor using the same, and manufacturing methods thereof are disclosed.Type: GrantFiled: March 13, 2019Date of Patent: August 24, 2021Assignee: Korea Advanced Institute of Science and TechnologyInventors: Il-Doo Kim, Ji Su Jang, Sang-Joon Kim, Seon-Jin Choi
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Patent number: 11046753Abstract: A method for conjugating an isolated antibody to a label or derivatisation reagent, which method comprises contacting the antibody with an activated label or activated derivatisation reagent, or contacting the antibody with the label or derivatisation reagent in the presence of an antibody conjugation reagent, in a buffer system which comprises a monocarboxylic acid buffer compound other than glycine, bearing an amine substituent at the alpha or beta position.Type: GrantFiled: May 30, 2014Date of Patent: June 29, 2021Assignee: INNOVA BIOSCIENCES LTD.Inventors: Nicolas Steven Gee, Bianca Fusetti
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Patent number: 10995911Abstract: A pressure vessel for storing hydrogen is described. The pressure vessel includes at least one chamber to store hydrogen atoms. The pressure vessel also includes a mycelium structure within the at least one chamber. The mycelium structure has a surface area of at least 800 m2/m3. At least some of the hydrogen atoms are attached to the mycelium structure at a pressure greater than ambient pressure. Methods of storing hydrogen and methods of constructing a hydrogen storage tank are also described.Type: GrantFiled: February 28, 2017Date of Patent: May 4, 2021Assignee: The Boeing CompanyInventors: Benjamin J. Stephenson, Jeffrey M. Hansen
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Patent number: 10996181Abstract: Provided is a sensor comprising a non-conductive substrate; and a conductive layer electronically printed on one side of the substrate, wherein the conductive layer comprises: an antenna pattern for transmitting and receiving a radio signal with an external device; a sensing electrode connected to the antenna pattern via a circular wiring for sensing an impedance change due to contact with a sensing target material; and a coating electrode stacked on the sensing electrode for removing an occurrence of noise of the impedance change. Accordingly, the present invention solves the problem of a sensor, in the form of a terminal, not being compact and the problem of high manufacturing costs and low manufacturing quality of a sensor manufactured using a deposition method in order to replace such sensor with a sensor manufactured by a printing method, and solves a corrosion problem of a sensing electrode, a durability problem, etc. that may occur in the sensor of the printing method.Type: GrantFiled: December 20, 2017Date of Patent: May 4, 2021Assignee: LG ELECTRONICS INC.Inventors: Hyunchul Kim, Myungwon Lee
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Patent number: 10927335Abstract: A microfluidic device includes a base comprising a chamber configured to receive a microfluidic component. A sealing member includes a body, an inlet reservoir, and an outlet reservoir, where the inlet reservoir and the outlet reservoir communicate with the chamber through fluid passages when the sealing member and base are removably coupled. A microfluidic component removably within the chamber includes microfluidic channels on a surface thereof and a tissue culture chamber coupled to at least one of the microfluidic channels. The microfluidic channels and the tissue culture chamber are in fluid communication with the inlet and outlet reservoirs through the fluid passages to form a fluid circuit for directing fluid from the inlet reservoir, through the tissue culture chamber, to the outlet reservoir, and from the outlet reservoir back to the inlet reservoir upon tilting the microfluidic device to a forward tilted position and to a reverse tilted position, respectively.Type: GrantFiled: October 3, 2016Date of Patent: February 23, 2021Assignee: Cornell UniversityInventor: Mandy Brigitte Esch
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Patent number: 10927419Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).Type: GrantFiled: May 23, 2018Date of Patent: February 23, 2021Assignee: Becton, Dickinson and CompanyInventors: Christina Fan, Stephen P. A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
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Patent number: 10875898Abstract: The present invention according to a first aspect relates to a Trichoderma longibrachiatum strain comprising an autologous nucleotide sequence coding for a protein having at least 70% sequence similarity with the amino acid sequence of SEQ ID NO: 1 and its use for the treatment of a plant. Further aspects of the invention relate to a protein derived from said strain, methods for producing the protein, the use of the protein for the treatment of a plant and compositions comprising a source of the protein of the invention. Yet Further aspects of the invention relate to seeds treated with a source of the protein and methods for growing plants incorporating the step of treating said plants with the composition of the invention.Type: GrantFiled: March 8, 2019Date of Patent: December 29, 2020Assignee: Koppert B.V.Inventors: Matteo Lorito, Michelina Ruocco, Francesco Vinale, Sheridan Lois Woo
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Patent number: 10851333Abstract: A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.Type: GrantFiled: January 29, 2018Date of Patent: December 1, 2020Assignee: Techshot, Inc.Inventors: John C. Vellinger, Eugene Boland, Michael A. Kurk, Krystal Milliner, Nester Samuel Logan
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Patent number: 10844425Abstract: Compositions, methods, kits, and uses are provided for detecting or quantifying an Human Parainfluenza virus 1 (HPIV-1), HPIV-2, HPIV-3, and/or HPIV-4 nucleic acid, e.g., using nucleic acid amplification and hybridization assays. In some embodiments, the compositions, methods, kits, and uses target the HN gene of HPIV-1, HPIV-2, and/or HPIV-3 and/or the NP gene of HPIV-4.Type: GrantFiled: March 23, 2018Date of Patent: November 24, 2020Assignee: Gen-Probe IncorporatedInventors: Mehrdad Majlessi, Pamela Douglass, Daniel Kolk
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Patent number: 10828399Abstract: The present disclosure is directed to methods of printing 3-D structures using supramolecular gels, and the structures that result therefrom.Type: GrantFiled: March 24, 2016Date of Patent: November 10, 2020Assignee: The Trustees of the University of PennsylvaniaInventors: Jason Alan Burdick, Chris Highley
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Patent number: 10815139Abstract: A material for reducing the content of polluting and/or unwanted substances in a liquid includes at least one polymeric and/or inorganic base, suitable to be immersed in the liquid, having at least a surface, whereto is bonded at least one catalyst of the degradation reaction of inorganic salts in gaseous substances. The catalyst, whose function is to reduce the energy required for the activation of said reaction and to accelerate its progress, is an enzyme preferably selected among the lyase group, the hydrolase group and the oxidoreductase group.Type: GrantFiled: September 25, 2017Date of Patent: October 27, 2020Assignee: ARCHIMEDE R&D S.R.L.Inventor: Lucio Panizza
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Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders
Patent number: 10654917Abstract: The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs.Type: GrantFiled: January 29, 2016Date of Patent: May 19, 2020Assignee: TECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SAInventors: Sofia Volker Côrte-Real, Vera Luísa Santos Neves, Pedro Manuel Correia Canhão, Tiago Fleming Outeiro, Miguel Augusto Rico Botas Castanho, Frederico Nuno Castanheira Aires Da Silva, Soraia Rafaela Santiago De Oliveira -
Patent number: 10626391Abstract: The invention provides granules comprising A) at least one enzyme selected from at least one of the groups selected from transferases of EC 2, hydrolases of EC 3, lyases of EC 4 and isomerases of EC 5, B) at least one polymer selected from C1-C10-alkyl acrylate polymer, C1-C10-alkyl methacrylate polymer and C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer, preferably C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer and C) at least one inorganic carrier material.Type: GrantFiled: March 3, 2015Date of Patent: April 21, 2020Assignee: Evonik Operations GmbHInventors: Frank Hellmers, Thomas Hueller, Thomas Dassinger, Oliver Thum
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Patent number: 10538443Abstract: The present invention relates to a method for degrading and inactivating at least one xenobiotic, the at least one xenobiotic being present in an aqueous medium. The method comprises the steps of (a) grafting at least one enzyme onto a solid support, (b) incubating the solid support with the at least one enzyme into the aqueous medium and (c) measuring the evolution of the concentration of the at least one xenobiotic. The method is remarkable in that the at least one enzyme is New-Dehli metallo-?-lactamase 1, a laccase extracted from Pleurotus ostreatus and/or a ?-lactamase extracted from Pseudomonas aeruginosa and in that the solid support is a moving bed carrier.Type: GrantFiled: December 14, 2015Date of Patent: January 21, 2020Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)Inventors: Sebastien Bonot, Henry-Michel Cauchie
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Patent number: 10525163Abstract: This invention relates to methods of producing collagen biomaterials by admixing (i) a solution of monomeric collagen, (ii) a solution of polymeric collagen, (ii) cargo particles, and (iv) a non-collagen blocking polymer, to produce a collagen solution. The collagen solution is then allowed to solidify to produce a collagen hydrogel. This may be useful in improving the stiffness of collagen hydrogel constructs and increasing the entrapment and retention of cargo particles.Type: GrantFiled: June 5, 2015Date of Patent: January 7, 2020Inventor: Josephine Wong
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Patent number: 10512696Abstract: The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.Type: GrantFiled: June 15, 2016Date of Patent: December 24, 2019Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Shiladitya Sengupta, Abhimanyu Paraskar, Shivani Soni, Sudipta Basu, Poulomi Sengupta
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Patent number: 10508297Abstract: The present invention provides an insoluble enzymatic reagent for detecting products derived from glucuronide metabolites in a sample, containing an enzyme with glucuronidase activity immobilized on a resin comprising a polysaccharide modified with chemical groups, and optionally a cationic polymer. Additionally, it provides methods for preparing said enzymatic reagent and for detecting derivatives of glucuronide metabolites in a sample, using said reagent.Type: GrantFiled: July 13, 2017Date of Patent: December 17, 2019Assignee: LA PIEDRA BIOTECNOLOGÍA SPAInventors: Manuel Rozas Andreu, Fernando Alexis Gutierrez Rojas, Rocio Andrea Peralta Villalobos
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Patent number: 10479971Abstract: A culture container has a first inflow port and a first outflow port. The first flow path connects the first outflow port to the first inflow port. A storage container is provided within the first flow path and has a second inflow port which is connected to the first outflow port and a second outflow port which is connected to the first inflow port. A second flow path connects a first region within the first flow path, and a second region within the first flow path. A division processing portion is provided within the second flow path, performs a division process of dividing a cell aggregation flowing in from the first flow path, and allows the cells subjected to the division process to flow out into the first flow path via the second region. A medium supply portion supplies a medium to the inside of the first flow path.Type: GrantFiled: July 14, 2017Date of Patent: November 19, 2019Assignee: FUJIFILM CORPORATIONInventors: Hideaki Kagawa, Shun Goto, Souichi Kohashi, Hidekazu Yamazaki
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Patent number: 10441610Abstract: Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.Type: GrantFiled: November 23, 2011Date of Patent: October 15, 2019Assignee: Georgia Tech Research CorporationInventors: Barbara Dale Boyan, Zvi Schwartz, Christopher S. D. Lee, Shirae Kerisha Leslie, Ramsey C. Kinney
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Patent number: 10436682Abstract: A Raman silent substrate includes a base and a biologically compatible material layer over the base. The biologically compatible material layer is Raman silent, provides a predetermined capture efficiency corresponding to a desired application, and supports biological culturing. In certain implementations, the base comprises a glass layer and an aluminum layer between the glass layer and the biologically compatible material layer.Type: GrantFiled: May 29, 2016Date of Patent: October 8, 2019Assignee: BATTELLE MEMORIAL INSTITUTEInventors: Andrew P. Bartko, Theodore J. Ronningen
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Patent number: 10435676Abstract: The present invention relates to a variant of Terminal deoxynucleotidyl Transferase (TdT) which (i) comprises the amino acid sequence as set forth in SEQ ID Nº 2 or a functionally equivalent sequence, with at least an amino acid substitution at position corresponding to residue C302 or functionally equivalent residue, wherein the position is numbered by reference to the amino acid sequence set forth in SEQ ID Nº 1, (ii) is able to synthesize a nucleic acid fragment without template and (iii) is able to incorporate a modified nucleotide into the nucleic fragment.Type: GrantFiled: January 8, 2019Date of Patent: October 8, 2019Inventors: Elise Champion, Mikhael Soskine, Thomas Ybert, Marc Delarue