Carrier-bound Or Immobilized Enzyme Or Microbial Cell; Carrier-bound Or Immobilized Cell; Preparation Thereof Patents (Class 435/174)
  • Patent number: 11911711
    Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Grant
    Filed: October 6, 2022
    Date of Patent: February 27, 2024
    Assignee: Cytiva BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Patent number: 11879048
    Abstract: Sealants and caulks (i.e., polymeric fillers) disclosed herein are polymeric fillers that comprises a polymeric material composition and one or more lipolytic enzymes dispersed within the polymeric material composition. In preferred embodiments, the polymeric material composition is an acrylic latex sealant such as that in the form of a caulk and the one or more lipolytic enzymes comprises a lipase such as, preferably, a triacylglycerol lipase. Advantageously, the one or more lipolytic enzymes of such sealants and caulks degrades lipid-containing contaminants and resulting lipid-containing stains that contain lipids. The degradation is a result of the ability of a lipolytic enzyme to catalyze a reaction on a lipid-containing substance (i.e., a substrate) to hydrolyze or move (e.g., intra-esterification) ester bonds of such lipid-containing substance. This lipid-degradation functionality at least partially inhibits the growth of such mold and mildew resulting from exposure to lipid-containing contaminants.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: January 23, 2024
    Assignee: REACTIVE SURFACES LTD., LLP
    Inventor: Claude Steven McDaniel
  • Patent number: 11833271
    Abstract: An antibacterial medical biomaterial includes an acellular small intestinal submucosal matrix material, an antibacterial gel layer located on a surface of the acellular small intestinal submucosal matrix material, and an absorbable fiber layer located on a surface of the antibacterial gel layer. Sulfadiazine silver is on the surface of the acellular small intestinal submucosal matrix material and/or within the acellular small intestinal submucosal matrix material. An absorbable fiber layer to which the sulfadiazine silver is attached, wherein the content of sulfadiazine silver in the absorbable fiber is 1 wt. %˜2 wt. %. The medical biomaterial is usable as an external medicine for treating wound infections relayed by burns or wounds, and for reducing the incidence of infection by using a conventional central venous catheter with a sulfadiazine silver antibacterial coating, so that the medical biomaterial loaded with sulfadiazine silver also has antibacterial activity consistent with sulfadiazine silver.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: December 5, 2023
    Assignee: B. J. ZH. F. PANTHER MEDICAL EQUIPMENT CO., LTD.
    Inventor: Qing Liu
  • Patent number: 11808765
    Abstract: Provided are a method and device for detecting an excessive antigen concentration, and a storage medium. The method includes: subjecting a sample containing antigens to an immune reaction, obtaining a photovoltage value of the sample after subjected to the immune reaction; and determining whether an antigen concentration of the sample is excessive according to the photovoltage value of the sample.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 7, 2023
    Assignee: EDAN INSTRUMENTS, INC.
    Inventors: Quan Gan, Lifeng Zhao, Yawen Han
  • Patent number: 11806671
    Abstract: Mass transfer packing with a minimal surface or a triply periodic minimal surface which enables significantly improved performance for separation and mixing applications particularly with respect to distillation, liquid-liquid contacting, and heat exchange applications.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: November 7, 2023
    Assignee: GEOSEPAA LLC
    Inventor: Robert C. Ryan
  • Patent number: 11802306
    Abstract: Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 31, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ting Pang, Michael Springer
  • Patent number: 11786899
    Abstract: A microfluidic device including at least one channel in fluid communication with a sample trap array. Specifically, the configuration and geometry of the trap arrays according to the present invention allows for performing sample digitization that supports passive self-discretization within the sample traps without the need for any external flow control or actuation. Geometrical parameters defining the sample traps, including the trap width and the trap depth, are selected to optimize self-filling of the sample traps. Reagents are incorporated into the sample traps during device fabrication to allow for performing multiplexed reactions within the sample traps.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: October 17, 2023
    Assignee: University of Maryland, College Park
    Inventors: Don L. DeVoe, Alex Sposito
  • Patent number: 11759753
    Abstract: The present invention provides enthalpy exchanger elements (E, E?) and enthalpy exchangers comprising such elements. Furthermore, the invention discloses a method for producing such enthalpy exchanger elements and enthalpy exchangers, comprising the steps of a) providing an air-permeable sheet element (1); b) laminating at least one side (1a, 1b) of the sheet element (1) with a thin polymer film (3, 4) with water vapor transmission characteristics; and c) forming the laminated sheet element (1) into a desired shape exhibiting a three-dimensional corrugation pattern (5, 5, . . . ).
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: September 19, 2023
    Assignees: ZEHNDER GROUP INTERNATIONAL AG, SYMPATEX TECHNOLOGIES GMBH
    Inventors: Christian Hirsch, Stefan Brandt, Christian Bier, Martin Mayershofer
  • Patent number: 11739312
    Abstract: In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: August 29, 2023
    Assignees: BASF Enzymes LLC, Syngenta Participations AG
    Inventors: Malgorzata Slupska, Geoff Hazlewood, Cathy Chang, Peter Luginbuhl, Ellen Burke, Michelle Cayouette, Uvini Gunawardena, Majid Ghassemian, Aron Silverstone, Yan Zhang
  • Patent number: 11730798
    Abstract: The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g. cancer, by adenoviral vectors which have been coated by polypeptides causing peptide-specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: August 22, 2023
    Assignee: Valo Therapeutics Oy
    Inventors: Vincenzo Cerullo, Markus Vähä-Koskela, Mari Hirvinen, Cristian Capasso
  • Patent number: 11697794
    Abstract: The present invention provides a method for swiftly producing a layered cell sheet that is non-invasively obtained and is utilizable for transplantation, etc., the method including (1) a step of applying a centrifugal force to a first cell sheet on a temperature-responsive culture surface for a predetermined time in a temperature range from a lower critical solution temperature of the temperature-responsive culture surface to 45° C., (2) a step of further placing a second cell sheet on the first cell sheet, and (3) a step of applying a centrifugal force to the first cell sheet and the second cell sheet on the temperature-responsive culture surface for a predetermined time in the temperature range from the lower critical solution temperature to 45° C.; and also provides a layered cell sheet obtained by the method.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: July 11, 2023
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Yuki Kagawa, Tatsuya Shimizu, Yuji Haraguchi, Hirotsugu Kubo
  • Patent number: 11623025
    Abstract: Provided subject matter relates to tissue engineering. More specifically provided are kits, devices and methods for in situ repair and regeneration of guided and functional growth of cells and cell components by providing into the injury site biomaterial solution including the cell(s), magnetic particles and solidifying the biomaterial while applying the magnetic field.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: April 11, 2023
    Assignee: BAR ILAN UNIVERSITY
    Inventors: Orit Shefi, Merav Antman-Passig
  • Patent number: 11618929
    Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: April 4, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Fan, Stephen P. A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
  • Patent number: 11604199
    Abstract: In a method for immunologically quantifying a steroid, it is possible to exclude a steroid from cyclodextrin when a standard solution containing the steroid included in cyclodextrin is treated with a surfactant, which thereby suppresses the deviation in behavior of the antigen-antibody reaction between the specimen (test sample) and the standard solution, and then significantly improves the accuracy of steroid quantification.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: March 14, 2023
    Assignee: FUJIREBIO INC.
    Inventors: Tatsunari Yoshimi, Kyoko Teruyama
  • Patent number: 11577062
    Abstract: Embodiments of the present disclosure encompass systems and methods for in-situ/in vivo, bottom-up tissue generation for wound repair, repair of tissue defects, and the like. Embodiments of the systems of the present disclosure include modular scaffolds seeded with cells (modular tissue forming units (MTFUs)) for packing a tissue defect, such that these MTFUs are able to fill the wound bed with cells of one or more needed tissue types supported by the modular scaffolding particles.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: February 14, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Adam J. Katz
  • Patent number: 11543415
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: January 3, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E Reitz
  • Patent number: 11529570
    Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: December 20, 2022
    Assignee: Cytiva BioProcess R&D AB
    Inventors: Klaus Gebauer, Manoj Kumar Ramakrishna, Daniel Salomonsson, Per Lofving
  • Patent number: 11511254
    Abstract: The invention relates to a process for producing a plurality of capsules, each comprising an external shell of crosslinked hydrogel surrounding a central core, according to which a hydrogel solution and a composition of interest, intended to form the central core, are concentrically co-extruded so as to form mixed drops, each comprising a layer of hydrogel solution surrounding a drop of liquid composition of interest, characterized in that the co-extrusion step is carried out above a crosslinking aerosol so that the mixed drops pass through said crosslinking aerosol, such that the layer of hydrogel solution at least partially crosslinks around the drop of liquid composition of interest on contact with said aerosol.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: November 29, 2022
    Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT D'OBTIQUE THÉORIQUE ET APPLIQUÉE
    Inventors: Maxime Feyeux, Kevin Alessandri, Pierre Nassoy
  • Patent number: 11458221
    Abstract: Diatom microbubblers comprising diatom biosilica or other silica linked to a catalyst for the decomposition of hydrogen peroxide, such as manganese oxide (MnO2), platinum (Pt), CuO (copper II oxide), or zinc peroxide (ZnO2) particles or nanosheets, or catalase are provided. Further provided are methods of reducing or eliminating biofilm or biofouling conditions.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: October 4, 2022
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Hyunjoon Kong, Yongbeom Seo, Jiayu Leong, Yu-Heng Deng
  • Patent number: 11440822
    Abstract: The present application discloses a method of binding a metal ion in water. The method comprises contacting the water with a fraction of dissolved organic material (DOM) to form a complex between the DOM fraction and the metal ion; and optionally separating the complex from the water. The present application also discloses a use of DOM for binding a metal ion in water.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: September 13, 2022
    Assignee: Noblegen, Inc.
    Inventors: Celine Gueguen, Vaughn Mangal
  • Patent number: 11253797
    Abstract: The present invention relates to a chromatographic device for isolating and purifying nucleic acids, preferably genomic DNA, by gel filtration chromatography, a method for isolating and purifying nucleic acids, preferably genomic DNA, using this device and a kit comprising this device.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: February 22, 2022
    Assignee: QIAGEN GmbH
    Inventors: Roland Fabis, Markus Müller, Jörg Hucklenbroich, Mario Scherer
  • Patent number: 11248255
    Abstract: An automated multiplex detector system includes: (a) a nucleic acid amplification compartment for amplifying nucleic acid of one or more targets in a sample, and (b) an analysis compartment in fluid communication with the amplification compartment, the analysis compartment housing a nanoparticle-based multiplex detector capable of using the amplified nucleic acid of the amplification compartment and producing a signal that correlates with the presence of the one or more targets in the sample.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 15, 2022
    Assignee: The Governing Council of the University of Toronto
    Inventors: Warren C. W. Chan, Jisung Kim, Kyrylo Zagorovsky
  • Patent number: 11208632
    Abstract: Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) light chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig light chain polypeptide. An fGly-modified Ig light chain polypeptide of the antibody can be covalently and site-specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig light chain polypeptides, fGly-modified Ig light chain polypeptides, and antibody conjugates, as well as methods of use of same.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: December 28, 2021
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Yun Cheol Kim, Chao Bai Huang, David Rabuka
  • Patent number: 11167158
    Abstract: A method of custom manufacturing a flame arrestor includes providing a housing having an interior surface and an exterior surface where the exterior surface of the housing is shaped to fit within a fluid passageway. The method includes forming, using an additive manufacturing technique, a three-dimensional lattice structure by depositing a first material onto the interior surface of the housing in a predetermined pattern. The lattice structure includes a plurality of connected lattice members forming channels extending from a first end to a second end of the three-dimensional lattice structure. An element of a second material is provided adjacent to the three-dimensional lattice structure. The second material is different than the first material and the element is configured to draw heat away from fluid flowing through the plurality of channels.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: November 9, 2021
    Assignee: Emerson Process Management Regulator Technologies Tulsa, LLC
    Inventors: John D. Cockerham, James Myers
  • Patent number: 11099147
    Abstract: Disclosed are a gas sensor member, a gas sensor using the same, and manufacturing methods thereof, and specifically, a gas sensor member using a one-dimensional porous metal oxide nanotube composite material having a double average pore distribution in which mesopores (0.1 nm to 50 nm) and macropores (50 nm to 300 nm) are simultaneously formed on the surface of a nanotube through decomposition of a spherical polymer sacrificial template and continuous crystallization and diffusion of a metal oxide and a nanoparticle catalyst embedded in an apoferritin is uniformly loaded in the inside and on the outer wall and inner wall of a one-dimensional metal oxide nanotube through a high-temperature heat treatment, a gas sensor using the same, and manufacturing methods thereof are disclosed.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: August 24, 2021
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Il-Doo Kim, Ji Su Jang, Sang-Joon Kim, Seon-Jin Choi
  • Patent number: 11046753
    Abstract: A method for conjugating an isolated antibody to a label or derivatisation reagent, which method comprises contacting the antibody with an activated label or activated derivatisation reagent, or contacting the antibody with the label or derivatisation reagent in the presence of an antibody conjugation reagent, in a buffer system which comprises a monocarboxylic acid buffer compound other than glycine, bearing an amine substituent at the alpha or beta position.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 29, 2021
    Assignee: INNOVA BIOSCIENCES LTD.
    Inventors: Nicolas Steven Gee, Bianca Fusetti
  • Patent number: 10996181
    Abstract: Provided is a sensor comprising a non-conductive substrate; and a conductive layer electronically printed on one side of the substrate, wherein the conductive layer comprises: an antenna pattern for transmitting and receiving a radio signal with an external device; a sensing electrode connected to the antenna pattern via a circular wiring for sensing an impedance change due to contact with a sensing target material; and a coating electrode stacked on the sensing electrode for removing an occurrence of noise of the impedance change. Accordingly, the present invention solves the problem of a sensor, in the form of a terminal, not being compact and the problem of high manufacturing costs and low manufacturing quality of a sensor manufactured using a deposition method in order to replace such sensor with a sensor manufactured by a printing method, and solves a corrosion problem of a sensing electrode, a durability problem, etc. that may occur in the sensor of the printing method.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 4, 2021
    Assignee: LG ELECTRONICS INC.
    Inventors: Hyunchul Kim, Myungwon Lee
  • Patent number: 10995911
    Abstract: A pressure vessel for storing hydrogen is described. The pressure vessel includes at least one chamber to store hydrogen atoms. The pressure vessel also includes a mycelium structure within the at least one chamber. The mycelium structure has a surface area of at least 800 m2/m3. At least some of the hydrogen atoms are attached to the mycelium structure at a pressure greater than ambient pressure. Methods of storing hydrogen and methods of constructing a hydrogen storage tank are also described.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: May 4, 2021
    Assignee: The Boeing Company
    Inventors: Benjamin J. Stephenson, Jeffrey M. Hansen
  • Patent number: 10927419
    Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: February 23, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Christina Fan, Stephen P. A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
  • Patent number: 10927335
    Abstract: A microfluidic device includes a base comprising a chamber configured to receive a microfluidic component. A sealing member includes a body, an inlet reservoir, and an outlet reservoir, where the inlet reservoir and the outlet reservoir communicate with the chamber through fluid passages when the sealing member and base are removably coupled. A microfluidic component removably within the chamber includes microfluidic channels on a surface thereof and a tissue culture chamber coupled to at least one of the microfluidic channels. The microfluidic channels and the tissue culture chamber are in fluid communication with the inlet and outlet reservoirs through the fluid passages to form a fluid circuit for directing fluid from the inlet reservoir, through the tissue culture chamber, to the outlet reservoir, and from the outlet reservoir back to the inlet reservoir upon tilting the microfluidic device to a forward tilted position and to a reverse tilted position, respectively.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: February 23, 2021
    Assignee: Cornell University
    Inventor: Mandy Brigitte Esch
  • Patent number: 10875898
    Abstract: The present invention according to a first aspect relates to a Trichoderma longibrachiatum strain comprising an autologous nucleotide sequence coding for a protein having at least 70% sequence similarity with the amino acid sequence of SEQ ID NO: 1 and its use for the treatment of a plant. Further aspects of the invention relate to a protein derived from said strain, methods for producing the protein, the use of the protein for the treatment of a plant and compositions comprising a source of the protein of the invention. Yet Further aspects of the invention relate to seeds treated with a source of the protein and methods for growing plants incorporating the step of treating said plants with the composition of the invention.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 29, 2020
    Assignee: Koppert B.V.
    Inventors: Matteo Lorito, Michelina Ruocco, Francesco Vinale, Sheridan Lois Woo
  • Patent number: 10851333
    Abstract: A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: December 1, 2020
    Assignee: Techshot, Inc.
    Inventors: John C. Vellinger, Eugene Boland, Michael A. Kurk, Krystal Milliner, Nester Samuel Logan
  • Patent number: 10844425
    Abstract: Compositions, methods, kits, and uses are provided for detecting or quantifying an Human Parainfluenza virus 1 (HPIV-1), HPIV-2, HPIV-3, and/or HPIV-4 nucleic acid, e.g., using nucleic acid amplification and hybridization assays. In some embodiments, the compositions, methods, kits, and uses target the HN gene of HPIV-1, HPIV-2, and/or HPIV-3 and/or the NP gene of HPIV-4.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: November 24, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Mehrdad Majlessi, Pamela Douglass, Daniel Kolk
  • Patent number: 10828399
    Abstract: The present disclosure is directed to methods of printing 3-D structures using supramolecular gels, and the structures that result therefrom.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: November 10, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jason Alan Burdick, Chris Highley
  • Patent number: 10815139
    Abstract: A material for reducing the content of polluting and/or unwanted substances in a liquid includes at least one polymeric and/or inorganic base, suitable to be immersed in the liquid, having at least a surface, whereto is bonded at least one catalyst of the degradation reaction of inorganic salts in gaseous substances. The catalyst, whose function is to reduce the energy required for the activation of said reaction and to accelerate its progress, is an enzyme preferably selected among the lyase group, the hydrolase group and the oxidoreductase group.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: October 27, 2020
    Assignee: ARCHIMEDE R&D S.R.L.
    Inventor: Lucio Panizza
  • Patent number: 10654917
    Abstract: The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 19, 2020
    Assignee: TECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA
    Inventors: Sofia Volker Côrte-Real, Vera Luísa Santos Neves, Pedro Manuel Correia Canhão, Tiago Fleming Outeiro, Miguel Augusto Rico Botas Castanho, Frederico Nuno Castanheira Aires Da Silva, Soraia Rafaela Santiago De Oliveira
  • Patent number: 10626391
    Abstract: The invention provides granules comprising A) at least one enzyme selected from at least one of the groups selected from transferases of EC 2, hydrolases of EC 3, lyases of EC 4 and isomerases of EC 5, B) at least one polymer selected from C1-C10-alkyl acrylate polymer, C1-C10-alkyl methacrylate polymer and C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer, preferably C1-C10-alkyl acrylate-C1-C10-alkyl methacrylate copolymer and C) at least one inorganic carrier material.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: April 21, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Frank Hellmers, Thomas Hueller, Thomas Dassinger, Oliver Thum
  • Patent number: 10538443
    Abstract: The present invention relates to a method for degrading and inactivating at least one xenobiotic, the at least one xenobiotic being present in an aqueous medium. The method comprises the steps of (a) grafting at least one enzyme onto a solid support, (b) incubating the solid support with the at least one enzyme into the aqueous medium and (c) measuring the evolution of the concentration of the at least one xenobiotic. The method is remarkable in that the at least one enzyme is New-Dehli metallo-?-lactamase 1, a laccase extracted from Pleurotus ostreatus and/or a ?-lactamase extracted from Pseudomonas aeruginosa and in that the solid support is a moving bed carrier.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: January 21, 2020
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Sebastien Bonot, Henry-Michel Cauchie
  • Patent number: 10525163
    Abstract: This invention relates to methods of producing collagen biomaterials by admixing (i) a solution of monomeric collagen, (ii) a solution of polymeric collagen, (ii) cargo particles, and (iv) a non-collagen blocking polymer, to produce a collagen solution. The collagen solution is then allowed to solidify to produce a collagen hydrogel. This may be useful in improving the stiffness of collagen hydrogel constructs and increasing the entrapment and retention of cargo particles.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: January 7, 2020
    Inventor: Josephine Wong
  • Patent number: 10512696
    Abstract: The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: December 24, 2019
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Shiladitya Sengupta, Abhimanyu Paraskar, Shivani Soni, Sudipta Basu, Poulomi Sengupta
  • Patent number: 10508297
    Abstract: The present invention provides an insoluble enzymatic reagent for detecting products derived from glucuronide metabolites in a sample, containing an enzyme with glucuronidase activity immobilized on a resin comprising a polysaccharide modified with chemical groups, and optionally a cationic polymer. Additionally, it provides methods for preparing said enzymatic reagent and for detecting derivatives of glucuronide metabolites in a sample, using said reagent.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: December 17, 2019
    Assignee: LA PIEDRA BIOTECNOLOGÍA SPA
    Inventors: Manuel Rozas Andreu, Fernando Alexis Gutierrez Rojas, Rocio Andrea Peralta Villalobos
  • Patent number: 10479971
    Abstract: A culture container has a first inflow port and a first outflow port. The first flow path connects the first outflow port to the first inflow port. A storage container is provided within the first flow path and has a second inflow port which is connected to the first outflow port and a second outflow port which is connected to the first inflow port. A second flow path connects a first region within the first flow path, and a second region within the first flow path. A division processing portion is provided within the second flow path, performs a division process of dividing a cell aggregation flowing in from the first flow path, and allows the cells subjected to the division process to flow out into the first flow path via the second region. A medium supply portion supplies a medium to the inside of the first flow path.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: November 19, 2019
    Assignee: FUJIFILM CORPORATION
    Inventors: Hideaki Kagawa, Shun Goto, Souichi Kohashi, Hidekazu Yamazaki
  • Patent number: 10441610
    Abstract: Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: October 15, 2019
    Assignee: Georgia Tech Research Corporation
    Inventors: Barbara Dale Boyan, Zvi Schwartz, Christopher S. D. Lee, Shirae Kerisha Leslie, Ramsey C. Kinney
  • Patent number: 10436682
    Abstract: A Raman silent substrate includes a base and a biologically compatible material layer over the base. The biologically compatible material layer is Raman silent, provides a predetermined capture efficiency corresponding to a desired application, and supports biological culturing. In certain implementations, the base comprises a glass layer and an aluminum layer between the glass layer and the biologically compatible material layer.
    Type: Grant
    Filed: May 29, 2016
    Date of Patent: October 8, 2019
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Patent number: 10435676
    Abstract: The present invention relates to a variant of Terminal deoxynucleotidyl Transferase (TdT) which (i) comprises the amino acid sequence as set forth in SEQ ID Nº 2 or a functionally equivalent sequence, with at least an amino acid substitution at position corresponding to residue C302 or functionally equivalent residue, wherein the position is numbered by reference to the amino acid sequence set forth in SEQ ID Nº 1, (ii) is able to synthesize a nucleic acid fragment without template and (iii) is able to incorporate a modified nucleotide into the nucleic fragment.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: October 8, 2019
    Inventors: Elise Champion, Mikhael Soskine, Thomas Ybert, Marc Delarue
  • Patent number: 10429665
    Abstract: A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half-ring shape.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: October 1, 2019
    Assignee: Optical Biosystems, Inc.
    Inventors: Chun-Sheu Lee, Jong Buhm Park
  • Patent number: 10400275
    Abstract: The present invention relates to in situ hybridization methods for detecting a target nucleic acid in a biological sample comprising performing one or more method steps (e.g., pretreatment, denaturation, hybridization, washes) at room temperature. The invention further relates to kits for performing such methods.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: September 3, 2019
    Assignee: Cellay, Inc.
    Inventor: Joan Aurich-Costa
  • Patent number: 10281473
    Abstract: The application discloses compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8M urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin I, resulting in a product mixture containing 3-10 kDa peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (ETD) and collision activated dissociation mass spectrometry. This method provides 95% sequence coverage of a mAb and detects numerous post-translational modifications. For disulfide bond location, native mAb is subjected to longer digestion times. Release of disulfide containing peptides from accessible regions of the folded protein occurs with short digestion times.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: May 7, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: Donald F. Hunt, Weihan Wang, Lichao Zhang
  • Patent number: 10221354
    Abstract: A luminescent particle including a surface comprising glass that surrounds one or more particles of one or more light emissive materials is disclosed. Preferably the surface comprises a vitrified glass. Methods form making a luminescent particle including a surface comprising glass that surrounds one or more particles of one or more light emissive materials is also disclosed. Compositions and products including a luminescent particle are further disclosed.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: March 5, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Robert J. Nick
  • Patent number: 10202587
    Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: February 12, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
    Inventors: Eric Chabriere, Mikael Elias, Julien Hiblot, Didier Raoult