Triglyceride Splitting (e.g., Lipase, Etc. (3.1.1.3)) Patents (Class 435/198)
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Patent number: 8703463Abstract: The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.Type: GrantFiled: March 8, 2010Date of Patent: April 22, 2014Assignee: DSM IP Assets B.V.Inventors: Lucie Parenicova, Ronald Busink, Jan Metske Van Der Lann
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Patent number: 8679774Abstract: The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.Type: GrantFiled: August 4, 2010Date of Patent: March 25, 2014Assignee: Novozymes A/SInventors: Kirsten Bojsen, Allan Svendsen, Claus Crone Fuglsang, Shamkant Anant Patkar, Kim Borch, Jesper Vind, Andreas Petri, Sanne O. Schroder Glad, Gitte Budolfsen
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Patent number: 8679813Abstract: The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.Type: GrantFiled: April 19, 2010Date of Patent: March 25, 2014Assignee: Novozymes A/SInventors: Jesper Vind, Kim Borch, Mikael Mikkelsen, Jurgen Carsten Franz Knotzel
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Publication number: 20140075601Abstract: The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.Type: ApplicationFiled: October 28, 2013Publication date: March 13, 2014Applicant: NOVOZYMES A/SInventors: Carsten Andersen, Thomas Agersten Poulsen
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Publication number: 20140069866Abstract: A zinc compound and methods for use in removing phosphate from water. Preferably the compound is used in removing phosphate from water in swimming pools, spas, and similar structures. Several water treatment techniques are disclosed, as well as a variety of different methods for delivery of the active ingredients. These delivery methods include use of a slurry of the active reagent in solution as well as a tablet, powder, or granulated structure. Additionally, the water treatment techniques may incorporate the use of a combination including both enzymatic compositions and compounds for phosphate removal.Type: ApplicationFiled: November 15, 2013Publication date: March 13, 2014Applicant: Natural Chemistry L.P.Inventor: Richard Okun
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Publication number: 20140051119Abstract: The present invention provides fungal xylanase and/or beta-xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase and/or beta-xylosidases, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures.Type: ApplicationFiled: June 10, 2013Publication date: February 20, 2014Applicant: Codexis, Inc.Inventors: Ryan Fong, Xiyun Zhang, Chirs Noriega, Nicholas Agard, Anupam Gohel, Derek Smith
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Patent number: 8652824Abstract: Disclosed herein is an isolated nucleic acid molecule encoding a recombinant polypeptide that has pancreatic lipase activity. Also disclosed herein are a recombinant vector and a recombinant host cell for producing the recombinant polypeptide. The recombinant polypeptide is adapted for preparation of an animal feed that is able to facilitate utilization of fats therein by pigs (especially postweaning pigs) and to enhance growth performance of the pigs.Type: GrantFiled: February 16, 2011Date of Patent: February 18, 2014Assignee: Livestock Research Institute Council of AgricultureInventor: Fang-Chueh Liu
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Patent number: 8647848Abstract: The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.Type: GrantFiled: May 22, 2009Date of Patent: February 11, 2014Assignee: Evonik Goldschmidt GmbHInventors: Frank Hollmann, Oliver Thum, Christoph Toelle, Angelo Provinzano, Cornelis Gerrit Nijs Korevaar
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Publication number: 20140037790Abstract: The present invention is intended to provide a quality improving agent useful for improving the quality of steamed buns, and a quality improving agent containing glucoamylase. The quality improving agent preferably has low protease activity.Type: ApplicationFiled: February 20, 2012Publication date: February 6, 2014Applicant: AMANO ENZYME INC.Inventors: Qinglong Xu, Kimihiko Sato, Shotaro Yamaguchi
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Patent number: 8637278Abstract: The invention relates to a method for the enzymatic production of emulsifiers containing mono- and diacylglycerides. In a first step a), a mixture of a phospholipid component and a triacylglyceride component is prepared, then in step b) a quantity of an aqueous solution containing a (phospho)lipase is added to the mixture obtained, to produce a water content of the mixture of between 3 and 15 wt. %. In a subsequent step c), the mixture obtained in the previous step is reacted at a temperature ranging between 20° and 80° C. over a period of at least two hours and said mixture is then dried.Type: GrantFiled: September 2, 2004Date of Patent: January 28, 2014Assignee: Satia GmbHInventors: Michael Volland, Thomas Lötzbeyer, Volker Sieber, Eva Wittmann
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Patent number: 8637101Abstract: The present invention relates to novel polynucleotide sequences comprising genes that encode novel lipolytic enzymes, as well as functional equivalents of the gene or the amino acid sequences with high homology thereto. The invention also relates to methods of using these lipolytic enzymes in industrial processes, for example in the dairy or baking industry.Type: GrantFiled: February 26, 2009Date of Patent: January 28, 2014Assignee: DSM IP Assets B.V.Inventors: Jan Metske Laan Van Der, Yulia M. Efimova, Karin Turk, Margot Elisabeth Francoise Schooneveld-Bergmans, Arie Gerrit Terdu, Arjen Sein, Natalja Alekseevna Cyplenkova
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Publication number: 20140017733Abstract: The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. In some embodiments, the xylanase and xylosidase enzyme(s) are M. thermophila enzymes.Type: ApplicationFiled: June 10, 2013Publication date: January 16, 2014Inventors: Nicholas John Agard, David Elgart, Jie Yang, Goutami Banerjee, Jeanne Bonomo Benoit, Dipnath Baidyaroy
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Publication number: 20140011239Abstract: The present invention provides a method of increasing extracellular secretion of secretory proteins by co-expressing the secretory proteins with a mature cutinase. Cutinase can improve the permeability of E. coli cell membrane without destroying the membrane, and thus facilitate cross-membrane transfer of the secretory proteins co-expressed in E. coli. Increased extracellular secretion of target proteins can shorten cell culture time, reduce the formation of inclusion bodies and increase production of target proteins.Type: ApplicationFiled: July 4, 2013Publication date: January 9, 2014Inventors: Jing Wu, Lingqia Su, Jian Chen
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Patent number: 8617866Abstract: Disclosed is an enzymatic process for the preparation of fatty acid alkyl esters, particularly fatty acids methyl esters (biodiesel) in a solvent-free microaqueous system, from a fatty acid source and an alcohol or alcohol donor, employing a robust lipase preparation that comprises at least two lipases separately or jointly immobilized on a suitable support, where one of the lipases has increased affinity to partial glycerides, another is sn-1,3 positional specific, and an optional third lipase has high selectivity towards sn-2 position of the glycerol backbone of the fatty acid source.Type: GrantFiled: November 13, 2008Date of Patent: December 31, 2013Inventors: Sobhi Basheer, Maisa Haj, Muhammad Kaiyal
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Publication number: 20130337277Abstract: A liquid composition for producing a self-destructible temporary structure by additive manufacturing is provided. The liquid composition includes a biosynthetic copolymer as a degradable component and an enzyme as a disintegrating agent, the disintegrating agent is capable of disintegrating the degradable component, wherein after exposure to an external trigger, the disintegrating agent gradually degrades the degradable component.Type: ApplicationFiled: June 25, 2013Publication date: December 19, 2013Inventors: Daniel DIKOVSKY, Eduardo Napadensky
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Publication number: 20130330781Abstract: The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity, which perform very well in industrial applications such as laundry compositions, for biopolishing of newly manufactured textiles, for providing an abraded look of cellulosic fabric or garment, and for treatment of paper pulp. Further, the invention relates to DNA constructs encoding such enzymes, a method for providing a gene encoding for such enzymes, a method of producing the enzymes, enzyme preparations containing such enzymes, and the use of these enzymes for a number of industrial applications.Type: ApplicationFiled: November 21, 2012Publication date: December 12, 2013Applicant: NOVOZYMES A/SInventors: Martin Schulein, Lene Nonboe Andersen, Soren Flensted Lassen, Markus Sakari Kauppinen, Lene Lange, Ruby Ilum Nielsen, Shinobu Takagi, Michiko Ihara
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Publication number: 20130316408Abstract: The invention discloses marine Streptomyces sp., a Pyranosesquiterpene compound, as well as a preparation method and uses thereof. Streptomyces sp. SCSIO 01689 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011257 on Jul. 18, 2011. The Streptomyces sp. SCSIO 01689 can produce the Pyranosesquiterpene compound with better anti-Escherichia coli activity and anti-Artemia activity, as well as Cyclo(D)-Pro-(D)-Ile, Cyclo(D)-Pro-(D)-Leu and Cyclo(D)-trans-4-OH-Pro-(D)-Phe with better anti-Vibrio anguillarum activity and anti-Artemia activity, thereby providing a new way for preparing the Cyclo(D)-Pro-(D)-Ile, the Cyclo(D)-Pro-(D)-Leu and the Cyclo(D)-trans-4-OH-Pro-(D)-Phe. The Pyranosesquiterpene compound can be used for preparing anti-Escherichia coli medicaments and anti-Artemia medicaments, as well as preparing condiments as a condiment precursor compound.Type: ApplicationFiled: June 18, 2012Publication date: November 28, 2013Applicant: South China Sea Institute Of Oceanology, Chinese Academy of SciencesInventors: Lijuan Long, Xinpeng Tian, Jie Li, Xiongming Luo, Zhenxiong Qi, Tuan Yin
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Publication number: 20130309751Abstract: The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 9, 2011Publication date: November 21, 2013Applicant: Novozymes A/SInventors: Lan Tang, Ye Liu, Kim Borch, Jesper Brask
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Patent number: 8584892Abstract: A packet of an enzyme and/or enzyme producing bacteria is contained within the core of a roll of toilet tissue or similar paper product wound on a core. The packet has a cover that dissolves or disintegrates on contact with water and disperses its contents into the aqueous waste stream. The packet may contain a mixture of bacterial cultures that produce enzymes to attack the greasy or fatty components of the waste stream. An additional article such as a sample of a liquid or creme personal care product may also be contained within the tissue paper core.Type: GrantFiled: January 19, 2010Date of Patent: November 19, 2013Inventor: Joseph R. Lira
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Publication number: 20130302879Abstract: The present invention relates to the use of glycosyl hydrolase family (61) polypeptides in the presence of cellulases for textile manufacture as well as a textile composition comprising glycosyl hydrolase family (61) polypeptides and cellulases.Type: ApplicationFiled: December 14, 2011Publication date: November 14, 2013Applicant: Novozymes A/SInventors: Weijan Lai, Guifang Wu
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Patent number: 8580550Abstract: There is provided a lipase powder which is a granulated material comprising a lipase and at least one member selected from the group consisting of fatty acids having 8 to 12 carbon atoms, alcohol esters thereof, and a mixture thereof. This lipase powder has an increased lipase activity.Type: GrantFiled: March 12, 2007Date of Patent: November 12, 2013Assignee: The Nisshin OilliO Group, Ltd.Inventors: Tomomi Suganuma, Tadashiro Hirose, Junko Suzuki, Shin Arimoto, Hideaki Maki, Satoshi Negishi
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SECRETION YIELD OF A PROTEIN OF INTEREST BY IN VIVO PROTEOLYTIC PROCESSING OF A MULTIMERIC PRECURSOR
Publication number: 20130273606Abstract: The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The invention further relates to a cell comprising this nucleic acid molecule and a method for producing a protein of interest using this cell.Type: ApplicationFiled: April 18, 2013Publication date: October 17, 2013Inventors: Anna Cornelia Hendrika VAN HAUTUM, Arjo Lysander DE BOER, Jan Bastiaan BOUWSTRA, Peter Franciscus Theresius Maria VAN ASTEN -
Publication number: 20130273601Abstract: The present invention relates to a yeast cell comprising one or more exogenous genes of a pentose metabolic pathway non-native to the yeast cell wherein the yeast cell has a disruption of the hxk1, hxk2 glk1 and gal1 native in the yeast cell. The invention further relates to pentose and glucose fermenting yeast cell that is capable of simultaneous pentose and glucose consumption.Type: ApplicationFiled: October 11, 2011Publication date: October 17, 2013Applicant: DSM IP ASSETS B.V.Inventors: Hendrik Wouter Wisselink, Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk
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Publication number: 20130273611Abstract: Compositions and methods are provided for treating lignocellulosic material with a xylanase enzyme having xylanase activity. The enzyme is stable and active at increased pHs and temperatures. The present invention therefore provides methods for hydrolyzing lignocellulosic material, especially cellulose and hemicellulose, which are major components of the cell wall of non-woody and woody plants. The methods for hydrolyzing cellulose and hemicellulose can be used on any plant, wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct.Type: ApplicationFiled: September 8, 2011Publication date: October 17, 2013Applicant: SYNGENTA BIOTECHNOLOGY INC.Inventors: John Steffens, Paul Oeller, Yoshimi Barron
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Patent number: 8546112Abstract: The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.Type: GrantFiled: May 19, 2009Date of Patent: October 1, 2013Assignee: Sandoz AGInventors: Martin Albert, Ferdinand Zepeck, Andreas Berger, Waander Riethorst, Helmut Schwab, Daniel Luschnig, Peter Remler, Joerg Salchenegger, Doris Osl, Dominic De Souza
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Patent number: 8546114Abstract: The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.Type: GrantFiled: January 18, 2006Date of Patent: October 1, 2013Assignee: Chirogate International Inc.Inventors: Yu-Chih Yeh, Ming-Kun Hsu, Shih-Yi Wei
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Patent number: 8546115Abstract: The present invention relates to polyesterases having cutinase and/or suberinase activity obtainable from Coprinus and Trichoderma. The invention further relates to a method for producing the polyesterases, and to polynucleotides, vectors and host cells used therein. The enzymes are useful in hydrolysing cutin, suberin and other polyesters for example in treating agricultural or food raw materials, or wood raw materials, pulp and paper products and waste, and in modifying polyester fibers, or in laundry and dish applications.Type: GrantFiled: July 8, 2008Date of Patent: October 1, 2013Assignee: Valtion Teknillinen TutkimuskeskusInventors: Johanna Buchert, Tiina Nakari-Setälä, Pasi Halonen, Hanna Kontkanen, Ann Westerholm-Parvinen, Marjaana Rättö
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Publication number: 20130252850Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased.Type: ApplicationFiled: May 20, 2013Publication date: September 26, 2013Applicant: NOVOZYMES A/SInventors: Allan Svendsen, Soren Kjaerulff, Henrik Bisgaard-Frantzen, Carsten Andersen
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Patent number: 8541211Abstract: A method is disclosed for the generation of triacylglycerols from gums that have been separated from an oil product. The gums are treated with an enzyme having PLC activity, which results in the formation of diacylglycerols and phosphates, and treated with an enzyme having PLA activity, which results in the formation of lyso-phospholipids and free fatty acids. The diacylglycerols and the free fatty acids from these two separate reactions then combine in the presence of the enzymes to generate new triacylglycerol molecules.Type: GrantFiled: July 10, 2012Date of Patent: September 24, 2013Assignee: Bunge Oils, Inc.Inventor: Christopher L. G. Dayton
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Patent number: 8535900Abstract: The invention encompasses the use of a lipolytic enzyme obtainable from one of the following genera: Streptomyces, Corynebacterium and Thermobifida in various methods and uses, wherein the lipolytic enzyme hydrolyzes a glycolipid or a phospholipid or transfers an acyl group from a glycolipid or phospholipids to an acyl acceptor. The present invention also relates to a lipolytic enzyme that hydrolyzes at least a galactolipid or transfers an acyl group from a galactolipid to one or more acyl acceptor substrates, wherein the enzyme is obtainable from Corynebacterium species.Type: GrantFiled: February 1, 2010Date of Patent: September 17, 2013Assignee: Dupont Nutrition Biosciences APSInventors: Andrei Miasnikov, Jørn Borch Søe, Jørn Dalgaard Mikkelsen, Mira Povelainen, Virve Pitkanen
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Publication number: 20130236944Abstract: The invention relates to methods for inactivating antibiotics in the environment. The invention further relates to the use of a laccase, a lipase or a cellulase for inactivation of antibiotics. It also relates to compositions to decontaminate the polluted environment and to prevent the pollution of the environment by inactivating antibiotics from waste and wastewater effluents before they reach the environment.Type: ApplicationFiled: July 13, 2011Publication date: September 12, 2013Applicant: Da VolterraInventors: Claude Bensoussan, Jean De Gunzburg
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Patent number: 8530219Abstract: The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides compositions comprising this serine protease variant. In some embodiments, the present invention provides laundry and other non-automatic (i.e., hand) dishwashing cleaning compositions comprising this serine protease variant.Type: GrantFiled: November 10, 2009Date of Patent: September 10, 2013Assignee: Danisco US Inc.Inventors: David A. Estell, Frits Goedegebuur, Ayrookaran Poulose
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Patent number: 8524481Abstract: Provided in part herein are compositions that include isolated microbial enzymes, such as proteases, lipases, useful in dehairing leather. Also provided are methods for isolating proteases, lipases, from microbes, as well as methods of reusing these enzymes effectively for several cycles in an environment friendly process.Type: GrantFiled: November 16, 2010Date of Patent: September 3, 2013Assignee: West Bengal University of TechnologyInventor: Shaon Ray Chaudhuri
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Publication number: 20130224807Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.Type: ApplicationFiled: June 15, 2012Publication date: August 29, 2013Applicant: INVISTA North America S.a r.l.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes
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Publication number: 20130209436Abstract: The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.Type: ApplicationFiled: April 23, 2011Publication date: August 15, 2013Applicant: SYNAGEVA BIOPHARMA CORP.Inventors: Anthony Quinn, Alex J. Harvey
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Patent number: 8507241Abstract: The invention relates to a DNA sequence that encodes a polypeptide with lysophospholipase activity and was isolated from Aspergillus and sequences derived therefrom, polypeptides with lysophospholipase activity encoded by these sequences as well as the use of these polypeptides for improving the filterability of syrups consisting of wheat starch and for related applications.Type: GrantFiled: May 10, 2012Date of Patent: August 13, 2013Assignee: AB Enzymes GmbHInventors: Khanh Q. Nguyen, Volker Marschner, Kornelia Titze, Bruno Winter
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Publication number: 20130193070Abstract: A zinc compound and methods for use in removing phosphate from water. Preferably the compound is used in removing phosphate from water in swimming pools, spas, and similar structures. Several water treatment techniques are disclosed, as well as a variety of different methods for delivery of the active ingredients. These delivery methods include use of a slurry of the active reagent in solution as well as a tablet, powder, or granulated structure. Additionally, the water treatment techniques may incorporate the use of a combination including both enzymatic compositions and compounds for phosphate removal.Type: ApplicationFiled: January 18, 2013Publication date: August 1, 2013Applicant: Natural Chemistry L.P.Inventor: Natural Chemistry L.P.
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Publication number: 20130196411Abstract: The present invention relates to a newly identified lipase belonging to the Ustilaginaceae family of Basidomycetes and variants thereof. The invention also relates to polynucleotides encoding the lipase and the variants thereof. The invention further relates to procedures for producing the lipase, and variants thereof, polypeptides and polynucleotides. The invention further relates to lipase variants with an increased trans-selectivity. The invention further relates to lipase variants with a preference for long chain fatty acid esters or carboxylic acid moieties with a chain length greater than C12. The invention further relates to a method of reducing, or eliminating, trans-fatty acids from liquid oil stable enough for frying systems.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: FRITO-LAY TRADING COMPANY, GMBHInventor: FRITO-LAY TRADING COMPANY, GMBH
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Publication number: 20130195835Abstract: Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.Type: ApplicationFiled: September 14, 2012Publication date: August 1, 2013Applicants: OXYRANE UK LIMITED, UNIVERSITEIT GENT, VIB VZWInventors: Nico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
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Publication number: 20130196395Abstract: The present invention relates to a mini-emulsion which comprises at least one hydrolase, where the continuous phase of the mini-emulsion contains at least one oxidant, while the dispersed phase comprises at least one C6-60 carboxylic acid and optionally at least one reactant. Furthermore, the present invention relates to a method of preparing the mini-emulsion and to a process for the preparation of C6-60 percarboxylic acids and to a process for the preparation of an oxidized reactant, in each case using the abovementioned mini-emulsions.Type: ApplicationFiled: March 14, 2013Publication date: August 1, 2013Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V., HENKEL AG & CO., KGAAInventors: HENKEL AG & CO. KGAA, MAX-PLANCK-GESELLSCHAFT ZUR FORDERU DER WISSENSCHAFTEN E.V.
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Patent number: 8486390Abstract: A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using of a biomarker, the presence of chymotrypsin in the gastrointestinal tract to determine the presence of symptoms of addiction, and the likelihood of relapsing into addiction is disclosed.Type: GrantFiled: July 31, 2012Date of Patent: July 16, 2013Assignee: Curemark LLCInventor: Joan M. Fallon
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Publication number: 20130177947Abstract: The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.Type: ApplicationFiled: September 22, 2010Publication date: July 11, 2013Applicant: DANISCO US INC.Inventors: Benjamin Bower, Megan Yee Hsi, Thijs Kaper, Bradley R. Keleman, Suzanne E. Lantz, Edmund A. Larenas, Colin Mitchinson, Steven Kim, William D. Hitz, Mark Emptage, Keith Dumont Wing
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Publication number: 20130164818Abstract: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.Type: ApplicationFiled: December 6, 2011Publication date: June 27, 2013Applicant: XYLECO, INC.Inventor: Marshall Medoff
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Publication number: 20130156737Abstract: The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts.Type: ApplicationFiled: October 1, 2012Publication date: June 20, 2013Applicant: University of Washington through its Center for CommercializationInventor: University of Washington through its Center for
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Publication number: 20130157325Abstract: Molecular dynamics (MD) simulation on the three-dimensional structure of Candida anrtarctica lipase B revealed two hitherto unknown lids with a marked mobility, and this discovery was used to design lipolytic enzyme variants with increased lipolytic enzyme activity.Type: ApplicationFiled: February 7, 2013Publication date: June 20, 2013Applicant: NOVOZYMES A/SInventor: NOVOZYMES A/S
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Publication number: 20130152234Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicants: NOVOZYMES A/S, NOVOZYMES, INC.Inventors: Novozymes, Inc., Novozymes A/S
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Patent number: 8460905Abstract: A method for degumming an oil composition comprises the steps of (a) providing an oil composition containing a quantity of phospholipids, (b) contacting said oil composition simultaneously with one or more phospholipase A enzymes and one or more phospholipase C enzymes, under conditions sufficient for the enzymes to react with the phospholipids to create phospholipid reaction products, and (c) separating the phospholipids reaction products from the oil composition, the remaining oil composition after the separation being a degummed oil composition, whereby during step (b) the reaction of said one or more phospholipase A enzymes proceeds at a faster rate than it would in the absence of said one or more phospholipase C enzymes, and wherein the reaction of step (b) continues for a duration of less than about one hour.Type: GrantFiled: September 11, 2007Date of Patent: June 11, 2013Assignee: Bunge Oils, Inc.Inventors: Christopher L. G. Dayton, Erin Marie Rosswurm, Flavio da Silva Galhardo
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Patent number: 8455235Abstract: The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.Type: GrantFiled: December 2, 2008Date of Patent: June 4, 2013Assignees: Novozymes A/S, Solvay Pharmaceuticals, GmbHInventors: Allan Svendsen, Lars Beier, Signe Eskildsen Larsen, Thomas Lenhard, Tanja Maria Rosenkilde Kjaer, Peter Colin Gregory
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Publication number: 20130137595Abstract: A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person may be a high-risk subject. In one embodiment, a plasma sample from a person is obtained. The level of at least one protein listed in Table S3 in the plasma sample is measured. The level of at least one protein in the plasma sample is compared with the level in a normal or healthy subject. The lymphoma is diagnosed based upon the level of the at least one protein in the plasma sample in comparison to the normal or healthy level.Type: ApplicationFiled: November 30, 2012Publication date: May 30, 2013Applicant: BATTELLE MEMORIAL INSTITUTEInventor: BATTELLE MEMORIAL INSTITUTE
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Publication number: 20130137159Abstract: A substrate or coating is provided that includes a lipase with enzymatic activity toward a component of a fingerprint. Also provided is a process for facilitating the removal of fingerprints is provided wherein an inventive substrate or coating including a lipase is capable of enzymatically degrading of one or more components of the fingerprint to facilitate fingerprint removal from the substrate or said coating. Applying heat to the substrate or coating increases the rate of fingerprint removal.Type: ApplicationFiled: February 4, 2013Publication date: May 30, 2013Applicants: TOYOTA MOTOR CORPORATION, Regents of the University of Minnesota, Toyota Motor Engineering & Manufacturing North America, Inc.Inventors: Toyota Motor Corporation, Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota