Bacillus (e.g., B. Subtilis, B. Thuringiensis, Etc.) Patents (Class 435/252.5)
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Patent number: 8404474Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.Type: GrantFiled: June 28, 2010Date of Patent: March 26, 2013Assignee: Ajinomoto Co., Inc.Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
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Publication number: 20130071907Abstract: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal feeds.Type: ApplicationFiled: November 14, 2012Publication date: March 21, 2013Applicant: Chr. Hansen A/SInventor: Chr. Hansen A/S
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Publication number: 20130064927Abstract: The disclosure relates to enzyme producing Bacillus strains that provide benefits to animals and methods of using these strains. In one embodiment, the disclosure relates compositions comprising the enzyme producing Bacillus strains. In yet another embodiment, the disclosure relates to a feed for an animal comprising enzyme producing Bacillus strains.Type: ApplicationFiled: August 24, 2012Publication date: March 14, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Mari Ellen Davis, Justin Sawall, Anthony Neumann, Greg Siragusa, Luis Romero
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Publication number: 20130065293Abstract: The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched ?-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel ?-glucosyltransferase which forms the branched ?-glucan, processes for producing them, and their uses.Type: ApplicationFiled: November 1, 2012Publication date: March 14, 2013Applicant: Hayashibara Co., Ltd.Inventor: Hayashibara Co., Ltd.
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Patent number: 8383097Abstract: The present invention relates to bacteria cultures and composition comprising one or more cultures of the invention. The invention also relates to methods of washing or cleaning laundry or fabrics and surfaces as well as degrading waste material using a bacteria culture of the invention.Type: GrantFiled: August 3, 2007Date of Patent: February 26, 2013Assignee: Novozymes Biologicals, IncInventor: Michael Eric Frodyma
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Publication number: 20130045185Abstract: The disclosure relates to strains, compositions and methods for detoxifying a mycotoxin. In another embodiment, the disclosure relates to strains, compositions and methods for alleviating the gastrointestinal inflammatory response resulting from ingestion of mycotoxins. In one embodiment, the strains are Bacillus strains. In another embodiment, the strains are lactic acid bacteria.Type: ApplicationFiled: August 17, 2012Publication date: February 21, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Mari Ellen Davis, Joshua Rehberger, Kimberly Novak, Thomas G. Rehberger
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Patent number: 8377455Abstract: New Bacillus licheniformis strain named V9T14 that produces a new biosurfactant composition that is effective against colonization and/or bio film formation from bacteria. The new biosurfactant composition can be used in combination with biocides for preventing formation and/or for eradicating bacteria grown planktonically and/or as a biofilm, preferably on biotic and/or abiotic surfaces.Type: GrantFiled: November 25, 2009Date of Patent: February 19, 2013Assignees: PAN-ECO S.A., University Technologies International LPInventors: Howard Ceri, Raymond J Turner, Maria Giovanna Martinotti, Fabrizio Rivardo, Gianna Allegrone
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Patent number: 8372601Abstract: The disclosure of the present application provides polypeptide sequences and nucleotide sequences coding for the polypeptide sequences of proteins used in the production of APPA-containing peptides. In at least one embodiment of the present disclosure, an isolated nucleic acid is disclosed which comprises a nucleotide sequence encoding a polypeptide having a sequence identity of 60 percent or greater to an amino acid sequence selected from the group consisting of SEQ ID NOS: 2-13, and 15-23.Type: GrantFiled: January 21, 2011Date of Patent: February 12, 2013Assignee: University of Illinois at Urbana-ChampaignInventors: William W. Metcalf, Wilfred A. van der Donk, Junkal Zhang, Benjamin T. Circello, Svetlana A. Borisova
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Publication number: 20130031673Abstract: Compositions comprising microbiological strains and cultures and methods of use thereof are provided herein. Certain strains, cultures, and compositions thereof are useful for the control of head blight disease, for example, of various crop plants. Biological control compositions, and methods of use thereof to prevent, inhibit or treat the development of plant pathogens or disease and for preserving plant yield, are also provided.Type: ApplicationFiled: July 24, 2012Publication date: January 31, 2013Inventors: Christopher J. Grandlic, Wayne A. Green, Janne S. Kenovuo, Ryan McCann
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Patent number: 8361762Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.Type: GrantFiled: September 15, 2009Date of Patent: January 29, 2013Assignees: Danisco US Inc., The Goodyear Tire & Rubber CompanyInventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Dmitrii V. Vaviline, Alex T. Nielsen
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Patent number: 8349337Abstract: The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a cholesterol-reducing agent for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.Type: GrantFiled: May 29, 2007Date of Patent: January 8, 2013Assignee: Ganeden Biotech, Inc.Inventors: Sean Farmer, Andrew R. Lefkowitz
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Publication number: 20120328572Abstract: Disclosed herein are microbiocidal compositions that include spore-forming strains of Bacillus. The compositions may be utilized to treat or prevent disease in aquatic animals such as farmed fish or crustaceans.Type: ApplicationFiled: April 30, 2012Publication date: December 27, 2012Applicant: AUBURN UNIVERSITYInventors: Jeffery Terhune, Mark Liles, Joseph Kloepper
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Publication number: 20120331589Abstract: The subject invention includes methods and plants for controlling lepidopteran insects, said plants comprising Cry1Fa and Cry1Da core toxin containing proteins in combination to delay or prevent development of resistance by the insect(s).Type: ApplicationFiled: December 16, 2010Publication date: December 27, 2012Applicant: DOW AGROSCIENCES LLCInventors: Thomas Meade, Kenneth Narva, Nicholas P. Storer, Joel J. Sheets, Aaron T. Woosley, Stephanie L. Burton
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Publication number: 20120329138Abstract: A process for separation of a mixture containing a microbial substance and a liquid using deformable filter is provided.Type: ApplicationFiled: December 19, 2011Publication date: December 27, 2012Applicant: SHELL OIL COMPANYInventors: Henry Van Kaathoven, Johannes Pieter Haan, Wilhelmus Maria Bond, Johannes Leendert Willem Cornelis Den Boestert
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Patent number: 8338160Abstract: A novel bacterial strain of Bacillus thuringiensis for inhibiting insect pests is provided, wherein the Bacillus thuringiensis includes the fragments of cry1Aa, a cry1Ab, a cry1C, a cry1D and a cry1F genes.Type: GrantFiled: December 29, 2008Date of Patent: December 25, 2012Assignee: Taiwan Agricultural Chemicals and Toxic Substances Research Inst., Council of AgricultureInventors: Ching-Chou Tzeng, Suey-Sheng Kao
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Patent number: 8329446Abstract: The present invention provides a biocontrol agent for the prevention and/or reduction of mold during mushroom production. In particular, the invention utilizes Bacillus spp. as an agent for the control of mold caused by Trichoderma spp. The Bacillus spp. is a biologically pure culture of Bacillus subtilis strain J-P13.Type: GrantFiled: February 26, 2008Date of Patent: December 11, 2012Assignee: Monaghan Mushrooms Ltd.Inventors: Nader Gheshlaghi, Jack Verdellen
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Publication number: 20120295335Abstract: A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth. The inhibitory nutritional component in the growth medium prevents back growth of cells from the bioreactor into the feed line(s). The growth medium with inhibitory nutritional component is diluted in the bioreactor.Type: ApplicationFiled: November 16, 2011Publication date: November 22, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventor: Scott Christopher Jackson
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Publication number: 20120295334Abstract: An improved fermentation device and method uses a combination of substantially pure Oxygen as the Oxygenation gas and a separate air (or other Oxygen reducing gas) purge through the headspace of a fermentation device. The air injection and air purge vent line are configured to maintain a backpressure within the headspace. The air purge permits improved oxygen utilization and increases safety through dilution and removal of ammonia gas emitted during fermentation.Type: ApplicationFiled: May 19, 2011Publication date: November 22, 2012Applicant: AIR LIQUIDE INDUSTRIAL U.S. LPInventor: Sudhir R. Brahmbhatt
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Patent number: 8304225Abstract: A novel bacterial strain of Bacillus thuringiensis for inhibiting insect pests is provided, wherein the Bacillus thuringiensis includes the gene fragments of cry1Ab, cry1Ac, cry1D, and cry1E.Type: GrantFiled: September 22, 2009Date of Patent: November 6, 2012Assignee: Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Council of AgricultureInventors: Ching-Chou Tzeng, Sheueh Kuo, Suey-Sheng Kao
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Patent number: 8273346Abstract: The invention relates generally to digestive disorders, and in particular to methods for treating irritable bowel syndrome by increasing carbohydrate absorption by administering a composition containing a Bacillus coagulans bacterium.Type: GrantFiled: February 4, 2009Date of Patent: September 25, 2012Assignee: Ganeden Biotech, Inc.Inventors: Sean Farmer, Andrew Lefkowitz
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Patent number: 8268608Abstract: The present invention provides a method of treating biomass that reduces water-polluting substances, suppresses the production of malodorous gases and greenhouse gases, decreases the nitrogen content in the compost or livestock bedding thus prepared, and furthermore, easily treats nitrogen-containing biomass in a short time at high temperature. The present invention also provides compost and livestock bedding produced by the method and a biomass treating agent. The method of treating biomass includes blending, with nitrogen-containing biomass, a Geobacillus microorganism having denitrification capability and a fermentation promoter that promotes the fermentation of the nitrogen-containing biomass by the Geobacillus microorganism.Type: GrantFiled: March 30, 2007Date of Patent: September 18, 2012Assignees: Menicon Co., Ltd., Toyota Jidosha Kabushiki KaishaInventors: Yutaka Matano, Ikuko Sugiyama, Shiori Emoto, Chikako Nakamura, Ikuo Fukumura, Masashi Takahashi
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Publication number: 20120230965Abstract: The present invention relates to a novel microorganism producing L-type poly-gamma-glutamic acid and an L-type poly-gamma-glutamic acid produced thereby and, more particularly, to Bacillus megaterium Toha (KCTC11752BP) isolated from salt-fermented Toha shrimps (Korean traditional fermented food) and an L-type poly-gamma-glutamic acid produced thereby. The novel microorganism Bacillus megaterium Toha (KCTC11752BP) has the ability to produce L-type poly-gamma-glutamic acid which can be used in high-value-added microbial agents, probiotic agents, immune-activating agents, animal drugs, cosmetics, moisture absorbers, thickeners, biodegradable plastics, etc.Type: ApplicationFiled: December 7, 2011Publication date: September 13, 2012Applicants: BIOLEADERS CORPORATION, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Moon-Hee SUNG, Chul Joong KIM, Haryoung POO, Mi-Sun KWAK, Sung-Bin PARK, Dong-Hwan CHOI, Ji Yeon KIM
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Publication number: 20120231951Abstract: The present invention relates to novel strains of Bacillus and methods of their use for enhancing the growth, promoting plant health or controlling diseases or pests of a plant.Type: ApplicationFiled: December 19, 2011Publication date: September 13, 2012Inventors: Magalie GUILHABERT-GOYA, Sarah F. HOVINGA, Daniel M. JOO, Jonathan S. MARGOLIS, Sarah J. MILLS, Varghese THOMAS, Damian CURTIS, Reed NATE ROYALTY, Roy WHITSON
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Publication number: 20120214221Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Applicants: Novozymes, Inc., Novozymes A/SInventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
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Patent number: 8246965Abstract: Bacillus isolates and compositions comprising the same are provided. Also provided are methods of inducing systemic acquired resistance to infection in a plant by applying a composition comprising a Bacillus control agent to said plant wherein said plant is capable of producing defense proteins.Type: GrantFiled: August 5, 2011Date of Patent: August 21, 2012Assignee: Montana State UniversityInventors: Barry Jacobsen, Nina K. Zidack, Rebecca Larson
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Publication number: 20120208230Abstract: The present invention relates to an EM-lacquer water solution mixed with a natural component, a method for preparing a fermented anti-oxidant material using the same, and a method for processing the material. Particularly, the EM-lacquer water solution mixed with a natural component is prepared by mixing an EM-lacquer solution, which is a mixture of a crude solution of effective micro-organisms (EM) 20˜35 weight percent and a lacquer water solution 65˜80 weight percent, and at least one natural component selected from a group comprising of organic brown sugar, bay salt, mandarin orange oil, Japanese apricot concentrate, Opuntia humifusa powder, dried orange peel powder, green tea powder, sea tangle powder, rice bran, camellia oil and bean powder, on the basis of the EM-lacquer water solution 20 L. Therefore, it can be used for daily life, industry, environmental purification and the like because it is made of non-toxic materials.Type: ApplicationFiled: February 13, 2012Publication date: August 16, 2012Inventor: Jeong Wan Ha
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Patent number: 8236549Abstract: The present disclosure relates to a strain of Bacillus amyloliquefaciens bacteria that hyperproduces amylase enzyme and protease enzyme. The strain is also suitable for producing lipase for the degradation of oleaginous materials such as fats, greases and cooking oils. The strain also has excellent fungicidal and/or fungistatic qualities. The strain of the present disclosure and the enzymes produced thereby have a number of applications, including agricultural uses, laundry and dish detergents, drain cleaners and spot removers, and among other things, baking applications.Type: GrantFiled: May 3, 2011Date of Patent: August 7, 2012Assignee: Novozymes Biologicals, Inc.Inventors: Yaowei Kang, Shawn Semones, Jessica Smith, Michael Frodyma
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Patent number: 8227235Abstract: Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.Type: GrantFiled: September 21, 2009Date of Patent: July 24, 2012Assignee: Alpharma, LLCInventors: James Skinner, Doug Rupp
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Publication number: 20120178143Abstract: The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the hydrolase of the present invention.Type: ApplicationFiled: January 16, 2012Publication date: July 12, 2012Applicant: DANISCO US INC.Inventor: David A. Estell
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Patent number: 8206966Abstract: Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.Type: GrantFiled: November 3, 2008Date of Patent: June 26, 2012Assignee: Danisco US Inc.Inventors: Luis G. Cascāo-Pereira, James T. Kellis, Jr., Bradley A. Paulson, Scott D. Power, Sandra W. Ramer, Vivek Sharma, Andrew Shaw, Jayarama K. Shetty, Donald E. Ward
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Publication number: 20120156759Abstract: A method for the biological decomposition of organic compounds of the group of hydrocarbons, fats, oils, waxes, and derivatives thereof as well as mixtures thereof in media polluted therewith, in the presence of at least one dispersant, wherein the medium polluted with the pollutants is treated with at least one dispersant and with microorganisms.Type: ApplicationFiled: June 15, 2010Publication date: June 21, 2012Applicants: TOTAL RAFFINAGE & MARKETING, GEORG FRITZMEIER GMBH & CO. KGInventors: Ursula Fritzmeier, Robert Mallee, Achim Wiessler
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Patent number: 8192977Abstract: This invention relates to ethanol production as a product of bacterial fermentation.Type: GrantFiled: November 12, 2009Date of Patent: June 5, 2012Assignee: Elsworth Biotechnology LimitedInventors: Edward Green, Muhammad Javed, Namdar Baghaei-Yazdi
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Publication number: 20120128827Abstract: The present product (“invention”) corresponds to a new strain of Bacillus subtilis NRRLB-50213 which produces secondary metabolites, bioactive substances and biodegrading enzymes. This strain of bacteria and/or its derivatives has/have the capacity to form functional feeds with high starch and/or soy flour content, as well as inhibiting the growth of pathogenic microorganisms. Functional feeds formulated with the NRRLB-50213 strain and high concentrations of vegetable flours have the capacity to generate growth, weight gain and survival equal to or greater than those generated by feeds which contain high fish flour or other animal protein content. Included in this invention are methods and formulas which increase growth, weight gain and survival percentage, since the decomposition and assimilation of formulated functional nutrients based on vegetable flour and the NRRLB-50213 strain of Bacillus subtilis are improved and maximized.Type: ApplicationFiled: November 18, 2011Publication date: May 24, 2012Applicant: CENTRO DE INNOVACION BIOTECHOLOGIVA, A.C.Inventor: JOSÉ LEONEL OCHOA
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Publication number: 20120124898Abstract: This invention provides co-cultures of photosynthetic microorganisms and biofuel producing microorganisms. In certain embodiments, polysaccharide-producing, photosynthetic microorganisms are microalgae having frustules provide a substrate on which biofuel-producing microorganisms can grow. In other embodiments, the photosynthetic microorganisms produce a lipid and the non-photosynthetic microorganisms produce a solvent in which the lipid is soluble.Type: ApplicationFiled: July 21, 2011Publication date: May 24, 2012Inventor: Pamela R. Contag
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Patent number: 8178325Abstract: There is provided is a process for producing a sulfur-containing ?-hydroxycarboxylic acid compound represented by the formula (2): wherein R1 represents hydrogen, C1-8 alkyl, or C6-20 aryl, which comprises subjecting a sulfur-containing ketol represented by the formula (1): wherein R1 is the same as defined above, to the action of microbial cells of a microorganism belonging to the genus Pseudomonas, Rhodococcus or Bacillus capable of converting the ketol into a corresponding ?-hydroxycarboxylic acid compound, or a treated material thereof, thereby producing the sulfur-containing ?-hydroxycarboxylic acid without using a hydroxynitrile compound as a starting material.Type: GrantFiled: September 21, 2007Date of Patent: May 15, 2012Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroyuki Asako, Koji Hagiya
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Publication number: 20120100589Abstract: A method for treatment of a material comprising lignocellulosic fibres is disclosed. More particularly, the treatment increases the accessibility of the lignocellulosic fibres for following microbial or biological processes.Type: ApplicationFiled: March 8, 2010Publication date: April 26, 2012Applicants: XERGI A/S, NOVOZYMES A/SInventors: Danielle Rhine, Anders Peter Jensen, Stefan Borre-Gude
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Publication number: 20120100094Abstract: The invention provides methods for providing Bacillus spores for application to agricultural soil or plant material as well as zootechnic applications for odor control in areas of high ammonia generation. The methods comprise suspending the Bacillus spores in a liquid consisting essentially of water and an organic acid, including acetic acid, wherein the acid lowers the pH so that the spores are inhibited from germination and growth; and so that growth of unwanted microorganisms in the suspension is prevented. Compositions formed according to the methods of the invention are also provided.Type: ApplicationFiled: October 20, 2010Publication date: April 26, 2012Applicant: Osprey Biotechnics, Inc.Inventors: Christopher J. Reuter, Steven J. MacKenzie
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Patent number: 8158402Abstract: A high-yield bacterial strain for producing acetoin named Bacillus pumilus XH195 has been deposited in a microorganism deposit center in Germany. The deposit number is DSM 16187. The bacteria of the strain are rod-shaped, 1.5 ?m to 3.0 ?m in length, and 0.6 ?m to 0.7 ?m in diameter. The colony color of the bacterial strain is yellow or white. The strain has the typical fatty acid profile of Bacillus and its physiological and biochemical characteristics align with those of Bacillus pumilus. When the bacteria of strain were cultured at 37° C. for 60 hours with shaking, the yield of acetoin could reach 63.0 g/L or 58.1 g/L, when glucose or sucrose was used as the substrate, respectively.Type: GrantFiled: November 4, 2005Date of Patent: April 17, 2012Assignee: Shanghai Apple Flavor & Fragrance Co., Ltd.Inventors: Ping Xu, Zijun Xiao, Yi Du, Zhonghao Wei
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Patent number: 8148138Abstract: A seed treated with a fungal/bacterial antagonist combination and a seed assembly comprising a seed and a fungal/bacterial antagonist combination. The fungal/bacterial antagonist combination comprises a Trichoderma virens fungal antagonist and a Bacillus amyloliquefaciens bacterial antagonist for controlling plant pathogens as a biocontrol agent, bio-pesticide or bio-fungicide. In preferred embodiments, the invention produces an increase in plant yield. Control of early and late season stalk and root rot caused by fungi such as Fusarium, Phythium, Phytophthora and Penicillium in tomatoes, peppers, turf grass, soybeans, sunflower, wheat and corn is achieved.Type: GrantFiled: August 16, 2008Date of Patent: April 3, 2012Inventor: Thomas D. Johnson
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Publication number: 20120076765Abstract: Six bacterial strains: Bacillus simplex strain 03WN13, Bacillus simplex strain 03WN23, Bacillus simplex strain 03WN25, Pseudomonas koreensis strain 10IL21, Pantoea agglomerans strain 10IL31, and Pseudomonas lini strain 13IL01, are superior antagonists of Phytophthora erythroseptica Pethybr., the causative agent of pink rot on potatoes. These bacterial strains are effective for suppression and control of pink rot on potatoes.Type: ApplicationFiled: September 24, 2010Publication date: March 29, 2012Inventors: David A. Schisler, Patricia J. Slininger, Tugba Adiyaman
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Publication number: 20120077181Abstract: The cryopreservation of cells and tissue cultures for long term storage of cells, cell constructs or three-dimensional complex tissues assemblies is based on the use of a collagen cell carrier (CCC) having a specific composition and thickness and appropriate mechanical properties which are maintained after thawing. The collagen cell carrier provides a suitable support for the cryopreservation resulting in high survival rates after thawing and providing cells and tissue assemblies already adhered to a mechanically stable and biocompatible support. Frozen collagen carrier-cells assemblies, the frozen artificial cell constructs or three-dimensional complex tissue assemblies obtainable by the method and the use thereof after thawing are also disclosed.Type: ApplicationFiled: February 18, 2010Publication date: March 29, 2012Inventors: Timo Schmidt, Lothar Just, Franz Maser, Holger Becker
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Publication number: 20120058531Abstract: The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a microorganism on a culture medium with high glycerine content. The invention also concerns a new microorganism, or strain of microorganism, adapted for the production of 1,3-propanediol from medium comprising high glycerine content. The invention also concerns an “adapted microorganism” which glycerol metabolism is directed to 1,3-propanediol production, and which is allowed to grow in the presence of a high concentration of industrial glycerine. The invention also concerns a biosourced 1,3-propanediol obtained by the process thereof. Finally the invention concerns the use of the above described biosourced 1,3-propanediol as extender chain in thermoplastic polyurethane, as monomers in polytrimethylene terephtalate and as a component in cosmetics formulations.Type: ApplicationFiled: May 5, 2010Publication date: March 8, 2012Applicant: METABOLIC EXPLORERInventors: Michel Chateau, Jean-Yves Dubois, Philippe Soucaille
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Patent number: 8124387Abstract: The invention relates to a process for the production of optically active Citronellal by enzymatic reduction of Citral with a reductase from Zymomonas mobilis.Type: GrantFiled: November 10, 2006Date of Patent: February 28, 2012Assignee: BASF SEInventors: Rainer Stuermer, Thomas Friedrich, Andre Mueller, Bernhard Hauer, Bettina Rosche
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Publication number: 20120045475Abstract: The present invention relates to a bacterium attenuated by a mutation in at least one ABC transporter gene wherein the mutation renders the corresponding ABC transporter protein non-functional and wherein the attenuated bacterium persists in a subject.Type: ApplicationFiled: February 17, 2010Publication date: February 23, 2012Applicant: AUSTRALIAN POULTRY CRC PTY LIMITEDInventors: Glenn Francis Browning, Philip Francis Markham, Chi-Wen Tseng
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Patent number: 8114648Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.Type: GrantFiled: October 26, 2007Date of Patent: February 14, 2012Assignees: The Scripps Research Institute, The Regents of the University of CaliforniaInventors: Peter G. Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
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Publication number: 20120028801Abstract: Aspects of the invention relate to organic biostimulant compositions, including, for example, formulations comprising corn steep liquor (CSL) and water. In certain illustrative embodiments, the organic biostimulant composition further comprises from one to five microbial strains as an inoculant. Another aspect of the invention relates to a method of cultivating plants that comprises the steps of preparing an organic biostimulant composition comprising water and CSL, and applying the organic biostimulant composition through a delivery system to a growth medium supporting plants.Type: ApplicationFiled: July 30, 2010Publication date: February 2, 2012Inventor: Ralph S. Daniels
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Publication number: 20120024795Abstract: A biosorbent for removing cationic and/or anionic metals from aqueous solutions, and a process for the production of the biosorbent. The biosorbent includes bacterial aggregates of Bacillus sp. VCHB-10, deposited as NRRL-B-30881, and treated with polyethyleneimine and glutaraldehyde. Among the metals in their cationic form, the following are considered: cations of Ag, Al, Au, Co, Cd, Cu, Cr, Fe, Hg, Mn, Ni, Pb, Pd, Pt, U, Th and Zn. Among the metals in their anionic form, the following are considered: anions of As, Cr and Mo. Removal or recovery of metals from wastewater using the biosorbent is also described.Type: ApplicationFiled: May 11, 2011Publication date: February 2, 2012Applicants: BIOTECNOLOGIA DEL AGUA LTDA., UNIVERSIDAD DE CHILEInventors: Davor Cotoras Tadic, Pabla Viedma, Juan Manuel Gajardo Sandoval
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Patent number: 8105592Abstract: The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.Type: GrantFiled: November 3, 2005Date of Patent: January 31, 2012Assignee: VHsquared LimitedInventors: Leo Gerardus Joseph Frenken, Lars-Gõran Lennart Hammarström, Adrianus Marinus Ledeboer
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Publication number: 20120021004Abstract: A new strain of Bacillus anthracis derived from the Sterne vaccine strain of Bacillus anthracis by growth on a high-nitrate-concentration, 3-amino-L-tyrosine growth medium.Type: ApplicationFiled: May 25, 2007Publication date: January 26, 2012Inventors: Jill E. Parker, Johnathan L. Kiel, Homer Gifford, John L. Alls, Pedro J. Morales
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Publication number: 20120015404Abstract: The invention belongs to the technical field of genetic engineering of agricultural microorganisms. Specifically, the invention relates to producing and using gene cluster for thuringiensin synthesis from Bacillus thuringiensis. The gene cluster includes 11 genes of thuA, thuB, thuC, thuD, thuE, thuF, thuG, thu1, thu2, thu3 and thu4. These genes have the nucleotide sequence as shown in SEQ ID NO: 1. And the thuringiensin biosynthetase encoded by these genes have the amino acid sequences as shown in SEQ ID NO: 2-12. The genes according to the invention and the proteins encoded by those genes can be used as new nucleosides lead compound of pesticide library and provide new target for developing insecticides. In practical use, a series of new, efficient and low toxic insecticide can be obtained by structure modification.Type: ApplicationFiled: December 15, 2009Publication date: January 19, 2012Applicant: HUAZHONG AGRICULTURAL UNIVERSITYInventors: Ming Sun, Ziniu Yu, Lifang Ruan, Shouwen Chen, Xiaoyan Liu, Donghai Peng