Lactobacillus, Pediococcus, Or Leuconostoc Patents (Class 435/252.9)
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Patent number: 8455226Abstract: This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising at least 4 mM of a silver or gold salt. A resulting nanosilver-containing composition is useful as a highly efficient antimicrobial agent, for instance when impregnated onto a carrier, or an algicide agent or a herbicide agent.Type: GrantFiled: July 5, 2007Date of Patent: June 4, 2013Assignee: Janssen Pharmaceutica N.V.Inventors: Wim De Windt, Tom Vercauteren, Willy Verstraete
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Patent number: 8454950Abstract: The use of docosahexaenoic acid in the manufacture of a composition for administration to a pregnant woman for reducing the risk of development of overweight or obesity of the baby in infancy and/or early childhood.Type: GrantFiled: October 7, 2011Date of Patent: June 4, 2013Assignee: Nestec S.A.Inventors: Ferdinand Haschke, Zdenek Kratky
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Patent number: 8449878Abstract: Naturally occurring lecithins and/or oleic acid stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products. They can be used in naturally occurring form, or where they are to be combined with probiotics in a carrier, or they can be treated to yield a stable powdered form of these naturally oily compounds. They can be sold as combined prebiotic/probiotic formulations in the same carrier, or sold as separate dietary supplements, e.g., in capsule or tablet form, to be used with the probiotic formulation as desired.Type: GrantFiled: May 31, 2011Date of Patent: May 28, 2013Assignee: Master Supplements, Inc.Inventors: Sonja Lea Yonak, Randolph S. Porubcan
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Patent number: 8444967Abstract: A method is described to treat diarrhea, vaginal yeast infections, constipation, heartburn, bloating, indigestion, flatulence or poor nutrient absorption, by administering a formulation of naturally occurring lecithins and/or oleic acid that stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products, and a formulation of Lactobacillus and Bifidobacterium species of probiotic bacteria. The formulations are in can a stable powdered form.Type: GrantFiled: May 30, 2011Date of Patent: May 21, 2013Assignee: Master Supplements, Inc.Inventors: Sonja Lea Yonak, Randolph S. Porubcan
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Patent number: 8445226Abstract: Processes to produce microorganisms that can be incorporated into a microbial-based product that results in high viable cell yields and shelf-stable products are disclosed. These microbial-based products are useful for inhibiting pathogenic growth and as a food additive. A preferred microorganism is a lactic acid producing bacteria. In one embodiment, the process comprises inoculating a lactobacillus fermentation medium with lactic acid producing bacterial cells, harvesting the lactic acid producing bacterial cells at mid to late log phase, concentrating the lactic acid producing bacterial cells, and preserving the lactic acid producing bacterial cells at a concentration of at least 5×109 cfu/ml.Type: GrantFiled: December 22, 2010Date of Patent: May 21, 2013Assignee: Microbios, Inc.Inventors: Matthew Ryan Garner, Joseph Flint
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Publication number: 20130121932Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.Type: ApplicationFiled: November 5, 2012Publication date: May 16, 2013Inventors: Bo Mollstam, Eamonn Connolly
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Publication number: 20130121977Abstract: Isolated strains of Lactobacillus plantarum are described that have anti-fungal activity against fungal spore suspensions, and specifically anti-fungal activity in fruit juices and fermented dairy products. The two species have also been found to have a high degree of heat tolerance and osmotolerance, and to have a high freeze-drying survival rate.Type: ApplicationFiled: November 14, 2012Publication date: May 16, 2013Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORKInventor: UNIVERSITY COLLEGE CORK, NATIONAL UNIV
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Patent number: 8440426Abstract: Disclosed is a method for producing an antimutagenic substance by using a lactic acid bacteria, which can produce the antimutagenic substance in a large quantity in an extremely simple manner and is economically advantageous; particularly a method for producing an antimutagenic substance effective for a carcinogenic substance, particularly a heterocyclic amine (HCA) which is a carcinogenic substance derived from a food, by using a lactic acid bacteria. Specifically disclosed is a method for producing an antimutagenic substance by using a lactic acid bacteria, which is characterized by suspending the lactic acid bacteria in a poorly nutrient or nutrient-free medium and leaving the lactic acid bacteria in the medium.Type: GrantFiled: April 18, 2008Date of Patent: May 14, 2013Assignee: Kigen Biogenics Institute Co., Ltd.Inventors: Minoru Fujita, Masaharu Nakayama, Yasuteru Nakamura, Takahiro Inoue
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Patent number: 8440178Abstract: The present invention generally relates to the field of obesity. In particular the present invention relates to the use of probiotics to treat obesity. One embedment of the present invention relates to the use of Lactobacillus rhamnosus CGMCC 1.3724 and/or Lactobacillus rhamnosus NCC 4007 for the preparation of a composition to support weight management, promote weight loss and/or to treat obesity.Type: GrantFiled: July 24, 2008Date of Patent: May 14, 2013Assignee: Nestec S.A.Inventors: Christian Darimont, David Philippe, Catherine Mace, Fabrizio Arigoni
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Patent number: 8440179Abstract: Provide a visceral fat reducing agent for reducing the diseases and conditions associated with the metabolic syndrome which represents a condition where various risk factors such as those for hypertension, hyperlipemia, glucose tolerance dysfunction, etc., have accumulated, or simply reducing an accumulation of visceral fat, wherein the effective ingredient of said visceral fat reducing agent includes fungus bodies of lactic bacteria, especially lactic bacteria belonging to the Lactobacillus sp. and Lactococcus sp. and/or cultures thereof, while also providing a beverage, food or feed containing said visceral fat reducing agent.Type: GrantFiled: February 29, 2008Date of Patent: May 14, 2013Assignee: Megmilk Snow Brand Co., Ltd.Inventors: Hiroshi Kawakami, Yasuhiko Shiinoki, Yukio Kadooka
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Publication number: 20130101566Abstract: The present disclosure is directed to compositions comprising Lactobacillus plantarum CECT 7484, Lactobacillus plantarum CECT 7485, and Pediococcus acidilactici CECT 7483 or a mutant or variant thereof. This composition is useful in the treatment of gastrointestinal diseases or conditions such as Inflammatory Bowel Disease, Irritable Bowel Syndrome, or abdominal distension and bloating.Type: ApplicationFiled: January 27, 2011Publication date: April 25, 2013Inventors: Jordi Espadaler Mazo, Jordi Cuñé Castellana
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Publication number: 20130101560Abstract: The present invention relates to use of the ABO blood group genotype of an individual as a criterion for microbiota modulation that is tailored based on the differences in the spectrum of bacteria found between individuals with different ABO blood group genotypes. The present invention relates further to a microbial composition tailored based on the microbial genotypes shown to be specific for A, B, and/or O blood groups.Type: ApplicationFiled: June 13, 2011Publication date: April 25, 2013Applicant: SUOMEN PUNAINEN RISTI VERIPALVELUInventors: Harri Makivuokko, Jaana Matto, Pirjo Wacklin, Jukka Partanen, Jarkko Rabina
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Publication number: 20130095086Abstract: An isolated Lactobacillus paracasei strain GMNL-133 is disclosed, which was deposited in the China Center for Type Culture Collection (CCTCC) under the accession number of CCTCC M 2011331 is disclosed. The isolated Lactobacillus paracasei strain GMNL-133 is used for preparing a composition for use in the treatment of atopic dermatitis or other allergic diseases in an effective amount. And a composition for use in the treatment of atopic dermatitis or other allergic diseases comprises an effective amount of the Lactobacillus paracasei strain GMNL-133 is also disclosed.Type: ApplicationFiled: October 14, 2011Publication date: April 18, 2013Applicant: GENMONT BIOTECH INCORPORATIONInventors: Ying-Chen LU, Feng-Ching HSIEH
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Patent number: 8420074Abstract: Lactobacillus strains that have a genetic Profile I based on Apa I, Not I, and Xba I digests are provided. Preferably, the strains decrease level of at least one of coliforms and E. coli within the gastrointestinal tract of an animal. A direct-fed microbial that includes the strain is additionally provided. A method of feeding an animal the strain and a method of forming a direct fed microbial that includes the strain is also provided.Type: GrantFiled: June 14, 2012Date of Patent: April 16, 2013Assignee: DuPont Nutrition Biosciences ApSInventors: Thomas G. Rehberger, Charles V. Maxwell
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Patent number: 8420376Abstract: The present technology relates to the use of at least one strain of probiotic bacteria selected from Lactobacillus for the manufacture of a pharmaceutical composition for the treatment and/or prevention of a virus infection.Type: GrantFiled: October 6, 2006Date of Patent: April 16, 2013Assignee: Probi ABInventors: Jan Alenfall, Anna Berggren, Carola Rask, Agnes Wold
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Publication number: 20130089633Abstract: This invention provides an effective means or method for improving lipid metabolism, and a means or method for treatment or prevention of diseases or disorders associated with the lipid metabolism disorder. Specifically, this invention relates to an agent for improving the lipid metabolism comprising, as active ingredients, broken cells of a lactic acid bacterium, and to a method for enhancing an effect of a lactic acid bacterium for improving the lipid metabolism comprising a step of breaking the lactic acid bacterium.Type: ApplicationFiled: June 8, 2011Publication date: April 11, 2013Applicant: CALPIS CO., LTD.Inventors: Futoshi Nakamura, Yu Ishida, Shigeru Fujiwara
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Patent number: 8415135Abstract: Provided is an isolated Lactobacillus plantarum CMU995, which was deposited at the Food Industry Research and Development Institute in Taiwan with the accession number BCRC 910472 and in the German Collection of Microorganisms and Cell Cultures (DSMZ) under accession number DSM 23780. Also provided are a composition comprising Lactobacillus plantarum CMU995 and a method for inhibiting pathogens, protecting the gastrointestinal tract, and/or protecting the urinary tract in a mammal comprising administrating an effective amount of Lactobacillus plantarum CMU995 to the mammal.Type: GrantFiled: August 25, 2010Date of Patent: April 9, 2013Assignee: China Medical UniversityInventor: Wen-Hsin Lin
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Publication number: 20130084623Abstract: The invention relates to the new, genetically non-modified bacterial strain Lactobacillus plantarum S, which has been deposited in the IAFB Collection of Industrial Microorganisms Institute of Agricultural and Food Biotechnology in Warsaw under the number KKP 2021 p or variant thereof. The invention relates to use of the strain Lactobacillus plantarum S KKP 2021 p or variant thereof or composition which may comprise thereof for ensiling of roughages, with the intention to decontaminate the feeds, contaminated with ochratoxin A, moulds and pathogenic bacteria. The feeds contaminated with moulds, ochratoxin A and pathogenic microorganisms, after the process of lactic fermentation with the participation of bacteria of the new strain Lactobacillus plantarum S, may be employed in nutrition of breeding animals as being completely safe products.Type: ApplicationFiled: November 26, 2012Publication date: April 4, 2013Applicant: Instytut Biotechnologii Przemysul Ronlno-SpozywczegoInventor: Instytut biotechnologii przemysul rolno-spozywcze
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Patent number: 8409642Abstract: Ferulate esterase producing bacterial strains or functional mutants thereof and methods of using ferulate esterase producing bacterial strains as forage additives are disclosed.Type: GrantFiled: September 18, 2008Date of Patent: April 2, 2013Assignee: Pioneer Hi-Bred International, Inc.Inventors: Victor Nsereko, William Rutherford, Brenda Smiley, Annette Spielbauer
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Publication number: 20130064928Abstract: Disclosed is a novel lactic acid bacterium belonging to Lactobacillus plantarum, which has an excellent fermentative ability affording high achievable cell counts even if various vegetable or fruit juices are used as fermentative substrates. The lactic acid bacterium belonging to Lactobacillus plantarum is characterized by the achievable viable cell counts being 108 CFU/ml or more in both cases when 100% juice of grape or of orange is used as fermentative substrate.Type: ApplicationFiled: March 15, 2011Publication date: March 14, 2013Applicant: Kabushiki Kaisha Yakult HonshaInventors: Tohru Iino, Norie Masuoka, Fumiyasu Ishikawa, Koichi Yoshimura, Eiji Hayashida
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Publication number: 20130059790Abstract: The present invention concerns a process for preparation of a biomass comprising one or a more plantaricins A, N or K in association with the lactic acid bacteria used for the preparation and uses thereof in order to stimulate the barrier function of intestinal cells or human epidermal keratinocytes.Type: ApplicationFiled: January 4, 2011Publication date: March 7, 2013Applicant: GIULIANI S.p.A.Inventors: Giammaria Giuliani, Anna Benedusi, Marco Gobbetti, Raffaella Di Cagno, Maria De Angelis, Maria Calasso
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Patent number: 8389266Abstract: The present invention provides lactic acid bacteria which are suitable for use for dietary products and pharmaceuticals, and which can suppress the increase of blood uric acid level. Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2922, were found.Type: GrantFiled: November 27, 2008Date of Patent: March 5, 2013Assignee: Meiji Co., Ltd.Inventors: Hiroshi Tsuboi, Noriko Kaneko, Akina Satou, Akinori Kume, Katsunori Kimura
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Publication number: 20130052171Abstract: An immunomodulatory isolated Lactobacillus strain is disclosed. The isolated Lactobacillus strain (accession No. CCTCC M 2011279) is purified from plant fermentation products. The isolated Lactobacillus strain, whatever itself or the composition including the same, can specifically enhance the amount of nitric oxide (NO), tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6), and also specifically enhance phagocytosis of macrophages, thereby enhancing the immunomodulatory ability of a host. Moreover, the isolated Lactobacillus strain of the present invention itself, or a food or its ingredient, a food supplement or a medical composition including the isolated Lactobacillus strain, can enhance the immunomodulatory ability by oral administration.Type: ApplicationFiled: March 21, 2012Publication date: February 28, 2013Applicant: CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCEInventors: Chen-Kai CHANG, Shu-Chen WANG, Pin-Der DUH
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Publication number: 20130045185Abstract: The disclosure relates to strains, compositions and methods for detoxifying a mycotoxin. In another embodiment, the disclosure relates to strains, compositions and methods for alleviating the gastrointestinal inflammatory response resulting from ingestion of mycotoxins. In one embodiment, the strains are Bacillus strains. In another embodiment, the strains are lactic acid bacteria.Type: ApplicationFiled: August 17, 2012Publication date: February 21, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Mari Ellen Davis, Joshua Rehberger, Kimberly Novak, Thomas G. Rehberger
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Publication number: 20130045291Abstract: It is to provide a composition derived from lactic acid bacteria having an anti-allergic effect (an effect of suppressing allergic symptoms such as hay fever) synergistically, and a food product, pet food, etc. containing the composition. It is to prepare a composition having an anti-allergic action, containing Lactobacillus crispatus KT-11 strain, KT-23 strain, or KT-25 strain bacterial cells and viable bacteria, dead bacteria, or a processed product of bacterial cells of other lactic acid bacteria belonging to the genus Lactobacillus, genus Bifidobacterium, genus Leuconostoc, genus Enterococcus, genus Pediococcus, etc. at a biomass-converted ratio of 99:1 to 50:50, preferably 99:1 to 75:25.Type: ApplicationFiled: March 4, 2011Publication date: February 21, 2013Applicant: KITII CO., LTD.Inventors: Keisuke Tobita, Hajime Otani
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Patent number: 8377430Abstract: The invention relates to an infant formula comprising a source of protein in an amount of not more than 2.0 g/100 kcal, a source of lipids, a source of carbohydrate and a probiotic wherein the probiotic is present in an amount equivalent to between 102 and 105 cfu/g of dry formula. The invention further extends to the use of such an infant formula to modulate the immune system of a neonatal infant to promote the development in the first few weeks of the life of the infant of a beneficial intestinal microbiota comparable with that found in breast fed babies as well as to promote the maturation of the immune system of a neonatal infant in the first few weeks of life.Type: GrantFiled: April 10, 2006Date of Patent: February 19, 2013Assignee: Nestec S.A.Inventors: Anne Donnet-Hughes, Eduardo Schiffrin, Ferdinand Haschke, Marie-Claire Fichot, Karl-Josef Huber-Haag
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Patent number: 8377679Abstract: The present invention pertains to the use of probiotics for the preparation of a carrier for balancing the skin's immune function. In particular, the present invention pertains to the use of probiotic micro-organisms for balancing the skin's immune function under stress conditions, such as a exposure to ultraviolet radiation, specifically for enhancing the skin's immune activity and reducing the tendency to develop allergic reactions under such conditions.Type: GrantFiled: August 7, 2009Date of Patent: February 19, 2013Assignee: Nestec S.A.Inventors: Markus Baur, Lionel Breton, Francois Couzy, Audrey Gueniche
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Patent number: 8372392Abstract: An isolated Lactobacillus paracasei strain LT12 and its genetically-engineered variant that possesses immune regulating activity and uses thereof for regulating immune responses and treating allergy.Type: GrantFiled: December 23, 2009Date of Patent: February 12, 2013Assignee: Lytone Enterprise, Inc.Inventors: William Tien Hung Chang, Yi Chieh Wang, Shu Ling Li
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Publication number: 20130028877Abstract: The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicating L. johnsonii La1 NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.Type: ApplicationFiled: May 7, 2010Publication date: January 31, 2013Applicant: NESTEC S.A.Inventors: Valerie Petit, Clara Garcia-Rodenas, Monique Julita, Guenolee Prioult, Annick Mercenier, Sophie Nutten
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Patent number: 8361778Abstract: The present invention relates to the field of fermentation media. More specifically, the invention provides a method for preparing a composition useful for culturing microbial cells wherein whole and/or autolysed yeast cells are enzymatically treated to obtain the composition. The microbial cultures obtained have increased stability and are useful in the manufacturing of food, feed and as a pharmaceutical product.Type: GrantFiled: October 16, 2006Date of Patent: January 29, 2013Assignee: Chr. Hansen A/SInventor: Dirk Bergmaier
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Patent number: 8361481Abstract: An object aims to develop a lactic acid bacterium having an anti-allergic activity, which can be grown by using rice, particularly polished white rice, and can be collected, cooked and ingested together with rice in such a state that the lactic acid bacterium is attached to the surface of the rice. Another object aims to develop a food composition and a pharmaceutical composition, each of which comprises rice containing the lactic acid bacterium as a material. Thus, disclosed are: a lactic acid bacterium Lactobacillus paracasei K71 strain which has been internationally deposited in National Institute of Advanced Industrial Science and Technology, International Patent Organism Depositary under Accession No.Type: GrantFiled: April 24, 2009Date of Patent: January 29, 2013Assignee: Kameda Seika Co., Ltd.Inventors: Takashi Hara, Toshio Joh, Takehisa Kumagai, Mariko Saito, Kimiko Uchiyama
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Publication number: 20130022586Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: ApplicationFiled: July 19, 2012Publication date: January 24, 2013Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Patent number: 8354272Abstract: An expression cassette comprising: a) a bacterial promoter, pZn, containing a binding site for the Lactococcus lactis ZitR protein, which site comprises the following sequence: AAAAATAANGTNNNNNNNTTGACATTATTTTT, (SEQ?ID?NO:?1) in which TTGACA is the ?35 box of said promoter, and N represents A, C, G or T; b) a sequence encoding a polypeptide with at least 80% identity with the Lactococcus lactis ZitR protein, placed under the transcriptional control of said promoter; and wherein the polypeptide is obtained from Lactococcus; and c) at least one restriction site allowing the insertion of a nucleotide sequence of interest under the transcriptional control of said promoter, and wherein the expression cassette does not comprise any part of the sequence encoding the L. lactis ZitS protein.Type: GrantFiled: November 9, 2005Date of Patent: January 15, 2013Assignee: Institut National de la Recherche AgronomiqueInventors: Isabelle Poquet, Daniel Llull
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Publication number: 20130011516Abstract: The present invention discloses a method for producing a fermented dairy product, preferably cheese, comprising inoculating milk with lactic acid bacteria capable of producing a Class IIa type bacteriocin; and lactic acid bacteria capable of producing a Class I type bacteriocin.Type: ApplicationFiled: July 3, 2012Publication date: January 10, 2013Inventors: Carmel GRIFFIN, Susan Mills, Paul Ross, Willem Cornelis Meijer, Lourdes Mariela Serrano Davalos
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Patent number: 8343483Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.Type: GrantFiled: October 15, 2008Date of Patent: January 1, 2013Assignee: Biogaia ABInventors: Bo Mollstam, Eamonn Connolly
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Publication number: 20120328586Abstract: Described are microorganisms which are, in a first aspect, able to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Applicant: Organobalance GmbHInventors: Christine Lang, Andreas Heilmann, Markus Veen, Eckhard Budde, Mewes Boettner, Andreas Reindl, Rolf Knöll
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Publication number: 20120329048Abstract: The present invention relates to a new method of establishing the authenticity and origin of dairy products, more specifically to the use of lactic acid bacterial strains having strain-specific insertion sequence elements as tools for marking dairy products (such as cheese) and identification thereof. The invention also extends to new lactic acid bacterial strains, their use in the production of dairy products as well as the dairy products containing these bacterial strains.Type: ApplicationFiled: October 1, 2010Publication date: December 27, 2012Applicant: AGROSCOPE LIEBEFELD-POSIEUX ALPInventor: Hélène Berthoud
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Patent number: 8338163Abstract: The present invention provides a triple vital bacteria composition, including: powder of Bifidobacterium longum, powder of Lactobacillus acidophilus, and powder of Streptococcus faecalis. The present invention further provides a method for preparing the above triple vital bacteria composition, as well as the protection agents, fermenting culture medium and seed culture medium used therein.Type: GrantFiled: February 3, 2008Date of Patent: December 25, 2012Assignee: Shanghai Sine Pharmaceutical Laboratories Co., Ltd.Inventors: Binhua Chen, Xuesong Wang, Liang Zhang
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Patent number: 8338147Abstract: High concentration of free cells of heterofermentative lactic acid bacteria (LAB) in a resting or slowly growing state are used to convert fructose into mannitol. Efficient volumetric mannitol productivities and mannitol yields from fructose are achieved in a process applying cell-recycle, continuous stirred tank reactor and/or circulation techniques with native LAB cells or with LAB cells with inactivated fructokinase gene(s). Mannitol is recovered in high yield and purity with the aid of evaporation and cooling crystallization.Type: GrantFiled: May 13, 2010Date of Patent: December 25, 2012Assignee: zuChem, Inc.Inventors: Niklas von Weymarn, Ulla Airaksinen
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Patent number: 8338162Abstract: The present invention provides an obligately anaerobic lactic acid bacterium having no risk of causing side effects in normal tissue and promising as a safe therapeutic agent and a gene transporter for a disease that is in an anaerobic environment such as a solid tumor, a preparation method therefor, and an expression vector useful in the preparation method. The obligately anaerobic lactic acid bacterium of the present invention has been artificially mutated from being facultatively anaerobic to being obligately anaerobic and, furthermore, is capable of being transformed by an expression vector having introduced thereinto a gene for expressing an active protein useful for the treatment of a disease that is in an anaerobic environment.Type: GrantFiled: April 17, 2009Date of Patent: December 25, 2012Assignee: Anaeropharma Science, Inc.Inventors: Shizunobu Igimi, Minoru Fujimori, Shun'ichiro Taniguchi, Michihiko Harada, Takayuki Sasaki, Akinobu Kajikawa
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Publication number: 20120321718Abstract: The present invention relates to genetically engineered bacteria that are able to colonize the mammalian intestine and actively produce mammalian lactase (lactose-phlorizin hydrolase or LPH). This lactose-digesting enzyme is stable and active under the conditions normally found in the mammalian small intestine. Experimental subjects colonized with the genetically engineered bacteria show improved ability to digest lactose in dairy foods.Type: ApplicationFiled: July 6, 2012Publication date: December 20, 2012Inventors: Kenneth Manzo, Jay Sharma
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Patent number: 8334128Abstract: The present invention relates to the novel Sporolactobacillus vineae SL153 strain (Accession No: KCTC 11493BP) having probiotic activity, precisely Sporolactobacillus vineae SL153 having antimicrobial activity against Vibrio genus pathogenic microorganisms and other pathogens. The Sporolactobacillus vineae SL153 strain of the present invention has excellent intestinal adherence and growth inhibitory effect on pathogenic microorganisms including Vibrio genus microorganisms, so that it can be effectively used as a composition for the prevention and treatment of disease caused by pathogenic microorganisms.Type: GrantFiled: July 17, 2009Date of Patent: December 18, 2012Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Young-Hyo Chang, Min-Young Jung, In-Soon Park
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Patent number: 8329447Abstract: The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.Type: GrantFiled: December 9, 2009Date of Patent: December 11, 2012Assignee: Osel, Inc.Inventors: Yang Liu, Rosa R. Yu, Andrew Cheng, Qing Xia, Qiang Xu
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Publication number: 20120308539Abstract: Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.Type: ApplicationFiled: July 9, 2012Publication date: December 6, 2012Applicant: MEIJI DAIRIES CORPORATIONInventors: Hiroshi Tsuboi, Noriko Kaneko, Akina Satou, Yoshinobu Tsuchiya
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Patent number: 8323951Abstract: The invention relates to novel strains of Lactobacillus helveticus. More specifically, the invention relates to strains of Lactobacillus helveticus having a lactose-negative phenotype and to the uses thereof in the agri-food industry. The invention also relates to a method for obtaining such strains of Lactobacillus helveticus.Type: GrantFiled: February 19, 2007Date of Patent: December 4, 2012Assignee: Compagnie Gervais DanoneInventors: Peggy Garault, Anne Druesne, Jean-Michael Faurie, Claire Queguiner, Thierry Saint-Dennis, Tamara Smokvina
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Publication number: 20120301575Abstract: The present invention relates to a bacterial cell with texturizing property, starter cultures comprising the cell, and dairy products fermented with the starter culture.Type: ApplicationFiled: January 28, 2011Publication date: November 29, 2012Inventors: Thomas Janzen, Ditte Ellegaard Christiansen
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Patent number: 8318151Abstract: The present invention generally relates to the field of weight management and obesity. In particular the present invention relates to the use of probiotics in combination with prebiotics to treat or prevent obesity. One embodiment of the present invention relates to the use of Lactobacillus rhamnosus NCC 4007 in combination with a specific probiotic mixture for the preparation of a composition to support weight management, promote weight loss and/or to treat obesity.Type: GrantFiled: February 4, 2010Date of Patent: November 27, 2012Assignee: Nestec S.A.Inventors: Christian Darimont-Nicolau, David Philippe, Catherine Mace, Fabrizio Arigoni
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Patent number: 8318150Abstract: The present invention generally relates to the field of obesity. In particular the present invention relates to the use of probiotics to support weight management and to treat or prevent obesity. One embodiment of the present invention relates to the use of Lactobacillus rhamnosus CNCM I-4096 for the preparation of a composition to support weight management, promote weight loss and/or to treat obesity.Type: GrantFiled: February 4, 2010Date of Patent: November 27, 2012Assignee: Nestec S.A.Inventors: Fabrizio Arigoni, Christian Darimont-Nicolau, Catherine Mace
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Publication number: 20120294833Abstract: The present invention relates to novel strains of lactic acid bacteria, Lactobacillus plantarum subsp. plantarum PM-A0087 deposited as NRRL accession number B-50523, Bifidobacterium longum PM-A0101 deposited as NRRL accession number B-50525, and Bifidobacterium bifidum PM-A0218 deposited as NRRL accession number B-50524.Type: ApplicationFiled: May 14, 2012Publication date: November 22, 2012Applicant: PROMD BIOTECH. CO., LTD.Inventors: WEI-CHIH SU, KUANG-CHIH LEE, HSIANG-LING CHEN, HSIAO-LI WU
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Patent number: 8309076Abstract: The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body.Type: GrantFiled: May 14, 2007Date of Patent: November 13, 2012Assignee: Bioneer CorporationInventors: Ji Hee Kang, Byeung Il You, Sung Il Yun, Han Oh Park