Transformants Patents (Class 435/254.11)
Yeast; media therefor (Class 435/254.2)
Aspergillus (Class 435/254.3)
Neurospora (Class 435/254.4)
Penicillium (Class 435/254.5)
Trichoderma (Class 435/254.6)
Fusarium (Class 435/254.7)
Mucor (Class 435/254.8)
Rhizopus (Class 435/254.9)
  • Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same
    Publication number: 20140234907
    Abstract: Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 16, 2012
    Publication date: August 21, 2014
    Applicant: Novozymes Inc.
    Inventors: Yu Zhang, Ye Liu, Junxin Duan, Lan Tang
  • ALPHA-GLUCANASE AND ORAL CARE COMPOSITION CONTAINING THE SAME
    Publication number: 20140234231
    Abstract: Isolated ?-glucanases from Hypocrea tawa, Trichoderma reesei, and Trichoderma konilangbra are described, as well as oral care compositions containing the same. The oral care composition may be employed to prevent or reduce dental plaque.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 21, 2014
    Applicant: DANISCO US INC.
    Inventors: Steven Kim, Suzanne Lantz, Michael Pepsin
  • BUTTIAUXELLA SP. PHYTASE VARIANTS
    Publication number: 20140234490
    Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.
    Type: Application
    Filed: January 22, 2014
    Publication date: August 21, 2014
    Applicant: Danisco US Inc.
    Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K. Shetty, Michael Pepsin, Soren Dalsgaard, Mai Faurschou Isaksen
  • Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
    Publication number: 20140234897
    Abstract: Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains are disclosed.
    Type: Application
    Filed: November 2, 2012
    Publication date: August 21, 2014
    Inventors: Yu Zhang, Junxin Duan, Ye Liu, Lan Tang
  • PHOSPHATIDIC ACID PHOSPHATASE GENE
    Publication number: 20140234941
    Abstract: The present invention provides a novel phosphatidic acid phosphatase gene. The object of the present invention can be solved by providing a nucleic acid comprising the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 4, or SEQ ID NO: 5; a protein comprising the amino acid sequence set forth in SEQ ID NO: 2; and mutants thereof.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 21, 2014
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventor: Misa Ochiai
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140234208
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 21, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • VARIANTS OF GLYCEROL DEHYDROGENASE HAVING D-LACTATE DEHYDROGENASE ACTIVITY AND USES THEREOF
    Publication number: 20140234924
    Abstract: The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants and methods of producing lactic acids are also provided in various aspects of the invention.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 21, 2014
    Inventors: Qingzhao Wang, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
  • Polypeptides Having Peroxygenase Activity and Polynucleotides Encoding Same
    Publication number: 20140234918
    Abstract: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: August 21, 2014
    Applicant: Novozymes A/S
    Inventors: Sara Landvik, Lars Henrik Oestergaard, Lisbeth Kalum
  • Methods for improving malic acid production in filamentous fungi
    Publication number: 20140234925
    Abstract: The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 21, 2014
    Applicant: Novozymes, Inc.
    Inventors: Stephen Brown, Sheryl Luttringer, Debbie Yaver, Alan Berry
  • MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO
    Publication number: 20140235815
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
    Type: Application
    Filed: October 21, 2013
    Publication date: August 21, 2014
    Applicant: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Variants of glucoamylase
    Patent number: 8809023
    Abstract: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: August 19, 2014
    Assignee: Danisco US Inc.
    Inventors: Peter Edvard Degn, Richard Bott, Casper Willem Vroemen, Martijn Silvan Scheffers, Wolfgang Aehle
  • PERFORMANCE-ENHANCED AND TEMPERATURE-RESISTANT PROTEASE VARIANTS
    Publication number: 20140227764
    Abstract: Proteases that comprise an amino acid sequence that is at least 70% identical to the amino acid sequence indicated in SEQ ID NO. 1 over its entire length and that comprise, in the count in accordance with SEQ ID NO. 1, the amino acid substitution R99E or R99D in combination with at least two further amino acid substitutions that are selected from the group consisting of S3T, V4I, and V199I, display very good cleaning performance in particular on blood-containing stains, as well as very good temperature stability.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 14, 2014
    Applicant: Henkel AG & Co. KGaA
    Inventors: Hendrik Hellmuth, Marion Merkel, Brian Laufs, Susanne Wieland, Timothy O'Connell, Susanne Tondera, Thomas Weber
  • Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
    Publication number: 20140230096
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: June 24, 2013
    Publication date: August 14, 2014
    Applicant: Novozymes Inc.
    Inventor: Nikolaj Spodsberg
  • GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES
    Publication number: 20140227754
    Abstract: The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 14, 2014
    Applicant: Danisco US Inc.
    Inventors: Wolfgang Aehle, Richard R. Bott, Martijn Scheffers, Pieter van Solingen, Casper Vroemen
  • PROLACTIN RECEPTOR BINDING PROTEINS AND USES THEREOF
    Publication number: 20140227294
    Abstract: The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
    Type: Application
    Filed: December 23, 2013
    Publication date: August 14, 2014
    Applicant: ABBVIE INC.
    Inventors: Mark Anderson, Jieyi Wang, Archana Thakur, Debra Chao, Chung-Ming Hsieh, Qian Zhang, Edward B. Reilly, Enrico L. DiGiammarino, Kenton L. Longenecker, Russell A. Judge, David A. Egan, Charles W. Hutchins
  • AMYLOID-BETA BINDING PROTEINS
    Publication number: 20140227291
    Abstract: The present invention relates to amyloid-beta (A?) binding proteins. Antibodies of the invention have high affinity to A?(20-42) globulomer or any A? form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
    Type: Application
    Filed: August 12, 2011
    Publication date: August 14, 2014
    Inventors: Stefan Barghorn, Heinz Hillen, Andreas Striebinger, Simone Giasi, Ulrich Ebert, Chung-Ming Hsieh
  • UNCONVENTIONAL PROTEIN SECRETION
    Publication number: 20140227727
    Abstract: The present invention relates to an expression cassette comprising a nucleotide sequence encoding an amino acid sequence, a fragment or variant thereof which directs unconventional protein secretion and a nucleotide sequence encoding a protein of interest. Also contemplated is a vector which comprises the expression cassette, host cells comprising the vectors as well as methods and uses for the production of a polypeptide of interest.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 14, 2014
    Inventor: Michael Feldbruegge
  • Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same
    Publication number: 20140230098
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: June 27, 2013
    Publication date: August 14, 2014
    Inventor: Nikolaj Spodsberg
  • Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same
    Publication number: 20140227739
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: February 12, 2013
    Publication date: August 14, 2014
    Inventor: Nikolaj Spodsberg
  • Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same
    Publication number: 20140230097
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: June 24, 2013
    Publication date: August 14, 2014
    Inventor: Nikolaj Spodsberg
  • Polypeptides Having Protease Activity and Polynucleotides Encoding Same
    Publication number: 20140227738
    Abstract: The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 14, 2014
    Applicant: Novozymes A/S
    Inventors: Jeppe Wegener Tams, Tine Hoff, Morten Gjermansen, Peter Rahbek Oestergaard, Robert Piotr Olinski, Katrine Pontoppidan, Carsten Sjoeholm
  • Mutant polyhydroxyalkanoic acid synthase gene and method for producing aliphatic polyester using the same
    Patent number: 8802402
    Abstract: A substitution mutation that improves polymerization activity of a polyhydroxyalkanoic acid synthase is identified. At least 1 amino acid residue selected from the group consisting of a histidine residue at position 17, a proline residue at position 71, a valine residue at position 131, a methionine residue at position 205, a leucine residue at position 230, and a proline residue at position 239 of a polyhydroxyalkanoic acid synthase derived from Alcanivorax borkumensis is subjected to substitution mutation with another amino acid.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: August 12, 2014
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Masayoshi Muramatsu, Hiromi Kambe, Masakazu Ito
  • Novel VISTA-Ig constructs and the use of VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders
    Publication number: 20140220012
    Abstract: The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.
    Type: Application
    Filed: June 24, 2013
    Publication date: August 7, 2014
    Inventors: Randolph J. Noelle, Sabrina Ceeraz, Isabelle LeMercier, Elizabeth Nowak, Janet Lines
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140219912
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • SERUM HALF-LIFE EXTENSION USING IGBD
    Publication number: 20140220017
    Abstract: The present invention relates to complexes comprising (i) an immunoglobulin (Ig) binding moiety and (ii) a pharmaceutically active moiety, wherein the Ig binding moiety specifically binds to the constant domain 1 of the heavy chain (CH1) of an Ig molecule and their use for therapy and prophylaxis.
    Type: Application
    Filed: September 24, 2012
    Publication date: August 7, 2014
    Inventors: Roland Kontermann, Felix Unverdorben, Meike Hutt
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140220019
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    Publication number: 20140223602
    Abstract: The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ?-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.
    Type: Application
    Filed: September 27, 2013
    Publication date: August 7, 2014
    Applicant: BP Corporation North America LLC
    Inventors: Cathy Chang, Justin T. Stege, Nahla M. Aboushadi, Gordana Djordjevic, Ellen G. Burke, Peter Luginbuhl, Mark Dycaico, Toby H. Richardson, John Poland, Hefner Ying, Stacy M. Miles
  • Alpha-Amylase Variants and Polynucleotides Encoding Same
    Publication number: 20140220635
    Abstract: The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: October 17, 2012
    Publication date: August 7, 2014
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Signe Larsen, Esben Peter Friis, Pernille Ollendorff Micheelsen, Anders Viksoe Nielsen, Randall Deinhammer, Xinyu Shen
  • USE OF JAZ5A FOR IMPROVING DROUGHT-RESISTANCE IN A PLANT
    Publication number: 20140223596
    Abstract: The present invention provides use of a plant gene JAZ5a for improving drought-resistance of a plant. It further provides a method for improving the drought-resistance of a plant, comprising enhancing the expression or activity of Jaz5A in said plant.
    Type: Application
    Filed: July 5, 2012
    Publication date: August 7, 2014
    Inventor: Adrianus Johannes Van Tunen
  • FILAMENTOUS FUNGI HAVING AN ALTERED VISCOSITY PHENOTYPE
    Publication number: 20140220689
    Abstract: Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.
    Type: Application
    Filed: April 20, 2012
    Publication date: August 7, 2014
    Applicant: DANISCO US INC.
    Inventors: Elizabeth A. Bodie, Robert James Pratt, II
  • Dual Specific Binding Proteins Having a Receptor Sequence
    Publication number: 20140219913
    Abstract: Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 27, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq Ghayur, Philip Bardwell
  • PHAGE &phgr;MRU POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF
    Publication number: 20140220636
    Abstract: The invention encompasses phage ?mru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors. The invention further encompasses compositions and methods for detecting, targeting, permeabilising, and inhibiting microbial cells, especially methanogen cells, using the disclosed phage, polypeptides, polynucleotides, expression vectors, or host cells.
    Type: Application
    Filed: October 25, 2013
    Publication date: August 7, 2014
    Applicant: Pastoral Greenhouse Gas Research Limited
    Inventors: Eric Heinz Altermann, Graeme Trevor Attwood, Sinead Christine Leahy, William John Kelly, Robert Starr Ronimus, Dong Li, Zhanhao Kong, Linley Rose Schofield, Debjit Dey, Catherine Mary Totill, Carrie Sang, Christina Diane Moon, Petrus Hendricus Janssen
  • Production of glycoproteins with reduced O-glycosylation
    Patent number: 8795984
    Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: August 5, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Piotr Bobrowicz, W. James Cook, Warren Kett
  • OVER-EXPRESSION OF A PUTATIVE OXIDOREDUCTASE (UCPA) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE
    Publication number: 20140212933
    Abstract: The subject invention pertains to overexpression of a putative oxidoreductase (ucpA) for increasing furfural tolerance in genetically modified microorganisms. Genetically modified microorganisms capable of overexpressing UcpA are also provided. Increased expression of ucpA was shown to increase furfural tolerance by 50%, and to permit the fermentation of sugars to products in the presence of 15 mM furfural.
    Type: Application
    Filed: July 9, 2012
    Publication date: July 31, 2014
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Xuan Wang, Elliot N. Miller, Lorraine P. Yomano, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
  • Methods For Producing Multiple Recombinant Polypeptides In A Filamentous Fungal Host Cell
    Publication number: 20140212977
    Abstract: The present invention relates to methods for constructing a filamentous fungal strain for production of multiple recombinant polypeptides having biological activity. The present invention also relates to methods for producing multiple recombinant polypeptides having biological activity in a filamentous fungal strain. The present invention also relates to filamentous fungal strains expressing multiple recombinant polypeptides having biological activity.
    Type: Application
    Filed: August 23, 2012
    Publication date: July 31, 2014
    Inventors: Debbie Yaver, Qiming Jin
  • METHODS AND COMPOSITIONS FOR TARGETED SINGLE-STRANDED CLEAVAGE AND TARGETED INTEGRATION
    Publication number: 20140212928
    Abstract: Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 31, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventor: Jianbin Wang
  • Methods of Treatment Using A Pentapeptide Derived From The C-Terminus Of Glucagon-Like Peptide 1 (GLP-1)
    Publication number: 20140212472
    Abstract: Methods of treating obesity, metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes using a pentapeptide, LVKGRamide, derived from the C-terminus of Glucagon-Like Peptide 1 (GLP-1).
    Type: Application
    Filed: July 5, 2012
    Publication date: July 31, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Joel F. Habener, Eva Tomas-Falco
  • POLYPEPTIDE HAVING INDUCING ACTIVITY FOR THE DEFENCE AGAINST BIOTIC STRESS IN PLANTS, NUCLEOTIDE SEQUENCE ENCODING THE SAME, MICROORGANISM, COMPOSITIONS AND METHODS
    Publication number: 20140212385
    Abstract: Polypeptide having activity inducing pathogen plant defence, nucleotide sequence encodes it, microorganism, compositions and methods. The polypeptide is a subtilisin derived from a strain of Acremonium strictum. The polypeptide is encoded by the nucleotide sequence SEQ ID No.: 1 or sequences at least 90% homologous to the same and has the amino acid sequence SEQ ID No: 2 or sequences at least 90% homologous to the same.
    Type: Application
    Filed: March 16, 2012
    Publication date: July 31, 2014
    Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)
    Inventors: Atilio Pedro Castagnaro, Juan Carlos Diaz Ricci, Nadia Regina Chalfoun, Josefina Racedo, Sergio Miguel Salazar
  • IL-1 BINDING PROTEINS
    Publication number: 20140212925
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 17, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • PCSK9-BINDING POLYPEPTIDES AND METHODS OF USE
    Publication number: 20140212431
    Abstract: The invention provides PCSK9-binding polypeptides and methods of using the same.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 31, 2014
    Applicant: GENENTECH, INC.
    Inventors: Daniel K. Kirchhofer, Yingnan Zhang, Andrew Scott Peterson, Wei Li, Monica Kong-Beltran, Lijuan Zhou
  • Microorganisms having enhanced tolerance to inhibitors and stress
    Patent number: 8790902
    Abstract: The present invention provides genetically modified strains of microorganisms that display enhanced tolerance to stress and/or inhibitors such as sodium acetate and vanillin. The enhanced tolerance can be achieved by increasing the expression of a protein of the Sm-like superfamily such as a bacterial Hfq protein and a fungal Sm or Lsm protein. Further, the present invention provides methods of producing alcohol from biomass materials by using the genetically modified microorganisms of the present invention.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: July 29, 2014
    Assignee: UT-Batelle, LLC
    Inventors: Steven D. Brown, Shihui Yang
  • Metabolic engineering of xylose-fermenting eukaryotic cells
    Patent number: 8790903
    Abstract: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include. e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: July 29, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Aaron Adriaan Winkler, Sipko Maarten Kuyper, Wilhelmus Theordorus Antonius Maria De Laat, Johannes Pieter Van Dijken, Jacobus Thomas Pronk
  • Mutant cellobiohydrolase
    Patent number: 8790894
    Abstract: The invention relates to Mutant cellobiohydrolase, being a mutant of SEQ ID NO:1, having a substitution at position N247(I,F,H,W) of SEQ ID NO: 1, wherein the mutant cellobiohydrolase has at least 50% sequence identity with SEQ ID NO: 1, and wherein the mutant cellobiohydrolase has CBHI activity.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: July 29, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Jan Metske Van Der Laan, Margot Elisabeth Francoise Schooneveld-Bergmans, Denise Ilse Jacobs
  • Lysophospholipid acyltransferase
    Patent number: 8790906
    Abstract: The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid sequences of SEQ ID NOs: 2 and 7 of the present invention.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: July 29, 2014
    Assignee: Suntory Holdings Limited
    Inventor: Misa Ochiai
  • Methods for Obtaining Positive Transformants of a Filamentous Fungal Host Cell
    Publication number: 20140206086
    Abstract: The present invention relates to methods for obtaining positive transformants of a filamentous fungal host cell, comprising: transforming a tandem construct into a population of cells of the filamentous fungal host a tandem construct and isolating a transformant of the filamentous fungal host cell comprising the tandem construct. The present invention also relates to such tandem constructs, filamentous fungal host cells comprising such tandem constructs, and methods of producing multiple recombinant proteins.
    Type: Application
    Filed: August 23, 2012
    Publication date: July 24, 2014
    Applicant: Novozymes, Inc.
    Inventor: Donna Moyer
  • T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
    Publication number: 20140206620
    Abstract: The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Steven A. Rosenberg, Richard A. Morgan, Timothy L. Frankel
  • AMINO ACID SEQUENCES DIRECTED AGAINST RANK-L AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF BONE DISEASES AND DISORDERS
    Publication number: 20140205601
    Abstract: The present invention relates to amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: December 11, 2013
    Publication date: July 24, 2014
    Applicant: Ablynx N.V.
    Inventors: Els Anna Alice Beirnaert, Sigrid Cornelis, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Polypeptides Having Protease Activity and Polynucleotides Encoding Same
    Publication number: 20140206594
    Abstract: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: June 22, 2012
    Publication date: July 24, 2014
    Inventors: Martin Simon Borchert, Jeppe Wegener Tams
  • POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20140206035
    Abstract: Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains.
    Type: Application
    Filed: August 24, 2012
    Publication date: July 24, 2014
    Inventors: Tianqi Sun, Ming Li
  • Thermostable Alpha-Amylases
    Publication number: 20140206045
    Abstract: The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the polypeptide selected from the group consisting of: a) a polypeptide comprising an amino acid sequence which has at least 70% identity with amino acids 22 to 450 of SEQ ID NO: 4; b) a polypeptide comprising an amino acid sequence which has at least 70% identity with the polypeptide encoded by the amylase encoding part of the polynucleotide inserted into a plasmid present in the E. coli host deposited under the Budapest Treaty with DSMZ under accession number DSM 15334; c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence which has at least 70% identity with the sequence shown from position 68 to 1417 in SEQ ID NO: 3; and d) a fragment of (a), (b) or (c) that has alpha-amylase activity.
    Type: Application
    Filed: March 31, 2014
    Publication date: July 24, 2014
    Applicant: Novozymes A/S
    Inventors: Lan Tang, Wenping Wu, Junxin Duan, Pia Francke Johannesen