Antigens Patents (Class 435/69.3)
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Patent number: 12215335Abstract: The present invention relates to a polynucleotide comprising at least one promoter and an S/MAR element, wherein the S/MAR element is located downstream of the promoter in the 3? UTR of the transcription unit and wherein the S/MAR element is flanked by a 5? splice donor site and a 3? splice acceptor site; the present invention further relates to a composition comprising the polynucleotide, and to the polynucleotide for use in medicine and for use in treating genetic disease.Type: GrantFiled: September 17, 2018Date of Patent: February 4, 2025Assignee: Deutsches KrebsforschungszentrumInventors: James A. Williams, Matthias Bozza, Richard Harbottle
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Patent number: 12171827Abstract: The invention relates to an immunogenic or vaccine composition against the 2019 novel coronavirus (SARS-COV-2), comprising a nucleic acid construct encoding a SARS-COV-2 coronavirus Spike (S) protein antigen or a fragment thereof comprising the receptor-binding domain, wherein the nucleic acid construct sequence is codon-optimized for expression in 5 human.Type: GrantFiled: March 25, 2024Date of Patent: December 24, 2024Assignee: INSTITUT PASTEURInventors: Etienne Simon-Loriere, Matthieu Prot, Xavier Montagutelli
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Patent number: 12162906Abstract: A method of preparing extracellularly assembled higher order antigen from a native lower order antigen the method comprising the following steps: (i) contacting lower order antigen with a solution comprising a reducing agent for a time and under 5 conditions sufficient to reduce one or more native cysteines; and (ii) removing or diluting the reducing agent or contacting the reduced lower order antigen with an oxidising agent, to elicit assembly of lower order antigen from (i) into an assembled higher order antigen; wherein at least 10% of the lower order antigen is converted to higher order antigen in step (ii) and whereby the assembled higher order antigen 10 displays at least reduced binding to non-neutralizing antibodies compared to the lower order antigen and retains binding to at least one neutralizing antibody.Type: GrantFiled: September 22, 2017Date of Patent: December 10, 2024Assignee: Macfarlane Burnet Institute for Medical Research and Public Health LimitedInventors: Heidi Drummer, Pantelis Poumbourios, Robert Center
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Patent number: 12163135Abstract: Methods and compositions are provided for durably influencing microbiological ecosystems (microbiomes) in a subject in order to prevent infection and reduce recurrence of infection by microorganisms. In some embodiments, compositions and methods are provided for the creation and use of molecularly-modified bacterial strains with the potential to prevent a variety of microorganism infections.Type: GrantFiled: December 4, 2018Date of Patent: December 10, 2024Assignee: BioPlx, Inc.Inventors: Timothy W. Starzl, Todd D. Turner, Ravi S. V. Starzl
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Patent number: 12128112Abstract: Produced the gene therapy DNA vectors based on the gene therapy DNA vector VTvaf17 for the treatment of diseases featuring disruption of mucociliary transport, mucolytic function and development of mucostasis. The gene therapy DNA vector contains the coding region of the SKI, TGFB3, TIMP2 or FMOD therapeutic genes. Methods of producing or use a gene therapy DNA vector based on gene therapy DNA vector VTvaf17 carrying SKI, TGFB3, TIMP2 or FMOD therapeutic genes. The methods of producing strain for production of gene therapy DNA vector for treatment of diseases featuring disruption of mucociliary transport and development of mucostasis. Escherichia coli strain SCS 110-AF/VTvaf17-SKI, SCS 110-AF/VTvaf17-TGFB3, SCS110-AF/VTvaf17-TIMP2 or SCSI 10-AF/VTvaf17-FMOD obtains by the method described above carrying gene therapy DNA vector VTvaf17-SKI, VTvaf17-TGFB3, VTvaf17-TIMP2 or VTvaf17-FMOD.Type: GrantFiled: August 14, 2019Date of Patent: October 29, 2024Assignees: OOO “PRORYVNYE INNOVATSIONNYE TEKHNOLOGII”, CELL AND GENE THERAPY LTDInventor: Natalia Savelieva
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Patent number: 12128078Abstract: Disclosed are immunogenic pharmaceutical compositions comprising yeast lysates for inducing cellular immune responses, methods of making immunogenic compositions comprising yeast lysates, methods of treatment comprising administration of said compositions, and kits comprising said yeast lysate compositions. Disclosed immunogenic compositions further comprise an antigen heterologous to the yeast, and may comprise whole yeast and immunostimulatory agents. Induced cellular immune responses comprise cytotoxic T cell activation with specificity to the antigen comprising the immunogenic composition. Various methods of formulation and administration to a patient are described herein, especially wherein the patient suffers from an infectious disease and/or cancer.Type: GrantFiled: May 13, 2019Date of Patent: October 29, 2024Assignee: GlobeImmune, Inc.Inventors: Thomas H. King, Zhimin Guo, Courtney Fleenor
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Patent number: 12128094Abstract: The invention provides an immunogenic composition comprising OMVs and (a) acellular pertussis antigen, (b) a tetanus toxoid and (c) a diphtheria toxoid, wherein the OMVs are derived from Bordetella pertussis. The invention also provides compositions for use in a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.Type: GrantFiled: November 4, 2019Date of Patent: October 29, 2024Assignee: GlaxoSmithKline Biologicals SAInventors: Mario Contorni, Mariagrazia Pizza, Anja Seubert
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Patent number: 12116412Abstract: Provided are polynucleotides and viral vectors, e.g., alphavirus or Sindbis viral vectors, encoding multiple, e.g., two or more, epitopes of at least one tumor associated antigen, in which each epitope is separated by a processing or enzyme cleavage site. The encoded epitopes may be the same or different. Also provided are polynucleotides and viral vectors, particularly, alphavirus or Sindbis viral vectors, encoding an immune checkpoint protein, or a ligand binding portion thereof. The immune checkpoint protein or ligand binding portion thereof may be fused to immunoglobulin domains, e.g., an Ig hinge domain and an Ig heavy chain constant domain. Methods of treating subjects having a cancer or tumor, e.g., a TAA-expressing tumor, with the described viral vectors are provided.Type: GrantFiled: March 5, 2018Date of Patent: October 15, 2024Assignee: New York UniversityInventors: Daniel Meruelo, Alicia Hurtado Martinez, Christine Pampeno, Iris Scherwitzl
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Patent number: 12090195Abstract: The present disclosure relates to a fully liquid immunogenic composition comprising a combination of antigens/immunogens. The immunogenic composition comprises optimum amount of antigens/immunogens to confer protection against a number of diseases. The composition exhibits improved immunogenicity and stability. A process for preparing the vaccine composition is also disclosed.Type: GrantFiled: October 4, 2019Date of Patent: September 17, 2024Assignee: Serum Institute of India Private LimitedInventors: Inder Jit Sharma, Rakesh Kumar, Jaganathan Semburakkiannan Kilvani, Manohar Doddapaneni, Anil Vyankatrao Shitole
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Patent number: 12091670Abstract: The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells.Type: GrantFiled: December 3, 2020Date of Patent: September 17, 2024Assignee: Universitaet BaselInventors: Cécile Arrieumerlou, Simon Ittig
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Patent number: 12090198Abstract: The present embodiments provide for a Mycobacterium tuberculosis (M. tuberculosis) Multiple Antigen Presenting System (MAPS) immunogenic composition comprising an immunogenic polysaccharide which induces an immune response, where at least one M. tuberculosis peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. In some embodiments, the immunogenic polysaccharide can be an antigenic capsular polysaccharide of a Mycobacterium tuberculosis, Type 5 (CP5) or Type 8 (CP8), or a combination of Type 5 or Type 8 capsular polysaccharide from Staphylococcus aureus, or alternatively, a different immunogenic capsular or noncapsular polysaccharide, and where the protein or peptide M. tuberculosis antigens are indirectly linked via an affinity binding pair. The present M. tuberculosis-MAPS immunogenic compositions can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one or multiple M. tuberculosis antigens at the same time.Type: GrantFiled: May 18, 2018Date of Patent: September 17, 2024Inventors: Fan Zhang, Richard Malley, Yingjie Lu
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Patent number: 12070494Abstract: The invention describes chimeric Flavivirus constructs comprising lyssavirus G proteins in the E/NS1 intergenic region.Type: GrantFiled: September 6, 2019Date of Patent: August 27, 2024Assignee: KATHOLIEKE UNIVERSITEIT LEUVENInventors: Kai Dallmeier, Niraj Mishra, Johan Neyts, Lorena Sanchez
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Patent number: 12048730Abstract: Provided is a pharmaceutical composition for preventing or treating cancer, containing, as an active ingredient, an oligopeptide usable in treating cancer. Since an oligopeptide of the presently claimed subject matter has a molecular weight lower than those of antibodies, there are advantages for less concern of an immune response and easily penetrating into tissues, and selectively acting on cancer cells or cancer tissues.Type: GrantFiled: December 13, 2019Date of Patent: July 30, 2024Assignee: L-BASE CO., LTD.Inventor: Do Yong Jeon
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Patent number: 11998635Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.Type: GrantFiled: April 20, 2020Date of Patent: June 4, 2024Assignee: Northwestern UniversityInventors: Joshua N. Leonard, Michelle E. Hung
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Patent number: 11988669Abstract: The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as presented per cell. The present invention can not only be used for the development of antibody therapies or peptide vaccines, but is also highly valuable for a molecularly defined immuno-monitoring, and useful in the processes of identifying of new peptide antigens for immunotherapeutic strategies, such as respective vaccines, antibody-based therapies or adoptive T-cell transfer approaches in cancer, infectious and/or autoimmune diseases.Type: GrantFiled: November 15, 2019Date of Patent: May 21, 2024Assignee: Immatics Biotechnologies GmbHInventors: Toni Weinschenk, Julia Leibold
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Patent number: 11981707Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.Type: GrantFiled: September 11, 2023Date of Patent: May 14, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Peter D. Kwong, Barney S. Graham, Jason S. McLellan, Jeffrey Boyington, Lei Chen, Man Chen, Gwo-Yu Chuang, Ivelin Stefanov Georgiev, Jason Gorman, Michael Gordon Joyce, Masaru Kanekiyo, Gilad Ofek, Marie Pancera, Mallika Sastry, Cinque Soto, Sanjay Srivatsan, Guillaume Stewart-Jones, Yongping Yang, Baoshan Zhang, Tongqing Zhou
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Patent number: 11866768Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.Type: GrantFiled: July 23, 2020Date of Patent: January 9, 2024Assignee: California Institute of TechnologyInventors: Emil P. Kartalov, Aditya Rajagopal, Axel Scherer
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Patent number: 11779606Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.Type: GrantFiled: January 22, 2021Date of Patent: October 10, 2023Assignee: IMMATICS BIOTECHNOLOGIES GMBHInventors: Heiko Schuster, Franziska Hoffgaard, Jens Fritsche, Oliver Schoor, Toni Weinschenk, Daniel Johannes Kowalewski, Chih-Chiang Tsou
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Patent number: 11767345Abstract: The synthetic peptide disclosed here includes (1) an amino acid sequence represented by any of SEQ ID NOS:1 to 10, or a modified amino sequence formed by deletion, substitution or addition of 1, 2 or 3 amino acid residues in any of these amino acid sequences, together with (2) an amino acid sequence (CPP sequence) that functions as a cell penetrating peptide (CPP), and consists of a total of not more than 100 amino acid residues.Type: GrantFiled: May 25, 2021Date of Patent: September 26, 2023Assignees: TOAGOSEI CO., LTD, National University Corporation Hokkaido UniversityInventors: Tetsuhiko Yoshida, Ayato Takada, Nahoko Baileykobayashi
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Patent number: 11730799Abstract: A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.Type: GrantFiled: June 29, 2021Date of Patent: August 22, 2023Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: David M. Lubaroff, Delbert L. Harris
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Patent number: 11693009Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.Type: GrantFiled: May 18, 2020Date of Patent: July 4, 2023Assignee: Cedars-Sinai Medical CenterInventors: Mark Pimentel, Christopher Chang
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Patent number: 11684669Abstract: Described herein are CpG-adjuvanted SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.Type: GrantFiled: September 10, 2021Date of Patent: June 27, 2023Assignees: Valneva Austria GmbH, Dynavax Technologies CorporationInventors: Andreas Meinke, Michael Möhlen, Christoph Reinisch, Robert Schlegl, Christian Taucher, John Campbell, David Novack, Robert S. Janssen, Jürgen Heindl-Wruss
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Patent number: 11667695Abstract: Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.Type: GrantFiled: October 10, 2019Date of Patent: June 6, 2023Assignee: Taiga Biotechnologies, Inc.Inventors: Yosef Refaeli, Brian Turner
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Patent number: 11649264Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: February 12, 2021Date of Patent: May 16, 2023Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite De Claude Bernard Lyon 1Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Patent number: 11572391Abstract: Disclosed are P. gingivalis antibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.Type: GrantFiled: November 13, 2020Date of Patent: February 7, 2023Assignee: Oral Health Australia PTY LtdInventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J. Cross, Nada Slakeski
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Patent number: 11528289Abstract: Security mechanisms for content delivery networks (“CDNs”) are disclosed herein. One security mechanism can be used to mitigate or prevent dynamic content attacks. A system can execute a CDN manager to perform operations. In particular, the CDN manager can receive a plurality of hypertext transfer protocol (“HTTP”) requests, and parse a plurality of headers from the plurality of HTTP requests to determine a plurality uniform resource locators (“URLs”). The CDN manager can generate a plurality of web page images associated with the plurality of URLs. The CDN manager can execute a machine learning algorithm, such as a convolution neural network, to perform an analysis of the plurality of web page images. Based upon the analysis of the plurality of web page images, the CDN manager can determine whether the plurality of HTTP requests are for the same web page, which can be indicative of a dynamic content attack.Type: GrantFiled: February 26, 2021Date of Patent: December 13, 2022Assignee: AT&T Intellectual Property I, L.P.Inventors: Joseph Soryal, Dylan C. Reid
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Patent number: 11472882Abstract: An anti-B7-H4 antibody, an antigen-binding fragment thereof and pharmaceutical use thereof. A chimeric antibody and a humanized antibody comprising a CDR region of the anti-B7-H4 antibody, a pharmaceutical composition comprising the anti-B7-H4 antibody and the antigen-binding fragment thereof, and use thereof as an anti-cancer medicament. A humanized anti-B7-H4 antibody and use thereof in the preparation of a medicament for treating diseases or conditions mediated by B7-H4.Type: GrantFiled: February 1, 2019Date of Patent: October 18, 2022Assignees: Jiangsu Hansoh Pharmaceutical Group Co., Ltd., Shanghai Hansoh Biomedical Co., Ltd.Inventors: Rudi Bao, Haiqing Hua, Suxia Liu, Fujun Zhang, Ting Wang
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Patent number: 11464846Abstract: The invention relates to a mutated HPV66 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV66 and HPV56, or HPV66, HPV56 and HPV53), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.Type: GrantFiled: June 4, 2019Date of Patent: October 11, 2022Assignees: XIAMEN UNIVERSITY, XIAMEN INNOVAX BIOTECH, CO., LTD.Inventors: Shaowei Li, Xinlin Liu, Yurou Yang, Jie Chen, Daning Wang, Ningshao Xia
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Patent number: 11414461Abstract: The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample.Type: GrantFiled: June 3, 2015Date of Patent: August 16, 2022Assignee: THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Robert G. Ulrich, Teddy Kamata
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Patent number: 11235045Abstract: The present disclosure relates to rodent hepadnavirus core antigens including one or more B cell and T cell epitopes of a malaria parasite antigen. More specifically, the present disclosure relates to hybrid woodchuck hepadnavirus core antigens that have been modified to diminish the antibody response to the core antigen so as to enhance the antibody response to fragments of malaria antigen(s) included therein.Type: GrantFiled: October 30, 2018Date of Patent: February 1, 2022Assignee: VLP Biotech, Inc.Inventors: David R. Milich, David C. Whitacre
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Patent number: 11230590Abstract: In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product obtained from an egg-producing animal to an avian. The hyperimmunized egg product may contain an antibody specific to an antigen selected from the group consisting of Clostridium perfringens ?-toxin, Clostridium perfringens elongation factor Tu (EF-Tu), Clostridium perfringens necrotic enteritis B-like (NetB) toxin, Clostridium perfringens Pyruvate: Ferredoxin oxidoreductase (PFO), and Eimeria tenella elongation factor 1-alpha.Type: GrantFiled: September 18, 2019Date of Patent: January 25, 2022Assignees: Arkion Life Sciences, LLC, United States of America, as Represented by the Secretary of AgricultureInventors: Hyun S. Lillehoj, Earnest W. Porta, Samuel V. Walker, Leslie A. Confer, Ujvala Deepthi Gadde, Cyril Gay
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Patent number: 11231720Abstract: A moving robot comprises a floor sensing unit comprised of a plurality of transmitters, for which different sensing distances are set, and a single receiver, and, since a floor state is sensed using a plurality of sensors, it is possible to sense a normal floor states, an obstacle or a cliff present on a floor, and a long-distance state at a distance farther than the normal floor state, thereby preventing wrong sensing of a cliff due to an obstacle, and, since whether to keep traveling is set depending on the obstacle and a traveling speed is controlled, even an area previously not allowed to enter due to the wrong sensing may be cleaned and therefore a cleaning area may be increased.Type: GrantFiled: May 10, 2017Date of Patent: January 25, 2022Assignee: LG ELECTRONICS INC.Inventors: Sihyuk Yi, Jaehwan Ko, Hyukdo Kweon
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Patent number: 11220680Abstract: The present disclosure provides a polypeptide including an anti-fibrin antibody and a serine protease moiety of human tissue plasminogen activator. Methods for treating thrombosis in a subject in need of such treatment using such polypeptide are also disclosed.Type: GrantFiled: November 21, 2019Date of Patent: January 11, 2022Assignee: IMMUNWORK INC.Inventors: Tse-Wen Chang, Hsing-Mao Chu, Wei-Ting Tian, Ting-Wei Chang, Ming-Yu Hsieh
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Patent number: 11124555Abstract: A fusion polypeptide, comprising an inclusion body tag fused to at least one polypeptide of interest, is provided. The inclusion body tag comprises an inclusion body forming (IBF) amino acid sequence selected from X14X15AX17X18X19GLTVA GMLG and sequences having at least 71% identity thereto. Also provided are inclusion bodies comprising the fusion polypeptide, as well as nucleic acids, expression vectors, host cells and methods for its production.Type: GrantFiled: January 29, 2018Date of Patent: September 21, 2021Assignee: ABERA BIOSCIENCE ABInventors: Wouter Simon Petrus Jong, Joen Luirink
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Patent number: 10983121Abstract: Compositions and methods are provided for detection, diagnosis and prognosis of Lyme disease (LD), including a method for confirming Borrelia spp. infection by contacting, in vitro, whole blood samples from subjects suspected of having LD with synthetic peptides comprising T-cell epitope-containing regions derived from Borrelia proteins that are expressed at different stages of Lyme disease, and indirectly detecting LD-specific activated T-cells by determining production of a T-cell immune response indicator (e.g., interferon-Y) in response to stimulation by the peptides.Type: GrantFiled: September 15, 2016Date of Patent: April 20, 2021Assignees: QIAGEN Sciences LLC, Biopeptides Corp., Gundersen Lutheran Medical Foundation, Inc.Inventors: Steven M. Callister, Jeff Boyle, Misato Miyamasu, Raymond Dattwyler, Paul M. Arnaboldi
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Patent number: 10626161Abstract: The present invention provides methods and compositions for optimally co-expressing in a primate subject a tyrosylprotein sulfotransferase (TPST) and a lentiviral gp120-binding molecule to provide potent and long term protection against lentiviral infections.Type: GrantFiled: April 28, 2016Date of Patent: April 21, 2020Assignee: The Scripps Research InstituteInventors: Matthew Gardner, Michael Farzan
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Patent number: 10196089Abstract: A method of controlling a backing system for a vehicle and trailer assembly comprises initiating a backing system mode with an electronic control unit (ECU) for the backing system when a start system input is received from a control device. At least one input is received by the ECU from the control device which includes information about a desired vehicle action. The ECU interprets from the at least one input the desired vehicle action and calculates a required vehicle response to achieve the desired vehicle action. The ECU then sends a request to at least one vehicle system to perform the calculated vehicle response.Type: GrantFiled: October 2, 2015Date of Patent: February 5, 2019Assignee: Continental Automotive Systems, Inc.Inventors: Brandon Herzog, Andre Payant, Jeremy J. McClain, Ibro Muharemovic, Graham Fletcher, Jeffrey Weber, Dominik Froehlich, Steffen Linkenbach, David Agnew
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Patent number: 10125373Abstract: A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.Type: GrantFiled: January 22, 2014Date of Patent: November 13, 2018Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Hugh Mason, Charles Arntzen, Sun Hee Rosenthal, Sean Winkle, Andrew Diamos
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Patent number: 10047149Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).Type: GrantFiled: December 13, 2016Date of Patent: August 14, 2018Assignee: The University of ChicagoInventors: Olaf Schneewind, Dominique M. Missiakas, Hwan Keun Kim, Carla Emolo, Andrea DeDent
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Patent number: 9968668Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.Type: GrantFiled: March 14, 2013Date of Patent: May 15, 2018Assignee: The University of ChicagoInventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
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Patent number: 9963698Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilizes recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or target gene in an organism when introduced thereto are also provided.Type: GrantFiled: December 20, 2013Date of Patent: May 8, 2018Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Michael Wayne Graham, Robert Norman Rice, Peter Michael Waterhouse
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Patent number: 9833511Abstract: This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.Type: GrantFiled: April 23, 2014Date of Patent: December 5, 2017Assignee: Immunomedics, Inc.Inventors: Serengulam V. Govindan, Zhengxing Qu, Hans J. Hansen, David M. Goldenberg
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Patent number: 9821048Abstract: The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ.ID.No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ.ID.No.1, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ.ID.No.1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.Type: GrantFiled: June 24, 2015Date of Patent: November 21, 2017Assignee: IMEVAX GMBHInventors: Markus Gerhard, Christian Schmees, Christian Prinz
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Patent number: 9770517Abstract: Described herein are compositions and methods of use of antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody or antigen-binding fragment thereof, conjugated to one or more cytotoxic drugs. Preferably, the antibody is an RS7, 162-46.2 or MAB650 antibody. More preferably, the antibody is humanized. Preferably the drug is SN-38, pro-2-pyrrolinodoxorubicin, paclitaxel, calichemicin, DM1, DM3, DM4, MMAE, MMAD or MMAF. The compositions and methods are of use to treat Trop-2 expressing cancers, such as breast, ovarian, cervical, endometrial, lung, prostate, colon, stomach, esophageal, bladder, renal, pancreatic, thyroid, epithelial or head-and-neck cancer. Preferably, the cancer is one that is resistant to one or more standard cancer therapies. More preferably, the anti-Trop-2 antibody binds to Trop-2 expressed on normal cells, but administration of the anti-Trop-2 ADC to human cancer patients at a therapeutically effective dosage produces only limited toxicity.Type: GrantFiled: July 1, 2014Date of Patent: September 26, 2017Assignee: Immunomedics, Inc.Inventors: Serengulam V. Govindan, David M. Goldenberg
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Patent number: 9701738Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria, in certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).Type: GrantFiled: March 15, 2013Date of Patent: July 11, 2017Assignee: The University of ChicagoInventors: Molly McAdow, Carla Emolo, Dominique Missiakas, Olaf Schneewind
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Patent number: 9556281Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).Type: GrantFiled: August 15, 2012Date of Patent: January 31, 2017Assignee: The University of ChicagoInventors: Olaf Schneewind, Dominique M. Missiakas, Hwan Keun Kim, Carla Emolo, Andrea DeDent
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Patent number: 9494608Abstract: Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: GrantFiled: August 20, 2013Date of Patent: November 15, 2016Assignee: Janssen Pharmaceutica NVInventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Matthew Garrett Donahue, Yong Gong
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Patent number: 9463227Abstract: This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.Type: GrantFiled: March 12, 2012Date of Patent: October 11, 2016Assignees: ADVAXIS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: John Rothman, Anu Wallecha, Reshma Singh, Donald A. Harn, Jr., Yvonne Paterson
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Patent number: 9402890Abstract: The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.Type: GrantFiled: February 1, 2012Date of Patent: August 2, 2016Assignee: UAB Research FoundationInventors: Ilya Frolov, Elena Frolova
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Patent number: 9295720Abstract: The invention relates to treatment of prostate cancer and metastases thereof. More specifically, the invention relates to immunogenic polypeptides comprising at least a portion of a prostatic tumor cell-associated protein or immunologically active variants thereof and to nucleic acids encoding such polypeptides and to the use thereof in immunotherapeutic methods of treatment of prostate cancer. Said immunogenic polypeptides are provided by the zona pellucida (ZP) (glyco)proteins. ZP (glyco)proteins and fragments thereof that can induce a CD8+ and/or CD4+ T cell response as well as nucleic acid sequences encoding them can suitably be used in the present immunotherapeutic strategies.Type: GrantFiled: August 29, 2011Date of Patent: March 29, 2016Assignee: PANTARHEI BIOSCIENCE B.V.Inventor: Herman Jan Tijmen Coelingh Bennink