Antigens Patents (Class 435/69.3)
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Publication number: 20140178933Abstract: An expression vector which is capable of overexpressing a protein of interest in a host cell, a host cell comprising the expression vector, and a method of producing a protein of interest are provided.Type: ApplicationFiled: April 30, 2012Publication date: June 26, 2014Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, Samsung Electronics Co., Ltd.Inventors: Hyun Min Koo, Byung Jo Yu, Ki Sung Lee, Jae Chan Park, Dae Hyuk Kweon, Sung Minm Park
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Publication number: 20140178419Abstract: The present invention is generally related to virus-like particles (VLPs) comprising rabies virus (RV) glycoproteins (G proteins) and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of rabies virus infection.Type: ApplicationFiled: November 7, 2011Publication date: June 26, 2014Applicant: Novavax, Inc.Inventors: Gale Smith, Ye Liu
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Publication number: 20140178907Abstract: A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: Ortho-Clinical Diagnostics, Inc.Inventors: Jian Zheng, Renee Yura, Jianping Yang
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Patent number: 8759114Abstract: Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.Type: GrantFiled: June 17, 2013Date of Patent: June 24, 2014Assignee: Stichting Voor de Technische WetenschappenInventors: Waltherus Jacobus Wilhelmus Van Venrooij, Jan Wouter Drijfhout, Martinus Adrianus Maria Van Boekel, Gerardus Jozef Maria Pruijn
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Patent number: 8748126Abstract: Induction of tolerance to antigens by mucosal, preferably oral, delivery of the antigen in combination with an immunomodulating compound producing micro-organism is disclosed. More specifically, Foxp3+ and/or IL-10 and/or TGF-? producing regulatory T-cells are induced which are capable of suppressing undesired immune responses toward an antigen. The antigen is preferably delivered orally in combination with an immunosuppressing cytokine secreting micro-organism.Type: GrantFiled: November 29, 2006Date of Patent: June 10, 2014Assignee: Actogenix N.V.Inventors: Pieter Rottiers, Veerle Snoeck
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Publication number: 20140147460Abstract: The present invention relates to a truncated L1 protein of Human Papillomavirus (HPV) Type 33, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein and the virus-like particle are useful for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer. The invention also relates to the use of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer.Type: ApplicationFiled: May 22, 2012Publication date: May 29, 2014Applicants: XIAMEN INNOVAX BIOTECH CO. LTD., XIAMEN UNIVERSITYInventors: Shaowei Li, Xianglin Kong, Minxi Wei, Huirong Pan, Jun Zhang, Ningshao Xia
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Publication number: 20140141029Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicants: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger
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Patent number: 8729231Abstract: The disclosure relates, in some embodiments, to sequences of a novel mutant or variant of the hepatitis B surface antigen (HBsAg) and methods for detecting this genome and protein variant, and antibodies directed against it, from patients' samples.Type: GrantFiled: December 16, 2008Date of Patent: May 20, 2014Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Delia Bussfeld, Anne-Sophie Endres, Helga Meisel, Michael Weik
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Patent number: 8728489Abstract: Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic hepatitis C virus (HCV) infection and related conditions, including liver function. The compositions, kits and uses of the invention, as compared to the use of SOC therapy alone: improves the rate of early response to therapy as measured by early virologic markers (e.g., RVR and EVR), enlarges the pool of patients who will have sustained responses to therapy over the long term, offers shortened courses of therapy for certain patients, enables “rescue” of patients who are non-responders or intolerant to SOC therapy, improves liver function and/or reduces liver damage in patients, and enables the personalization of HCV therapy for a patient, which can result in dose sparing, improved patient compliance, reduced side effects, and improved long term therapeutic outcomes.Type: GrantFiled: September 18, 2009Date of Patent: May 20, 2014Assignee: GlobeImmune, Inc.Inventors: David Apelian, Richard C. Duke, Alex Franzusoff
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Publication number: 20140134202Abstract: An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.Type: ApplicationFiled: December 13, 2011Publication date: May 15, 2014Applicant: FOLIA BIOTECH INC.Inventors: Denis LECLERC, Nathalie MAJEAU, Constantino Roberto LOPEZ-MACIAS, III, Alain LAMARRE
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Publication number: 20140127266Abstract: Disclosed herein are methods of making a vaccine against Entamoeba histolytica and methods of immunizing a subject using such vaccine.Type: ApplicationFiled: December 17, 2012Publication date: May 8, 2014Applicant: University of Central Florida Research Foundation, Inc.Inventor: Henry Daniell
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Publication number: 20140127216Abstract: An expression cassette, wherein said expression cassette comprises: (a) an ie 1 promoter from white spot syndrome virus or a variant thereof; (b) a nucleic acid sequence encoding an N-terminal gp64 signal peptide or variant thereof, a nucleic acid sequence encoding an antigenic peptide, a nucleic acid encoding a transmembrane region, and a nucleic acid encoding a gp64 cytoplasmic region or variant thereof; in which the promoter is operably linked to the nucleic acid sequence.Type: ApplicationFiled: February 8, 2012Publication date: May 8, 2014Applicant: Temasek Life Sciences Laboratory LimitedInventors: Premanand Balraj, Hwei-Sing Jimmy Kwang, Anbu Kumar Karuppannan
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Patent number: 8715695Abstract: The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention.Type: GrantFiled: September 11, 2009Date of Patent: May 6, 2014Assignees: Beijing Wantai Biological Pharmacy Enterprise Co., Ltd., Xiamen UniversityInventors: Ningshao Xia, Jun Zhang, Shaowei Li, Shengxiang Ge, Ying Gu, Zhiqiang He
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Publication number: 20140120128Abstract: An antigenic composition comprising an antigen and an effective adjuvant, the adjuvant comprising isolated or recombinant YscF, a YscF fragment, truncated YscF (trYscF), or homologs thereof. A method of inducing an enhanced immune response comprising administering an antigen and an effective adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. An antigenic composition produced by a process comprising providing a host cell with an expression vector containing a nucleotide sequence encoding YscF, a YscF fragment, trYscF, or YscF homolog capable of acting as an adjuvant; expressing the nucleotide sequence in the host cell to produce the protein; and mixing the collected protein with a suitable excipient.Type: ApplicationFiled: June 22, 2012Publication date: May 1, 2014Inventor: Matthew Nilles
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Publication number: 20140112923Abstract: Disclosed are an epitope specific to hepatitis B virus (HBV) and use thereof. The disclosed epitope is a conservative position on which mutagenesis does not occur and, therefore, a composition including an antibody to the foregoing epitope or a vaccine composition including the epitope has very low possibility of causing degradation of curing efficacy due to HBV mutation, thus being very useful for HBV treatment.Type: ApplicationFiled: July 25, 2011Publication date: April 24, 2014Applicant: GREEN CROSS CORPORATIONInventors: Se-Ho Kim, Kwang-Won Hong, Yong-Won Shin, Ki Hwan Chang, Min-Soo Kim, Jung-Ae Im
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Publication number: 20140112954Abstract: The present invention discloses a method for preparing HBV Vaccine comprising aluminum adjuvant, which belongs to biological technology field. The method, which is characterized in that aluminum adjuvant Al(OH)3 is produced by an on-line reaction, comprises mixing PBS buffer solution and potassium aluminum sulfate (KAl(SO4)2) solution with hepatitis B surface antigen stock solution, adding sodium hydroxide (NaOH) solution into the mixed solution, so that the adjuvant is continuously produced and hepatitis B surface antigens are continuously coated and absorbed simultaneously. The process is called “in-situ adsorption”.Type: ApplicationFiled: April 18, 2012Publication date: April 24, 2014Applicant: DALIAN HISSEN BIO-PHARM CO., LTD.Inventors: Guixing Li, Ping Zhang, Haichun Zhang, Xinting Chen, Xiaoyu Li, Juan Zhang, Caixia Su
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Publication number: 20140106398Abstract: The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest.Type: ApplicationFiled: March 12, 2012Publication date: April 17, 2014Applicant: DSM IP ASSETS B.V.Inventors: Roelof Ary Lans Bovenberg, Jan Andries Kornelis Willem Kiel, Thibaut José Wenzel, Alrik Pieter Los
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Publication number: 20140099334Abstract: The invention relates to epitopes of SEMA4D and to binding agents, such as antibodies, that specifically bind to SEMA4D.Type: ApplicationFiled: March 14, 2013Publication date: April 10, 2014Applicant: VACCINEX, INC.Inventor: VACCINEX, INC.
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Publication number: 20140099338Abstract: The present invention provides a recombinant yeast system for expressing the glycoprotein E2 of classical swine fever virus (CSFV), in which the expression level of yE2 is improved by codon optimization and shortening coding region of E2 gene. The truncated E2 subunits are used as major active ingredient in anti-CSFV vaccines and useful diagnostic blocking ELISA kits for CSFV infection with easy manipulation and low cost.Type: ApplicationFiled: December 14, 2013Publication date: April 10, 2014Applicant: Mao-Xing Biological Technology Co., Ltd.Inventors: Chienjin Huang, Maw-Sheng Chien, Guang-Jan Lin
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Publication number: 20140093540Abstract: Immunogenic compositions and vaccines against Plasmodial infection comprising an Rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are Rh5 polypeptides or fragments or variants thereof capable of binding CD147 and conferring protection against infection and/or disease caused by multiple Plasmodial strains or Plasmodial species, inhibitors of the interaction between Rh5 and CD147 and methods for producing polypeptides in a mammalian expression system.Type: ApplicationFiled: October 7, 2011Publication date: April 3, 2014Applicant: Genome Research LimitedInventors: Gavin J. Wright, Julian C. Rayner, Cecile Crosner, Leyla Y. Bustamante, S. Josefin Bartholdson
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Publication number: 20140093556Abstract: The disclosure relates to immunological compositions for vaccinating human beings against infection by the Human Immunodeficiency Virus (HIV).Type: ApplicationFiled: January 26, 2012Publication date: April 3, 2014Applicants: SANOFI PASTEUR SA, POLYMUNE SCIENTIFIC IMMUNOBIOLOGISCHE FORSCHUNG GMBH, UNIVERSIDAD DE GRANADA, PX' THERAPEUTICSInventors: Francisco Conejero-Lara, Irene Luque, Pedro Luis Mateo, Andreas Wagner, Raphaelle Claude, Marie-Gaelle Roger, Nicolas Mouz, Christophe Martin
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Publication number: 20140093530Abstract: The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of K1-type Plasmodium falciparum merozite surface antigen (MSP1) and fusion proteins containing that sequence in combination with additional epitope-containing sequences capable of inducing antibody and cellular immune responses to P.Type: ApplicationFiled: October 9, 2013Publication date: April 3, 2014Inventors: Kevin TETTEH, David Conway
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Publication number: 20140086943Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.Type: ApplicationFiled: March 15, 2013Publication date: March 27, 2014Applicant: IMMATICS BIOTECHNOLOGIES GMBHInventors: Toni WEINSCHENK, Peter LEWANDROWSKI, Oliver SCHOOR
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Publication number: 20140080997Abstract: A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following recombinant protein (a) or (b) is provided: (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2 or 35; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 35 by deletion, substitution, or addition of one or several amino acids and having mite allergen activity.Type: ApplicationFiled: October 14, 2013Publication date: March 20, 2014Applicant: NIPPON ZENYAKU KOGYO CO., LTD.Inventors: Toshihiro TSUKUI, Hajime TSUJIMOTO, Shigehiro IWABUCHI
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Publication number: 20140079709Abstract: The present invention provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.Type: ApplicationFiled: February 6, 2012Publication date: March 20, 2014Applicant: Integrated Bio Therapeutics Inc.Inventors: Mohammad Javad Aman, Rajan Prasad Adhikari, Hatice Karauzum, Kelly Lyn Warfield, Tam Luong Nguyen
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Publication number: 20140072556Abstract: Disclosed are novel immunogenic proteins derived from Staphylococcus aureus, as well as methods for their use in conferring protective immunity against S. aureus infections. Also disclosed are nucleic acid encoding the proteins and methods of use of these nucleic acids.Type: ApplicationFiled: April 3, 2012Publication date: March 13, 2014Applicant: Nov Vac APSInventors: Niels Iversen Møller, Andreas Mattsson
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Publication number: 20140065180Abstract: The invention provides virus-like particles (VLP) highly secreting or producing signal peptide obtained by altering a signal sequence derived from West Nile virus (WNV), the signal peptide, a WNV VLP secretion expression vector containing a nucleic acid encoding prM protein and E protein, a WNP VLP highly secreting or producing animal cell line harboring the vector, a WNV vaccine containing WNV VLP obtained by the cell line as an active ingredient, and a WNV DNA vaccine containing the VLP secretion expression vector as an active ingredient.Type: ApplicationFiled: November 4, 2013Publication date: March 6, 2014Applicants: The Research Foundation for Microbial Diseases of Osaka University, Japan as Represented by the Director-General of National Inst. of Infectious DiseasesInventors: Asato KOJIMA, Hidehiro TAKAHASHI, Toyokazu ISHIKAWA
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Patent number: 8663943Abstract: In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.Type: GrantFiled: July 14, 2008Date of Patent: March 4, 2014Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Jian Zheng, Steve Stanley Alexander
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Publication number: 20140051093Abstract: The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from a bacterial host.Type: ApplicationFiled: July 26, 2013Publication date: February 20, 2014Applicant: Pfenex Inc.Inventors: Diane M. Retallack, Lawrence Chew
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Publication number: 20140050755Abstract: The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals.Type: ApplicationFiled: October 23, 2013Publication date: February 20, 2014Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.Inventors: Eric Martin VAUGHN, Paulino Carlos GONZALEZ-HERNANDEZ, Juergen DAEMMGEN
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Publication number: 20140050758Abstract: The present invention provides a process for periplasmic expression of a bacterial toxoid comprising the steps of: a), growing a culture of a gram negative host cell in a fermentation medium, wherein the host cell is transformed with a polynucleotide, and wherein the polynucleotide encodes the bacterial toxoid and a periplasmic signal sequence; or providing a gram negative host cell wherein the host cell is transformed with a polynucleotide, the polynucleotide encodes the bacterial toxoid and a periplasmic signal sequence and wherein the gram negative host cell comprises the bacterial toxoid expressed in the periplasm; a(i)) inducing expression of the bacterial toxoid; b) maturing the host ceil, wherein the maturing step comprises; I) subjecting the host cell to a pH shock; II) incubating the host ceil with no feed addition; and/or III) subjecting the host ceil to a temperature below ?20° C.; and c) extracting the bacterial toxoid from the host cell wherein the extraction process comprises osmotic shock.Type: ApplicationFiled: April 12, 2012Publication date: February 20, 2014Applicant: GLAXOSMITHKLINE BIOLOGICALS, S.A.Inventors: Philippe Marc Helene Dohottay, Philippe Goffin
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Patent number: 8653234Abstract: The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPH1 and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines.Type: GrantFiled: June 27, 2012Date of Patent: February 18, 2014Assignee: OncoTherapy Science, Inc.Inventors: Tomoaki Fujioka, Yusuke Nakamura, Takuya Tsunoda, Ryuji Osawa, Midori Shida
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Publication number: 20140037665Abstract: The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.Type: ApplicationFiled: September 25, 2013Publication date: February 6, 2014Inventors: Melinda Jane Frost, Peter Daniel Kirkland, Deborah Susan Finlaison
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Publication number: 20140037679Abstract: The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human adenovirus vectors for delivery of avian immunogens and antigens, such as avian influenza into avians. The invention also provides methods of introducing and expressing an avian immunogen in avian subjects, including avian embryos, as well as methods of eliciting an immunogenic response in avian subjects to avian immunogens.Type: ApplicationFiled: September 6, 2013Publication date: February 6, 2014Inventors: De-Chu C. Tang, Kent R. Van Kampen, Harold Toro
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Publication number: 20140030287Abstract: The present invention relates to peptides of the enolase protein from Staphylococcus aureus as well as nucleic acid and nucleic acid sequence homologues encoding the peptides. The present invention also relates to a composition, particularly a S. aureus vaccine, comprising one or more of the enolase peptides described herein or a fragment, derivative or variant thereof capable of generating an immune response that induces a protective antibody response or opsonophagocytic activity of human neutrophils for S. aureus. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition of the invention.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Inventors: TESSIE B. MCNEELY, LESLIE COPE, SHARON SMITH, AMITA JOSHI, IRENE PAK, ARTHUR FRIDMAN
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Publication number: 20140030285Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.Type: ApplicationFiled: July 17, 2013Publication date: January 30, 2014Applicants: Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, University of RochesterInventors: Benjamin J. Luft, John J. Dunn, Shohei Koide, Catherine L. Lawson
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Publication number: 20140017727Abstract: The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.Type: ApplicationFiled: June 7, 2013Publication date: January 16, 2014Inventors: Andrea Guido Oreste Manetti, Immaculada Margarit Y Ros, Guido Grandi
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Publication number: 20140017274Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.Type: ApplicationFiled: March 23, 2012Publication date: January 16, 2014Applicant: Immunobiology LimitedInventors: Camilo Colaco, Ian Mcentee
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Patent number: 8629260Abstract: The present disclosure provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present disclosure also provides compositions for vaccines to prevent Leishmaniasis.Type: GrantFiled: December 11, 2012Date of Patent: January 14, 2014Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M.C. Ribeiro
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Publication number: 20140011188Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.Type: ApplicationFiled: November 4, 2011Publication date: January 9, 2014Applicant: Academia SinicaInventors: Chi-Huey Wong, Che Ma, Yung-Chieh Tseng
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Publication number: 20140004135Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.Type: ApplicationFiled: March 14, 2013Publication date: January 2, 2014Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, GLOBEIMMUNE, INC.Inventors: GLOBEIMMUNE, INC., The United States of America, as represented by the Secretary, Department of Health and Human Services
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Publication number: 20140004146Abstract: The present invention relates to methods and applications of using Drosophila cells to produce virus-like particles. Virus-like particles of enveloped viruses produced by the methods of the present invention have proteins correctly expressed, cleaved, and assembled. Ultimately, virus-like particles having good immunogenicity are obtained. The present invention also provides recombinant cells expressing virus-like particles and compositions containing virus-like particles.Type: ApplicationFiled: March 19, 2012Publication date: January 2, 2014Applicant: INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCESInventors: Paul Zhou, Yufeng Song, Fan Zhou, Lifei Yang, Cheguo Cai, Heng Ding
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Publication number: 20130347146Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.Type: ApplicationFiled: June 19, 2013Publication date: December 26, 2013Applicant: Stichting Dienst Landbouwkundig OnderzoekInventors: Hendrikus Antonius Cornelis Bakker, Dionisius Elisabeth Antonius Florack, Hendrik Jan Bosch
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Publication number: 20130345398Abstract: The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product is stable and proteolytically active. Methods of using the products of the invention are described.Type: ApplicationFiled: March 23, 2012Publication date: December 26, 2013Inventors: Leonard A Smith, Melody Jensen
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Publication number: 20130336971Abstract: The present disclosure relates to recombinant fusion proteins, such as human antibody-based molecules called Vaccibodies, which are able to trigger both a T cell- and B cell immune response. The present disclosure also relates to a method of treating a cancer or an infectious disease by means of these specific fusion proteins.Type: ApplicationFiled: June 24, 2011Publication date: December 19, 2013Applicant: VACCIBODY ASInventors: Pier Adelchi Ruffini, Bjarne Bogen, Agnete Brunsvik Fredriksen
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Patent number: 8609402Abstract: The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Further described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.Type: GrantFiled: May 31, 2011Date of Patent: December 17, 2013Assignees: Aeras Global TB Vaccine Foundation, Crucell Holland B.VInventors: Menzo Jans Emco Havenga, Ronald Vogels, Jerald C. Sadoff, David Hone, Yasir Abdul Wahid Skeiky, Katarina Rado{hacek over (s)}evic
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Publication number: 20130330338Abstract: The present disclosure relates to CTLA4 proteins and uses of such proteins, for example to treat diseases associated with the dysregulation of immune responses.Type: ApplicationFiled: August 15, 2013Publication date: December 12, 2013Applicant: AbbVie Biotherapeutics Inc.Inventors: Yoshiko AKAMATSU, Veronica Juan, Robert B. Dubridge
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Publication number: 20130323272Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.Type: ApplicationFiled: June 28, 2013Publication date: December 5, 2013Applicant: IMMATICS BIOTECHNOLOGIES GMBHInventors: Hans Georg Rammensee, Stefan Stevanovic, Cecile Gouttefanges, Toni Weinschenk, Peter Lewandrowski
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Publication number: 20130324593Abstract: The present invention relates to a hybrid promoter, in which a whole or a part of a CMV enhancer, a whole or a part of a ?-actin promoter, a whole or a part of a CMV promoter, and a whole or a part of a ?-actin intron are operably linked to each other, a recombinant vector comprising the same, a transformant transformed with the recombinant vector, a pharmaceutical composition comprising the recombinant vector or the transformant, and a method for preparing a target protein using the recombinant vector or the transformant. The hybrid promoter of the present invention is able to induce high expression of a target protein in a eukaryotic cell. Therefore, the hybrid promoter of the present invention can be effectively used for the development of an antibody or the production of a DNA vaccine.Type: ApplicationFiled: November 29, 2011Publication date: December 5, 2013Applicant: LG Life Sciences LtdInventors: Yeon Chul Kim, Saem Jung, Jun Jung
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Publication number: 20130315943Abstract: Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.Type: ApplicationFiled: July 15, 2011Publication date: November 28, 2013Inventors: Shaowei Li, Minxi Wei, Xianglin Kong, Yingbin Wang, Jun Zhang, Ningshao Xia