Having A Fused Ring Containing A Six-membered Ring Having Two N-atoms In The Same Ring (e.g., Purine Nucleosides, Etc.) Patents (Class 435/88)
-
Patent number: 5306629Abstract: A method for producing a dinucleoside polyphosphate, a nucleoside polyphosphate or a derivative thereof which comprises using adenosine-5'-triphosphate, polyphosphate or a derivative thereof and a sulfate as reaction substrates and forming a dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof via a two-stage reaction through the use of two enzymes, namely, adenosine-5'-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts.Type: GrantFiled: April 15, 1993Date of Patent: April 26, 1994Assignee: Unitika Ltd.Inventors: Hideki Yamamoto, Mika Manabe, Hiroshi Nakajima
-
Patent number: 5258301Abstract: The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby forming an N-glycosidic bond between the base moiety of the base donor and the saccharide moiety of the saccharide residue donor, which comprises using, as the enzyme preparation containing nucleoside phosphorylase, a preparation derived from the cells of one or more kinds of microorganisms belonging to thermophiles of the genus Bacillus and having high nucleoside phosphorylase activity per unit cell weight.Type: GrantFiled: October 26, 1990Date of Patent: November 2, 1993Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Hiroshi Yamauchi, Hideki Utsugi, Yuichiro Midorikawa
-
Patent number: 5234685Abstract: There is disclosed a method of determining the presence of incompatibility-reaction-causing substances in blood products. There is also disclosed a method of inactivating incompatibility-reaction-causing substances in blood products to be applied therapeutically and prophylactically. For this purpose, a fraction obtained from human or animal blood is treated with pancreas enzymes bound to water insoluble carrier material and, optionally, the fraction is subjected to further fractionation and concentration.Type: GrantFiled: September 26, 1989Date of Patent: August 10, 1993Assignee: Immuno Aktiengesellschaft fur chemisch-medizinische ProdukteInventors: Johann Eibl, Yendra Linnau, Otto Schwarz
-
Patent number: 5214048Abstract: This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.Type: GrantFiled: November 20, 1989Date of Patent: May 25, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takayuki Tomizawa, Seiichi Saito, Kyoichi Shibuya, Akio Fujii, Hiroo Hoshino, Kenichi Matsubara, Takemitsu Nagahata, Katsutoshi Takahashi, Yukihiro Nishiyama
-
Patent number: 5204245Abstract: An enzymatic process for extracting a nucleoside, such as thymidine, from a biomass without substantial thymine production.Type: GrantFiled: May 15, 1991Date of Patent: April 20, 1993Assignee: E. I. du Pont de Nemours and CompanyInventors: James A. Doncheck, James R. Millis, Paul E. Swanson
-
Patent number: 5164306Abstract: A process for producing 5'-inosinic acid by culturing 5'-inosinic acid-producing bacteria in a medium containing inosine, and cane molasses, sucrose or glucose as the main carbon source and containing at least one of L-methylglycine, N,N-dimethylglycine, N,N,N-trimethylglycine and (2-hydroxyethyl)trimethylammonium in an amount effective to enhance the yield of 5'-inosinic acid, and harvesting the 5'-inosinic acid produced.Type: GrantFiled: January 31, 1990Date of Patent: November 17, 1992Assignee: Ajinomoto Co., Inc.Inventors: Yasuhiko Yoshihara, Yoshio Kawahara, Yasutsugu Yamada, Sigeho Ikeda
-
Patent number: 5149640Abstract: A galactose transfer product is prepared by a process of allowing a microorganism capable of producing a galactose transfer product of the formula: (Gal).sub.n --R, wherein Gal represents a galactose residue, n represents an integer of 1 to 4 and R represents a galactose receptor to act on a combination of lactose or a galactose donor and a galactose receptor; and collecting the galactose transfer product produced.Type: GrantFiled: December 22, 1989Date of Patent: September 22, 1992Assignee: Ajinomoto Co., Inc.Inventors: Norimasa Oonishi, Kenzo Yokozeki
-
Patent number: 5120645Abstract: A process for the preparation of 2-deoxyuridine, which can be used as a nucleus for compositions useful as therapeutic drugs, in which a strain of the genus Brevibacterium is cultivated on a suitable nutrient medium, e.g. containing glucose as a carbon source. Preferred Brevibacterium strains are strains of Brevibacterium helvolum in particular strains NCIMB 40117 and NCIMB 40116 which 2 strains are claimed per se.Type: GrantFiled: March 16, 1990Date of Patent: June 9, 1992Assignee: Imperial Chemical Industries PLCInventor: Linda A. Naylor
-
Patent number: 5116741Abstract: The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.Type: GrantFiled: January 26, 1989Date of Patent: May 26, 1992Assignee: Genex CorporationInventors: Philip N. Bryan, Michael W. Pantoliano, Michele L. Rollence, Chi H. Wong
-
Patent number: 5075225Abstract: A process for synthesizing nucleosides is disclosed. The process includes the reaction of an alkylated nucleoside (such as 7-methylguanosine or 7-methylinosine) with a heterocyclic base (such as adenine, 3-deazaadenine or 1,2,4-triazole-3-carboxamide) in the presence of a nucleoside-forming enzyme to form a nucleoside that includes a glycosyl component, donate by the alkylated nucleoside, bonded to the heterocyclic base.Type: GrantFiled: April 6, 1989Date of Patent: December 24, 1991Assignee: The Texas A&M University SystemInventors: Chi-Huey Wong, William J. Hennen
-
Patent number: 5053499Abstract: 2', 3'-Dideoxy purine nucleosides represented by following general formulae [I] and/or [II] ##STR1## (wherein X and Y indicate nitrogen atoms or carbon atoms and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 indicate each independently any of hydrogen atom, hydroxyl group, amino group, alkyl group, halogen atom, alkoxy group and mercapto group), process for the preparation thereof and applications thereof to the antiviral agent, antiretroviral agent, therapeutic drug and preventive drug for acquired immunodeficiency syndrome (AIDS), and experimental medicine and experimental reagent to be used in genetic engineering are claimed.Type: GrantFiled: August 3, 1989Date of Patent: October 1, 1991Assignee: Sanyo-Kokusaku Pulp Co., Ltd.Inventors: Eiji Kojima, Hidetoshi Yoshioka, Hidenori Fukinbara, Kunichika Murakami
-
Patent number: 5011774Abstract: A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.Type: GrantFiled: February 28, 1990Date of Patent: April 30, 1991Assignee: Bristol-Myers Squibb Co.Inventors: Vittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
-
Patent number: 5008188Abstract: Process for producing S-adenosyl-L-homocysteine, which comprises reacting adenosine with homocysteine by contacting them in an aqueous medium in the presence of cells or treated cells of a microorganism of a specified genus having the ability to synthesize S-adenosyl-L-homocysteine from adenosine and homocysteine, and collecting the S-adenosyl-L-homocysteine synthesized.Type: GrantFiled: November 4, 1987Date of Patent: April 16, 1991Assignee: Nippon Zeon Co., Ltd.Inventors: Hideaki Yamada, Yoshiki Tani, Sakayu Shimizu, Shozo Shiozaki
-
Patent number: 4992368Abstract: The present invention provides a novel process for producing oxetanocin G by hydrolysis of alkoxylated 2-amino-oxetanocin A thereby to convert ##STR1## at the 6-position thereof into >C.dbd.O. Oxetanocin G is expectedly useful as an antiviral agent.Type: GrantFiled: April 12, 1990Date of Patent: February 12, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Noriyuki Yamashita
-
Patent number: 4970148Abstract: A method of producing dideoxyinosine involving contacting as a substrate 2',3'-dideoxyadenosine with a microorganism which is capable of converting the substrate into 2',3'-dideoxyinosine.Type: GrantFiled: October 7, 1988Date of Patent: November 13, 1990Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Hideyuki Shirae, Katsunori Kobayashi, Hiroshi Shiragami, Yasuo Irie
-
Patent number: 4960696Abstract: A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. is disclosed. In addition, there is disclosed a process for producing a physiologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) synthesizing a physiologically active substance with the resulting ATP, converting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period of time.Type: GrantFiled: June 6, 1988Date of Patent: October 2, 1990Assignees: Kazutomo Imahori, Rikagaku Kenkyusho, Unitika Ltd.Inventors: Kazutomo Imahori, Hitoshi Kondo, Hiroshi Nakajima, Tatsuo Iwasaki
-
Patent number: 4923851Abstract: A composition of matter for increasing the intracellular synthesis of ATP. The composition consists of amino acids, metabolites, electrolyte and a pentose sugar. When applied to wounds, the invention increases the rate of wound repair. When administered orally, the invention increases ATP blood levels and physical performance levels.Type: GrantFiled: October 2, 1989Date of Patent: May 8, 1990Assignee: Raymond A. RoncariInventor: Francis J. Carniglia
-
Patent number: 4914028Abstract: A process for preparing .beta.-2',2'-difluoronucleosides, and a novel intermediate thereto, are disclosed.Type: GrantFiled: February 10, 1988Date of Patent: April 3, 1990Assignee: Eli Lilly and CompanyInventors: Larry W. Hertel, Cora Sue Grossman, Julian S. Kroin
-
Patent number: 4904585Abstract: This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineo-plastic activities and is expected as a pharmaceutical as well as a process for the production of the same.Type: GrantFiled: November 2, 1987Date of Patent: February 27, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takashi Harada, Takayuki Tomizawa, Akio Fujii
-
Patent number: 4882276Abstract: A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50.degree. C. to 85.degree. C. and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50.degree. to 85.degree. C. is disclosed. In addition, there is disclosed a process for producing a physiologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) synthesizing a physiologically active substance with the resulting ATP, coverting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period of time.Type: GrantFiled: January 26, 1983Date of Patent: November 21, 1989Assignees: Kazutomo Imahori, Rikagaku Kenkyusho, Unitika Ltd.Inventors: Kazutomo Imahori, Hitoshi Kondo, Hiroshi Nakajima, Tatsuo Iwasaki
-
Patent number: 4835104Abstract: A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.Type: GrantFiled: May 9, 1988Date of Patent: May 30, 1989Assignee: Ajinomoto Co., Inc., Patent & Licensing DepartmentInventors: Kenzo Yokozeki, Hideyuki Shirae, Hiroshi Shiragami, Yasuo Irie, Naohiko Yasuda, Masaru Otani, Toshiya Tanabe
-
Patent number: 4749650Abstract: A DNA having a 5'-inosinate dehydrogenase gene and further having a Hind III cleavage site 2.9 kilo base pairs can be produced from the chromosomal DNA of a guanosine and/or xanthosine-producing strain of the genus Bacillus. A vector with the DNA obtained above is used to transform Bacillus strain capable of producing guanosine, and the transformed Bacillus strain is useful to increase the guanosine productivity as compared with the case in which a strain before transformantion is used.Type: GrantFiled: November 14, 1984Date of Patent: June 7, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Miyagawa Kenichiro, Nakahama Kazuo, Kikuchi Masakazu, Doi Muneharu
-
Patent number: 4743689Abstract: This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineoplastic activities and is expected as a pharmaceutical as well as a process for the production of the same.Type: GrantFiled: November 8, 1985Date of Patent: May 10, 1988Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takashi Harada, Takayuki Tomizawa, Akio Fujii
-
Patent number: 4701413Abstract: Method of producing inosine and/or guanosine by culturing an inosine and/or guanosine-producing mutant of the genus Bacillus which requires adenine for growth and is resistant to an antifolate. Thus, inosine and/or guanosine can be produced in much greater yields, compared with known methods.Type: GrantFiled: July 19, 1983Date of Patent: October 20, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Kenichiro Miyagawa, Muneharu Doi, Shun-ichi Akiyama
-
Patent number: 4605625Abstract: S-adenosyl-L-homocysteine is produced by contacting adenosine with D-homocysteine in an aqueous medium in the presence of cells or treated cells of a microorganism of the genus Pseudomonas having the ability to racemize D-homocysteine to DL-homocysteine and in the presence of S-adenosyl-L-homocysteine hydrolase, to synthesize S-adenosyl-L-homocysteine, and thereafter collecting it.Type: GrantFiled: February 27, 1985Date of Patent: August 12, 1986Assignee: Nippon Zeon Co., Ltd.Inventors: Hideaki Yamada, Sakayu Shimizu, Shozo Shiozaki
-
Patent number: 4594320Abstract: Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of microorganism origin is disclosed. The nucleoside phosphorylase source is specified.Type: GrantFiled: March 29, 1983Date of Patent: June 10, 1986Assignee: Yamasa Shoyu Kabushiki KaishaInventor: Tetsuro Fujishima
-
Patent number: 4594321Abstract: Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of microorganism origin is disclosed.Type: GrantFiled: March 29, 1983Date of Patent: June 10, 1986Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Tetsuro Fujishima, Shinji Sakata
-
Patent number: 4593000Abstract: A method of producing guanosine using an adenine-requiring microorganism, in which method the amount of the adenine-containing material to be added to the initial medium is restricted to not more than 50% of the required amount and, after the adenine-containing material added to the initial medium has been consumed almost completely, the remainder of the required amount is added intermittently or continuously.Type: GrantFiled: January 7, 1985Date of Patent: June 3, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasuhiro Sumino, Koji Sonoi, Muneharu Doi
-
Patent number: 4578336Abstract: In a fermentation procedure for the production of nucleosides i.e. inosine and/or guanosine using an adenine-requiring microorganism, the fermentation is carried out by allowing a source of adenine to be present in the medium in an excess amount over the amount of adenine that would be conductive to a maximum yield of inosine and/or guanosine in aerobic culture using ordinary air, and cultivating the microorganism while an oxygen-rich gas is bubbled into the medium. Thus, inosine and/or guanosine are accumulated in high yield in the fermentation broth.Type: GrantFiled: November 24, 1982Date of Patent: March 25, 1986Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasuhiro Sumino, Koji Sonoi, Muneharu Doi
-
Patent number: 4565781Abstract: An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the antibiotic, Spicamycin.(1) Color and properties: Weakly acidic white powder(2) Melting point: 215.degree. to 220.degree. C. (decomposed)(3) Specific rotatory power: [.alpha.].sub.D.sup.25 =+15.degree. (C: 0.15, in methanol)(4) Elementary analysis (Found): C: 57.4%, H: 8.3%; N: 15.7%, O: 18.6%(5) Ultraviolet absorption spectrum (maximum):______________________________________ CH.sub.3 OH 264 nm (E.sub.1cm.sup.1% 257) 0.01N NaOH + CH.sub.3 OH 272 nm (E.sub.1cm.sup.1% 226) 0.01N HCl + CH.sub.3 OH 273 nm (E.sub.1cm.sup.1% 258) ______________________________________(6) Infrared absorption spectrum (as measured by the potassium bromide method): As shown in FIG. 2.(7) Solubility in Solvent: Soluble in basic water, dimethyl sulfoxide, methanol, ethanol, n-propanol, and n-butanol.Type: GrantFiled: February 24, 1984Date of Patent: January 21, 1986Assignee: Kirin Beer Kabushiki KaishaInventors: Noboru Otake, Yoichi Hayakawa, Hiroyuki Kawai, Masaya Nakagawa, Kozo Tanabe, Junichiro Mochizuki
-
Patent number: 4562149Abstract: A yeast culture containing at least 10% by weight, based on the dry cell, of S-adenosyl methionine; and a process for producing S-adenosyl methionine, which comprises cultivating a yeast having the ability to produce S-adenosyl methionine in a liquid culture medium containing methionine to accumulate at least 10% by weight, based on the dry yeast cells, of S-adenosyl methionine in the yeast cells, separating the yeast cells from the culture medium, and thereafter obtaining S-adenosyl methionine in a stable form from the yeast cells.Type: GrantFiled: February 4, 1983Date of Patent: December 31, 1985Assignee: Nippon Zeon Co., Ltd.Inventors: Shozo Shiozaki, Hideaki Yamada, Yoshiki Tani, Sakayu Shimizu
-
Patent number: 4483964Abstract: A reactor system and method for synthesizing or degrading polynucleotides and other linear polymers includes a tubular reactor connected to a reagent manifold. The polynucleotide is immobilized on a loosely packed solid-phase support material in the tubular reactor, and reagents are sequentially introduced into the tubular reactor. After each reagent is introduced, the tubular reactor is isolated from the reagent manifold and the reagent agitated by alternately pressurizing the opposite ends of the tubular reactor. The method provides rapid and efficient synthesis of polynucleotides.Type: GrantFiled: June 20, 1983Date of Patent: November 20, 1984Assignee: Chiron CorporationInventors: Mickey S. Urdea, Brian D. Warner
-
Patent number: 4460765Abstract: A new compound, named "Griseolic acid", and its salts and can be prepared by the cultivation of Streptomyces griseoaurantiacus SANK 63479 (FERM-P 5223). Griseolic acid and its salts inhibit the activity of the enzyme cyclic adenosine monophosphate phosphodiesterase and, as a result of this, have variety of physiological activities and uses.Type: GrantFiled: May 12, 1982Date of Patent: July 17, 1984Assignee: Sankyo Company LimitedInventors: Atsushi Naito, Fumio Nakagawa, Takao Okazaki, Akira Terahara, Seigo Iwado, Mitsuo Yamazaki
-
Patent number: 4452889Abstract: A method of producing inosine and/or guanosine comprising cultivating a microorganism in a medium containing a carbohydrate, in which method a carbohydrate is added either continuously or intermittently to the medium when and in the state that the concentration of the carbohydrate in the medium is less than about 1 percent so that the carbohydrate concentration of the medium is maintained below about 1 percent.Type: GrantFiled: June 17, 1982Date of Patent: June 5, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Koji Sonoi, Yasuhiro Sumino, Muneharu Doi
-
Patent number: 4394446Abstract: The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.Type: GrantFiled: November 20, 1981Date of Patent: July 19, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi
-
Patent number: 4381344Abstract: The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed reaction of the appropriately substituted 3-deazapurine with a 2'-deoxyribose donor.Type: GrantFiled: April 25, 1980Date of Patent: April 26, 1983Assignee: Burroughs Wellcome Co.Inventors: Janet L. Rideout, Thomas A. Krenitsky
-
Patent number: 4371613Abstract: Purine-arabinosides and a method for making purine-arabinosides are disclosed. The method comprises contacting an arabinose donor and a purine source in the presence of an effective amount of enzyme produced by a bacterium and capable of transarabinosylation from the arabinose donor to the purine source, whereby a 9-(.beta.-D-arabinofuranosyl)-purine is produced.Type: GrantFiled: August 1, 1978Date of Patent: February 1, 1983Assignee: Ajinomoto Company IncorporatedInventors: Takashi Utagawa, Takeshi Miyoshi, Hirokazu Morisawa, Akihiro Yamazaki, Fumihiro Yoshinaga, Koji Mitsugi
-
Patent number: 4347315Abstract: 4-Substituted-3-deazapurine ribosides are prepared by the enzymatically catalyzed reaction of 4-substituted-3-deazapurine with a ribose donor.Type: GrantFiled: April 25, 1980Date of Patent: August 31, 1982Assignee: Burroughs Wellcome Co.Inventors: Thomas A. Krenitsky, Janet L. Rideout
-
Patent number: 4316957Abstract: The antibacterial compounds 7-deazaadenosine and 7-deazinosine are produced by fermentation of a new microorganism of the genus Micromonospora. At least one of the active substances is isolated from the culture medium.Type: GrantFiled: April 4, 1978Date of Patent: February 23, 1982Assignee: Abbott LaboratoriesInventors: Takashi Nara, Ryo Okachi, Isao Kawamoto, Tomoyasu Sato, Tetsuo Oka
-
Patent number: 4299823Abstract: 4-Substituted alkyl-1-.alpha.-D-ribofuransylpyrazole-(3,4-d) pyrimidines are active against coccidia in vivo and unlike the 4-methylthio analogue, are non-toxic. Methods for preparing and using the compounds, intermediates in the preparation and compositions of the compounds are also described.Type: GrantFiled: June 13, 1980Date of Patent: November 10, 1981Assignee: Burroughs Wellcome Co.Inventors: Janet L. Rideout, Thomas A. Krenitsky, Gertrude B. Elion