Glucose Patents (Class 436/95)
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Publication number: 20110081727Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.Type: ApplicationFiled: December 13, 2010Publication date: April 7, 2011Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, JR., Mark Alan Mortellaro, Aneta Modzelewska
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Publication number: 20110081726Abstract: Methods and devices for receiving a plurality of signals from a transcutaneously positioned analyte sensor, receiving a reference data, calibrating the analyte sensor based on the received reference data to generate calibrated sensor data, detecting a change in the level of the received plurality of signals from the analyte sensor exceeding a predetermined threshold level within a preset time period after calibrating the analyte sensor, and generating an output signal based on the detected change are provided. Systems and kits for performing the same are also provided.Type: ApplicationFiled: September 30, 2010Publication date: April 7, 2011Applicant: Abbott Diabetes Care Inc.Inventor: Glenn Howard Berman
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Publication number: 20110076776Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.Type: ApplicationFiled: May 20, 2009Publication date: March 31, 2011Inventors: Ray F. Stewart, Aaron Dickerman-Stewart
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Publication number: 20110076775Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of a surfactant-treated biological fluid sample are provided.Type: ApplicationFiled: May 20, 2009Publication date: March 31, 2011Inventors: Ray F. Stewart, Kathryn M. Morton, Aarpm Dickerman-Stewart, Nathan Mak
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Patent number: 7914752Abstract: The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.Type: GrantFiled: October 12, 2004Date of Patent: March 29, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Volker Unkrig, Christine Nortmeyer, Carina Horn, Michael Marquant, Mihail-Onoriu Lungu, Joachim Hoenes, Holger Kotzan, Joerg Dreibholz
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Patent number: 7910375Abstract: The invention relates to a test system for analyzing body fluids of the type comprising a test element tape carrying a plurality of test elements, a tape deflector for the test element tape for the selective application of body fluid, and a light source as well as a detector for optically analyzing test elements to which body fluid has been applied. The tape deflector has a rotatable optical element which acts as a deflection roller during transport of the test element tape. The optical element is positioned in the optical path between the light source and the detector.Type: GrantFiled: February 11, 2010Date of Patent: March 22, 2011Assignee: Roche Diagnostics Operations, Inc.Inventor: Wolfgang Petrich
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Patent number: 7897331Abstract: Thiazolyl tetrazolium salts with increased solubility in aqueous solutions have alkylammonium alkoxy substituents, preferably trimethyl ammonium propoxy groups substituents, on phenyl rings attached to the tetrazolium ring.Type: GrantFiled: June 16, 2010Date of Patent: March 1, 2011Assignee: Bayer HealthCare LLCInventors: James P. Albarella, Steven W. Felman, John J. Landi, Karen L. Marfurt
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Publication number: 20110009279Abstract: Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more biomarkers. The methods can differentiate between subjects with NASH and those with simple steatosis. Kits containing one or more agents for measuring the level of the biomarkers can be utilized to perform the described methods.Type: ApplicationFiled: September 22, 2010Publication date: January 13, 2011Inventors: Zobair M. Younossi, Mohammed H. Jarrar, Vikas Chandhoke, Ancha V. Baranova
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Patent number: 7867728Abstract: The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator.Type: GrantFiled: August 22, 2005Date of Patent: January 11, 2011Assignee: Bayer HealthCare LLCInventors: Karen L. Marfurt, Mary Ellen Warchal-Windham
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Publication number: 20100331653Abstract: The present disclosure provides in vitro analyte meters that include a meter portion that is moveable relative to at least one other meter portion. Embodiments include moveable meters that are integrated with in vivo analyte systems. Also provided are methods, systems and kits.Type: ApplicationFiled: June 30, 2009Publication date: December 30, 2010Applicant: Abbotte Diabetes Care Inc.Inventor: Gary Ashley Stafford
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Patent number: 7851225Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.Type: GrantFiled: November 30, 2007Date of Patent: December 14, 2010Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Mark Alan Mortellaro, Aneta Modzelewska
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Publication number: 20100311092Abstract: Disclosed is a method for measuring and determining whole body insulin release functionality, in which a plurality of physiologically acceptable differentially labeled carbohydrates is administered. A first administered carbohydrate label metabolizes faster than at least one of the other administered carbohydrate labels and recycling rates of at least two of the plurality of labeled carbohydrates are monitored. First and subsequent insulin release phases are detected. The first insulin release phase is detected by comparison of a recycling rate of the first administered carbohydrate with a recycling rate of the subsequent administered carbohydrate.Type: ApplicationFiled: December 1, 2008Publication date: December 9, 2010Inventor: Irwin J. Kurland
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Publication number: 20100297016Abstract: Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds. Also disclosed is a contact lens doped with the quaternary nitrogen heterocyclic boronic acid-containing compound, and a method of using the doped contact lens to measure the concentration of analyte in tears under physiological conditions.Type: ApplicationFiled: May 18, 2010Publication date: November 25, 2010Inventors: CHRIS D. GEDDES, RAMACHANDRAM BADUGU, JOSEPH R. LAKOWICZ
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Patent number: 7837938Abstract: A system and method for measuring substance concentrations is provided. The system has a test strip container for receiving a test strip(s). The container has a sealing device, a counter device that counts a number of opening processes of the sealing device, a data carrier that stores batch-specific data of the test strip(s), a data transmission device for wireless transmission of the data and of the number. An analysis module has a device for measuring substance concentrations by the test strip(s), and a data-receiving device for wireless reception of the data from the data transmission device and of the number. The method records the number and stores the number on the data carrier; sends data and the number by wireless transmission to the analysis module, and determines a substance concentration by the test strip(s). Also or instead, the counter device counts a time duration of the opening processes.Type: GrantFiled: December 20, 2005Date of Patent: November 23, 2010Assignee: Rōche Diagnostics Operations, Inc.Inventor: Albert Wohland
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Publication number: 20100286563Abstract: Analyte monitoring devices and methods therefore are provided. The devices integrate various functions of analyte monitoring, e.g., sample acquisition and testing.Type: ApplicationFiled: July 26, 2010Publication date: November 11, 2010Inventors: Philip Bryer, Irving Lee, Stephen J. Schoenberg, Lloyd M. Berken, Jean-Pierre Giraud
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Patent number: 7829341Abstract: The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.Type: GrantFiled: July 11, 2008Date of Patent: November 9, 2010Assignee: Glumetrics, Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Publication number: 20100279421Abstract: Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.Type: ApplicationFiled: February 26, 2010Publication date: November 4, 2010Applicant: Massachusetts Institute of TechnologyInventors: Michael S. Strano, Paul W. Barone
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Publication number: 20100279424Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: ApplicationFiled: June 3, 2010Publication date: November 4, 2010Applicant: GLUMETRICS INC.Inventor: JEFF T. SURI
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Patent number: 7824918Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: GrantFiled: August 6, 2008Date of Patent: November 2, 2010Assignee: Glumetrics, Inc.Inventor: Jeff T. Suri
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Publication number: 20100273661Abstract: A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine.Type: ApplicationFiled: June 11, 2008Publication date: October 28, 2010Applicants: SmithKline Beecham Corporation, BG Medicine IncInventors: Yang Qiu, Dilip Rajagopalan, Lei Zhu, Susan C Connor, Guanghui Hu, David Maclean, Doris Damian, Amir Handzel, Rajalakshmi Balasubramanian
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Publication number: 20100255460Abstract: A device for biochemical processing and analysis of a measured sample volume of a sample is described. The device is characterised in that it consists of a sealed vessel (1) and that it comprises at least one thin pierceable membrane (2) through which a capillary tube (3) containing said measured sample volume of a sample can pass into said sealed vessel (1). Said sealed vessel (1) further contains at least one biochemically reactive substance (4) and a liquid (6). A method, wherein the device according to the invention is used for analysis, is also described.Type: ApplicationFiled: October 24, 2008Publication date: October 7, 2010Inventors: Dario Kriz, Kirstin Kriz
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Publication number: 20100255506Abstract: Thiazolyl tetrazolium salts with increased solubility in aqueous solutions have alkylammonium alkoxy substituents, preferably trimethyl ammonium propoxy groups substituents, on phenyl rings attached to the tetrazolium ring.Type: ApplicationFiled: June 16, 2010Publication date: October 7, 2010Applicant: BAYER HEALTHCARE LLCInventors: James P. Albarella, Steven W. Felman, John J. Landi, Karen L. Marfurt
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Publication number: 20100255592Abstract: Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.Type: ApplicationFiled: March 14, 2008Publication date: October 7, 2010Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Michael J. Pugia, James A. Profitt
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Publication number: 20100240751Abstract: A perfluoroctanoic acid or a salt or an ester thereof; perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof; or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.Type: ApplicationFiled: January 19, 2010Publication date: September 23, 2010Inventors: Clifford Roy Elcombe, Charles Roland Wolf
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Publication number: 20100216175Abstract: Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels.Type: ApplicationFiled: August 15, 2007Publication date: August 26, 2010Inventors: Richard J. Melker, David G. Bjoraker, Donn Michael Dennis, Jon Dale Stewart, Christopher D. Batich, Matthew M. Booth, John Frederick Horn, Ronald Youngblood, Timothy E. Morey
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Patent number: 7781222Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: GrantFiled: August 7, 2008Date of Patent: August 24, 2010Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson
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Patent number: 7767846Abstract: A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.Type: GrantFiled: August 22, 2008Date of Patent: August 3, 2010Assignee: Glumetrics, Inc.Inventor: Jeff T Suri
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Patent number: 7763470Abstract: An analytical test element for determining an analyte in a body fluid comprises a detection area in which the analyte is detected and an application site at which the body fluid can be applied to the test element. The application site is spaced apart from the detection area, wherein at least some of the body fluid applied to the application site moves from the application site to the detection area. The test element also comprises a contamination area which at least partially adjoins the application site, wherein an adhesive substance is applied to at least part of the contamination area of the test element. The adhesive substance adheres to the contamination area of the test element and is able to interact with an excess amount of applied body fluid such that at least some of the body fluid adheres to the test element and thereby an excess amount of body fluid remains in the contamination area. An additional embodiment provides for test elements which, after use, can be stored in a storage container.Type: GrantFiled: September 22, 2007Date of Patent: July 27, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Branislav Babic, Martin Frank, Hans-Ludwig Griesheimer, Juergen Hoferer, Rudolf Pachl, Wilfried Schmid
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Patent number: 7763468Abstract: The present invention relates to a technique for analyzing a sample by utilizing a double integration circuit (11) for outputting a physical quantity related to the output from an analytical tool (2). In the present invention, the time interval from when the output from the analytical tool (2) is inputted into the double integration circuit (11) till when the physical quantity is started to be outputted from the double integration circuit (11) differs before and after the supply of the sample to the analytical tool (2) is confirmed.Type: GrantFiled: October 19, 2004Date of Patent: July 27, 2010Assignee: ARKRAY, Inc.Inventor: Takuji Kawai
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Publication number: 20100173346Abstract: Markers are provided for detecting coronary artery disease. Levels of these markers are indicative of a patient being at risk of having or developing coronary artery disease.Type: ApplicationFiled: March 24, 2008Publication date: July 8, 2010Applicant: BG MEDICINE, INC.Inventors: Aram Adourian, Doris Damian, Amir Handzel
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Publication number: 20100144048Abstract: The invention relates to a test system for analyzing body fluids of the type comprising a test element tape carrying a plurality of test elements, a tape deflector for the test element tape for the selective application of body fluid, and a light source as well as a detector for optically analyzing test elements to which body fluid has been applied. The tape deflector has a rotatable optical element which acts as a deflection roller during transport of the test element tape. The optical element is positioned in the optical path between the light source and the detector.Type: ApplicationFiled: February 11, 2010Publication date: June 10, 2010Inventor: Wolfgang Petrich
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Publication number: 20100136600Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.Type: ApplicationFiled: April 14, 2008Publication date: June 3, 2010Inventors: Carolyn Slupsky, Thomas Marrie
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Patent number: 7723113Abstract: A testing device for analyzing the glucose concentration of a sample of blood is adapted to remove a test sensor from a sensor package. The testing device comprises an inlet region and a puncturing member The inlet region receives a portion of the sensor package extending inward from an outer periphery of the test sensor package. The puncturing member is adapted to extend into the inlet region, puncture the sensor package, and to engage a mating feature of the test sensor. The puncturing member is adapted to hold the test sensor in the inlet region in a manner allowing the package to be removed and is adapted to hold the test sensor in the inlet region during testing a blood sample.Type: GrantFiled: July 30, 2002Date of Patent: May 25, 2010Assignee: Bayer HealthCare LLCInventor: Steven C. Charlton
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Patent number: 7723121Abstract: The invention concerns methods and reagent kits for the fluorimetric determination of analytes.Type: GrantFiled: February 4, 2004Date of Patent: May 25, 2010Inventors: Carina Horn, Joachim Hoenes, Jürgen Spinke
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Patent number: 7711493Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.Type: GrantFiled: November 9, 2005Date of Patent: May 4, 2010Assignee: Animas CorporationInventors: Miroslaw Bartkowiak, Wesley S. Harper, Eray Kulcu, Matthew J. Lesho, Janet A. Tamada
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Publication number: 20100105076Abstract: The present invention relates to a kit for analysing at least one target molecule comprising at least a first molecularly imprinted polymer and a second molecularly imprinted polymer which are chemically identical or different, capable of interacting with the target molecule(s), and at least one marker, wherein said marker is either a competitive marker or marker capable of (i) of interacting with all or part of the recognition sites for the target molecule(s) of the second molecularly imprinted polymer and (ii) of being displaced from said recognition site(s) by the target molecule(s) when said molecularly imprinted polymer is placed in the presence of said target molecule(s), or an intrinsic marker or a constitutive unit of the second molecularly imprinted polymer, capable (i?) of interacting with all or part of the target molecule(s) when the latter interact(s) with all or part of its recognition sites for said target molecule(s) and (ii?) of consequently emitting a detectable signal.Type: ApplicationFiled: March 20, 2008Publication date: April 29, 2010Applicant: PolyintellInventors: Celine Perollier, Kaynoush Naraghi, Sami Bayoudh
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Patent number: 7704747Abstract: Disclosed herein is a dual blood glucose meter. The dual blood glucose meter includes a meter body, a measurement strip, a variety of electronic parts and upper and lower strip receiving ports. The meter body is provided with a liquid crystal display panel on the front thereof to display measured numerical values and various pieces of pictorial information. The measurement strip is brought into contact with blood at a blood collection spot so as to measure blood glucose of the blood. The electronic parts are used to measure the blood glucose of the blood. The upper and lower strip receiving ports are formed at upper and lower ends of the meter body to receive the measurement strip, and are each electrically connected to the electric parts.Type: GrantFiled: April 15, 2004Date of Patent: April 27, 2010Assignee: i-SENS, Inc.Inventors: Moon Hwan Kim, Keun Ki Kim, Gang Cui, Hakhyun Nam, Geun-Sig Cha
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Patent number: 7695677Abstract: Glucose analysis instrument for diabetics, comprising a measuring device for determining glucose concentration values, a displaying device for displaying glucose concentration values, a signaling device for generating a reminder signal, and a control and evaluation device that comprises a processor and a data memory and is used to determine reminder times at which the signaling device is actuated. Event data are stored in the data memory, the event data containing information on events occurring in the life of a user of the glucose analysis instrument and on the time of occurrence of such events. The reminder times are determined by means of a reminder time determination algorithm taking into consideration event data from at least one previous day.Type: GrantFiled: June 19, 2006Date of Patent: April 13, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Karl Werner, Peter Stephan, Robert Lorenz
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Publication number: 20100068820Abstract: An adhesive is provided containing at least one synthetic polymer with receptor sites that enable the selective capture or release of a target molecule. A polymer is synthesized by polymerizing and cross-linking a functional monomer or functional copolymers in the presence of a target or template molecule allowing for reversible interactions between the polymer and the target molecule. The target molecule may be extracted from the polymer creating receptor sites complimentary to the target molecule. Alternatively, the target molecule may remain in the polymer network and be controllably released. The molecularly imprinted polymer is formulated into an adhesive. The adhesive can be used as a component in an in-vitro diagnostic device to release template molecules or to capture target molecules in vacated receptor sites in the synthetic polymer.Type: ApplicationFiled: June 22, 2006Publication date: March 18, 2010Applicant: ADHESIVES RESEARCH, INC.Inventors: William Meathrel, Benjamin Wagner
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Publication number: 20100041083Abstract: A meter adapted for evaluating, saving and simultaneously displaying the number of analyte concentration readings that are greater than a first predetermined analyte concentration level, the number of analyte concentration readings that are less than a second predetermined analyte concentration level and the total number of analyte concentration readings over a predetermined time interval.Type: ApplicationFiled: March 12, 2007Publication date: February 18, 2010Applicant: BAYER HEALTHCARE LLCInventors: Barry D. Power, Jeffrey Culver
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MICROWAVE TRIGGER METAL-ENHANCED CHEMILUMINESCENCE (MT MEC) AND SPATIAL AND TEMPORAL CONTROL OF SAME
Publication number: 20100003695Abstract: The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using metallic geometric structures for spatially and temporally controlling the biological and chemical reactions.Type: ApplicationFiled: February 25, 2008Publication date: January 7, 2010Applicant: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTEInventors: Chris D. Geddes, Michael Previte -
Patent number: 7641777Abstract: A connector for establishing electrical connection between a testing device and a test strip with a biological fluid thereon includes a contact pad on the test strip, and one or more contact wires in the testing device. When the strip is inserted into the testing device, the end of the strip engages with a bight in the contact wire, pushing the contact wire in a direction normal to the direction of insertion. The movement of the contact wire forces a second portion of the wire against a part of the housing, thereby deforming the wire and moving another portion of the wire toward the contact pad. Some embodiments of the invention include 4, 6, 8, 15, or more contacts, which may be situated so as to receive the end of the test strip substantially simultaneously, or may be staggered in 2, 3, or more rows to spread out the resistance to movement presented.Type: GrantFiled: September 7, 2004Date of Patent: January 5, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Abner D. Joseph, Jack Schlanser
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Patent number: 7635595Abstract: The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2?1), arsenious acid, H3 AsO3 (or arsenite ion, H2AsO3?1), telluric acid, H6TeO6 (or tellurate ion, H5 TeO6?1) or germanic acid, Ge(OH)6 (or germanate ion, GeO(OH)3?1) are described. Method of using said probes are also provided.Type: GrantFiled: March 10, 2005Date of Patent: December 22, 2009Inventors: Joseph R. Lakowicz, Nicolas Dicesare
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Patent number: 7629175Abstract: The invention concerns test elements and methods for the optical detection of an analyte in a sample. The test element includes a support having at least one transparent portion, and a one-layer film positioned on the support. The film has a thickness when dry of less than about 10 ?m. The method includes contacting the sample with the test element and determining the analyte concentration in the sample.Type: GrantFiled: February 18, 2005Date of Patent: December 8, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Wolfgang-Reinhold Knappe, Franz Wittmann, Dan Mosoiu, Carina Horn, Joachim Hoenes
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Patent number: 7629172Abstract: The invention is directed to entrapped mutated binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrixes, and their use as analyte biosensors both in vitro and in vivo.Type: GrantFiled: September 27, 2004Date of Patent: December 8, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Christopher J. Knors, J. Bruce Pitner
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Patent number: 7629174Abstract: An analyte detector is disclosed. The analyte detector includes a substrate having a surface, a self-assembled monolayer comprising a plurality of molecules bonded to the surface, the molecules having a structure (I) defined herein, and a liquid crystal layer having a plurality of liquid crystal molecules aligned on a top surface of the self-assembled monolayer. The liquid crystal molecule includes a diol moiety that interacts with the molecule having a structure (I). Methods of detecting an analyte are also disclosed.Type: GrantFiled: August 26, 2005Date of Patent: December 8, 2009Assignee: Honeywell International Inc.Inventor: Yuandong Gu
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Patent number: 7619053Abstract: A non-reactive monomer mixture has a monomer component dispersed in a melted diaryl carbonate. The monomer component has one or more monomer compounds having a melting point below the melting point of the diaryl carbonate. Furthermore, the monomer component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The monomer compounds of the monomer component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the melting temperature of the lowest melting monomer compound and the melting temperature of the diaryl carbonate.Type: GrantFiled: March 26, 2008Date of Patent: November 17, 2009Assignee: Sabic Innovative Plastics IP B.V.Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Martin Herke Oyevaar, Yohana Perez de Diego, Laurus van der Wekke, Dennis James Patrick Maria Willemse
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Patent number: 7615605Abstract: A non-reactive monomer mixture contains a monomer component and a diaryl carbonate dispersed in the mixture. The monomer component includes one or more monomer compounds having a melting point below the melting point of the diaryl carbonate. The monomer component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The monomer compounds of the monomer component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the melting temperature of the lowest melting monomer compound and less than 5° C. above the melting point of the diaryl carbonate.Type: GrantFiled: September 19, 2008Date of Patent: November 10, 2009Assignee: Sabic Innovative Plastics IP B.V.Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Yohana Perez de Diego, Dennis James Patrick Maria Willemse
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Patent number: 7601794Abstract: A non-reactive monomer mixture is formed from a dihydroxy component having one or more dihydroxy compounds dissolved in a melted diaryl carbonate. The dihydroxy component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The dihydroxy compounds of the dihydroxy component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the saturation point of the monomer mixture and the highest melting temperature of the individual dihydroxy compounds. The non-reactive monomer mixture can be stored and transported and then polymerized to form polycarbonate upon addition of a catalyst.Type: GrantFiled: September 28, 2007Date of Patent: October 13, 2009Assignee: Sabic Innovative Plastics IP B.V.Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Yohana Perez de Diego, Martin Herke Oyevaar, Laurus van der Wekke, Dennis Willemse
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Publication number: 20090247984Abstract: Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.Type: ApplicationFiled: October 24, 2008Publication date: October 1, 2009Applicant: Masimo Laboratories, Inc.Inventors: Marcelo Lamego, Sean Merritt, Grace Young